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Aliases for HMGCR Gene

Aliases for HMGCR Gene

  • 3-Hydroxy-3-Methylglutaryl-CoA Reductase 2 3 5
  • 3-Hydroxy-3-Methylglutaryl CoA Reductase (NADPH) 2 3
  • 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase 2 3
  • Hydroxymethylglutaryl-CoA Reductase 2 3
  • HMG-CoA Reductase 3 4
  • EC 1.1.1.34 4 61
  • EC 1.1.1 61
  • LDLCQ3 3

External Ids for HMGCR Gene

Previous GeneCards Identifiers for HMGCR Gene

  • GC05P073440
  • GC05P074869
  • GC05P074671
  • GC05P074717
  • GC05P074668
  • GC05P069838
  • GC05P074635

Summaries for HMGCR Gene

Entrez Gene Summary for HMGCR Gene

  • HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for HMGCR Gene

HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) is a Protein Coding gene. Diseases associated with HMGCR include Cerebrotendinous Xanthomatosis and Mevalonic Aciduria. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and Terpenoid backbone biosynthesis. GO annotations related to this gene include protein homodimerization activity and NADP binding.

UniProtKB/Swiss-Prot for HMGCR Gene

  • Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Tocris Summary for HMGCR Gene

  • 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) catalyzes the rate limiting step in cholesterol biosynthesis - conversion of 3-hydroxy-3-methyl-glutaryl-CoA to mevalonic acid. HMG-CoA reductase is a transmembrane enzyme, bound to endoplasmic reticulum.

Gene Wiki entry for HMGCR Gene

PharmGKB "VIP" Summary for HMGCR Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for HMGCR Gene

Genomics for HMGCR Gene

Regulatory Elements for HMGCR Gene

Enhancers for HMGCR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around HMGCR on UCSC Golden Path with GeneCards custom track

Promoters for HMGCR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for HMGCR Gene

Chromosome:
5
Start:
75,336,329 bp from pter
End:
75,362,104 bp from pter
Size:
25,776 bases
Orientation:
Plus strand

Genomic View for HMGCR Gene

Genes around HMGCR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMGCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMGCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGCR Gene

Proteins for HMGCR Gene

  • Protein details for HMGCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04035-HMDH_HUMAN
    Recommended name:
    3-hydroxy-3-methylglutaryl-coenzyme A reductase
    Protein Accession:
    P04035
    Secondary Accessions:
    • B7Z3Y9
    • Q8N190

    Protein attributes for HMGCR Gene

    Size:
    888 amino acids
    Molecular mass:
    97476 Da
    Quaternary structure:
    • Homodimer. Interacts (via its SSD) with INSIG1; the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Interacts with UBIAD1.
    SequenceCaution:
    • Sequence=BAH12375.1; Type=Frameshift; Positions=122; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HMGCR Gene

    Alternative splice isoforms for HMGCR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HMGCR Gene

Post-translational modifications for HMGCR Gene

  • N-glycosylated. Deglycosylated by NGLY1 on release from the endoplasmic reticulum (ER) in a sterol-mediated manner.
  • Undergoes sterol-mediated ubiquitination and ER-association degradation (ERAD). Accumulation of sterols in the endoplasmic reticulum (ER) membrane, triggers binding of the reductase to the ER membrane protein INSIG1. This INSIG1 binding leads to the recruitment of the ubiquitin ligase, AMFR/gp78, initiating ubiquitination of the reductase. The ubiquitinated reductase is then extracted from the ER membrane and delivered to cytosolic 26S proteosomes by a mechanism probably mediated by the ATPase Valosin-containing protein VCP/p97. Lys-248 is the main site of ubiquitination. Ubiquitination is enhanced by the presence of a geranylgeranylated protein.
  • Ubiquitination at Lys 89, Lys 248, Lys 288, Lys 299, Lys 381, Lys 401, Lys 460, Lys 474, Lys 480, Lys 619, Lys 633, Lys 662, Lys 704, Lys 715, Lys 864, and Lys 873
  • Glycosylation at Asn 281, Asn 296, Asn 419, Asn 518, and Asn 870
  • Modification sites at PhosphoSitePlus

Domains & Families for HMGCR Gene

Gene Families for HMGCR Gene

Suggested Antigen Peptide Sequences for HMGCR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04035

UniProtKB/Swiss-Prot:

HMDH_HUMAN :
  • Contains 1 SSD (sterol-sensing) domain.
  • Belongs to the HMG-CoA reductase family.
Domain:
  • Contains 1 SSD (sterol-sensing) domain.
Family:
  • Belongs to the HMG-CoA reductase family.
genes like me logo Genes that share domains with HMGCR: view

Function for HMGCR Gene

Molecular function for HMGCR Gene

GENATLAS Biochemistry:
3-hydroxy-3-methylglutaryl-CoA reductase,catalyzing a rate-limiting step in cholesterol biosynthesis
UniProtKB/Swiss-Prot CatalyticActivity:
(R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.
UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by a negative feedback mechanism through sterols and non-sterol metabolites derived from mevalonate. Inhibited by statins, a class of hypolipidemic agents used as pharmaceuticals to lower cholesterol levels in individuals at risk from cardiovascular disease due to hypercholesterolemia. Inhibition of HMGCR in the liver stimulates the LDL-receptors, which results in an increased clearance of LDL from the bloodstream and a decrease in blood cholesterol levels. The first results can be seen after one week of statin use and the effect is maximal after four to six weeks.
UniProtKB/Swiss-Prot Function:
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Enzyme Numbers (IUBMB) for HMGCR Gene

Gene Ontology (GO) - Molecular Function for HMGCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity IBA --
GO:0005515 protein binding IPI 23169578
GO:0042282 hydroxymethylglutaryl-CoA reductase activity IDA 2991281
GO:0042803 protein homodimerization activity IEA --
GO:0050662 coenzyme binding IDA 10698924
genes like me logo Genes that share ontologies with HMGCR: view
genes like me logo Genes that share phenotypes with HMGCR: view

Animal Models for HMGCR Gene

MGI Knock Outs for HMGCR:

Animal Model Products

  • Taconic Biosciences Mouse Models for HMGCR

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HMGCR

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HMGCR Gene

Localization for HMGCR Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGCR Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMGCR Gene COMPARTMENTS Subcellular localization image for HMGCR gene
Compartment Confidence
endoplasmic reticulum 5
peroxisome 5
plasma membrane 4
extracellular 3
cytosol 2
mitochondrion 2
nucleus 2
cytoskeleton 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HMGCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005778 peroxisomal membrane IDA 17180682
GO:0005783 endoplasmic reticulum IDA 17180682
GO:0005789 endoplasmic reticulum membrane TAS 2991281
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
genes like me logo Genes that share ontologies with HMGCR: view

Pathways & Interactions for HMGCR Gene

genes like me logo Genes that share pathways with HMGCR: view

UniProtKB/Swiss-Prot P04035-HMDH_HUMAN

  • Pathway: Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.

Gene Ontology (GO) - Biological Process for HMGCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006695 cholesterol biosynthetic process TAS --
GO:0006743 ubiquinone metabolic process IEA --
GO:0007568 aging IEA --
GO:0007584 response to nutrient IEA --
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with HMGCR: view

No data available for SIGNOR curated interactions for HMGCR Gene

Drugs & Compounds for HMGCR Gene

(127) Drugs for HMGCR Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lovastatin Approved, Investigational Pharma Competitive, Inhibitor, inhibitor, Target HMG-CoA reductase inhibitor, Potent HMG-CoA reductase inhibitor 60
Pravastatin Approved Pharma Competitive, Inhibitor, inhibitor, Target 147
Simvastatin Approved Pharma Competitive, Inhibitor, inhibitor, Target HMG-CoA reductase inhibitor 503
Fluvastatin Approved Pharma Competitive, Inhibitor, inhibitor, Target HMGCR inhibitor 58
atorvastatin Approved Pharma Competitive, Inhibitor, inhibitor, Target 0

(61) Additional Compounds for HMGCR Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-hydroxy-3-methylglutaryl-coa
  • (S)-3-hydroxy-3-methylglutaryl-CoA
  • (S)-3-hydroxy-3-methylglutaryl-Coenzyme A
  • 3-Hydroxy-3-methyl-Glutaryl-CoA
  • 3-Hydroxy-3-methyl-Glutaryl-Coenzyme A
  • 3-Hydroxy-3-methylglutaryl-CoA
1553-55-5
6-Hydroxyfluvastatin
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
Mevalonic acid
  • (3RS)-Mevalonate
  • (3RS)-Mevalonic acid
  • 2,4-Dideoxy-3-C-methylpentonate
  • 2,4-Dideoxy-3-C-methylpentonic acid
  • 3,5-Dihydroxy-3-methyl-Valerate
150-97-0
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8

