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Aliases for HMGCR Gene

Aliases for HMGCR Gene

  • 3-Hydroxy-3-Methylglutaryl-CoA Reductase 2 3 5
  • 3-Hydroxy-3-Methylglutaryl CoA Reductase (NADPH) 2 3
  • Hydroxymethylglutaryl-CoA Reductase 2 3
  • HMG-CoA Reductase 3 4
  • EC 1.1.1.34 4 63
  • 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase 2
  • EC 1.1.1 63
  • LDLCQ3 3

External Ids for HMGCR Gene

Previous GeneCards Identifiers for HMGCR Gene

  • GC05P073440
  • GC05P074869
  • GC05P074671
  • GC05P074717
  • GC05P074668
  • GC05P069838
  • GC05P074635

Summaries for HMGCR Gene

Entrez Gene Summary for HMGCR Gene

  • HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

GeneCards Summary for HMGCR Gene

HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase) is a Protein Coding gene. Diseases associated with HMGCR include Cerebrotendinous Xanthomatosis and Lichen Planus Pemphigoides. Among its related pathways are Terpenoid backbone biosynthesis and Regulation of cholesterol biosynthesis by SREBP (SREBF). GO annotations related to this gene include protein homodimerization activity and NADP binding.

UniProtKB/Swiss-Prot for HMGCR Gene

  • Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Tocris Summary for HMGCR Gene

  • 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase) catalyzes the rate limiting step in cholesterol biosynthesis - conversion of 3-hydroxy-3-methyl-glutaryl-CoA to mevalonic acid. HMG-CoA reductase is a transmembrane enzyme, bound to endoplasmic reticulum.

Gene Wiki entry for HMGCR Gene

PharmGKB "VIP" Summary for HMGCR Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for HMGCR Gene

Genomics for HMGCR Gene

Regulatory Elements for HMGCR Gene

Enhancers for HMGCR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HMGCR on UCSC Golden Path with GeneCards custom track

Promoters for HMGCR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HMGCR on UCSC Golden Path with GeneCards custom track

Genomic Location for HMGCR Gene

Chromosome:
5
Start:
75,336,329 bp from pter
End:
75,362,104 bp from pter
Size:
25,776 bases
Orientation:
Plus strand

Genomic View for HMGCR Gene

Genes around HMGCR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMGCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMGCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGCR Gene

Proteins for HMGCR Gene

  • Protein details for HMGCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04035-HMDH_HUMAN
    Recommended name:
    3-hydroxy-3-methylglutaryl-coenzyme A reductase
    Protein Accession:
    P04035
    Secondary Accessions:
    • B7Z3Y9
    • Q8N190

    Protein attributes for HMGCR Gene

    Size:
    888 amino acids
    Molecular mass:
    97476 Da
    Quaternary structure:
    • Homodimer. Interacts (via its SSD) with INSIG1; the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Interacts with UBIAD1.
    SequenceCaution:
    • Sequence=BAH12375.1; Type=Frameshift; Positions=122; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HMGCR Gene

    Alternative splice isoforms for HMGCR Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HMGCR Gene

Proteomics data for HMGCR Gene at MOPED

Post-translational modifications for HMGCR Gene

  • N-glycosylated. Deglycosylated by NGLY1 on release from the endoplasmic reticulum (ER) in a sterol-mediated manner.
  • Undergoes sterol-mediated ubiquitination and ER-association degradation (ERAD). Accumulation of sterols in the endoplasmic reticulum (ER) membrane, triggers binding of the reductase to the ER membrane protein INSIG1. This INSIG1 binding leads to the recruitment of the ubiquitin ligase, AMFR/gp78, initiating ubiquitination of the reductase. The ubiquitinated reductase is then extracted from the ER membrane and delivered to cytosolic 26S proteosomes by a mechanism probably mediated by the ATPase Valosin-containing protein VCP/p97. Lys-248 is the main site of ubiquitination. Ubiquitination is enhanced by the presence of a geranylgeranylated protein.
  • Ubiquitination at Lys 89, Lys 248, Lys 288, Lys 299, Lys 381, Lys 401, Lys 460, Lys 474, Lys 480, Lys 619, Lys 633, Lys 662, Lys 704, Lys 715, Lys 864, and Lys 873
  • Glycosylation at Asn 281, Asn 296, Asn 419, Asn 518, and Asn 870
  • Modification sites at PhosphoSitePlus

