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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLF Gene

protein-coding   GIFtS: 57
GCID: GC17P053342

Hepatic Leukemia Factor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hepatic Leukemia Factor1 2

External Ids:    HGNC: 49771   Entrez Gene: 31312   Ensembl: ENSG000001089247   OMIM: 1423855   UniProtKB: Q165343   

Export aliases for HLF gene to outside databases

Previous GC identifers: GC17P053073 GC17P055823 GC17P053684 GC17P053817 GC17P050697 GC17P048701


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HLF Gene:
This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription
factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds
sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this
gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced
transcript variants have been described, but their biological validity has not been determined. (provided by
RefSeq, Jul 2008)

GeneCards Summary for HLF Gene: 
HLF (hepatic leukemia factor) is a protein-coding gene. Diseases associated with HLF include familial erythrocytosis 4, and acute lymphoblastic leukemia. GO annotations related to this gene include double-stranded DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is DBP.

Gene Wiki entry for HLF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLF gene promoter:
         PPAR-gamma1   HSF1short   STAT3   PPAR-gamma2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLF promoter sequence
   Search SABiosciences Chromatin IP Primers for HLF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q22

HLF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLF gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P053342:  view genomic region     (about GC identifiers)

Start:
53,342,321 bp from pter      End:
53,402,426 bp from pter
Size:
60,106 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HLF_HUMAN, Q16534 (See protein sequence)
Recommended Name: Hepatic leukemia factor  
Size: 295 amino acids; 33199 Da
Subunit: Binds DNA specifically as homodimer or heterodimer with other PAR factors
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAA58445.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for HLF: NX_Q16534

Explore proteomics data for HLF at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16534

  • HLF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HLF Protein Expression
    REFSEQ proteins: NP_002117.1  
    ENSEMBL proteins: 
     ENSP00000226067   ENSP00000402496   ENSP00000460296   ENSP00000460572   ENSP00000460265  
     ENSP00000461455  

    Human Recombinant Protein Products for HLF: 
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    Novus Biologicals HLF Proteins
    Novus Biologicals HLF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for HLF
    Cloud-Clone Corp. Proteins for HLF 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    HLF for ontologies           About GeneDecksing



    HLF Antibody Products: 
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    Cloud-Clone Corp. CLIAs for HLF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry Q16534

    ProtoNet protein and cluster: Q16534

    UniProtKB/Swiss-Prot: HLF_HUMAN, Q16534
    Similarity: Belongs to the bZIP family. PAR subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    HLF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HLF_HUMAN, Q16534
    Induction: Accumulates according to a robust circadian rhythm (By similarity)

         Genatlas biochemistry entry for HLF:
    hepatic leukemia factor,rearranged in acute B-cell leukemia,with translocation t(17;19)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS8639829
    GO:0003690double-stranded DNA binding TAS1386162
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    HLF for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for HLF:
     Decreased TP53 protein express  Decreased homologous recombina  G0/1 arrest  Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hlf):
     behavior/neurological  homeostasis/metabolism  mortality/aging  nervous system 

    HLF for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HLF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HLF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HLF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HLF 

    miRNA
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    8/148 QIAGEN miScript miRNA Assays for microRNAs that regulate HLF (see all 148):
    hsa-miR-579 hsa-miR-361-5p hsa-miR-106a hsa-miR-200b hsa-miR-510 hsa-miR-130b hsa-miR-520b hsa-miR-3918
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                         Customized lentivirus expression plasmids for stable overexpression of HLF 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/21 Interacting proteins for HLF (Q165343 ENSP000002260674) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DBPQ105863, ENSP000002221224I2D: score=3 STRING: ENSP00000222122
    CREBBPQ927933, ENSP000002623674I2D: score=1 STRING: ENSP00000262367
    HNF4GQ145413, ENSP000003797014I2D: score=1 STRING: ENSP00000379701
    MYBP102423, ENSP000003399924I2D: score=1 STRING: ENSP00000339992
    ARNTLO003273, ENSP000003743574I2D: score=2 STRING: ENSP00000374357
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS8639829
    GO:0007275multicellular organismal development TAS1386162
    GO:0035914skeletal muscle cell differentiation IEA--
    GO:0048511rhythmic process IEA--

    HLF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HLF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HLF

    1 Novoseek inferred chemical compound relationship for HLF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 35.2 3 1386162 (1), 8639829 (1)

