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Aliases for HMGB4 Gene

Aliases for HMGB4 Gene

  • High Mobility Group Box 4 2 3
  • High Mobility Group Protein B4 3
  • High-Mobility Group Box 4 2
  • DJ1007G16.5 3
  • HMG2 Like 3

External Ids for HMGB4 Gene

Previous GeneCards Identifiers for HMGB4 Gene

  • GC01P033996
  • GC01P034098
  • GC01P034326
  • GC01P032442

Summaries for HMGB4 Gene

GeneCards Summary for HMGB4 Gene

HMGB4 (High Mobility Group Box 4) is a Protein Coding gene. An important paralog of this gene is HMGB1.

Gene Wiki entry for HMGB4 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGB4 Gene

Genomics for HMGB4 Gene

Regulatory Elements for HMGB4 Gene

Genomic Location for HMGB4 Gene

Start:
33,860,475 bp from pter
End:
33,864,791 bp from pter
Size:
4,317 bases
Orientation:
Plus strand

Genomic View for HMGB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMGB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGB4 Gene

Proteins for HMGB4 Gene

  • Protein details for HMGB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW32-HMGB4_HUMAN
    Recommended name:
    High mobility group protein B4
    Protein Accession:
    Q8WW32
    Secondary Accessions:
    • B2R4X7
    • Q0QWA4

    Protein attributes for HMGB4 Gene

    Size:
    186 amino acids
    Molecular mass:
    22490 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HMGB4 Gene

Proteomics data for HMGB4 Gene at MOPED

Post-translational modifications for HMGB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HMGB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HMGB4 Gene

Domains for HMGB4 Gene

Gene Families for HMGB4 Gene

HGNC:
  • HMG :High-mobility group / Canonical

Protein Domains for HMGB4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WW32

UniProtKB/Swiss-Prot:

HMGB4_HUMAN :
  • Q8WW32
Domain:
  • Contains 2 HMG box DNA-binding domains.
Family:
  • Belongs to the HMGB family.
genes like me logo Genes that share domains with HMGB4: view

Function for HMGB4 Gene

Gene Ontology (GO) - Molecular Function for HMGB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with HMGB4: view

Phenotypes for HMGB4 Gene

genes like me logo Genes that share phenotypes with HMGB4: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HMGB4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HMGB4 Gene

Localization for HMGB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGB4 Gene

Nucleus. Chromosome.

Gene Ontology (GO) - Cellular Components for HMGB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with HMGB4: view

No data available for Subcellular locations from COMPARTMENTS for HMGB4 Gene

Pathways for HMGB4 Gene

SuperPathways for HMGB4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HMGB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IBA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with HMGB4: view

No data available for Pathways by source for HMGB4 Gene

Transcripts for HMGB4 Gene

Unigene Clusters for HMGB4 Gene

High mobility group box 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HMGB4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HMGB4 Gene

No ASD Table

Relevant External Links for HMGB4 Gene

GeneLoc Exon Structure for
HMGB4
ECgene alternative splicing isoforms for
HMGB4

Expression for HMGB4 Gene

mRNA expression in normal human tissues for HMGB4 Gene

mRNA differential expression in normal tissues according to GTEx for HMGB4 Gene

This gene is overexpressed in Testis (52.6).

Protein differential expression in normal tissues for HMGB4 Gene

This gene is overexpressed in Testis (50.9) and Ovary (18.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HMGB4 Gene

SOURCE GeneReport for Unigene cluster for HMGB4 Gene Hs.568628

genes like me logo Genes that share expressions with HMGB4: view

Expression partners for HMGB4 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HMGB4 Gene

Orthologs for HMGB4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HMGB4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HMGB4 35
  • 86.96 (n)
  • 84.36 (a)
HMGB4 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HMGB4 35
  • 82.87 (n)
  • 82.32 (a)
HMGB4 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmgb4 35
  • 78.97 (n)
  • 78.57 (a)
Hmgb4 16
Hmgb4 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HMGB4 35
  • 98.75 (n)
  • 96.77 (a)
rat
(Rattus norvegicus)
Mammalia Hmgb4 35
  • 77.44 (n)
  • 75.61 (a)
oppossum
(Monodelphis domestica)
Mammalia HMGB4 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii hmgb2b 36
  • 31 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Dsp1 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hmg-1.1 36
  • 32 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NHP6A 36
  • 33 (a)
ManyToMany
NHP6B 36
  • 32 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3845 36
  • 12 (a)
OneToMany
Species with no ortholog for HMGB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HMGB4 Gene

ENSEMBL:
Gene Tree for HMGB4 (if available)
TreeFam:
Gene Tree for HMGB4 (if available)

Paralogs for HMGB4 Gene

Paralogs for HMGB4 Gene

Selected SIMAP similar genes for HMGB4 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for HMGB4 Gene

genes like me logo Genes that share paralogs with HMGB4: view

Variants for HMGB4 Gene

Sequence variations from dbSNP and Humsavar for HMGB4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
VAR_055951 -
VAR_067467 -
VAR_067468 -

Structural Variations from Database of Genomic Variants (DGV) for HMGB4 Gene

Variant ID Type Subtype PubMed ID
nsv834624 CNV Loss 17160897
nsv871907 CNV Loss 21882294
esv34112 CNV Loss 18971310

Relevant External Links for HMGB4 Gene

HapMap Linkage Disequilibrium report
HMGB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGB4 Gene

Disorders for HMGB4 Gene

Relevant External Links for HMGB4

Human Genome Epidemiology (HuGE) Navigator
HMGB4

No disorders were found for HMGB4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HMGB4 Gene

Publications for HMGB4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A transcript finishing initiative for closing gaps in the human transcriptome. (PMID: 15197164) Sogayar M.C. … Zanette D.L. (Genome Res. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for HMGB4 Gene

Sources for HMGB4 Gene

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