(5) Tocris Compounds for HMGCR Gene

Compound Action Cas Number
Fluvastatin sodium Potent HMG-CoA reductase inhibitor 93957-55-2
Lovastatin Potent HMG-CoA reductase inhibitor 75330-75-5
Mevastatin HMG-CoA reductase inhibitor 73573-88-3
Pitavastatin calcium HMG-CoA reductase inhibitor 147526-32-7
Simvastatin HMG-CoA reductase inhibitor 79902-63-9

(14) ApexBio Compounds for HMGCR Gene

Compound Action Cas Number
Atorvastatin Calcium HMG-CoA reductase inhibitor 134523-03-8
Clinofibrate HMGCR inhibitor 30299-08-2
Fluvastatin HMGCR inhibitor 93957-54-1
Fluvastatin (Lescol) 93957-55-2
Fluvastatin Sodium HMG-CoA reductase inhibitor 93957-55-2
Lovastatin HMG-CoA reductase inhibitor 75330-75-5
Mevastatin HMG-CoA reductase inhibitor 73573-88-3
Pitavastatin HMG-CoA reductase inhibitor 147511-69-1
Pitavastatin Calcium Enzyme HMGCR inhibitor 147526-32-7
Pravastatin 81093-37-0
Pravastatin sodium HMG-CoA reductase inhibitor,highly selective and competitive 81131-70-6
Rosuvastatin 287714-41-4
Rosuvastatin Calcium 147098-20-2
Simvastatin (Zocor) HMGCR (HMG-CoA reductase) inhibitor 79902-63-9
genes like me logo Genes that share compounds with HMGCR: view

Drug Products

Transcripts for HMGCR Gene

Unigene Clusters for HMGCR Gene

3-hydroxy-3-methylglutaryl-CoA reductase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HMGCR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HMGCR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b
SP1: - - - -
SP2: - - -
SP3:
SP4:
SP5:

Relevant External Links for HMGCR Gene

GeneLoc Exon Structure for
HMGCR
ECgene alternative splicing isoforms for
HMGCR

Expression for HMGCR Gene

mRNA expression in normal human tissues for HMGCR Gene

Protein differential expression in normal tissues from HIPED for HMGCR Gene

This gene is overexpressed in Fetal testis (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HMGCR Gene



NURSA nuclear receptor signaling pathways regulating expression of HMGCR Gene:

HMGCR

SOURCE GeneReport for Unigene cluster for HMGCR Gene:

Hs.628096
genes like me logo Genes that share expression patterns with HMGCR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for HMGCR Gene

Orthologs for HMGCR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HMGCR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HMGCR 34
  • 90.92 (n)
  • 95.38 (a)
HMGCR 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HMGCR 34
  • 92.23 (n)
  • 95.72 (a)
HMGCR 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmgcr 34
  • 86.55 (n)
  • 93.57 (a)
Hmgcr 16
Hmgcr 35
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HMGCR 34
  • 99.7 (n)
  • 99.77 (a)
HMGCR 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hmgcr 34
  • 86.13 (n)
  • 92.9 (a)
oppossum
(Monodelphis domestica)
Mammalia HMGCR 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HMGCR 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves HMGCR 34
  • 79.09 (n)
  • 86.29 (a)
HMGCR 35
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HMGCR 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hmgcr 34
  • 74.99 (n)
  • 82.18 (a)
Str.16151 34
African clawed frog
(Xenopus laevis)
Amphibia LOC397750 34
zebrafish
(Danio rerio)
Actinopterygii hmgcra 34
  • 70.29 (n)
  • 78.34 (a)
hmgcra 35
  • 78 (a)
OneToMany
hmgcrb 35
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Hmgcr 36
  • 44 (a)
Hmgcr 34
  • 53.44 (n)
  • 51.14 (a)
Hmgcr 35
  • 45 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002288 34
  • 51.83 (n)
  • 50.53 (a)
worm
(Caenorhabditis elegans)
Secernentea F08F8.2 36
  • 46 (a)
hmgr-1 34
  • 54 (n)
  • 48.16 (a)
hmgr-1 35
  • 42 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER152W 34
  • 46.31 (n)
  • 42.4 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04642g 34
  • 48.99 (n)
  • 42.97 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMG2 34
  • 57.36 (n)
  • 59.15 (a)
HMG1 35
  • 32 (a)
OneToMany
HMG2 35
  • 32 (a)
OneToMany
HMG2 37
thale cress
(Arabidopsis thaliana)
eudicotyledons HMG1 34
  • 59.33 (n)
  • 57.18 (a)
soybean
(Glycine max)
eudicotyledons Gma.4589 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10817 34
barley
(Hordeum vulgare)
Liliopsida Hv.5593 34
rice
(Oryza sativa)
Liliopsida Os.164 34
Os08g0512700 34
  • 57.4 (n)
  • 57.8 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.1571 34
corn
(Zea mays)
Liliopsida Zm.2360 34
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2237 34
bread mold
(Neurospora crassa)
Ascomycetes NCU00712 34
  • 58.15 (n)
  • 60.72 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hmg1 34
  • 54.91 (n)
  • 55.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToOne
Species where no ortholog for HMGCR was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for HMGCR Gene

