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Aliases for HMGCR Gene

Aliases for HMGCR Gene

  • 3-Hydroxy-3-Methylglutaryl-CoA Reductase 2 3
  • 3-Hydroxy-3-Methylglutaryl CoA Reductase (NADPH) 2 3
  • 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase 2 3
  • Hydroxymethylglutaryl-CoA Reductase 2 3
  • HMG-CoA Reductase 3 4
  • EC 1.1.1.34 4 63
  • HMG CoA Reductase 6
  • EC 1.1.1 63
  • LDLCQ3 3

External Ids for HMGCR Gene

Previous GeneCards Identifiers for HMGCR Gene

  • GC05P073440
  • GC05P074869
  • GC05P074671
  • GC05P074717
  • GC05P074668
  • GC05P069838
  • GC05P074635

Summaries for HMGCR Gene

Entrez Gene Summary for HMGCR Gene

  • HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for HMGCR Gene

HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) is a Protein Coding gene. Diseases associated with HMGCR include smith-lemli-opitz syndrome and xanthomatosis. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Metabolism. GO annotations related to this gene include protein homodimerization activity and NADPH binding.

UniProtKB/Swiss-Prot for HMGCR Gene

  • Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins

Tocris Summary for HMGCR Gene

  • 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) catalyzes the rate limiting step in cholesterol biosynthesis - the conversion of 3-hydroxy-3-methyl-glutaryl-CoA into mevalonic acid. This transmembrane enzyme is bound to the endoplasmic reticulum and is ubiquitously expressed. When cholesterol levels falls, HMG-CoA reductase is transcriptionally upregulated by sterol regulatory element binding protein (SREBP), which binds to the sterol regulatory element (SRE) in the 5' region of the HMG-CoA gene. When cholesterol levels are elevated, short-term regulation of HMG-CoA is mediated by Ser872 phosphorylation by AMP-activated protein kinase and long-term regulation is mediated by the increased sensitivity of this enzyme to proteolytic breakdown. HMG-CoA reductase is the pharmalogical target for statins and the human gene encoding this enzyme is localized to 5q13.3-q14.

Gene Wiki entry for HMGCR Gene

PharmGKB "VIP" Summary for HMGCR Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for HMGCR Gene

Genomics for HMGCR Gene

Regulatory Elements for HMGCR Gene

Genomic Location for HMGCR Gene

Start:
75,336,329 bp from pter
End:
75,362,104 bp from pter
Size:
25,776 bases
Orientation:
Plus strand

Genomic View for HMGCR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMGCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGCR Gene

Proteins for HMGCR Gene

  • Protein details for HMGCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04035-HMDH_HUMAN
    Recommended name:
    3-hydroxy-3-methylglutaryl-coenzyme A reductase
    Protein Accession:
    P04035
    Secondary Accessions:
    • B7Z3Y9
    • Q8N190

    Protein attributes for HMGCR Gene

    Size:
    888 amino acids
    Molecular mass:
    97476 Da
    Quaternary structure:
    • Homodimer. Interacts (via its SSD) with INSIG1; the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Interacts with UBIAD1.
    SequenceCaution:
    • Sequence=BAH12375.1; Type=Frameshift; Positions=122; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HMGCR Gene

    Alternative splice isoforms for HMGCR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HMGCR Gene

Proteomics data for HMGCR Gene at MOPED

Post-translational modifications for HMGCR Gene

  • N-glycosylated. Deglycosylated by NGLY1 on release from the endoplasmic reticulum (ER) in a sterol-mediated manner.
  • Undergoes sterol-mediated ubiquitination and ER-association degradation (ERAD). Accumulation of sterols in the endoplasmic reticulum (ER) membrane, triggers binding of the reductase to the ER membrane protein INSIG1. This INSIG1 binding leads to the recruitment of the ubiquitin ligase, AMFR/gp78, initiating ubiquitination of the reductase. The ubiquitinated reductase is then extracted from the ER membrane and delivered to cytosolic 26S proteosomes by a mechanism probably mediated by the ATPase Valosin-containing protein VCP/p97. Lys-248 is the main site of ubiquitination. Ubiquitination is enhanced by the presence of a geranylgeranylated protein.
  • Ubiquitination at Lys89, Lys248, Lys288, Lys299, Lys381, Lys396, Lys401, Lys460, Lys474, Lys480, Lys502, Lys619, Lys633, Lys662, Lys704, Lys715, Lys864, and Lys873
  • Glycosylation at Asn281, Asn296, Asn419, Asn518, and Asn870
  • Modification sites at PhosphoSitePlus

