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Aliases for HLTF Gene

Aliases for HLTF Gene

  • Helicase-Like Transcription Factor 2 3
  • SMARCA3 3 4 6
  • SNF2L3 3 4 6
  • HIP116 3 4 6
  • SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 3 2 3
  • SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 3 3 4
  • DNA-Binding Protein/Plasminogen Activator Inhibitor 1 Regulator 3 4
  • Sucrose Nonfermenting Protein 2-Like 3 3 4
  • RING Finger Protein 80 3 4
  • HIP116A 3 4
  • RNF80 3 4
  • ZBU1 3 4
  • DNA-Binding Protein/Plasminogen Activator Inhibitor-1 Regulator 3
  • Sucrose Nonfermenting-Like 3 3
  • SNF2-Like 3 3
  • EC 3.6.4.- 4
  • EC 6.3.2.- 4
  • EC 3.6.1 63
  • HLTF1 3

External Ids for HLTF Gene

Previous HGNC Symbols for HLTF Gene

  • SNF2L3
  • SMARCA3

Previous GeneCards Identifiers for HLTF Gene

  • GC03M150231
  • GC03M148747
  • GC03M146119

Summaries for HLTF Gene

Entrez Gene Summary for HLTF Gene

  • This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLTF Gene

HLTF (Helicase-Like Transcription Factor) is a Protein Coding gene. Among its related pathways are RB in Cancer and PEDF Induced Signaling. GO annotations related to this gene include ATPase activity and helicase activity.

UniProtKB/Swiss-Prot for HLTF Gene

  • Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for Lys-63-linked polyubiquitination of chromatin-bound PCNA.

Gene Wiki entry for HLTF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLTF Gene

Genomics for HLTF Gene

Genomic Location for HLTF Gene

Start:
149,030,117 bp from pter
End:
149,086,554 bp from pter
Size:
56,438 bases
Orientation:
Minus strand

Genomic View for HLTF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HLTF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HLTF Gene

Proteins for HLTF Gene

  • Protein details for HLTF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14527-HLTF_HUMAN
    Recommended name:
    Helicase-like transcription factor
    Protein Accession:
    Q14527
    Secondary Accessions:
    • D3DNH3
    • Q14536
    • Q16051
    • Q7KYJ6
    • Q86YA5
    • Q92652
    • Q96KM9

    Protein attributes for HLTF Gene

    Size:
    1009 amino acids
    Molecular mass:
    113929 Da
    Quaternary structure:
    • Interacts with SP1 and SP3 independently of DNA; the interaction with these transcriptional factors may be required for basal transcription of target genes. Interacts with EGR1; the interaction requires prior binding to DNA and represses c-Rel via a DNA looping mechanism (By similarity). Interacts with GATA4 (By similarity). Interacts with PCNA; the interaction promotes polyubiquitination of PCNA through association with the UBE2B-RAD18 and UBE2V2-UBE2N ubiquitin ligase complexes. Interacts with RAD18, SHPRH, UBE2V2 and UBE2N.
    Miscellaneous:
    • Subject to frequent epigenetic inactivation by promoter methylation in colon cancer

    Three dimensional structures from OCA and Proteopedia for HLTF Gene

    Alternative splice isoforms for HLTF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HLTF Gene

Proteomics data for HLTF Gene at MOPED

Selected DME Specific Peptides for HLTF Gene

Post-translational modifications for HLTF Gene

  • Ubiquitination at Lys12, Lys95, Lys158, Lys176, Lys216, Lys258, Lys340, Lys349, Lys355, Lys433, Lys523, Lys571, Lys638, Lys662, Lys682, Lys952, and Lys959
  • Modification sites at PhosphoSitePlus

Other Protein References for HLTF Gene

Domains for HLTF Gene

Gene Families for HLTF Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Suggested Antigen Peptide Sequences for HLTF Gene

Graphical View of Domain Structure for InterPro Entry

Q14527

UniProtKB/Swiss-Prot:

HLTF_HUMAN :
  • Q14527
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with HLTF: view

Function for HLTF Gene

Molecular function for HLTF Gene

UniProtKB/Swiss-Prot Function: Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for Lys-63-linked polyubiquitination of chromatin-bound PCNA.

Enzyme Numbers (IUBMB) for HLTF Gene

Gene Ontology (GO) - Molecular Function for HLTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 10391891
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HLTF: view
genes like me logo Genes that share phenotypes with HLTF: view

Animal Models for HLTF Gene

MGI Knock Outs for HLTF:

miRNA for HLTF Gene

miRTarBase miRNAs that target HLTF

No data available for Transcription Factor Targeting and HOMER Transcription for HLTF Gene

Localization for HLTF Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLTF Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Nuclear localization is stimulated by progesterone. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HLTF Gene COMPARTMENTS Subcellular localization image for HLTF gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HLTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with HLTF: view

Pathways for HLTF Gene

genes like me logo Genes that share pathways with HLTF: view

Pathways by source for HLTF Gene

1 BioSystems pathway for HLTF Gene

UniProtKB/Swiss-Prot Q14527-HLTF_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for HLTF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IEA --
GO:0006200 obsolete ATP catabolic process --
GO:0006301 postreplication repair IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS 7876228
genes like me logo Genes that share ontologies with HLTF: view

