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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HMGB2 Gene

protein-coding   GIFtS: 59
GCID: GC04M174252

high mobility group box 2

(Previous names: high-mobility group (nonhistone chromosomal) protein 2,...)
(Previous symbol: HMG2)
 Explore 18 diseases affiliated with
HMGB2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HMGB2    

Aliases
for HMGB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
High Mobility Group Box 21 2     High Mobility Group Protein 22 3
HMG21 2 3 5     HMG-22 3
High-Mobility Group (Nonhistone Chromosomal) Protein 21 2     High Mobility Group Protein B22
High-Mobility Group Box 21 2     

External Ids:    HGNC: 50001   Entrez Gene: 31482   Ensembl: ENSG000001641047   OMIM: 1639065   UniProtKB: P265833   

Export aliases for HMGB2 gene to outside databases

Previous GC identifers: GC04M175172 GC04M174790 GC04M174948 GC04M174627 GC04M174489 GC04M170000


Summaries
for HMGB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HMGB2:
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this
family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro
studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies
suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This
protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand
breaks repair and V(D)J recombination. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HMGB2_HUMAN, P26583
Function: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially
single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating
cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity)

Gene Wiki entry for HMGB2


Genomic Views
for HMGB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HMGB2 gene promoter:
         HFH-3   FOXI1   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): HMGB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HMGB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMGB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31   Ensembl cytogenetic band:  4q34.1   HGNC cytogenetic band: 4q31

HMGB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMGB2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M174252:  view genomic region     (about GC identifiers)

Start:
 174,252,527 bp from pter      End:
 174,256,276 bp from pter
Size:
 3,750 bases      Orientation:
 minus strand

Proteins
for HMGB2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HMGB2_HUMAN, P26583 (See protein sequence)
Recommended Name: High mobility group protein B2  
Size: 209 amino acids; 24034 Da
Subunit: Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or
HMGB2 (By similarity). Component of the SET complex, which also contains SET, ANP32A, APEX1 and NME1. Directly
interacts with SET
Subcellular location: Nucleus. Chromosome
Secondary accessions: B2R4K8 D3DP37 Q5U072

Explore the universe of human proteins at neXtProt for HMGB2: NX_P26583

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P26583

    • HMGB2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001124160.1  NP_001124161.1  NP_002120.1  

    ENSEMBL proteins: 
     ENSP00000296503   ENSP00000393448   ENSP00000404912   ENSP00000423001  
    Reactome Protein details: P26583
    Human Recombinant Protein Products: 
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    Novus Biologicals HMGB2 Proteins
    Novus Biologicals HMGB2 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for HMGB2
    Uscn Proteins for HMGB2

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000793condensed chromosome IDA12925773
    GO:0005615extracellular space IDA19811285
    GO:0005634nucleus IDA8339930
    GO:0005654nucleoplasm TAS--
    GO:0005730nucleolus ----


    HMGB2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HMGB2

    Protein Domains /
    Families
    for HMGB2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HMGB2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR009071 HMG_superfamily
     IPR017967 HMG_boxA_CS

    Graphical View of Domain Structure for InterPro Entry P26583

    ProtoNet protein and cluster: P26583

    1 Blocks protein family: IPB000135 High mobility group proteins HMG1 and HMG2

    UniProtKB/Swiss-Prot: HMGB2_HUMAN, P26583
    Similarity: Belongs to the HMGB family
    Similarity: Contains 2 HMG box DNA-binding domains


    Function
    for HMGB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HMGB2_HUMAN, P26583
    Function: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially
    single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating
    cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity)

    miRNA
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    hsa-miR-520d-5p hsa-miR-181c hsa-miR-300 hsa-miR-4328 hsa-miR-4272 hsa-let-7a-2* hsa-miR-421 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmid: HMGB2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IMP11909973
    GO:0003684damaged DNA binding IDA8226934
    GO:0003690double-stranded DNA binding ISS--
    GO:0003697single-stranded DNA binding ISS--
    GO:0003700sequence-specific DNA binding transcription factor activity IDA19223331


    HMGB2 for ontologies           About GeneDecksing


    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hmgb2):
     endocrine/exocrine gland  reproductive system 

    HMGB2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HMGB2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of DNA fragmentation factor
    		Activation of DNA fragmentation factor1.00
    		Granzyme-A Pathway0.32
    		Apoptosis induced DNA fragmentation1.00
    2Granzyme Pathway
    		Granzyme Pathway1.00
    3Chromatin Regulation / Acetylation
    		Chromatin Regulation / Acetylation1.00
    4Apoptotic cleavage of cellular proteins
    		Apoptotic execution phase0.73
    5Ubiquitinated Orc1 is degraded by the proteasome
    		Apoptosis0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HMGB2
        Granzyme-A Pathway
    Granzyme Pathway

