Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLA-G Gene

protein-coding   GIFtS: 65
GCID: GC06P029794

Major Histocompatibility Complex, Class I, G

(Previous names: HLA-G histocompatibility antigen, class I, G)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Major Histocompatibility Complex, Class I, G1 2     MHC-G2
HLA-G Histocompatibility Antigen, Class I, G1 2     HLA Class I Histocompatibility Antigen, Alpha Chain G2
B2 Microglobulin1 2     HLA Class I Molecule2
HLA G Antigen2 3     HLA-6.03
MHC Class I Antigen G2 3     HLAG3

External Ids:    HGNC: 49641   Entrez Gene: 31352   Ensembl: ENSG000002046327   OMIM: 1428715   UniProtKB: P176933   

Export aliases for HLA-G gene to outside databases

Previous GC identifers: GC06P029852 GC06P029565 GC06P029904 GC06P029906 GC06P029907 GC06P029913 GC06P029598


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HLA-G Gene:
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a
heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is
expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8
exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind
the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the
cytoplasmic tail. (provided by RefSeq, Jul 2008)

GeneCards Summary for HLA-G Gene: 
HLA-G (major histocompatibility complex, class I, G) is a protein-coding gene. Diseases associated with HLA-G include severe pre-eclampsia, and indolent b cell lymphoma, and among its related super-pathways are Allograft rejection and ER-Phagosome pathway. GO annotations related to this gene include MHC class I receptor activity and protein homodimerization activity. An important paralog of this gene is HLA-F.

UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693
Function: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal
tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic
T-lymphocytes, macrophages and mononuclear cells

Gene Wiki entry for HLA-G Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  NT_167249.1  
NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLA-G gene promoter:
         AP-1   RREB-1   ATF-2   p300   IRF-1   AP-2gamma   CREB   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLA-G promoter sequence
   Search SABiosciences Chromatin IP Primers for HLA-G

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-G


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.3

HLA-G Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-G gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P029794:  view genomic region     (about GC identifiers)

Start:
29,794,744 bp from pter      End:
29,798,902 bp from pter
Size:
4,159 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,NT_167249 1,132,308-1,136,465      Chr6+,NT_167248 1,095,341-1,099,498      Chr6+,NT_167246 1,095,086-1,099,228     
Chr6+,NT_167245 1,095,377-1,099,520      Chr6+,NT_167247 1,095,035-1,099,178      Chr6+,NT_113891.2 1,310,647-1,314,804     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693 (See protein sequence)
Recommended Name: HLA class I histocompatibility antigen, alpha chain G precursor  
Size: 338 amino acids; 38224 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Homodimer; disulfide-linked. Binds
to LILRB1 and LILRB2
Subcellular location: Membrane; Single-pass type I membrane protein
6/8 PDB 3D structures from and Proteopedia for HLA-G (see all 8):
1YDP (3D)        2D31 (3D)        2DYP (3D)        3BZE (3D)        3CDG (3D)        3CII (3D)    

Explore the universe of human proteins at neXtProt for HLA-G: NX_P17693

Explore proteomics data for HLA-G at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17693

  • HLA-G Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HLA-G Protein Expression
    REFSEQ proteins: NP_002118.1  
    ENSEMBL proteins: 
     ENSP00000366024   ENSP00000353472   ENSP00000366014   ENSP00000436375   ENSP00000366011  
     ENSP00000412927  
    Reactome Protein details: P17693
    Human Recombinant Protein Products for HLA-G: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HLA-G
    OriGene Protein Over-expression Lysate for HLA-G
    OriGene MassSpec for HLA-G 
    OriGene Custom Protein Services for HLA-G
    GenScript Custom Purified and Recombinant Proteins Services for HLA-G
    Novus Biologicals HLA-G Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0012507ER to Golgi transport vesicle membrane TAS--
    GO:0030670phagocytic vesicle membrane TAS--
    GO:0031901early endosome membrane TAS--

    HLA-G for ontologies           About GeneDecksing



    HLA-G Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HLA-G
    GenScript Custom Superior Antibodies Services for HLA-G
    Novus Biologicals HLA-G Antibodies
    Abcam antibodies for HLA-G
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for HLA-G
    LSBio Antibodies in human, mouse, rat for HLA-G 

    Assay Products for HLA-G: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HLA-G
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HLA-G
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HLA: Histocompatibility complex
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    5/7 InterPro protein domains (see all 7):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P17693

