HMGA1 Gene
protein-coding GIFtS : 67 GCID: GC06 P035768
high mobility group AT-hook 1 high-mobility group (nonhistone chromosomal) protein isoforms... HMGIY )
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Aliasesfor HMGA1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Subcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 3 Aliases High Mobility Group AT-Hook 1 1 2 HMG-R2 HMGIY1 2 3 5 HMGA1A2 High-Mobility Group (Nonhistone Chromosomal) Protein Isoforms I And Y1 2 High Mobility Group Protein HMG-I/HMG-Y2 High Mobility Group Protein A12 3 Nonhistone Chromosomal High-Mobility Group Protein HMG-I/HMG-Y2 High Mobility Group Protein R2 3 High Mobility Group AT-Hook Protein 13 HMG-I(Y)2 3
External Ids: HGNC: 5010 1 Entrez Gene: 3159 2 Ensembl: ENSG00000137309 7 OMIM: 600701 5 UniProtKB: P17096 3 ORGUL members: NONCODE:n342882
Export aliases for HMGA1 gene to outside databases Previous GC identifers: GC06P034206 GC06P034251 GC06P034312 GC06P034205 GC06P033927 GC06P034209 GC06P034445
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Summariesfor HMGA1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for HMGA1 : This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: HMGA1_HUMAN, P17096 Function : HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggestedthat these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions Gene Wiki entry for HMGA1
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Genomic Viewsfor HMGA1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_007592.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the HMGA1 gene promoter:TBP Other transcription factors Search SABiosciences Chromatin IP Primers for HMGA1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6p21 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21 HMGA1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P035768: view genomic region
(about GC identifiers )
Start: 34,204,577 bp from pter End:
34,214,008 bp from pter
Size: 9,432 bases Orientation:
plus strand
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Proteinsfor HMGA1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: HMGA1_HUMAN, P17096 See
protein sequence )Recommended Name: Size : 107 amino acids; 11676 DaSubunit : Interacts with HIPK2 (By similarity). Interacts with HIV-1 pre-integration complexSubcellular location : Nucleus. ChromosomeMass spectrometry : Mass=11750; Mass_error=12; Method=MALDI; Range=2-107 (P17096-1); Note=With 1 acetyl and 2 phosphategroups; Source=PubMed:15835918;
Mass spectrometry : Mass=11828; Mass_error=12; Method=MALDI; Range=2-107 (P17096-1); Note=With 1 acetyl and 3 phosphategroups; Source=PubMed:15835918;
Mass spectrometry : Mass=11765; Mass_error=12; Method=MALDI; Range=2-107 (P17096-1); Note=With 1 acetyl, 1 methyl and 2phosphate groups; Source=PubMed:15835918;
Mass spectrometry : Mass=11844; Mass_error=12; Method=MALDI; Range=2-107 (P17096-1); Note=With 1 acetyl, 1 methyl and 3phosphate groups; Source=PubMed:15835918;
Mass spectrometry : Mass=11780; Mass_error=12; Method=MALDI; Range=2-107 (P17096-1); Note=With 1 acetyl, 2 methyl and 2phosphate groups; Source=PubMed:15835918;
Mass spectrometry : Mass=11858; Mass_error=12; Method=MALDI; Range=2-107 (P17096-1); Note=With 1 acetyl, 2 methyl and 3phosphate groups; Source=PubMed:15835918;
4 PDB 3D structures from :2EZD (3D) 2EZE (3D) 2EZF (3D) 2EZG (3D) Secondary accessions : P10910 Q5T6U9 Q9UKB0Alternative splicing : 3 isoforms : P17096-1 P17096-2 P17096-3 (Contains a phosphothreonine at position 42)Explore the universe of human proteins at neXtProt for HMGA1: NX_P17096 Post-translational modifications:
Constitutively phosphorylated on two or three sites. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoforms HMG-I and HMG-Y can be phosphorylated by HIPK2. Phosphorylation of HMG-I at Ser-36, Thr-53 and Thr-78 and of HMG-Y at Thr-42 and Thr-67 by HIPK2 modulates DNA-binding affinity1
