Aliases for HMGB4 Gene
Aliases for HMGB4 Gene
External Ids for HMGB4 Gene
- HGNC: 24954
- Entrez Gene: 127540
- Ensembl: ENSG00000176256
- OMIM: 617285
- UniProtKB: Q8WW32
Previous GeneCards Identifiers for HMGB4 Gene
- GC01P033996
- GC01P034098
- GC01P034326
- GC01P032442
Summaries for HMGB4 Gene
GeneCards Summary for HMGB4 Gene
HMGB4 (High Mobility Group Box 4) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is HMGB2.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGB4 Gene
Genomics for HMGB4 Gene
Regulatory Elements for HMGB4 Gene
Enhancers for HMGB4 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G033903 | 0.6 | FANTOM5 | 21.9 | +42.9 | 42945 | 0.3 | MTA2 MAFG TBX21 YY1 JUND ZNF316 ATF3 NFE2 HNF4A | HMGB4 CSMD2-AS1 GC01M033889 GC01P033929 |
| GH01G033996 | 0.3 | FANTOM5 | 2.6 | +136.6 | 136564 | 0.4 | CSMD2 HMGB4 GC01M033964 GC01M034025 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HMGB4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HMGB4 gene promoter:
Regulatory Element Products
Genomic Location for HMGB4 Gene
- Chromosome:
- 1
- Start:
- 33,860,475 bp from pter
- End:
- 33,864,791 bp from pter
- Size:
- 4,317 bases
- Orientation:
- Plus strand
Genomic View for HMGB4 Gene
Genes around HMGB4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p35.1 by Ensembl
- 1p35.1 by Entrez Gene
- 1p35.1 by HGNC
HMGB4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMGB4 Gene
Proteins for HMGB4 Gene
-
Protein details for HMGB4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8WW32-HMGB4_HUMAN
- Recommended name:
- High mobility group protein B4
- Protein Accession:
- Q8WW32
- B2R4X7
- Q0QWA4
Protein attributes for HMGB4 Gene
- Size:
- 186 amino acids
- Molecular mass:
- 22490 Da
- Quaternary structure:
- No Data Available
Protein Expression for HMGB4 Gene
Post-translational modifications for HMGB4 Gene
Other Protein References for HMGB4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HMGB4
-
Abcam antibodies for HMGB4
-
Cloud-Clone Corp. Antibodies for HMGB4
- Invitrogen Antibodies for HMGB4
- GeneTex HMGB4 antibody for HMGB4
Protein Products
-
OriGene Purified Proteins for HMGB4
- Search Origene for MassSpec and Protein Over-expression Lysates for HMGB4
- Origene Custom Protein Services for HMGB4
-
Cloud-Clone Corp. Proteins for HMGB4
- Search GeneTex for Proteins for HMGB4
-
Abcam proteins for HMGB4
Assay Products
No data available for DME Specific Peptides for HMGB4 Gene
Domains & Families for HMGB4 Gene
Gene Families for HMGB4 Gene
Protein Domains for HMGB4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HMGB4 Gene
Graphical View of Domain Structure for InterPro Entry
Q8WW32- Family:
-
- Belongs to the HMGB family.
Function for HMGB4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for HMGB4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HMGB4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGB4 gene
- Search ViGene Biosciences for HMGB4
CRISPR Products
-
OriGene CRISPR knockouts for HMGB4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGB4
- GenScript: Design CRISPR guide RNA sequences for HMGB4
miRNA Products
- Search ViGene Biosciences for HMGB4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HMGB4
- Browse OriGene Inhibitory RNA Products For HMGB4
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGB4 gene
Cell Line Products
-
Horizon Cell Lines for HMGB4
-
ViGene Biosciences adenoviral particle packaged cDNA for HMGB4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HMGB4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGB4 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HMGB4 Gene
Localization for HMGB4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HMGB4 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 21630459 |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for HMGB4 Gene
No Data Available
Interacting Proteins for HMGB4 Gene
Selected Interacting proteins:
ENSP00000429214
Q8WW32-HMGB4_HUMAN
for HMGB4 Gene via
STRING
IID
UniProtKB
No data available for Pathways by source and SIGNOR curated interactions for HMGB4 Gene
Transcripts for HMGB4 Gene
mRNA/cDNA for HMGB4 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (87) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HMGB4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HMGB4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGB4
- GenScript: Design CRISPR guide RNA sequences for HMGB4
miRNA Products
- Search ViGene Biosciences for HMGB4
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HMGB4
- Browse OriGene Inhibitory RNA Products For HMGB4
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGB4 gene
Flow Cytometry Products
Expression for HMGB4 Gene
mRNA differential expression in normal tissues according to GTEx for HMGB4 Gene
This gene is overexpressed in Testis (x52.6).
