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Aliases for HMGA1 Gene

Aliases for HMGA1 Gene

  • High Mobility Group AT-Hook 1 2 3
  • HMGIY 3 4 6
  • High-Mobility Group (Nonhistone Chromosomal) Protein Isoforms I And Y 2 3
  • High Mobility Group Protein A1 3 4
  • High Mobility Group Protein R 3 4
  • HMG-I(Y) 3 4
  • Nonhistone Chromosomal High-Mobility Group Protein HMG-I/HMG-Y 3
  • High Mobility Group Protein HMG-I/HMG-Y 3
  • High Mobility Group AT-Hook Protein 1 4
  • HMGA1A 3
  • HMG-R 3

External Ids for HMGA1 Gene

Previous Symbols for HMGA1 Gene

  • HMGIY

Summaries for HMGA1 Gene

Entrez Gene Summary for HMGA1 Gene

  • This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HMGA1 Gene

HMGA1 (High Mobility Group AT-Hook 1) is a Protein Coding gene. Diseases associated with HMGA1 include pelvic lipomatosis and ring chromosome 1. Among its related pathways are Disease and IL4-mediated signaling events. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and enzyme binding.

UniProtKB/Swiss-Prot for HMGA1 Gene

  • HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions

Gene Wiki entry for HMGA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGA1 Gene

Genomics for HMGA1 Gene

Genomic Location for HMGA1 Gene

Start:
34,236,800 bp from pter
End:
34,246,231 bp from pter
Size:
9,432 bases
Orientation:
Plus strand

Genomic View for HMGA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMGA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGA1 Gene

Regulatory Elements for HMGA1 Gene

Transcription factor binding sites by QIAGEN in the HMGA1 gene promoter:

Proteins for HMGA1 Gene

  • Protein details for HMGA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17096-HMGA1_HUMAN
    Recommended name:
    High mobility group protein HMG-I/HMG-Y
    Protein Accession:
    P17096
    Secondary Accessions:
    • P10910
    • Q5T6U9
    • Q9UKB0

    Protein attributes for HMGA1 Gene

    Size:
    107 amino acids
    Molecular mass:
    11676 Da
    Quaternary structure:
    • Interacts with HIPK2 (By similarity). Interacts with HIV-1 pre-integration complex.

    Three dimensional structures from OCA and Proteopedia for HMGA1 Gene

    Alternative splice isoforms for HMGA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HMGA1 Gene

Proteomics data for HMGA1 Gene at MOPED

Post-translational modifications for HMGA1 Gene

  • Constitutively phosphorylated on two or three sites. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation of HMG-I at Ser-36, Thr-53 and Thr-78 and of HMG-Y at Thr-42 and Thr-67 by HIPK2 modulates DNA-binding affinity.
  • HMG-Y is not methylated
  • Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys7 and Lys46

Other Protein References for HMGA1 Gene

No data available for DME Specific Peptides for HMGA1 Gene

Domains for HMGA1 Gene

Gene Families for HMGA1 Gene

HGNC:
  • HMG :High-mobility group / Canonical

UniProtKB/Swiss-Prot:

HMGA1_HUMAN
Domain:
  • Contains 3 A.T hook DNA-binding domains.:
    • P17096
Family:
  • Belongs to the HMGA family.:
    • P17096
genes like me logo Genes that share domains with HMGA1: view

Function for HMGA1 Gene

Molecular function for HMGA1 Gene

UniProtKB/Swiss-Prot Function: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions

Gene Ontology (GO) - Molecular Function for HMGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 10871404
GO:0003680 AT DNA binding TAS 10428834
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity IDA 19465398
GO:0005515 protein binding IPI 10428834
GO:0008134 transcription factor binding IDA 10428834
genes like me logo Genes that share ontologies with HMGA1: view
genes like me logo Genes that share phenotypes with HMGA1: view

Animal Models for HMGA1 Gene

MGI Knock Outs for HMGA1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HMGA1 Gene

Localization for HMGA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGA1 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMGA1 Gene COMPARTMENTS Subcellular localization image for HMGA1 gene
Compartment Confidence
nucleus 5
cytosol 4
endoplasmic reticulum 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HMGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16791210
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex TAS 10428834
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with HMGA1: view

Pathways for HMGA1 Gene

genes like me logo Genes that share pathways with HMGA1: view

Pathways by source for HMGA1 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for HMGA1 Gene
1 Qiagen pathway for HMGA1 Gene
1 Cell Signaling Technology pathway for HMGA1 Gene

Gene Ontology (GO) - Biological Process for HMGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000737 DNA catabolic process, endonucleolytic --
GO:0006268 DNA unwinding involved in DNA replication NAS 10428834
GO:0006284 base-excision repair IDA 19465398
GO:0006337 nucleosome disassembly TAS 10428834
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HMGA1: view

Compounds for HMGA1 Gene

(31) Novoseek inferred chemical compound relationships for HMGA1 Gene

Compound -log(P) Hits PubMed IDs
hmga 95.2 8
mevalonate 80.5 28
3-hydroxy-3-methylglutaryl-coa 79.1 21
sterol 69 19
27-hydroxycholesterol 63.7 4
genes like me logo Genes that share compounds with HMGA1: view