Domains for HMGCR Gene

Suggested Antigen Peptide Sequences for HMGCR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04035

UniProtKB/Swiss-Prot:

HMDH_HUMAN :
  • P04035
Domain:
  • Contains 1 SSD (sterol-sensing) domain.
Family:
  • Belongs to the HMG-CoA reductase family.
genes like me logo Genes that share domains with HMGCR: view

Function for HMGCR Gene

Molecular function for HMGCR Gene

GENATLAS Biochemistry: 3-hydroxy-3-methylglutaryl-CoA reductase,catalyzing a rate-limiting step in cholesterol biosynthesis
UniProtKB/Swiss-Prot CatalyticActivity: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.
UniProtKB/Swiss-Prot EnzymeRegulation: Regulated by a negative feedback mechanism through sterols and non-sterol metabolites derived from mevalonate. Inhibited by statins, a class of hypolipidemic agents used as pharmaceuticals to lower cholesterol levels in individuals at risk from cardiovascular disease due to hypercholesterolemia. Inhibition of HMGCR in the liver stimulates the LDL-receptors, which results in an increased clearance of LDL from the bloodstream and a decrease in blood cholesterol levels. The first results can be seen after one week of statin use and the effect is maximal after four to six weeks.
UniProtKB/Swiss-Prot Function: Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins

Enzyme Numbers (IUBMB) for HMGCR Gene

Gene Ontology (GO) - Molecular Function for HMGCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity IBA --
GO:0005515 protein binding IPI 23169578
GO:0008158 hedgehog receptor activity --
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor --
GO:0042282 hydroxymethylglutaryl-CoA reductase activity IDA 2991281
genes like me logo Genes that share ontologies with HMGCR: view

Phenotypes for HMGCR Gene

MGI mutant phenotypes for HMGCR:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with HMGCR: view

Animal Models for HMGCR Gene

MGI Knock Outs for HMGCR:

No data available for Transcription Factor Targeting and HOMER Transcription for HMGCR Gene

Localization for HMGCR Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGCR Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMGCR Gene COMPARTMENTS Subcellular localization image for HMGCR gene
Compartment Confidence
endoplasmic reticulum 5
peroxisome 5
extracellular 3
plasma membrane 3
cytosol 2
mitochondrion 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for HMGCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005778 peroxisomal membrane IDA 17180682
GO:0005783 endoplasmic reticulum IDA 17180682
GO:0005789 endoplasmic reticulum membrane TAS 2991281
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HMGCR: view

Pathways for HMGCR Gene

genes like me logo Genes that share pathways with HMGCR: view

UniProtKB/Swiss-Prot P04035-HMDH_HUMAN

  • Pathway: Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3

Gene Ontology (GO) - Biological Process for HMGCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006695 cholesterol biosynthetic process TAS --
GO:0006743 ubiquinone metabolic process IEA --
GO:0007568 aging IEA --
GO:0007584 response to nutrient IEA --
GO:0008284 positive regulation of cell proliferation --
genes like me logo Genes that share ontologies with HMGCR: view

Compounds for HMGCR Gene

(5) Tocris Compounds for HMGCR Gene

Compound Action Cas Number
Atorvastatin hemicalcium salt HMG-CoA reductase inhibitor [134523-03-8]
Fluvastatin sodium HMG-CoA reductase inhibitor [93957-55-2]
Lovastatin HMG-CoA reductase inhibitor [75330-75-5]
Pitavastatin calcium HMG-CoA reductase inhibitor [147526-32-7]
Simvastatin HMG-CoA reductase inhibitor [79902-63-9]

(8) HMDB Compounds for HMGCR Gene

Compound Synonyms Cas Number PubMed IDs
3-Hydroxy-3-methylglutaryl-CoA
  • (S)-3-hydroxy-3-methylglutaryl-CoA
1553-55-5
Atorvastatin
  • Atorvastatin acid
134523-00-5
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
85-61-0
Mevalonic acid
  • (3RS)-Mevalonate
150-97-0
NADP
  • Adenine-nicotinamide dinucleotide phosphate
53-59-8