    ProtoNet protein and cluster: P17693

    2 Blocks protein domains:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    HLA-G for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HLAG_HUMAN, P17693
    Function: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal
    tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic
    T-lymphocytes, macrophages and mononuclear cells

         Genatlas biochemistry entry for HLA-G:
    HLA class Ib ,6.0kb Hind III fragment,expressed in trophoblast (see MHC1),including a 5' locus control region (see
    LCR- HLA-G)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IPI--
    GO:0005515protein binding ----
    GO:0042605peptide antigen binding IBA--
    GO:0042803protein homodimerization activity NAS18550825
         
    HLA-G for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HLA-G:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for H2-M3):
     hematopoietic system  homeostasis/metabolism  immune system 

    HLA-G for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out H2-M3H2-tm1Crw for HLA-G

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HLA-G 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HLA-G

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HLA-G 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HLA-G 

    miRNA
    Products:
        
    miRTarBase miRNAs that target HLA-G:
    hsa-mir-152 (MIRT000293), hsa-mir-148b (MIRT000295), hsa-mir-148a (MIRT000297)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-G
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HLA-G
    SwitchGear 3'UTR luciferase reporter plasmidHLA-G 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HLA-G
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-G

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HLA-G
    Sirion Biotech Customized adenovirus for overexpression of HLA-G

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HLA-G (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLA-G (NM_002127)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-G
    Sirion Biotech Customized lentivirus for stable overexpression of HLA-G 
                         Customized lentivirus expression plasmids for stable overexpression of HLA-G 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HLA-G
    Search LifeMap BioReagents cell lines for HLA-G
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-G


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HLA-G About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Allograft rejection0.69
    Antigen processing and presentation0.37
    Type I diabetes mellitus0.69
    CTL Mediated Apoptosis0.36
    Graft-versus-host disease0.65
    Viral myocarditis0.35
    Autoimmune thyroid disease0.62
    2CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway0.81
    Proteasome Degradation0.57
    Antigen processing-Cross presentation0.81
    3Immune response Fc epsilon RI pathway
    Immune response Role of DAP12 receptors in NK cells0.32
    Natural killer cell mediated cytotoxicity0.31
    4Interferon Signaling
    Interferon Signaling0.61
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.61
    5Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for HLA-G
        Immune response Role of DAP12 receptors in NK cells

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HLA-G
        CDC42 Pathway
    CTL Mediated Apoptosis

    1 GeneGo (Thomson Reuters) Pathway for HLA-G
        Immune response Role of DAP12 receptors in NK cells

    1 BioSystems Pathway for HLA-G
        Proteasome Degradation

    5/12        Reactome Pathways for HLA-G (see all 12)
        Endosomal/Vacuolar pathway
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Interferon alpha/beta signaling
    Interferon gamma signaling
    Cytokine Signaling in Immune system


    5/14         Kegg Pathways  (Kegg details for HLA-G) (see all 14):
        Endocytosis
    Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Natural killer cell mediated cytotoxicity


    HLA-G for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLA-G

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/68 Interacting proteins for HLA-G (P176932, 3 ENSP000003534724) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LILRB1Q8NHL62, 3, ENSP000003159974MINT-7144982 I2D: score=3 STRING: ENSP00000315997
    ENSG00000206235Q035193I2D: score=3 
    ENSG00000206299Q035193I2D: score=3 
    ENSG00000223481Q035193I2D: score=3 
    ENSG00000225967Q035193I2D: score=3 
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001916positive regulation of T cell mediated cytotoxicity IEA--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0002480antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS--
    GO:0002666positive regulation of T cell tolerance induction IMP--

    HLA-G for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HLA-G for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HLA-G (HLAG)

    10/27 Novoseek inferred chemical compound relationships for HLA-G gene (see all 27)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    1-methyltryptophan 46.5 1 16236119 (1)
    indoleamine 35 6 15878889 (2), 18289708 (2), 19143868 (1), 16129951 (1)
    5-aza-2'deoxycytidine 32.3 32 16045815 (4), 18823661 (3), 18498645 (2), 12552087 (1)
    neopterin 12.7 5 2129033 (2), 2117484 (1), 1878399 (1)
    matrigel 12.5 2 10684818 (2)
    ifn-alpha 12.5 1 12183445 (1)
    progesterone 7.59 23 19527229 (4), 16210391 (4), 20052552 (2), 18824770 (2) (see all 9)
    sodium 4.47 1 12545635 (1)
    oxygen 2.05 4 18325889 (1), 16807282 (1)
    cholesterol 0.747 1 8079411 (1)

