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HLA-G Gene

protein-coding   GIFtS: 64
GCID: GC06P029794

Major Histocompatibility Complex, Class I, G

(Previous names: HLA-G histocompatibility antigen, class I, G)
  See HLA-G-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Major Histocompatibility Complex, Class I, G1 2     MHC-G2
HLA-G Histocompatibility Antigen, Class I, G1 2     HLA Class I Histocompatibility Antigen, Alpha Chain G2
B2 Microglobulin1 2     HLA Class I Molecule2
HLA G Antigen2 3     HLA-6.03
MHC Class I Antigen G2 3     HLAG3

External Ids:    HGNC: 49641   Entrez Gene: 31352   Ensembl: ENSG000002046327   OMIM: 1428715   UniProtKB: P176933   

Export aliases for HLA-G gene to outside databases

Previous GC identifers: GC06P029852 GC06P029565 GC06P029904 GC06P029906 GC06P029907 GC06P029913 GC06P029598


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HLA-G Gene:
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a
heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is
expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8
exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind
the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the
cytoplasmic tail. (provided by RefSeq, Jul 2008)

GeneCards Summary for HLA-G Gene:
HLA-G (major histocompatibility complex, class I, G) is a protein-coding gene. Diseases associated with HLA-G include severe pre-eclampsia, and vaginal cancer. GO annotations related to this gene include peptide antigen binding and protein homodimerization activity. An important paralog of this gene is HLA-F.

UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693
Function: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal
tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic
T-lymphocytes, macrophages and mononuclear cells

Gene Wiki entry for HLA-G Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NT_167244.2  NT_167245.2  NT_167247.2  NC_018917.2  NT_113891.3  NT_167246.2  
NT_167248.2  NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HLA-G gene promoter:
         AP-1   RREB-1   ATF-2   p300   IRF-1   AP-2gamma   CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLA-G promoter sequence
   Search Chromatin IP Primers for HLA-G

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.3

HLA-G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-G gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P029794:  view genomic region     (about GC identifiers)

Start:
29,794,744 bp from pter      End:
29,798,902 bp from pter
Size:
4,159 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,NT_167247 1,095,035-1,099,178      Chr6+,NT_167246 1,095,086-1,099,228      Chr6+,NT_167249 1,132,308-1,136,465     
Chr6+,NT_167245 1,095,377-1,099,520      Chr6+,NT_167248 1,095,341-1,099,498      Chr6+,NT_113891.2 1,310,647-1,314,804     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693 (See protein sequence)
Recommended Name: HLA class I histocompatibility antigen, alpha chain G precursor  
Size: 338 amino acids; 38224 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Homodimer; disulfide-linked. Binds
to LILRB1 and LILRB2
Selected PDB 3D structures from and Proteopedia for HLA-G (see all 8):
1YDP (3D)        2D31 (3D)        2DYP (3D)        3BZE (3D)        3CDG (3D)        3CII (3D)    

Explore the universe of human proteins at neXtProt for HLA-G: NX_P17693

Explore proteomics data for HLA-G at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys267
  • Glycosylation2 at Asn110
  • Modification sites at PhosphoSitePlus

  • See HLA-G Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002118.1  
    ENSEMBL proteins: 
     ENSP00000366024   ENSP00000353472   ENSP00000366014   ENSP00000436375   ENSP00000366011  
     ENSP00000412927  
    Reactome Protein details: P17693

    HLA-G Human Recombinant Protein Products:

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    Novus Biologicals HLA-G Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HLA-G 

     
    antibodies-online proteins for HLA-G (8 products) 

     
    antibodies-online peptides for HLA-G

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    antibodies-online antibodies for HLA-G (258 products) 

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    Search eBioscience for ELISAs for HLA-G 
    antibodies-online kits for HLA-G (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HLA: Histocompatibility complex
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    Selected InterPro protein domains (see all 8):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P17693

    ProtoNet protein and cluster: P17693

    2 Blocks protein domains:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Find genes that share domains with HLA-G           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HLAG_HUMAN, P17693
    Function: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal
    tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic
    T-lymphocytes, macrophages and mononuclear cells

         Genatlas biochemistry entry for HLA-G:
    HLA class Ib ,6.0kb Hind III fragment,expressed in trophoblast (see MHC1),including a 5' locus control region (see
    LCR- HLA-G)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI--
    GO:0005515protein binding ----
    GO:0042605peptide antigen binding IBA--
    GO:0042803protein homodimerization activity NAS18550825
         
    Find genes that share ontologies with HLA-G           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for HLA-G:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for H2-M3):
     hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with HLA-G           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out H2-M3H2-tm1Crw for HLA-G

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HLA-G
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HLA-G

