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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLF Gene

protein-coding   GIFtS: 54
GCID: GC17P053342

hepatic leukemia factor
 Explore 14 diseases affiliated with
HLF via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HLF    

Aliases
for HLF gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Hepatic Leukemia Factor1 2
MGC338221

External Ids:    HGNC: 49771   Entrez Gene: 31312   Ensembl: ENSG000001089247   OMIM: 1423855   UniProtKB: Q165343   

Export aliases for HLF gene to outside databases

Previous GC identifers: GC17P053073 GC17P055823 GC17P053684 GC17P053817 GC17P050697 GC17P048701


Summaries
for HLF gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HLF:
This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription
factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds
sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene
with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript
variants have been described, but their biological validity has not been determined. (provided by RefSeq, Jul 2008)

Gene Wiki entry for HLF


Genomic Views
for HLF gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLF gene promoter:
         PPAR-gamma1   HSF1short   STAT3   PPAR-gamma2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HLF promoter sequence
   Search SABiosciences Chromatin IP Primers for HLF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q22

HLF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLF gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P053342:  view genomic region     (about GC identifiers)

Start:
 53,342,321 bp from pter      End:
 53,402,426 bp from pter
Size:
 60,106 bases      Orientation:
 plus strand

Proteins
for HLF gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HLF_HUMAN, Q16534 (See protein sequence)
Recommended Name: Hepatic leukemia factor  
Size: 295 amino acids; 33199 Da
Subunit: Binds DNA specifically as homodimer or heterodimer with other PAR factors
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAA58445.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for HLF: NX_Q16534

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16534

    • HLF Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002117.1  
    ENSEMBL proteins: 
     ENSP00000226067   ENSP00000402496   ENSP00000460296   ENSP00000460572   ENSP00000460265  
     ENSP00000461455  

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    Novus Biologicals HLF Proteins
    Novus Biologicals HLF Lysate
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    ProSpec Recombinant Protein for HLF
    Uscn Proteins for HLF

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    HLF for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HLF

    Protein Domains /
    Families
    for HLF gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HLF for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry Q16534

    ProtoNet protein and cluster: Q16534

    UniProtKB/Swiss-Prot: HLF_HUMAN, Q16534
    Similarity: Belongs to the bZIP family. PAR subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Function
    for HLF gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HLF_HUMAN, Q16534
    Induction: Accumulates according to a robust circadian rhythm (By similarity)

         Genatlas biochemistry entry for HLF:
    hepatic leukemia factor,rearranged in acute B-cell leukemia,with translocation t(17;19)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLF
    8/148 QIAGEN miScript miRNA Assays for microRNAs that regulate HLF (see all 148):
    hsa-miR-579 hsa-miR-361-5p hsa-miR-106a hsa-miR-200b hsa-miR-510 hsa-miR-130b hsa-miR-520b hsa-miR-3918
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLF (see all 4)
    OriGene shRNA RFP: HLF
    OriGene siRNA: HLF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLF

    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for HLF

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS8639829
    GO:0003690double-stranded DNA binding TAS1386162
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046983protein dimerization activity ----


    HLF for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for HLF:
     Decreased TP53 protein express  Decreased homologous recombina  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hlf):
     behavior/neurological  homeostasis/metabolism  mortality/aging  nervous system 

    HLF for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HLF gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/21 Interacting proteins for HLF (Q165343 ENSP000002260674) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DBPQ105863, ENSP000002221224I2D: score=3 STRING: ENSP00000222122
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    HNF4GQ145413, ENSP000003797014I2D: score=1 STRING: ENSP00000379701
    MYBP102423, ENSP000003399924I2D: score=1 STRING: ENSP00000339992
    ARNTLO003273, ENSP000003743574I2D: score=2 STRING: ENSP00000374357
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS8639829
    GO:0007275multicellular organismal development TAS1386162
    GO:0048511rhythmic process IEA--


    HLF for ontologies           About GeneDecksing



    Drugs & Compounds
    for HLF gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HLF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HLF
    1 Novoseek chemical compound relationship for HLF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 35.2 3 1386162 (1), 8639829 (1)

