External Ids for HLF Gene
Previous GeneCards Identifiers for HLF Gene
This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for HLF Gene
HLF (Hepatic Leukemia Factor) is a Protein Coding gene. Diseases associated with HLF include precursor b-cell acute lymphoblastic leukemia and leukemia. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and double-stranded DNA binding. An important paralog of this gene is DBP.