    1 PharmGKB related drug/compound annotation for HLA-G gene    About this table
    Drug/compound PharmGKB Annotation
    methotrexateCA  

    Search CenterWatch for drugs/clinical trials and news about HLA-G / HLAG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HLA-G gene: 
    NM_002127.5  

    Unigene Cluster for HLA-G:

    Major histocompatibility complex, class I, G
    Hs.512152  [show with all ESTs]
    Unigene Representative Sequence: AK093478
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376828(uc003raj.3) ENST00000360323(uc003nnz.3 uc010jrn.2 uc011dmb.2)
    ENST00000478355 ENST00000376818 ENST00000478519(uc003nny.3) ENST00000376815(uc003ran.1)
    ENST00000428701(uc003nnw.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-G
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HLA-G
    SwitchGear 3'UTR luciferase reporter plasmidHLA-G 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HLA-G
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-G
    Clone
    Products:
         
    OriGene clones in human, mouse for HLA-G (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLA-G (NM_002127)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-G
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-G
    Sirion Biotech Customized lentivirus for stable overexpression of HLA-G 
                         Customized lentivirus expression plasmids for stable overexpression of HLA-G 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HLA-G
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-G
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HLA-G
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-G
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-G

    Additional mRNA sequence: 

    AF071017.1 AF071018.1 AF071019.1 AF071020.1 AF071021.1 AF071022.1 AF196177.1 AF196178.1 
    AF226990.2 AF436089.1 AK093478.1 AK302054.1 AY359818.1 BC021708.2 M32800.1 M90683.1 
    M90684.1 M90685.1 M90686.1 U58024.1 U58025.1 U58026.1 U58027.1 U58028.1 
    U58029.1 U58094.1 U88244.1 X17273.1 

    16 DOTS entries:

    DT.100753459  DT.100825997  DT.455506  DT.95158992  DT.100645441  DT.100753462  DT.100809966  DT.100733427 
    DT.100733440  DT.100855576  DT.100733391  DT.100859573  DT.121345649  DT.315161  DT.91722926  DT.91783937 

    24/25 AceView cDNA sequences (see all 25):

    CR608458 CR613246 CR623340 AF071020 AF226990 AF071021 M90684 AF196177 
    AF071018 CR606159 M90686 AF196178 X17273 M90683 AF071022 AK093478 
    U88244 AF071019 M90685 BC021708 M32800 NM_002127 AF071017 AY359818 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HLA-G expression in normal human tissues (normalized intensities)      HLA-G embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HLA-G Expression
    About this image


    HLA-G expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             visceral organ/lung/right lung   
     
     Melanocytes (Integumentary System)
             Human EpiDermal Melanocytes-dark (HEM-dark)   
     
     Epidermis (Integumentary System)
             Human EpiDermal Melanocytes-dark (HEM-dark)   
     
     Umbilical Cord (Extraembryonic Tissues)
             Mesenchymal Stem Cells Wharton's Jelly
     
     Bone (Muscoskeletal System)
             Bone marrow-derived adherent progenitor cells (MultiStem)

    See HLA-G Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HLA-G

    SOURCE GeneReport for Unigene cluster: Hs.512152

    UniProtKB/Swiss-Prot: HLAG_HUMAN, P17693
    Tissue specificity: Expressed in trophoblasts

        SABiosciences Expression via Pathway-Focused PCR Array including HLA-G: 
              Type I Interferon Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HLA-G
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-G
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HLA-G
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-G
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-G
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-G

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for HLA-G gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia H2-M31 , 5 histocompatibility 2, M region locus 31, 5 71.5(n)1
    63.72(a)1
      17 (19.16 cM)5
    149911  NM_013819.21  NP_038847.11 
     372702205 


    ENSEMBL Gene Tree for HLA-G (if available)
    TreeFam Gene Tree for HLA-G (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HLA-G gene
    HLA-F2  MR12  FCGRT2  HFE2  HLA-B2  HLA-E2  HLA-C2  HLA-A2  
    18/114 SIMAP similar genes for HLA-G using alignment to 97 protein entries:     HLAG_HUMAN (see all proteins) (see all similar genes):
    HLA G locus    MHC-G    HLA-G3    HLA-ABC    HLA-A*0201V3    HLA-Cw3
    HLA-A24AK    HLA-A*24    Cw*08    HLAC    MHC    HLA-A*33
    DKFZp686P19218    HLA-A*2410    Cw*03    HLA-B*4202    HLA-Cw*07    HLA-Cw*0707

