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Aliases for HMCES Gene

Aliases for HMCES Gene

  • 5-Hydroxymethylcytosine (HmC) Binding, ES Cell-Specific 2 3 5
  • ES Cell-Specific 5hmC-Binding Protein 3 4
  • SRAP Domain-Containing Protein 1 3 4
  • Putative Peptidase SRAPD1 3 4
  • C3orf37 3 4
  • SRAPD1 3 4
  • DC12 3 4
  • SOS Response Associated Peptidase Domain Containing 1 2
  • Chromosome 3 Open Reading Frame 37 2
  • UPF0361 Protein C3orf37 3
  • EC 3.4.-.- 4

External Ids for HMCES Gene

Previous HGNC Symbols for HMCES Gene

  • C3orf37

Previous GeneCards Identifiers for HMCES Gene

  • GC03P128998
  • GC03P129074

Summaries for HMCES Gene

GeneCards Summary for HMCES Gene

HMCES (5-Hydroxymethylcytosine (HmC) Binding, ES Cell-Specific) is a Protein Coding gene. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot for HMCES Gene

  • Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMCES Gene

Genomics for HMCES Gene

Regulatory Elements for HMCES Gene

Enhancers for HMCES Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HMCES on UCSC Golden Path with GeneCards custom track

Promoters for HMCES Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HMCES on UCSC Golden Path with GeneCards custom track

Genomic Location for HMCES Gene

Chromosome:
3
Start:
129,278,816 bp from pter
End:
129,306,186 bp from pter
Size:
27,371 bases
Orientation:
Plus strand

Genomic View for HMCES Gene

Genes around HMCES on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMCES Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMCES Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMCES Gene

Proteins for HMCES Gene

  • Protein details for HMCES Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FZ2-HMCES_HUMAN
    Recommended name:
    Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein
    Protein Accession:
    Q96FZ2
    Secondary Accessions:
    • A6NJR9
    • Q96G34
    • Q9NRP3

    Protein attributes for HMCES Gene

    Size:
    354 amino acids
    Molecular mass:
    40575 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF86870.1; Type=Frameshift; Positions=285, 326, 344; Evidence={ECO:0000305};

neXtProt entry for HMCES Gene

Proteomics data for HMCES Gene at MOPED

Post-translational modifications for HMCES Gene

  • Ubiquitination at Lys 44 and Lys 89
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HMCES Gene

Domains & Families for HMCES Gene

Protein Domains for HMCES Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HMCES Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96FZ2

UniProtKB/Swiss-Prot:

HMCES_HUMAN :
  • Belongs to the SOS response-associated peptidase family.
Family:
  • Belongs to the SOS response-associated peptidase family.
genes like me logo Genes that share domains with HMCES: view

No data available for Gene Families for HMCES Gene

Function for HMCES Gene

Molecular function for HMCES Gene

UniProtKB/Swiss-Prot Function:
Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).

Enzyme Numbers (IUBMB) for HMCES Gene

Gene Ontology (GO) - Molecular Function for HMCES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with HMCES: view

Phenotypes for HMCES Gene

genes like me logo Genes that share phenotypes with HMCES: view

Animal Model Products

miRNA for HMCES Gene

miRTarBase miRNAs that target HMCES

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HMCES Gene

Localization for HMCES Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HMCES Gene

Pathways & Interactions for HMCES Gene

SuperPathways for HMCES Gene

No Data Available

Interacting Proteins for HMCES Gene

Gene Ontology (GO) - Biological Process for HMCES Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HMCES Gene

Drugs & Compounds for HMCES Gene

No Compound Related Data Available

Transcripts for HMCES Gene

Alternative Splicing Database (ASD) splice patterns (SP) for HMCES Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - - -
SP2: -
SP3: - -
SP4: - - - - - - -
SP5: - - -
SP6: - -
SP7: - - - - -
SP8:
SP9: - - -

Relevant External Links for HMCES Gene

GeneLoc Exon Structure for
HMCES
ECgene alternative splicing isoforms for
HMCES

Expression for HMCES Gene

mRNA expression in normal human tissues for HMCES Gene

Protein differential expression in normal tissues from HIPED for HMCES Gene

This gene is overexpressed in Testis (22.9), Ovary (9.4), CD8 Tcells (9.1), and Fetal ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMCES Gene



genes like me logo Genes that share expression patterns with HMCES: view

Protein tissue co-expression partners for HMCES Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HMCES Gene

Orthologs for HMCES Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HMCES Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C22H3orf37 35
  • 80.7 (n)
  • 80.23 (a)
HMCES 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C20H3orf37 35
  • 87.35 (n)
  • 88.1 (a)
HMCES 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmces 35
  • 84.85 (n)
  • 84.66 (a)
Hmces 16
Hmces 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C3H3orf37 35
  • 99.44 (n)
  • 99.15 (a)
HMCES 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hmces 35
  • 84.56 (n)
  • 84.09 (a)
oppossum
(Monodelphis domestica)
Mammalia HMCES 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HMCES 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves C12H3ORF37 35
  • 65.54 (n)
  • 62.88 (a)
C12H3ORF37 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HMCES 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hmces 35
  • 64.44 (n)
  • 64.85 (a)
MGC75607 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.5297 35
zebrafish
(Danio rerio)
Actinopterygii hmces 35
  • 58.93 (n)
  • 57.59 (a)
hmces 36
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003544 35
  • 46.62 (n)
  • 40.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11986 35
  • 49.49 (n)
  • 41.02 (a)
CG11986 36
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 24 (a)
OneToOne
Species with no ortholog for HMCES:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HMCES Gene

ENSEMBL:
Gene Tree for HMCES (if available)
TreeFam:
Gene Tree for HMCES (if available)

Paralogs for HMCES Gene

No data available for Paralogs for HMCES Gene

Variants for HMCES Gene

Sequence variations from dbSNP and Humsavar for HMCES Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10712 -- 129,305,196(-) AAAAA(C/G)TGAAA utr-variant-3-prime
rs13255 -- 129,304,962(-) AAAAA(A/G)ACTAC utr-variant-3-prime
rs7430194 -- 129,289,695(+) CTATG(G/T)GTTAc intron-variant
rs7433230 -- 129,278,571(+) CTGAA(A/G)CACGC upstream-variant-2KB
rs7434264 -- 129,283,277(+) ATTGC(A/G)TAATG intron-variant

Variation tolerance for HMCES Gene

Residual Variation Intolerance Score: 25.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.28; 62.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HMCES Gene

HapMap Linkage Disequilibrium report
HMCES

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HMCES Gene

Disorders for HMCES Gene

Relevant External Links for HMCES

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HMCES

No disorders were found for HMCES Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMCES Gene

Publications for HMCES Gene

  1. Novel autoproteolytic and DNA-damage sensing components in the bacterial SOS response and oxidized methylcytosine-induced eukaryotic DNA demethylation systems. (PMID: 23945014) Aravind L. … Iyer L.M. (Biol. Direct 2013) 2 3 4 67
  2. Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. (PMID: 23434322) Spruijt C.G. … Vermeulen M. (Cell 2013) 2 3
  3. Prognostic values of 5-hmC, 5-mC and TET2 in epithelial ovarian cancer. (PMID: 25827305) Zhang L.Y. … Zhang X.C. (Arch. Gynecol. Obstet. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for HMCES Gene

Sources for HMCES Gene

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