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HMBOX1 Gene

protein-coding   GIFtS: 49
GCID: GC08P028805

Homeobox Containing 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox Containing 11 2     PBHNF2
Homeobox Telomere-Binding Protein 11 2     Homeobox-Containing Protein 12
HNF1LA2     Homeobox-Containing Protein PBHNF2
HOT12     

External Ids:    HGNC: 261371   Entrez Gene: 796182   Ensembl: ENSG000001474217   UniProtKB: Q6NT763   

Export aliases for HMBOX1 gene to outside databases

Previous GC identifer: GC08P027293


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HMBOX1 Gene:
HMBOX1 (homeobox containing 1) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: HMBX1_HUMAN, Q6NT76
Function: Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as
a transcriptional repressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HMBOX1 gene promoter:
         AREB6   FOXF2   FOXJ2 (long isoform)   FOXJ2   HNF-3beta   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HMBOX1 promoter sequence
   Search Chromatin IP Primers for HMBOX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HMBOX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.1   Ensembl cytogenetic band:  8p21.1   HGNC cytogenetic band: 8p12

HMBOX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HMBOX1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P028805:  view genomic region     (about GC identifiers)

Start:
28,747,911 bp from pter      End:
28,922,281 bp from pter
Size:
174,371 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HMBX1_HUMAN, Q6NT76 (See protein sequence)
Recommended Name: Homeobox-containing protein 1  
Size: 420 amino acids; 47278 Da
Sequence caution: Sequence=BAB15099.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
2 PDB 3D structures from and Proteopedia for HMBOX1:
2CUF (3D)        4J19 (3D)    
Secondary accessions: A4K385 A8K3R8 B4DHY5 D3DSU0 Q3Y6P1 Q96GS5 Q9H701
Alternative splicing: 5 isoforms:  Q6NT76-1   Q6NT76-2   Q6NT76-3   Q6NT76-4   Q6NT76-5   

Explore the universe of human proteins at neXtProt for HMBOX1: NX_Q6NT76

Explore proteomics data for HMBOX1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HMBOX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129198.1  NP_078843.2  

    ENSEMBL proteins: 
     ENSP00000287701   ENSP00000429767   ENSP00000453211   ENSP00000452827   ENSP00000453185  
     ENSP00000380516   ENSP00000430059   ENSP00000430238   ENSP00000475196   ENSP00000430110  
     ENSP00000430222   ENSP00000429854   ENSP00000401769   ENSP00000384261  

    HMBOX1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for HMBOX1

     
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    Search eBioscience for ELISAs for HMBOX1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HNF: Homeoboxes / HNF class

    4 InterPro protein domains:
     IPR010982 Lambda_DNA-bd_dom
     IPR006899 HNF-1_N
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q6NT76

    ProtoNet protein and cluster: Q6NT76

    UniProtKB/Swiss-Prot: HMBX1_HUMAN, Q6NT76
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with HMBOX1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HMBX1_HUMAN, Q6NT76
    Function: Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as
    a transcriptional repressor

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with HMBOX1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HMBOX1:
     Synthetic lethal with Ras 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Hmbox1):
     cellular 

    Find genes that share phenotypes with HMBOX1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HMBOX1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HMBOX1
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    miRNA
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    miRTarBase miRNAs that target HMBOX1:
    hsa-mir-335-5p (MIRT016719), hsa-mir-30c-1-3p (MIRT006274)

    Block miRNA regulation of human, mouse, rat HMBOX1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HMBOX1 (see all 74):
    hsa-miR-548j hsa-miR-520e hsa-miR-106a hsa-miR-15a hsa-miR-93 hsa-miR-548a-5p hsa-miR-556-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidHMBOX1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HMBOX1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMBOX1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HMBX1_HUMAN, Q6NT76: Nucleus. Cytoplasm. Note=Predominantly detected in cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with HMBOX1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HMBOX1
    Interactions:

