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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLA-H Gene

pseudogene   GIFtS: 42
GCID: GC06P030063

Major Histocompatibility Complex, Class I, H (Pseudogene)

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Major Histocompatibility Complex, Class I, H (Pseudogene)1 2     MHC Class I Antigen H3
HLAHP2     HFE5
HLA-12.43     HFE15
HLA-AR3     MVCD75
HLAH3     

External Ids:    HGNC: 49651   Entrez Gene: 31362   Ensembl: ENSG000002063417   OMIM: 6136095   UniProtKB: P018933   
ORGUL members:         
NONCODE14:n405299      

Export aliases for HLA-H gene to outside databases

Previous GC identifers: GC06P029926 GC06M029910 GC06P029962 GC06P029963 GC06P029912 GC06Pf29990 GC06P029858 GC06P029655


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HLA-H Gene:
This major histocompatibility complex gene represents a transcribed pseudogene, possibly derived from HLA-A. This
gene displays extensive variation. (provided by RefSeq, May 2010)

GeneCards Summary for HLA-H Gene: 
HLA-H (major histocompatibility complex, class I, H (pseudogene)) is a pseudogene, and is affiliated with the lncRNA class. Diseases associated with HLA-H include microvascular complications of diabetes 7, and hfe-associated hereditary hemochromatosis, and among its related super-pathways are ER-Phagosome pathway. GO annotations related to this gene include MHC class I receptor activity.

UniProtKB/Swiss-Prot: HLAH_HUMAN, P01893
Function: Involved in the presentation of foreign antigens to the immune system




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLA-H gene promoter:
         STAT1   AML1a   Olf-1   MyoD   STAT5A   Nkx2-5   AP-2gamma   Egr-4   En-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLA-H promoter sequence
   Search SABiosciences Chromatin IP Primers for HLA-H

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-H


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.3

HLA-H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-H gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P030063:  view genomic region     (about GC identifiers)

Start:
29,855,350 bp from pter      End:
29,858,856 bp from pter
Size:
3,507 bases      Orientation:
plus strand

6/7 alternative locations (see all 7):
Chr6+,NT_167247 1,150,036-1,153,497      Chr6+,NT_167245 1,150,399-1,153,860      Chr6+,NT_167246 1,149,678-1,153,133     
Chr6+,NT_167249 1,186,740-1,190,195      Chr6+,NT_113891.2 1,369,125-1,372,586      Chr6+,NT_167248 1,150,076-1,153,536     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HLAH_HUMAN, P01893 (See protein sequence)
Recommended Name: Putative HLA class I histocompatibility antigen, alpha chain H precursor  
Size: 362 amino acids; 40892 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin)
Subcellular location: Cell membrane; Single-pass membrane protein (Potential)
Caution: Could be the product of a pseudogene
Sequence caution: Sequence=AAA36218.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Explore the universe of human proteins at neXtProt for HLA-H: NX_P01893

Explore proteomics data for HLA-H at MOPED 

HLA-H Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

HLA-H Protein Expression

Human Recombinant Protein Products for HLA-H: 

Browse Purified and Recombinant Proteins at EMD Millipore
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OriGene Custom MassSpec 
OriGene Custom Protein Services for HLA-H
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Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005887integral to plasma membrane NAS6461010
GO:0042612MHC class I protein complex IEA--

HLA-H for ontologies           About GeneDecksing



HLA-H Antibody Products: 
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Assay Products for HLA-H: 
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Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for HLA-H
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
HLA: Histocompatibility complex

5/8 InterPro protein domains (see all 8):
 IPR011162 MHC_I/II-like_Ag-recog
 IPR013783 Ig-like_fold
 IPR003597 Ig_C1-set
 IPR007110 Ig-like_dom
 IPR003006 Ig/MHC_CS

Graphical View of Domain Structure for InterPro Entry P01893

ProtoNet protein and cluster: P01893

3 Blocks protein domains:
IPB001039 MHC class I signature
IPB003597 Immunoglobulin C-type
IPB010579 MHC_I


UniProtKB/Swiss-Prot: HLAH_HUMAN, P01893
Similarity: Belongs to the MHC class I family
Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


HLA-H for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: HLAH_HUMAN, P01893
Function: Involved in the presentation of foreign antigens to the immune system