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HLA-G
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HLA-G

    miRNA
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    miRTarBase miRNAs that target HLA-G:
    hsa-mir-152-3p (MIRT000293), hsa-mir-148b-3p (MIRT000295), hsa-mir-148a-3p (MIRT000297)

    Block miRNA regulation of human, mouse, rat HLA-G using miScript Target Protectors
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10079) for HLA-G 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HLAG_HUMAN, P17693: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    endosome4
    golgi apparatus4
    plasma membrane4
    extracellular2
    nucleus2
    cytoskeleton1
    cytosol1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0012507ER to Golgi transport vesicle membrane TAS--
    GO:0016020membrane ----
    GO:0030670phagocytic vesicle membrane TAS--

    Find genes that share ontologies with HLA-G           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HLA-G About   (see all 16)  
    See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Allograft rejection0.86
    Autoimmune thyroid disease0.61
    Allograft Rejection0.86
    Viral myocarditis0.40
    Type I diabetes mellitus0.69
    CTL Mediated Apoptosis0.38
    Graft-versus-host disease0.65
    Antigen processing and presentation0.36
    2CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway0.80
    Proteasome Degradation0.57
    Antigen processing-Cross presentation0.80
    Endosomal/Vacuolar pathway0.00
    3Immune response Role of DAP12 receptors in NK cells
    Immune response Role of DAP12 receptors in NK cells0.33
    Natural killer cell mediated cytotoxicity0.31
    4Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    5Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41


    Find genes that share SuperPaths with HLA-G           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HLA-G
        CDC42 Pathway
    CTL Mediated Apoptosis

    1 GeneGo (Thomson Reuters) Pathway for HLA-G
        Immune response Role of DAP12 receptors in NK cells

    2 BioSystems Pathways for HLA-G
        Allograft Rejection
    Proteasome Degradation

    Selected Reactome Pathways for HLA-G (see all 6)
        Endosomal/Vacuolar pathway
    Interferon alpha/beta signaling
    Interferon gamma signaling
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    Selected Kegg Pathways  (Kegg details for HLA-G) (see all 14):
        Endocytosis
    Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Natural killer cell mediated cytotoxicity

        Pathway & Disease-focused RT2 Profiler PCR Array including HLA-G: 
              Type I Interferon Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HLA-G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HLA-G (P176932, 3 ENSP000003534724) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LILRB1Q8NHL62, 3, ENSP000003159974MINT-7144982 I2D: score=3 STRING: ENSP00000315997
    ENSG00000206235Q035193I2D: score=3 
    ENSG00000206299Q035193I2D: score=3 
    ENSG00000223481Q035193I2D: score=3 
    ENSG00000225967Q035193I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001916positive regulation of T cell mediated cytotoxicity IEA--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0002480antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS--
    GO:0002666positive regulation of T cell tolerance induction IMP--

    Find genes that share ontologies with HLA-G           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HLA-G (HLAG)

    Selected Novoseek inferred chemical compound relationships for HLA-G gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1-methyltryptophan 46.5 1 16236119 (1)
    indoleamine 35 6 15878889 (2), 18289708 (2), 19143868 (1), 16129951 (1)
    5-aza-2'deoxycytidine 32.3 32 16045815 (4), 18823661 (3), 18498645 (2), 12552087 (1)
    neopterin 12.7 5 2129033 (2), 2117484 (1), 1878399 (1)
    matrigel 12.5 2 10684818 (2)
    ifn-alpha 12.5 1 12183445 (1)
    progesterone 7.59 23 19527229 (4), 16210391 (4), 20052552 (2), 18824770 (2) (see all 9)
    sodium 4.47 1 12545635 (1)
    oxygen 2.05 4 18325889 (1), 16807282 (1)
    cholesterol 0.747 1 8079411 (1)

    1 PharmGKB related drug/compound annotation for HLA-G gene    About this table
    Drug/compound PharmGKB Annotation
    methotrexateCA  



    Find genes that share compounds with HLA-G           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HLA-G gene: 
    NM_002127.5  

    Unigene Cluster for HLA-G:

    Major histocompatibility complex, class I, G
    Hs.512152  [show with all ESTs]
    Unigene Representative Sequence: AK093478
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376828(uc003raj.3) ENST00000360323(uc003nnz.3 uc010jrn.2 uc011dmb.2)
    ENST00000478355 ENST00000376818 ENST00000478519(uc003nny.3) ENST00000376815(uc003ran.1)
    ENST00000428701(uc003nnw.2)
    miRNA
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    Primer
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    eBioscience FlowRNA Probe Sets ( VA1-10079) for HLA-G 

    Additional mRNA sequence: 

