Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HLA-H Gene

pseudogene   GIFtS: 41
GCID: GC06P030178

Major Histocompatibility Complex, Class I, H (Pseudogene)

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Major Histocompatibility Complex, Class I, H (Pseudogene)1 2     MHC Class I Antigen H3
HLAHP2     HLA-HA15
HLA-12.43     HMHA15
HLA-AR3     KIAA02235
HLAH3     

External Ids:    HGNC: 49651   Entrez Gene: 31362   Ensembl: ENSG000002063417   OMIM: 6011555   UniProtKB: P018933   

Export aliases for HLA-H gene to outside databases

Previous GC identifers: GC06P029926 GC06M029910 GC06P029962 GC06P029963 GC06P029912 GC06Pf29990 GC06P029858 GC06P029655 GC06P030063


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HLA-H Gene:
This major histocompatibility complex gene represents a transcribed pseudogene, possibly derived from HLA-A. This
gene displays extensive variation. (provided by RefSeq, May 2010)

GeneCards Summary for HLA-H Gene:
HLA-H (major histocompatibility complex, class I, H (pseudogene)) is a pseudogene. Diseases associated with HLA-H include microvascular complications of diabetes 7, and hemochromatosis. GO annotations related to this gene include peptide antigen binding.

UniProtKB/Swiss-Prot: HLAH_HUMAN, P01893
Function: Involved in the presentation of foreign antigens to the immune system




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the HLA-H gene promoter:
         STAT1   AML1a   Olf-1   MyoD   STAT5A   Nkx2-5   AP-2gamma   Egr-4   En-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLA-H promoter sequence
   Search Chromatin IP Primers for HLA-H

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-H


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.3

HLA-H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-H gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P030178:  view genomic region     (about GC identifiers)

Start:
29,855,350 bp from pter      End:
29,858,856 bp from pter
Size:
3,507 bases      Orientation:
plus strand

Selected alternative locations (see all 7):
Chr6+,NT_167245 1,150,399-1,153,860      Chr6+,NT_167248 1,150,076-1,153,536      Chr6+,NT_167247 1,150,036-1,153,497     
Chr6+,NT_167249 1,186,740-1,190,195      Chr6+,NT_113891.2 1,369,125-1,372,586      Chr6+,NT_167246 1,149,678-1,153,133     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HLAH_HUMAN, P01893 (See protein sequence)
Recommended Name: Putative HLA class I histocompatibility antigen, alpha chain H precursor  
Size: 362 amino acids; 40892 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin)
Caution: Could be the product of a pseudogene
Sequence caution: Sequence=AAA36218.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Explore the universe of human proteins at neXtProt for HLA-H: NX_P01893

Explore proteomics data for HLA-H at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn110

  • See HLA-H Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


    HLA-H Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HLA-H
    GenScript Custom Purified and Recombinant Proteins Services for HLA-H
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    HLA-H Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HLA-H
    Novus Biologicals HLA-H Antibody
    Abcam antibodies for HLA-H
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for HLA-H
    LSBio Antibodies in human, mouse, rat for HLA-H

    HLA-H Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HLA-H
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HLA-H
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HLA: Histocompatibility complex

    Selected InterPro protein domains (see all 9):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P01893

    ProtoNet protein and cluster: P01893

    3 Blocks protein domains:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type
    IPB010579 MHC_I


    UniProtKB/Swiss-Prot: HLAH_HUMAN, P01893
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    HLA-H for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HLAH_HUMAN, P01893
    Function: Involved in the presentation of foreign antigens to the immune system

         Genatlas biochemistry entry for HLA-H:
    HLA class I-like gene H,5.4 Hind III fragment,see HFEC@,MHC1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042605peptide antigen binding IEA--
         
    HLA-H for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HLA-H
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HLA-H

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HLA-H
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HLA-H

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat HLA-H using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HLA-H
    SwitchGear 3'UTR luciferase reporter plasmidHLA-H 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HLA-H
    Predesigned siRNA for gene silencing in human, mouse, rat HLA-H

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HLA-H

    Clone
    Products:
         
    OriGene clones in human, mouse for HLA-H (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for HLA-H
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-H
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HLA-H

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HLA-H
    Browse ESI BIO Cell Lines and PureStem Progenitors for HLA-H 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-H