    Search CenterWatch for drugs/clinical trials and news about HLF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HLF gene: 
    NM_002126.4  

    Unigene Cluster for HLF:

    Hepatic leukemia factor
    Hs.196952  [show with all ESTs]
    Unigene Representative Sequence: NM_002126
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000226067(uc002iug.1 uc010dce.1 uc002iuh.2 uc010wni.1)
    ENST00000430986 ENST00000573945 ENST00000575345 ENST00000570962 ENST00000572002
    ENST00000573020 ENST00000572234 ENST00000573422 ENST00000575868 ENST00000575307

    miRNA
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    8/148 QIAGEN miScript miRNA Assays for microRNAs that regulate HLF (see all 148):
    hsa-miR-579 hsa-miR-361-5p hsa-miR-106a hsa-miR-200b hsa-miR-510 hsa-miR-130b hsa-miR-520b hsa-miR-3918
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HLF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLF
    Clone
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    OriGene clones in human, mouse for HLF (see all 7)
    OriGene ORF clones in mouse, rat for HLF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLF (NM_002126)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLF
    Sirion Biotech Customized lentivirus for stable overexpression of HLF 
                         Customized lentivirus expression plasmids for stable overexpression of HLF 
    Primer
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    OriGene qPCR primer pairs and template standards for HLF
    OriGene qSTAR qPCR primer pairs in human, mouse for HLF
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLF

    Additional mRNA sequence: 

    AF035305.1 AK074289.1 AK290043.1 AK295726.1 AK315079.1 BC036093.1 CR541672.1 M95585.1 
    X68985.1 

    7 DOTS entries:

    DT.91770887  DT.95366496  DT.91770884  DT.120964205  DT.120964197  DT.120964186  DT.120964211 

    24/126 AceView cDNA sequences (see all 126):

    BU742071 BF222577 AI620798 BQ654102 CA393135 BF222246 CR541672 BQ646697 
    BM724032 BF589511 AW015274 BQ184685 F06364 BI753190 F13270 AI288031 
    T40949 BP383370 N51143 F04390 BX507785 AK074289 BQ709647 AW298316 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for HLF (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11a · 11b · 11c
    SP1:        -     -     -                 -     -     -     -     -     -     -     -                                   -                     
    SP2:                                                  -     -     -                                                                           
    SP3:                                                              -     -     -     -                                   -                     
    SP4:                                                                    -                                                                     
    SP5:              -     -                 -     -     -     -     -     -     -     -                                                         


    ECgene alternative splicing isoforms for HLF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HLF expression in normal human tissues (normalized intensities)      HLF embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATTGGTGG
    HLF Expression
    About this image


    HLF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             brain/forebrain/telencephalon   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Uterus (Reproductive System)
             cervix   
     
     Lower Urinary Tract (Urinary System)
             visceral organ   

    See HLF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HLF

    SOURCE GeneReport for Unigene cluster: Hs.196952

    UniProtKB/Swiss-Prot: HLF_HUMAN, Q16534
    Tissue specificity: Highly expressed in liver; lower levels in lung and kidney

        SABiosciences Expression via Pathway-Focused PCR Array including HLF: 
              Circadian Rhythms in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HLF gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hlf1 , 5 hepatic leukemia factor1, 5 91.64(n)1
    97.63(a)1
      11 (55.03 cM)5
    2170821  NM_172563.31  NP_766151.11 
     903365365 
    chicken
    (Gallus gallus)
    Aves HLF1 hepatic leukemia factor 83.33(n)
    90.41(a)
      417395  XM_415649.3  XP_415649.3 
    lizard
    (Anolis carolinensis)
    Reptilia HLF6
    Uncharacterized protein
    88(a)
    1 ↔ 1
    GL343242.1(2142697-2199664)
    zebrafish
    (Danio rerio)
    Actinopterygii hlfa1 hepatic leukemia factor a 73.15(n)
    75.09(a)
      768192  NM_001077334.1  NP_001070802.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pdp11 PAR-domain protein 1 54.07(n)
    54.84(a)
      45588  NM_168238.2  NP_729302.2 
    worm
    (Caenorhabditis elegans)
    Secernentea zip-76
    Protein ZIP-7
    16(a)
    1 ↔ 1
    IV(16503323-16505682)


