Aliases for HMG20B Gene
Aliases for HMG20B Gene
- High Mobility Group 20B 2 3 5
- Structural DNA-Binding Protein BRAF35 3 4
- HMG Domain-Containing Protein HMGX2 3 4
- HMG Domain-Containing Protein 2 3 4
- Sox-Like Transcriptional Factor 3 4
- HMG Box-Containing Protein 20B 3 4
- HMG Box Domain Containing 2 2 3
- BRCA2-Associated Factor 35 3 4
- SMARCE1-Related Protein 3 4
- SMARCE1r 3 4
- BRAF35 3 4
External Ids for HMG20B Gene
- HGNC: 5002
- Entrez Gene: 10362
- Ensembl: ENSG00000064961
- OMIM: 605535
- UniProtKB: Q9P0W2
Previous GeneCards Identifiers for HMG20B Gene
- GC19P003665
- GC19P003642
- GC19P003512
- GC19P003523
- GC19P003338
Summaries for HMG20B Gene
GeneCards Summary for HMG20B Gene
HMG20B (High Mobility Group 20B) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include protein heterodimerization activity and chromatin binding. An important paralog of this gene is HMG20A.
UniProtKB/Swiss-Prot for HMG20B Gene
-
Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMG20B Gene
Genomics for HMG20B Gene
Regulatory Elements for HMG20B Gene
Enhancers for HMG20B Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH19G003570 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 8.9 | +1.9 | 1851 | 8.0 | HDGF FOXA2 PKNOX1 ARNT AGO1 ZFP64 SIN3A ARID4B ZNF2 ZNF143 | MFSD12 HMG20B GIPC3 ENSG00000267980 |
| GH19G003568 | 1.4 | Ensembl ENCODE dbSUPER | 0.7 | -3.8 | -3806 | 0.7 | ATF1 BRCA1 ZNF766 ELK1 DEK NCOA1 ZNF592 CREB3 MBD2 STAT3 | TBXA2R CACTIN-AS1 ENSG00000266959 HMG20B |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HMG20B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HMG20B Gene
- Chromosome:
- 19
- Start:
- 3,572,777 bp from pter
- End:
- 3,579,088 bp from pter
- Size:
- 6,312 bases
- Orientation:
- Plus strand
Genomic View for HMG20B Gene
Genes around HMG20B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.3 by Ensembl
- 19p13.3 by Entrez Gene
- 19p13.3 by HGNC
HMG20B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMG20B Gene
Proteins for HMG20B Gene
-
Protein details for HMG20B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P0W2-HM20B_HUMAN
- Recommended name:
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
- Protein Accession:
- Q9P0W2
- A6NMS5
- D6W616
- Q6IBP8
- Q8NBD5
- Q9HD21
- Q9Y491
- Q9Y4A2
Protein attributes for HMG20B Gene
- Size:
- 317 amino acids
- Molecular mass:
- 35813 Da
- Quaternary structure:
-
- Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with the BRCA2 tumor suppressor protein.
- SequenceCaution:
-
- Sequence=AAC26860.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC26860.1; Type=Frameshift; Positions=223; Evidence={ECO:0000305}; Sequence=AAH21585.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for HMG20B Gene
Post-translational modifications for HMG20B Gene
Other Protein References for HMG20B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HMG20B
-
Custom Antibody ServicesOriGene Antibodies for HMG20B
- Novus Biologicals Antibodies for HMG20B
-
Cloud-Clone Corp. Antibodies for HMG20B
- Invitrogen Antibodies for HMG20B
- antibodies-online Antibodies for HMG20B: See all 70
- GeneTex HMG20B antibody for HMG20B
-
Santa Cruz Biotechnology (SCBT) Antibodies for HMG20B
Protein Products
-
OriGene Purified Proteins for HMG20B
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- Origene Custom Protein Services for HMG20B
-
Cloud-Clone Corp. Proteins for HMG20B
- antibodies-online Proteins for HMG20B: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HMG20B
Assay Products
No data available for DME Specific Peptides for HMG20B Gene
Domains & Families for HMG20B Gene
Gene Families for HMG20B Gene
Protein Domains for HMG20B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HMG20B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HMG20B Gene
Function for HMG20B Gene
Molecular function for HMG20B Gene
- UniProtKB/Swiss-Prot Function:
- Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0004407 | histone deacetylase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 21399666 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for HMG20B Gene
- GenomeRNAi human phenotypes for HMG20B:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HMG20B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HMG20B gene
- Search ViGene Biosciences for HMG20B
CRISPR Products
-
OriGene CRISPR knockouts for HMG20B
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMG20B
- GenScript: Design CRISPR guide RNA sequences for HMG20B
miRNA Products
- Search ViGene Biosciences for HMG20B
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HMG20B
- Browse OriGene Inhibitory RNA Products For HMG20B
-
ViGene Biosciences ready-to-package AAV shRNAs for HMG20B gene
Clone Products
-
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Cell Line Products
-
Horizon Cell Lines for HMG20B
-
ViGene Biosciences adenoviral particle packaged cDNA for HMG20B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HMG20B gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HMG20B Gene
Localization for HMG20B Gene
Subcellular locations from UniProtKB/Swiss-Prot for HMG20B Gene
- Nucleus. Chromosome. Note=Localized to condensed chromosomes in mitosis in conjunction with BRCA2.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS,IDA | -- |
| GO:0005694 | chromosome | IEA | -- |
| GO:0016604 | nuclear body | IDA | -- |
Pathways & Interactions for HMG20B Gene
Pathways by source for HMG20B Gene
5 Reactome pathways for HMG20B Gene
Interacting Proteins for HMG20B Gene
Selected Interacting proteins:
Q9P0W2-HM20B_HUMAN
ENSP00000328269
for HMG20B Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007596 | blood coagulation | TAS | -- |
| GO:0016569 | covalent chromatin modification | IEA | -- |
No data available for SIGNOR curated interactions for HMG20B Gene
Transcripts for HMG20B Gene
mRNA/cDNA for HMG20B Gene
- (2) REFSEQ mRNAs :
- (22) Additional mRNA sequences :
- (490) Selected AceView cDNA sequences:
- (16) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HMG20B Gene
CRISPR Products
-
OriGene CRISPR knockouts for HMG20B
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMG20B
- GenScript: Design CRISPR guide RNA sequences for HMG20B
miRNA Products
- Search ViGene Biosciences for HMG20B
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HMG20B
- Browse OriGene Inhibitory RNA Products For HMG20B
-
ViGene Biosciences ready-to-package AAV shRNAs for HMG20B gene
Clone Products
-
OriGene ORF clones in human for HMG20B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: | |||||||||
| SP9: | - | ||||||||
| SP10: | |||||||||
| SP11: | |||||||||
| SP12: | |||||||||
| SP13: | |||||||||
| SP14: |
Expression for HMG20B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Limb (Muscoskeletal System)
- Limb Bud Mesenchyme Cells Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
- Heart (Cardiovascular System)
- Eye (Sensory Organs)
This gene is overexpressed in Plasma (44.3), Placenta (11.4), and Peripheral blood mononuclear cells (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HMG20B Gene
NURSA nuclear receptor signaling pathways regulating expression of HMG20B Gene:
HMG20BSOURCE GeneReport for Unigene cluster for HMG20B Gene:
Hs.406534mRNA Expression by UniProt/SwissProt for HMG20B Gene:
Q9P0W2-HM20B_HUMAN
Tissue specificity:
Ubiquitously expressed in adult tissues.
Evidence on tissue expression from TISSUES for HMG20B Gene
- Skin(4.8)
- Nervous system(4.5)
- Heart(4.2)
- Pancreas(4.2)
- Eye(3)
- Lung(3)
Primer Products
-
OriGene qPCR primer pairs for HMG20B
-
OriGene qPCR primer pairs and template standards for HMG20B
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMG20B Gene
Orthologs for HMG20B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | HMG20B 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| chimpanzee (Pan troglodytes) |
Mammalia | HMG20B 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HMG20B 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | HMG20B 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hmg20b 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hmg20b 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HMG20B 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HMG20B 34 35 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hmg20b 34 |
|
||
| MGC75938 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68625 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hmg20b 34 35 |
|
||
| wufc85b02 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9418 35 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | hmg-20 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HMG20B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HMG20B Gene
(9) SIMAP similar genes for HMG20B Gene using alignment to 8 proteins:
Variants for HMG20B Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000181581 | -- | 3,576,751(+) | GCGCA(A/C)GCTGT | intron-variant | |
| rs1000213489 | -- | 3,574,350(+) | CCAGG(-/C)CCCCC | intron-variant | |
| rs1001049857 | -- | 3,572,445(+) | ATACA(C/T)AGGAA | upstream-variant-2KB | |
| rs1001393431 | -- | 3,571,085(+) | GGCTG(-/ATA)ATATT | upstream-variant-2KB | |
| rs1001437146 | -- | 3,572,623(+) | TCTTG(C/T)CTTCA | upstream-variant-2KB |
Residual Variation Intolerance Score:
72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.79;
16.60% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HMG20B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HMG20B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMG20B Gene
Disorders for HMG20B Gene
Relevant External Links for HMG20B
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HMG20B
No disorders were found for HMG20B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMG20B Gene
Publications for HMG20B Gene
- A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression. (PMID: 11207365) Marmorstein L.Y. … Shiekhattar R. (Cell 2001) 3 4 22 64
- HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression. (PMID: 10773667) Sumoy L. … Peral B. (Cytogenet. Cell Genet. 2000) 2 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for HMG20B Gene
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- GeneTex HMG20B antibody for HMG20B
- Search GeneTex for Proteins for HMG20B
- ViGene Biosciences adenoviral particle packaged cDNA for HMG20B gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for HMG20B
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- VectorBuilder custom plasmid, inducible vectors for HMG20B
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HMG20B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
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