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Aliases for HLA-G Gene

Aliases for HLA-G Gene

  • Major Histocompatibility Complex, Class I, G 2 3
  • HLA-G Histocompatibility Antigen, Class I, G 2 3
  • MHC Class I Antigen G 3 4
  • B2 Microglobulin 2 3
  • HLA G Antigen 3 4
  • HLA Class I Histocompatibility Antigen, Alpha Chain G 3
  • HLA Class I Molecule 3
  • HLA-6.0 4
  • MHC-G 3
  • HLAG 4

External Ids for HLA-G Gene

Previous GeneCards Identifiers for HLA-G Gene

  • GC06P029852
  • GC06P029565
  • GC06P029904
  • GC06P029906
  • GC06P029907
  • GC06P029913
  • GC06P029598
  • GC06P029794

Summaries for HLA-G Gene

Entrez Gene Summary for HLA-G Gene

  • HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-G Gene

HLA-G (Major Histocompatibility Complex, Class I, G) is a Protein Coding gene. Diseases associated with HLA-G include severe pre-eclampsia and vaginal cancer. Among its related pathways are Class I MHC mediated antigen processing and presentation and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include protein homodimerization activity and peptide antigen binding. An important paralog of this gene is MR1.

UniProtKB/Swiss-Prot for HLA-G Gene

  • Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells

Gene Wiki entry for HLA-G Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-G Gene

Genomics for HLA-G Gene

Regulatory Elements for HLA-G Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HLA-G Gene

Start:
29,826,967 bp from pter
End:
29,831,125 bp from pter
Size:
4,159 bases
Orientation:
Plus strand

Genomic View for HLA-G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HLA-G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-G Gene

  • Protein details for HLA-G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17693-HLAG_HUMAN
    Recommended name:
    HLA class I histocompatibility antigen, alpha chain G
    Protein Accession:
    P17693
    Secondary Accessions:

    Protein attributes for HLA-G Gene

    Size:
    338 amino acids
    Molecular mass:
    38224 Da
    Quaternary structure:
    • Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Homodimer; disulfide-linked. Binds to LILRB1 and LILRB2.

    Three dimensional structures from OCA and Proteopedia for HLA-G Gene

neXtProt entry for HLA-G Gene

Proteomics data for HLA-G Gene at MOPED

Post-translational modifications for HLA-G Gene

Other Protein References for HLA-G Gene

No data available for DME Specific Peptides for HLA-G Gene

Domains for HLA-G Gene

Gene Families for HLA-G Gene

HGNC:
  • C1SET :Immunoglobulin superfamily / C1-set domain containing
  • HLA :Histocompatibility complex

Graphical View of Domain Structure for InterPro Entry

P17693

UniProtKB/Swiss-Prot:

HLAG_HUMAN :
  • P17693
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with HLA-G: view

Function for HLA-G Gene

Molecular function for HLA-G Gene

GENATLAS Biochemistry: HLA class Ib ,6.0kb Hind III fragment,expressed in trophoblast (see MHC1),including a 5 locus control region (see LCR- HLA-G)
UniProtKB/Swiss-Prot Function: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells

Gene Ontology (GO) - Molecular Function for HLA-G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20702625
GO:0005515 protein binding --
GO:0042605 peptide antigen binding IBA --
GO:0042803 protein homodimerization activity NAS 18550825
genes like me logo Genes that share ontologies with HLA-G: view
genes like me logo Genes that share phenotypes with HLA-G: view

Animal Models for HLA-G Gene

MGI Knock Outs for HLA-G:

Animal Model Products

CRISPR Products

miRNA for HLA-G Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HLA-G

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HLA-G Gene

Localization for HLA-G Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-G Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HLA-G Gene COMPARTMENTS Subcellular localization image for HLA-G gene
Compartment Confidence
endoplasmic reticulum 4
endosome 4
golgi apparatus 4
plasma membrane 4
extracellular 2
nucleus 2
cytoskeleton 1
cytosol 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HLA-G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005886 plasma membrane TAS --
GO:0012507 ER to Golgi transport vesicle membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HLA-G: view

Pathways for HLA-G Gene

genes like me logo Genes that share pathways with HLA-G: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HLA-G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity IEA --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS --
GO:0002645 positive regulation of tolerance induction IMP 22802125
genes like me logo Genes that share ontologies with HLA-G: view

Compounds for HLA-G Gene

(27) Novoseek inferred chemical compound relationships for HLA-G Gene

Compound -log(P) Hits PubMed IDs
1-methyltryptophan 46.5 1
indoleamine 35 6
5-aza-2deoxycytidine 32.3 10
neopterin 12.7 4
matrigel 12.5 2

(1) PharmGKB related drug/compound annotations for HLA-G Gene

Drug/compound Annotation
methotrexate CA
genes like me logo Genes that share compounds with HLA-G: view

Transcripts for HLA-G Gene

Unigene Clusters for HLA-G Gene

Major histocompatibility complex, class I, G:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HLA-G

