Aliases for HMGB3 Gene
External Ids for HMGB3 Gene
Previous HGNC Symbols for HMGB3 Gene
Previous GeneCards Identifiers for HMGB3 Gene
This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
GeneCards Summary for HMGB3 Gene
HMGB3 (High Mobility Group Box 3) is a Protein Coding gene. Diseases associated with HMGB3 include microphthalmia, syndromic 13 and terminal osseous dysplasia. GO annotations related to this gene include poly(A) RNA binding and double-stranded DNA binding. An important paralog of this gene is HMGB4.
UniProtKB/Swiss-Prot for HMGB3 Gene
Binds preferentially single-stranded DNA and unwinds double-stranded DNA.