Aliases for HMGA2 Gene
External Ids for HMGA2 Gene
Previous HGNC Symbols for HMGA2 Gene
Previous GeneCards Identifiers for HMGA2 Gene
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for HMGA2 Gene
HMGA2 (High Mobility Group AT-Hook 2) is a Protein Coding gene. Diseases associated with HMGA2 include Leiomyoma, Uterine, Somatic and 12Q14 Microdeletion Syndrome. Among its related pathways are Packaging Of Telomere Ends and Cellular Senescence. GO annotations related to this gene include enzyme binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding.
UniProtKB/Swiss-Prot for HMGA2 Gene
Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes.