Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HMGB3 Gene

protein-coding   GIFtS: 57
GCID: GC0XP150148

High Mobility Group Box 3

(Previous names: high-mobility group (nonhistone chromosomal) protein 4,...)
(Previous symbol: HMG4)
  See HMGB3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
High Mobility Group Box 31 2     High Mobility Group Protein 2a2 3
HMG41 2 3 5     High Mobility Group Protein 42 3
HMG2A2 3 5     HMG-2a2 3
High-Mobility Group (Nonhistone Chromosomal) Protein 41 2     HMG-42 3
High-Mobility Group Box 31 2     High Mobility Group Protein B32
Non-Histone Chromosomal Protein1 2     

External Ids:    HGNC: 50041   Entrez Gene: 31492   Ensembl: ENSG000000299937   OMIM: 3001935   UniProtKB: O153473   

Export aliases for HMGB3 gene to outside databases

Previous GC identifers: GC0XP144450 GC0XP146834 GC0XP147919 GC0XP148792 GC0XP149822 GC0XP139013


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HMGB3 Gene:
HMGB3 belongs to the high mobility group (HMG) protein superfamily. Like HMG1 (MIM 163905) and HMG2 (MIM 163906),
HMGB3 contains DNA-binding HMG box domains and is classified into the HMG box subfamily. Members of the HMG box
subfamily are thought to play a fundamental role in DNA replication, nucleosome assembly and transcription (Wilke
et al., 1997 (PubMed 9370291); Nemeth et al., 2006 (PubMed 16945912)).(supplied by OMIM, Mar 2008)

GeneCards Summary for HMGB3 Gene:
HMGB3 (high mobility group box 3) is a protein-coding gene. Diseases associated with HMGB3 include microphthalmia, syndromic 13, and terminal osseous dysplasia. GO annotations related to this gene include double-stranded DNA binding and DNA binding, bending. An important paralog of this gene is HMGB4.

UniProtKB/Swiss-Prot: HMGB3_HUMAN, O15347
Function: Binds preferentially single-stranded DNA and unwinds double-stranded DNA (By similarity)

Gene Wiki entry for HMGB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011681.17  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HMGB3 gene promoter:
         CBF-C   GATA-1   MEF-2A   IRF-2   CBF-A   CBF-B   IRF-7A   CP1C   CP1A   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHMGB3 promoter sequence
   Search Chromatin IP Primers for HMGB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMGB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

HMGB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMGB3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP150148:  view genomic region     (about GC identifiers)

Start:
150,148,982 bp from pter      End:
150,159,248 bp from pter
Size:
10,267 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HMGB3_HUMAN, O15347 (See protein sequence)
Recommended Name: High mobility group protein B3  
Size: 200 amino acids; 22980 Da
2 PDB 3D structures from and Proteopedia for HMGB3:
2EQZ (3D)        2YQI (3D)    
Secondary accessions: O95556 Q6NS40

Explore the universe of human proteins at neXtProt for HMGB3: NX_O15347

Explore proteomics data for HMGB3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys112
  • Modification sites at PhosphoSitePlus

  • See HMGB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005333.2  
    ENSEMBL proteins: 
     ENSP00000410354   ENSP00000359393   ENSP00000405601   ENSP00000417027   ENSP00000442758  

    HMGB3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HMGB3
    GenScript Custom Purified and Recombinant Proteins Services for HMGB3
    Novus Biologicals HMGB3 Proteins
    Novus Biologicals HMGB3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HMGB3
    Cloud-Clone Corp. Proteins for HMGB3

     
    Search eBioscience for Proteins for HMGB3 

    HMGB3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for HMGB3
    OriGene Antibodies for HMGB3
    OriGene Custom Antibody Services for HMGB3
    Novus Biologicals HMGB3 Antibodies
    Abcam antibodies for HMGB3
    Cloud-Clone Corp. Antibodies for HMGB3
    ThermoFisher Antibodies for HMGB3
    LSBio Antibodies in human, mouse, rat for HMGB3

    HMGB3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HMGB3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HMGB3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HMGB3
    Cloud-Clone Corp. CLIAs for HMGB3
    Search eBioscience for ELISAs for HMGB3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HMG: High-mobility group / Canonical

