Aliases for HMGA1 Gene
Aliases for HMGA1 Gene
External Ids for HMGA1 Gene
- HGNC: 5010
- Entrez Gene: 3159
- Ensembl: ENSG00000137309
- OMIM: 600701
- UniProtKB: P17096
Previous HGNC Symbols for HMGA1 Gene
- HMGIY
Previous GeneCards Identifiers for HMGA1 Gene
- GC06P034206
- GC06P034251
- GC06P034312
- GC06P034205
- GC06P033927
- GC06P034209
- GC06P034445
- GC06P035768
- GC06P036298
- GC06P037284
- GC06P034920
- GC06P035503
- GC06P037624
- GC06P038313
- GC06P038953
Summaries for HMGA1 Gene
-
This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]
GeneCards Summary for HMGA1 Gene
HMGA1 (High Mobility Group AT-Hook 1) is a Protein Coding gene. Diseases associated with HMGA1 include Diabetes Mellitus, Noninsulin-Dependent and Ring Chromosome 1. Among its related pathways are Transport of the SLBP independent Mature mRNA and Validated targets of C-MYC transcriptional activation. GO annotations related to this gene include enzyme binding and ligand-dependent nuclear receptor transcription coactivator activity.
UniProtKB/Swiss-Prot for HMGA1 Gene
-
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGA1 Gene
Genomics for HMGA1 Gene
Regulatory Elements for HMGA1 Gene
Enhancers for HMGA1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HMGA1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HMGA1 gene promoter:
Regulatory Element Products
Genomic Location for HMGA1 Gene
- Chromosome:
- 6
- Start:
- 34,236,800 bp from pter
- End:
- 34,246,231 bp from pter
- Size:
- 9,432 bases
- Orientation:
- Plus strand
Genomic View for HMGA1 Gene
Genes around HMGA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.31 by Ensembl
- 6p21.31 by Entrez Gene
- 6p21.31 by HGNC
HMGA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMGA1 Gene
Proteins for HMGA1 Gene
-
Protein details for HMGA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17096-HMGA1_HUMAN
- Recommended name:
- High mobility group protein HMG-I/HMG-Y
- Protein Accession:
- P17096
- P10910
- Q5T6U9
- Q9UKB0
Protein attributes for HMGA1 Gene
- Size:
- 107 amino acids
- Molecular mass:
- 11676 Da
- Quaternary structure:
-
- Interacts with HIPK2 (By similarity). Interacts with HIV-1 pre-integration complex.
Three dimensional structures from OCA and Proteopedia for HMGA1 Gene
Protein Expression for HMGA1 Gene
Post-translational modifications for HMGA1 Gene
- Constitutively phosphorylated on two or three sites. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation of HMG-I at Ser-36, Thr-53 and Thr-78 and of HMG-Y at Thr-42 and Thr-67 by HIPK2 modulates DNA-binding affinity.
- HMG-Y is not methylated.
- Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for HMGA1 Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HMGA1
- R&D Systems Antibodies for HMGA1 (HMGA1B)
- Cell Signaling Technology (CST) Antibodies for HMGA1 (HMGA1)
-
Custom Antibody ServicesOriGene Antibodies for HMGA1
- Novus Biologicals Antibodies for HMGA1
-
Cloud-Clone Corp. Antibodies for HMGA1
- Invitrogen Antibodies for HMGA1
- antibodies-online Antibodies for HMGA1: See all 123
- GeneTex HMGA1 antibody for HMGA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HMGA1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for HMGA1
- Origene Custom Protein Services for HMGA1
- ProSpec Recombinant Proteins for HMGA1
-
Cloud-Clone Corp. Proteins for HMGA1
- antibodies-online Proteins for HMGA1: See all 24
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HMGA1
No data available for DME Specific Peptides for HMGA1 Gene
Domains & Families for HMGA1 Gene
Gene Families for HMGA1 Gene
Protein Domains for HMGA1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HMGA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P17096- Family:
-
- Belongs to the HMGA family.
Function for HMGA1 Gene
Molecular function for HMGA1 Gene
- UniProtKB/Swiss-Prot Function:
- HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001158 | enhancer sequence-specific DNA binding | IDA | 9253416 |
| GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding | ISS | -- |
| GO:0003677 | DNA binding | TAS | 10871404 |
| GO:0003680 | AT DNA binding | TAS | 10428834 |
| GO:0003682 | chromatin binding | ISS | -- |
Phenotypes for HMGA1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HMGA1 gene
- Search ViGene Biosciences for HMGA1
CRISPR Products
-
OriGene CRISPR knockouts for HMGA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGA1
- GenScript: Design CRISPR guide RNA sequences for HMGA1
miRNA for HMGA1 Gene
- miRTarBase miRNAs that target HMGA1
-
- hsa-mir-26a-5p (MIRT000110)
- hsa-mir-16-5p (MIRT000270)
- hsa-mir-125b-5p (MIRT000349)
- hsa-let-7b-5p (MIRT001625)
- hsa-let-7a-5p (MIRT003152)
- hsa-mir-124-3p (MIRT006562)
- hsa-mir-15a-5p (MIRT006801)
- hsa-mir-196a-5p (MIRT006802)
- hsa-mir-335-5p (MIRT018872)
- hsa-mir-98-5p (MIRT027852)
- hsa-mir-1301-3p (MIRT035976)
- hsa-mir-877-3p (MIRT037176)
- hsa-mir-877-5p (MIRT037370)
- hsa-mir-744-5p (MIRT037580)
- hsa-mir-296-3p (MIRT038421)
- hsa-mir-671-5p (MIRT039276)
- hsa-mir-18a-3p (MIRT040930)
- hsa-mir-324-3p (MIRT042853)
- hsa-mir-331-3p (MIRT043495)
- hsa-mir-222-3p (MIRT046655)
- hsa-mir-30c-5p (MIRT047920)
- hsa-mir-142-3p (MIRT053121)
- hsa-mir-185-3p (MIRT122798)
- hsa-mir-4675 (MIRT122808)
- hsa-mir-4741 (MIRT122811)
- hsa-mir-6805-5p (MIRT122816)
- hsa-mir-6846-5p (MIRT122818)
- hsa-mir-6848-5p (MIRT122819)
- hsa-mir-138-5p (MIRT168540)
- hsa-mir-1184 (MIRT168546)
- hsa-mir-1233-3p (MIRT168549)
- hsa-mir-3173-5p (MIRT168553)
- hsa-mir-4286 (MIRT168556)
- hsa-mir-4641 (MIRT168563)
- hsa-mir-6779-3p (MIRT168574)
- hsa-mir-6783-5p (MIRT168575)
- hsa-mir-6799-3p (MIRT168576)
- hsa-mir-6827-5p (MIRT168577)
- hsa-mir-6871-5p (MIRT168578)
- hsa-mir-7978 (MIRT168580)
- hsa-let-7c-5p (MIRT168581)
- hsa-let-7d-5p (MIRT168582)
- hsa-let-7e-5p (MIRT168583)
- hsa-let-7f-5p (MIRT168584)
- hsa-let-7g-5p (MIRT168587)
- hsa-let-7i-5p (MIRT168588)
- hsa-mir-15b-5p (MIRT168589)
- hsa-mir-195-5p (MIRT168591)
- hsa-mir-196b-5p (MIRT168592)
- hsa-mir-520a-5p (MIRT168595)
- hsa-mir-525-5p (MIRT168596)
- hsa-mir-4257 (MIRT168601)
- hsa-mir-4458 (MIRT168607)
- hsa-mir-4500 (MIRT168608)
- hsa-mir-6847-5p (MIRT168616)
- hsa-mir-185-5p (MIRT437482)
- hsa-mir-218-5p (MIRT440493)
- hsa-mir-3611 (MIRT475617)
- hsa-mir-3148 (MIRT475618)
- hsa-mir-6859-5p (MIRT475619)
- hsa-mir-3916 (MIRT475620)
- hsa-mir-4694-3p (MIRT475621)
- hsa-mir-3125 (MIRT475622)
- hsa-mir-758-3p (MIRT475623)
- hsa-mir-7108-5p (MIRT475624)
- hsa-mir-588 (MIRT475625)
- hsa-mir-4701-5p (MIRT475626)
- hsa-mir-4709-3p (MIRT475627)
- hsa-mir-6824-5p (MIRT475628)
- hsa-mir-6802-3p (MIRT475629)
- hsa-mir-663b (MIRT475630)
- hsa-mir-7974 (MIRT475631)
- hsa-mir-6809-5p (MIRT475632)
- hsa-mir-6133 (MIRT475633)
- hsa-mir-6130 (MIRT475634)
- hsa-mir-6129 (MIRT475635)
- hsa-mir-6127 (MIRT475636)
- hsa-mir-4510 (MIRT475637)
- hsa-mir-4419a (MIRT475638)
- hsa-mir-6862-3p (MIRT475639)
- hsa-mir-3681-3p (MIRT475640)
- hsa-mir-6784-3p (MIRT475641)
- hsa-mir-216a-3p (MIRT475642)
- hsa-mir-128-3p (MIRT475643)
- hsa-mir-6873-5p (MIRT475644)
- hsa-mir-3650 (MIRT536819)
- hsa-mir-920 (MIRT536821)
- hsa-mir-6726-5p (MIRT536822)
- hsa-mir-5591-5p (MIRT536823)
- hsa-mir-4300 (MIRT536824)
- hsa-mir-6090 (MIRT536825)
- hsa-mir-4659b-5p (MIRT657373)
- hsa-mir-4659a-5p (MIRT657374)
- hsa-mir-2355-5p (MIRT657375)
- hsa-mir-4749-3p (MIRT657376)
- hsa-mir-3189-5p (MIRT657377)
- hsa-mir-4758-3p (MIRT657378)
- hsa-mir-5699-5p (MIRT657379)
- hsa-mir-1236-3p (MIRT657380)