Domains & Families for HMGCR Gene

Gene Families for HMGCR Gene

Suggested Antigen Peptide Sequences for HMGCR Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04035

UniProtKB/Swiss-Prot:

HMDH_HUMAN :
  • Contains 1 SSD (sterol-sensing) domain.
  • Belongs to the HMG-CoA reductase family.
Domain:
  • Contains 1 SSD (sterol-sensing) domain.
Family:
  • Belongs to the HMG-CoA reductase family.
genes like me logo Genes that share domains with HMGCR: view

Function for HMGCR Gene

Molecular function for HMGCR Gene

GENATLAS Biochemistry:
3-hydroxy-3-methylglutaryl-CoA reductase,catalyzing a rate-limiting step in cholesterol biosynthesis
UniProtKB/Swiss-Prot CatalyticActivity:
(R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.
UniProtKB/Swiss-Prot EnzymeRegulation:
Regulated by a negative feedback mechanism through sterols and non-sterol metabolites derived from mevalonate. Inhibited by statins, a class of hypolipidemic agents used as pharmaceuticals to lower cholesterol levels in individuals at risk from cardiovascular disease due to hypercholesterolemia. Inhibition of HMGCR in the liver stimulates the LDL-receptors, which results in an increased clearance of LDL from the bloodstream and a decrease in blood cholesterol levels. The first results can be seen after one week of statin use and the effect is maximal after four to six weeks.
UniProtKB/Swiss-Prot Function:
Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

Enzyme Numbers (IUBMB) for HMGCR Gene

Gene Ontology (GO) - Molecular Function for HMGCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23169578
genes like me logo Genes that share ontologies with HMGCR: view
genes like me logo Genes that share phenotypes with HMGCR: view

Animal Models for HMGCR Gene

MGI Knock Outs for HMGCR:

Animal Model Products

  • Taconic Biosciences Mouse Models for HMGCR

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HMGCR Gene

Localization for HMGCR Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGCR Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMGCR Gene COMPARTMENTS Subcellular localization image for HMGCR gene
Compartment Confidence
endoplasmic reticulum 5
peroxisome 5
plasma membrane 4
extracellular 3
cytosol 2
mitochondrion 2
nucleus 2
cytoskeleton 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for HMGCR Gene

Pathways & Interactions for HMGCR Gene

genes like me logo Genes that share pathways with HMGCR: view

UniProtKB/Swiss-Prot P04035-HMDH_HUMAN

  • Pathway: Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.

Gene Ontology (GO) - Biological Process for HMGCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006695 cholesterol biosynthetic process TAS --
GO:0006743 ubiquinone metabolic process IEA --
GO:0007568 aging IEA --
GO:0008299 isoprenoid biosynthetic process IEA,IBA --
GO:0010664 negative regulation of striated muscle cell apoptotic process IEA --
genes like me logo Genes that share ontologies with HMGCR: view

No data available for SIGNOR curated interactions for HMGCR Gene

Drugs & Compounds for HMGCR Gene

(125) Drugs for HMGCR Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lovastatin Approved, Investigational Pharma Competitive, Inhibitor, inhibitor, Target HMG-CoA reductase inhibitor, Potent HMG-CoA reductase inhibitor 59
Simvastatin Approved Pharma Competitive, Inhibitor, inhibitor, Target HMG-CoA reductase inhibitor 499
atorvastatin Approved Pharma Competitive, Inhibitor, inhibitor, Target 0
Pravastatin Approved Pharma Competitive, Inhibitor, inhibitor, Target 145
Fluvastatin Approved Pharma Competitive, Inhibitor, inhibitor, Target 58