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HLAH_HUMAN, P01893: Cell membrane; Single-pass membrane protein (Potential)

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane NAS6461010
    GO:0042612MHC class I protein complex IEA--

    HLA-H for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HLA-H About    
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Proteasome Degradation0.57


    1 BioSystems Pathway for HLA-H
        Proteasome Degradation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HLA-H
    Interactions:

        Search GeneGlobe Interaction Network for HLA-H

    1 Interacting protein for HLA-H (P018933) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SQSTM1Q135013I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001916positive regulation of T cell mediated cytotoxicity IEA--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I IEA--
    GO:0006955immune response NAS6461010

    HLA-H for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HLA-H (HLAH)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000383620(uc021ytv.1 uc021ytw.1 uc021ytx.1) ENST00000383326(uc010jro.3)


    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HLA-H using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HLA-H
    SwitchGear 3'UTR luciferase reporter plasmidHLA-H 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HLA-H
    Predesigned siRNA for gene silencing in human, mouse, rat HLA-H
    Clone
    Products:
         
    OriGene clones in human, mouse for HLA-H (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for HLA-H
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-H
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HLA-H
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HLA-H
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-H
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat HLA-H
      Search QuantiTect SYBR Green Assays in human, mouse, rat HLA-H
      QuantiFast Probe-based Assays in human, mouse, rat HLA-H

    Selected AceView cDNA sequences (see all 1003):

    AI300791 AW236295 BG403212 BM809651 AA487158 BQ690219 F01809 CA417368 
    AI685484 AW337407 AI719030 AI093174 BG698804 BQ052716 BM989102 CA392795 
    AI382604 CF552473 AA377133 BX538084 AI204037 AW402463 AI818330 BQ717597 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HLA-H expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HLA-H Expression
    About this image

    HLA-H Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HLA-H Protein Expression
        Custom PCR Arrays for HLA-H
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HLA-H
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-H
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat HLA-H
    Search QuantiTect SYBR Green Assays in human, mouse, rat HLA-H
    QuantiFast Probe-based Assays in human, mouse, rat HLA-H
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-H

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus
      --

    ENSEMBL Gene Tree for HLA-H (if available)
    TreeFam Gene Tree for HLA-H (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HLA-H gene
    Selected SIMAP similar genes for HLA-H using alignment to 2 protein entries:     HLAH_HUMAN (see all proteins) (see all similar genes):
    HLA-A*0201V3    HLA-ABC    HLA-B*27    B-1510    DKFZp686N10220    HLA-A*01
    HLA-A24AK    HLA-B41    HLA-Cw3    HLA-B27    HLA-B52    B*56
    Cw    HLA B    HLA C*    HLA-A*02    HLA-A*0226    HLA-A*2410

    HLA-H for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HLA-H (see all 447)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2011355691,2
    --29853419(+) AAAAA-/AAAT  
            
    AGCCA
    1 -- us2k10--------
    rs1120088321,2
    C--29853421(+) AAAAAT/ATAGCC 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs285331231,2
    --29853423(+) AAAATG/AGCCAA 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs16115971,2
    C,F,H--29853430(+) CCAAGC/TGTAGT 1 -- us2k13Minor allele frequency- T:0.33NA 6
    rs563893011,2
    --29853434(+) GCGTAC/GTGGCG 1 -- us2k10--------
    rs25238021,2
    C,F,A,H--29853438(-) CACCCA/C/GCCACT 1 -- us2k12NA 4
    rs1123494291,2
    C--29853449(+) CCTGTG/AGTCCC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs28939921,2
    C--29853494(+) GAACCT/CGGGAG 1 -- us2k15Minor allele frequency- C:0.00NA WA CSA 9
    rs45246311,2
    C--29853514(+) GCAGTG/AAGCCG 1 -- us2k18Minor allele frequency- A:0.32NA WA CSA 249
    rs92591721,2
    C--29853526(+) GATCCG/CGCCAC 1 -- us2k17Minor allele frequency- C:0.34NA WA CSA 247

