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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLX Gene

protein-coding   GIFtS: 54
GCID: GC01P221052

H2.0-like homeobox

(Previous names: H2.0 (Drosophila)-like homeo box 1, H2.0-like homeobox...)
(Previous symbol: HLX1)
 Explore 10 diseases affiliated with
HLX via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HLX    

Aliases
for HLX gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
H2.0-Like Homeobox1 2     H2.0 (Drosophila)-Like Homeo Box 11
HLX11 2 3 5     H2.0-Like Homeobox 1 (Drosophila)1
HB241 2     H2.0-Like Homeo Box 12
H2.0-Like Homeobox 11 2     H2.0-Like Homeo Box-12
Homeobox Protein HB242 3     H2.0-Like Homeobox Protein2
Homeobox Protein HLX12 3     

External Ids:    HGNC: 49781   Entrez Gene: 31422   Ensembl: ENSG000001366307   OMIM: 1429955   UniProtKB: Q147743   

Export aliases for HLX gene to outside databases

Previous GC identifers: GC01P219120 GC01P191727


Summaries
for HLX gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: HLX_HUMAN, Q14774
Function: Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of
Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity)

Gene Wiki entry for HLX


Genomic Views
for HLX gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLX gene promoter:
         E2F-3a   Sox5   STAT1   E2F-1   E2F   E2F-2   IRF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HLX promoter sequence
   Search SABiosciences Chromatin IP Primers for HLX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41

HLX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLX gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P221052:  view genomic region     (about GC identifiers)

Start:
 221,051,699 bp from pter      End:
 221,059,124 bp from pter
Size:
 7,426 bases      Orientation:
 plus strand

Proteins
for HLX gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HLX_HUMAN, Q14774 (See protein sequence)
Recommended Name: H2.0-like homeobox protein  
Size: 488 amino acids; 50789 Da
Subcellular location: Nucleus (Potential)
Sequence caution: Sequence=BAD92049.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAD92049.1; Type=Frameshift; Positions=198, 259, 321; Sequence=M60721; Type=Frameshift; Positions=69, 115,
152, 167;
Secondary accessions: B2R8A8 Q15988 Q59HE7 Q9NZ75

Explore the universe of human proteins at neXtProt for HLX: NX_Q14774

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14774

    • HLX Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_068777.1  
    ENSEMBL proteins: 
     ENSP00000355870   ENSP00000408248   ENSP00000449882  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: HLX
    OriGene Custom Protein Services for HLX 
    GenScript Custom Purified and Recombinant Proteins Services for HLX
    Novus Biologicals HLX Proteins
    Novus Biologicals HLX Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HLX

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    HLX for ontologies           About GeneDecksing



    HLX Antibody Products: 
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    Uscn Antibodies for HLX
    ThermoFisher Antibodies for HLX

    Assay Products for HLX: 
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    GenScript Custom Assay Services for HLX
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HLX

    Protein Domains /
    Families
    for HLX gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HLX for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q14774

    ProtoNet protein and cluster: Q14774

    1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

    UniProtKB/Swiss-Prot: HLX_HUMAN, Q14774
    Similarity: Belongs to the H2.0 homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for HLX gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HLX_HUMAN, Q14774
    Function: Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of
    Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: HLX
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLX
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate HLX (see all 10):
    hsa-miR-30c hsa-miR-520d-5p hsa-miR-128 hsa-miR-3681* hsa-miR-30d hsa-miR-30a hsa-miR-30b hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmid: HLX 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLX (see all 4)
    OriGene shRNA RFP: HLX
    OriGene siRNA: HLX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLX

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HLX

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLX (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLX
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HLX (NM_021958)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLX 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HLX
    Search LifeMap BioReagents cell lines for HLX

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLX

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IDA9073066


    HLX for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Hlxtm1Rph for HLX
         11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hlx):
     digestive/alimentary  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
     integument  liver/biliary system  mortality/aging  muscle  nervous system 
     respiratory system 