(38) IUPHAR Ligand for HMGCR Gene

Ligand Type Action Affinity Pubmed IDs
(3R,5S,6E)-7-[4-(4-fluorophenyl)-1-phenyl-2-(propan-2-yl)-1H-pyrrol-3-yl]-3,5-dihydroxyhept-6-enoate Inhibitor Inhibition 11
(3R,5R)-7-[1-cyclohexyl-4-(4-fluorophenyl)-2-(propan-2-yl)-1H-pyrrol-3-yl]-3,5-dihydroxyheptanoate Inhibitor Inhibition 11
(3R,5R)-7-[4-(4-fluorophenyl)-1-phenyl-2-(propan-2-yl)-1H-pyrrol-3-yl]-3,5-dihydroxyheptanoate Inhibitor Inhibition 11
(3R,5S,6E)-7-[4-(4-fluorophenyl)-1,2-bis(propan-2-yl)-1H-pyrrol-3-yl]-3,5-dihydroxyhept-6-enoate Inhibitor Inhibition 10.3
(3R,5S,6E)-7-[1-cyclohexyl-4-(4-fluorophenyl)-2-(propan-2-yl)-1H-pyrrol-3-yl]-3,5-dihydroxyhept-6-enoate Inhibitor Inhibition 10
(3R,5R)-7-(5-{[(4-cyanophenyl)methyl]carbamoyl}-3-(4-fluorophenyl)-4-phenyl-1-(propan-2-yl)-1H-pyrrol-2-yl)-3,5-dihydroxyheptanoate Inhibitor Inhibition 9.7
(3R,5R)-7-[4-(4-fluorophenyl)-2-methyl-1-(propan-2-yl)-1H-pyrrol-3-yl]-3,5-dihydroxyheptanoate Inhibitor Inhibition 9.57
(3R,5R)-7-[3-(4-fluorophenyl)-8-oxo-7-phenyl-1-(propan-2-yl)-1H,4H,5H,6H,7H,8H-pyrrolo[2,3-c]azepin-2-yl]-3,5-dihydroxyheptanoate Inhibitor Inhibition 9.52
(3R)-6-[2-(4-fluorophenyl)-4-[(4-fluorophenyl)sulfanyl]-6-(propan-2-yl)phenoxy]-3,5-dihydroxyhexanoate Inhibitor Inhibition 9.3
(3R,5R)-7-[4-(4-fluorophenyl)-2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl]-3,5-dihydroxyheptanoate Inhibitor Inhibition 9.24
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-methyl-1-phenyl-1H-pyrrol-3-yl]-3,5-dihydroxyhept-6-enoate Inhibitor Inhibition 9.08
(4R)-6-[2-(4-fluorophenyl)-4,6-bis(propan-2-yl)phenoxymethyl]-4-hydroxyoxan-2-one Inhibitor Inhibition 8.75
(3R,5R)-7-[5-(3-fluorophenyl)-1-(4-fluorophenyl)-4-oxo-3-(propan-2-yl)-3H,4H,5H-pyrrolo[2,3-c]quinolin-2-yl]-3,5-dihydroxyheptanoate Inhibitor Inhibition 8.72
(3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid Inhibitor Inhibition 8.51
rosuvastatin Inhibitor Competitive 8.51
(4R)-6-[(E)-2-[4-(4-fluorophenyl)-2,6-bis(propan-2-yl)pyrimidin-5-yl]ethenyl]-4-hydroxyoxan-2-one Inhibitor Inhibition 8.32
(3R,5R,6E)-7-[4,5-bis(4-fluorophenyl)-2-(propan-2-yl)-1H-imidazol-1-yl]-3,5-dihydroxyhept-6-enoic acid Inhibitor Inhibition 8.24
