Aliases for HLA-H Gene
Aliases for HLA-H Gene
External Ids for HLA-H Gene
- HGNC: 4965
- Entrez Gene: 3136
- Ensembl: ENSG00000206341
- UniProtKB: P01893
Previous GeneCards Identifiers for HLA-H Gene
- GC06P029926
- GC06M029910
- GC06P029962
- GC06P029963
- GC06P029912
- GC06Pf29990
- GC06P029858
- GC06P029655
- GC06P030063
- GC06P030178
- GC06P030087
- GC06P030099
- GC06P030340
- GC06P030485
- GC06P030686
Summaries for HLA-H Gene
-
This major histocompatibility complex gene represents a transcribed pseudogene, possibly derived from HLA-A. This gene displays extensive variation. [provided by RefSeq, May 2010]
GeneCards Summary for HLA-H Gene
HLA-H (Major Histocompatibility Complex, Class I, H (Pseudogene)) is a Pseudogene. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Interferon gamma signaling. GO annotations related to this gene include peptide antigen binding and beta-2-microglobulin binding.
UniProtKB/Swiss-Prot for HLA-H Gene
-
Involved in the presentation of foreign antigens to the immune system.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-H Gene
Genomics for HLA-H Gene
Regulatory Elements for HLA-H Gene
Enhancers for HLA-H Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HLA-H on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HLA-H Gene
- Chromosome:
- 6
- Start:
- 29,887,752 bp from pter
- End:
- 29,891,080 bp from pter
- Size:
- 3,329 bases
- Orientation:
- Plus strand
Genomic View for HLA-H Gene
Genes around HLA-H on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by Ensembl
- 6p22.1 by Entrez Gene
- 6p22.1 by HGNC
HLA-H Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HLA-H Gene
Proteins for HLA-H Gene
-
Protein details for HLA-H Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P01893-HLAH_HUMAN
- Recommended name:
- Putative HLA class I histocompatibility antigen, alpha chain H
- Protein Accession:
- P01893
Protein attributes for HLA-H Gene
- Size:
- 362 amino acids
- Molecular mass:
- 40892 Da
- Quaternary structure:
-
- Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).
- SequenceCaution:
-
- Sequence=AAA36218.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for HLA-H Gene
Post-translational modifications for HLA-H Gene
- Glycosylation at posLast=110110
Antibody Products
-
Abcam antibodies for HLA-H
- Invitrogen Antibodies for HLA-H
- Search GeneTex for Antibodies for HLA-H
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HLA-H
- Origene Custom Protein Services for HLA-H
- Search GeneTex for Proteins for HLA-H
Assay Products
No data available for DME Specific Peptides for HLA-H Gene
Domains & Families for HLA-H Gene
Gene Families for HLA-H Gene
Protein Domains for HLA-H Gene
Suggested Antigen Peptide Sequences for HLA-H Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P01893- Family:
-
- Belongs to the MHC class I family.
Function for HLA-H Gene
Molecular function for HLA-H Gene
- GENATLAS Biochemistry:
- HLA class I-like gene H,5.4 Hind III fragment,see HFEC@,MHC1
- UniProtKB/Swiss-Prot Function:
- Involved in the presentation of foreign antigens to the immune system.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | receptor binding | IBA | -- |
| GO:0030881 | beta-2-microglobulin binding | IMP | 9162021 |
| GO:0042605 | peptide antigen binding | IBA | -- |
Phenotypes for HLA-H Gene
- GenomeRNAi human phenotypes for HLA-H:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Search ViGene Biosciences for HLA-H
CRISPR Products
- Browse CRISPR knockouts for HLA-H
miRNA Products
- Search ViGene Biosciences for HLA-H
Inhibitory RNA Products
- Search ViGene Biosciences for HLA-H
Cell Line Products
- Search ViGene Biosciences for HLA-H
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HLA-H Gene
Localization for HLA-H Gene
Subcellular locations from UniProtKB/Swiss-Prot for HLA-H Gene
- Cell membrane; Single-pass membrane protein.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | NAS | 6461010 |
| GO:0009986 | cell surface | IMP | 9162021 |
| GO:0012507 | ER to Golgi transport vesicle membrane | TAS | -- |
No data available for Subcellular locations from COMPARTMENTS for HLA-H Gene
Pathways & Interactions for HLA-H Gene
Pathways by source for HLA-H Gene
1 BioSystems pathway for HLA-H Gene
Interacting Proteins for HLA-H Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent | TAS | -- |
| GO:0006955 | immune response | NAS | 6461010 |
| GO:0043312 | neutrophil degranulation | TAS | -- |
No data available for SIGNOR curated interactions for HLA-H Gene
Transcripts for HLA-H Gene
mRNA/cDNA for HLA-H Gene
- (8) Additional mRNA sequences :
- (1003) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HLA-H Gene
CRISPR Products
- Browse CRISPR knockouts for HLA-H
miRNA Products
- Search ViGene Biosciences for HLA-H
Inhibitory RNA Products
- Search ViGene Biosciences for HLA-H
Flow Cytometry Products
Expression for HLA-H Gene
mRNA differential expression in normal tissues according to GTEx for HLA-H Gene
This gene is overexpressed in Whole Blood (x7.1).
