Aliases for HMG20A Gene
Aliases for HMG20A Gene
External Ids for HMG20A Gene
- HGNC: 5001
- Entrez Gene: 10363
- Ensembl: ENSG00000140382
- OMIM: 605534
- UniProtKB: Q9NP66
Previous GeneCards Identifiers for HMG20A Gene
- GC15P073605
- GC15P070803
- GC15P075289
- GC15P075429
- GC15P075500
- GC15P077712
- GC15P054470
Summaries for HMG20A Gene
GeneCards Summary for HMG20A Gene
HMG20A (High Mobility Group 20A) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is HMG20B.
UniProtKB/Swiss-Prot for HMG20A Gene
-
Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMG20A Gene
Genomics for HMG20A Gene
Regulatory Elements for HMG20A Gene
Regulatory Element Products
Genomic Location for HMG20A Gene
- Chromosome:
- 15
- Start:
- 77,420,412 bp from pter
- End:
- 77,485,607 bp from pter
- Size:
- 65,196 bases
- Orientation:
- Plus strand
Genomic View for HMG20A Gene
- Cytogenetic band:
-
- 15q24.3 by Ensembl
- 15q24.3 by Entrez Gene
- 15q24.3 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HMG20A Gene
Proteins for HMG20A Gene
-
Protein details for HMG20A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NP66-HM20A_HUMAN
- Recommended name:
- High mobility group protein 20A
- Protein Accession:
- Q9NP66
- A6NHY3
- D3DW78
- Q53G31
- Q9NSF6
Protein attributes for HMG20A Gene
- Size:
- 347 amino acids
- Molecular mass:
- 40144 Da
- Quaternary structure:
- No Data Available
Protein Expression for HMG20A Gene
Post-translational modifications for HMG20A Gene
Other Protein References for HMG20A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HMG20A
- Invitrogen Antibodies for HMG20A
- antibodies-online Antibodies for HMG20A: See all 69
- GeneTex HMG20A antibody for HMG20A
-
Santa Cruz Biotechnology (SCBT) Antibodies for HMG20A
Protein Products
-
OriGene Purified Proteins for HMG20A
- Search Origene for MassSpec and Protein Over-expression Lysates for HMG20A
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- antibodies-online Proteins for HMG20A: See all 6
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- Search GeneTex for Proteins for HMG20A
Assay Products
No data available for DME Specific Peptides for HMG20A Gene
Domains & Families for HMG20A Gene
Gene Families for HMG20A Gene
Protein Domains for HMG20A Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HMG20A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HMG20A Gene
Function for HMG20A Gene
Molecular function for HMG20A Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | NAS,IEA | 10773667 |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | NAS | 10773667 |
| GO:0004003 | ATP-dependent DNA helicase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0042802 | identical protein binding | IPI | 16189514 |
Phenotypes for HMG20A Gene
- GenomeRNAi human phenotypes for HMG20A:
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for HMG20A gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for HMG20A
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMG20A
- GenScript: Design CRISPR guide RNA sequences for HMG20A
miRNA for HMG20A Gene
- miRTarBase miRNAs that target HMG20A
miRNA Products
- Search ViGene Biosciences for HMG20A
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HMG20A
- Browse OriGene Inhibitory RNA Products For HMG20A
-
ViGene Biosciences ready-to-package AAV shRNAs for HMG20A gene
Clone Products
-
OriGene ORF clones in human for HMG20A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Addgene plasmids for HMG20A
Cell Line Products
-
Horizon Cell Lines for HMG20A
-
ViGene Biosciences adenoviral particle packaged cDNA for HMG20A gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HMG20A Gene
Localization for HMG20A Gene
Subcellular locations from UniProtKB/Swiss-Prot for HMG20A Gene
- Nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | NAS,IEA | 10773667 |
Pathways & Interactions for HMG20A Gene
Interacting Proteins for HMG20A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0006303 | double-strand break repair via nonhomologous end joining | IEA | -- |
| GO:0006325 | chromatin organization | NAS | 10773667 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | NAS | 10773667 |
No data available for Pathways by source and SIGNOR curated interactions for HMG20A Gene
Transcripts for HMG20A Gene
mRNA/cDNA for HMG20A Gene
- (4) REFSEQ mRNAs :
- (16) Additional mRNA sequences :
- (229) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HMG20A Gene
CRISPR Products
-
OriGene CRISPR knockouts for HMG20A
-
Santa Cruz Biotechnology (SCBT) CRISPR for HMG20A
- GenScript: Design CRISPR guide RNA sequences for HMG20A
miRNA Products
- Search ViGene Biosciences for HMG20A
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HMG20A
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-
ViGene Biosciences ready-to-package AAV shRNAs for HMG20A gene
Clone Products
-
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- Addgene plasmids for HMG20A
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||
| SP7: |
Expression for HMG20A Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HMG20A Gene
NURSA nuclear receptor signaling pathways regulating expression of HMG20A Gene:
HMG20ASOURCE GeneReport for Unigene cluster for HMG20A Gene:
Hs.69594mRNA Expression by UniProt/SwissProt for HMG20A Gene:
Q9NP66-HM20A_HUMANEvidence on tissue expression from TISSUES for HMG20A Gene
- Nervous system(4.6)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for HMG20A
-
OriGene qPCR primer pairs for HMG20A
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMG20A Gene
Orthologs for HMG20A Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HMG20A 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HMG20A 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HMG20A 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HMG20A 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Hmg20a 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hmg20a 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HMG20A 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
OneToMany | |
| HMG20A 34 35 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | HMG20A 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.8432 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.7860 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hmg20a 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004791 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9418 35 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | hmg-20 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NHP6A 37 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HMG20A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HMG20A Gene
(1) SIMAP similar genes for HMG20A Gene using alignment to 8 proteins:
Variants for HMG20A Gene
| SNP ID | Clin | Chr 15 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000005727 | -- | 77,519,033(+) | TTTCC(A/T)TTTAG | intron-variant | |
| rs1000026812 | -- | 77,506,543(+) | TTTGC(C/T)TTTGT | intron-variant | |
| rs1000055606 | -- | 77,460,788(+) | CAAGA(A/C/G)CAGCC | intron-variant | |
| rs1000063169 | -- | 77,467,566(+) | TTCAC(A/C)TAAGA | intron-variant | |
| rs1000122216 | -- | 77,513,123(+) | GTAAT(A/C)ATGGA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2660058 | CNV | deletion | 23128226 |
| esv2749898 | CNV | deletion | 23290073 |
| esv3306898 | CNV | mobile element insertion | 20981092 |
| esv3362224 | CNV | insertion | 20981092 |
| esv3552706 | CNV | deletion | 23714750 |
| esv3636966 | CNV | loss | 21293372 |
| nsv1040852 | CNV | gain | 25217958 |
| nsv1043284 | CNV | gain | 25217958 |
| nsv1116463 | OTHER | inversion | 24896259 |
| nsv570139 | CNV | loss | 21841781 |
Relevant External Links for HMG20A Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMG20A Gene
Disorders for HMG20A Gene
Relevant External Links for HMG20A
No disorders were found for HMG20A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMG20A Gene
Publications for HMG20A Gene
- HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression. (PMID: 10773667) Sumoy L. … Peral B. (Cytogenet. Cell Genet. 2000) 2 3 4 64
- Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X. … Tai E.S. (PLoS Genet. 2011) 3 46 64
- Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. (PMID: 21874001) Kooner J.S. … Chambers J.C. (Nat. Genet. 2011) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for HMG20A Gene
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- OriGene qPCR primer pairs and template standards for HMG20A
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- GenScript: Next-day shipping cDNA ORF clone for HMG20A in any vector
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- GenScript: Design CRISPR guide RNA sequences for HMG20A
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- Novus Biologicals Antibodies for HMG20A
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- Novus Biologicals
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- Addgene plasmids for HMG20A
- antibodies-online Antibodies for HMG20A: See all 69
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- antibodies-online Proteins for HMG20A: See all 6
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- GeneTex HMG20A antibody for HMG20A
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- ViGene Biosciences adenoviral particle packaged cDNA for HMG20A gene
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- VectorBuilder custom plasmid, inducible vectors for HMG20A
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HMG20A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




