Aliases for HMGA1 Gene
External Ids for HMGA1 Gene
Previous HGNC Symbols for HMGA1 Gene
Previous GeneCards Identifiers for HMGA1 Gene
This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]
GeneCards Summary for HMGA1 Gene
HMGA1 (High Mobility Group AT-Hook 1) is a Protein Coding gene. Diseases associated with HMGA1 include diabetes mellitus, noninsulin-dependent and pelvic lipomatosis. Among its related pathways are Regulation of Glucokinase by Glucokinase Regulatory Protein and HIV Life Cycle. GO annotations related to this gene include enzyme binding and ligand-dependent nuclear receptor transcription coactivator activity.
UniProtKB/Swiss-Prot for HMGA1 Gene
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.