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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HLA-G Gene

protein-coding GIFtS: 65
GCID: GC06P029794

major histocompatibility complex, class I, G

(Previous names: HLA-G histocompatibility antigen, class I, G )

Explore 127 diseases affiliated with
HLA-G via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Major Histocompatibility Complex, Class I, G¹ ²		B2 Microglobulin²
HLA-G Histocompatibility Antigen, Class I, G¹ ²		HLA Class I Histocompatibility Antigen, Alpha Chain G²
HLA G Antigen² ³		HLA Class I Molecule²
MHC Class I Antigen G² ³		HLA-6.0³
MHC-G²		HLAG³

External Ids:	HGNC: 4964¹	Entrez Gene: 3135²	Ensembl: ENSG00000204632⁷	OMIM: 142871⁵	UniProtKB: P17693³

Export aliases for HLA-G gene to outside databases

Previous GC identifers: GC06P029852 GC06P029565 GC06P029904 GC06P029906 GC06P029907 GC06P029913 GC06P029598

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HLA-G:

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy

chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on

fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes

the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the

alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. (provided by RefSeq,

Jul 2008)

UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693

Function: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of

the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes,

macrophages and mononuclear cells

Gene Wiki entry for HLA-G

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167245.1 NT_167246.1 NT_167247.1 NT_167248.1

NT_167249.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HLA-G gene promoter:
AP-1 RREB-1 ATF-2 p300 IRF-1 AP-2gamma CREB deltaCREB c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HLA-G promoter sequence

Search SABiosciences Chromatin IP Primers for HLA-G

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-G

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p21.3

HLA-G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-G gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P029794: view genomic region (about GC identifiers)

Start:	29,794,744 bp from pter	End:	29,798,902 bp from pter
Size:	4,159 bases	Orientation:	plus strand

6 alternative locations:

Chr6+,ALT_REF_LOCI_2 29,788,431-29,831,788	Chr6+,ALT_REF_LOCI_4 29,714,745-29,718,887	Chr6+,ALT_REF_LOCI_6 29,791,932-29,831,682
Chr6+,ALT_REF_LOCI_5 29,706,458-29,710,601	Chr6+,ALT_REF_LOCI_3 29,791,968-29,807,161	Chr6+,ALT_REF_LOCI_7 29,721,773-29,725,930

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, alpha chain G precursor

Size: 338 amino acids; 38224 Da

Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Homodimer; disulfide-linked. Binds to

LILRB1 and LILRB2

Subcellular location: Membrane; Single-pass type I membrane protein

6/8 PDB 3D structures from and Proteopedia for HLA-G (see all 8):

1YDP (3D)

2D31 (3D)

2DYP (3D)

3BZE (3D)

3CDG (3D)

3CII (3D)

Explore the universe of human proteins at neXtProt for HLA-G: NX_P17693

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P17693

HLA-G Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002118.1

ENSEMBL proteins:

ENSP00000366024 ENSP00000353472 ENSP00000366014 ENSP00000436375 ENSP00000366011

ENSP00000412927

Reactome Protein details: P17693
Human Recombinant Protein Products:

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	Novus Biologicals HLA-G Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HLA-G

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0012507	ER to Golgi transport vesicle membrane	TAS	--
GO:0030670	phagocytic vesicle membrane	TAS	--
GO:0031901	early endosome membrane	TAS	--

HLA-G for ontologies About GeneDecksing

HLA-G Antibody Products:

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	GenScript Custom Superior Antibodies Services for HLA-G
	Novus Biologicals HLA-G Antibodies
	Abcam antibodies for HLA-G
	Uscn Antibodies for HLA-G
	Search ThermoFisher Antibodies for HLA-G

Assay Products for HLA-G:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HLA-G
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HLA-G

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HLA-G for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR011162 MHC_I/II-like_Ag-recog

