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HLF Gene

protein-coding   GIFtS: 54
GCID: GC17P053342

Hepatic Leukemia Factor

  See HLF-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hepatic Leukemia Factor1 2

External Ids:    HGNC: 49771   Entrez Gene: 31312   Ensembl: ENSG000001089247   OMIM: 1423855   UniProtKB: Q165343   

Export aliases for HLF gene to outside databases

Previous GC identifers: GC17P053073 GC17P055823 GC17P053684 GC17P053817 GC17P050697 GC17P048701


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HLF Gene:
This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription
factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds
sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this
gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced
transcript variants have been described, but their biological validity has not been determined. (provided by
RefSeq, Jul 2008)

GeneCards Summary for HLF Gene:
HLF (hepatic leukemia factor) is a protein-coding gene. Diseases associated with HLF include leukemia, acute lymphoblastic 3. GO annotations related to this gene include double-stranded DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DBP.

Gene Wiki entry for HLF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HLF gene promoter:
         PPAR-gamma1   HSF1short   STAT3   PPAR-gamma2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLF promoter sequence
   Search Chromatin IP Primers for HLF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q22

HLF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLF gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P053342:  view genomic region     (about GC identifiers)

Start:
53,342,321 bp from pter      End:
53,402,426 bp from pter
Size:
60,106 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HLF_HUMAN, Q16534 (See protein sequence)
Recommended Name: Hepatic leukemia factor  
Size: 295 amino acids; 33199 Da
Subunit: Binds DNA specifically as homodimer or heterodimer with other PAR factors
Sequence caution: Sequence=AAA58445.1; Type=Erroneous initiation;
Secondary accessions: A8K1X8 Q6FHS9
Alternative splicing: 2 isoforms:  Q16534-1   Q16534-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HLF: NX_Q16534

Explore proteomics data for HLF at MOPED


See HLF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002117.1  
ENSEMBL proteins: 
 ENSP00000226067   ENSP00000402496   ENSP00000460296   ENSP00000460572   ENSP00000460265  
 ENSP00000461455  

HLF Human Recombinant Protein Products:

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OriGene Protein Over-expression Lysate for HLF
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Novus Biologicals HLF Proteins
Novus Biologicals HLF Lysate
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Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for HLF
Cloud-Clone Corp. Proteins for HLF

 
Search eBioscience for Proteins for HLF 

HLF Antibody Products:

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Abcam antibodies for HLF
Cloud-Clone Corp. Antibodies for HLF
Search ThermoFisher Antibodies for HLF
LSBio Antibodies in human, mouse, rat for HLF

HLF Assay Products:

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Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for HLF
Cloud-Clone Corp. CLIAs for HLF
Search eBioscience for ELISAs for HLF 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR004827 bZIP

Graphical View of Domain Structure for InterPro Entry Q16534

ProtoNet protein and cluster: Q16534

UniProtKB/Swiss-Prot: HLF_HUMAN, Q16534
Similarity: Belongs to the bZIP family. PAR subfamily
Similarity: Contains 1 bZIP (basic-leucine zipper) domain


Find genes that share domains with HLF           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: HLF_HUMAN, Q16534
Induction: Accumulates according to a robust circadian rhythm (By similarity)

     Genatlas biochemistry entry for HLF:
hepatic leukemia factor,rearranged in acute B-cell leukemia,with translocation t(17;19)

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding TAS8639829
GO:0003690double-stranded DNA binding TAS1386162
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IEA--
     
Find genes that share ontologies with HLF           About GenesLikeMe


Phenotypes:
     4 GenomeRNAi human phenotypes for HLF:
 Decreased TP53 protein express  Decreased homologous recombina  G0/1 arrest  Increased G1 DNA content 

     4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hlf):
 behavior/neurological  homeostasis/metabolism  mortality/aging  nervous system 

Find genes that share phenotypes with HLF           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HLF
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HLF

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HLF
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HLF

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat HLF using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate HLF (see all 148):
hsa-miR-579 hsa-miR-361-5p hsa-miR-106a hsa-miR-200b hsa-miR-510 hsa-miR-130b hsa-miR-520b hsa-miR-3918
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for HLF
Predesigned siRNA for gene silencing in human, mouse, rat HLF

Gene Editing
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DNA2.0 Custom Protein Engineering Service for HLF

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OriGene clones in human, mouse for HLF (see all 7)
OriGene ORF clones in mouse, rat for HLF
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HLF (NM_002126)
Sino Biological Human cDNA Clone for HLF
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLF
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLF

Cell Line
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GenScript Custom overexpressing Cell Line Services for HLF
Browse ESI BIO Cell Lines and PureStem Progenitors for HLF 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLF


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
HLF_HUMAN, Q16534: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with HLF           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Array including HLF: 
          Circadian Rhythms in human mouse rat

Interactions:

    GeneGlobe Interaction Network for HLF

STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

Selected Interacting proteins for HLF (Q165343 ENSP000002260674) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
InteractantInteraction Details
GeneCardExternal ID(s)
DBPQ105863, ENSP000002221224I2D: score=3 STRING: ENSP00000222122
CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
HNF4GQ145413, ENSP000003797014I2D: score=1 STRING: ENSP00000379701
MYBP102423, ENSP000003399924I2D: score=1 STRING: ENSP00000339992
RORBQ927533, ENSP000003660934I2D: score=1 STRING: ENSP00000366093
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Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006355regulation of transcription, DNA-templated ----
GO:0006366transcription from RNA polymerase II promoter TAS8639829
GO:0007275multicellular organismal development TAS1386162
GO:0035914skeletal muscle cell differentiation IEA--
GO:0048511rhythmic process IEA--

Find genes that share ontologies with HLF           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HLF

1 Novoseek inferred chemical compound relationship for HLF gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
leucine 35.2 3 1386162 (1), 8639829 (1)



Find genes that share compounds with HLF           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for HLF gene: 
NM_002126.4  

Unigene Cluster for HLF:

Hepatic leukemia factor
Hs.196952  [show with all ESTs]
Unigene Representative Sequence: NM_002126
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000226067(uc002iug.1 uc010dce.1 uc002iuh.2 uc010wni.1)
ENST00000430986 ENST00000573945 ENST00000575345 ENST00000570962 ENST00000572002
ENST00000573020 ENST00000572234 ENST00000573422 ENST00000575868 ENST00000575307

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat HLF using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate HLF (see all 148):
hsa-miR-579 hsa-miR-361-5p hsa-miR-106a hsa-miR-200b hsa-miR-510 hsa-miR-130b hsa-miR-520b hsa-miR-3918
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for HLF
Predesigned siRNA for gene silencing in human, mouse, rat HLF
Clone
Products:
     
OriGene clones in human, mouse for HLF (see all 7)
OriGene ORF clones in mouse, rat for HLF
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HLF (NM_002126)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLF
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLF
Primer
Products:
    
OriGene qPCR primer pairs and template standards for HLF
OriGene qSTAR qPCR primer pairs in human, mouse for HLF
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HLF
  QuantiTect SYBR Green Assays in human, mouse, rat HLF
  QuantiFast Probe-based Assays in human, mouse, rat HLF

Additional mRNA sequence: 

AF035305.1 AK074289.1 AK290043.1 AK295726.1 AK315079.1 BC036093.1 CR541672.1 M95585.1 
X68985.1 

7 DOTS entries:

DT.91770887  DT.95366496  DT.91770884  DT.120964205  DT.120964197  DT.120964186  DT.120964211 

Selected AceView cDNA sequences (see all 126):

F13270 N51143 AI620798 BM724032 F06364 T40949 BF589511 BQ646697 
BQ184685 BF222246 BQ654102 BP383370 AW015274 CA393135 AI288031 BF222577 
BI753190 BU742071 CR541672 X68985 W00959 BP376545 AI418092 CB177316 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for HLF (see all 11)    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11a · 11b · 11c
SP1:        -     -     -                 -     -     -     -     -     -     -     -                                   -                     
SP2:                                                  -     -     -                                                                           
SP3:                                                              -     -     -     -                                   -                     
SP4:                                                                    -                                                                     
SP5:              -     -                 -     -     -     -     -     -     -     -                                                         


ECgene alternative splicing isoforms for HLF

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HLF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATATTGGTGG
HLF Expression
About this image


HLF expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 6) fully expand
 
 Blood (Cardiovascular System)    fully expand to see all 3 entries
         Hematopoietic Stem Cells Hematopoietic Bone Marrow
 
 Brain (Nervous System)    fully expand to see all 2 entries
         Cerebral Cortex
 
 Lung (Respiratory System)
         Basal Cells Trachea
 
 Liver (Hepatobiliary System)
         Hematopoietic Stem Cells Liver Bud
 
 Neural Tube (Nervous System)
         Telencephalon
HLF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HLF Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.196952

UniProtKB/Swiss-Prot: HLF_HUMAN, Q16534
Tissue specificity: Highly expressed in liver; lower levels in lung and kidney

    Pathway & Disease-focused RT2 Profiler PCR Array including HLF: 
          Circadian Rhythms in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for HLF
OriGene qSTAR qPCR primer pairs in human, mouse for HLF
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HLF
QuantiTect SYBR Green Assays in human, mouse, rat HLF
QuantiFast Probe-based Assays in human, mouse, rat HLF
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLF

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for HLF gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hlf1 , 5 hepatic leukemia factor1, 5 91.64(n)1
97.63(a)1
  11 (55.03 cM)5
2170821  NM_172563.31  NP_766151.11 
 903365365 
chicken
(Gallus gallus)
Aves HLF1 hepatic leukemia factor 83.33(n)
90.41(a)
  417395  XM_415649.4  XP_415649.3 
lizard
(Anolis carolinensis)
Reptilia HLF6
hepatic leukemia factor
88(a)
1 ↔ 1
GL343242.1(2142697-2199664)
tropical clawed frog
(Xenopus tropicalis)
Amphibia hlf1 hepatic leukemia factor 77.18(n)
84.41(a)
  100489797  XM_004918559.1  XP_004918616.1 
zebrafish
(Danio rerio)
Actinopterygii hlfa1 hepatic leukemia factor a 73.15(n)
75.09(a)
  768192  NM_001077334.2  NP_001070802.1 
fruit fly
(Drosophila melanogaster)
Insecta Pdp11 PAR-domain protein 1 54.43(n)
55.56(a)
  45588  NM_001274616.1  NP_001261545.1 


ENSEMBL Gene Tree for HLF (if available)
TreeFam Gene Tree for HLF (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HLF gene
DBP2  TEF2  
2 SIMAP similar genes for HLF using alignment to 3 protein entries:     HLF_HUMAN (see all proteins):
TEF    DBP

Find genes that share paralogs with HLF           About GenesLikeMe


1 Pseudogenes.org Pseudogene for HLF
PGOHUM00000260188


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HLF (see all 1192)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs113832351,2
C--48744569(+) ATTGT-/AAAAAA 1 -- int1 trp30--------
rs1443441301,2
--53340381(+) TGGGCA/GTGCTG 1 -- us2k10--------
rs45505111,2
C,F,H--53340408(+) TGTTAC/AACAAA 1 -- us2k122Minor allele frequency- A:0.04NS EA NA WA 2668
rs1145910481,2
F--53340594(+) TTTTTT/AAAAAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs743592011,2
F--53340595(+) TTTTTA/TAAAAA 1 -- us2k11Minor allele frequency- T:0.05WA 118
rs1477925471,2
--53340629(+) TCAGAC/TCGTTC 1 -- us2k10--------
rs792043361,2
C--53340859(+) ACATAA/CCGTGG 1 -- us2k10--------
rs1921668751,2
--53341183(+) ACCACA/CACATC 1 -- us2k10--------
rs1823049231,2
--53341368(+) CTGCAA/GGGGGC 1 -- us2k10--------
rs1866310431,2
--53341372(+) AGGGGA/GCGTCG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for HLF (53342321 - 53402426 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for HLF:    About this table    
Variant IDTypeSubtypePubMed ID
nsv908620CNV Loss21882294
nsv908628CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HLF
DNA2.0 Custom Variant and Variant Library Synthesis for HLF

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 142385    OMIM disorders: --

UniProtKB/Swiss-Prot: HLF_HUMAN, Q16534
  • Note=A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia
    (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3

  • 1 disease for HLF:    
    About MalaCards
    leukemia, acute lymphoblastic 3


    Find genes that share disorders with HLF           About GenesLikeMe

    4 Novoseek inferred disease relationships for HLF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemogenesis 71.1 7 17379095 (2), 7585875 (1), 12700034 (1)
    leukemia 60.2 31 8639829 (3), 17712416 (2), 7556072 (2), 18239067 (2) (see all 14)
    lymphoblastic leukemia acute 48.3 4 20062079 (1), 10023025 (1), 8164688 (1)
    hepatocellular carcinoma 11.3 1 8164688 (1)

    Genatlas disease: HLF
    acute lymphoblastic leukemia,preB-cell,with t(17;19)(q22;p13) translocation (see TCF3),associated with CDNK2A
    and/or CDKN2B deletion

    Genetic Association Database (GAD): HLF
    Human Genome Epidemiology (HuGE) Navigator: HLF (16 documents)

    Export disorders for HLF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HLF gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with HLF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. (PubMed id 1386162)1, 2, 3, 9 Inaba T.... Look A.T. (Science 1992)
    2. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (Alcohol. Clin. Exp. Res. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia. (PubMed id 1516826)1, 2 Hunger S.P.... Cleary M.L. (Genes Dev. 1992)
    5. The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences. (PubMed id 7556072)1, 9 Falvey E....Schibler U. (EMBO J. 1995)
    6. The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. (PubMed id 8639829)1, 9 Hunger S.P.... Cleary M.L. (Blood 1996)
    7. DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein. (PubMed id 8164688)1, 9 Inaba T....Look A.T. (Mol. Cell. Biol. 1994)
    8. Thyroid hormone induces hypoxia-inducible factor 1alpha gene expression through thyroid hormone receptor beta/retinoid x receptor alpha-dependent activation of hepatic leukemia factor. (PubMed id 18239067)1, 9 Otto T. and Fandrey J. (Endocrinology 2008)
    9. E2A basic helix-loop-helix transcription factors in human leukemia. (PubMed id 12700034)1, 9 LeBrun D.P. (Front. Biosci. 2003)
    10. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PubMed id 23263486)1 KAPttgen A....Gieger C. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3131 HGNC: 4977 AceView: HLF Ensembl:ENSG00000108924 euGenes: HUgn3131
    ECgene: HLF H-InvDB: HLF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HLF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HLF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HLF gene:
    Search GeneIP for patents involving HLF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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