(64) Additional Compounds for HMGCR Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-hydroxy-3-methylglutaryl-coa
  • (S)-3-hydroxy-3-methylglutaryl-CoA
  • (S)-3-hydroxy-3-methylglutaryl-Coenzyme A
  • 3-Hydroxy-3-methyl-Glutaryl-CoA
  • 3-Hydroxy-3-methyl-Glutaryl-Coenzyme A
  • 3-Hydroxy-3-methylglutaryl-CoA
1553-55-5
6-Hydroxyfluvastatin
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
Mevalonic acid
  • (3RS)-Mevalonate
  • (3RS)-Mevalonic acid
  • 2,4-Dideoxy-3-C-methylpentonate
  • 2,4-Dideoxy-3-C-methylpentonic acid
  • 3,5-Dihydroxy-3-methyl-Valerate
150-97-0
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8

(5) Tocris Compounds for HMGCR Gene

Compound Action Cas Number
Fluvastatin sodium Potent HMG-CoA reductase inhibitor 93957-55-2
Lovastatin Potent HMG-CoA reductase inhibitor 75330-75-5
Mevastatin HMG-CoA reductase inhibitor 73573-88-3
Pravastatin sodium salt HMG-CoA reductase inhibitor 81131-70-6
Simvastatin HMG-CoA reductase inhibitor 79902-63-9

(9) ApexBio Compounds for HMGCR Gene

Compound Action Cas Number
Atorvastatin Calcium HMG-CoA reductase inhibitor 134523-03-8
Clinofibrate HMGCR inhibitor 30299-08-2
Fluvastatin (Lescol) 93957-55-2
Lovastatin HMG-CoA reductase inhibitor 75330-75-5
Mevastatin HMG-CoA reductase inhibitor 73573-88-3
Pitavastatin Calcium Enzyme HMGCR inhibitor 147526-32-7
Pravastatin sodium HMG-CoA reductase inhibitor,highly selective and competitive 81131-70-6
Rosuvastatin Calcium 147098-20-2
Simvastatin (Zocor) HMGCR (HMG-CoA reductase) inhibitor 79902-63-9
genes like me logo Genes that share compounds with HMGCR: view

Drug Products

Transcripts for HMGCR Gene

Unigene Clusters for HMGCR Gene

3-hydroxy-3-methylglutaryl-CoA reductase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMGCR Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b
SP1: - - - -
SP2: - - -
SP3:
SP4:
SP5:

Relevant External Links for HMGCR Gene

GeneLoc Exon Structure for
HMGCR
ECgene alternative splicing isoforms for
HMGCR

Expression for HMGCR Gene

mRNA expression in normal human tissues for HMGCR Gene

Protein differential expression in normal tissues from HIPED for HMGCR Gene

This gene is overexpressed in Fetal testis (62.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMGCR Gene



SOURCE GeneReport for Unigene cluster for HMGCR Gene Hs.628096

genes like me logo Genes that share expression patterns with HMGCR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HMGCR Gene

Orthologs for HMGCR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HMGCR Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HMGCR 35
  • 90.92 (n)
  • 95.38 (a)
HMGCR 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HMGCR 35
  • 92.23 (n)
  • 95.72 (a)
HMGCR 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmgcr 35
  • 86.55 (n)
  • 93.57 (a)
Hmgcr 16
Hmgcr 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HMGCR 35
  • 99.7 (n)
  • 99.77 (a)
HMGCR 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hmgcr 35
  • 86.13 (n)
  • 92.9 (a)
oppossum
(Monodelphis domestica)
Mammalia HMGCR 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HMGCR 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves HMGCR 35
  • 79.09 (n)
  • 86.29 (a)
HMGCR 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HMGCR 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hmgcr 35
  • 74.99 (n)
  • 82.18 (a)
Str.16151 35
African clawed frog
(Xenopus laevis)
Amphibia LOC397750 35
zebrafish
(Danio rerio)
Actinopterygii hmgcra 35
  • 70.29 (n)
  • 78.34 (a)
hmgcra 36
  • 78 (a)
OneToMany
hmgcrb 36
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Hmgcr 37
  • 44 (a)
Hmgcr 35
  • 53.44 (n)
  • 51.14 (a)
Hmgcr 36
  • 45 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002288 35
  • 51.83 (n)
  • 50.53 (a)
worm
(Caenorhabditis elegans)
Secernentea F08F8.2 37
  • 46 (a)
hmgr-1 35
  • 54 (n)
  • 48.16 (a)
hmgr-1 36
  • 42 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER152W 35
  • 46.31 (n)
  • 42.4 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04642g 35
  • 48.99 (n)
  • 42.97 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HMG2 35
  • 57.36 (n)
  • 59.15 (a)
HMG1 36
  • 32 (a)
OneToMany
HMG2 36
  • 32 (a)
OneToMany
HMG2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons HMG1 35
  • 59.33 (n)
  • 57.18 (a)
soybean
(Glycine max)
eudicotyledons Gma.4589 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10817 35
barley
(Hordeum vulgare)
Liliopsida Hv.5593 35
rice
(Oryza sativa)
Liliopsida Os.164 35
Os08g0512700 35
  • 57.4 (n)
  • 57.8 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.1571 35
corn
(Zea mays)
Liliopsida Zm.2360 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2237 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00712 35
  • 58.15 (n)
  • 60.72 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hmg1 35
  • 54.91 (n)
  • 55.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for HMGCR:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for HMGCR Gene