     Genatlas biochemistry entry for HLA-H:
HLA class I-like gene H,5.4 Hind III fragment,see HFEC@,MHC1

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0042605peptide antigen binding IEA--
     
HLA-H for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for HLA-H 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HLA-H

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HLA-H 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HLA-H 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-H
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HLA-H
SwitchGear 3'UTR luciferase reporter plasmidHLA-H 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for HLA-H
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-H

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for HLA-H
Sirion Biotech Customized adenovirus for overexpression of HLA-H

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for HLA-H (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for HLA-H
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-H
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HLA-H
Sirion Biotech Customized lentivirus for stable overexpression of HLA-H 
                     Customized lentivirus expression plasmids for stable overexpression of HLA-H 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for HLA-H
Search LifeMap BioReagents cell lines for HLA-H
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-H


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for HLA-H About                                                                                                See pathways by source

SuperPathContained pathways About
1CDK-mediated phosphorylation and removal of Cdc6
Proteasome Degradation0.57


1 BioSystems Pathway for HLA-H
    Proteasome Degradation


Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HLA-H

1 Interacting protein for HLA-H (P018933) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
SQSTM1Q135013I2D: score=1 
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001916positive regulation of T cell mediated cytotoxicity IEA--
GO:0002474antigen processing and presentation of peptide antigen via MHC class I IEA--
GO:0006955immune response NAS6461010

HLA-H for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HLA-H (HLAH)

Search CenterWatch for drugs/clinical trials and news about HLA-H

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for HLA-H:

Major histocompatibility complex, class I, H (pseudogene)
Hs.728808  [show with all ESTs]
Unigene Representative Sequence: AK090500
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000383620(uc021ytv.1 uc021ytw.1 uc021ytx.1) ENST00000383326(uc010jro.3)


miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-H
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HLA-H
SwitchGear 3'UTR luciferase reporter plasmidHLA-H 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for HLA-H
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-H
Clone
Products:
     
OriGene clones in human, mouse for HLA-H (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for HLA-H
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-H
Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HLA-H
Sirion Biotech Customized lentivirus for stable overexpression of HLA-H 
                     Customized lentivirus expression plasmids for stable overexpression of HLA-H 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for HLA-H
OriGene qSTAR qPCR primer pairs in human, mouse for HLA-H
Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat HLA-H
  Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-H
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-H

Additional mRNA sequence: 

AK090500.1 AK293556.1 AK299998.1 AK300878.1 AK308374.1 AK309163.1 AK309480.1 NR_001434.2 

21 DOTS entries:

DT.100058894  DT.91680045  DT.100855576  DT.86995001  DT.95223958  DT.95376774  DT.100044088  DT.100647401 
DT.100733374  DT.100733386  DT.100733433  DT.100849442  DT.121310281  DT.453586  DT.75111233  DT.91783956 
DT.91787286  DT.91911697  DT.95270461  DT.95376642  DT.95378900 

24/1003 AceView cDNA sequences (see all 1003):

AA350145 BQ708753 AI418980 BQ690219 BM552783 CA425346 AI818330 BX439073 
AI284570 CD251222 CB120660 BP333972 CA439575 BQ940569 BQ672728 CD107990 
AY216681 CA435477 AA342673 AW337407 AA554671 BU157626 BM694321 AA085553 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HLA-H expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
HLA-H Expression
About this image


See HLA-H Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.728808
    SABiosciences Custom PCR Arrays for HLA-H
Primer
Products:
OriGene qPCR primer pairs and template standards for HLA-H
OriGene qSTAR qPCR primer pairs in human, mouse for HLA-H
Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat HLA-H
Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-H
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-H
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-H

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for HLA-H (if available)
TreeFam Gene Tree for HLA-H (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for HLA-H gene
18/110 SIMAP similar genes for HLA-H using alignment to 2 protein entries:     HLAH_HUMAN (see all proteins) (see all similar genes):
HLA-A*0201V3    HLA-ABC    HLA-B*27    B-1510    DKFZp686N10220    HLA-A*01
HLA-A24AK    HLA-B41    HLA-Cw3    HLA-B27    HLA-B52    Cw
HLA B    HLA C*    HLA-A*02    HLA-A*0226    HLA-A*2410    HLA-B*07ML

