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Aliases for HLA-L Gene

Aliases for HLA-L Gene

  • Major Histocompatibility Complex, Class I, L (Pseudogene) 2 3 5
  • HLA-92 3
  • HLA92 3
  • HLAL 3

External Ids for HLA-L Gene

Previous HGNC Symbols for HLA-L Gene

  • HLA92
  • HLAL

Previous GeneCards Identifiers for HLA-L Gene

  • GC06U990059
  • GC06P030332
  • GC06P030334
  • GC06P030226
  • GC06P030370
  • GC06P030316
  • GC06P030417
  • GC06P030432
  • GC06P030520
  • GC06P030728

Summaries for HLA-L Gene

GeneCards Summary for HLA-L Gene

HLA-L (Major Histocompatibility Complex, Class I, L (Pseudogene)) is a Pseudogene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-L Gene

Genomics for HLA-L Gene

Regulatory Elements for HLA-L Gene

Enhancers for HLA-L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G030321 1.4 Ensembl ENCODE dbSUPER 21.2 +63.2 63240 2.3 PKNOX1 EGR1 SCRT2 KLF13 ZNF362 CAVIN1 ZBTB2 CEBPB ZNF398 HDAC8 HCG18 HLA-L HLA-U RPL23AP1 IFITM4P HLA-F-AS1 ENSG00000272236 HCG9P5 DHX16 PPP1R11
GH06G030258 1 ENCODE 22.5 +0.1 96 1.7 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZNF143 FOS ZNF263 ZNF202 HLA-U HLA-L HCG18 DHX16 HCG4P7 HLA-H HLA-F-AS1 PAIP1P1 HLA-J MICE
GH06G030777 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +522.8 522804 10.1 CREB3L1 MLX ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF263 SP3 NFYC IER3 PPP1R10 PAIP1P1 VARS2 LY6G5B GTF2H4 DHX16 NFKBIL1 DDR1 ETF1P1
GH06G030787 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +529.1 529090 1.7 ELF3 TBP ARID4B RARA ZNF121 CREM MIXL1 THAP11 SMARCA5 SP5 IER3 VARS2 FLOT1 DDR1-AS1 DDR1 HLA-L GTF2H4 DPCR1 HCG20 HCG21
GH06G030816 2 FANTOM5 Ensembl ENCODE dbSUPER 8.3 +560.4 560359 6.6 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SLC30A9 ZNF143 FOS KLF13 IER3 DDR1 HLA-E PPP1R18 LINC00243 FLOT1 HCG18 VARS2 DDR1-AS1 PRR3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HLA-L on UCSC Golden Path with GeneCards custom track

Promoters for HLA-L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195381 238 1201 ATF1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 ZNF143 FOS ZNF263 ZNF202

Genomic Location for HLA-L Gene

Chromosome:
6
Start:
30,259,562 bp from pter
End:
30,293,014 bp from pter
Size:
33,453 bases
Orientation:
Plus strand

Genomic View for HLA-L Gene

Genes around HLA-L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-L Gene

Post-translational modifications for HLA-L Gene

No Post-translational modifications

No data available for DME Specific Peptides for HLA-L Gene

Domains & Families for HLA-L Gene

Gene Families for HLA-L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HLA-L: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HLA-L Gene

Function for HLA-L Gene

Molecular function for HLA-L Gene

GENATLAS Biochemistry:
HLA class I-like gene L,9.2 Hind III fragment,see MHC1
genes like me logo Genes that share phenotypes with HLA-L: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HLA-L Gene

Localization for HLA-L Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HLA-L Gene

Pathways & Interactions for HLA-L Gene

SuperPathways for HLA-L Gene

No Data Available

Interacting Proteins for HLA-L Gene

Gene Ontology (GO) - Biological Process for HLA-L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HLA-L Gene

Transcripts for HLA-L Gene

mRNA/cDNA for HLA-L Gene

(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-L Gene

No ASD Table

Relevant External Links for HLA-L Gene

GeneLoc Exon Structure for
HLA-L
ECgene alternative splicing isoforms for
HLA-L

Expression for HLA-L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HLA-L Gene

genes like me logo Genes that share expression patterns with HLA-L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-L Gene

Orthologs for HLA-L Gene

Evolution for HLA-L Gene

ENSEMBL:
Gene Tree for HLA-L (if available)
TreeFam:
Gene Tree for HLA-L (if available)

No data available for Orthologs for HLA-L Gene

Paralogs for HLA-L Gene

No data available for Paralogs for HLA-L Gene

Variants for HLA-L Gene

Sequence variations from dbSNP and Humsavar for HLA-L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000406548 -- 30,262,742(+) TCAAG(C/T)TTTTT intron-variant
rs1000638097 -- 30,265,281(+) ATGTT(G/T)CTGTT intron-variant, nc-transcript-variant
rs1000964674 -- 30,258,351(+) CAGGA(-/AGTGAGGGAC)AGTGT intron-variant, upstream-variant-2KB
rs1001146954 -- 30,261,393(+) GGTGG(C/G)TGTAG intron-variant, nc-transcript-variant
rs1001568576 -- 30,262,741(+) TCAAG(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HLA-L Gene

Variant ID Type Subtype PubMed ID
esv2731777 CNV deletion 23290073
esv2731782 CNV deletion 23290073
esv2731783 CNV deletion 23290073
esv2731785 CNV deletion 23290073
esv2731786 CNV deletion 23290073
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv601264 CNV loss 21841781

Relevant External Links for HLA-L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HLA-L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HLA-L Gene

Disorders for HLA-L Gene

Relevant External Links for HLA-L

Genetic Association Database (GAD)
HLA-L
Human Genome Epidemiology (HuGE) Navigator
HLA-L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HLA-L

No disorders were found for HLA-L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HLA-L Gene

Publications for HLA-L Gene

  1. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  2. Examination of four HLA class I pseudogenes. Common events in the evolution of HLA genes and pseudogenes. (PMID: 1517564) Geraghty D.E. … Hansen J.A. (J. Immunol. 1992) 2 3 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64

Products for HLA-L Gene

Sources for HLA-L Gene

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