    2 InterPro protein domains:
     IPR009071 HMG_box_dom
     IPR017967 HMG_boxA_CS

    Graphical View of Domain Structure for InterPro Entry O15347

    ProtoNet protein and cluster: O15347

    1 Blocks protein domain: IPB000135 High mobility group proteins HMG1 and HMG2

    UniProtKB/Swiss-Prot: HMGB3_HUMAN, O15347
    Similarity: Belongs to the HMGB family
    Similarity: Contains 2 HMG box DNA-binding domains


    Find genes that share domains with HMGB3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HMGB3_HUMAN, O15347
    Function: Binds preferentially single-stranded DNA and unwinds double-stranded DNA (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003690double-stranded DNA binding ISS--
    GO:0008301DNA binding, bending ISS--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with HMGB3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for HMGB3:
     Increased G1 DNA content  Increased cell size 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hmgb3):
     hematopoietic system  immune system  normal 

    Find genes that share phenotypes with HMGB3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hmgb3tm1Dmb for HMGB3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HMGB3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HMGB3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HMGB3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HMGB3

    miRNA
    Products:
        
    miRTarBase miRNAs that target HMGB3:
    hsa-mir-21-5p (MIRT031042), hsa-mir-335-5p (MIRT018990), hsa-mir-877-5p (MIRT037218), hsa-mir-148b-3p (MIRT019470), hsa-mir-124-3p (MIRT046106)

    Block miRNA regulation of human, mouse, rat HMGB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HMGB3 (see all 95):
    hsa-miR-579 hsa-miR-3194-5p hsa-miR-106a hsa-miR-128 hsa-miR-3653 hsa-miR-30d hsa-miR-519a hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmidHMGB3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HMGB3
    Predesigned siRNA for gene silencing in human, mouse, rat HMGB3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HMGB3

    Clone
    Products:
         
    OriGene clones in human, mouse for HMGB3 (see all 7)
    OriGene ORF clones in mouse, rat for HMGB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HMGB3 (NM_005342)
    Sino Biological Human cDNA Clone for HMGB3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMGB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMGB3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HMGB3
    Browse ESI BIO Cell Lines and PureStem Progenitors for HMGB3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGB3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HMGB3_HUMAN, O15347: Nucleus (By similarity). Chromosome (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005694chromosome IEA--

    Find genes that share ontologies with HMGB3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HMGB3
    Interactions:

        Search GeneGlobe Interaction Network for HMGB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HMGB3 (O153473 ENSP000003593934) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    HMGA1ENSP000003082274STRING: ENSP00000308227
    SUPT16HENSP000002162974STRING: ENSP00000216297
    DEKENSP000003804144STRING: ENSP00000380414
    NUP93ENSP000003106684STRING: ENSP00000310668
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006310DNA recombination ISS--
    GO:0007275multicellular organismal development TAS9598312

    Find genes that share ontologies with HMGB3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HMGB3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HMGB3 gene: 
    NM_005342.2  

    Unigene Cluster for HMGB3:

    High mobility group box 3
    Hs.19114  [show with all ESTs]
    Unigene Representative Sequence: NM_005342
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419110 ENST00000325307(uc004fep.3 uc004feq.3 uc004fer.3)
    ENST00000455596 ENST00000430118 ENST00000448905
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HMGB3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HMGB3 (see all 95):
    hsa-miR-579 hsa-miR-3194-5p hsa-miR-106a hsa-miR-128 hsa-miR-3653 hsa-miR-30d hsa-miR-519a hsa-miR-759
    SwitchGear 3'UTR luciferase reporter plasmidHMGB3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HMGB3
    Predesigned siRNA for gene silencing in human, mouse, rat HMGB3
    Clone
    Products:
         
    OriGene clones in human, mouse for HMGB3 (see all 7)
    OriGene ORF clones in mouse, rat for HMGB3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HMGB3 (NM_005342)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMGB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMGB3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HMGB3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HMGB3
      QuantiTect SYBR Green Assays in human, mouse, rat HMGB3
      QuantiFast Probe-based Assays in human, mouse, rat HMGB3

    Additional mRNA sequence: 

