Aliases for HMGB1 Gene
External Ids for HMGB1 Gene
Previous HGNC Symbols for HMGB1 Gene
Previous GeneCards Identifiers for HMGB1 Gene
GeneCards Summary for HMGB1 Gene
HMGB1 (High Mobility Group Box 1) is a Protein Coding gene. Diseases associated with HMGB1 include staphylococcal toxic shock syndrome and endophthalmitis. Among its related pathways are amb2 Integrin signaling and RB in Cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and cytokine activity. An important paralog of this gene is HMGB4.
UniProtKB/Swiss-Prot for HMGB1 Gene
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).