HLA-H for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/447 SNPs in HLA-H are shown (see all 447)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2011355691,2
--29853419(+) AAAAA-/AAAT  
        
AGCCA
1 -- us2k10--------
rs1120088321,2
C--29853421(+) AAAAAT/ATAGCC 1 -- us2k11Minor allele frequency- A:0.50NA 2
rs285331231,2
--29853423(+) AAAATG/AGCCAA 1 -- us2k11Minor allele frequency- A:0.00NA 2
rs16115971,2
C,F,H--29853430(+) CCAAGC/TGTAGT 1 -- us2k13Minor allele frequency- T:0.33NA 6
rs563893011,2
--29853434(+) GCGTAC/GTGGCG 1 -- us2k10--------
rs25238021,2
C,F,A,H--29853438(-) CACCCA/C/GCCACT 1 -- us2k12NA 4
rs1123494291,2
C--29853449(+) CCTGTG/AGTCCC 1 -- us2k11Minor allele frequency- A:0.50WA 2
rs28939921,2
C--29853494(+) GAACCT/CGGGAG 1 -- us2k15Minor allele frequency- C:0.00NA WA CSA 9
rs45246311,2
C--29853514(+) GCAGTG/AAGCCG 1 -- us2k18Minor allele frequency- A:0.32NA WA CSA 249
rs92591721,2
C--29853526(+) GATCCG/CGCCAC 1 -- us2k17Minor allele frequency- C:0.34NA WA CSA 247

HapMap Linkage Disequilibrium report for HLA-H (29855350 - 29858856 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/67 variations for HLA-H (see all 67):    About this table     
Variant IDTypeSubtypePubMed ID
dgv7e195CNV Deletion20811451
esv2670487CNV Deletion23128226
dgv1039e201CNV Deletion23290073
esv2665698CNV Deletion23128226
esv3124CNV Deletion18987735
dgv1087e199CNV Deletion23128226
esv2731772CNV Deletion23290073
esv2422126CNV Deletion20811451
dgv1086e199CNV Deletion23128226
nsv820564CNV Deletion20802225


Locus Specific Mutation Databases (LSDB): HLA-H
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing HLA-H
DNA2.0 Custom Variant and Variant Library Synthesis for HLA-H

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 613609   
OMIM disorders: 235200  612635  176200  176100  104300  190000  
10 diseases for HLA-H:    About MalaCards
microvascular complications of diabetes 7    hfe-associated hereditary hemochromatosis    porphyria cutanea tarda    porphyria
hemochromatosis    alzheimer's disease    crohn's disease    hepatitis b
hepatitis    leukemia


HLA-H for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): HLA-H
Human Genome Epidemiology (HuGE) Navigator: HLA-H (3360 documents)

Export disorders for HLA-H gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for HLA-H gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with HLA-H)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Transcription analysis, physical mapping, and molecular characterization of a nonclassical human leukocyte antigen class I gene. (PubMed id 2294403)1, 3, 9 Chorney M.J....Weissman S.M. (1990)
  2. Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation. (PubMed id 15350465)1, 4 Kotzampasaki E.M....Stavropoulos-Giokas C. (2004)
  3. [Role of polymorphic adhesion molecules in the development of graft-versus-leukemia effect after HLA-matched allogeneic stem cell transplantation] (PubMed id 15359910)1, 4 Shiobara S....Nakao S. (2004)
  4. Examination of four HLA class I pseudogenes. Common events in the evolution of HLA genes and pseudogenes. (PubMed id 1517564)1, 3 Geraghty D.E....Hansen J.A. (1992)
  5. Exon/intron organization and complete nucleotide sequence of an HLA gene. (PubMed id 6461010)1, 2 Malissen M.... Jordan B.R. (1982)
  6. HLA-H: a pseudogene with increased variation due to balancing selection at neighboring loci. (PubMed id 9866194)1, 9 Grimsley C....Ober C. (1998)
  7. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (2012)
  8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
  9. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
  10. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3136 HGNC: 4965 AceView: HLA-EandRANP1andFLJ45422 Ensembl:ENSG00000206341 euGenes: HUgn3136
ECgene: HLA-H H-InvDB: HLA-H

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for HLA-H Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HLA-H gene:
Search GeneIP for patents involving HLA-H

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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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