    HLX for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HLX gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune response IL-12-induced IFN-gamma production
    		IL12-mediated signaling events0.33


    1 BioSystems Pathway for HLX 
        IL12-mediated signaling events


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HLX

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for HLX (ENSP000003558704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STAT4ENSP000003512554STRING: ENSP00000351255
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007275multicellular organismal development TAS8094082
    GO:0007519skeletal muscle tissue development IEA--
    GO:0008284positive regulation of cell proliferation IEA--


    HLX for ontologies           About GeneDecksing



    Drugs & Compounds
    for HLX gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HLX
    Search CenterWatch for drugs/clinical trials and news about HLX 

    Transcripts
    for HLX gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HLX gene: 
    NM_021958.3  

    Unigene Cluster for HLX:

    H2.0-like homeobox
    Hs.74870  [show with all ESTs]
    Unigene Representative Sequence: NM_021958
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366903(uc001hmv.4) ENST00000427693 ENST00000549319

    miRNA
    Products:             		 OriGene 3'-UTR Clone: HLX
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLX
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate HLX (see all 10):
    hsa-miR-30c hsa-miR-520d-5p hsa-miR-128 hsa-miR-3681* hsa-miR-30d hsa-miR-30a hsa-miR-30b hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmid: HLX 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLX (see all 4)
    OriGene shRNA RFP: HLX
    OriGene siRNA: HLX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLX
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLX (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLX
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HLX (NM_021958)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLX 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLX
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HLX
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLX
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLX

    Additional cDNA sequence: 

    AK056326.1 AK127923.1 AK313298.1 BC007294.1 BC033808.1 M60721.1 

    2 DOTS entries:

    DT.410090  DT.95295511 

    24/66 AceView cDNA sequences (see all 66):

    BQ019098 BI909283 NM_021958 BE257965 BC033808 BM972728 BQ020771 AK127923 
    CA436659 BM913402 BQ001899 BU680518 BG390199 BM542542 CR591992 BC007294 
    BG389919 BM550925 BM557295 AK056326 AL555746 AW005147 BM991022 BM557253 

    GeneLoc Exon Structure


    Expression
    for HLX gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HLX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCTGGGTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HLX expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverSinusoidsFetal Hepatic Stellate CellsLiver
    MesodermSeptum TransversumSeptum Transversum Mesenchyme CellsEarly Embryo, Mesoderm
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)

    See HLX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HLX

    SOURCE GeneReport for Unigene cluster: Hs.74870

    UniProtKB/Swiss-Prot: HLX_HUMAN, Q14774
    Tissue specificity: Low level in normal B and T-cells, high level in activated lymphocytes and monocytes. Also found in
    thymus, tonsil, bone marrow, developing vessels, and fetal brain

        SABiosciences Expression via Pathway-Focused PCR Array including HLX: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLX

    Orthologs
    for HLX gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HLX gene from 3/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia HLX6
    		 --
    		 69(a)
    		 1 ↔ 1
    		 1(243672879-243682377)
    zebrafish
    (Danio rerio)    		 Actinopterygii hlx11 H2.0-like homeo box 1 (Drosophila) 63.83(n)
    67.01(a)    		   327096  NM_212701.1  NP_997866.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta H2.06
    		 Homeodomain protein 2.0
    		 19(a)
    		 1 ↔ 1
    		 2L(6013057-6019398)


    ENSEMBL Gene Tree for HLX (if available)
    TreeFam Gene Tree for HLX (if available) 

    Paralogs
    for HLX gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HLX gene
    DBX22  DBX12  HHEX2  
    18/30 SIMAP similar genes for HLX using alignment to 3 protein entries:     HLX_HUMAN (see all proteins) (see all similar genes):
    NKX2-5    EMX1    BARHL2    HOXA3    NKX2-4    BARHL1
    HOXB3    NKX2-6    NKX6-1    DLX1    GBX2    BARX2
    MNX1    NKX2-3    homeobox gene    CDX1    LBX1    BARX1

