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HMG20A Gene

protein-coding   GIFtS: 54
GCID: GC15P077712

High Mobility Group 20A

(Previous name: high-mobility group 20A)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
High Mobility Group 20A1 2     HMG Box-Containing Protein 20A2 3
High-Mobility Group 20A1 2     HMG Domain-Containing Protein 12 3
HMG Box Domain Containing 11 2     HMG Domain-Containing Protein HMGX12 3
HMGX12 3     High Mobility Group Protein 20A2
HMGXB12 3     

External Ids:    HGNC: 50011   Entrez Gene: 103632   Ensembl: ENSG000001403827   OMIM: 6055345   UniProtKB: Q9NP663   

Export aliases for HMG20A gene to outside databases

Previous GC identifers: GC15P073605 GC15P070803 GC15P075289 GC15P075429 GC15P075500 GC15P054470


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HMG20A Gene:
HMG20A (high mobility group 20A) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HMG20B.

UniProtKB/Swiss-Prot: HM20A_HUMAN, Q9NP66
Function: Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B.
Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific
genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased
methylation of histone H3 lysine 4 (By similarity)

Gene Wiki entry for HMG20A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HMG20A gene promoter:
         HOXA9   HOXA9B   MEF-2   ATF-2   CUTL1   HNF-3beta   MEF-2A   Meis-1a   aMEF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHMG20A promoter sequence
   Search Chromatin IP Primers for HMG20A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMG20A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q24.3   HGNC cytogenetic band: 15q24

HMG20A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMG20A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P077712:  view genomic region     (about GC identifiers)

Start:
77,712,754 bp from pter      End:
77,777,949 bp from pter
Size:
65,196 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HM20A_HUMAN, Q9NP66 (See protein sequence)
Recommended Name: High mobility group protein 20A  
Size: 347 amino acids; 40144 Da
Secondary accessions: A6NHY3 D3DW78 Q53G31 Q9NSF6
Alternative splicing: 2 isoforms:  Q9NP66-1   Q9NP66-2   

Explore the universe of human proteins at neXtProt for HMG20A: NX_Q9NP66

Explore proteomics data for HMG20A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys230
  • Modification sites at PhosphoSitePlus

  • See HMG20A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060670.1  
    ENSEMBL proteins: 
     ENSP00000453498   ENSP00000336856   ENSP00000371133   ENSP00000453727   ENSP00000453592  
     ENSP00000452665   ENSP00000454136   ENSP00000452864   ENSP00000452847  

    HMG20A Human Recombinant Protein Products:

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    Novus Biologicals HMG20A Proteins
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HMG20A

     
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    antibodies-online proteins for HMG20A (5 products) 

     
    antibodies-online peptides for HMG20A

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HMGX: High mobility group / Non-canonical

    1 InterPro protein domain:
     IPR009071 HMG_box_dom

    Graphical View of Domain Structure for InterPro Entry Q9NP66

    ProtoNet protein and cluster: Q9NP66

    UniProtKB/Swiss-Prot: HM20A_HUMAN, Q9NP66
    Similarity: Contains 1 HMG box DNA-binding domain


    Find genes that share domains with HMG20A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HM20A_HUMAN, Q9NP66
    Function: Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B.
    Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific
    genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased
    methylation of histone H3 lysine 4 (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS10773667
    GO:0003700sequence-specific DNA binding transcription factor activity NAS10773667
    GO:0005515protein binding IPI16189514
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with HMG20A           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HMG20A

    miRNA
    Products:
        
    miRTarBase miRNAs that target HMG20A:
    hsa-mir-30c-5p (MIRT047829), hsa-mir-20a-5p (MIRT050496)

    Block miRNA regulation of human, mouse, rat HMG20A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HMG20A (see all 46):
    hsa-miR-607 hsa-miR-218-1* hsa-miR-200a hsa-miR-141 hsa-miR-9 hsa-miR-654-5p hsa-miR-4309 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidHMG20A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HMG20A

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    GenScript: all cDNA clones in your preferred vector: HMG20A (NM_018200)
    Sino Biological Human cDNA Clone for HMG20A
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMG20A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HM20A_HUMAN, Q9NP66: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS10773667

    Find genes that share ontologies with HMG20A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HMG20A
    Interactions:

        Search GeneGlobe Interaction Network for HMG20A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HMG20A (Q9NP661, 2, 3 ENSP000003368564) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TESCQ96BS21, 2, 3, ENSP000003763284EBI-740641,EBI-740653 MINT-66093 I2D: score=5 STRING: ENSP00000376328
    CCNKO759092, 3, ENSP000003745294MINT-68052 I2D: score=5 STRING: ENSP00000374529
    MAGOHBQ96A722, 3, ENSP000003192404MINT-66920 I2D: score=5 STRING: ENSP00000319240
    RBM7Q9Y5802, 3, ENSP000003646394MINT-68043 I2D: score=5 STRING: ENSP00000364639
    SMAD4Q134852, 3MINT-61963 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006325chromatin organization NAS10773667
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated NAS10773667
    GO:0016568chromatin modification IEA--

    Find genes that share ontologies with HMG20A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HMG20A (HM20A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HMG20A gene: 
    NM_018200.2  

    Unigene Cluster for HMG20A:

    High mobility group 20A
    Hs.69594  [show with all ESTs]
    Unigene Representative Sequence: NM_018200
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560498 ENST00000336216(uc002bcs.3) ENST00000381714(uc002bcr.3)
    ENST00000558651 ENST00000559035 ENST00000558176 ENST00000560986(uc002bcq.1)
    ENST00000559099 ENST00000560867 ENST00000559728 ENST00000558845 ENST00000558288(uc021sra.1)

    miRNA
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    Block miRNA regulation of human, mouse, rat HMG20A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HMG20A (see all 46):
    hsa-miR-607 hsa-miR-218-1* hsa-miR-200a hsa-miR-141 hsa-miR-9 hsa-miR-654-5p hsa-miR-4309 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidHMG20A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HMG20A
    Predesigned siRNA for gene silencing in human, mouse, rat HMG20A
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    GenScript: all cDNA clones in your preferred vector: HMG20A (NM_018200)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HMG20A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMG20A
    Primer
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    OriGene qPCR primer pairs and template standards for HMG20A
    OriGene qSTAR qPCR primer pairs in human, mouse for HMG20A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HMG20A
      QuantiTect SYBR Green Assays in human, mouse, rat HMG20A
      QuantiFast Probe-based Assays in human, mouse, rat HMG20A

    Additional mRNA sequence: 

    AB073664.1 AF146222.1 AK001601.1 AK025664.1 AK096546.1 AK223100.1 AK297449.1 AK311376.1 
    AK316281.1 AL355733.1 AL355737.1 AL355738.1 AL355739.1 AL832087.1 BC021959.1 BT006716.1 

    15 DOTS entries:

    DT.100789667  DT.416983  DT.100789671  DT.91746166  DT.101981671  DT.97810013  DT.121070456  DT.97806707 
    DT.40309937  DT.100709430  DT.121070459  DT.95075677  DT.100789670  DT.121070465  DT.91800429 

    Selected AceView cDNA sequences (see all 229):

    BP376105 AK096546 BM927077 H80631 CK430541 CA848796 NM_018200 BQ717570 
    BQ050623 BU620952 BQ128250 BI913106 BE301304 R80124 BQ897605 BE221793 
    AU130805 BI467051 BP379831 AA363760 AI685985 AA995584 BQ920999 AA582488 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HMG20A (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
    SP1:                          -                                                     -                       -               
    SP2:                          -                                                                                             
    SP3:                          -     -                                                                                       
    SP4:                                                                                                        -               
    SP5:                    -     -                                                                                             


    ECgene alternative splicing isoforms for HMG20A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HMG20A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTGGAAC
    HMG20A Expression
    About this image


    HMG20A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mandibular Condyle
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    HMG20A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HMG20A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.69594

    UniProtKB/Swiss-Prot: HM20A_HUMAN, Q9NP66
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for HMG20A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMG20A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HMG20A gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hmg20a1 , 5 high mobility group 20A1, 5 91.62(n)1
    96.24(a)1
      9 (30.13 cM)5
    668671  NM_025812.21  NP_080088.11 
     564188465 
    chicken
    (Gallus gallus)
    Aves HMG20A1 high mobility group 20A 78(n)
    83.86(a)
      415346  NM_001030394.1  NP_001025565.1 
    lizard
    (Anolis carolinensis)
    Reptilia HMG20A6
    high mobility group 20A
    78(a)
    1 ↔ 1
    GL343374.1(820023-846413)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.78602 Xenopus laevis transcribed sequence with weak similarity more 76.72(n)    BJ073811.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmg20a1 high-mobility group 20A 69.11(n)
    74.13(a)
      326908  NM_001089334.1  NP_001082803.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG94181 CG9418 47.73(n)
    34.4(a)
      37407  NM_137709.3  NP_611553.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hmg-206
    Protein HMG-20 (hmg-20) mRNA, complete cds
    19(a)
    1 → many
    I(12535322-12537671) WBGene00012209


    ENSEMBL Gene Tree for HMG20A (if available)
    TreeFam Gene Tree for HMG20A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HMG20A gene
    HMG20B2  
    1 SIMAP similar gene for HMG20A using alignment to 8 protein entries:     HM20A_HUMAN (see all proteins):
    HMG20B

    Find genes that share paralogs with HMG20A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HMG20A (see all 1109)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1441175991,2
    --57750740(+) AATGAC/TCTAAA 1 -- us2k10--------
    rs125935821,2
    C,F,H--57750824(+) AAAATG/CAATTA 1 -- us2k115Minor allele frequency- C:0.12NS EA NA WA CSA 675
    rs750925781,2
    F--57750867(+) TCATAG/CTTTTC 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1876467121,2
    --57751072(+) GAAATC/TAAGCT 1 -- us2k10--------
    rs1459861651,2
    --57751102(+) CGACGA/GGAGGG 1 -- us2k10--------
    rs1399723731,2
    --57751108(+) GAGGGA/GAGGGG 1 -- us2k10--------
    rs765334511,2
    C,F--57751152(+) AGGAGG/AAAAGA 1 -- us2k11Minor allele frequency- A:0.02NA 120
    rs620072991,2
    C,F--57751177(+) GGATGA/GGTCAA 1 -- us2k19Minor allele frequency- G:0.48NA WA CSA EA 369
    rs1925319471,2
    C--57751202(+) AAAAAA/CTGAGC 1 -- us2k10--------
    rs1836132281,2
    --57751245(+) GCCAGC/GCCACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HMG20A (77712754 - 77777949 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HMG20A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660058CNV Deletion23128226
    esv2749898CNV Deletion23290073
    esv271174CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605534    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for HMG20A:
    Cowpox

    Find genes that share disorders with HMG20A           About GenesLikeMe

    Genetic Association Database (GAD): HMG20A

    Export disorders for HMG20A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HMG20A gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with HMG20A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression. (PubMed id 10773667)1, 2, 3 Sumoy L.... Peral B. (Cytogenet. Cell Genet. 2000)
    2. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. (PubMed id 21874001)1, 4 Kooner J.S....Chambers J.C. (Nat. Genet. 2011)
    3. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PubMed id 21490949)1, 4 Sim X....Tai E.S. (PLoS Genet. 2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Development and application of a DNA microarray-based yeast two-hybrid system. (PubMed id 23275563)1 Suter B....Wanker E.E. (Nucleic Acids Res. 2013)
    7. The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins. (PubMed id 23707952)1 Davies R.G....Jans D.A. (Biochim. Biophys. Acta 2013)
    8. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    9. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10363 HGNC: 5001 AceView: HMG20A Ensembl:ENSG00000140382 euGenes: HUgn10363
    ECgene: HMG20A H-InvDB: HMG20A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HMG20A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HMG20A gene:
    Search GeneIP for patents involving HMG20A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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