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HMCES Gene

protein-coding   GIFtS: 36
GCID: GC03P129074

5-Hydroxymethylcytosine (HmC) Binding, ES Cell-Specific

(Previous name: chromosome 3 open reading frame 37)
(Previous symbol: C3orf37)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
5-Hydroxymethylcytosine (HmC) Binding, ES Cell-Specific1 2     SOS Response Associated Peptidase Domain Containing 11
C3orf371 2 3     Embryonic Stem Cell-Specific 5-Hydroxymethylcytosine-Binding Protein2
Putative Peptidase SRAPD12 3     UPF0361 Protein C3orf372
ES Cell-Specific 5hmC-Binding Protein2 3     DC123
SRAP Domain-Containing Protein 12 3     EC 3.4.-.-3
Chromosome 3 Open Reading Frame 371     SRAPD13

External Ids:    HGNC: 244461   Entrez Gene: 569412   Ensembl: ENSG000001836247   UniProtKB: Q96FZ23   

Export aliases for HMCES gene to outside databases

Previous GC identifer: GC03P128998


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HMCES Gene:
HMCES (5-hydroxymethylcytosine (hmC) binding, ES cell-specific) is a protein-coding gene.

UniProtKB/Swiss-Prot: HMCES_HUMAN, Q96FZ2
Function: Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts
as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are
however required to confirm this prediction (PubMed:23945014)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for HMCES
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HMCES

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMCES


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3   Ensembl cytogenetic band:  3q21.3   HGNC cytogenetic band: 3q21.3

HMCES Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMCES gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P129074:  view genomic region     (about GC identifiers)

Start:
128,997,671 bp from pter      End:
129,025,029 bp from pter
Size:
27,359 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HMCES_HUMAN, Q96FZ2 (See protein sequence)
Recommended Name: Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein  
Size: 354 amino acids; 40575 Da
Sequence caution: Sequence=AAF86870.1; Type=Frameshift; Positions=285, 326, 344;
Secondary accessions: A6NJR9 Q96G34 Q9NRP3

Explore the universe of human proteins at neXtProt for HMCES: NX_Q96FZ2

Explore proteomics data for HMCES at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys44, Lys89
  • Modification sites at PhosphoSitePlus

  • See HMCES Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001006109.1  NP_064572.2  

    ENSEMBL proteins: 
     ENSP00000423132   ENSP00000372955   ENSP00000392966   ENSP00000426276   ENSP00000426215  
     ENSP00000374385   ENSP00000424594   ENSP00000421895  

    HMCES Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for HMCES
    OriGene MassSpec for HMCES
    OriGene Custom Protein Services for HMCES
    GenScript Custom Purified and Recombinant Proteins Services for HMCES
    Novus Biologicals HMCES Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HMCES 

     
    antibodies-online proteins for HMCES (2 products) 

     
    antibodies-online peptides for HMCES

    HMCES Antibody Products:

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    Search for Antibodies for HMCES at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for HMCES
    antibodies-online antibodies for HMCES (23 products) 

    HMCES Assay Products:

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    GenScript Custom Assay Services for HMCES
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for HMCES 
    antibodies-online kits for HMCES (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003738 DUF159

    Graphical View of Domain Structure for InterPro Entry Q96FZ2

    ProtoNet protein and cluster: Q96FZ2

    UniProtKB/Swiss-Prot: HMCES_HUMAN, Q96FZ2
    Similarity: Belongs to the SOS response-associated peptidase family


    Find genes that share domains with HMCES           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HMCES_HUMAN, Q96FZ2
    Function: Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts
    as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are
    however required to confirm this prediction (PubMed:23945014)

         Enzyme Number (IUBMB): EC 3.4.-.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0008233peptidase activity IEA--
         
    Find genes that share ontologies with HMCES           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HMCES:
     Increased cell number in G2M,  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HMCES

    miRNA
    Products:
        
    miRTarBase miRNAs that target HMCES:
    hsa-mir-877-3p (MIRT036989)

    Block miRNA regulation of human, mouse, rat HMCES using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HMCES
    SwitchGear 3'UTR luciferase reporter plasmidHMCES 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HMCES

    Gene Editing
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    Sino Biological Human cDNA Clone for HMCES
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HMCES

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    Browse ESI BIO Cell Lines and PureStem Progenitors for HMCES 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMCES


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HMCES
    Interactions:

        Search GeneGlobe Interaction Network for HMCES

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for HMCES (ENSP000003729554) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO2ENSP000004059654STRING: ENSP00000405965
    UBCENSP000003448184STRING: ENSP00000344818
    ZC3H14ENSP000002510384STRING: ENSP00000251038
    WDR76ENSP000002637954STRING: ENSP00000263795
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----

    Find genes that share ontologies with HMCES           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HMCES



