Aliases for HLA-G Gene
External Ids for HLA-G Gene
Previous GeneCards Identifiers for HLA-G Gene
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
GeneCards Summary for HLA-G Gene
HLA-G (Major Histocompatibility Complex, Class I, G) is a Protein Coding gene. Diseases associated with HLA-G include severe pre-eclampsia and vaginal cancer. Among its related pathways are Class I MHC mediated antigen processing and presentation and Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include protein homodimerization activity and peptide antigen binding. An important paralog of this gene is MR1.
UniProtKB/Swiss-Prot for HLA-G Gene
Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells