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Aliases for HMCN2 Gene

Aliases for HMCN2 Gene

  • Hemicentin 2 2 3
  • Hemicentin-2 3

External Ids for HMCN2 Gene

Summaries for HMCN2 Gene

GeneCards Summary for HMCN2 Gene

HMCN2 (Hemicentin 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is LTBP3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMCN2 Gene

Genomics for HMCN2 Gene

Genomic Location for HMCN2 Gene

Start:
130,265,879 bp from pter
End:
130,434,123 bp from pter
Size:
168,245 bases
Orientation:
Plus strand

Genomic View for HMCN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMCN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMCN2 Gene

Regulatory Elements for HMCN2 Gene

Proteins for HMCN2 Gene

  • Protein details for HMCN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NDA2-HMCN2_HUMAN
    Recommended name:
    Hemicentin-2
    Protein Accession:
    Q8NDA2
    Secondary Accessions:
    • Q8N225
    • Q8TCI8

    Protein attributes for HMCN2 Gene

    Size:
    5065 amino acids
    Molecular mass:
    542605 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85069.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04201.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW87931.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for HMCN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HMCN2 Gene

Proteomics data for HMCN2 Gene at MOPED

Post-translational modifications for HMCN2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn329, Asn346, Asn379, Asn478, Asn525, Asn547, Asn674, Asn1024, Asn1223, Asn1309, Asn1507, Asn1533, Asn1641, Asn1900, Asn2000, Asn2079, Asn2085, Asn2243, Asn2281, Asn2361, Asn2435, Asn2468, Asn2507, Asn2572, Asn2654, Asn2858, Asn2952, Asn3396, Asn3526, Asn3541, Asn3683, Asn3687, Asn3772, Asn4068, Asn4270, Asn4421, Asn4567, Asn4810, and Asn5000

Other Protein References for HMCN2 Gene

No data available for DME Specific Peptides for HMCN2 Gene

Domains for HMCN2 Gene

Gene Families for HMCN2 Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • FBLN :Fibulins

UniProtKB/Swiss-Prot:

HMCN2_HUMAN
Domain:
  • Contains 5 EGF-like domains.:
    • Q8NDA2
  • Contains 42 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q8NDA2
  • Contains 1 nidogen G2 beta-barrel domain.:
    • Q8NDA2
  • Contains 1 VWFA domain.:
    • Q8NDA2
genes like me logo Genes that share domains with HMCN2: view

Function for HMCN2 Gene

Gene Ontology (GO) - Molecular Function for HMCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with HMCN2: view

Phenotypes for HMCN2 Gene

GenomeRNAi human phenotypes for HMCN2:
genes like me logo Genes that share phenotypes with HMCN2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HMCN2 Gene

Localization for HMCN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMCN2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMCN2 Gene COMPARTMENTS Subcellular localization image for HMCN2 gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HMCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005604 basement membrane --
GO:0005938 cell cortex --
GO:0030054 cell junction --
genes like me logo Genes that share ontologies with HMCN2: view

Pathways for HMCN2 Gene

SuperPathways for HMCN2 Gene

No Data Available

Interacting Proteins for HMCN2 Gene

Gene Ontology (GO) - Biological Process for HMCN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050896 response to stimulus IEA --
genes like me logo Genes that share ontologies with HMCN2: view

No data available for Pathways by source for HMCN2 Gene

Transcripts for HMCN2 Gene

mRNA/cDNA for HMCN2 Gene

(8) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HMCN2 Gene

Hemicentin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMCN2 Gene

No ASD Table

Relevant External Links for HMCN2 Gene

GeneLoc Exon Structure for
HMCN2
ECgene alternative splicing isoforms for
HMCN2

Expression for HMCN2 Gene

mRNA expression in normal human tissues for HMCN2 Gene

mRNA differential expression in normal tissues according to GTEx for HMCN2 Gene

This gene is overexpressed in Colon - Sigmoid (9.2) and Small Intestine - Terminal Ileum (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HMCN2 Gene

SOURCE GeneReport for Unigene cluster for HMCN2 Gene Hs.32194

genes like me logo Genes that share expressions with HMCN2: view

Orthologs for HMCN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HMCN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMCN2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HMCN2 36
  • 85.64 (n)
  • 83.6 (a)
HMCN2 37
  • 13 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HMCN2 36
  • 85.24 (n)
  • 83.9 (a)
HMCN2 37
  • 13 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmcn2 36
  • 81.39 (n)
  • 81.12 (a)
Hmcn2 16
Hmcn2 37
  • 13 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HMCN2 37
  • 10 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HMCN2 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hmcn2 36
  • 81.12 (n)
  • 80.82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hmcn2 36
  • 57.74 (n)
  • 51.07 (a)
zebrafish
(Danio rerio)
Actinopterygii hmcn2 37
  • 11 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea him-4 37
  • 3 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 21 (a)
OneToMany
Species with no ortholog for HMCN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HMCN2 Gene

ENSEMBL:
Gene Tree for HMCN2 (if available)
TreeFam:
Gene Tree for HMCN2 (if available)

Paralogs for HMCN2 Gene

genes like me logo Genes that share paralogs with HMCN2: view

Variants for HMCN2 Gene

Sequence variations from dbSNP and Humsavar for HMCN2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs13201 -- 130,433,937(+) CCGGG(G/T)AAGCC utr-variant-3-prime
rs867943 -- 130,370,645(+) GGTCC(C/T)ACTGG intron-variant
rs870748 -- 130,289,566(-) acaca(A/G)gaaga intron-variant
rs880072 -- 130,361,698(+) CCCAT(C/T)CCCAT intron-variant
rs883982 -- 130,394,950(-) ATGCA(A/T)CGAGG intron-variant

Relevant External Links for HMCN2 Gene

HapMap Linkage Disequilibrium report
HMCN2

No data available for Structural Variations from Database of Genomic Variants (DGV) for HMCN2 Gene

Disorders for HMCN2 Gene

Relevant External Links for HMCN2

Genetic Association Database (GAD)
HMCN2
Human Genome Epidemiology (HuGE) Navigator
HMCN2
genes like me logo Genes that share disorders with HMCN2: view

No data available for UniProtKB/Swiss-Prot for HMCN2 Gene

Publications for HMCN2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4
  5. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) KAPnig R. … Chanda S.K. (Cell 2008) 3

Products for HMCN2 Gene

Sources for HMCN2 Gene

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