atorvastatin Inhibitor Competitive 8.22
(3R,6E)-7-[5-(4-fluorophenyl)-3-(propan-2-yl)-1-(pyrazin-2-yl)-1H-pyrazol-4-yl]-3,5-dihydroxyhept-6-enoate Inhibitor Inhibition 8.16
(3R,5S,6E)-7-[2,3-bis(4-fluorophenyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyhept-6-enoic acid Inhibitor Inhibition 8.16
(3R,5R)-7-[(1S,2S,3R,6S)-2-{[(2,2-dimethylbutanoyl)oxy]methyl}-6-methyl-3-propylcyclohexyl]-3,5-dihydroxyheptanoic acid Inhibitor Inhibition 8.1
cerivastatin Inhibitor Competitive 8
simvastatin Inhibitor Competitive 7.92
(3R)-7-[(1S,2S,6R,8S,8aR)-2,6-dimethyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate Inhibitor Inhibition 7.7
lovastatin Inhibitor Competitive 7.69
mevastatin Inhibitor Competitive 7.64
fluvastatin Inhibitor Competitive 7.55
DFGYVAE Inhibitor Competitive 7.29
(3R)-6-{[2-(4-fluorophenyl)-4-(propan-2-yl)quinolin-3-yl]oxy}-3,5-dihydroxyhexanoate Inhibitor Inhibition 6.6
(1S,3Z)-3-{2-[(1R,3aS,7aR)-1-(6-hydroxy-6-methylheptan-2-yl)-7a-methyl-octahydro-1H-inden-4-yl]ethylidene}-4,4-dimethylcyclohexan-1-ol Inhibitor Inhibition 6.52
(4R)-6-{2-[4-(4-fluorophenyl)-6-phenyl-2-(propan-2-yl)pyridin-3-yl]ethyl}-4-hydroxyoxan-2-one Inhibitor Inhibition 6.43
(5E)-octadec-5-en-7,9-diynoic acid Inhibitor Inhibition 6.3
1-[17-(1,5-Dimethyl-hexyl)-3-hydroxy-4,4,10,13-tetramethyl-1,2,3,4,5,6,9,10,11,12,13,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-14-yl]-ethanone Inhibitor Inhibition 6
(1S,3R,4aR,7S,8S,8aS)-3-hydroxy-8-{2-[(4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-7-methyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl (2S)-2-methylbutanoate Inhibitor Inhibition 5.85
(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-amino-3-phenylpropanoyl]pyrrolidin-2-yl]formamido}-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]pentanedioic acid Inhibitor Inhibition 5.83
4-[3-(dodeca-1,3-diyn-1-yl)oxiran-2-yl]butanoic acid Inhibitor Inhibition 5.3
(3S)-3-{[(2S)-1-[(2S)-2-(2-aminoacetamido)-4-methylpentanoyl]pyrrolidin-2-yl]formamido}-3-({[(carboxymethyl)carbamoyl]methyl}carbamoyl)propanoic acid Inhibitor Inhibition 4.65
pravastatin None None

