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HLX Gene

protein-coding   GIFtS: 56
GCID: GC01P221052

H2.0-Like Homeobox

(Previous names: H2.0 (Drosophila)-like homeo box 1, H2.0-like homeobox 1...)
(Previous symbol: HLX1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
H2.0-Like Homeobox1 2     H2.0-Like Homeobox 1 (Drosophila)1
HLX11 2 3 5     HB242
H2.0-Like Homeobox 11 2     H2.0-Like Homeo Box 12
Homeobox Protein HB242 3     H2.0-Like Homeo Box-12
Homeobox Protein HLX12 3     H2.0-Like Homeobox Protein2
H2.0 (Drosophila)-Like Homeo Box 11     

External Ids:    HGNC: 49781   Entrez Gene: 31422   Ensembl: ENSG000001366307   OMIM: 1429955   UniProtKB: Q147743   

Export aliases for HLX gene to outside databases

Previous GC identifers: GC01P219120 GC01P191727


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HLX Gene:
HLX (H2.0-like homeobox) is a protein-coding gene. Diseases associated with HLX include fryns syndrome, and tonsillitis. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DBX2.

UniProtKB/Swiss-Prot: HLX_HUMAN, Q14774
Function: Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance
of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity)

Gene Wiki entry for HLX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the HLX gene promoter:
         E2F-3a   Sox5   STAT1   E2F-1   E2F   E2F-2   IRF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLX promoter sequence
   Search Chromatin IP Primers for HLX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41

HLX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLX gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P221052:  view genomic region     (about GC identifiers)

Start:
221,051,699 bp from pter      End:
221,058,401 bp from pter
Size:
6,703 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HLX_HUMAN, Q14774 (See protein sequence)
Recommended Name: H2.0-like homeobox protein  
Size: 488 amino acids; 50789 Da
Sequence caution: Sequence=BAD92049.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAD92049.1; Type=Frameshift; Positions=198, 259, 321; Sequence=M60721; Type=Frameshift; Positions=69,
115, 152, 167;
Secondary accessions: B2R8A8 Q15988 Q59HE7 Q9NZ75

Explore the universe of human proteins at neXtProt for HLX: NX_Q14774

Explore proteomics data for HLX at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys175
  • Modification sites at PhosphoSitePlus

  • See HLX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_068777.1  
    ENSEMBL proteins: 
     ENSP00000355870   ENSP00000408248   ENSP00000449882  

    HLX Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HLX
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HLX
    GenScript Custom Purified and Recombinant Proteins Services for HLX
    Novus Biologicals HLX Proteins
    Novus Biologicals HLX Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HLX

    HLX Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HLX
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HLX
    OriGene Custom Antibody Services for HLX
    Novus Biologicals HLX Antibodies
    Abcam antibodies for HLX
    Cloud-Clone Corp. Antibodies for HLX
    ThermoFisher Antibodies for HLX
    LSBio Antibodies in human, mouse, rat for HLX

    HLX Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HLX
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HLX
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HLX
    Cloud-Clone Corp. CLIAs for HLX


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NKL: Homeoboxes / ANTP class : NKL subclass

    5 InterPro protein domains:
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q14774

    ProtoNet protein and cluster: Q14774

    1 Blocks protein domain: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: HLX_HUMAN, Q14774
    Similarity: Belongs to the H2.0 homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    HLX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HLX_HUMAN, Q14774
    Function: Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance
    of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0043565sequence-specific DNA binding IDA9073066
         
    HLX for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hlx):
     digestive/alimentary  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     integument  liver/biliary system  mortality/aging  muscle  nervous system 
     respiratory system 

    HLX for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hlxtm1Rph for HLX

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HLX
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HLX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HLX
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HLX

    miRNA
    Products:
        
    miRTarBase miRNAs that target HLX:
    hsa-mir-1260b (MIRT052679)

    Block miRNA regulation of human, mouse, rat HLX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HLX (see all 10):
    hsa-miR-30c hsa-miR-520d-5p hsa-miR-128 hsa-miR-3681* hsa-miR-30d hsa-miR-30a hsa-miR-30b hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidHLX 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HLX
    Predesigned siRNA for gene silencing in human, mouse, rat HLX

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HLX

    Clone
    Products:
         