        Search GeneGlobe Interaction Network for HMBOX1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for HMBOX1 (Q6NT761 ENSP000002877014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DKC1O608321EBI-2549423,EBI-713091
    XRCC6P129561EBI-2549423,EBI-353208
    SUMO2ENSP000004059654STRING: ENSP00000405965
    ENTPD2ENSP000003472134STRING: ENSP00000347213
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0045892negative regulation of transcription, DNA-templated IDA19757162
    GO:0045893positive regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with HMBOX1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HMBOX1 (HMBX1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HMBOX1 gene (2 alternative transcripts): 
    NM_001135726.1  NM_024567.3  

    Unigene Cluster for HMBOX1:

    Homeobox containing 1
    Hs.591836  [show with all ESTs]
    Unigene Representative Sequence: NM_024567
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000287701(uc003xhd.4 uc010lve.3 uc003xhf.3) ENST00000519662
    ENST00000558662 ENST00000523613(uc010lvd.3) ENST00000560599 ENST00000397358(uc003xhe.3)
    ENST00000560357 ENST00000519047 ENST00000521516 ENST00000560269 ENST00000355231
    ENST00000524238 ENST00000518080 ENST00000517386 ENST00000522468 ENST00000561377
    ENST00000444075(uc011lay.2 uc003xhg.3) ENST00000403668
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HMBOX1 (see all 74):
    hsa-miR-548j hsa-miR-520e hsa-miR-106a hsa-miR-15a hsa-miR-93 hsa-miR-548a-5p hsa-miR-556-3p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidHMBOX1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HMBOX1
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    GenScript: all cDNA clones in your preferred vector (see all 2): HMBOX1 (NM_024567)
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    OriGene qPCR primer pairs and template standards for HMBOX1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HMBOX1
      QuantiTect SYBR Green Assays in human, mouse, rat HMBOX1
      QuantiFast Probe-based Assays in human, mouse, rat HMBOX1

    Additional mRNA sequence: 

    AK025269.1 AK290683.1 AK295320.1 AK310959.1 AL832296.1 AY522342.1 BC009259.2 BC069242.1 
    DQ153248.1 

    10 DOTS entries:

    DT.121492024  DT.85105240  DT.415082  DT.100752145  DT.95163032  DT.121491970  DT.115823  DT.121491998 
    DT.121492014  DT.86835960 

    Selected AceView cDNA sequences (see all 294):

    AA694256 AA333212 AI553987 BX487744 BU682805 AW169381 AA262712 BC069242 
    AI184805 AA668984 BE672504 BX089752 BM351924 BQ014330 AW194481 BX353564 
    BQ071346 AA262188 BF369137 AA886446 AI378922 AL705656 CR605519 BU630670 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HMBOX1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:                                                              -     -     -     -     -                     
    SP2:                                                                                                            
    SP3:                                                              -     -     -     -     -                     
    SP4:                                                              -     -     -                                 
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for HMBOX1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HMBOX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTAAAAACA
    HMBOX1 Expression
    About this image

    HMBOX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HMBOX1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591836

    UniProtKB/Swiss-Prot: HMBX1_HUMAN, Q6NT76
    Tissue specificity: Ubiquitous. Detected in pancreas, brain, spleen, placenta, prostate, thymus, liver, heart,
    bone marrow, skeletal muscle, stomach, uterus, testis, kidney, ovary, and colon

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HMBOX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HMBOX1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hmbox11 , 5 homeobox containing 11, 5 92.04(n)1
    99.05(a)1
      14 (33.79 cM)5
    2191501  NM_177338.51  NP_796312.21 
     648116015 
    chicken
    (Gallus gallus)
    Aves HMBOX11 homeobox containing 1 86.4(n)
    96.66(a)
      422024  NM_001277716.1  NP_001264645.1 
    lizard
    (Anolis carolinensis)
    Reptilia HMBOX16
    homeobox containing 1
    89(a)
    1 ↔ 1
    GL343333.1(1204826-1310041)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.212822 Xenopus laevis transcribed sequence with moderate similarity more 83.41(n)    BJ048505.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hmbox1b1 homeobox containing 1 b 70.45(n)
    79.75(a)
      100317353  XM_005173821.1  XP_005173878.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hmbx-11 hmbx-1 41.38(n)
    31.58(a)
      171679  NM_058402.5  NP_490803.1 


    ENSEMBL Gene Tree for HMBOX1 (if available)
    TreeFam Gene Tree for HMBOX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HMBOX1 gene
    1 SIMAP similar gene for HMBOX1 using alignment to 8 protein entries:     HMBX1_HUMAN (see all proteins):
    HNF1A

    Find genes that share paralogs with HMBOX1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HMBOX1 (see all 2543)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815854561,2
    --28749887(+) AGTTTC/TTAATA 2 -- int10--------
    rs614521861,2
    C--28749953(+) CTTCAA/GTAATC 2 -- int13Minor allele frequency- G:0.03NA EA 242
    rs1497328811,2
    --28749985(+) TGTAAC/TGGATT 2 -- int10--------
    rs1452187831,2
    C--28750081(+) CACCTA/GTCATC 2 -- int10--------
    rs1491355161,2
    --28750250(+) GACCTA/GAATAG 2 -- int10--------
    rs1433061451,2
    --28750418(+) CCTACA/GTAACT 2 -- int10--------
    rs9833651,2
    C,F,O,A,H--28750429(-) CTCCGG/TTAAGT 2 -- int121Minor allele frequency- T:0.39NA NS EA WA 1334
    rs1866501101,2
    --28750432(+) TAACGA/GAGTGT 2 -- int10--------
    rs1903678931,2
    --28750484(+) TTTTTA/TAAAAA 2 -- int10--------
    rs1818235831,2
    --28750744(+) TAAGTA/GCTGGG 2 -- int10--------

    HapMap Linkage Disequilibrium report for HMBOX1 (28747911 - 28922281 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HMBOX1 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661011CNV Deletion23128226
    esv2666663CNV Deletion23128226
    esv2675311CNV Deletion23128226
    esv2736813CNV Deletion23290073
    esv2736811CNV Deletion23290073
    esv2736814CNV Deletion23290073
    esv2676816CNV Deletion23128226
    esv2736812CNV Deletion23290073
    esv2736815CNV Deletion23290073
    nsv398424CNV Insertion16902084

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with HMBOX1           About GenesLikeMe

    Genetic Association Database (GAD): HMBOX1
    Human Genome Epidemiology (HuGE) Navigator: HMBOX1 (1 document)

    Export disorders for HMBOX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HMBOX1 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with HMBOX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and functional analysis of human HMBOX1, a homeobox containing protein with transcriptional repressor activity. (PubMed id 16825764)1, 2, 3 Chen S.... Yu L. (Cytogenet. Genome Res. 2006)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Characterization of a novel human HMBOX1 splicing variant lacking the homeodomain and with attenuated transcription repressor activity. (PubMed id 19757162)1, 2 Zhang M.... Yu L. (Mol. Biol. Rep. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. (PubMed id 23685356)1 Kappei D....Buchholz F. (EMBO J. 2013)
    7. miR-30c-1* promotes natural killer cell cytotoxicity against human hepatoma cells by targeting the transcription factor HMBOX1. (PubMed id 22320217)1 Gong J....Chen L. (Cancer Sci. 2012)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    9. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    10. HMBOX1 negatively regulates NK cell functions by suppressing the NKG2D/DAP10 signaling pathway. (PubMed id 21706044)1 Wu L....Zhang J. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79618 HGNC: 26137 AceView: FLJ21616 Ensembl:ENSG00000147421 euGenes: HUgn79618
    ECgene: HMBOX1 H-InvDB: HMBOX1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HMBOX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HMBOX1 gene:
    Search GeneIP for patents involving HMBOX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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