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HLA-G Gene(Protein Coding)

Major Histocompatibility Complex, Class I, G

GCID:
GC06P030845
GIFtS:
63
Genes Participants
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Aliases for HLA-G Gene

Aliases for HLA-G Gene

  • Major Histocompatibility Complex, Class I, G 2 3 5
  • HLA-G Histocompatibility Antigen, Class I, G 2 3
  • MHC Class I Antigen G 3 4
  • B2 Microglobulin 2 3
  • HLA G Antigen 3 4
  • HLA Class I Histocompatibility Antigen, Alpha Chain G 3
  • HLA-6.0 4
  • MHC-G 3
  • HLAG 4

External Ids for HLA-G Gene

Previous GeneCards Identifiers for HLA-G Gene

  • GC06P029852
  • GC06P029565
  • GC06P029904
  • GC06P029906
  • GC06P029907
  • GC06P029913
  • GC06P029598
  • GC06P029794
  • GC06P030042
  • GC06P030088
  • GC06P030330
  • GC06P030482
  • GC06P030683

Summaries for HLA-G Gene

Entrez Gene Summary for HLA-G Gene

  • HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-G Gene

HLA-G (Major Histocompatibility Complex, Class I, G) is a Protein Coding gene. Diseases associated with HLA-G include Asthma Susceptibility, Hla-G-Related and Severe Pre-Eclampsia. Among its related pathways are Allograft rejection and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. GO annotations related to this gene include protein homodimerization activity and peptide antigen binding. An important paralog of this gene is HLA-A.

UniProtKB/Swiss-Prot for HLA-G Gene

  • Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.

Gene Wiki entry for HLA-G Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-G Gene

Genomics for HLA-G Gene

Products:

  1. Regulatory Element

Regulatory Elements for HLA-G Gene

Enhancers for HLA-G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G029940 1.3 ENCODE dbSUPER 59.3 +115.3 115294 3.7 HDGF PKNOX1 FOXA2 WRNIP1 ZFP64 ARID4B DMAP1 ZNF2 YY1 ZNF143 HLA-J HLA-T HLA-G HLA-H HLA-W HLA-K HLA-A HCG4P3 ZFP57 HLA-U
GH06G029945 0.8 ENCODE dbSUPER 60.9 +118.0 118032 0.2 SOX5 ELF3 WRNIP1 NR2F6 RARA HLA-G HLA-J HLA-K HLA-H ZNRD1 PIR61557 HCG4P4
GH06G029946 0.6 ENCODE dbSUPER 58.5 +119.6 119572 0.3 POLR2A HLA-J HLA-G HLA-A HCG4P5 HLA-K ZNRD1 PIR61557 HCG4P4
GH06G029944 0.5 ENCODE dbSUPER 60.1 +117.5 117472 0.2 HLA-J HLA-G HLA-H ZNRD1 HLA-A PIR61557 HCG4P4
GH06G029948 0.7 ENCODE dbSUPER 40.6 +120.1 120077 0.1 POLR2A SMAD5 RBFOX2 HLA-G HCG4P3 HLA-K PIR61557 HCG4P4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HLA-G on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the HLA-G gene promoter:

Genomic Location for HLA-G Gene

Chromosome:
6
Start:
29,826,967 bp from pter
End:
29,831,125 bp from pter
Size:
4,159 bases
Orientation:
Plus strand

Genomic View for HLA-G Gene

Genes around HLA-G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-G Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HLA-G Gene

Proteins for HLA-G Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HLA-G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17693-HLAG_HUMAN
    Recommended name:
    HLA class I histocompatibility antigen, alpha chain G
    Protein Accession:
    P17693

    Protein attributes for HLA-G Gene

    Size:
    338 amino acids
    Molecular mass:
    38224 Da
    Quaternary structure:
    • Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Homodimer; disulfide-linked. Binds to LILRB1 and LILRB2.

    Three dimensional structures from OCA and Proteopedia for HLA-G Gene

neXtProt entry for HLA-G Gene

Protein Expression for HLA-G Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HLA-G Gene

  • Glycosylation at posLast=110110
  • Modification sites at PhosphoSitePlus

Other Protein References for HLA-G Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for HLA-G

No data available for DME Specific Peptides for HLA-G Gene

Domains & Families for HLA-G Gene

Gene Families for HLA-G Gene

HGNC:

Protein Domains for HLA-G Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HLA-G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17693

UniProtKB/Swiss-Prot:

HLAG_HUMAN :
  • Belongs to the MHC class I family.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with HLA-G: view

Function for HLA-G Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for HLA-G Gene

GENATLAS Biochemistry:
HLA class Ib ,6.0kb Hind III fragment,expressed in trophoblast (see MHC1),including a 5 locus control region (see LCR- HLA-G)
UniProtKB/Swiss-Prot Function:
Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.

Gene Ontology (GO) - Molecular Function for HLA-G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20702625
GO:0042605 peptide antigen binding IBA --
GO:0042803 protein homodimerization activity NAS,IDA 18550825
genes like me logo Genes that share ontologies with HLA-G: view
genes like me logo Genes that share phenotypes with HLA-G: view

Animal Models for HLA-G Gene

MGI Knock Outs for HLA-G:

Animal Model Products

miRNA for HLA-G Gene

miRTarBase miRNAs that target HLA-G

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HLA-G Gene

Localization for HLA-G Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-G Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLA-G gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
endosome 5
golgi apparatus 4
extracellular 2
nucleus 2
cytosol 2
mitochondrion 1
lysosome 1

Gene Ontology (GO) - Cellular Components for HLA-G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005886 plasma membrane TAS --
GO:0012507 ER to Golgi transport vesicle membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HLA-G: view

Pathways & Interactions for HLA-G Gene

genes like me logo Genes that share pathways with HLA-G: view

Interacting Proteins for HLA-G Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000353472%0d%0a9606.ENSP00000452780%0d%0a9606.ENSP00000354566%0d%0a9606.ENSP00000228928%0d%0a9606.ENSP00000369299%0d%0a9606.ENSP00000318472%0d%0a
Selected Interacting proteins: P17693-HLAG_HUMAN ENSP00000353472 for HLA-G Gene via MINT STRING IID

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
HLA-DRB1
LILRB1

SIGNOR curated interactions for HLA-G Gene

Activates:

Gene Ontology (GO) - Biological Process for HLA-G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS --
GO:0002645 positive regulation of tolerance induction IMP 22802125
genes like me logo Genes that share ontologies with HLA-G: view

Drugs & Compounds for HLA-G Gene

Products:

  1. Drug

(14) Drugs for HLA-G Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1551
Capecitabine Approved, Investigational Pharma RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1342
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1856
hmg coa reductase inhibitors Pharma 0

(16) Additional Compounds for HLA-G Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HLA-G: view

Transcripts for HLA-G Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for HLA-G Gene

(4) REFSEQ mRNAs :
(28) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HLA-G Gene

Major histocompatibility complex, class I, G:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-G Gene

No ASD Table

Relevant External Links for HLA-G Gene

GeneLoc Exon Structure for
HLA-G
ECgene alternative splicing isoforms for
HLA-G

Expression for HLA-G Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HLA-G Gene

mRNA expression in normal human tissues for HLA-G Gene
mRNA expression by BioGPS for HLA-G GenemRNA expression by GTEx for HLA-G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-G Gene

This gene is overexpressed in Pituitary (x12.0), Whole Blood (x6.7), Lung (x4.2), and Testis (x4.1).

Protein differential expression in normal tissues from HIPED for HLA-G Gene

This gene is overexpressed in Skin (29.9) and Blymphocyte (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HLA-G Gene



SOURCE GeneReport for Unigene cluster for HLA-G Gene:

Hs.512152

mRNA Expression by UniProt/SwissProt for HLA-G Gene:

P17693-HLAG_HUMAN
Tissue specificity: Expressed in trophoblasts.

Evidence on tissue expression from TISSUES for HLA-G Gene

  • Eye(4.3)
  • Blood(3)
  • Heart(2.7)
  • Kidney(2.6)
  • Intestine(2.5)
  • Liver(2.5)
  • Muscle(2.3)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with HLA-G: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-G Gene

Orthologs for HLA-G Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for HLA-G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia PATR-G 34
  • 98.95 (n)
-- 35
  • 68 (a)
 ManyToMany
rat
(Rattus norvegicus)
 Mammalia RT1-M3-1 34
  • 72.33 (n)
mouse
(Mus musculus)
 Mammalia H2-M3 34 16
  • 71.41 (n)
Species where no ortholog for HLA-G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HLA-G Gene

ENSEMBL:
Gene Tree for HLA-G (if available)
TreeFam:
Gene Tree for HLA-G (if available)

Paralogs for HLA-G Gene

Paralogs for HLA-G Gene

(117) SIMAP similar genes for HLA-G Gene using alignment to 101 proteins:

Pseudogenes.org Pseudogenes for HLA-G Gene

genes like me logo Genes that share paralogs with HLA-G: view

Variants for HLA-G Gene

Sequence variations from dbSNP and Humsavar for HLA-G Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000079385 -- 29,825,524(+) GAGGG(A/T)TTCAG upstream-variant-2KB
rs1000877756 -- 29,831,200(+) CTCAG(A/G)CCACC downstream-variant-500B
rs1001243158 -- 29,825,095(+) GTGCT(A/G)GGATT upstream-variant-2KB
rs1001428984 -- 29,830,835(+) ACTCC(C/T)CTTTG downstream-variant-500B, utr-variant-3-prime
rs1004181336 -- 29,829,356(+) TCCAG(C/G/T)TGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HLA-G Gene

Variant ID Type Subtype PubMed ID
dgv1086e199 CNV deletion 23128226
dgv3467e59 CNV duplication 20981092
dgv3468e59 CNV duplication 20981092
dgv992e201 CNV deletion 23290073
esv25966 CNV gain+loss 19812545
esv2665698 CNV deletion 23128226
esv2670487 CNV deletion 23128226
esv2731772 CNV deletion 23290073
esv2731775 CNV deletion 23290073
esv2759412 CNV gain+loss 17122850
esv3332677 CNV duplication 20981092
esv3420260 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv428139 CNV gain 18775914
nsv950149 CNV deletion 24416366
nsv965702 CNV duplication 23825009

Variation tolerance for HLA-G Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.44; 81.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HLA-G Gene

Human Gene Mutation Database (HGMD)
HLA-G
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HLA-G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-G Gene

Disorders for HLA-G Gene

MalaCards: The human disease database

(16) MalaCards diseases for HLA-G Gene - From: OMIM, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma susceptibility, hla-g-related
  • asthma, susceptibility to
severe pre-eclampsia
  • antepartum severe pre-eclampsia
vaginal cancer
  • malignant neoplasm of vagina
choriocarcinoma
  • chorioepithelioma
asthma
  • asthma, protection against
- elite association - COSMIC cancer census association via MalaCards
Search HLA-G in MalaCards View complete list of genes associated with diseases

Relevant External Links for HLA-G

Genetic Association Database (GAD)
HLA-G
Human Genome Epidemiology (HuGE) Navigator
HLA-G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HLA-G
genes like me logo Genes that share disorders with HLA-G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HLA-G Gene

Publications for HLA-G Gene

  1. The genetic structure of 3'untranslated region of the HLA-G gene: polymorphisms and haplotypes. (PMID: 19798077) Castelli E.C. … Donadi E.A. (Genes Immun. 2010) 3 22 46 64
  2. A study of HLA-G polymorphism and linkage disequilibrium in renal transplant patients and their donors. (PMID: 18926911) Pirri A. … Bicalho M.d.a. .G. (Transpl. Immunol. 2009) 3 22 46 64
  3. HLA-G genotype and HLA-G expression in systemic lupus erythematosus: HLA-G as a putative susceptibility gene in systemic lupus erythematosus. (PMID: 18380776) Rizzo R. … Baricordi O.R. (Tissue Antigens 2008) 3 22 46 64
  4. The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease. (PMID: 17446213) Glas J. … Weiss E.H. (Int. Immunol. 2007) 3 22 46 64
  5. [Expression of human leucocyte antigen G on human placenta and its gene polymorphism in relation to intrahepatic cholestasis of pregnancy]. (PMID: 17961331) Peng B. … Zou H. (Zhonghua Fu Chan Ke Za Zhi 2007) 3 22 46 64

Products for HLA-G Gene

  • Cloud-Clone Corp. Antibodies for HLA-G
  • Cloud-Clone Corp. Proteins for HLA-G
  • Cloud-Clone Corp Assay Kits for HLA-G

Sources for HLA-G Gene

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