IPR013783 Ig-like_fold

IPR003597 Ig_C1-set

IPR007110 Ig-like_dom

IPR003006 Ig/MHC_CS

Graphical View of Domain Structure for InterPro Entry P17693

ProtoNet protein and cluster: P17693

2 Blocks protein families:

IPB001039 MHC class I signature

IPB003597 Immunoglobulin C-type

UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693

Similarity: Belongs to the MHC class I family

Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693

Function: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of

the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes,

macrophages and mononuclear cells

Genatlas biochemistry entry for HLA-G:

HLA class Ib ,6.0kb Hind III fragment,expressed in trophoblast (see MHC1),including a 5' locus control region (see LCR-

HLA-G)

miRNA Products:		miRTarBase miRNAs that target HLA-G: hsa-mir-152 (MIRT000293), hsa-mir-148b (MIRT000295), hsa-mir-148a (MIRT000297)

		OriGene 3'-UTR Clone: HLA-G Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-G
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		SwitchGear 3'UTR luciferase reporter plasmid: HLA-G 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

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		GenScript: all cDNA clones in your preferred vector: HLA-G (NM_002127)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-G

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HLA-G
		Search LifeMap BioReagents cell lines for HLA-G

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HLA-G

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IPI	--
GO:0032393	MHC class I receptor activity	TAS	9539768
GO:0042803	protein homodimerization activity	NAS	18550825

HLA-G for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for HLA-G:

Decreased BPV1 E2 protein expr

Increased HPV18 LCR reporter a

Animal Models:
Mouse knock-out H2-M3^H2-tm1Crw for HLA-G
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for H2-M3):

hematopoietic system

homeostasis/metabolism

immune system

HLA-G for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Translocation of peptide bound MHC class I complex to cell surface

Translocation of peptide bound MHC class I complex to cell surface	1.00	Endosomal/Vacuolar pathway	0.78
Journey of cargo through Golgi complex	1.00	Peptide loading on MHC class I in phagosome	0.70
Expression of peptide bound class I MHC on cell surface	1.00	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	0.28
Export of peptide loaded MHC class I complex to PM	1.00

Allograft rejection

Allograft rejection	1.00	CTL Mediated Apoptosis	0.38
Type I diabetes mellitus	0.67	Viral myocarditis	0.33
Graft-versus-host disease	0.63	Antigen processing and presentation	0.25
Autoimmune thyroid disease	0.60

Ubiquitinated Orc1 is degraded by the proteasome

	ER-Phagosome pathway	0.74			Proteasome Degradation	0.56
	Antigen processing-Cross presentation	0.60

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for HLA-G

Immune response Role of DAP12 receptors in NK cells

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HLA-G

	CDC42 Pathway
	CTL Mediated Apoptosis

1 GeneGo (Thomson Reuters) Pathway for HLA-G

Immune response Role of DAP12 receptors in NK cells

1 BioSystems Pathway for HLA-G

Proteasome Degradation

5/19 Reactome Pathways for HLA-G (see all 19)

	Endosomal/Vacuolar pathway
	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
	Interferon alpha/beta signaling
	Expression of IFN-induced genes
	ER-Phagosome pathway

5/10 Kegg Pathways (Kegg details for HLA-G) (see all 10):

	Endocytosis
	Phagosome
	Cell adhesion molecules (CAMs)
	Antigen processing and presentation
	Natural killer cell mediated cytotoxicity

HLA-G for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HLA-G

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/55 Interacting proteins for HLA-G (P17693^{2, 3} ENSP00000353472⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 55)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LILRB1	Q8NHL6²^,³, ENSP00000315997⁴	MINT-7144982 I2D: score=3 STRING: ENSP00000315997
ENSG00000206505	P30457³, ENSP00000373114⁴	I2D: score=1 STRING: ENSP00000373114
HLA-A	P30457³, ENSP00000366005⁴	I2D: score=1 STRING: ENSP00000366005
B2M	P61769³, ENSP00000340858⁴	I2D: score=3 STRING: ENSP00000340858
CD8A	P01732³, ENSP00000283635⁴	I2D: score=3 STRING: ENSP00000283635

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	TAS	--
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS	--
GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent	TAS	--
GO:0002666	positive regulation of T cell tolerance induction	IMP	--
GO:0002767	immune response-inhibiting cell surface receptor signaling pathway	IDA	--

HLA-G for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HLA-G for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HLA-G
10/27 Novoseek chemical compound relationships for HLA-G gene (see all 27) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
1-methyltryptophan	46.5	1	16236119 (1)
indoleamine	35	6	15878889 (2), 18289708 (2), 19143868 (1), 16129951 (1)
5-aza-2'deoxycytidine	32.3	32	16045815 (4), 18823661 (3), 18498645 (2), 12552087 (1)
neopterin	12.7	5	2129033 (2), 2117484 (1), 1878399 (1)
matrigel	12.5	2	10684818 (2)
ifn-alpha	12.5	1	12183445 (1)
progesterone	7.59	23	19527229 (4), 16210391 (4), 20052552 (2), 18824770 (2) (see all 9)
sodium	4.47	1	12545635 (1)
oxygen	2.05	4	18325889 (1), 16807282 (1)
cholesterol	0.747	1	8079411 (1)

1 PharmGKB related drug/compound annotation for HLA-G gene

Drug/compound	PharmGKB Annotation
methotrexate	CA

About this table

Search CenterWatch for drugs/clinical trials and news about HLA-G / HLAG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HLA-G gene:

NM_002127.5

Unigene Cluster for HLA-G:

Major histocompatibility complex, class I, G

Hs.512152 [show with all ESTs]

Unigene Representative Sequence: AK093478

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000376828(uc003raj.3) ENST00000360323(uc003nnz.3 uc010jrn.2 uc011dmb.2)

ENST00000478355 ENST00000376818 ENST00000478519(uc003nny.3) ENST00000376815(uc003ran.1)

ENST00000428701(uc003nnw.2)

miRNA Products:		OriGene 3'-UTR Clone: HLA-G Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-G
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-G OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-G OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HLA-G (NM_002127)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-G
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-G

Additional cDNA sequence:

AF071017.1 AF071018.1 AF071019.1 AF071020.1 AF071021.1 AF071022.1 AF196177.1 AF196178.1

AF226990.2 AF436089.1 AK093478.1 AK302054.1 AY359818.1 BC021708.2 M32800.1 M90683.1

M90684.1 M90685.1 M90686.1 U58024.1 U58025.1 U58026.1 U58027.1 U58028.1

U58029.1 U58094.1 U88244.1 X17273.1

17 DOTS entries:

DT.100753459 DT.100825997 DT.455506 DT.95158992 DT.100645441 DT.100753462 DT.100809966 DT.100733427

DT.100733440 DT.100855576 DT.100733391 DT.100859573 DT.121345649 DT.315161 DT.91722926 DT.91783937

DT.95338475

24/25 AceView cDNA sequences (see all 25):

CR608458 CR613246 AF071021 M90684 AF226990 M90683 CR623340 CR606159

AF196177 AF071018 X17273 AF196178 AF071020 M90686 AF071017 AF071019

AX748153 M32800 AK093478 U88244 BC021708 M90685 AY359818 AF071022

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HLA-G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

HLA-G expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Umbilical Cord

Wharton's Jelly

Umbilical Cord Mesenchymal Stem Cells

Extraembryonic Tissues, Umbilical Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

Bone marrow-derived adherent progenitor cells (MultiStem) (Adult Stem / Progenitor Cell)

Bone

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

Trophoblast-like cells (Generation of tropho...)

Syncytiotrophoblast-like cells (Generation of syncyt...)

See HLA-G Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HLA-G

SOURCE GeneReport for Unigene cluster: Hs.512152

UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693

Tissue specificity: Expressed in trophoblasts

SABiosciences Expression via Pathway-Focused PCR Array including HLA-G:

Type I Interferon Response in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-G

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HLA-G

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for HLA-G gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NM79_CHICK⁶ -- (see all 15)	--	41(a) 38(a) (see all 15)	many ↔ many many ↔ many (see all 15)	16(40458-41204) Un(62829135-62830402)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 25)	--	46(a) 46(a) (see all 25)	many ↔ many many ↔ many (see all 25)	AAWZ02040156(3915-5955) AAWZ02038573(7605-9645)
zebrafish (Danio rerio)	Actinopterygii	si:ch211-287j19.6⁶ CABZ01089980.1⁶ (see all 7)	--	26(a) 25(a) (see all 7)	many ↔ many many ↔ many (see all 7)	1(47613228-47619236) 3(502131-512626)

ENSEMBL Gene Tree for HLA-G (if available)
TreeFam Gene Tree for HLA-G (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HLA-G gene

HLA-F² MR1² HFE² HLA-B² FCGRT² HLA-E² HLA-C² HLA-A²

18/114 SIMAP similar genes for HLA-G using alignment to 96 protein entries: HLAG_HUMAN (see all proteins) (see all similar genes):

HLA G locus MHC-G HLA-G3 HLA-ABC HLA-A*0201V3 HLA-Cw3

HLA-A24AK HLA-A*24 Cw*08 HLAC MHC HLA-A*33

DKFZp686P19218 HLA-A*2410 Cw*03 HLA-B*4202 HLA-Cw*07 HLA-Cw*0707

HLA-G for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1233336^1,2	F,	--	29596236(-)	`ccaggT/Ggtggt`	1	--	us2k¹		2		WA NA	238
rs9461563^1,2		--	29596800(+)	`gaaacC/Tgcatt`	1	--	us2k¹		0	--	--	--	--
rs1233335^1,2	F,	--	29596921(-)	`TTGTTG/CTTTAT`	1	--	us2k¹ tfbs³		2		WA NA	238
rs1632949^1,2	C,F,A,H,	--	29597064(-)	`ttaaaA/Gagaaa`	1	--	us2k¹		22		NS EA NA WA CSA	2332
rs1736937^1,2	C,F,A,H,	--	29597216(-)	`TTAGAG/TACAGA`	1	--	us2k¹ tfbs³		11		NA WA CSA EA	374
rs56128294^1,2	C	--	29597507(+)	`TGCTCA/GAGTGC`	1	--	us2k¹		0	--	--	--	--
rs113076482^1,2		--	29597585(+)	`CACTCT/GGACTC`	1	--	us2k¹		2		CSA WA	120
rs112835540^1,2	C,	--	29597652(+)	`TAGAGC/TCACAG`	1	--	us2k¹		1		NA	2
rs17875392^1,2	F	--	29598417(+)	`GGGGG-/GAAAAA`	1	--	int¹ trp³		1		MN	66
rs112940953^1,2		--	29598423(+)	`GGGGAG/AAAAAA`	1	--	int¹		1		CSA	2

HapMap Linkage Disequilibrium report for HLA-G (29794744 - 29798902 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for HLA-G
3 CNVs: 64462 64460 3599
Human Gene Mutation Database (HGMD): HLA-G

Locus Specific Mutation Databases (LSDB): HLA-G

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-G

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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HLA-G for disorders           About GeneDecksing

OMIM gene information: 142871
OMIM disorders: 600807
20/127 diseases for HLA-G (see all 127):    About MalaCards

severe pre-eclampsia monoclonal gammopathy of undetermined significance pre-eclampsia relapsing-remitting multiple sclerosis

soft tissue sarcoma pemphigus vulgaris patent ductus arteriosus indolent b cell lymphoma

graft versus host disease b-cell lymphomas lipid metabolism disorder placental abruption

intrahepatic cholestasis ectopic pregnancy non-hodgkin lymphoma cervical intraepithelial neoplasia

intrahepatic cholestasis of pregnancy inflammatory bowel disease bladder transitional cell carcinoma polycythemia vera