HMG-Y is not methylated1 Methylation at Arg-58 is mutually exclusive with methylation at Arg-601 View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P17096 HMGA1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (6 alternative transcripts): NP_002122.1 NP_665906.1 NP_665908.1 NP_665909.1 NP_665910.1 NP_665912.1 ENSEMBL proteins: ENSP00000288245 ENSP00000318322 ENSP00000349871 ENSP00000378452 ENSP00000308227 ENSP00000385693 ENSP00000399888 ENSP00000363230 Reactome Protein details: P17096 Human Recombinant Protein Products: Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing HMGA1 Antibody Products: Assay Products for HMGA1:
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Protein
Domains /for HMGA1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P17096 ProtoNet protein and cluster: P17096
1 Blocks protein family : IPB000116 UniProtKB/Swiss-Prot: HMGA1_HUMAN, P17096 Similarity : Belongs to the HMGA familySimilarity : Contains 3 A.T hook DNA-binding domains
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Functionfor HMGA1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: HMGA1_HUMAN, P17096 Function : HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggestedthat these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 23 )human mouse rat see all 7 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 6 ): HMGA1 (NM_145903 ) Sino Biological Human cDNA Clone for HMGA1 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HMGA1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat HMGA1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGA1
Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12 ): About this table
About GeneDecksing 1 GenomeRNAi human phenotype for HMGA1 :Animal Models: Hmga1 tm1Afus Hmga1 tm1Brun Hmga1 tm1Cha Hmga1 tm2Afus 9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Hmga1) :About GeneDecksing
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Pathways & Interactionsfor HMGA1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/14 super-pathways (see all 14 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Integration of viral DNA into host genomic DNA 2 Plus-strand DNA synthesis 3 HIV Infection 4 Immune response_IL-2 activation and signaling pathway 5 Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
Pathway sources See GeneCards unified pathways Show all pathways 1 1 1 1 5 5/12 (see all 12 )About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HMGA1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/81 Interacting proteins for HMGA1 (P17096 1 , 2 , 3 ENSP00000308227 4 via UniProtKB, MINT, STRING , and/or I2D (see all 81 )Interactant Interaction Details GeneCard External ID(s) SP1 P08047 2 , 3 ENSP00000329357 4 MINT-49729 MINT-49730 MINT-49727 MINT-49728 I2D:
score=4 STRING: ENSP00000329357 CEBPB P17676 2 , 3 ENSP00000305422 4 MINT-49733 MINT-49732 MINT-49731 I2D:
score=6 STRING: ENSP00000305422 ORC2 Q13416 2 , 3 ENSP00000234296 4 MINT-7295311 I2D:
score=1 STRING: ENSP00000234296 PRMT6 Q96LA8 1 , 3 ENSP00000355145 4 EBI-746854,EBI-912440 I2D:
score=1 STRING: ENSP00000355145 ELF1 P32519 3 ENSP00000239882 4 I2D:
score=4 STRING: ENSP00000239882
About this table Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18 ): About this table
About GeneDecksing
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Drugs & Compoundsfor HMGA1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for HMGA1 10/31 Novoseek chemical compound relationships for HMGA1 gene (see all 31 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
hmga
95.2
8
12930952 (2), 14714251 (1), 19687300 (1), 18670638 (1) (see all 7 )
mevalonate
80.5
34
9237866 (4), 8970163 (2), 10506194 (2), 10698924 (2) (see all 22 )
3-hydroxy-3-methylglutaryl-coa
79.1
24
15686906 (2), 11349148 (1), 15949312 (1), 17516993 (1) (see all 20 )
sterol
69
23
1657912 (3), 12142284 (2), 7534808 (1), 20041128 (1) (see all 16 )
27-hydroxycholesterol
63.7
4
18024962 (2), 17516993 (1), 19401598 (1)
25-hydroxycholesterol
62.9
10
10333389 (2), 15136164 (2), 8057282 (1), 10506194 (1)
lovastatin
62.7
19
9869647 (2), 10506194 (2), 15755505 (2), 17213228 (2) (see all 10 )
ptms
62.2
7
17455969 (4), 16752910 (1), 17960875 (1), 15591590 (1)
dbds
61.4
3
11087394 (1), 11034995 (1)
lanosterol
58.6
10
10333389 (3), 7840615 (2), 1657912 (1), 18024962 (1)
HMGA1
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Transcriptsfor HMGA1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for HMGA1 gene (7 alternative transcripts): NM_002131.3 NM_145899.2 NM_145901.2 NM_145902.2 NM_145903.2 NM_145905.2 NM_145904.1 Unigene Clusters for HMGA1:
High mobility group AT-hook 1 Hs.518805 [show with all ESTs ] , Hs.703764 [show with all ESTs ] Unigene Representative Sequences: BC078664 , BG027840 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000347617 (uc003oiy.3 uc003ojd.3 ) ENST00000327014 ENST00000357318 (uc011dsp.2 )ENST00000478214 ENST00000395004 ENST00000311487 (uc003oit.3 uc011dso.2 uc003oiu.3 )ENST00000401473 (uc003oiv.3 uc003oiw.3 uc003oix.3 ) ENST00000447654 (uc003oiz.3 uc003oja.3 )ENST00000374116 (uc003ojc.3 ) Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 23 )human mouse rat see all 7 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 6 ): HMGA1 (NM_145903 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HMGA1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat HMGA1
Additional cDNA sequence: BC071863.1
24/80 DOTS entries (see all 80 ): DT.100701974 DT.99926692
DT.453256 DT.100844933 DT.97823072 DT.100701923 DT.85104951 DT.100701978 DT.99926682 DT.95156524 DT.100701929 DT.91833221 DT.100040080 DT.121373399 DT.100701910 DT.100701937 DT.100860391 DT.92051550 DT.100701917 DT.100701950 DT.100701931 DT.100701955 DT.100701954 DT.91728915 24/2021 AceView cDNA sequences (see all 2021 ):
AA443550 BM762544 BQ690867 BM761324 AW451959 BU151255 BQ949557 BQ653716 BM764106 AU130307 BM760693 BU845155 BQ690333 BU855297 BM557412 BM915342 AU124619 BE251221 AU139288 BM853334 CR595910 BE255828 CR620670 BU848667 GeneLoc Exon Structure 5/24 Alternative Splicing Database (ASD) splice patterns (SP) for HMGA1 (see all 24 ) About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · SP1 : - - - - - - - SP2 : - - - - - - - SP3 : - - - - - - - - SP4 : - - - - - - - - SP5 : - - - - - - -
ExUns: 13c · 13d SP1 : SP2 : SP3 : SP4 : SP5 :
ECgene alternative splicing isoforms for HMGA1
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Expression for HMGA1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section HMGA1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ATTTGTCCCA
About this image HMGA1 expression in embryonic tissues and stem cells About this table See HMGA1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for HMGA1 SOURCE GeneReport for Unigene clusters: Hs.518805 Hs.703764 SABiosciences Expression via Pathway-Focused PCR Arrays including HMGA1 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMGA1
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Orthologsfor HMGA1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for HMGA1 gene from 3/9 species (see all 9 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves HMGA11
high mobility group AT-hook 1
74.39(n) 72.63(a)
378795 NM_204369.1 NP_989700.1
lizard Reptilia HMGA16
--
67(a)
1 ↔ 1
4(121529454-121549715)
zebrafish Actinopterygii hmga1a1
high mobility group AT-hook 1a
58.61(n) 58.24(a)
406447 NM_213168.2 NP_998333.1
ENSEMBL Gene Tree for HMGA1 (if available)TreeFam Gene Tree for HMGA1 (if available)
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Paralogsfor HMGA1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for HMGA1 gene HMGA2 2 About GeneDecksing 5/7 Pseudogenes.org Pseudogenes for HMGA1 (see all 7 )PGOHUM00000238542 PGOHUM00000239577 PGOHUM00000248528 PGOHUM00000245962 PGOHUM00000243380
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Genomic Variantsfor HMGA1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 6 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for HMGA1 (34204577 - 34214008 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for HMGA1 1 CNV 69485 Human Gene Mutation Database (HGMD) : HMGA1 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor HMGA1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 600701
OMIM disorders : --UniProtKB/Swiss-Prot: HMGA1_HUMAN, P17096 Note=A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B 20/65 (see all 65 ): About MalaCards xeroderma pigmentosum, group a malignant peripheral nerve sheath tumor ring chromosomes atypical lipomatous tumor xeroderma pigmentosum pelvic lipomatosis ring chromosome 1 dermatofibrosarcoma protuberans lipomatosis dermatofibrosarcoma ganglioneuroma insulin resistance hpfh lipoma myxoma benign tumors pancreatic ductal adenocarcinoma pleomorphic adenoma synovial sarcoma gestational diabetes 1 disease from the University of Copenhagen DISEASES database for HMGA1 :Pelvic lipomatosis 10/35 Novoseek disease relationships for HMGA1 gene (see all 35 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
neoplastic transformation
75.8
21
11134344 (3), 10945639 (2), 15350136 (1), 19074878 (1) (see all 13 )
lipoma
62.2
20
9212729 (4), 10744071 (3), 12970064 (2), 9187132 (2) (see all 8 )
uterine leiomyoma
52.8
7
9989879 (2), 10472377 (1), 9824199 (1), 10744071 (1)
hamartoma
49.6
9
9060828 (3), 10744071 (3), 9824199 (1)
benign tumor
48.7
5
10347561 (1), 11672774 (1), 10744071 (1), 9495195 (1) (see all 5 )
tumors
43.6
99
19820691 (5), 11134344 (4), 10472377 (3), 14714251 (3) (see all 53 )
ganglioneuroma
38.8
1
15650238 (1)
thyroid carcinoma
35.1
6
19060921 (1), 7731681 (1), 16510570 (1)
cancer
34.7
54
17510387 (4), 17455969 (3), 19916743 (3), 20408779 (3) (see all 34 )
myxoma
32.5
1
11550285 (1)
Human Genome Epidemiology (HuGE) Navigator: HMGA1 (9 documents) Export disorders for HMGA1 gene to outside databases
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Publicationsfor HMGA1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for HMGA1 gene, integrated from 9 sources (see all 387 ):(articles sorted by number of sources associating them with HMGA1) Utopia : connect your pdf to the dynamic
Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene. (PubMed id 8414980) 1 , 2 , 3, 9(1993) Homeodomain-interacting protein kinase-2 (HIPK2) phosphorylates HMGA1a at Ser-35, Thr-52, and Thr-77 and modulates its DNA binding affinity. (PubMed id 17960875) 1 , 2 , 9(2007) Tandem mass spectrometry for the examination of the posttranslational modifications of high-mobility group A1 proteins: symmetric and asymmetric dimethylation of Arg25 in HMGA1a protein. (PubMed id 15835918) 1 , 2 , 9(2005) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 (2006) Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a. (PubMed id 16157300) 1 , 2 (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) During apoptosis of tumor cells HMGA1a protein undergoes methylation: identification of the modification site by mass spectrometry. (PubMed id 12653562) 1 , 2 (2003) HMGI/Y proteins: flexible regulators of transcription and chromatin structure. (PubMed id 11406267) 1 , 3(2001) Intragenic breakpoint within RAD51L1 in a t(6;14)(p21.3;q24) of a pulmonary chondroid hamartoma. (PubMed id 11978964) 1 , 2 (2001) Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor. (PubMed id 10428834) 1 , 2 (1999)
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About This Section Patent Information for HMGA1 gene: HMGA1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor HMGA1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for HMGA1 OriGene shRNA RFP for HMGA1 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for HMGA1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for HMGA1 OriGene 3'-UTR Clone for HMGA1 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for HMGA1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for HMGA1 OriGene Custom Protein Services for HMGA1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HMGA1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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