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Aliases for HLF Gene

Aliases for HLF Gene

  • Hepatic Leukemia Factor 2 3

External Ids for HLF Gene

Previous GeneCards Identifiers for HLF Gene

  • GC17P053073
  • GC17P055823
  • GC17P053684
  • GC17P053817
  • GC17P050697
  • GC17P053342
  • GC17P048701

Summaries for HLF Gene

Entrez Gene Summary for HLF Gene

  • This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLF Gene

HLF (Hepatic Leukemia Factor) is a Protein Coding gene. Diseases associated with HLF include precursor b-cell acute lymphoblastic leukemia. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and double-stranded DNA binding. An important paralog of this gene is DBP.

Gene Wiki entry for HLF Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLF Gene

Genomics for HLF Gene

Regulatory Elements for HLF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HLF Gene

55,264,960 bp from pter
55,325,065 bp from pter
60,106 bases
Plus strand

Genomic View for HLF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HLF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HLF Gene

Proteins for HLF Gene

  • Protein details for HLF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hepatic leukemia factor
    Protein Accession:
    Secondary Accessions:
    • A8K1X8
    • Q6FHS9

    Protein attributes for HLF Gene

    295 amino acids
    Molecular mass:
    33199 Da
    Quaternary structure:
    • Binds DNA specifically as homodimer or heterodimer with other PAR factors
    • Sequence=AAA58445.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HLF Gene


neXtProt entry for HLF Gene

Proteomics data for HLF Gene at MOPED

Post-translational modifications for HLF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HLF Gene

Antibody Products

No data available for DME Specific Peptides for HLF Gene

Domains for HLF Gene

Protein Domains for HLF Gene


Suggested Antigen Peptide Sequences for HLF Gene

Graphical View of Domain Structure for InterPro Entry



  • Q16534
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. PAR subfamily.
genes like me logo Genes that share domains with HLF: view

No data available for Gene Families for HLF Gene

Function for HLF Gene

Molecular function for HLF Gene

GENATLAS Biochemistry:
hepatic leukemia factor,rearranged in acute B-cell leukemia,with translocation t(17;19)
UniProtKB/Swiss-Prot Induction:
Accumulates according to a robust circadian rhythm.

Gene Ontology (GO) - Molecular Function for HLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 8639829
GO:0003690 double-stranded DNA binding TAS 1386162
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HLF: view
genes like me logo Genes that share phenotypes with HLF: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HLF

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HLF Gene

Localization for HLF Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLF Gene


Subcellular locations from

Jensen Localization Image for HLF Gene COMPARTMENTS Subcellular localization image for HLF gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for HLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HLF: view

Pathways for HLF Gene

SuperPathways for HLF Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 8639829
GO:0007275 multicellular organismal development TAS 1386162
GO:0035914 skeletal muscle cell differentiation IEA --
GO:0048511 rhythmic process IEA --
genes like me logo Genes that share ontologies with HLF: view

No data available for Pathways by source for HLF Gene

Compounds for HLF Gene

(1) Novoseek inferred chemical compound relationships for HLF Gene

Compound -log(P) Hits PubMed IDs
leucine 35.2 2
genes like me logo Genes that share compounds with HLF: view

Transcripts for HLF Gene

Unigene Clusters for HLF Gene

Hepatic leukemia factor:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HLF

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HLF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - - - - - - -
SP2: - - -
SP3: - - - - -
SP4: -
SP5: - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - -
SP11: - - - - - - - -

Relevant External Links for HLF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HLF Gene

mRNA expression in normal human tissues for HLF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for HLF Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HLF Gene

SOURCE GeneReport for Unigene cluster for HLF Gene Hs.196952

mRNA Expression by UniProt/SwissProt for HLF Gene

Tissue specificity: Highly expressed in liver; lower levels in lung and kidney
genes like me logo Genes that share expressions with HLF: view

Expression partners for HLF Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HLF Gene

Orthologs for HLF Gene

This gene was present in the common ancestor of animals.