2 diseases from the University of Copenhagen DISEASES database for HLA-G:

pre-eclampsia Choriocarcinoma

10/89 Novoseek disease relationships for HLA-G gene (see all 89) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
choriocarcinoma	75.1	39	16202295 (5), 17949227 (2), 19145204 (2), 15209386 (2) (see all 23)
miscarriage	67.1	46	20228379 (3), 9333005 (3), 16426245 (2), 12392506 (2) (see all 24)
tumor escape	66.5	10	15814900 (2), 12552087 (1), 16911982 (1), 17072500 (1) (see all 8)
miscarriage recurrent	65.4	16	16514201 (4), 11925408 (2), 18480096 (2), 10102087 (2) (see all 9)
preeclampsia	63.7	91	14985477 (6), 12797524 (5), 7547760 (4), 11766889 (4) (see all 35)
pregnancy disorder	54.1	3	16867913 (1), 17026466 (1)
pediatric soft tissue sarcoma	49.2	3	19693535 (2), 20033427 (1)
pregnancy loss	44.3	8	17629722 (1), 19127811 (1), 12900514 (1), 19527228 (1)
lymphocytic leukemia chronic b-cell	43.2	9	18241213 (2), 19298722 (2), 18499249 (1), 15466928 (1) (see all 6)
severe pre-eclampsia	40.3	4	19811467 (2), 10611266 (1), 20070604 (1)

Genetic Association Database (GAD): HLA-G
Human Genome Epidemiology (HuGE) Navigator: HLA-G (2822 documents)

Export disorders for HLA-G gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HLA-G gene, integrated from 9 sources (see all 814):
(articles sorted by number of sources associating them with HLA-G)

Utopia: connect your pdf to the dynamic
world of online information

HLA-G and IL-10 in serum in relation to HLA-G genotype and polymorphisms. (PubMed id 15133645)^{1, 4, 9} Hviid T.V....Baricordi O.R. (2004)
HLA-G polymorphisms in couples with recurrent spontaneous abortions. (PubMed id 12392506)^{1, 4, 9} Hviid T.V....Christiansen O.B. (2002)
Disulfide bond-mediated dimerization of HLA-G on the cell surface. (PubMed id 12454284)^{1, 2, 9} Boyson J.E.... Strominger J.L. (2002)
Association of soluble HLA-G plasma levels with HLA-G alleles. (PubMed id 11169254)^{1, 4, 9} Rebmann V....Grosse-Wilde H. (2001)
Altered HLA-G transcription in pre-eclampsia is associated with allele specific inheritance: possible role of the HLA-G gene in susceptibility to the disease. (PubMed id 11766889)^{1, 4, 9} O'Brien M....Moreau P. (2001)
HLA-G and HLA-E polymorphisms in an indigenous African population. The ZVITAMBO Study Group. (PubMed id 11137220)^{1, 4, 9} Matte C....Roger M. (2000)
Genetic variants in nonclassical major histocompatibility complex class I human leukocyte antigen (HLA)-E and HLA-G molecules are associated with susceptibility to heterosexual acquisition of HIV-1. (PubMed id 16362895)^{1, 4, 9} Lajoie J....Roger M. (2006)
Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer. (PubMed id 16455647)^{1, 2, 9} Shiroishi M.... Maenaka K. (2006)
Association between human leukocyte antigen-G genotype and success of in vitro fertilization and pregnancy outcome. (PubMed id 15191524)^{1, 4, 9} Hviid T.V....Christiansen O.B. (2004)
Analysis of human leukocyte antigen (HLA)-G polymorphism in normal women and in women with recurrent spontaneous abortions. (PubMed id 15548266)^{1, 4, 9} Abbas A....Agrawal S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3135	HGNC: 4964	AceView: HLA-G	Ensembl:ENSG00000204632	euGenes: HUgn3135
ECgene: HLA-G	Kegg: 3135	H-InvDB: HLA-G

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HLA-G	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HLA-G gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HLA-G gene:
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GeneCards and IP:
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HLA-G Gene

major histocompatibility complex, class I, G

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HLA-G Gene

major histocompatibility complex, class I, G

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