    Search CenterWatch for drugs/clinical trials and news about HLF 

    Transcripts
    for HLF gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HLF gene: 
    NM_002126.4  

    Unigene Cluster for HLF:

    Hepatic leukemia factor
    Hs.196952  [show with all ESTs]
    Unigene Representative Sequence: NM_002126
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000226067(uc002iug.1 uc010dce.1 uc002iuh.2 uc010wni.1)
    ENST00000430986 ENST00000573945 ENST00000575345 ENST00000570962 ENST00000572002
    ENST00000573020 ENST00000572234 ENST00000573422 ENST00000575868 ENST00000575307


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLF
    8/148 QIAGEN miScript miRNA Assays for microRNAs that regulate HLF (see all 148):
    hsa-miR-579 hsa-miR-361-5p hsa-miR-106a hsa-miR-200b hsa-miR-510 hsa-miR-130b hsa-miR-520b hsa-miR-3918
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLF (see all 4)
    OriGene shRNA RFP: HLF
    OriGene siRNA: HLF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLF
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLF

    Additional cDNA sequence: 

    AF035305.1 AK074289.1 AK290043.1 AK295726.1 AK315079.1 BC036093.1 CR541672.1 M95585.1 
    X68985.1 

    7 DOTS entries:

    DT.91770887  DT.95366496  DT.91770884  DT.120964205  DT.120964197  DT.120964186  DT.120964211 

    24/126 AceView cDNA sequences (see all 126):

    BI753190 CR541672 T40949 BP383370 CA393135 BF589511 AI620798 AW015274 
    F13270 N51143 AI288031 BF222246 F06364 BQ646697 BF222577 BQ184685 
    BQ654102 BU742071 BM724032 AA777562 CB177316 BC036093 AW237775 BP366775 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for HLF (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11a · 11b · 11c
    SP1:        -     -     -                 -     -     -     -     -     -     -     -                                   -                     
    SP2:                                                  -     -     -                                                                           
    SP3:                                                              -     -     -     -                                   -                     
    SP4:                                                                    -                                                                     
    SP5:              -     -                 -     -     -     -     -     -     -     -                                                         


    ECgene alternative splicing isoforms for HLF

    Expression
    for HLF gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HLF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATATTGGTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HLF expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Skeletal MuscleHyoid Arch MusclesMyoblastsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMyoblastsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HLF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HLF

    SOURCE GeneReport for Unigene cluster: Hs.196952

    UniProtKB/Swiss-Prot: HLF_HUMAN, Q16534
    Tissue specificity: Highly expressed in liver; lower levels in lung and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including HLF: 
              Circadian Rhythms in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for HLF gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HLF gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HLF1 hepatic leukemia factor 83.33(n)
    90.41(a)    		   417395  XM_415649.3  XP_415649.3 
    lizard
    (Anolis carolinensis)    		 Reptilia HLF6
    		 --
    		 88(a)
    		 1 ↔ 1
    		 GL343242.1(2142697-2199664)
    zebrafish
    (Danio rerio)    		 Actinopterygii hlfa1 hepatic leukemia factor a 73.15(n)
    75.09(a)    		   768192  NM_001077334.1  NP_001070802.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Pdp11 PAR-domain protein 1 54.07(n)
    54.84(a)    		   45588  NM_168238.2  NP_729302.2 


    ENSEMBL Gene Tree for HLF (if available)
    TreeFam Gene Tree for HLF (if available) 

    Paralogs
    for HLF gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HLF gene
    DBP2  TEF2  
    2 SIMAP similar genes for HLF using alignment to 5 protein entries:     HLF_HUMAN (see all proteins):
    TEF    DBP

    HLF for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HLF
    PGOHUM00000260188