    HLX for paralogs           About GeneDecksing



    Genomic Variants
    for HLX gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/169 NCBI SNPs in HLX are shown (see all 169)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs674200251,2
    		C,--191727323(+) ATTACT/-TTTCC 1 -- ut511Minor allele frequency- -:0.50CSA 2
    rs1398713581,2
    		C,--221050832(+) TCTTAA/TGAGAG 1 -- us2k10--------
    rs1421347131,2
    		--221050972(+) ACTAGA/GAAGCA 1 -- us2k10--------
    rs797458381,2
    		--221051052(+) TTGCCC/TATGTT 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs1511682171,2
    		--221051076(+) CTTTGC/TCTTCA 1 -- us2k10--------
    rs38404401,2
    		C,--221051334(-) GACTT-/TCTCCT 1 -- us2k10--------
    rs763137791,2
    		--221051455(+) TTCTGG/CGTTTA 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs764250631,2
    		F,--221051497(+) TAAAAA/CTGTCA 1 -- us2k11Minor allele frequency- C:0.12WA 118
    rs1817164961,2
    		--221051532(+) ATTAGG/TGCAAT 1 -- us2k10--------
    rs413690481,2
    		C,F,--221051566(+) TCATTA/GTTCGT 1 -- us2k13Minor allele frequency- G:0.13NA CSA 124

    HapMap Linkage Disequilibrium report for HLX (221051699 - 221059124 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HLX
         1 CNV: 58363
    Human Gene Mutation Database (HGMD): HLX

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLX
    DNA2.0 Custom Variant and Variant Library Synthesis for HLX

    Disorders / Diseases
    for HLX gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HLX for disorders           About GeneDecksing

    OMIM gene information: 142995    OMIM disorders: --

    10 diseases for HLX:    About MalaCards
    congenital diaphragmatic hernia    fryns syndrome    hernia    acute myeloid leukemia
    myeloid leukemia    tonsillitis    acute leukemia    hematopoiesis
    leukemia    asthma

    1 disease from the University of Copenhagen DISEASES database for HLX:
    Congenital diaphragmatic hernia
    Human Genome Epidemiology (HuGE) Navigator: HLX (3 documents)

    Export disorders for HLX gene to outside databases

    Publications
    for HLX gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HLX gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with HLX)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a human homeobox gene that resembles a diverged Drosophila homeobox gene and is expressed in activated lymphocytes. (PubMed id 1676597)1, 2, 3, 9 Deguchi Y....Kehrl J.H. (1991)
    2. Genomic structure, promoter sequence, and revised translation of human homeobox gene HLX1. (PubMed id 7806220)1, 2, 3 Kennedy M.A.... Morris C.M. (1994)
    3. Linkage localization of TGFB2 and the human homeobox gene HLX1 to chromosome 1q. (PubMed id 8095486)1, 2, 9 Nishimura D.Y.... Murray J.C. (1993)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. H2.0-like homeobox regulates early hematopoiesis and p romotes acute myeloid leukemia. (PubMed id 22897850)1 Kawahara M....Steidl U. (2012)
    6. TBX21 and HLX1 polymorphisms influence cytokine secret ion at birth. (PubMed id 22303482)1 Casaca V.I....Schaub B. (2012)
    7. Functional polymorphisms in TBX21 and HLX are associat ed with development and prognosis of Graves' disease. (PubMed id 22014209)1 Morita M....Iwatani Y. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endotheli al cells. (PubMed id 21224470)1 Testori J....Hofer E. (2011)
    10. Homeobox gene HLX is a regulator of HGF/c-met-mediate d migration of human trophoblast-derived cell lines. (PubMed id 20554918)1 Rajaraman G....Kalionis B. (2010)

    External Searches for HLX gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing HLX gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3142 HGNC: 4978 AceView: HLX1 Ensembl:ENSG00000136630 euGenes: HUgn3142
    ECgene: HLX H-InvDB: HLX

    Other Databases showing HLX gene

    (According to HUGE)
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    Specialized Databases showing HLX gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for HLX Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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