    BC007608.1 BC010378.1 BC012370.1 BC037210.1 BC070482.1 L05085.1 Y10043.1 

    9 DOTS entries:

    DT.412897  DT.92028174  DT.100034210  DT.101971788  DT.100001260  DT.86842456  DT.121162941  DT.121284332 
    DT.92432782 

    Selected AceView cDNA sequences (see all 227):

    BU685222 AI089310 CB241676 AA313436 AA039903 BC037210 AI024032 AA211075 
    AA479648 CA945201 AI954539 BM800508 BE463637 AW473141 BX281081 AI420778 
    BQ023557 L05085 BM713715 BC070482 BI019857 CD366268 AW630122 BG256857 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for HMGB3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                    
    SP2:                                    


    ECgene alternative splicing isoforms for HMGB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HMGB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAGAAGAA
    HMGB3 Expression
    About this image


    HMGB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Placenta (Extraembryonic Tissues)
    HMGB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HMGB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.19114

    UniProtKB/Swiss-Prot: HMGB3_HUMAN, O15347
    Tissue specificity: Expressed predominantly in placenta

        Custom PCR Arrays for HMGB3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HMGB3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HMGB3
    QuantiTect SYBR Green Assays in human, mouse, rat HMGB3
    QuantiFast Probe-based Assays in human, mouse, rat HMGB3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HMGB3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hmgb35 high mobility group box 3   --   X (36.92 cM) 71555918 
    chicken
    (Gallus gallus)
    Aves HMGB31 high mobility group box 3 84.33(n)
    94.64(a)
      396232  NM_205295.1  NP_990626.2 
    lizard
    (Anolis carolinensis)
    Reptilia HMGB36
    high mobility group box 3
    83(a)
    1 ↔ 1
    GL343310.1(664891-672015)
    African clawed frog
    (Xenopus laevis)
    Amphibia hmgb3-prov2 high mobility group box 3 81.48(n)    BC044009.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmgb3b6
    hmgb3a6
    high-mobility group box 3a
    65(a)
    65(a)
    1 ↔ many
    1 ↔ many
    21(33085576-33095593) ENSDARG00000006408
    7(27039093-27044149) ENSDARG00000056725
    fruit fly
    (Drosophila melanogaster)
    Insecta Dsp16
    Dorsal switch protein 1
    24(a)
    1 → many
    X(16227645-16234657)
    worm
    (Caenorhabditis elegans)
    Secernentea hmg-1.16
    Protein HMG-1.1 (hmg-1.1) mRNA, complete cds
    51(a)
    1 → many
    II(14250695-14251448) WBGene00001971
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes IXR1(YKL032C)4 Protein that binds DNA containing intrastrand cross-links more   --   11(381858-380065) 853836  NP_012893.1 


    ENSEMBL Gene Tree for HMGB3 (if available)
    TreeFam Gene Tree for HMGB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HMGB3 gene
    HMGB42  HMGB12  HMGB22  
    14 SIMAP similar genes for HMGB3 using alignment to 4 protein entries:     HMGB3_HUMAN (see all proteins):
    DKFZp779G118    HMG1    HMGB2    HMGB1    HMGB1P1    SP100
    HMGB4    SOX26    SOX25    SMARCE1    SRY    HMG20B
    soxB    WUGSC

    Find genes that share paralogs with HMGB3           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for HMGB3 (see all 28)
    PGOHUM00000251257 PGOHUM00000242401 PGOHUM00000256736 PGOHUM00000247898 PGOHUM00000259139


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HMGB3 (see all 112)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1856094971,2
    --150149893(+) GGGACA/CTGGGT 1 -- us2k10--------
    rs344153471,2
    C--150149964(+) TTTTT-/T/T   
       T
    /TTT
    CGGAG
    2 -- us2k1 cds10--------
    rs1900327991,2
    --150150165(+) ATCTCA/GTGATC 1 -- us2k10--------
    rs1810876301,2
    --150150470(+) CTCATA/GAATAG 1 -- us2k10--------
    rs1859269441,2
    --150150651(+) TTGAAC/GTGGAG 1 -- us2k10--------
    rs1908824201,2
    --150150814(+) GGCTCC/TTATAC 1 -- us2k10--------
    rs1501102421,2
    --150151069(+) CAAATG/TCTCTG 1 -- us2k10--------
    rs1839629051,2
    --150151076(+) TCTGCG/TCTTGC 1 -- us2k10--------
    rs22937381,2
    C--150151301(+) CGCGTA/TTCTGT 1 -- us2k11Minor allele frequency- T:0.00NA 1
    rs2007948461,2
    --150151548(+) CCCGA-/GGGGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HMGB3 (150148982 - 150159248 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HMGB3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HMGB3
    DNA2.0 Custom Variant and Variant Library Synthesis for HMGB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 300193    OMIM disorders: --