    ENSEMBL Gene Tree for HLF (if available)
    TreeFam Gene Tree for HLF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HLF gene
    DBP2  TEF2  
    2 SIMAP similar genes for HLF using alignment to 5 protein entries:     HLF_HUMAN (see all proteins):
    TEF    DBP

    HLF for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HLF
    PGOHUM00000260188


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1192 SNPs in HLF are shown (see all 1192)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0085154
    ----see VAR_0085152 I F mis40--------
    rs113832351,2
    C--48744569(+) ATTGT-/AAAAAA 1 -- int1 trp30--------
    rs1443441301,2
    --53340381(+) TGGGCA/GTGCTG 1 -- us2k10--------
    rs45505111,2
    C,F,H--53340408(+) TGTTAC/AACAAA 1 -- us2k122Minor allele frequency- A:0.04NS EA NA WA 2668
    rs1145910481,2
    F--53340594(+) TTTTTT/AAAAAA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs743592011,2
    F--53340595(+) TTTTTA/TAAAAA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1477925471,2
    --53340629(+) TCAGAC/TCGTTC 1 -- us2k10--------
    rs792043361,2
    C--53340859(+) ACATAA/CCGTGG 1 -- us2k10--------
    rs1921668751,2
    --53341183(+) ACCACA/CACATC 1 -- us2k10--------
    rs1823049231,2
    --53341368(+) CTGCAA/GGGGGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HLF (53342321 - 53402426 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HLF:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv908620CNV Loss21882294
    nsv908628CNV Gain21882294


    Human Gene Mutation Database (HGMD): HLF
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142385    OMIM disorders: --

    UniProtKB/Swiss-Prot: HLF_HUMAN, Q16534
  • Note=A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia
    (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3

  • 11 diseases for HLF:    About MalaCards
    familial erythrocytosis 4    acute lymphoblastic leukemia    lymphoblastic leukemia    leukemia
    hypercalcemia    hepatitis    hepatocellular carcinoma    t-cell leukemia
    renal cell carcinoma    hypoxia    thyroiditis


    HLF for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for HLF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemogenesis 71.1 7 17379095 (2), 7585875 (1), 12700034 (1)
    leukemia 60.2 31 8639829 (3), 17712416 (2), 7556072 (2), 18239067 (2) (see all 14)
    lymphoblastic leukemia acute 48.3 4 20062079 (1), 10023025 (1), 8164688 (1)
    hepatocellular carcinoma 11.3 1 8164688 (1)

    Genatlas disease: HLF
    acute lymphoblastic leukemia,preB-cell,with t(17;19)(q22;p13) translocation (see TCF3),associated with CDNK2A
    and/or CDKN2B deletion

    Genetic Association Database (GAD): HLF
    Human Genome Epidemiology (HuGE) Navigator: HLF (16 documents)

    Export disorders for HLF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HLF gene, integrated from 9 sources (see all 49):
    (articles sorted by number of sources associating them with HLF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. (PubMed id 1386162)1, 2, 3, 9 Inaba T.... Look A.T. (1992)
    2. Human Variation in Alcohol Response Is Influenced by Variation in Neuronal Signaling Genes. (PubMed id 20201926)1, 4 Joslyn G....White R.L. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia. (PubMed id 1516826)1, 2 Hunger S.P.... Cleary M.L. (1992)
    5. The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences. (PubMed id 7556072)1, 9 Falvey E....Schibler U. (1995)
    6. The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. (PubMed id 8639829)1, 9 Hunger S.P.... Cleary M.L. (1996)
    7. DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein. (PubMed id 8164688)1, 9 Inaba T....Look A.T. (1994)
    8. Thyroid hormone induces hypoxia-inducible factor 1alpha gene expression through thyroid hormone receptor beta/retinoid x receptor alpha-dependent activation of hepatic leukemia factor. (PubMed id 18239067)1, 9 Otto T. and Fandrey J. (2008)
    9. E2A basic helix-loop-helix transcription factors in human leukemia. (PubMed id 12700034)1, 9 LeBrun D.P. (2003)
    10. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PubMed id 23263486)1 Kottgen A....Gieger C. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3131 HGNC: 4977 AceView: HLF Ensembl:ENSG00000108924 euGenes: HUgn3131
    ECgene: HLF H-InvDB: HLF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HLF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HLF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HLF gene:
    Search GeneIP for patents involving HLF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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