HMCN2 Gene
protein-coding GIFtS: 37
GCID: GC09P133029
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hemicentin 2
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Aliases
for HMCN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hemicentin 21 2 | | DKFZp434P02161 | | FLJ238161 | | Hemicentin-21 |
Export aliases for HMCN2 gene to outside databasesPrevious GC identifers: GC09P130263 GC09P132213 GC09P133223 GC09P102707 |
Summaries
for HMCN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for HMCN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NT_035014.4 NC_018920.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HMCN2 gene promoter:
Pax-5 RREB-1 p300 GATA-2 AREB6 CREB PPAR-gamma1 CP2 PPAR-gamma2 Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HMCN2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMCN2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.11 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.11HMCN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P133029: view genomic region
(about GC identifiers)
Start:
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133,028,269 bp from pter |
End:
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133,309,510 bp from pter |
Size:
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281,242 bases |
Orientation:
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plus strand |
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Proteins
for HMCN2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HMCN2_HUMAN, Q8NDA2 (See
protein sequence)Recommended Name: Hemicentin-2 precursor Size: 5065 amino acids; 542605 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Sequence caution: Sequence=BAB85069.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAC04201.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW87931.1;Type=Erroneous gene model prediction;
Secondary accessions: Q8N225 Q8TCI8Alternative splicing: 3 isoforms: Q8NDA2-1 Q8NDA2-2 Q8NDA2-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for HMCN2: NX_Q8NDA2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NDA2
HMCN2 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000389272 ENSP00000389821 ENSP00000413769 ENSP00000395966 ENSP00000387564 ENSP00000305590
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
HMCN2 for ontologies About GeneDecksing
HMCN2 Antibody Products:
Assay Products for HMCN2: |
Protein
Domains /
Families
for HMCN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HMCN2 for domains About GeneDecksing
5/16 InterPro domains/families (see all 16):Graphical View of Domain Structure for InterPro Entry Q8NDA2ProtoNet protein and cluster: Q8NDA2 2 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB013098 Immunoglobulin I-set
UniProtKB/Swiss-Prot: HMCN2_HUMAN, Q8NDA2Similarity: Contains 5 EGF-like domainsSimilarity: Contains 42 Ig-like C2-type (immunoglobulin-like) domainsSimilarity: Contains 1 nidogen G2 beta-barrel domainSimilarity: Contains 1 VWFA domain |
Function
for HMCN2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMCN2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- |
HMCN2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for HMCN2:
|
Pathways & Interactions
for HMCN2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HMCN2
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0050896 | response to stimulus |
IEA | -- |
HMCN2 for ontologies About GeneDecksing
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Drugs & Compounds
for HMCN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HMCN2
Search CenterWatch for drugs/clinical trials and news about HMCN2 
|
Transcripts
for HMCN2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HMCN2 gene: NM_144655.1 Unigene Clusters for HMCN2: Hemicentin 2 Hs.32194 [show with all ESTs], Hs.512559 [show with all ESTs]Unigene Representative Sequences: AL834139, AK1280209 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000415566 ENST00000420499 ENST00000442930 ENST00000462148 ENST00000455439
ENST00000487727(uc004bzj.3) ENST00000480829 ENST00000428715 ENST00000302481(uc004bzl.3)
Additional cDNA sequence: AK128020.1 BC146865.1 8 DOTS entries: DT.40222092 DT.40241368 DT.110474 DT.95132814 DT.91848890 DT.99927682 DT.101971774 DT.121156263 1 AceView cDNA sequence: T11491
GeneLoc Exon Structure
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Expression
for HMCN2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HMCN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGAGCCCG
About this image
See HMCN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HMCN2
SOURCE GeneReport for Unigene clusters: Hs.32194 Hs.512559
SABiosciences Custom PCR Arrays for HMCN2
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat HMCN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMCN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMCN2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMCN2 |
Orthologs
for HMCN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HMCN2 gene from 1/12 species (see all 12) About this table
ENSEMBL Gene Tree for HMCN2 (if available)
TreeFam Gene Tree for HMCN2 (if available) |
Paralogs
for HMCN2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HMCN2 gene
- VCAM12 IGSF102 HMCN12 ENSG000002154282 PTK72 MXRA52 HSPG22
18/26 SIMAP similar genes for HMCN2 using alignment to 6 protein entries: HMCN2_HUMAN (see all proteins)
(see all similar genes):LOC392395 FBLN1 PXDN MUSK CRELD1 SDK1
DKFZp762L185 KIAA0992 ROBO3 FGFR3 IGDCC3 NCAM2
PRTG OBSCN LSAMP PXDNL HSPG2 ROBO2
HMCN2 for paralogs About GeneDecksing
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Genomic Variants
for HMCN2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HMCN2 (133028269 - 133278269 bp, first 250kb of HMCN2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HMCN2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HMCN2 |
|
Disorders
/ Diseases
for HMCN2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 HMCN2 for disorders About MalaCards
HMCN2 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: HMCN2 (1 document)
Export disorders for HMCN2 gene to outside databases
|
Publications
for HMCN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HMCN2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HMCN2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. (PubMed id 12388743)1 Whittaker C.A. and Hynes R.O. (2002)
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External Searches for HMCN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing HMCN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HMCN2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HMCN2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HMCN2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for HMCN2 gene:
Search GeneIP for patents involving HMCN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HMCN2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HMCN2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HMCN2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HMCN2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HMCN2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HMCN2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HMCN2 |
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 |  |  |  | |
| | | | Search Tocris compounds for HMCN2 |
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 | | | HMCN2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMCN2 |
|  |  |  | | | | Search ThermoFisher Antibodies for HMCN2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HMCN2 |
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