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Aliases for HMCN2 Gene

Aliases for HMCN2 Gene

  • Hemicentin 2 2 3
  • Hemicentin-2 3

External Ids for HMCN2 Gene

Previous GeneCards Identifiers for HMCN2 Gene

  • GC09P132213
  • GC09P133223
  • GC09P102707
  • GC09P133029

Summaries for HMCN2 Gene

GeneCards Summary for HMCN2 Gene

HMCN2 (Hemicentin 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is LTBP3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMCN2 Gene

Genomics for HMCN2 Gene

Regulatory Elements for HMCN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HMCN2 Gene

130,265,879 bp from pter
130,434,123 bp from pter
168,245 bases
Plus strand

Genomic View for HMCN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMCN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMCN2 Gene

Proteins for HMCN2 Gene

  • Protein details for HMCN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8N225
    • Q8TCI8

    Protein attributes for HMCN2 Gene

    5065 amino acids
    Molecular mass:
    542605 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB85069.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04201.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW87931.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for HMCN2 Gene


neXtProt entry for HMCN2 Gene

Proteomics data for HMCN2 Gene at MOPED

Post-translational modifications for HMCN2 Gene

  • Glycosylation at Asn329, Asn346, Asn379, Asn478, Asn525, Asn547, Asn674, Asn1024, Asn1223, Asn1309, Asn1507, Asn1533, Asn1641, Asn1900, Asn2000, Asn2079, Asn2085, Asn2243, Asn2281, Asn2361, Asn2435, Asn2468, Asn2507, Asn2572, Asn2654, Asn2858, Asn2952, Asn3396, Asn3526, Asn3541, Asn3683, Asn3687, Asn3772, Asn4068, Asn4270, Asn4421, Asn4567, Asn4810, and Asn5000
  • Modification sites at PhosphoSitePlus

Other Protein References for HMCN2 Gene

No data available for DME Specific Peptides for HMCN2 Gene

Domains for HMCN2 Gene

Suggested Antigen Peptide Sequences for HMCN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 EGF-like domains.
  • Contains 5 EGF-like domains.
  • Contains 42 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 nidogen G2 beta-barrel domain.
  • Contains 1 VWFA domain.
genes like me logo Genes that share domains with HMCN2: view

Function for HMCN2 Gene

Gene Ontology (GO) - Molecular Function for HMCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with HMCN2: view

Phenotypes for HMCN2 Gene

GenomeRNAi human phenotypes for HMCN2:
genes like me logo Genes that share phenotypes with HMCN2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HMCN2 Gene

Localization for HMCN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMCN2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for HMCN2 Gene COMPARTMENTS Subcellular localization image for HMCN2 gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HMCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005604 basement membrane --
GO:0005938 cell cortex --
GO:0030054 cell junction --
genes like me logo Genes that share ontologies with HMCN2: view

Pathways for HMCN2 Gene

SuperPathways for HMCN2 Gene

No Data Available

Interacting Proteins for HMCN2 Gene

Gene Ontology (GO) - Biological Process for HMCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with HMCN2: view

No data available for Pathways by source for HMCN2 Gene

Transcripts for HMCN2 Gene

mRNA/cDNA for HMCN2 Gene

(8) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HMCN2 Gene

Hemicentin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMCN2 Gene

No ASD Table

Relevant External Links for HMCN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HMCN2 Gene

mRNA expression in normal human tissues for HMCN2 Gene

mRNA differential expression in normal tissues according to GTEx for HMCN2 Gene

This gene is overexpressed in Colon - Sigmoid (9.2) and Small Intestine - Terminal Ileum (4.4).

Protein differential expression in normal tissues for HMCN2 Gene

This gene is overexpressed in Plasma (22.9), Serum (17.6), and Colon (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HMCN2 Gene

SOURCE GeneReport for Unigene cluster for HMCN2 Gene Hs.32194

genes like me logo Genes that share expressions with HMCN2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Expression partners for HMCN2 Gene

Orthologs for HMCN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HMCN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HMCN2 35
  • 85.64 (n)
  • 83.6 (a)
HMCN2 36
  • 13 (a)
(Canis familiaris)
Mammalia HMCN2 35
  • 85.24 (n)
  • 83.9 (a)
HMCN2 36
  • 13 (a)
(Mus musculus)
Mammalia Hmcn2 35
  • 81.39 (n)
  • 81.12 (a)
Hmcn2 16
Hmcn2 36
  • 13 (a)
(Rattus norvegicus)
Mammalia Hmcn2 35
  • 81.12 (n)
  • 80.82 (a)
(Monodelphis domestica)
Mammalia HMCN2 36
  • 10 (a)
(Ornithorhynchus anatinus)
Mammalia HMCN2 36
  • 66 (a)
(Pan troglodytes)
Mammalia HMCN2 36
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hmcn2 35
  • 57.74 (n)
  • 51.07 (a)
(Danio rerio)
Actinopterygii hmcn2 36
  • 11 (a)
(Caenorhabditis elegans)
Secernentea him-4 36
  • 3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
Species with no ortholog for HMCN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HMCN2 Gene

Gene Tree for HMCN2 (if available)
Gene Tree for HMCN2 (if available)

Paralogs for HMCN2 Gene

genes like me logo Genes that share paralogs with HMCN2: view

Variants for HMCN2 Gene

Sequence variations from dbSNP and Humsavar for HMCN2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs11243582 -- 130,363,864(+) gagag(A/G)gaagg intron-variant
rs11243581 -- 130,363,863(+) agaga(A/G)agaag intron-variant
rs11243580 -- 130,363,841(+) aaaga(A/G)agaga intron-variant
rs11243579 -- 130,363,831(+) aaaaa(A/G)aaaga intron-variant
rs11243578 -- 130,363,808(+) ataga(C/G)ccaga intron-variant

Relevant External Links for HMCN2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HMCN2 Gene

Disorders for HMCN2 Gene

Relevant External Links for HMCN2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for HMCN2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HMCN2 Gene

Publications for HMCN2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4
  5. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) KAPnig R. … Chanda S.K. (Cell 2008) 3

Products for HMCN2 Gene

Sources for HMCN2 Gene

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