Transcripts for HMGA1 Gene

Unigene Clusters for HMGA1 Gene

High mobility group AT-hook 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMGA1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ·
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - - - -
SP13: - - - - - - - - -
SP14: - - - - - - - - - -
SP15: - - - - - - - -
SP16: - - - - -
SP17: - - - - - -
SP18: - - - - -
SP19: -
SP20: - - - - - -
SP21: - - - - - - - -
SP22:
SP23: - -
SP24: - - - - - - - -

ExUns: 13c · 13d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:

Relevant External Links for HMGA1 Gene

GeneLoc Exon Structure for
HMGA1
ECgene alternative splicing isoforms for
HMGA1

Expression for HMGA1 Gene

mRNA expression in normal human tissues for HMGA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HMGA1 Gene

This gene is overexpressed in Esophagus - Mucosa (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMGA1 Gene

SOURCE GeneReport for Unigene cluster for HMGA1 Gene Hs.518805

genes like me logo Genes that share expressions with HMGA1: view

Orthologs for HMGA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HMGA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMGA1 36
  • 100 (n)
  • 100 (a)
HMGA1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HMGA1 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HMGA1 36
  • 95.33 (n)
  • 100 (a)
HMGA1 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmga1 36
  • 91.9 (n)
  • 97.2 (a)
Hmga1 16
Hmga1 37
  • 97 (a)
OneToMany
Hmga1-rs1 37
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia HMGA1 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hmga1 36
  • 90.97 (n)
  • 96.26 (a)
chicken
(Gallus gallus)
Aves HMGA1 36
  • 74.51 (n)
  • 76.47 (a)
lizard
(Anolis carolinensis)
Reptilia HMGA1 37
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hmga1a 37
  • 51 (a)
OneToMany
hmga1b 37
  • 52 (a)
OneToMany
Species with no ortholog for HMGA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HMGA1 Gene

ENSEMBL:
Gene Tree for HMGA1 (if available)
TreeFam:
Gene Tree for HMGA1 (if available)

Paralogs for HMGA1 Gene

genes like me logo Genes that share paralogs with HMGA1: view

No data available for Paralogs for HMGA1 Gene

Variants for HMGA1 Gene

Sequence variations from dbSNP and Humsavar for HMGA1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs570312 -- 34,244,469(-) AATGG(G/T)AAGGG intron-variant
rs933164 -- 34,244,254(+) CTGGC(A/T)CGGGG intron-variant
rs1011905 -- 34,241,739(-) CCCAG(A/G)GAAGG intron-variant
rs1011906 -- 34,241,673(-) TAAGA(C/G)GGCAA intron-variant
rs1011907 -- 34,241,671(-) AGACG(C/G)CAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMGA1 Gene

Variant ID Type Subtype PubMed ID
nsv885781 CNV Loss 21882294
dgv6830n71 CNV Loss 21882294
nsv885784 CNV Loss 21882294
nsv823666 CNV Gain 20364138
esv24915 CNV Loss 19812545

Relevant External Links for HMGA1 Gene

HapMap Linkage Disequilibrium report
HMGA1
Human Gene Mutation Database (HGMD)
HMGA1

Disorders for HMGA1 Gene

(1) OMIM Diseases for HMGA1 Gene (600701)

UniProtKB/Swiss-Prot

HMGA1_HUMAN
  • Note=A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B.

(1) University of Copenhagen DISEASES for HMGA1 Gene

(35) Novoseek inferred disease relationships for HMGA1 Gene

Disease -log(P) Hits PubMed IDs
neoplastic transformation 75.8 16
lipoma 62.2 15
uterine leiomyoma 52.8 5
hamartoma 49.6 7
benign tumor 48.7 5

Relevant External Links for HMGA1

Genetic Association Database (GAD)
HMGA1
Human Genome Epidemiology (HuGE) Navigator
HMGA1
genes like me logo Genes that share disorders with HMGA1: view

Publications for HMGA1 Gene

  1. Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene. (PMID: 8414980) Friedmann M. … Reeves R. (Nucleic Acids Res. 1993) 2 3 4 23
  2. Tandem mass spectrometry for the examination of the posttranslational modifications of high-mobility group A1 proteins: symmetric and asymmetric dimethylation of Arg25 in HMGA1a protein. (PMID: 15835918) Zou Y. … Wang Y. (Biochemistry 2005) 3 4 23
  3. Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity. (PMID: 17960875) Zhang Q. … Wang Y. (J. Proteome Res. 2007) 3 4 23
  4. High mobility group AT-hook 1 (HMGA1) is an independent prognostic factor and novel therapeutic target in pancreatic adenocarcinoma. (PMID: 18473350) Liau S.S. … Whang E. (Cancer 2008) 3 23
  5. HAND1 gene expression is negatively regulated by the High Mobility Group A1 proteins and is drastically reduced in human thyroid carcinomas. (PMID: 19060921) Martinez Hoyos J. … Fusco A. (Oncogene 2009) 3 23

Products for HMGA1 Gene

  • Addgene plasmids for HMGA1

Sources for HMGA1 Gene

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