ENSEMBL:
Gene Tree for HMGCR (if available)
TreeFam:
Gene Tree for HMGCR (if available)

Paralogs for HMGCR Gene

No data available for Paralogs for HMGCR Gene

Variants for HMGCR Gene

Sequence variations from dbSNP and Humsavar for HMGCR Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs5908 - 75,356,374(+) CAAGT(A/G)TAGCT reference, missense
rs10045497 -- 75,340,659(+) GGTCC(A/C)AAGCA intron-variant
rs10053643 -- 75,353,673(+) AGAGA(C/T)GGGGT intron-variant
rs4629571 -- 75,362,479(+) CTGTG(A/G)GTCAG downstream-variant-500B
rs11957984 -- 75,343,350(+) ctact(C/G)ggaag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMGCR Gene

Variant ID Type Subtype PubMed ID
esv3304309 CNV mobile element insertion 20981092
esv3575856 CNV gain 25503493

Variation tolerance for HMGCR Gene

Residual Variation Intolerance Score: 6.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 26.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HMGCR Gene

Human Gene Mutation Database (HGMD)
HMGCR
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HMGCR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGCR Gene

Disorders for HMGCR Gene

MalaCards: The human disease database

(26) MalaCards diseases for HMGCR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cerebrotendinous xanthomatosis
  • cholestanol storage disease
mevalonic aciduria
  • mevalonate kinase deficiency
sitosterolemia
  • beta-sitosterolemia
lichen planus pemphigoides
  • lp pemphigoides
atherosclerosis
  • arteriosclerosis
- elite association - COSMIC cancer census association via MalaCards
Search HMGCR in MalaCards View complete list of genes associated with diseases

Relevant External Links for HMGCR

Genetic Association Database (GAD)
HMGCR
Human Genome Epidemiology (HuGE) Navigator
HMGCR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HMGCR
genes like me logo Genes that share disorders with HMGCR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HMGCR Gene

Publications for HMGCR Gene

  1. Variants in the HMG-CoA reductase (HMGCR) gene influence component phenotypes in polycystic ovary syndrome. (PMID: 19327767) Xu N. … Goodarzi M.O. (Fertil. Steril. 2010) 3 22 46 65
  2. Gene-gene and gene - clinical factors interaction in acute myocardial infarction: a new detailed risk chart. (PMID: 20388088) Licastro F. … Ferrari R. (Curr. Pharm. Des. 2010) 3 22 46 65
  3. Interaction between HMGCR and ABCA1 cholesterol-related genes modulates Alzheimer's disease risk. (PMID: 19446537) RodrA-guez-RodrA-guez E. … Combarros O. (Brain Res. 2009) 3 22 46 65
  4. (TTA)n polymorphism in 3-hydroxy-3-methylglutaryl-coenzyme A and response to atorvastatin in coronary artery disease patients. (PMID: 19067673) Noriega V. … Prieto J.C. (Basic Clin. Pharmacol. Toxicol. 2009) 3 22 46 65
  5. Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13. (PMID: 18802019) Burkhardt R. … Breslow J.L. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 22 46 65

Products for HMGCR Gene

Sources for HMGCR Gene

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