ENSEMBL:
Gene Tree for HMGCR (if available)
TreeFam:
Gene Tree for HMGCR (if available)

Paralogs for HMGCR Gene

No data available for Paralogs for HMGCR Gene

Variants for HMGCR Gene

Sequence variations from dbSNP and Humsavar for HMGCR Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs5908 - 75,356,374(+) CAAGT(A/G)TAGCT reference, missense
rs5909 -- 75,360,350(+) AGCCC(A/G)ACAGT utr-variant-3-prime
rs6805 -- 75,361,459(+) TTTAA(A/T)GTTGT utr-variant-3-prime
rs12916 -- 75,360,714(+) CTCAC(C/T)CCTGC utr-variant-3-prime
rs2878419 -- 75,344,665(+) TGGCA(C/T)GATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMGCR Gene

Variant ID Type Subtype PubMed ID
nsv882192 CNV Loss 21882294
esv268588 CNV Insertion 20981092
dgv6183n71 CNV Loss 21882294

Variation tolerance for HMGCR Gene

Residual Variation Intolerance Score: 6.91% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 26.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HMGCR Gene

Human Gene Mutation Database (HGMD)
HMGCR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGCR Gene

Disorders for HMGCR Gene

MalaCards: The human disease database

(30) MalaCards diseases for HMGCR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cerebrotendinous xanthomatosis
  • cholestanol storage disease
lichen planus pemphigoides
  • lp pemphigoides
hyperlipidemia, familial combined
  • combined hyperlipidemia, familial
atherosclerosis
  • arteriosclerosis
familial hyperlipidemia
  • familial hyperlipoproteinemia
- elite association - COSMIC cancer census association via MalaCards
Search HMGCR in MalaCards View complete list of genes associated with diseases

Relevant External Links for HMGCR

Genetic Association Database (GAD)
HMGCR
Human Genome Epidemiology (HuGE) Navigator
HMGCR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HMGCR
genes like me logo Genes that share disorders with HMGCR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HMGCR Gene

Publications for HMGCR Gene

  1. Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13. (PMID: 18802019) Burkhardt R. … Breslow J.L. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 23 48 67
  2. New dimension of statin action on ApoB atherogenicity. (PMID: 12539816) Chapman M.J. … McTaggart F. (Clin Cardiol 2003) 23 25 26
  3. Rosuvastatin: a highly efficacious statin for the treatment of dyslipidaemia. (PMID: 11772327) Davidson M.H. (Expert Opin Investig Drugs 2002) 23 25 26
  4. Rosuvastatin: a highly effective new HMG-CoA reductase inhibitor. (PMID: 12481202) Olsson A.G. … Raza A. (Cardiovasc Drug Rev 2002) 23 25 26
  5. Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. (PMID: 11256847) McTaggart F. … Warwick M. (Am. J. Cardiol. 2001) 23 25 26

Products for HMGCR Gene

Sources for HMGCR Gene

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