This gene is overexpressed in Lavage (30.1), Blymphocyte (20.0), and Urine (13.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HLA-H Gene
SOURCE GeneReport for Unigene cluster for HLA-H Gene:
Hs.728808Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-H Gene
Orthologs for HLA-H Gene
No data available for Orthologs for HLA-H Gene
Paralogs for HLA-H Gene
(113) SIMAP similar genes for HLA-H Gene using alignment to 2 proteins:
- HLA-A*0201V3
- HLA-ABC
- HLA-B*27
- HLA-A*01
- HLA-Cw3
- HLA-B41
- HLA-A24AK
- DKFZp686N10220
- B-1510
- HLA-B27
- HLA-B52
- MHC class I HLA-A
- HLA-Bw62.5
- HLA-Bw62.4
- HLA-Bw62.3
- HLA-Bw62.1
- HLA-B*51IM
- HLA-B*5101 variant
- HLA-B*1513
- HLA-B*07ML
- HLA-A*2410
- HLA-A*0226
- HLA-A*02
- HLA C*
- HLA B
- Cw
- B*56
- MHC
- HLA-Cw*
- HLA-B57
- HLA-B51
- HLA-B*5603
- HLA-B*4202
- HLA-B*40
- HLA-B*3531
- HLA-B*3512
- HLA-B*0707
- HLA-A*33
- B-3501
- HLA
- HLA-B
- HLA-B35
- HLA-B*47RG
- HLAC
- HLA-A*31
- HLA-Cw*02023
- HLA-B52v
- HLA-B1501V2
- HLA-B15
- HLA-B*5501 variant
- HLA-B*4012
- HLA-B*2712
- HLA-B*15UL
- HLA-B*15MD
- HLA-B*15IL
- HLA-B*1522
- HLA-B*13
- HLA-B gene
- HLA-All
- HLA-A
- HLA-Cw2
- HLA-Cw*15P
- HLA-Cw*03MAC
- HLA-B*58
- HLA-B*35SRE
- HLA-B*35KM
- HLA-B*18 variant
- HLA-A null
- HLA G locus
- B*35
- B*15
- HLA-Cw
- HLA-B18
- HLA-B*35JAC
- HLA-A*03
- HLA-C
- HLA-G
- HLA-F
- HLC-C
- HLA-Cw*03
- HLA-B*1805
- HLA -B
- EA2.1
- Cw*03
- HLA-E
- HLA-CW
- HLA-A*24
- MHC-G
- HLA-G3
- HLA-Cw*0707
- HLA-Cw*07
- HLA-A2
- HLA-A*0225
- Cw*08
- HLA-B*
- HLA-J
- DKFZp686P19218
- LOC554223
- HLA-A26
- EA1.2
- FLJ45422
- HLA-DQB1
- HLA-DRB1
- MR1
- HLA-G2.2
- HFE
- HLA-DMB
- MICA
- MICB
- HLA-MICA
- AZGP1
- HLA-DQB
- HLA-DRB4
No data available for Paralogs for HLA-H Gene
Variants for HLA-H Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1003201635 | -- | 29,886,276(+) | CATAT(A/G)CTCAC | upstream-variant-2KB | |
| rs1004239479 | -- | 29,889,203(+) | TGTTG(C/T)CTGGG | intron-variant | |
| rs1007799530 | -- | 29,886,621(+) | TGCAG(A/G)ATGTC | upstream-variant-2KB | |
| rs1016952498 | -- | 29,890,649(+) | TTTCT(A/G)TAGTG | intron-variant | |
| rs1017437530 | -- | 29,887,784(+) | CTCCT(C/G)CTGCT | nc-transcript-variant |
Relevant External Links for HLA-H Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HLA-H
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HLA-H Gene
Disorders for HLA-H Gene
Relevant External Links for HLA-H
No disorders were found for HLA-H Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HLA-H Gene
Publications for HLA-H Gene
- Transcription analysis, physical mapping, and molecular characterization of a nonclassical human leukocyte antigen class I gene. (PMID: 2294403) Chorney M.J. … Weissman S.M. (Mol. Cell. Biol. 1990) 2 3 22 64
- Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation. (PMID: 15350465) Kotzampasaki E.M. … Stavropoulos-Giokas C. (Transplant. Proc. 2004) 3 46 64
- [Role of polymorphic adhesion molecules in the development of graft-versus-leukemia effect after HLA-matched allogeneic stem cell transplantation]. (PMID: 15359910) Shiobara S. … Nakao S. (Rinsho Ketsueki 2004) 3 46 64
- HLA-H: a pseudogene with increased variation due to balancing selection at neighboring loci. (PMID: 9866194) Grimsley C. … Ober C. (Mol. Biol. Evol. 1998) 3 22 64
- Examination of four HLA class I pseudogenes. Common events in the evolution of HLA genes and pseudogenes. (PMID: 1517564) Geraghty D.E. … Hansen J.A. (J. Immunol. 1992) 2 3 64
Products for HLA-H Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HLA-H
- Origene Custom Protein Services for HLA-H
- Browse OriGene Inhibitory RNA Products For HLA-H
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for HLA-H
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HLA-H
- GenScript: Custom all cDNA clones Services for HLA-H
- GenScript Custom Purified and Recombinant Proteins Services for HLA-H
- GenScript Custom Assay Services for HLA-H
- GenScript Custom overexpressing Cell Line Services for HLA-H
- Browse GenScript CRISPR for HLA-H
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HLA-H
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for HLA-H
- Search ViGene Biosciences for HLA-H
- Cyagen custom Knockout/knockin (KOKI) mouse models for HLA-H
- VectorBuilder custom plasmid, inducible vectors for HLA-H
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HLA-H
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HLA-H Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer