HMGB4 Gene
protein-coding GIFtS: 44
GCID: GC01P034326
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high mobility group box 4(Previous name: high-mobility group box 4 )
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Aliases
for HMGB4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| High Mobility Group Box 41 2 | | FLJ403881 | | High-Mobility Group Box 41 | | DJ1007G16.51 | | High Mobility Group Protein B42 | | HMG2 Like2 |
Export aliases for HMGB4 gene to outside databasesPrevious GC identifers: GC01P033996 GC01P034098 GC01P032442 |
Summaries
for HMGB4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for HMGB4
|
Genomic Views
for HMGB4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HMGB4 gene promoter:
NF-AT2 NF-kappaB1 Cdc5 NF-AT NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HMGB4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMGB4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p35.1 Ensembl cytogenetic band: 1p35.1 HGNC cytogenetic band: 1p35.1HMGB4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P034326: view genomic region
(about GC identifiers)
Start:
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34,326,076 bp from pter |
End:
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34,330,392 bp from pter |
Size:
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4,317 bases |
Orientation:
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plus strand |
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Proteins
for HMGB4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HMGB4_HUMAN, Q8WW32 (See
protein sequence)Recommended Name: High mobility group protein B4 Size: 186 amino acids; 22490 Da
Subcellular location: Nucleus (By similarity). Chromosome (By similarity)
Secondary accessions: B2R4X7 Q0QWA4Explore the universe of human proteins at neXtProt for HMGB4: NX_Q8WW32
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WW32
HMGB4 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_660206.2
ENSEMBL proteins: ENSP00000429214 ENSP00000430919
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
HMGB4 for ontologies About GeneDecksing
HMGB4 Antibody Products:
Assay Products for HMGB4: |
Protein
Domains /
Families
for HMGB4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HMGB4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WW32ProtoNet protein and cluster: Q8WW32 1 Blocks protein family: IPB000135 High mobility group proteins HMG1 and HMG2
UniProtKB/Swiss-Prot: HMGB4_HUMAN, Q8WW32Similarity: Belongs to the HMGB familySimilarity: Contains 2 HMG box DNA-binding domains |
Function
for HMGB4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMGB4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMGB4 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HMGB4 (NM_145205) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HMGB4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMGB4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGB4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- |
HMGB4 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for HMGB4:
|
Pathways & Interactions
for HMGB4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HMGB4
|
Drugs & Compounds
for HMGB4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HMGB4
Search CenterWatch for drugs/clinical trials and news about HMGB4
|
Transcripts
for HMGB4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HMGB4 gene: NM_145205.4 Unigene Cluster for HMGB4: High mobility group box 4 Hs.568628 [show with all ESTs]Unigene Representative Sequence: NM_1452054 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000519684(uc001bxp.3) ENST00000522796 ENST00000458277 ENST00000425537(uc001bxq.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMGB4 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMGB4 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HMGB4 (NM_145205) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HMGB4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMGB4 |
Additional cDNA sequence: AK097707.1 AK130859.1 AK310465.1 AK311985.1 BC021180.2 BC070148.1 DQ207367.1 NR_033264.1 2 DOTS entries: DT.95367635 DT.408782 24/87 AceView cDNA sequences (see all 87): AA629230 AK130859 BP369500 BP371086 BU567351 AI917843 AI634070 BP371463 BU852295 BU567597 BP371397 BP371157 BP370175 BP371217 BP370698 AI655836 AI797725 AI867911 BC021180 BF057167 BE504819 AI968361 BP368976 AI824962
GeneLoc Exon Structure
|
Expression
for HMGB4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HMGB4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAAAAGAAA
About this image
Genevestigator expression for HMGB4
SOURCE GeneReport for Unigene cluster: Hs.568628
SABiosciences Custom PCR Arrays for HMGB4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMGB4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HMGB4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMGB4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMGB4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGB4 |
Orthologs
for HMGB4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for HMGB4 gene from 4/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
fruit fly
(Drosophila melanogaster) |
Insecta |
Dsp16 |
Dorsal switch protein 1 |
15(a) |
1 → many |
X(16227645-16234657) |
worm
(Caenorhabditis elegans) |
Secernentea |
hmg-1.26 |
High mobility group protein 1.2 |
24(a) |
possible ortholog |
III(6280332-6283068) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
NFD6 |
FACT complex subunit SSRP1 |
5(a) |
possible ortholog |
3(10784889-10788729) |
rice
(Oryza sativa) |
Liliopsida |
---- |
SSRP1-like FACT complex subunit, putative, express...SSRP1-like FACT complex subunit, putative, express... |
6(a)5(a) |
possible orthologpossible ortholog |
5(4965403-4971007) 1(4496719-4503407) |
ENSEMBL Gene Tree for HMGB4 (if available)
TreeFam Gene Tree for HMGB4 (if available) |
Paralogs
for HMGB4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HMGB4 gene
- TOX2 TOX42 TOX32 HMGB32 HMGB12 TOX22 HMGB22
11 SIMAP similar genes for HMGB4 using alignment to 2 protein entries: HMGB4_HUMAN (see all proteins):HMG1 DKFZp779G118 HMGB2 HMGB1 HMGB3 HMGB1P1
Bbtx1 TOX2 TOX4 SP100 WUGSC
HMGB4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for HMGB4
PGOHUM00000257054
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Genomic Variants
for HMGB4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HMGB4
1 CNV: 47981 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for HMGB4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HMGB4 for disorders About GeneDecksing
1  disease for HMGB4: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: HMGB4 (1 document)
Export disorders for HMGB4 gene to outside databases
|
Publications
for HMGB4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HMGB4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HMGB4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Convergent Animal and Human Evidence Suggests a Role of PPM1A Gene in Response to Antidepressants. (PubMed id 20970119)1 Malki K....Schalkwyk L.C. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- A transcript finishing initiative for closing gaps in the human transcriptome. (PubMed id 15197164)1 Sogayar M.C....Zanette D.L. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for HMGB4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing HMGB4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HMGB4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HMGB4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HMGB4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HMGB4 gene:
Search GeneIP for patents involving HMGB4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HMGB4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HMGB4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HMGB4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HMGB4 | | | OriGene Protein Over-expression Lysate for HMGB4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HMGB4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HMGB4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HMGB4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HMGB4 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HMGB4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMGB4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HMGB4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMGB4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMGB4 |
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 | | | HMGB4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGB4 |
|  |  |  | | | | Search ThermoFisher Antibodies for HMGB4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMGB4 |
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