Orthologs for HLF Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HLF 35
  • 89.94 (n)
  • 97.97 (a)
HLF 36
  • 98 (a)
(Canis familiaris)
Mammalia HLF 35
  • 95.25 (n)
  • 99.32 (a)
HLF 36
  • 99 (a)
(Mus musculus)
Mammalia Hlf 35
  • 91.64 (n)
  • 97.63 (a)
Hlf 16
Hlf 36
  • 98 (a)
(Pan troglodytes)
Mammalia HLF 35
  • 99.77 (n)
  • 100 (a)
HLF 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC690286 35
  • 91.75 (n)
  • 97.29 (a)
(Monodelphis domestica)
Mammalia HLF 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia HLF 36
  • 83 (a)
(Gallus gallus)
Aves HLF 35
  • 83.33 (n)
  • 90.41 (a)
HLF 36
  • 90 (a)
(Anolis carolinensis)
Reptilia HLF 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hlf 35
  • 77.18 (n)
  • 84.41 (a)
(Danio rerio)
Actinopterygii hlfa 35
  • 73.15 (n)
  • 75.09 (a)
hlfb 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3939 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006376 35
  • 57.35 (n)
  • 57.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pdp1 35
  • 54.43 (n)
  • 55.56 (a)
Pdp1 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6834 36
  • 13 (a)
Species with no ortholog for HLF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HLF Gene

Gene Tree for HLF (if available)
Gene Tree for HLF (if available)

Paralogs for HLF Gene

Paralogs for HLF Gene

Selected SIMAP similar genes for HLF Gene using alignment to 3 proteins: Pseudogenes for HLF Gene

genes like me logo Genes that share paralogs with HLF: view

Variants for HLF Gene

Sequence variations from dbSNP and Humsavar for HLF Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs13761 -- 55,322,073(+) GTGGT(C/G)TCATT utr-variant-3-prime
rs867956 -- 55,284,599(+) CCTGG(A/G)CACTG intron-variant
rs876719 -- 55,289,205(-) CAAGT(A/C)TGTTT intron-variant
rs876720 -- 55,289,154(-) TTCTG(C/T)AAACC intron-variant
rs884206 -- 55,284,739(+) ACCTG(G/T)GTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HLF Gene

Variant ID Type Subtype PubMed ID
nsv908620 CNV Loss 21882294
nsv908628 CNV Gain 21882294

Relevant External Links for HLF Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HLF Gene

Disorders for HLF Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HLF Gene in MalaCards »

(1) Diseases for HLF Gene including...


  • Note=A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3.

(4) Novoseek inferred disease relationships for HLF Gene

Disease -log(P) Hits PubMed IDs
leukemogenesis 71.1 4
leukemia 60.2 19
lymphoblastic leukemia acute 48.3 3
hepatocellular carcinoma 11.3 1

Genatlas disease for HLF Gene

acute lymphoblastic leukemia,preB-cell,with t(17;19)(q22;p13) translocation (see TCF3),associated with CDNK2A and/or CDKN2B deletion

Relevant External Links for HLF

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HLF: view

No data available for OMIM and University of Copenhagen DISEASES for HLF Gene

Publications for HLF Gene

  1. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. (PMID: 1386162) Inaba T. … Look A.T. (Science 1992) 2 3 4 23
  2. The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences. (PMID: 7556072) Falvey E. … Schibler U. (EMBO J. 1995) 3 23
  3. DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein. (PMID: 8164688) Inaba T. … Look A.T. (Mol. Cell. Biol. 1994) 3 23
  4. The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. (PMID: 8639829) Hunger S.P. … Cleary M.L. (Blood 1996) 3 23
  5. E2A basic helix-loop-helix transcription factors in human leukemia. (PMID: 12700034) LeBrun D.P. (Front. Biosci. 2003) 3 23

Products for HLF Gene

Sources for HLF Gene

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