This gene is overexpressed in Testis (50.9) and Ovary (18.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HMGB4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HMGB4 Gene:
HMGB4SOURCE GeneReport for Unigene cluster for HMGB4 Gene:
Hs.568628Primer Products
-
OriGene qPCR primer pairs and template standards for HMGB4
-
OriGene qPCR primer pairs for HMGB4
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMGB4 Gene
Orthologs for HMGB4 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HMGB4 34 |
|
||
| cow (Bos Taurus) |
Mammalia | HMGB4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HMGB4 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hmgb4 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hmgb4 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HMGB4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | hmgb2b 35 |
|
ManyToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | Dsp1 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | hmg-1.1 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NHP6A 35 |
|
ManyToMany | |
| NHP6B 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3845 35 |
|
OneToMany |
- Species where no ortholog for HMGB4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for HMGB4 Gene
Variants for HMGB4 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000455122 | -- | 33,862,573(+) | AAAAG(C/G)CTACC | intron-variant, upstream-variant-2KB | |
| rs1001379989 | -- | 33,859,571(+) | GTTTC(A/G)GGGCT | intron-variant, upstream-variant-2KB | |
| rs1002234808 | -- | 33,864,391(+) | ACTCG(A/T)CAAAG | intron-variant, nc-transcript-variant, reference, missense | |
| rs1002952576 | -- | 33,861,473(+) | CTCAT(A/C)ATCTA | intron-variant | |
| rs1003016296 | -- | 33,860,861(+) | CATTC(C/T)TGGAG | intron-variant, utr-variant-5-prime |
Residual Variation Intolerance Score:
78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.07;
37.86% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HMGB4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HMGB4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGB4 Gene
Disorders for HMGB4 Gene
Relevant External Links for HMGB4
No disorders were found for HMGB4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMGB4 Gene
Publications for HMGB4 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
- Protein array based interactome analysis of amyloid-I^ indicates an inhibition of protein translation. (PMID: 21244100) Virok D.P. … FA1lAPp L. (J. Proteome Res. 2011) 3 64
- Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3 64
Products for HMGB4 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HMGB4
- Search Origene for MassSpec and Protein Over-expression Lysates for HMGB4
- Origene Custom Protein Services for HMGB4
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HMGB4
- Browse OriGene Inhibitory RNA Products For HMGB4
- OriGene qPCR primer pairs and template standards for HMGB4
- OriGene qPCR primer pairs for HMGB4
- OriGene CRISPR knockouts for HMGB4
- OriGene ORF clones in human for HMGB4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HMGB4
- GenScript: Next-day shipping cDNA ORF clone for HMGB4 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HMGB4
- GenScript Custom Assay Services for HMGB4
- GenScript Custom overexpressing Cell Line Services for HMGB4
- GenScript: Design CRISPR guide RNA sequences for HMGB4
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HMGB4
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HMGB4
- Novus Biologicals proteins and lysates for HMGB4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for HMGB4
- Abcam proteins for HMGB4
- Search for Assays for HMGB4 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Cloud-Clone Corp. Antibodies for HMGB4
- Cloud-Clone Corp. Proteins for HMGB4
- Browse Assay Kits at Cloud-Clone Corp.
- ViGene Biosciences adenoviral particle packaged cDNA for HMGB4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HMGB4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HMGB4 gene
- Search ViGene Biosciences for HMGB4
- Horizon Cell Lines for HMGB4
- Cyagen custom Knockout/knockin (KOKI) mouse models for HMGB4
- VectorBuilder custom plasmid, inducible vectors for HMGB4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HMGB4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HMGB4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer