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Aliases &
Descriptions
for HLA-H
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| HFE 5 | | HFE1 5 | | HLA-12.4 3 | | HLA-AR 3 | | HLAH 3 | | HLAHP 2 | | MVCD7 5 |
| | | Descriptions |
|---|
| major histocompatibility complex, class I, H (pseudogene) 2 |
|
| |
Search outside databases for aliases for HLA-H genePrevious GC identifers: GC06P029926 GC06M029910 GC06P029962 GC06P029912 GC06Pf29990 |
Summaries
for HLA-H(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: HLAH_HUMAN, P01893Function: Involved in the presentation of foreign antigens to the immune system |
Genomic Location
for HLA-H
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the HLA-H gene 
Entrez Gene cytogenetic band: 6p21.3 HGNC cytogenetic band: 6p21.3HLA-H Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P029963:
(about GC identifiers)
Start:
|
29,963,508 bp from pter |
End:
|
29,966,245 bp from pter |
Size:
|
2,738 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000006.10 NT_007592.14 NT_113891.1 NT_113893.1
| Proteins
for HLA-H
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: HLAH_HUMAN, P01893 (See
protein sequence)Recommended Name: Putative HLA class I histocompatibility antigen, alpha chain H precursor Size: 362 amino acids; 40850 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin)
Subcellular location: Cell membrane; Single-pass membrane protein (Potential)
Caution: Could be the product of a pseudogenePost-translational modifications:
View phosphorylation sites using PhosphoSite2
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for HLA-H:
Assays for HLA-H: | Protein
Domains/
Families
for HLA-H(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P01893
ProtoNet protein and cluster: P01893 3 Blocks protein families: IPB001039 MHC class I signature IPB003597 Immunoglobulin C-type IPB010579 MHC_I
UniProtKB/Swiss-Prot: HLAH_HUMAN, P01893Similarity: Belongs to the MHC class I familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain | Gene Function
for HLA-H
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NR_001434
 Applied Biosystems Silencer® siRNAs for HLA-H
 Browse siRNA at Sigma-Aldrich
Browse shRNA at Sigma-Aldrich
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NR_001434
Myc/DDK tagged cDNA clone in CMV expression vector: NR_001434
untagged cDNA clone in CMV expression vector: NR_001434
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NR_001434
UniProtKB/Swiss-Prot: HLAH_HUMAN, P01893Function: Involved in the presentation of foreign antigens to the immune systemGenatlas biochemistry entry for HLA-H:HLA class I-like gene H,5.4 Hind III fragment,see HFEC@,MHC11 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0032393 | MHC class I receptor activity |
NAS | 6461010 |
About this table | Pathways & Interactions
for HLA-H
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
--3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I |
IEA | -- | | GO:0006955 | immune response |
NAS | 6461010 | | GO:0019882 | antigen processing and presentation |
IEA | -- |
About this table
|
Drugs & Compounds
for HLA-H(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for HLA-H
|
Transcripts
for HLA-H(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NR_001434
Browse siRNA at Sigma-Aldrich
Browse shRNA at Sigma-Aldrich
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NR_001434
Myc/DDK tagged cDNA clone in CMV expression vector: NR_001434
untagged cDNA clone in CMV expression vector: NR_001434
Additional cDNA sequence: AK090500.1 AK293556.1 AK299998.1 AK300878.1 AK308374.1 AK309163.1 AK309480.1 CR594843.1 24/48 DOTS entries (see all 48
): DT.100058894 DT.100733433 DT.100733427 DT.121345984 DT.100849442 DT.95378900 DT.86995001 DT.91787286 DT.91911697 DT.95333141 DT.95376642 DT.95376774 DT.100733374 DT.100855576 DT.95338475 DT.100733406 DT.100733440 DT.91783956 DT.92045303 DT.95090280 DT.95223958 DT.98083731 DT.100042764 DT.100044088 24/1003 AceView cDNA sequences (see all 1003
):CD368526 BM469085 AI093174 CB120660 AA487158 AI418980 AW945358 BM912883 BQ685739 T62022 AJ293263 AI367775 AI143817 AU279942 BQ940569 BX421485 BX439073 AW236295 CA439069 F05537 BU615957 BQ063518 BP339168 AI271725
 highest scoring ESTs for HLA-H:CA435535 AA360672 BG956462 Unigene Cluster for HLA-H: Major histocompatibility complex, class I, H (pseudogene) Hs.655226 [show with all ESTs]Unigene Representative Sequence: AK090500
GeneLoc Exon Structure
|
Expression
for HLA-H
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HLA-H expression in normal and diseased human tissues
1 / 3Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.655226
|
Orthologs
for HLA-H
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
--
| Paralogs
for HLA-H(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
SNPs/Variants
for HLA-H(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| -- |
Disorders & Mutations
for HLA-H
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 235200 Genetic Association Database: HLA-H
Human Genome Epidemiology Navigator: HLA-H (2607 documents)
|
Medical News
for HLA-H(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications
for HLA-H (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/15 PubMed articles for HLA-H gene (see all 15
):- Transcription analysis, physical mapping, and molecular characterization of a nonclassical human leukocyte antigen class I gene. (PubMed id 2294403)1, 2, 3 Chorney M.J....Weissman S.M. (1990)
- Minor histocompatibility antigen HA-1 and HPA-5 polymorphisms in HLA-identical related bone marrow transplantation. (PubMed id 15350465)3, 6 Kotzampasaki E.M....Stavropoulos-Giokas C. (2004)
- [Role of polymorphic adhesion molecules in the development of graft-versus-leukemia effect after HLA-matched allogeneic stem cell transplantation] (PubMed id 15359910)3, 6 Shiobara S....Nakao S. (2004)
- Examination of four HLA class I pseudogenes. Common events in the evolution of HLA genes and pseudogenes. (PubMed id 1517564)2, 3 Geraghty D.E....Hansen J.A. (1992)
- Exon/intron organization and complete nucleotide sequence of an HLA gene. (PubMed id 6461010)3, 4 Malissen M.... Jordan B.R. (1982)
- HLA-H: a pseudogene with increased variation due to balancing selection at neighboring loci. (PubMed id 9866194)1, 3 Grimsley C....Ober C. (1998)
- Phosphoproteome of resting human platelets. (PubMed id 18088087)4 Zahedi R.P.... Sickmann A. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- HLA-AR, an inactivated antigen-presenting locus related to HLA-A. Implications for the evolution of the MHC. (PubMed id 2329283)3 Zemmour J....Parham P. (1990)
- A class I jumping clone places the HLA-G gene approximately 100 kilobases from HLA-H within the HLA-A subregion of the human MHC. (PubMed id 1916822)1 Shukla H....Chorney M.J. (1991)
|
Search for HLA-H
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HLA-H
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HLA-H
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HLA-H(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for HLA-H(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for HLA-H:
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