    1 Cell Signaling Technology (CST) Pathway for HMGB2
        Chromatin Regulation / Acetylation

    4        Reactome Pathways for HMGB2
        Activation of DNA fragmentation factor
    Apoptosis induced DNA fragmentation
    Apoptotic execution phase
    Apoptosis



    HMGB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HMGB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for HMGB2 (P265832, 3 ENSP000002965034) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK1A1P487292, 3, ENSP000002617984MINT-16963 MINT-15018 I2D: score=4 STRING: ENSP00000261798
    SETQ011053, ENSP000003617774I2D: score=3 STRING: ENSP00000361777
    APEX1P276953, ENSP000002167144I2D: score=2 STRING: ENSP00000216714
    PGRP064013, ENSP000003251204I2D: score=2 STRING: ENSP00000325120
    PRKDCP785273, ENSP000003134204I2D: score=2 STRING: ENSP00000313420
    About this table

    Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001938positive regulation of endothelial cell proliferation IDA19811285
    GO:0006265DNA topological change ISS--
    GO:0006288base-excision repair, DNA ligation IDA9600082
    GO:0006309apoptotic DNA fragmentation TAS--
    GO:0006325chromatin organization NAS15504738


    HMGB2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HMGB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HMGB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HMGB2
    3 Novoseek chemical compound relationships for HMGB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cisplatin 33 9 1445361 (3), 8975778 (2), 10076573 (1), 8226934 (1)
    estrogen 0.701 1 9671457 (1)
    atp 0 1 8007973 (1)

    Search CenterWatch for drugs/clinical trials and news about HMGB2 

    Transcripts
    for HMGB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HMGB2 gene (3 alternative transcripts): 
    NM_001130688.1  NM_001130689.1  NM_002129.3  

    Unigene Cluster for HMGB2:

    High mobility group box 2
    Hs.434953  [show with all ESTs]
    Unigene Representative Sequence: BM555162
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296503(uc011ckc.1 uc003itb.2) ENST00000446922(uc003ita.3)
    ENST00000438704 ENST00000511316 ENST00000506267

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HMGB2
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate HMGB2 (see all 32):
    hsa-miR-520d-5p hsa-miR-181c hsa-miR-300 hsa-miR-4328 hsa-miR-4272 hsa-let-7a-2* hsa-miR-421 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmid: HMGB2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HMGB2 (see all 7)
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HMGB2
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK311864.1 BC000903.2 BC001063.2 BC100019.1 BT019782.1 BT019783.1 X62534.1 Z17240.1 

    24/27 DOTS entries (see all 27):

    DT.449733  DT.100672906  DT.100672915  DT.95172427  DT.100672916  DT.121238516  DT.97817430  DT.121238528 
    DT.423214  DT.95172429  DT.92324876  DT.92451695  DT.97817257  DT.100672905  DT.40133229  DT.92451701 
    DT.95172446  DT.102835225  DT.92040812  DT.92451703  DT.95358472  DT.100050472  DT.100672912  DT.92451690 

    24/574 AceView cDNA sequences (see all 574):

    CA436707 BM742354 AI065067 BQ574550 BC001063 BG942760 CR592990 BG402989 
    AW958534 AI745038 BM770625 BU195588 BM762154 BM463231 BQ231908 BE882796 
    AW167852 AA355862 BX421328 AA586616 CR590265 AA702683 AI954175 BM800082 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for HMGB2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c
    SP1:                                      -     -     -                                                     -                     
    SP2:                                      -     -     -     -     -                       -                 -                     
    SP3:                                            -     -                                                     -                     
    SP4:                                      -     -     -                                   -                 -                     
    SP5:                                      -     -     -                                                     -                     


    ECgene alternative splicing isoforms for HMGB2

    Expression
    for HMGB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HMGB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGCAAAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HMGB2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    BrainCerebral CortexBrain
    BrainHypothalamusBrain
    BrainThalamusBrain
    EyeRetinaEye
    Neural TubeDiencephalonNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HMGB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HMGB2

