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Aliases for HMCES Gene

Aliases for HMCES Gene

  • 5-Hydroxymethylcytosine (HmC) Binding, ES Cell-Specific 2 3
  • ES Cell-Specific 5hmC-Binding Protein 3 4
  • SRAP Domain-Containing Protein 1 3 4
  • Putative Peptidase SRAPD1 3 4
  • C3orf37 3 4
  • SRAPD1 3 4
  • DC12 3 4
  • Embryonic Stem Cell-Specific 5-Hydroxymethylcytosine-Binding Protein 3
  • SOS Response Associated Peptidase Domain Containing 1 2
  • Chromosome 3 Open Reading Frame 37 2
  • UPF0361 Protein C3orf37 3
  • EC 3.4.-.- 4

External Ids for HMCES Gene

Previous Symbols for HMCES Gene

  • C3orf37

Summaries for HMCES Gene

GeneCards Summary for HMCES Gene

HMCES (5-Hydroxymethylcytosine (HmC) Binding, ES Cell-Specific) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HMCES Gene

  • Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMCES Gene

Genomics for HMCES Gene

Genomic Location for HMCES Gene

129,278,828 bp from pter
129,306,186 bp from pter
27,359 bases
Plus strand

Genomic View for HMCES Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMCES Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMCES Gene

No data available for Regulatory Elements for HMCES Gene

Proteins for HMCES Gene

  • Protein details for HMCES Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein
    Protein Accession:
    Secondary Accessions:
    • A6NJR9
    • Q96G34
    • Q9NRP3

    Protein attributes for HMCES Gene

    354 amino acids
    Molecular mass:
    40575 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF86870.1; Type=Frameshift; Positions=285, 326, 344; Evidence={ECO:0000305};

neXtProt entry for HMCES Gene

Proteomics data for HMCES Gene at MOPED

Post-translational modifications for HMCES Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys44 and Lys89

No data available for DME Specific Peptides for HMCES Gene

Domains for HMCES Gene

Protein Domains for HMCES Gene



  • Belongs to the SOS response-associated peptidase family.:
    • Q96FZ2
genes like me logo Genes that share domains with HMCES: view

No data available for Gene Families for HMCES Gene

Function for HMCES Gene

Molecular function for HMCES Gene

UniProtKB/Swiss-Prot Function: Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).

Enzyme Numbers (IUBMB) for HMCES Gene

Gene Ontology (GO) - Molecular Function for HMCES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with HMCES: view

Phenotypes for HMCES Gene

GenomeRNAi human phenotypes for HMCES:
genes like me logo Genes that share phenotypes with HMCES: view

miRNA for HMCES Gene

miRTarBase miRNAs that target HMCES

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for HMCES Gene

Localization for HMCES Gene

No data available for Gene Ontology (GO) - Cellular Components for HMCES Gene

Pathways for HMCES Gene

SuperPathways for HMCES Gene

No Data Available

Interacting Proteins for HMCES Gene

Gene Ontology (GO) - Biological Process for HMCES Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with HMCES: view

No data available for Pathways by source for HMCES Gene

Transcripts for HMCES Gene

Alternative Splicing Database (ASD) splice patterns (SP) for HMCES Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b
SP1: - - - - - -
SP2: -
SP3: - -
SP4: - - - - - - -
SP5: - - -
SP6: - -
SP7: - - - - -
SP9: - - -

Relevant External Links for HMCES Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HMCES Gene

mRNA expression in normal human tissues for HMCES Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMCES Gene

genes like me logo Genes that share expressions with HMCES: view

Orthologs for HMCES Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HMCES Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C3H3orf37 36
  • 99.44 (n)
  • 99.15 (a)
  • 99 (a)
(Bos Taurus)
Mammalia C22H3orf37 36
  • 80.7 (n)
  • 80.23 (a)
  • 81 (a)
(Canis familiaris)
Mammalia C20H3orf37 36
  • 87.35 (n)
  • 88.1 (a)
  • 87 (a)
(Mus musculus)
Mammalia 8430410A17Rik 16
Hmces 36
  • 84.85 (n)
  • 84.66 (a)
Hmces 37
  • 84 (a)
(Monodelphis domestica)
Mammalia HMCES 37
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia HMCES 37
  • 79 (a)
(Rattus norvegicus)
Mammalia Hmces 36
  • 84.56 (n)
  • 84.09 (a)
(Gallus gallus)
Aves C12H3ORF37 36
  • 65.54 (n)
  • 62.88 (a)
C12H3ORF37 37
  • 61 (a)
(Anolis carolinensis)
Reptilia HMCES 37
  • 62 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5297 36
tropical clawed frog
(Silurana tropicalis)
Amphibia hmces 36
  • 64.44 (n)
  • 64.85 (a)
MGC75607 36
(Danio rerio)
Actinopterygii hmces 36
  • 58.93 (n)
  • 57.59 (a)
hmces 37
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003544 36
  • 46.62 (n)
  • 40.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11986 36
  • 49.49 (n)
  • 41.02 (a)
CG11986 37
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 24 (a)
Species with no ortholog for HMCES:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HMCES Gene

Gene Tree for HMCES (if available)
Gene Tree for HMCES (if available)

Paralogs for HMCES Gene

No data available for Paralogs for HMCES Gene

Variants for HMCES Gene

Sequence variations from dbSNP and Humsavar for HMCES Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs10712 -- 129,305,196(-) AAAAA(C/G)TGAAA utr-variant-3-prime
rs13255 -- 129,304,962(-) AAAAA(A/G)ACTAC utr-variant-3-prime
rs4075182 -- 129,289,460(+) AGATA(C/T)AAGCC intron-variant
rs6439165 -- 129,281,453(+) tggga(A/G)gccaa intron-variant
rs6439166 -- 129,281,464(+) gacgg(C/G)tggac intron-variant

Relevant External Links for HMCES Gene

HapMap Linkage Disequilibrium report

No data available for Structural Variations from Database of Genomic Variants (DGV) for HMCES Gene

Disorders for HMCES Gene

No disorders were found for HMCES Gene.

No data available for UniProtKB/Swiss-Prot for HMCES Gene

Publications for HMCES Gene

  1. Novel autoproteolytic and DNA-damage sensing components in the bacterial SOS response and oxidized methylcytosine-induced eukaryotic DNA demethylation systems. (PMID: 23945014) Aravind L. … Iyer L.M. (Biol. Direct 2013) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. (PMID: 23434322) Spruijt C.G. … Vermeulen M. (Cell 2013) 2 3
  4. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PMID: 23940030) Teixeira F.R. … Gomes M.D. (J. Biol. Chem. 2013) 3
  5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3

Products for HMCES Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HMCES
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HMCES
    • Block miRNA regulation of HMCES using miScript Target Protectors

    Sources for HMCES Gene

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