    AF071017.1 AF071018.1 AF071019.1 AF071020.1 AF071021.1 AF071022.1 AF196177.1 AF196178.1 
    AF226990.2 AF436089.1 AK093478.1 AK302054.1 AY359818.1 BC021708.2 M32800.1 M90683.1 
    M90684.1 M90685.1 M90686.1 U58024.1 U58025.1 U58026.1 U58027.1 U58028.1 
    U58029.1 U58094.1 U88244.1 X17273.1 

    16 DOTS entries:

    DT.100753459  DT.100825997  DT.455506  DT.95158992  DT.100645441  DT.100753462  DT.100809966  DT.100733427 
    DT.100733440  DT.100855576  DT.100733391  DT.100859573  DT.121345649  DT.315161  DT.91722926  DT.91783937 

    Selected AceView cDNA sequences (see all 25):

    CR613246 CR608458 CR606159 AF196177 M90684 AF071018 X17273 M90686 
    AF226990 AF071021 CR623340 AF196178 AF071020 M90683 M90685 AF071022 
    AK093478 BC021708 M32800 U88244 AF071019 AY359818 NM_002127 AX748153 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HLA-G expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HLA-G Expression
    About this image


    HLA-G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)
             Mesenchymal Stem Cells Wharton's Jelly
     
     Bone (Muscoskeletal System)
             Bone marrow-derived adherent progenitor cells (MultiStem)
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Wharton's Jelly
     
     Amnion (Extraembryonic Tissues)
             Amniotic Epithelial Cells Amniotic Membrane
     
     Placenta (Extraembryonic Tissues)
             Syncytiotrophoblast-like cells
    HLA-G Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HLA-G Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512152

    UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693
    Tissue specificity: Expressed in trophoblasts

        Pathway & Disease-focused RT2 Profiler PCR Array including HLA-G: 
              Type I Interferon Response in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for HLA-G gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia H2-M31 , 5 histocompatibility 2, M region locus 31, 5 71.41(n)1
    64.08(a)1
      17 (19.16 cM)5
    149911  NM_013819.21  NP_038847.11 
     372702205 


    ENSEMBL Gene Tree for HLA-G (if available)
    TreeFam Gene Tree for HLA-G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HLA-G gene
    HLA-F2  MR12  FCGRT2  HFE2  HLA-B2  HLA-E2  HLA-C2  HLA-A2  
    AZGP12  
    Selected SIMAP similar genes for HLA-G using alignment to 101 protein entries:     HLAG_HUMAN (see all proteins) (see all similar genes):
    HLA G locus    MHC-G    HLA-G3    HLA-ABC    HLA-A*0201V3    HLA-Cw3
    HLA-A24AK    HLA-A*24    Cw*08    HLAC    MHC    HLA-A*33
    DKFZp686P19218    HLA-A*2410    Cw*03    HLA-B*4202    HLA-Cw*07    HLA-Cw*0707

    Find genes that share paralogs with HLA-G           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HLA-G (see all 276)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1397811251,2
    --29596143(+) GGTTTC/TACCAT 1 -- us2k10--------
    rs12333361,2
    C,F--29596236(-) ccaggT/Ggtggt 1 -- us2k12Minor allele frequency- G:0.05WA NA 238
    rs1454765181,2
    --29596276(+) TAACTC/TAGTTT 1 -- us2k10--------
    rs16329511,2
    C,F,A,H--29596298(-) TGGAAC/ATTCTC 1 -- us2k114Minor allele frequency- A:0.47NA WA CSA EA 515
    rs16329501,2
    C,F,A--29596336(-) TCATTA/GTGAAT 1 -- us2k112Minor allele frequency- G:0.46MN NA WA CSA 570
    rs17369421,2
    C,F,A--29596361(-) GGAAAC/TTGAAG 1 -- us2k1 tfbs34Minor allele frequency- T:0.50NA WA CSA 8
    rs1858423041,2
    --29596445(+) CAGCTC/TCTGGT 1 -- us2k10--------
    rs1901643891,2
    --29596500(+) TGCTGC/TGAAGG 1 -- us2k10--------
    rs1504269371,2
    C--29596502(+) CTGTGA/GAGGGA 1 -- us2k10--------
    rs1142516531,2
    C,F--29596564(+) TCCTGC/TTTGGA 1 -- us2k13Minor allele frequency- T:0.06WA NA EA 358

    HapMap Linkage Disequilibrium report for HLA-G (29794744 - 29798902 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HLA-G (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665698CNV Deletion23128226
    dgv1086e199CNV Deletion23128226
    esv2731775CNV Deletion23290073
    esv2731772CNV Deletion23290073
    esv2670487CNV Deletion23128226
    dgv1039e201CNV Deletion23290073
    nsv883532CNV Loss21882294
    nsv428139CNV Gain18775914
    esv25966CNV Gain+Loss19812545
    dgv1910e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): HLA-G
    Locus Specific Mutation Databases (LSDB): HLA-G