- hsa-mir-6872-3p (MIRT657381)
- hsa-mir-6769a-3p (MIRT657382)
miRNA Products
- Search ViGene Biosciences for HMGA1
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for HMGA1
- Browse OriGene Inhibitory RNA Products For HMGA1
- Search ViGene Biosciences for HMGA1
Clone Products
-
OriGene ORF clones in human for HMGA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HMGA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HMGA1
Cell Line Products
-
Horizon Cell Lines for HMGA1
-
ViGene Biosciences adenoviral particle packaged cDNA for HMGA1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HMGA1 gene
- Search ViGene Biosciences for HMGA1
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HMGA1 Gene
Localization for HMGA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HMGA1 Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| endoplasmic reticulum | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 16791210 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005667 | transcription factor complex | TAS | 10428834 |
| GO:0005694 | chromosome | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for HMGA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Life Cycle |
.92
.65
.45
|
|
| 2 | Autointegration results in viral DNA circles | ||
| 3 | Cellular Senescence | ||
| 4 | DNA Damage/Telomere Stress Induced Senescence | ||
| 5 | Transport of the SLBP independent Mature mRNA | ||
Pathways by source for HMGA1 Gene
1 Cell Signaling Technology pathway for HMGA1 Gene
5 BioSystems pathways for HMGA1 Gene
17 Reactome pathways for HMGA1 Gene
1 GeneGo (Thomson Reuters) pathway for HMGA1 Gene
1 Qiagen pathway for HMGA1 Gene
Interacting Proteins for HMGA1 Gene
Selected Interacting proteins:
ENSP00000308227
P17096-HMGA1_HUMAN
for HMGA1 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006268 | DNA unwinding involved in DNA replication | NAS | 10428834 |
| GO:0006284 | base-excision repair | IBA | -- |
| GO:0006337 | nucleosome disassembly | TAS | 10428834 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | TAS | 10871404 |
Transcripts for HMGA1 Gene
mRNA/cDNA for HMGA1 Gene
- (13) REFSEQ mRNAs :
- (23) Additional mRNA sequences :
- (2021) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HMGA1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HMGA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMGA1
- GenScript: Design CRISPR guide RNA sequences for HMGA1
miRNA Products
- Search ViGene Biosciences for HMGA1
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for HMGA1
- Browse OriGene Inhibitory RNA Products For HMGA1
- Search ViGene Biosciences for HMGA1
Clone Products
-
OriGene ORF clones in human for HMGA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HMGA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HMGA1
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP8: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
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| SP13: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP22: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP24: | - | - | - | - | - | - | - | - |
| ExUns: | 13c | · | 13d |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: | |||
| SP11: | |||
| SP12: | |||
| SP13: | |||
| SP14: | |||
| SP15: | |||
| SP16: | |||
| SP17: | |||
| SP18: | |||
| SP19: | |||
| SP20: | |||
| SP21: | |||
| SP22: | |||
| SP23: | |||
| SP24: |
Expression for HMGA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- S-shaped Body Cells S-shaped Body
- S-shaped Body
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Lymph (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for HMGA1 Gene
This gene is overexpressed in Esophagus - Mucosa (x4.6).