    SOURCE GeneReport for Unigene cluster: Hs.434953
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    In Situ
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    Orthologs
    for HMGB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HMGB2 gene from 9/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Hmgb21 , 5 high mobility group box 21, 5 90.11(n)1
    97.13(a)1    		   8 (29.90 cM)5
    971651  NM_008252.31  NP_032278.11 
     575118435 
    chicken
    (Gallus gallus)    		 Aves HMGB21 high mobility group box 2 83.9(n)
    90.82(a)    		   396482  NM_205486.1  NP_990817.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HMGB26
    		 --
    		 88(a)
    		 1 ↔ 1
    		 3(144519123-144523561)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AF549908.12   -- 77.55(n)    AF549908.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hmgb2a1 high-mobility group box 2a 75.16(n)
    75.96(a)    		   641484  NM_001037424.1  NP_001032501.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Dsp16
    		 Dorsal switch protein 1
    		 24(a)
    		 1 → many
    		 X(16227645-16234657)
    worm
    (Caenorhabditis elegans)    		 Secernentea hmg-1.26
    		 High mobility group protein 1.2
    		 31(a)
    		 possible ortholog
    		 III(6280332-6283068)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons NFD6
    		 FACT complex subunit SSRP1
    		 7(a)
    		 possible ortholog
    		 3(10784889-10788729)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 SSRP1-like FACT complex subunit, putative, express...
    SSRP1-like FACT complex subunit, putative, express...
    		 7(a)
    6(a)
    		 possible ortholog
    possible ortholog
    		 1(4496719-4503407)
    5(4965403-4971007)


    ENSEMBL Gene Tree for HMGB2 (if available)
    TreeFam Gene Tree for HMGB2 (if available) 

    Paralogs
    for HMGB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HMGB2 gene
    TOX2  TOX42  HMGB42  TOX32  HMGB32  HMGB12  TOX22  
    9 SIMAP similar genes for HMGB2 using alignment to 2 protein entries:     HMGB2_HUMAN (see all proteins):
    HMG1    HMGB1    HMGB1P1    DKFZp779G118    HMGB3    SP100
    HMGB4    SSRP1    WUGSC

    HMGB2 for paralogs           About GeneDecksing


    5/20 Pseudogenes.org Pseudogenes for HMGB2 (see all 20)
    PGOHUM00000239713 PGOHUM00000249958 PGOHUM00000248187 PGOHUM00000248208 PGOHUM00000246908


    Genomic Variants
    for HMGB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HMGB2
    DNA2.0 Custom Variant and Variant Library Synthesis for HMGB2

    Disorders / Diseases
    for HMGB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HMGB2 for disorders           About GeneDecksing

    OMIM gene information: 163906    OMIM disorders: --

    18 diseases for HMGB2:    About MalaCards
    complex v    juvenile rheumatoid arthritis    male infertility    rheumatoid arthritis
    ulcerative colitis    autoimmune hepatitis    arthritis    infertility
    medulloblastoma    hepatocellular carcinoma    osteoarthritis    hepatitis
    lung cancer    obesity    sarcoma    immunodeficiency
    carcinoma    malaria

    5 Novoseek disease relationships for HMGB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arthritis juvenile rheumatoid 36.3 2 2403401 (2)
    hepatitis autoimmune 35.5 2 10323891 (2)
    colitis ulcerative 31.5 3 9486411 (1), 9010268 (1), 10323891 (1)
    rheumatic diseases 24.9 3 9558172 (3)
    cancer 0 1 8975778 (1)

    Human Genome Epidemiology (HuGE) Navigator: HMGB2 (2 documents)

    Export disorders for HMGB2 gene to outside databases

    Publications
    for HMGB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HMGB2 gene, integrated from 9 sources (see all 114):
    (articles sorted by number of sources associating them with HMGB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence of human HMG2 cDNA. (PubMed id 1754403)1, 2, 3 Majumdar A....Seidman M.M. (1991)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. (PubMed id 11909973)1, 2 Fan Z.... Lieberman J. (2002)
    4. A human HMG2 cDNA with a novel 3'-untranslated region. (PubMed id 1475204)1, 2 Alexandre S.... Lee A.S. (1992)
    5. Structure of a gene coding for human HMG2 protein. (PubMed id 1551873)1, 2 Shirakawa H. and Yoshida M. (1992)
    6. The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures. (PubMed id 8339930)1, 9 Paull T.T....Johnson R.C. (1993)
    7. HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter. (PubMed id 11748232)1, 9 Stros M....Nakagawara A. (2002)
    8. High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells. (PubMed id 9671457)1, 9 Boonyaratanakornkit V....Edwards D.P. (1998)
    9. HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha. (PubMed id 19223331)1, 9 Stros M....PospA-silovA! S. (2009)
    10. High-mobility group protein 2 may be involved in the locus control region regulation of the beta-globin gene cluster. (PubMed id 12555809)1, 9 Lv X....Liang C.C. (2002)

    External Searches for HMGB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HMGB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3148 HGNC: 5000 AceView: HMGB2 Ensembl:ENSG00000164104 euGenes: HUgn3148
    ECgene: HMGB2 H-InvDB: HMGB2

    Other Databases showing HMGB2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HMGB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HMGB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HMGB2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for HMGB2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HMGB2 gene:
    Search GeneIP for patents involving HMGB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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