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Aliases for HMG20B Gene

Aliases for HMG20B Gene

  • High Mobility Group 20B 2 3 5
  • Structural DNA-Binding Protein BRAF35 3 4
  • HMG Domain-Containing Protein HMGX2 3 4
  • HMG Domain-Containing Protein 2 3 4
  • Sox-Like Transcriptional Factor 3 4
  • HMG Box-Containing Protein 20B 3 4
  • HMG Box Domain Containing 2 2 3
  • BRCA2-Associated Factor 35 3 4
  • High-Mobility Group 20B 2 3
  • SMARCE1-Related Protein 3 4
  • SMARCE1r 3 4
  • BRAF35 3 4
  • HMGXB2 3 4
  • HMGX2 3 4
  • SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily E, Member 1-Related 3
  • BRAF25 3
  • PP7706 3
  • Pp8857 3
  • SOXL 3

External Ids for HMG20B Gene

Previous GeneCards Identifiers for HMG20B Gene

  • GC19P003665
  • GC19P003642
  • GC19P003512
  • GC19P003523
  • GC19P003338

Summaries for HMG20B Gene

GeneCards Summary for HMG20B Gene

HMG20B (High Mobility Group 20B) is a Protein Coding gene. Among its related pathways are Chromatin organization and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include protein heterodimerization activity and chromatin binding. An important paralog of this gene is HMG20A.

UniProtKB/Swiss-Prot for HMG20B Gene

  • Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.

Gene Wiki entry for HMG20B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMG20B Gene

Genomics for HMG20B Gene

Regulatory Elements for HMG20B Gene

Enhancers for HMG20B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HMG20B on UCSC Golden Path with GeneCards custom track

Promoters for HMG20B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HMG20B on UCSC Golden Path with GeneCards custom track

Genomic Location for HMG20B Gene

Chromosome:
19
Start:
3,572,777 bp from pter
End:
3,579,088 bp from pter
Size:
6,312 bases
Orientation:
Plus strand

Genomic View for HMG20B Gene

Genes around HMG20B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMG20B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMG20B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMG20B Gene

Proteins for HMG20B Gene

  • Protein details for HMG20B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0W2-HM20B_HUMAN
    Recommended name:
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
    Protein Accession:
    Q9P0W2
    Secondary Accessions:
    • A6NMS5
    • D6W616
    • Q6IBP8
    • Q8NBD5
    • Q9HD21
    • Q9Y491
    • Q9Y4A2

    Protein attributes for HMG20B Gene

    Size:
    317 amino acids
    Molecular mass:
    35813 Da
    Quaternary structure:
    • Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with the BRCA2 tumor suppressor protein.
    SequenceCaution:
    • Sequence=AAC26860.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC26860.1; Type=Frameshift; Positions=223; Evidence={ECO:0000305}; Sequence=AAH21585.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HMG20B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HMG20B Gene

Proteomics data for HMG20B Gene at MOPED

Post-translational modifications for HMG20B Gene

  • Ubiquitination at Lys 208
  • Modification sites at PhosphoSitePlus

Other Protein References for HMG20B Gene

Antibody Products

No data available for DME Specific Peptides for HMG20B Gene

Domains & Families for HMG20B Gene

Gene Families for HMG20B Gene

Protein Domains for HMG20B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HMG20B Gene

Graphical View of Domain Structure for InterPro Entry

Q9P0W2

UniProtKB/Swiss-Prot:

HM20B_HUMAN :
  • Contains 1 HMG box DNA-binding domain.
Domain:
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with HMG20B: view

Function for HMG20B Gene

Molecular function for HMG20B Gene

UniProtKB/Swiss-Prot Function:
Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.

Phenotypes for HMG20B Gene

genes like me logo Genes that share phenotypes with HMG20B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HMG20B Gene

Localization for HMG20B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMG20B Gene

Nucleus. Chromosome. Note=Localized to condensed chromosomes in mitosis in conjunction with BRCA2.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMG20B Gene COMPARTMENTS Subcellular localization image for HMG20B gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for HMG20B Gene

Pathways & Interactions for HMG20B Gene

genes like me logo Genes that share pathways with HMG20B: view

Gene Ontology (GO) - Biological Process for HMG20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0016568 chromatin modification IEA --
GO:0016575 histone deacetylation TAS --
GO:0035914 skeletal muscle cell differentiation IEA --
GO:0045666 positive regulation of neuron differentiation IEA --
genes like me logo Genes that share ontologies with HMG20B: view

No data available for SIGNOR curated interactions for HMG20B Gene

Drugs & Compounds for HMG20B Gene

No Compound Related Data Available

Transcripts for HMG20B Gene

Unigene Clusters for HMG20B Gene

High mobility group 20B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMG20B Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^
SP1: - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - -
SP9: - -
SP10: - - -
SP11:
SP12: - -
SP13: -
SP14:

ExUns: 11a · 11b · 11c ^ 12a · 12b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for HMG20B Gene

GeneLoc Exon Structure for
HMG20B
ECgene alternative splicing isoforms for
HMG20B

Expression for HMG20B Gene

mRNA expression in normal human tissues for HMG20B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HMG20B Gene

This gene is overexpressed in Plasma (44.3), Placenta (11.4), and Peripheral blood mononuclear cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMG20B Gene



SOURCE GeneReport for Unigene cluster for HMG20B Gene Hs.406534

mRNA Expression by UniProt/SwissProt for HMG20B Gene

Q9P0W2-HM20B_HUMAN
Tissue specificity: Ubiquitously expressed in adult tissues.
genes like me logo Genes that share expression patterns with HMG20B: view

Protein tissue co-expression partners for HMG20B Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HMG20B Gene

Orthologs for HMG20B Gene

This gene was present in the common ancestor of animals.

Orthologs for HMG20B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia HMG20B 35
  • 86.73 (n)
  • 89.49 (a)
HMG20B 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmg20b 35
  • 85.49 (n)
  • 93.69 (a)
Hmg20b 16
Hmg20b 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hmg20b 35
  • 86.54 (n)
  • 93.69 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 58 (a)
OneToMany
HMG20B 36
  • 96 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia HMG20B 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HMG20B 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HMG20B 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves HMG20B 35
  • 81.96 (n)
  • 84.25 (a)
HMG20B 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hmg20b 35
  • 66.55 (n)
  • 76.69 (a)
MGC75938 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68625 35
zebrafish
(Danio rerio)
Actinopterygii hmg20b 35
  • 62.5 (n)
  • 63.19 (a)
wufc85b02 35
hmg20b 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9418 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hmg-20 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for HMG20B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HMG20B Gene

ENSEMBL:
Gene Tree for HMG20B (if available)
TreeFam:
Gene Tree for HMG20B (if available)

Paralogs for HMG20B Gene

Paralogs for HMG20B Gene

genes like me logo Genes that share paralogs with HMG20B: view

Variants for HMG20B Gene

Sequence variations from dbSNP and Humsavar for HMG20B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12980313 -- 3,571,208(+) cctca(A/G)cctcc upstream-variant-2KB
rs939209 -- 3,578,655(-) TTTTA(A/G)GGGGG utr-variant-3-prime
rs71166913 -- 3,575,959(+) AAAAA(-/A)GAAAA intron-variant
rs17849851 -- 3,577,100(+) CTGCC(A/G)GTGCC reference, synonymous-codon
rs1476786 -- 3,573,504(+) CTCGG(C/T)CTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMG20B Gene

Variant ID Type Subtype PubMed ID
nsv910722 CNV Loss 21882294
nsv910723 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
dgv3652n71 CNV Loss 21882294
dgv3655n71 CNV Loss 21882294
dgv3656n71 CNV Loss 21882294
dgv3657n71 CNV Loss 21882294
nsv910748 CNV Loss 21882294
nsv833713 CNV Loss 17160897
dgv3658n71 CNV Loss 21882294
nsv910752 CNV Loss 21882294
dgv3659n71 CNV Loss 21882294
dgv3660n71 CNV Loss 21882294

Variation tolerance for HMG20B Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HMG20B Gene

HapMap Linkage Disequilibrium report
HMG20B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMG20B Gene

Disorders for HMG20B Gene

Relevant External Links for HMG20B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HMG20B

No disorders were found for HMG20B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMG20B Gene

Publications for HMG20B Gene

  1. HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression. (PMID: 10773667) Sumoy L. … Peral B. (Cytogenet. Cell Genet. 2000) 2 3 4 67
  2. Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35. (PMID: 12809554) Lee Y.M. … Kim W. (Biochem. J. 2003) 3 23
  3. A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression. (PMID: 11207365) Marmorstein L.Y. … Shiekhattar R. (Cell 2001) 3 23
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for HMG20B Gene

Sources for HMG20B Gene

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