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142871   
    OMIM disorders: 600807  
    12 diseases for HLA-G:    
    About MalaCards
    severe pre-eclampsia    vaginal cancer    intrahepatic cholestasis of pregnancy    soft tissue sarcoma
    rabies    leukopenia    placental abruption    eclampsia
    pemphigus vulgaris    pre-eclampsia    pregnancy loss    asthma

    2 diseases from the University of Copenhagen DISEASES database for HLA-G:
    pre-eclampsia     Cancer

    Find genes that share disorders with HLA-G           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HLA-G gene (see all 89)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 75.1 39 16202295 (5), 17949227 (2), 19145204 (2), 15209386 (2) (see all 23)
    miscarriage 67.1 46 20228379 (3), 9333005 (3), 16426245 (2), 12392506 (2) (see all 24)
    tumor escape 66.5 10 15814900 (2), 12552087 (1), 16911982 (1), 17072500 (1) (see all 8)
    miscarriage recurrent 65.4 16 16514201 (4), 11925408 (2), 18480096 (2), 10102087 (2) (see all 9)
    preeclampsia 63.7 91 14985477 (6), 12797524 (5), 7547760 (4), 11766889 (4) (see all 35)
    pregnancy disorder 54.1 3 16867913 (1), 17026466 (1)
    pediatric soft tissue sarcoma 49.2 3 19693535 (2), 20033427 (1)
    pregnancy loss 44.3 8 17629722 (1), 19127811 (1), 12900514 (1), 19527228 (1)
    lymphocytic leukemia chronic b-cell 43.2 9 18241213 (2), 19298722 (2), 18499249 (1), 15466928 (1) (see all 6)
    severe pre-eclampsia 40.3 4 19811467 (2), 10611266 (1), 20070604 (1)

    Genetic Association Database (GAD): HLA-G
    Human Genome Epidemiology (HuGE) Navigator: HLA-G (2822 documents)

    Export disorders for HLA-G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HLA-G gene, integrated from 10 sources (see all 871):
    (articles sorted by number of sources associating them with HLA-G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HLA-G polymorphisms and HLA-G expression in sarcoidosis. (PubMed id 16933468)1, 4, 9 Hviid T.V....Larsen L.G. (Sarcoidosis Vasc Diffuse Lung Dis 2006)
    2. HLA-G and IL-10 in serum in relation to HLA-G genotype and polymorphisms. (PubMed id 15133645)1, 4, 9 Hviid T.V....Baricordi O.R. (Immunogenetics 2004)
    3. HLA-G genotype and HLA-G expression in systemic lupus erythematosus: HLA-G as a putative susceptibility gene in systemic lupus erythematosus. (PubMed id 18380776)1, 4, 9 Rizzo R....Baricordi O.R. (Tissue Antigens 2008)
    4. HLA-G polymorphisms in couples with recurrent spontaneous abortions. (PubMed id 12392506)1, 4, 9 Hviid T.V....Christiansen O.B. (Tissue Antigens 2002)
    5. The genetic structure of 3'untranslated region of the HLA-G gene: polymorphisms and haplotypes. (PubMed id 19798077)1, 4, 9 Castelli E.C....Donadi E.A. (Genes Immun. 2010)
    6. A study of HLA-G polymorphism and linkage disequilibrium in renal transplant patients and their donors. (PubMed id 18926911)1, 4, 9 Pirri A....Bicalho M.d.a. .G. (Transpl. Immunol. 2009)
    7. The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease. (PubMed id 17446213)1, 4, 9 Glas J....Weiss E.H. (Int. Immunol. 2007)
    8. HLA-G polymorphism in a Chinese Han population with recurrent spontaneous abortion. (PubMed id 16426245)1, 4, 9 Yan W.H....Yao F.J. (Int. J. Immunogenet. 2006)
    9. HLA-G DNA sequence variants and risk of perinatal HIV-1 transmission. (PubMed id 17059603)1, 4, 9 Aikhionbare F.O....Bond V.C. (AIDS Res Ther 2006)
    10. Disulfide bond-mediated dimerization of HLA-G on the cell surface. (PubMed id 12454284)1, 2, 9 Boyson J.E.... Strominger J.L. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3135 HGNC: 4964 AceView: HLA-G Ensembl:ENSG00000204632 euGenes: HUgn3135
    ECgene: HLA-G Kegg: 3135 H-InvDB: HLA-G

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HLA-G Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HLA-G Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HLA-G gene:
    Search GeneIP for patents involving HLA-G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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