    HLA-G for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/276 SNPs in HLA-G are shown (see all 276)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1397811251,2
    --29596143(+) GGTTTC/TACCAT 1 -- us2k10--------
    rs12333361,2
    C,F--29596236(-) ccaggT/Ggtggt 1 -- us2k12Minor allele frequency- G:0.05WA NA 238
    rs1454765181,2
    --29596276(+) TAACTC/TAGTTT 1 -- us2k10--------
    rs16329511,2
    C,F,A,H--29596298(-) TGGAAC/ATTCTC 1 -- us2k114Minor allele frequency- A:0.47NA WA CSA EA 515
    rs16329501,2
    C,F,A--29596336(-) TCATTA/GTGAAT 1 -- us2k112Minor allele frequency- G:0.46MN NA WA CSA 570
    rs17369421,2
    C,F,A--29596361(-) GGAAAC/TTGAAG 1 -- us2k1 tfbs34Minor allele frequency- T:0.50NA WA CSA 8
    rs1858423041,2
    --29596445(+) CAGCTC/TCTGGT 1 -- us2k10--------
    rs1901643891,2
    --29596500(+) TGCTGC/TGAAGG 1 -- us2k10--------
    rs1504269371,2
    C--29596502(+) CTGTGA/GAGGGA 1 -- us2k10--------
    rs1142516531,2
    C,F--29596564(+) TCCTGC/TTTGGA 1 -- us2k13Minor allele frequency- T:0.06WA NA EA 358

    HapMap Linkage Disequilibrium report for HLA-G (29794744 - 29798902 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for HLA-G (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2665698CNV Deletion23128226
    dgv1086e199CNV Deletion23128226
    esv2731775CNV Deletion23290073
    esv2731772CNV Deletion23290073
    esv2670487CNV Deletion23128226
    dgv1039e201CNV Deletion23290073
    nsv883532CNV Loss21882294
    nsv428139CNV Gain18775914
    esv25966CNV Gain+Loss19812545
    dgv1910e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): HLA-G

    Locus Specific Mutation Databases (LSDB): HLA-G
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HLA-G
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-G

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142871   
    OMIM disorders: 600807  
    20/124 diseases for HLA-G (see all 124):    About MalaCards
    severe pre-eclampsia    indolent b cell lymphoma    lipid metabolism disorder    soft tissue sarcoma
    eclampsia    rabies    pre-eclampsia    intrahepatic cholestasis of pregnancy
    pemphigus vulgaris    leukopenia    intrahepatic cholestasis    pemphigus
    cholestasis    placental abruption    ectopic pregnancy    bladder transitional cell carcinoma
    choriocarcinoma    transitional cell carcinoma    adenomyosis    relapsing-remitting multiple sclerosis

    2 diseases from the University of Copenhagen DISEASES database for HLA-G:
    pre-eclampsia     Cancer

    HLA-G for disorders           About GeneDecksing

    10/89 Novoseek inferred disease relationships for HLA-G gene (see all 89)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 75.1 39 16202295 (5), 17949227 (2), 19145204 (2), 15209386 (2) (see all 23)
    miscarriage 67.1 46 20228379 (3), 9333005 (3), 16426245 (2), 12392506 (2) (see all 24)
    tumor escape 66.5 10 15814900 (2), 12552087 (1), 16911982 (1), 17072500 (1) (see all 8)
    miscarriage recurrent 65.4 16 16514201 (4), 11925408 (2), 18480096 (2), 10102087 (2) (see all 9)
    preeclampsia 63.7 91 14985477 (6), 12797524 (5), 7547760 (4), 11766889 (4) (see all 35)
    pregnancy disorder 54.1 3 16867913 (1), 17026466 (1)
    pediatric soft tissue sarcoma 49.2 3 19693535 (2), 20033427 (1)
    pregnancy loss 44.3 8 17629722 (1), 19127811 (1), 12900514 (1), 19527228 (1)
    lymphocytic leukemia chronic b-cell 43.2 9 18241213 (2), 19298722 (2), 18499249 (1), 15466928 (1) (see all 6)
    severe pre-eclampsia 40.3 4 19811467 (2), 10611266 (1), 20070604 (1)

