Aliases for HMGB2 Gene
Aliases for HMGB2 Gene
External Ids for HMGB2 Gene
- HGNC: 5000
- Entrez Gene: 3148
- Ensembl: ENSG00000164104
- OMIM: 163906
- UniProtKB: P26583
Previous HGNC Symbols for HMGB2 Gene
- HMG2
Previous GeneCards Identifiers for HMGB2 Gene
- GC04M175172
- GC04M174790
- GC04M174948
- GC04M174627
- GC04M174489
- GC04M174252
- GC04M170000
Summaries for HMGB2 Gene
-
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]
GeneCards Summary for HMGB2 Gene
HMGB2 (High Mobility Group Box 2) is a Protein Coding gene. Diseases associated with HMGB2 include Rheumatoid Arthritis, Systemic Juvenile. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Ectoderm Differentiation. GO annotations related to this gene include poly(A) RNA binding and chromatin binding. An important paralog of this gene is HMGB1.
UniProtKB/Swiss-Prot for HMGB2 Gene
-
Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGB2 Gene
Genomics for HMGB2 Gene
Regulatory Elements for HMGB2 Gene
Enhancers for HMGB2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH04G173369 | 1.4 | ENCODE dbSUPER | 13.1 | -36.0 | -35980 | 4.2 | HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 | CEP44 HMGB2 ENSG00000248774 SCRG1 FBXO8 LOC105377540 LOC101928383 |
| GH04G173366 | 0.9 | Ensembl ENCODE | 13.6 | -32.5 | -32541 | 1.6 | JUN CEBPB JUNB DPF2 TBX21 FOSL1 ARID1B JUND SCRT2 HMBOX1 | HMGB2 ENSG00000248774 SCRG1 RNU6-1096P CEP44 FBXO8 SAP30 GC04P173358 |
| GH04G173374 | 0.4 | Ensembl | 13.1 | -39.0 | -38976 | 0.2 | ZBTB33 ZEB2 | HMGB2 ENSG00000248774 SCRG1 CEP44 FBXO8 LOC105377540 LOC101928383 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HMGB2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HMGB2 gene promoter:
Regulatory Element Products
Genomic Location for HMGB2 Gene
- Chromosome:
- 4
- Start:
- 173,331,376 bp from pter
- End:
- 173,335,125 bp from pter
- Size:
- 3,750 bases
- Orientation:
- Minus strand
Genomic View for HMGB2 Gene
Genes around HMGB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q34.1 by Ensembl
- 4q34.1 by Entrez Gene
- 4q34.1 by HGNC
HMGB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMGB2 Gene
Proteins for HMGB2 Gene
-
Protein details for HMGB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P26583-HMGB2_HUMAN
- Recommended name:
- High mobility group protein B2
- Protein Accession:
- P26583
- B2R4K8
- D3DP37
- Q5U072
Protein attributes for HMGB2 Gene
- Size:
- 209 amino acids
- Molecular mass:
- 24034 Da
- Quaternary structure:
-
- Interacts with POU2F2, POU2F1 and POU3F1 (By similarity). Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2 (By similarity). Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Directly interacts with SET (PubMed:11909973). Interacts with LEF1 (By similarity).
Protein Expression for HMGB2 Gene
Post-translational modifications for HMGB2 Gene
- Acetylation enhances nucleosome binding and chromation remodeling activity.
- Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB2 (HMGB2C23hC45hC106h), 2- disulfide HMGB2 (HMGB2C23-C45C106h) and 3- sulfonyl HMGB2 (HMGB2C23soC45soC106so).
- Ubiquitination at posLast=147147
- Modification sites at PhosphoSitePlus
Other Protein References for HMGB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for HMGB2 (HMGB2)
-
Custom Antibody ServicesOriGene Antibodies for HMGB2
- Novus Biologicals Antibodies for HMGB2
-
Cloud-Clone Corp. Antibodies for HMGB2
- Invitrogen Antibodies for HMGB2
- antibodies-online Antibodies for HMGB2: See all 79
- GeneTex HMGB2 antibody for HMGB2
-
Santa Cruz Biotechnology (SCBT) Antibodies for HMGB2
Protein Products
-
OriGene Purified Proteins for HMGB2
- Search Origene for MassSpec and Protein Over-expression Lysates for HMGB2
- Origene Custom Protein Services for HMGB2
- ProSpec Recombinant Proteins for HMGB2
-
Cloud-Clone Corp. Proteins for HMGB2
- antibodies-online Proteins for HMGB2: See all 21
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HMGB2
-
ProSci Proteins for HMGB2
Assay Products
- antibodies-online Kits for HMGB2: See all 9
No data available for DME Specific Peptides for HMGB2 Gene
Domains & Families for HMGB2 Gene
Gene Families for HMGB2 Gene
Protein Domains for HMGB2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HMGB2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P26583UniProtKB/Swiss-Prot:
HMGB2_HUMAN :- Both, HMG box 1 and HMG box 2, show antimicrobial activity.
- Belongs to the HMGB family.
- Domain:
-
- Both, HMG box 1 and HMG box 2, show antimicrobial activity.
- Family:
-
- Belongs to the HMGB family.
Function for HMGB2 Gene
Molecular function for HMGB2 Gene
- UniProtKB/Swiss-Prot Function:
- Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000400 | four-way junction DNA binding | ISS | -- |
| GO:0001158 | enhancer sequence-specific DNA binding | ISS | -- |
| GO:0003677 | DNA binding | IMP,IEA | 11909973 |
| GO:0003684 | damaged DNA binding | IDA | 8226934 |
| GO:0003690 | double-stranded DNA binding | ISS | -- |
Phenotypes for HMGB2 Gene
- MGI mutant phenotypes for HMGB2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HMGB2:
Animal Models for HMGB2 Gene
- MGI Knock Outs for HMGB2:
-
- Hmgb2 tm1Meb
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HMGB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGB2 gene
- Search ViGene Biosciences for HMGB2
CRISPR Products
-
OriGene CRISPR knockouts for HMGB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGB2
- GenScript: Design CRISPR guide RNA sequences for HMGB2
miRNA for HMGB2 Gene
- miRTarBase miRNAs that target HMGB2
-
- hsa-mir-181a-5p (MIRT025152)
- hsa-mir-33a-5p (MIRT028203)
- hsa-mir-24-3p (MIRT030580)
- hsa-mir-374a-5p (MIRT044016)
- hsa-mir-4452 (MIRT093569)
- hsa-mir-582-5p (MIRT309701)
- hsa-mir-1468-3p (MIRT356124)
- hsa-let-7a-2-3p (MIRT356148)
- hsa-let-7g-3p (MIRT356151)
- hsa-mir-4328 (MIRT371053)
- hsa-mir-23b-3p (MIRT438323)
- hsa-mir-23a-3p (MIRT438692)
- hsa-mir-218-5p (MIRT440494)
- hsa-mir-6514-3p (MIRT475590)
- hsa-mir-6894-3p (MIRT475591)
- hsa-mir-4325 (MIRT475592)
- hsa-mir-183-3p (MIRT475593)
- hsa-mir-127-5p (MIRT475594)
- hsa-mir-4766-3p (MIRT475595)
- hsa-mir-4487 (MIRT475596)
- hsa-mir-558 (MIRT475597)
- hsa-mir-3160-3p (MIRT475598)
- hsa-mir-6806-3p (MIRT475599)
- hsa-mir-3928-5p (MIRT475600)
- hsa-mir-4793-3p (MIRT475601)
- hsa-mir-4461 (MIRT475602)
- hsa-mir-548p (MIRT475603)
- hsa-mir-4724-5p (MIRT475604)
- hsa-mir-302f (MIRT475605)
- hsa-mir-5692a (MIRT475606)
- hsa-mir-130a-5p (MIRT475607)
- hsa-mir-23c (MIRT475608)
- hsa-mir-1277-5p (MIRT511516)
- hsa-mir-190a-3p (MIRT511517)
- hsa-mir-4789-5p (MIRT511518)
- hsa-mir-3941 (MIRT511519)
- hsa-mir-223-5p (MIRT511520)
- hsa-mir-511-3p (MIRT511521)
- hsa-mir-5011-5p (MIRT511522)
- hsa-mir-5580-3p (MIRT511523)
- hsa-mir-603 (MIRT511524)
- hsa-mir-362-3p (MIRT511525)
- hsa-mir-329-3p (MIRT511526)
- hsa-mir-8485 (MIRT511527)
- hsa-mir-544b (MIRT523159)
- hsa-mir-3622b-3p (MIRT523160)
- hsa-mir-3622a-3p (MIRT523161)
- hsa-mir-1228-3p (MIRT523162)
- hsa-mir-3924 (MIRT542934)
- hsa-mir-3119 (MIRT562210)
- hsa-mir-135b-5p (MIRT562211)
- hsa-mir-135a-5p (MIRT562212)
- hsa-mir-374c-3p (MIRT562213)
- hsa-mir-4796-3p (MIRT562214)
- hsa-mir-93-5p (MIRT562215)
- hsa-mir-526b-3p (MIRT562216)
- hsa-mir-519d-3p (MIRT562217)
- hsa-mir-20b-5p (MIRT562218)
- hsa-mir-20a-5p (MIRT562219)
- hsa-mir-17-5p (MIRT562220)
- hsa-mir-106b-5p (MIRT562221)
- hsa-mir-106a-5p (MIRT562222)
- hsa-mir-548ah-5p (MIRT562223)
- hsa-mir-3609 (MIRT562224)
- hsa-mir-6809-3p (MIRT562225)
- hsa-mir-6833-3p (MIRT562226)
- hsa-mir-4768-5p (MIRT562227)
- hsa-mir-4684-5p (MIRT562228)
- hsa-mir-187-5p (MIRT562229)
- hsa-mir-20a-3p (MIRT562230)
- hsa-mir-139-5p (MIRT562231)
- hsa-mir-153-5p (MIRT562232)
- hsa-mir-3919 (MIRT562233)
- hsa-mir-3123 (MIRT562234)
- hsa-mir-4797-5p (MIRT562235)
- hsa-mir-548l (MIRT562236)
- hsa-mir-548t-5p (MIRT562237)
- hsa-mir-548az-5p (MIRT562238)
- hsa-mir-548n (MIRT562239)
- hsa-mir-98-3p (MIRT567319)
- hsa-let-7f-1-3p (MIRT567320)
- hsa-let-7b-3p (MIRT567321)
- hsa-let-7a-3p (MIRT567322)
- hsa-mir-548c-3p (MIRT567323)
- hsa-mir-381-3p (MIRT567324)
- hsa-mir-300 (MIRT567325)
- hsa-mir-6869-5p (MIRT574707)
- hsa-mir-3613-3p (MIRT574708)
- hsa-mir-4668-3p (MIRT574709)
miRNA Products
- Search ViGene Biosciences for HMGB2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HMGB2
- Browse OriGene Inhibitory RNA Products For HMGB2
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGB2 gene
Clone Products
- Sino Biological Human cDNA Clone for HMGB2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HMGB2
-
ViGene Biosciences adenoviral particle packaged cDNA for HMGB2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HMGB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGB2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HMGB2 Gene
Localization for HMGB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HMGB2 Gene
- Nucleus. Chromosome. Cytoplasm. Secreted. Note=In basal state predominantly nuclear. {ECO:0000305}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISS | -- |
| GO:0000793 | condensed chromosome | IDA | 12925773 |
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IDA | 19811285 |
| GO:0005623 | cell | IDA | 15496585 |
Pathways & Interactions for HMGB2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis induced DNA fragmentation | ||
| 2 | CDK-mediated phosphorylation and removal of Cdc6 |
.31
|
|
| 3 | Chromatin Regulation / Acetylation | ||
| 4 | Granzyme Pathway | ||
| 5 | Apoptotic cleavage of cellular proteins | ||
Pathways by source for HMGB2 Gene
1 Cell Signaling Technology pathway for HMGB2 Gene
2 BioSystems pathways for HMGB2 Gene
5 Reactome pathways for HMGB2 Gene
2 Qiagen pathways for HMGB2 Gene
Interacting Proteins for HMGB2 Gene
Selected Interacting proteins:
ENSP00000296503
P26583-HMGB2_HUMAN
for HMGB2 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001938 | positive regulation of endothelial cell proliferation | IDA | 19811285 |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002437 | inflammatory response to antigenic stimulus | ISS | -- |
| GO:0006265 | DNA topological change | ISS | -- |
| GO:0006309 | apoptotic DNA fragmentation | TAS | -- |
No data available for SIGNOR curated interactions for HMGB2 Gene
Transcripts for HMGB2 Gene
mRNA/cDNA for HMGB2 Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (574) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HMGB2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HMGB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGB2
- GenScript: Design CRISPR guide RNA sequences for HMGB2
miRNA Products
- Search ViGene Biosciences for HMGB2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HMGB2
- Browse OriGene Inhibitory RNA Products For HMGB2
-
ViGene Biosciences ready-to-package AAV shRNAs for HMGB2 gene
Clone Products
- Sino Biological Human cDNA Clone for HMGB2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - |
Expression for HMGB2 Gene
mRNA differential expression in normal tissues according to GTEx for HMGB2 Gene
This gene is overexpressed in Whole Blood (x6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HMGB2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HMGB2 Gene:
HMGB2SOURCE GeneReport for Unigene cluster for HMGB2 Gene:
Hs.434953mRNA Expression by UniProt/SwissProt for HMGB2 Gene:
P26583-HMGB2_HUMAN
Tissue specificity:
Expressed in gastric and intestinal tissues (at protein level).
Evidence on tissue expression from TISSUES for HMGB2 Gene
- Liver(4.6)
- Skin(4.3)
- Nervous system(4.3)
- Bone marrow(2.8)
- Blood(2.4)
- Eye(2.4)
- Lymph node(2.3)
- Bone(2.2)
- Lung(2.2)
- Spleen(2.1)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for HMGB2
-
OriGene qPCR primer pairs for HMGB2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMGB2 Gene
Orthologs for HMGB2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HMGB2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
OneToMany | |
| HMGB2 35 34 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | HMGB2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HMGB2 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Hmgb2 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HMGB2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HMGB2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HMGB2 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | hmgb2a 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000005 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Dsp1 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | hmg-1.2 34 |
|
- Species where no ortholog for HMGB2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for HMGB2 Gene
(9) SIMAP similar genes for HMGB2 Gene using alignment to 2 proteins:
Pseudogenes.org Pseudogenes for HMGB2 Gene
- PGOHUM00000291595
- PGOHUM00000292229
- PGOHUM00000292680
- PGOHUM00000292706
- PGOHUM00000293059
- PGOHUM00000295163
- PGOHUM00000295671
- PGOHUM00000295950
- PGOHUM00000307800
- PGOHUM00000296624
- PGOHUM00000298437
- PGOHUM00000299076
- PGOHUM00000299463
- PGOHUM00000300267
- PGOHUM00000300641
- PGOHUM00000300738
- PGOHUM00000301022
- PGOHUM00000301434
- PGOHUM00000301554
- PGOHUM00000303268
- PGOHUM00000303350
- PGOHUM00000305253
Variants for HMGB2 Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000939790 | -- | 173,333,755(+) | TCCGC(C/T)TCCCG | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1002221210 | -- | 173,333,246(+) | ATACA(A/G)CAAAA | intron-variant, upstream-variant-2KB | |
| rs1002310680 | -- | 173,331,972(+) | GTACA(A/G)TTTTT | utr-variant-3-prime | |
| rs1002492482 | -- | 173,333,443(+) | AAGGC(C/T)CTCCT | intron-variant, upstream-variant-2KB | |
| rs1002897949 | -- | 173,334,437(+) | GGGCC(A/G)CATCC | nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime |
Residual Variation Intolerance Score:
44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.92;