    Genomic Variants
    for HLF gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/967 NCBI SNPs in HLF are shown (see all 967)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1443441301,2
    		--53340381(+) TGGGCA/GTGCTG 1 -- us2k10--------
    rs45505111,2
    		C,F,H,--53340408(+) TGTTAC/AACAAA 1 -- us2k122Minor allele frequency- A:0.04NS EA NA WA 2668
    rs1145910481,2
    		F,--53340594(+) TTTTTT/AAAAAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs743592011,2
    		F,--53340595(+) TTTTTA/TAAAAA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1477925471,2
    		--53340629(+) TCAGAC/TCGTTC 1 -- us2k10--------
    rs792043361,2
    		C--53340859(+) ACATAA/CCGTGG 1 -- us2k10--------
    rs1921668751,2
    		--53341183(+) ACCACA/CACATC 1 -- us2k10--------
    rs1823049231,2
    		--53341368(+) CTGCAA/GGGGGC 1 -- us2k10--------
    rs1866310431,2
    		--53341372(+) AGGGGA/GCGTCG 1 -- us2k10--------
    rs1397140201,2
    		--53341413(+) GGCGGA/GAAGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HLF (53342321 - 53402426 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HLF: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLF
    DNA2.0 Custom Variant and Variant Library Synthesis for HLF

    Disorders / Diseases
    for HLF gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HLF for disorders           About GeneDecksing

    OMIM gene information: 142385    OMIM disorders: --

    UniProtKB/Swiss-Prot: HLF_HUMAN, Q16534
  • Note=A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL).
    • Translocation t(17;19)(q22;p13.3) with TCF3

    14 diseases for HLF:    About MalaCards
    leukemia    pre-b-cell acute lymphoblastic leukemia    lymphoid leukemia    acute lymphoblastic leukemia
    hepatitis    lymphoblastic leukemia    renal cell carcinoma    hypercalcemia
    hepatocellular carcinoma    t-cell leukemia    carcinoma    fibrosis
    hypoxia    thyroiditis

    4 Novoseek disease relationships for HLF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemogenesis 71.1 7 17379095 (2), 7585875 (1), 12700034 (1)
    leukemia 60.2 31 8639829 (3), 17712416 (2), 7556072 (2), 18239067 (2) (see all 14)
    lymphoblastic leukemia acute 48.3 4 20062079 (1), 10023025 (1), 8164688 (1)
    hepatocellular carcinoma 11.3 1 8164688 (1)

    Genatlas disease: HLF
    acute lymphoblastic leukemia,preB-cell,with t(17;19)(q22;p13) translocation (see TCF3),associated with CDNK2A and/or
    CDKN2B deletion

    Human Genome Epidemiology (HuGE) Navigator: HLF (16 documents)

    Export disorders for HLF gene to outside databases

    Publications
    for HLF gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HLF gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with HLF)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. (PubMed id 1386162)1, 2, 3, 9 Inaba T.... Look A.T. (1992)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia. (PubMed id 1516826)1, 2 Hunger S.P.... Cleary M.L. (1992)
    4. The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences. (PubMed id 7556072)1, 9 Falvey E....Schibler U. (1995)
    5. The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. (PubMed id 8639829)1, 9 Hunger S.P.... Cleary M.L. (1996)
    6. DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein. (PubMed id 8164688)1, 9 Inaba T....Look A.T. (1994)
    7. Thyroid hormone induces hypoxia-inducible factor 1alpha gene expression through thyroid hormone receptor beta/retinoid x receptor alpha-dependent activation of hepatic leukemia factor. (PubMed id 18239067)1, 9 Otto T. and Fandrey J. (2008)
    8. E2A basic helix-loop-helix transcription factors in human leukemia. (PubMed id 12700034)1, 9 LeBrun D.P. (2003)
    9. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    10. The E2A-HLF oncogenic fusion protein acts through Lmo 2 and Bcl-2 to immortalize hematopoietic progenitors. (PubMed id 21072044)1 de Boer J....Brady H.J. (2011)

    External Searches for HLF gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing HLF gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3131 HGNC: 4977 AceView: HLF Ensembl:ENSG00000108924 euGenes: HUgn3131
    ECgene: HLF H-InvDB: HLF

    Other Databases showing HLF gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HLF gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HLF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HLF Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for HLF gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HLF gene:
    Search GeneIP for patents involving HLF

    GeneCards and IP:
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