    Genetic Association Database (GAD): HLA-G
    Human Genome Epidemiology (HuGE) Navigator: HLA-G (2822 documents)

    Export disorders for HLA-G gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HLA-G gene, integrated from 9 sources (see all 855):
    (articles sorted by number of sources associating them with HLA-G)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HLA-G polymorphisms and HLA-G expression in sarcoidosis. (PubMed id 16933468)1, 4, 9 Hviid T.V....Larsen L.G. (2006)
    2. HLA-G and IL-10 in serum in relation to HLA-G genotype and polymorphisms. (PubMed id 15133645)1, 4, 9 Hviid T.V....Baricordi O.R. (2004)
    3. HLA-G genotype and HLA-G expression in systemic lupus erythematosus: HLA-G as a putative susceptibility gene in systemic lupus erythematosus. (PubMed id 18380776)1, 4, 9 Rizzo R....Baricordi O.R. (2008)
    4. HLA-G polymorphisms in couples with recurrent spontaneous abortions. (PubMed id 12392506)1, 4, 9 Hviid T.V....Christiansen O.B. (2002)
    5. The genetic structure of 3'untranslated region of the HLA-G gene: polymorphisms and haplotypes. (PubMed id 19798077)1, 4, 9 Castelli E.C....Donadi E.A. (2010)
    6. A study of HLA-G polymorphism and linkage disequilibrium in renal transplant patients and their donors. (PubMed id 18926911)1, 4, 9 Pirri A....Bicalho M.d.a. .G. (2009)
    7. The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease. (PubMed id 17446213)1, 4, 9 Glas J....Weiss E.H. (2007)
    8. HLA-G polymorphism in a Chinese Han population with recurrent spontaneous abortion. (PubMed id 16426245)1, 4, 9 Yan W.H....Yao F.J. (2006)
    9. HLA-G DNA sequence variants and risk of perinatal HIV-1 transmission. (PubMed id 17059603)1, 4, 9 Aikhionbare F.O....Bond V.C. (2006)
    10. Disulfide bond-mediated dimerization of HLA-G on the cell surface. (PubMed id 12454284)1, 2, 9 Boyson J.E.... Strominger J.L. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3135 HGNC: 4964 AceView: HLA-G Ensembl:ENSG00000204632 euGenes: HUgn3135
    ECgene: HLA-G Kegg: 3135 H-InvDB: HLA-G

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HLA-G Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HLA-G Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HLA-G gene:
    Search GeneIP for patents involving HLA-G

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HLA-G  
     OriGene qPCR primer pairs and template standards for HLA-G   OriGene Protein Over-expression Lysate for HLA-G  
     OriGene MassSpec something-or-other for HLA-G   OriGene clones in human, mouse for HLA-G  
     OriGene qSTAR qPCR primer pairs in human, mouse for HLA-G   OriGene Purified Protein for HLA-G  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HLA-G   OriGene Custom Protein Services for HLA-G  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HLA-G
     QIAGEN SeqTarget long-range PCR primers for resequencing HLA-G
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-G
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-G
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-G
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-G
     GenScript Custom Purified and Recombinant Proteins Services for HLA-G GenScript cDNA clones with any tag delivered in your preferred vector for HLA-G
     GenScript Custom Assay Services for HLA-G GenScript Custom Superior Antibodies Services for HLA-G
     GenScript Custom overexpressing Cell Line Services for HLA-G CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HLA-G promoter
     Search Chromatin IP Primers for HLA-G
     RT2 qPCR Primer Assay in human, mouse, rat HLA-G
     GNC Network for HLA-G
     SABiosciences PCR Arrays including human, mouse, rat HLA-G
     Search Tocris compounds for HLA-G (HLAG)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HLA-G antibodies
     HLA-G lysates
     Antibodies for HLA-G
     See all of Abcam's Antibodies, Kits and Proteins for HLA-G
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for HLA-G
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-G
     SwitchGear 3'UTR luciferase reporter plasmids for HLA-G
     SwitchGear Promoter luciferase reporter plasmids for HLA-G
     ThermoFisher Antibody for HLA-G
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-G
     inGenious Targeting Laboratory - Custom generated mouse model solutions for HLA-G
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HLA-G
    Customized:
     lentivirus for stable overexpression of HLA-G
     lentivirus expression plasmids for stable overexpression of HLA-G
     adenovirus for overexpression of HLA-G
     LSBio Antibodies in human, mouse, rat for HLA-G
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HLA-G gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4