    OriGene clones in human, mouse for HLX (see all 6)
    OriGene ORF clones in mouse, rat for HLX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLX (NM_021958)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLX

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HLX
    Browse ESI BIO Cell Lines and PureStem Progenitors for HLX 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HLX_HUMAN, Q14774: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    HLX for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HLX About    
    See pathways by source

    SuperPathContained pathways About
    1IL12-mediated signaling events
    IL12-mediated signaling events0.33


    1 BioSystems Pathway for HLX
        IL12-mediated signaling events


        Pathway & Disease-focused RT2 Profiler PCR Array including HLX: 
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HLX

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for HLX (Q147741 ENSP000003558704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUZ12Q150221EBI-6678255,EBI-1264675
    STAT4ENSP000003512554STRING: ENSP00000351255
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007275multicellular organismal development TAS8094082
    GO:0007519skeletal muscle tissue development IEA--

    HLX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HLX



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HLX gene: 
    NM_021958.3  

    Unigene Cluster for HLX:

    H2.0-like homeobox
    Hs.74870  [show with all ESTs]
    Unigene Representative Sequence: NM_021958
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366903(uc001hmv.4) ENST00000427693 ENST00000549319
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HLX using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HLX (see all 10):
    hsa-miR-30c hsa-miR-520d-5p hsa-miR-128 hsa-miR-3681* hsa-miR-30d hsa-miR-30a hsa-miR-30b hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidHLX 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HLX
    Predesigned siRNA for gene silencing in human, mouse, rat HLX
    Clone
    Products:
         
    OriGene clones in human, mouse for HLX (see all 6)
    OriGene ORF clones in mouse, rat for HLX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLX (NM_021958)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLX
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HLX
    OriGene qSTAR qPCR primer pairs in human, mouse for HLX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HLX
      QuantiTect SYBR Green Assays in human, mouse, rat HLX
      QuantiFast Probe-based Assays in human, mouse, rat HLX

    Additional mRNA sequence: 

    AK056326.1 AK127923.1 AK313298.1 BC007294.1 BC033808.1 M60721.1 

    2 DOTS entries:

    DT.410090  DT.95295511 

    Selected AceView cDNA sequences (see all 66):

    BQ020771 BU680518 CA436659 BC033808 BM913402 CR591992 BQ001899 BM972728 
    BQ019098 NM_021958 BE257965 BM542542 BG389919 AK127923 BG390199 BI909283 
    BC007294 BM555802 CD673278 AA640091 BM557295 BM561598 BM462970 AL578176 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HLX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTGGGTTT
    HLX Expression
    About this image


    HLX expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Fetal Hepatic Stellate Cells Sinusoids
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Mesoderm (Gastrulation Derivatives)
             Septum Transversum Mesenchyme Cells Septum Transversum
    HLX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HLX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.74870

    UniProtKB/Swiss-Prot: HLX_HUMAN, Q14774
    Tissue specificity: Low level in normal B and T-cells, high level in activated lymphocytes and monocytes. Also
    found in thymus, tonsil, bone marrow, developing vessels, and fetal brain

        Pathway & Disease-focused RT2 Profiler PCR Array including HLX: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HLX
    OriGene qSTAR qPCR primer pairs in human, mouse for HLX
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HLX
    QuantiTect SYBR Green Assays in human, mouse, rat HLX
    QuantiFast Probe-based Assays in human, mouse, rat HLX
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HLX gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hlx1 , 5 H2.0-like homeobox1, 5 84.31(n)1
    87.82(a)1
      1 (88.97 cM)5
    152841  NM_008250.21  NP_032276.11 
     1847271405 
    chicken
    (Gallus gallus)
    Aves HLX6
    H2.0-like homeobox
    66(a)
    1 ↔ 1
    3(17936724-17938913)
    lizard
    (Anolis carolinensis)
    Reptilia HLX6
    H2.0-like homeobox
    67(a)
    1 ↔ 1
    1(243672632-243682671)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hlx1 H2.0-like homeobox 67.86(n)
    68.68(a)
      100488508  XM_002936014.2  XP_002936060.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hlx11 H2.0-like homeo box 1 (Drosophila) 65.51(n)
    69.5(a)
      327096  NM_212701.1  NP_997866.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta H2.06
    Homeodomain protein 2.0
    26(a)
    1 ↔ 1
    2L(6013057-6019398)


    ENSEMBL Gene Tree for HLX (if available)
    TreeFam Gene Tree for HLX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HLX gene
    DBX22  DBX12  HHEX2  
    Selected SIMAP similar genes for HLX using alignment to 3 protein entries:     HLX_HUMAN (see all proteins) (see all similar genes):
    NKX2-5    EMX1    BARHL2    HOXA3    NKX2-4    BARHL1
    HOXB3    NKX2-6    DLX1    GBX2    NKX6-1    BARX2
    MNX1    NKX2-3    homeobox gene    CDX1    LBX1    BARX1

    HLX for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HLX (see all 230)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1398713581,2
    C--221050832(+) TCTTAA/TGAGAG 1 -- us2k10--------
    rs1421347131,2
    --221050972(+) ACTAGA/GAAGCA 1 -- us2k10--------
    rs797458381,2
    F--221051052(+) TTGCCC/TATGTT 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs1511682171,2
    --221051076(+) CTTTGC/TCTTCA 1 -- us2k10--------
    rs38404401,2
    C--221051334(-) GACTT-/TCTCCT 1 -- us2k10--------
    rs763137791,2
    F--221051455(+) TTCTGG/CGTTTA 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs764250631,2
    F--221051497(+) TAAAAA/CTGTCA 1 -- us2k11Minor allele frequency- C:0.12WA 118
    rs1817164961,2
    --221051532(+) ATTAGG/TGCAAT 1 -- us2k10--------
    rs413690481,2
    C,F--221051566(+) TCATTA/GTTCGT 1 -- us2k13Minor allele frequency- G:0.13NA CSA 124
    rs1403273591,2
    --221051703(+) TATGTC/TGATGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HLX (221051699 - 221058401 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HLX:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819685CNV Gain19587683

    Human Gene Mutation Database (HGMD): HLX
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HLX
    DNA2.0 Custom Variant and Variant Library Synthesis for HLX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142995    OMIM disorders: --

    16 diseases for HLX:    
    About MalaCards
    fryns syndrome    tonsillitis    congenital diaphragmatic hernia    graves' disease
    acute myeloid leukemia    acute leukemia    myeloid leukemia    asthma
    leukemia    atherosclerosis    obesity    cerebritis
    thyroiditis    hepatitis    prostatitis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for HLX:
    Congenital diaphragmatic hernia

    HLX for disorders           About GeneDecksing

    Genetic Association Database (GAD): HLX
    Human Genome Epidemiology (HuGE) Navigator: HLX (3 documents)

    Export disorders for HLX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HLX gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with HLX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a human homeobox gene that resembles a diverged Drosophila homeobox gene and is expressed in activated lymphocytes. (PubMed id 1676597)1, 2, 3, 9 Deguchi Y....Kehrl J.H. (New Biol. 1991)
    2. Genomic structure, promoter sequence, and revised translation of human homeobox gene HLX1. (PubMed id 7806220)1, 2, 3 Kennedy M.A.... Morris C.M. (Genomics 1994)
    3. Linkage localization of TGFB2 and the human homeobox gene HLX1 to chromosome 1q. (PubMed id 8095486)1, 2, 9 Nishimura D.Y.... Murray J.C. (Genomics 1993)
    4. TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants. (PubMed id 19362357)1, 4 Suttner K....Kabesch M. (J. Allergy Clin. Immunol. 2009)
    5. HLX1 gene variants influence the development of childhood asthma. (PubMed id 19038437)1, 4 Suttner K....Kabesch M. (J. Allergy Clin. Immunol. 2009)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. HLX in AML: novel prognostic and therapeutic target. (PubMed id 23888188)1 Pandolfi A. and Steidl U. (Oncotarget 2012)
    8. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    9. H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia. (PubMed id 22897850)1 Kawahara M....Steidl U. (Cancer Cell 2012)
    10. TBX21 and HLX1 polymorphisms influence cytokine secretion at birth. (PubMed id 22303482)1 Casaca V.I....Schaub B. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3142 HGNC: 4978 AceView: HLX1 Ensembl:ENSG00000136630 euGenes: HUgn3142
    ECgene: HLX H-InvDB: HLX

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HLX Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HLX gene:
    Search GeneIP for patents involving HLX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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