    2 diseases for HMGB3:    
    About MalaCards
    microphthalmia, syndromic 13    terminal osseous dysplasia


    Find genes that share disorders with HMGB3           About GenesLikeMe


    Export disorders for HMGB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HMGB3 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with HMGB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Hmg4, a new member of the Hmg1/2 gene family. (PubMed id 9598312)1, 3 Vaccari T....Bianchi M.E. (Genomics 1998)
    4. Isolation of human and mouse HMG2a cDNAs: evidence for an HMG2a- specific 3' untranslated region. (PubMed id 9370291)1, 2 Wilke K.... Poustka A. (Gene 1997)
    5. Prognostic value of HMGB3 expression in patients with non-small cell lung cancer. (PubMed id 23609034)1 Song N....Zhang C.M. (Tumour Biol. 2013)
    6. Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition. (PubMed id 22241470)1 Tan E.J....Moustakas A. (J. Biol. Chem. 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Hmgb3 is regulated by microRNA-206 during muscle regeneration. (PubMed id 22912879)1 Maciotta S....Torrente Y. (PLoS ONE 2012)
    9. High mobility group-box 3 overexpression is associated with poor prognosis of resected gastric adenocarcinoma. (PubMed id 23326140)1 Tang H.R....Wu C.Y. (World J. Gastroenterol. 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3149 HGNC: 5004 AceView: HMGB3 Ensembl:ENSG00000029993 euGenes: HUgn3149
    ECgene: HMGB3 H-InvDB: HMGB3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HMGB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HMGB3 gene:
    Search GeneIP for patents involving HMGB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for HMGB3 (HMGB3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HMGB3   OriGene RNAi products in human, mouse, rat for HMGB3  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HMGB3  
     OriGene qSTAR qPCR primer pairs in human, mouse for HMGB3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HMGB3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HMGB3   OriGene Custom Protein Services for HMGB3  

     
     
     Block miRNA regulation of human, mouse, rat HMGB3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HMGB3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMGB3 Predesigned siRNA for gene silencing in human, mouse, rat HMGB3
     QuantiFast Probe-based Assays in human, mouse, rat HMGB3 QuantiTect SYBR Green Assays in human, mouse, rat HMGB3
     Custom PCR Arrays for HMGB3 Search Chromatin IP Primers for HMGB3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HMGB3  Search GeneGlobe Interaction Network for HMGB3
     Regulatory tfbs in HMGB3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HMGB3 GenScript cDNA clones with any tag delivered in your preferred vector for HMGB3
     GenScript Custom Assay Services for HMGB3 GenScript Custom overexpressing Cell Line Services for HMGB3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HMGB3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for HMGB3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HMGB3 antibodies
     HMGB3 proteins
     HMGB3 lysates
     Antibodies for HMGB3
     See all of Abcam's Antibodies, Kits and Proteins for HMGB3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for HMGB3
     Proteins for HMGB3
     Antibodies for HMGB3
     ELISAs for HMGB3
     CLIAs for HMGB3



     Browse ESI BIO Cell Lines and PureStem Progenitors for HMGB3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGB3
     SwitchGear 3'UTR luciferase reporter plasmids for HMGB3
     SwitchGear Promoter luciferase reporter plasmids for HMGB3
     ThermoFisher Antibodies for HMGB3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMGB3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HMGB3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HMGB3
     LSBio Antibodies in human, mouse, rat for HMGB3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for HMGB3
      Search eBioscience for proteins for HMGB3
      Search eBioscience for elisas for HMGB3
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HMGB3 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4