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Aliases for HMCN2 Gene

Aliases for HMCN2 Gene

  • Hemicentin 2 2 3 5

External Ids for HMCN2 Gene

Previous GeneCards Identifiers for HMCN2 Gene

  • GC09P132213
  • GC09P133223
  • GC09P102707
  • GC09P133029

Summaries for HMCN2 Gene

GeneCards Summary for HMCN2 Gene

HMCN2 (Hemicentin 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is MYBPC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMCN2 Gene

Genomics for HMCN2 Gene

Regulatory Elements for HMCN2 Gene

Genomic Location for HMCN2 Gene

130,265,759 bp from pter
130,434,123 bp from pter
168,365 bases
Plus strand

Genomic View for HMCN2 Gene

Genes around HMCN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMCN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMCN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMCN2 Gene

Proteins for HMCN2 Gene

  • Protein details for HMCN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A0A096LP30
    • Q8N225
    • Q8TCI8

    Protein attributes for HMCN2 Gene

    5059 amino acids
    Molecular mass:
    541978 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB85069.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04201.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD38854.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=EAW87931.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for HMCN2 Gene


neXtProt entry for HMCN2 Gene

Proteomics data for HMCN2 Gene at MOPED

Post-translational modifications for HMCN2 Gene

  • Glycosylation at Asn 329, Asn 346, Asn 379, Asn 478, Asn 525, Asn 547, Asn 674, Asn 1024, Asn 1223, Asn 1309, Asn 1507, Asn 1533, Asn 1641, Asn 1900, Asn 2000, Asn 2079, Asn 2085, Asn 2243, Asn 2281, Asn 2361, Asn 2435, Asn 2468, Asn 2507, Asn 2572, Asn 2654, Asn 2858, Asn 2952, Asn 3396, Asn 3526, Asn 3541, Asn 3683, Asn 3687, Asn 3772, Asn 4068, Asn 4270, Asn 4421, Asn 4567, Asn 4810, and Asn 5000
  • Modification sites at PhosphoSitePlus

Other Protein References for HMCN2 Gene

No data available for DME Specific Peptides for HMCN2 Gene

Domains & Families for HMCN2 Gene

Suggested Antigen Peptide Sequences for HMCN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 EGF-like domains.
  • Contains 5 EGF-like domains.
  • Contains 42 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 nidogen G2 beta-barrel domain.
  • Contains 1 VWFA domain.
genes like me logo Genes that share domains with HMCN2: view

Function for HMCN2 Gene

genes like me logo Genes that share phenotypes with HMCN2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HMCN2 Gene

Localization for HMCN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMCN2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for HMCN2 Gene COMPARTMENTS Subcellular localization image for HMCN2 gene
Compartment Confidence
extracellular 3
cytosol 2
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HMCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with HMCN2: view

Pathways & Interactions for HMCN2 Gene

SuperPathways for HMCN2 Gene

No Data Available

Interacting Proteins for HMCN2 Gene

Gene Ontology (GO) - Biological Process for HMCN2 Gene


No data available for Pathways by source and SIGNOR curated interactions for HMCN2 Gene

Drugs & Compounds for HMCN2 Gene

No Compound Related Data Available

Transcripts for HMCN2 Gene

mRNA/cDNA for HMCN2 Gene

(8) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HMCN2 Gene

Hemicentin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMCN2 Gene

No ASD Table

Relevant External Links for HMCN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HMCN2 Gene

mRNA expression in normal human tissues for HMCN2 Gene

mRNA differential expression in normal tissues according to GTEx for HMCN2 Gene

This gene is overexpressed in Colon - Sigmoid (x9.2) and Small Intestine - Terminal Ileum (x4.4).

Protein differential expression in normal tissues from HIPED for HMCN2 Gene

This gene is overexpressed in Plasma (22.9), Serum (17.6), and Colon (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HMCN2 Gene

SOURCE GeneReport for Unigene cluster for HMCN2 Gene Hs.32194

genes like me logo Genes that share expression patterns with HMCN2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HMCN2 Gene

Orthologs for HMCN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HMCN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HMCN2 35
  • 85.64 (n)
  • 83.6 (a)
HMCN2 36
  • 13 (a)
(Canis familiaris)
Mammalia HMCN2 35
  • 85.24 (n)
  • 83.9 (a)
HMCN2 36
  • 13 (a)
(Mus musculus)
Mammalia Hmcn2 35
  • 81.39 (n)
  • 81.12 (a)
Hmcn2 16
Hmcn2 36
  • 13 (a)
(Rattus norvegicus)
Mammalia Hmcn2 35
  • 81.12 (n)
  • 80.82 (a)
(Monodelphis domestica)
Mammalia HMCN2 36
  • 10 (a)
(Ornithorhynchus anatinus)
Mammalia HMCN2 36
  • 66 (a)
(Pan troglodytes)
Mammalia HMCN2 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hmcn2 35
  • 57.74 (n)
  • 51.07 (a)
(Danio rerio)
Actinopterygii hmcn2 36
  • 11 (a)
(Caenorhabditis elegans)
Secernentea him-4 36
  • 3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
Species with no ortholog for HMCN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HMCN2 Gene

Gene Tree for HMCN2 (if available)
Gene Tree for HMCN2 (if available)

Paralogs for HMCN2 Gene

Paralogs for HMCN2 Gene

genes like me logo Genes that share paralogs with HMCN2: view

Variants for HMCN2 Gene

Sequence variations from dbSNP and Humsavar for HMCN2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs13201 -- 130,433,937(+) CCGGG(A/G/T)AAGCC utr-variant-3-prime
rs867943 -- 130,370,645(+) GGTCC(C/T)ACTGG intron-variant
rs870748 -- 130,289,566(-) acaca(A/G)gaaga intron-variant
rs1105621 -- 130,287,954(-) GAGTT(A/G)AGGCA intron-variant
rs1105796 -- 130,288,675(+) TTTGC(C/T)GAGCT intron-variant

Variation tolerance for HMCN2 Gene

Gene Damage Index Score: 9.72; 89.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HMCN2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HMCN2 Gene

Disorders for HMCN2 Gene

Relevant External Links for HMCN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HMCN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMCN2 Gene

Publications for HMCN2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) KAPnig R. … Chanda S.K. (Cell 2008) 3
  3. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. (PMID: 12388743) Whittaker C.A. … Hynes R.O. (Mol. Biol. Cell 2002) 3

Products for HMCN2 Gene

Sources for HMCN2 Gene

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