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Aliases for HMG20B Gene

Aliases for HMG20B Gene

  • High Mobility Group 20B 2 3 5
  • Structural DNA-Binding Protein BRAF35 3 4
  • HMG Domain-Containing Protein HMGX2 3 4
  • HMG Domain-Containing Protein 2 3 4
  • Sox-Like Transcriptional Factor 3 4
  • HMG Box-Containing Protein 20B 3 4
  • HMG Box Domain Containing 2 2 3
  • BRCA2-Associated Factor 35 3 4
  • SMARCE1-Related Protein 3 4
  • SMARCE1r 3 4
  • BRAF35 3 4
  • HMGXB2 3 4
  • HMGX2 3 4
  • SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily E, Member 1-Related 3
  • SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily E Member 1-Related 3
  • High-Mobility Group 20B 2
  • BRAF25 3
  • PP7706 3
  • Pp8857 3
  • SOXL 3

External Ids for HMG20B Gene

Previous GeneCards Identifiers for HMG20B Gene

  • GC19P003665
  • GC19P003642
  • GC19P003512
  • GC19P003523
  • GC19P003338

Summaries for HMG20B Gene

GeneCards Summary for HMG20B Gene

HMG20B (High Mobility Group 20B) is a Protein Coding gene. Among its related pathways are Factors involved in megakaryocyte development and platelet production and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include protein heterodimerization activity and chromatin binding. An important paralog of this gene is HMG20A.

UniProtKB/Swiss-Prot for HMG20B Gene

  • Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.

Gene Wiki entry for HMG20B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMG20B Gene

Genomics for HMG20B Gene

Regulatory Elements for HMG20B Gene

Enhancers for HMG20B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F003570 1.4 FANTOM5 ENCODE 8.9 +1.4 1359 7.0 HDGF PKNOX1 ZFP64 SIN3A ARID4B ZNF2 ZNF143 FOS KLF13 ZNF263 MFSD12 HMG20B ENSG00000267980 GIPC3
GH19F003568 1.2 Ensembl ENCODE 0.8 -3.8 -3812 0.7 TBP HDAC1 ATF1 INSM2 KLF17 BRCA1 ZNF766 RCOR1 CREM EGR2 TBXA2R CACTIN-AS1 ENSG00000266959 HMG20B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HMG20B on UCSC Golden Path with GeneCards custom track

Promoters for HMG20B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000342091 523 2201 HDGF PKNOX1 SIN3A ARID4B ZNF2 ZNF143 FOS KLF13 ZNF263 SP3

Genomic Location for HMG20B Gene

Chromosome:
19
Start:
3,572,777 bp from pter
End:
3,579,088 bp from pter
Size:
6,312 bases
Orientation:
Plus strand

Genomic View for HMG20B Gene

Genes around HMG20B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMG20B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMG20B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMG20B Gene

Proteins for HMG20B Gene

  • Protein details for HMG20B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0W2-HM20B_HUMAN
    Recommended name:
    SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related
    Protein Accession:
    Q9P0W2
    Secondary Accessions:
    • A6NMS5
    • D6W616
    • Q6IBP8
    • Q8NBD5
    • Q9HD21
    • Q9Y491
    • Q9Y4A2

    Protein attributes for HMG20B Gene

    Size:
    317 amino acids
    Molecular mass:
    35813 Da
    Quaternary structure:
    • Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Interacts with the BRCA2 tumor suppressor protein.
    SequenceCaution:
    • Sequence=AAC26860.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC26860.1; Type=Frameshift; Positions=223; Evidence={ECO:0000305}; Sequence=AAH21585.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HMG20B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HMG20B Gene

Post-translational modifications for HMG20B Gene

  • Ubiquitination at Lys 208
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cloud-Clone Corp. Antibodies for HMG20B

No data available for DME Specific Peptides for HMG20B Gene

Domains & Families for HMG20B Gene

Gene Families for HMG20B Gene

Protein Domains for HMG20B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HMG20B Gene

Graphical View of Domain Structure for InterPro Entry

Q9P0W2

UniProtKB/Swiss-Prot:

HM20B_HUMAN :
  • Contains 1 HMG box DNA-binding domain.
Domain:
  • Contains 1 HMG box DNA-binding domain.
genes like me logo Genes that share domains with HMG20B: view

Function for HMG20B Gene

Molecular function for HMG20B Gene

UniProtKB/Swiss-Prot Function:
Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters.

Gene Ontology (GO) - Molecular Function for HMG20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004407 histone deacetylase activity TAS --
GO:0005515 protein binding IPI 21399666
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HMG20B: view

Phenotypes for HMG20B Gene

genes like me logo Genes that share phenotypes with HMG20B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HMG20B Gene

Localization for HMG20B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMG20B Gene

Nucleus. Chromosome. Note=Localized to condensed chromosomes in mitosis in conjunction with BRCA2.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HMG20B gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HMG20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with HMG20B: view

Pathways & Interactions for HMG20B Gene

genes like me logo Genes that share pathways with HMG20B: view

Gene Ontology (GO) - Biological Process for HMG20B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007049 cell cycle IEA --
GO:0007596 blood coagulation TAS --
GO:0016569 covalent chromatin modification IEA --
genes like me logo Genes that share ontologies with HMG20B: view

No data available for SIGNOR curated interactions for HMG20B Gene

Transcripts for HMG20B Gene

Unigene Clusters for HMG20B Gene

High mobility group 20B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HMG20B Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e ^
SP1: - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - -
SP9: - -
SP10: - - -
SP11:
SP12: - -
SP13: -
SP14:

ExUns: 11a · 11b · 11c ^ 12a · 12b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for HMG20B Gene

GeneLoc Exon Structure for
HMG20B
ECgene alternative splicing isoforms for
HMG20B

Expression for HMG20B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HMG20B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HMG20B Gene

This gene is overexpressed in Plasma (44.3), Placenta (11.4), and Peripheral blood mononuclear cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HMG20B Gene



Protein tissue co-expression partners for HMG20B Gene

NURSA nuclear receptor signaling pathways regulating expression of HMG20B Gene:

HMG20B

SOURCE GeneReport for Unigene cluster for HMG20B Gene:

Hs.406534

mRNA Expression by UniProt/SwissProt for HMG20B Gene:

Q9P0W2-HM20B_HUMAN
Tissue specificity: Ubiquitously expressed in adult tissues.
genes like me logo Genes that share expression patterns with HMG20B: view

No data available for mRNA differential expression in normal tissues for HMG20B Gene

Orthologs for HMG20B Gene

This gene was present in the common ancestor of animals.

Orthologs for HMG20B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HMG20B 35
  • 96 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia HMG20B 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HMG20B 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HMG20B 34 35
  • 86.73 (n)
rat
(Rattus norvegicus)
Mammalia Hmg20b 34
  • 86.54 (n)
mouse
(Mus musculus)
Mammalia Hmg20b 34 16 35
  • 85.49 (n)
oppossum
(Monodelphis domestica)
Mammalia HMG20B 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves HMG20B 34 35
  • 81.96 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia hmg20b 34
  • 66.55 (n)
MGC75938 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68625 34
zebrafish
(Danio rerio)
Actinopterygii hmg20b 34 35
  • 62.5 (n)
wufc85b02 34
fruit fly
(Drosophila melanogaster)
Insecta CG9418 35
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hmg-20 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToMany
Species where no ortholog for HMG20B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HMG20B Gene

ENSEMBL:
Gene Tree for HMG20B (if available)
TreeFam:
Gene Tree for HMG20B (if available)

Paralogs for HMG20B Gene

Paralogs for HMG20B Gene

genes like me logo Genes that share paralogs with HMG20B: view

Variants for HMG20B Gene

Sequence variations from dbSNP and Humsavar for HMG20B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10402774 -- 3,577,376(+) GCCGG(C/G)TCCCT intron-variant
rs10408835 -- 3,577,193(+) tcccc(C/T)gtcgc intron-variant
rs10420721 -- 3,575,424(+) GGGAA(C/T)AGGGA intron-variant
rs10424018 -- 3,579,383(+) CAACT(C/T)GTGTC downstream-variant-500B
rs10427050 -- 3,577,204(+) ccggc(A/G)ccgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMG20B Gene

Variant ID Type Subtype PubMed ID
nsv961165 CNV duplication 23825009
nsv953948 CNV deletion 24416366
nsv833713 CNV loss 17160897
nsv470114 CNV loss 18288195

Variation tolerance for HMG20B Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HMG20B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HMG20B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMG20B Gene

Disorders for HMG20B Gene

Relevant External Links for HMG20B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HMG20B

No disorders were found for HMG20B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMG20B Gene

Publications for HMG20B Gene

  1. A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression. (PMID: 11207365) Marmorstein L.Y. … Shiekhattar R. (Cell 2001) 3 4 22 64
  2. HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression. (PMID: 10773667) Sumoy L. … Peral B. (Cytogenet. Cell Genet. 2000) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for HMG20B Gene

Sources for HMG20B Gene

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