    HapMap Linkage Disequilibrium report for HLA-H (29855350 - 29858856 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HLA-H (see all 67):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv7e195CNV Deletion20811451
    esv2670487CNV Deletion23128226
    dgv1039e201CNV Deletion23290073
    esv2665698CNV Deletion23128226
    esv3124CNV Deletion18987735
    dgv1087e199CNV Deletion23128226
    esv2731772CNV Deletion23290073
    esv2422126CNV Deletion20811451
    dgv1086e199CNV Deletion23128226
    nsv820564CNV Deletion20802225

    Locus Specific Mutation Databases (LSDB): HLA-H

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HLA-H
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-H

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601155    OMIM disorders: --

    11 diseases for HLA-H:    
    About MalaCards
    microvascular complications of diabetes 7    hemochromatosis    porphyria cutanea tarda    variegate porphyria
    hfe-associated hereditary hemochromatosis    alzheimer's disease    porphyria    crohn's disease
    hepatitis b    hepatitis    leukemia


    HLA-H for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): HLA-H
    Human Genome Epidemiology (HuGE) Navigator: HLA-H (3360 documents)

    Export disorders for HLA-H gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HLA-H gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with HLA-H)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transcription analysis, physical mapping, and molecular characterization of a nonclassical human leukocyte antigen class I gene. (PubMed id 2294403)1, 3, 9 Chorney M.J....Weissman S.M. (Mol. Cell. Biol. 1990)
    2. Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation. (PubMed id 15350465)1, 4 Kotzampasaki E.M....Stavropoulos-Giokas C. (Transplant. Proc. 2004)
    3. [Role of polymorphic adhesion molecules in the development of graft-versus-leukemia effect after HLA-matched allogeneic stem cell transplantation]. (PubMed id 15359910)1, 4 Shiobara S....Nakao S. (Rinsho Ketsueki 2004)
    4. Examination of four HLA class I pseudogenes. Common events in the evolution of HLA genes and pseudogenes. (PubMed id 1517564)1, 3 Geraghty D.E....Hansen J.A. (J. Immunol. 1992)
    5. Exon/intron organization and complete nucleotide sequence of an HLA gene. (PubMed id 6461010)1, 2 Malissen M.... Jordan B.R. (Proc. Natl. Acad. Sci. U.S.A. 1982)
    6. HLA-H: a pseudogene with increased variation due to balancing selection at neighboring loci. (PubMed id 9866194)1, 9 Grimsley C....Ober C. (Mol. Biol. Evol. 1998)
    7. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (PLoS Genet. 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    10. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3136 HGNC: 4965 AceView: HLA-EandRANP1andFLJ45422 Ensembl:ENSG00000206341 euGenes: HUgn3136
    ECgene: HLA-H H-InvDB: HLA-H

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0223

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HLA-H Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HLA-H gene:
    Search GeneIP for patents involving HLA-H

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HLA-H  
     OriGene qPCR primer pairs and template standards for HLA-H   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HLA-H  
     OriGene qSTAR qPCR primer pairs in human, mouse for HLA-H   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HLA-H   OriGene Custom Protein Services for HLA-H  

     
     
     Block miRNA regulation of human, mouse, rat HLA-H using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HLA-H
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-H Predesigned siRNA for gene silencing in human, mouse, rat HLA-H
     QuantiFast Probe-based Assays in human, mouse, rat HLA-H Search QuantiTect SYBR Green Assays in human, mouse, rat HLA-H
     Custom PCR Arrays for HLA-H Search Chromatin IP Primers for HLA-H
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat HLA-H Search GeneGlobe Interaction Network for HLA-H
     Regulatory tfbs in HLA-H promoter
     GenScript Custom Purified and Recombinant Proteins Services for HLA-H GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for HLA-H
     GenScript Custom Assay Services for HLA-H GenScript Custom overexpressing Cell Line Services for HLA-H
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HLA-H (HLAH)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HLA-H antibodies
     Antibodies for HLA-H
     See all of Abcam's Antibodies, Kits and Proteins for HLA-H
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for HLA-H
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-H
     SwitchGear 3'UTR luciferase reporter plasmids for HLA-H
     SwitchGear Promoter luciferase reporter plasmids for HLA-H
     Search ThermoFisher Antibodies for HLA-H
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HLA-H
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HLA-H
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HLA-H
     LSBio Antibodies in human, mouse, rat for HLA-H
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HLA-H gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4