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-G Gene

No ASD Table

Relevant External Links for HLA-G Gene

GeneLoc Exon Structure for
HLA-G
ECgene alternative splicing isoforms for
HLA-G

Expression for HLA-G Gene

mRNA expression in normal human tissues for HLA-G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-G Gene

This gene is overexpressed in Pituitary (12.0), Whole Blood (6.7), Lung (4.2), and Testis (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HLA-G Gene

SOURCE GeneReport for Unigene cluster for HLA-G Gene Hs.512152

mRNA Expression by UniProt/SwissProt for HLA-G Gene

P17693-HLAG_HUMAN
Tissue specificity: Expressed in trophoblasts
genes like me logo Genes that share expressions with HLA-G: view

In Situ Assay Products

Orthologs for HLA-G Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for HLA-G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 68 (a)
ManyToMany
PATR-G 35
  • 98.95 (n)
  • 97.63 (a)
mouse
(Mus musculus)
Mammalia H2-M3 35
  • 71.41 (n)
  • 64.08 (a)
H2-M3 16
rat
(Rattus norvegicus)
Mammalia RT1-M3-1 35
  • 72.33 (n)
  • 63.07 (a)
Species with no ortholog for HLA-G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HLA-G Gene

ENSEMBL:
Gene Tree for HLA-G (if available)
TreeFam:
Gene Tree for HLA-G (if available)

Paralogs for HLA-G Gene

Paralogs for HLA-G Gene

genes like me logo Genes that share paralogs with HLA-G: view

Variants for HLA-G Gene

Sequence variations from dbSNP and Humsavar for HLA-G Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1707 -- 29,830,833(+) TGACT(C/T)CTCTT utr-variant-3-prime
rs1710 -- 29,830,840(+) TCTTT(C/G)TGCAG utr-variant-3-prime
rs394146 -- 29,831,458(-) GTGAG(A/G)CTCCA downstream-variant-500B
rs421550 -- 29,831,449(-) CATCT(A/C)AAAAA downstream-variant-500B
rs915667 -- 29,830,363(-) GAAAA(C/T)GTCCT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HLA-G Gene

Variant ID Type Subtype PubMed ID
esv25966 CNV Gain+Loss 19812545
nsv428139 CNV Gain 18775914
dgv1039e201 CNV Deletion 23290073
nsv883532 CNV Loss 21882294
esv2731772 CNV Deletion 23290073
dgv1086e199 CNV Deletion 23128226
esv2731775 CNV Deletion 23290073
esv2670487 CNV Deletion 23128226
dgv1909e1 CNV Complex 17122850
dgv1910e1 CNV Complex 17122850
esv2665698 CNV Deletion 23128226

Relevant External Links for HLA-G Gene

HapMap Linkage Disequilibrium report
HLA-G
Human Gene Mutation Database (HGMD)
HLA-G
Locus Specific Mutation Databases (LSDB)
HLA-G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-G Gene

Disorders for HLA-G Gene

MalaCards: The human disease database

MalaCards: The human disease database. (13) Diseases for HLA-G Gene including...

Search for HLA-G Gene in MalaCards »

(1) OMIM Diseases for HLA-G Gene (142871)

(2) University of Copenhagen DISEASES for HLA-G Gene

(89) Novoseek inferred disease relationships for HLA-G Gene

Disease -log(P) Hits PubMed IDs
choriocarcinoma 75.1 31
miscarriage 67.1 31
tumor escape 66.5 9
miscarriage recurrent 65.4 16
preeclampsia 63.7 72

Relevant External Links for HLA-G

Genetic Association Database (GAD)
HLA-G
Human Genome Epidemiology (HuGE) Navigator
HLA-G
genes like me logo Genes that share disorders with HLA-G: view

No data available for UniProtKB/Swiss-Prot for HLA-G Gene

Publications for HLA-G Gene

  1. Association of soluble HLA-G plasma levels with HLA-G alleles. (PMID: 11169254) Rebmann V. … Grosse-Wilde H. (Tissue Antigens 2001) 3 23 48
  2. Altered HLA-G transcription in pre-eclampsia is associated with allele specific inheritance: possible role of the HLA-G gene in susceptibility to the disease. (PMID: 11766889) O'Brien M. … Moreau P. (Cell. Mol. Life Sci. 2001) 3 23 48
  3. HLA-G polymorphisms in couples with recurrent spontaneous abortions. (PMID: 12392506) Hviid T.V. … Christiansen O.B. (Tissue Antigens 2002) 3 23 48
  4. Variation in the HLA-G promoter region influences miscarriage rates. (PMID: 12721954) Ober C. … Hyslop T. (Am. J. Hum. Genet. 2003) 3 23 48
  5. Disulfide bond-mediated dimerization of HLA-G on the cell surface. (PMID: 12454284) Boyson J.E. … Strominger J.L. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 23

Products for HLA-G Gene

Sources for HLA-G Gene

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