This gene is overexpressed in Peripheral blood mononuclear cells (9.6), Amniocyte (8.2), Tlymphocyte (7.7), Blymphocyte (6.7), and CD8 Tcells (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HMGA1 Gene
NURSA nuclear receptor signaling pathways regulating expression of HMGA1 Gene:
HMGA1SOURCE GeneReport for Unigene cluster for HMGA1 Gene:
Hs.518805Evidence on tissue expression from TISSUES for HMGA1 Gene
- Liver(4.9)
- Pancreas(4.9)
- Nervous system(4.9)
- Blood(4.8)
- Lung(4.8)
- Skin(4.8)
- Eye(4.7)
- Intestine(4.7)
- Muscle(4.7)
- Stomach(3.9)
- Kidney(3.2)
- Heart(2.9)
- Bone(2.8)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HMGA1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- nervous
- reproductive
- skeletal muscle
- skeleton
- urinary
Organs:
Head and neck:
- brain
- ear
- eye
- head
- jaw
- mandible
- maxilla
- mouth
- neck
- skull
Thorax:
- chest wall
- clavicle
- heart
- rib
- rib cage
- scapula
- sternum
Abdomen:
- kidney
- liver
- pancreas
Pelvis:
- ovary
- pelvis
- uterus
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- vertebrae
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for HMGA1
No data available for mRNA Expression by UniProt/SwissProt for HMGA1 Gene
Orthologs for HMGA1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HMGA1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HMGA1 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Hmga1 35 |
|
OneToMany | |
| Hmga1-rs1 34 16 35 |
|
||||
| dog (Canis familiaris) |
Mammalia | HMGA1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HMGA1 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Hmga1 34 |
|
||
| chicken (Gallus gallus) |
Aves | HMGA1 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HMGA1 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | hmga1b 35 |
|
OneToMany | |
| hmga1a 35 |
|
OneToMany |
- Species where no ortholog for HMGA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HMGA1 Gene
Pseudogenes.org Pseudogenes for HMGA1 Gene
No data available for Paralogs for HMGA1 Gene
Variants for HMGA1 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000055979 | -- | 34,236,150(+) | CTCCA(A/G)AACAC | upstream-variant-2KB | |
| rs1000097676 | -- | 34,239,965(+) | TCTGA(A/C)AAAGT | intron-variant, upstream-variant-2KB | |
| rs1000159077 | -- | 34,236,368(+) | CTGAC(-/A)ACCTG | upstream-variant-2KB | |
| rs1000396258 | -- | 34,246,423(+) | AAAAT(A/G)TATAC | downstream-variant-500B, utr-variant-3-prime | |
| rs1000947920 | -- | 34,236,759(+) | CGGCG(A/G)CGGCG | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10616n54 | CNV | gain | 21841781 |
| dgv10617n54 | CNV | gain | 21841781 |
| esv24915 | CNV | loss | 19812545 |
| nsv1137544 | CNV | deletion | 24896259 |
| nsv602863 | CNV | loss | 21841781 |
| nsv602865 | CNV | loss | 21841781 |
| nsv602866 | CNV | loss | 21841781 |
| nsv823666 | CNV | gain | 20364138 |
| nsv969388 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.81;
34.03% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HMGA1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGA1 Gene
Disorders for HMGA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diabetes mellitus, noninsulin-dependent |
|
|
| ring chromosome 1 |
|
|
| ectomesenchymoma |
|
|
| pelvic lipomatosis |
|
|
| malignant ectomesenchymoma |
|
|
Search HMGA1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
HMGA1_HUMAN- Note=A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B. {ECO:0000269 PubMed:11978964}.
Relevant External Links for HMGA1
No data available for Genatlas for HMGA1 Gene
Publications for HMGA1 Gene
- Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene. (PMID: 8414980) Friedmann M. … Reeves R. (Nucleic Acids Res. 1993) 2 3 4 22 64
- Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity. (PMID: 17960875) Zhang Q. … Wang Y. (J. Proteome Res. 2007) 3 4 22 64
- Serine ADP-ribosylation depends on HPF1. (PMID: 28190768) Bonfiglio J.J. … Matic I. (Mol. Cell 2017) 3 4 64
- Functional variants of the HMGA1 gene and type 2 diabetes mellitus. (PMID: 21364139) Chiefari E. … Brunetti A. (JAMA 2011) 3 46 64
- Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A. … Haiman C.A. (PLoS Genet. 2011) 3 46 64
Products for HMGA1 Gene
- R&D Systems Antibodies for HMGA1 (HMGA1B)
- Browse R&D Systems for Human Recombinant Proteins
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- Custom Antibody ServicesOriGene Antibodies for HMGA1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for HMGA1
- Origene Custom Protein Services for HMGA1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HMGA1
- Browse OriGene Inhibitory RNA Products For HMGA1
- OriGene qPCR primer pairs for HMGA1
- OriGene CRISPR knockouts for HMGA1
- OriGene ORF clones in human for HMGA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HMGA1
- GenScript: Next-day shipping cDNA ORF clone for HMGA1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HMGA1
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- GenScript Custom overexpressing Cell Line Services for HMGA1
- GenScript: Design CRISPR guide RNA sequences for HMGA1
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- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HMGA1
- Cell Signaling Technology (CST) Antibodies for HMGA1 (HMGA1)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for HMGA1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
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- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HMGA1
- Novus Biologicals proteins and lysates for HMGA1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ProSpec Recombinant Proteins for HMGA1
- Cloud-Clone Corp. Antibodies for HMGA1
- Cloud-Clone Corp. Proteins for HMGA1
- Cloud-Clone Corp Assay Kits for HMGA1
- Addgene plasmids for HMGA1
- antibodies-online Antibodies for HMGA1: See all 123
- antibodies-online Kits for HMGA1: See all 10
- antibodies-online Proteins for HMGA1: See all 24
- Search antibodies-online for peptides
- GeneTex HMGA1 antibody for HMGA1
- Search GeneTex for Proteins for HMGA1
- ViGene Biosciences adenoviral particle packaged cDNA for HMGA1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HMGA1 gene
- Search ViGene Biosciences for HMGA1
- Santa Cruz Biotechnology (SCBT) Antibodies for HMGA1
- Search Santa Cruz Biotechnology (SCBT) for HMGA1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HMGA1
- Horizon Cell Lines for HMGA1
- Cyagen custom Knockout/knockin (KOKI) mouse models for HMGA1
- VectorBuilder custom plasmid, inducible vectors for HMGA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HMGA1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HMGA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
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- (28) RNAdb
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- (32) CGAP SAGE
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- (37) SGD
- (38) FlyBase
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- (40) Pseudogene
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- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
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- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
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- (60) miRBase
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- (62) NCBI
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- (64) PubMed
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- (68) Abcam
- (69) Novus
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- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
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- (100) COMPARTMENTS
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