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HMCES gene (2 alternative transcripts): 
    NM_001006109.1  NM_020187.2  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509042 ENST00000383463(uc003elt.3 uc003elu.3) ENST00000417226
    ENST00000510314 ENST00000502878(uc003elv.3 uc003elw.3) ENST00000389735
    ENST00000509551 ENST00000511665
    miRNA
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    Block miRNA regulation of human, mouse, rat HMCES using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HMCES
    SwitchGear 3'UTR luciferase reporter plasmidHMCES 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HMCES
    Predesigned siRNA for gene silencing in human, mouse, rat HMCES
    Clone
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    OriGene clones in human, mouse for HMCES (see all 11)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    Primer
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    OriGene qPCR primer pairs and template standards for HMCES
    OriGene qSTAR qPCR primer pairs in human, mouse for HMCES
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat HMCES
      QuantiTect SYBR Green Assays in human, mouse, rat HMCES
      QuantiFast Probe-based Assays in human, mouse, rat HMCES

    Selected AceView cDNA sequences (see all 424):

    BI964072 BG259212 BU679711 BM051516 BQ229939 BU193095 CB266786 F09551 
    BM666570 AI391614 BM717521 BE644761 BM703711 AA970686 BC010125 BM805601 
    AA740428 BU187972 AW471383 BM826192 BM981960 BE513921 AI362115 T08516 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HMCES (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b
    SP1:              -     -     -     -     -     -                                                               
    SP2:                                            -                                                               
    SP3:                                      -     -                                                               
    SP4:              -     -     -     -     -     -                       -                                       
    SP5:                                -     -     -                                                               


    ECgene alternative splicing isoforms for HMCES

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HMCES expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HMCES Expression
    About this image

    HMCES Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HMCES Protein Expression
        Custom PCR Arrays for HMCES
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMCES

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HMCES gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 8430410A17Rik5
    Hmces1
    RIKEN cDNA 8430410A17 gene5
    5-hydroxymethylcytosine (hmC) binding, ES cell specific1
    84.85(n)1
    84.66(a)1
      6 (39.13 cM)5
    2322101  NM_173737.21  NP_776098.11 
     879139355 
    chicken
    (Gallus gallus)
    Aves C12H3ORF371 chromosome 12 open reading frame, human C3orf37 65.54(n)
    62.88(a)
      416015  NM_001006137.1  NP_001006137.1 
    lizard
    (Anolis carolinensis)
    Reptilia HMCES6
    5-hydroxymethylcytosine (hmC) binding, ES cell-spe...
    62(a)
    1 ↔ 1
    2(164685085-164700999)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.52972 Xenopus laevis transcribed sequence with weak similarity more 73.5(n)    CD360690.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmces1 5-hydroxymethylcytosine (hmC) binding, ES cell-specific 58.93(n)
    57.59(a)
      560402  NM_001099418.1  NP_001092888.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG119861 CG11986 49.49(n)
    41.02(a)
      41083  NM_141605.2  NP_649862.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    Protein of unknown function; may interact with rib...
    24(a)
    1 ↔ 1
    XIII(496343-497449) YMR114C


    ENSEMBL Gene Tree for HMCES (if available)
    TreeFam Gene Tree for HMCES (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HMCES (see all 556)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406586971,2
    C--128997257(+) TTCTT-/CTGACT 2 -- us2k10--------
    rs1915295991,2
    --128997328(+) GAAGTA/GAGGAG 2 -- us2k10--------
    rs1451357981,2
    --128997394(+) GGGAAC/TCTTCC 2 -- us2k10--------
    rs74332301,2
    C,F,A--128997414(+) CTGAAA/GCACGC 2 -- us2k19Minor allele frequency- G:0.33NA WA CSA EA 369
    rs74293881,2
    C,F--128997418(+) AACACG/ACTGGG 2 -- us2k13Minor allele frequency- A:0.35NA WA 122
    rs1167448321,2
    C,F--128997488(+) GAGAAG/ACTTGG 2 -- us2k11Minor allele frequency- A:0.09WA 118
    rs1177373011,2
    C,F--128997608(+) AACCAA/CGGGCC 2 -- us2k11Minor allele frequency- C:0.06EA 120
    rs1834186661,2
    --128997653(+) TGAGGC/GGGGGC 2 -- us2k10--------
    rs1127957051,2
    C,F--128997691(+) CCAAAG/ACGGAG 2 -- ut51 us2k12Minor allele frequency- A:0.10CSA WA 119
    rs1167691111,2
    C,F--128997702(+) CGGAGC/GGGGGG 2 -- ut51 us2k12Minor allele frequency- G:0.26WA EA 238

    HapMap Linkage Disequilibrium report for HMCES (128997671 - 129025029 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HMCES: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HMCES
    DNA2.0 Custom Variant and Variant Library Synthesis for HMCES

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HMCES gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with HMCES)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel autoproteolytic and DNA-damage sensing components in the bacterial SOS response and oxidized methylcytosine-induced eukaryotic DNA demethylation systems. (PubMed id 23945014)1, 2, 3 Aravind L....Iyer L.M. (Biol. Direct 2013)
    2. Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. (PubMed id 23434322)1, 3 Spruijt C.G....Vermeulen M. (Cell 2013)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56941 HGNC: 24446 AceView: DC12 Ensembl:ENSG00000183624 euGenes: HUgn56941
    ECgene: HMCES H-InvDB: HMCES

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HMCES Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HMCES gene:
    Search GeneIP for patents involving HMCES

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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