19.01% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HMGB2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HMGB2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGB2 Gene
Disorders for HMGB2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rheumatoid arthritis, systemic juvenile |
|
Search HMGB2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HMGB2
No data available for UniProtKB/Swiss-Prot and Genatlas for HMGB2 Gene
Publications for HMGB2 Gene
- Sequence of human HMG2 cDNA. (PMID: 1754403) Majumdar A. … Seidman M.M. (Nucleic Acids Res. 1991) 2 3 4 64
- Antimicrobial activity of high-mobility-group box 2: a new function to a well-known protein. (PMID: 23877675) KA1chler R. … Wehkamp J. (Antimicrob. Agents Chemother. 2013) 3 4 64
- High-mobility group protein HMGB2 regulates human erythroid differentiation through trans-activation of GFI1B transcription. (PMID: 19965638) Laurent B. … DumAcnil D. (Blood 2010) 3 4 64
- HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha. (PMID: 19223331) Stros M. … PospA-silovA! S. (Nucleic Acids Res. 2009) 3 22 64
- Identification of potentially damaging amino acid substitutions leading to human male infertility. (PMID: 19369647) Kuzmin A. … Varmuza S. (Biol. Reprod. 2009) 3 46 64
Products for HMGB2 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for HMGB2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HMGB2
- Search Origene for MassSpec and Protein Over-expression Lysates for HMGB2
- Origene Custom Protein Services for HMGB2
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HMGB2
- Browse OriGene Inhibitory RNA Products For HMGB2
- OriGene qPCR primer pairs and template standards for HMGB2
- OriGene qPCR primer pairs for HMGB2
- OriGene CRISPR knockouts for HMGB2
- OriGene ORF clones in human for HMGB2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HMGB2
- GenScript: Next-day shipping cDNA ORF clone for HMGB2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HMGB2
- GenScript Custom Assay Services for HMGB2
- GenScript Custom overexpressing Cell Line Services for HMGB2
- GenScript: Design CRISPR guide RNA sequences for HMGB2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HMGB2
- Cell Signaling Technology (CST) Antibodies for HMGB2 (HMGB2)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for HMGB2
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HMGB2
- Novus Biologicals proteins and lysates for HMGB2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for HMGB2
- Cloud-Clone Corp. Antibodies for HMGB2
- Cloud-Clone Corp. Proteins for HMGB2
- Browse Assay Kits at Cloud-Clone Corp.
- antibodies-online Antibodies for HMGB2: See all 79
- antibodies-online Kits for HMGB2: See all 9
- antibodies-online Proteins for HMGB2: See all 21
- Search antibodies-online for peptides
- GeneTex HMGB2 antibody for HMGB2
- Search GeneTex for Proteins for HMGB2
- ViGene Biosciences adenoviral particle packaged cDNA for HMGB2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HMGB2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HMGB2 gene
- Search ViGene Biosciences for HMGB2
- Santa Cruz Biotechnology (SCBT) Antibodies for HMGB2
- Search Santa Cruz Biotechnology (SCBT) for HMGB2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HMGB2
- Search for HMGB2 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for HMGB2
- Horizon Cell Lines for HMGB2
- Cyagen custom Knockout/knockin (KOKI) mouse models for HMGB2
- VectorBuilder custom plasmid, inducible vectors for HMGB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HMGB2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HMGB2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer