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Aliases for HMG20A Gene

Aliases for HMG20A Gene

  • High Mobility Group 20A 2 3
  • HMG Domain-Containing Protein HMGX1 3 4
  • HMG Domain-Containing Protein 1 3 4
  • HMG Box-Containing Protein 20A 3 4
  • HMG Box Domain Containing 1 2 3
  • HMGXB1 3 4
  • HMGX1 3 4
  • High Mobility Group Protein 20A 3
  • High-Mobility Group 20A 2

External Ids for HMG20A Gene

Summaries for HMG20A Gene

GeneCards Summary for HMG20A Gene

HMG20A (High Mobility Group 20A) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is HMG20B.

UniProtKB/Swiss-Prot for HMG20A Gene

  • Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity).

Gene Wiki entry for HMG20A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMG20A Gene

Genomics for HMG20A Gene

Genomic Location for HMG20A Gene

Start:
77,420,412 bp from pter
End:
77,485,607 bp from pter
Size:
65,196 bases
Orientation:
Plus strand

Genomic View for HMG20A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMG20A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMG20A Gene

Regulatory Elements for HMG20A Gene

Proteins for HMG20A Gene

  • Protein details for HMG20A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP66-HM20A_HUMAN
    Recommended name:
    High mobility group protein 20A
    Protein Accession:
    Q9NP66
    Secondary Accessions:
    • A6NHY3
    • D3DW78
    • Q53G31
    • Q9NSF6

    Protein attributes for HMG20A Gene

    Size:
    347 amino acids
    Molecular mass:
    40144 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HMG20A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HMG20A Gene

Proteomics data for HMG20A Gene at MOPED

Post-translational modifications for HMG20A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys230

No data available for DME Specific Peptides for HMG20A Gene

Domains for HMG20A Gene

Gene Families for HMG20A Gene

HGNC:
  • HMGX :High mobility group / Non-canonical

Protein Domains for HMG20A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

HM20A_HUMAN
Domain:
  • Contains 1 HMG box DNA-binding domain.:
    • Q9NP66
genes like me logo Genes that share domains with HMG20A: view

Function for HMG20A Gene

Molecular function for HMG20A Gene

UniProtKB/Swiss-Prot Function: Plays a role in neuronal differentiation as chromatin-associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4 (By similarity).

Gene Ontology (GO) - Molecular Function for HMG20A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 10773667
GO:0003682 chromatin binding IBA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 10773667
GO:0005515 protein binding IPI 16189514
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HMG20A: view

miRNA for HMG20A Gene

miRTarBase miRNAs that target HMG20A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HMG20A Gene

Localization for HMG20A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMG20A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMG20A Gene COMPARTMENTS Subcellular localization image for HMG20A gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for HMG20A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10773667
genes like me logo Genes that share ontologies with HMG20A: view

Pathways for HMG20A Gene

SuperPathways for HMG20A Gene

No Data Available

Gene Ontology (GO) - Biological Process for HMG20A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006325 chromatin organization NAS 10773667
GO:0006338 chromatin remodeling IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 10773667
genes like me logo Genes that share ontologies with HMG20A: view

No data available for Pathways by source for HMG20A Gene

Transcripts for HMG20A Gene

Unigene Clusters for HMG20A Gene

High mobility group 20A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMG20A Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
SP1: - - -
SP2: -
SP3: - -
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for HMG20A Gene

GeneLoc Exon Structure for
HMG20A
ECgene alternative splicing isoforms for
HMG20A

Expression for HMG20A Gene

mRNA expression in normal human tissues for HMG20A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMG20A Gene

SOURCE GeneReport for Unigene cluster for HMG20A Gene Hs.69594

mRNA Expression by UniProt/SwissProt for HMG20A Gene

Q9NP66-HM20A_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with HMG20A: view

Orthologs for HMG20A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HMG20A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMG20A 36
  • 99.71 (n)
  • 99.71 (a)
HMG20A 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HMG20A 36
  • 94.24 (n)
  • 97.98 (a)
HMG20A 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HMG20A 36
  • 95 (n)
  • 97.12 (a)
HMG20A 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmg20a 36
  • 91.62 (n)
  • 96.24 (a)
Hmg20a 16
Hmg20a 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HMG20A 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HMG20A 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hmg20a 36
  • 90.59 (n)
  • 95.97 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 89 (a)
OneToMany
HMG20A 36
  • 78 (n)
  • 83.86 (a)
HMG20A 37
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia HMG20A 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7860 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8432 36
zebrafish
(Danio rerio)
Actinopterygii hmg20a 36
  • 69.11 (n)
  • 74.13 (a)
hmg20a 37
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004791 36
  • 49.21 (n)
  • 38.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9418 36
  • 47.73 (n)
  • 34.4 (a)
CG9418 37
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hmg-20 37
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NHP6A 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToMany
Species with no ortholog for HMG20A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HMG20A Gene

ENSEMBL:
Gene Tree for HMG20A (if available)
TreeFam:
Gene Tree for HMG20A (if available)

Paralogs for HMG20A Gene

Paralogs for HMG20A Gene

Selected SIMAP similar genes for HMG20A Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with HMG20A: view

Variants for HMG20A Gene

Sequence variations from dbSNP and Humsavar for HMG20A Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs7119 -- 77,485,290(-) CATGA(A/G)TTAGG utr-variant-3-prime
rs907398 -- 77,479,661(-) AGCCA(C/T)AAAAA intron-variant
rs907399 -- 77,478,697(-) GAGCC(G/T)GAAAC intron-variant
rs937236 -- 77,423,306(+) GAGAG(A/G)GAAGG intron-variant
rs937237 -- 77,455,527(+) TAATA(C/T)CATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HMG20A Gene

Variant ID Type Subtype PubMed ID
esv2749898 CNV Deletion 23290073
esv271174 CNV Insertion 20981092
esv2660058 CNV Deletion 23128226

Relevant External Links for HMG20A Gene

HapMap Linkage Disequilibrium report
HMG20A

Disorders for HMG20A Gene

(1) University of Copenhagen DISEASES for HMG20A Gene

Relevant External Links for HMG20A

Genetic Association Database (GAD)
HMG20A
genes like me logo Genes that share disorders with HMG20A: view

No data available for UniProtKB/Swiss-Prot for HMG20A Gene

Publications for HMG20A Gene

  1. HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression. (PMID: 10773667) Sumoy L. … Peral B. (Cytogenet. Cell Genet. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X. … Tai E.S. (PLoS Genet. 2011) 3 49
  5. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. (PMID: 21874001) Kooner J.S. … Chambers J.C. (Nat. Genet. 2011) 3 49

Products for HMG20A Gene

Sources for HMG20A Gene

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