(134) Novoseek inferred chemical compound relationships for HMGCR Gene

Compound -log(P) Hits PubMed IDs
simvastatin 95.9 146
pravastatin 95.6 119
mevalonate 95.3 119
lovastatin 95.3 121
fluvastatin 93.4 124

(6) PharmGKB related drug/compound annotations for HMGCR Gene

genes like me logo Genes that share compounds with HMGCR: view

Transcripts for HMGCR Gene

Unigene Clusters for HMGCR Gene

3-hydroxy-3-methylglutaryl-CoA reductase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMGCR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b
SP1: - - - -
SP2: - - -
SP3:
SP4:
SP5:

Relevant External Links for HMGCR Gene

GeneLoc Exon Structure for
HMGCR
ECgene alternative splicing isoforms for
HMGCR

Expression for HMGCR Gene

mRNA expression in normal human tissues for HMGCR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMGCR Gene

SOURCE GeneReport for Unigene cluster for HMGCR Gene Hs.628096

genes like me logo Genes that share expressions with HMGCR: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HMGCR Gene

Orthologs for HMGCR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HMGCR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMGCR 35
  • 99.7 (n)
  • 99.77 (a)
HMGCR 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HMGCR 35
  • 90.92 (n)
  • 95.38 (a)
HMGCR 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HMGCR 35
  • 92.23 (n)
  • 95.72 (a)
HMGCR 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmgcr 35
  • 86.55 (n)
  • 93.57 (a)
Hmgcr 16
Hmgcr 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HMGCR 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HMGCR 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hmgcr 35
  • 86.13 (n)
  • 92.9 (a)
chicken
(Gallus gallus)
Aves HMGCR 35
  • 79.09 (n)
  • 86.29 (a)
HMGCR 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HMGCR 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397750 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hmgcr 35
  • 74.99 (n)
  • 82.18 (a)
Str.16151 35
zebrafish
(Danio rerio)
Actinopterygii hmgcra 35
  • 70.29 (n)
  • 78.34 (a)
hmgcra 36
  • 78 (a)
OneToMany
hmgcrb 36
  • 71 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002288 35
  • 51.83 (n)
  • 50.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hmgcr 35
  • 53.44 (n)
  • 51.14 (a)
Hmgcr 36
  • 45 (a)
OneToOne
Hmgcr 37
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea hmgr-1 35
  • 54 (n)
  • 48.16 (a)
hmgr-1 36
  • 42 (a)
OneToOne
F08F8.2 37
  • 46 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER152W 35
  • 46.31 (n)
  • 42.4 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMG1 36
  • 32 (a)
OneToMany
HMG2 35
  • 57.36 (n)
  • 59.15 (a)
HMG2 36
  • 32 (a)
OneToMany
HMG2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04642g 35
  • 48.99 (n)
  • 42.97 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10817 35
soybean
(Glycine max)
eudicotyledons Gma.4589 35
thale cress
(Arabidopsis thaliana)
eudicotyledons HMG1 35
  • 59.33 (n)
  • 57.18 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.5593 35
corn
(Zea mays)
Liliopsida Zm.2360 35
rice
(Oryza sativa)
Liliopsida Os.164 35
Os08g0512700 35
  • 57.4 (n)
  • 57.8 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.1571 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00712 35
  • 58.15 (n)
  • 60.72 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hmg1 35
  • 54.91 (n)
  • 55.05 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2237 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for HMGCR:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for HMGCR Gene

ENSEMBL:
Gene Tree for HMGCR (if available)
TreeFam:
Gene Tree for HMGCR (if available)

Paralogs for HMGCR Gene

No data available for Paralogs for HMGCR Gene

Variants for HMGCR Gene

Sequence variations from dbSNP and Humsavar for HMGCR Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs5908 - 75,356,374(+) CAAGT(A/G)TAGCT reference, missense
rs5909 -- 75,360,350(+) AGCCC(A/G)ACAGT utr-variant-3-prime
rs6805 -- 75,361,459(+) TTTAA(A/T)GTTGT utr-variant-3-prime
rs12916 -- 75,360,714(+) CTCAC(C/T)CCTGC utr-variant-3-prime
rs1044453 -- 75,360,449(+) GAATA(A/G)ATGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HMGCR Gene

Variant ID Type Subtype PubMed ID
nsv882192 CNV Loss 21882294
esv268588 CNV Insertion 20981092
dgv6183n71 CNV Loss 21882294

Relevant External Links for HMGCR Gene

HapMap Linkage Disequilibrium report
HMGCR
Human Gene Mutation Database (HGMD)
HMGCR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGCR Gene

Disorders for HMGCR Gene

(95) Novoseek inferred disease relationships for HMGCR Gene

Disease -log(P) Hits PubMed IDs
hypercholesterolemia 90.7 117
rhabdomyolysis 81.8 60
hyperlipidemia 79.9 70
dyslipidemia 79.2 63
coronary heart disease 77.5 69

Relevant External Links for HMGCR

Genetic Association Database (GAD)
HMGCR
Human Genome Epidemiology (HuGE) Navigator
HMGCR
genes like me logo Genes that share disorders with HMGCR: view

No data available for UniProtKB/Swiss-Prot for HMGCR Gene

Publications for HMGCR Gene

  1. Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. (PMID: 12535518) Sever N. … DeBose-Boyd R.A. (Mol. Cell 2003) 3 4 23
  2. 8302A/C and (TTA)n polymorphisms in the HMG-CoA reductase gene may be associated with some plasma lipid metabolic phenotypes in patients with coronary heart disease. (PMID: 15233402) Tong Y. … Shi J.J. (Lipids 2004) 3 23 48
  3. Effect of ScrF I polymorphism in the 2nd intron of the HMGCR gene on lipid-lowering response to simvastatin in Chinese diabetic patients. (PMID: 17870053) Ying S. … Gao Y.Y. (Biochem. Biophys. Res. Commun. 2007) 3 23 48
  4. Acute myocardial infarction and proinflammatory gene variants. (PMID: 18056971) Licastro F. … Corder E.H. (Ann. N. Y. Acad. Sci. 2007) 3 23 48
  5. Common genetic variation in six lipid-related and statin-related genes, statin use and risk of incident nonfatal myocardial infarction and stroke. (PMID: 18622260) Hindorff L.A. … Psaty B.M. (Pharmacogenet. Genomics 2008) 3 23 48

Products for HMGCR Gene

  • Addgene plasmids for HMGCR

Sources for HMGCR Gene

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