Compounds for HLTF Gene

(1) Novoseek inferred chemical compound relationships for HLTF Gene

Compound -log(P) Hits PubMed IDs
azathioprine 27.2 2
genes like me logo Genes that share compounds with HLTF: view

Transcripts for HLTF Gene

Unigene Clusters for HLTF Gene

Helicase-like transcription factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HLTF Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a ·
SP1: - -
SP2: - -
SP3: - -
SP4: -
SP5: -
SP6:

ExUns: 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for HLTF Gene

GeneLoc Exon Structure for
HLTF
ECgene alternative splicing isoforms for
HLTF

Expression for HLTF Gene

mRNA expression in normal human tissues for HLTF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HLTF Gene

SOURCE GeneReport for Unigene cluster for HLTF Gene Hs.3068

mRNA Expression by UniProt/SwissProt for HLTF Gene

Q14527-HLTF_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle.
genes like me logo Genes that share expressions with HLTF: view

No data available for mRNA differential expression in normal tissues for HLTF Gene

Orthologs for HLTF Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HLTF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HLTF 35
  • 99.74 (n)
  • 99.6 (a)
HLTF 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HLTF 35
  • 92.04 (n)
  • 91.38 (a)
HLTF 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HLTF 35
  • 93.68 (n)
  • 93.94 (a)
HLTF 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hltf 35
  • 85.71 (n)
  • 84.15 (a)
Hltf 16
Hltf 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HLTF 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HLTF 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hltf 35
  • 86.62 (n)
  • 83.98 (a)
lizard
(Anolis carolinensis)
Reptilia HLTF 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12354 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hltf 35
  • 66.56 (n)
  • 65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10762 35
zebrafish
(Danio rerio)
Actinopterygii hltf 35
  • 60.32 (n)
  • 60.9 (a)
hltf 36
  • 55 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD16 38
RAD5 36
  • 23 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G05130 35
  • 50.21 (n)
  • 41.96 (a)
rice
(Oryza sativa)
Liliopsida Os07g0642400 35
  • 47.52 (n)
  • 40.73 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07975 35
  • 46.65 (n)
  • 39.17 (a)
Species with no ortholog for HLTF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HLTF Gene

ENSEMBL:
Gene Tree for HLTF (if available)
TreeFam:
Gene Tree for HLTF (if available)

Paralogs for HLTF Gene

Selected SIMAP similar genes for HLTF Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HLTF: view

No data available for Paralogs for HLTF Gene

Variants for HLTF Gene

Sequence variations from dbSNP and Humsavar for HLTF Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2806 -- 149,031,252(-) TGTTA(A/T)GTGTT utr-variant-3-prime
rs746671 -- 149,071,106(-) TTCCT(A/G)TAGTT intron-variant
rs772813 -- 149,077,204(-) ggggc(A/G)ctatc intron-variant
rs772814 -- 149,072,136(-) GTAAT(C/T)CTAGA intron-variant
rs772815 -- 149,068,981(-) gactt(C/T)gcatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HLTF Gene

Variant ID Type Subtype PubMed ID
nsv829752 CNV Loss 17160897
nsv829753 CNV Gain 17160897
nsv528849 CNV Gain 19592680
esv2726035 CNV Deletion 23290073
esv1349617 CNV Deletion 17803354

Relevant External Links for HLTF Gene

HapMap Linkage Disequilibrium report
HLTF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HLTF Gene

Disorders for HLTF Gene

(8) Novoseek inferred disease relationships for HLTF Gene

Disease -log(P) Hits PubMed IDs
colorectal cancer 57.3 14
colon cancer 43 9
gastric cancer 36.7 11
adenoma 31.7 1
tumors 26.8 8
genes like me logo Genes that share disorders with HLTF: view

No data available for UniProtKB/Swiss-Prot for HLTF Gene

Publications for HLTF Gene

  1. The HIP116 SNF2/SW12-related transcription factor gene (SNF2L3) is located on human chromosome 3q25.1-q26.1. (PMID: 7558014) Lin Y. … Evans G.A. (Genomics 1995) 2 3 23
  2. Cloning of an SNF2/SWI2-related protein that binds specifically to the SPH motifs of the SV40 enhancer and to the HIV-1 promoter. (PMID: 7876228) Sheridan P.L. … Jones K.A. (J. Biol. Chem. 1995) 3 4 23
  3. Characterization of a helicase-like transcription factor involved in the expression of the human plasminogen activator inhibitor-1 gene. (PMID: 8672239) Ding H. … Belayew A. (DNA Cell Biol. 1996) 3 4 23
  4. Developmental regulation of Zbu1, a DNA-binding member of the SWI2/SNF2 family. (PMID: 9126292) Gong X. … Rosenthal N. (Dev. Biol. 1997) 3 4 23
  5. Functional interactions between Sp1 or Sp3 and the helicase-like transcription factor mediate basal expression from the human plasminogen activator inhibitor-1 gene. (PMID: 10391891) Ding H. … Belayew A. (J. Biol. Chem. 1999) 3 4 23

Products for HLTF Gene

  • Addgene plasmids for HLTF

Sources for HLTF Gene

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