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Aliases for HLA-G Gene

Aliases for HLA-G Gene

  • Major Histocompatibility Complex, Class I, G 2 3 5
  • HLA-G Histocompatibility Antigen, Class I, G 2 3
  • MHC Class I Antigen G 3 4
  • B2 Microglobulin 2 3
  • HLA G Antigen 3 4
  • HLA Class I Molecule 3
  • HLA-6.0 4
  • MHC-G 3
  • HLAG 4

External Ids for HLA-G Gene

Previous GeneCards Identifiers for HLA-G Gene

  • GC06P029852
  • GC06P029565
  • GC06P029904
  • GC06P029906
  • GC06P029907
  • GC06P029913
  • GC06P029598
  • GC06P029794
  • GC06P030042
  • GC06P030088

Summaries for HLA-G Gene

Entrez Gene Summary for HLA-G Gene

  • HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-G Gene

HLA-G (Major Histocompatibility Complex, Class I, G) is a Protein Coding gene. Diseases associated with HLA-G include Severe Pre-Eclampsia and Vaginal Cancer. Among its related pathways are HTLV-I infection and Natural Killer Cell Receptors: Human Target Cell ?�� NK Cell Ligand-Receptor Interactions. GO annotations related to this gene include protein homodimerization activity and peptide antigen binding. An important paralog of this gene is HLA-B.

UniProtKB/Swiss-Prot for HLA-G Gene

  • Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.

Gene Wiki entry for HLA-G Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-G Gene

Genomics for HLA-G Gene

Regulatory Elements for HLA-G Gene

Enhancers for HLA-G Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HLA-G on UCSC Golden Path with GeneCards custom track

Genomic Location for HLA-G Gene

Chromosome:
6
Start:
29,826,967 bp from pter
End:
29,831,125 bp from pter
Size:
4,159 bases
Orientation:
Plus strand

Genomic View for HLA-G Gene

Genes around HLA-G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-G Gene

  • Protein details for HLA-G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17693-HLAG_HUMAN
    Recommended name:
    HLA class I histocompatibility antigen, alpha chain G
    Protein Accession:
    P17693

    Protein attributes for HLA-G Gene

    Size:
    338 amino acids
    Molecular mass:
    38224 Da
    Quaternary structure:
    • Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Homodimer; disulfide-linked. Binds to LILRB1 and LILRB2.

    Three dimensional structures from OCA and Proteopedia for HLA-G Gene

neXtProt entry for HLA-G Gene

Proteomics data for HLA-G Gene at MOPED

Post-translational modifications for HLA-G Gene

  • Glycosylation at Asn 110
  • Modification sites at PhosphoSitePlus

Other Protein References for HLA-G Gene

No data available for DME Specific Peptides for HLA-G Gene

Domains & Families for HLA-G Gene

Graphical View of Domain Structure for InterPro Entry

P17693

UniProtKB/Swiss-Prot:

HLAG_HUMAN :
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Belongs to the MHC class I family.
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with HLA-G: view

Function for HLA-G Gene

Molecular function for HLA-G Gene

GENATLAS Biochemistry:
HLA class Ib ,6.0kb Hind III fragment,expressed in trophoblast (see MHC1),including a 5 locus control region (see LCR- HLA-G)
UniProtKB/Swiss-Prot Function:
Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells.

Gene Ontology (GO) - Molecular Function for HLA-G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 20702625
genes like me logo Genes that share ontologies with HLA-G: view
genes like me logo Genes that share phenotypes with HLA-G: view

Animal Models for HLA-G Gene

MGI Knock Outs for HLA-G:

Animal Model Products

CRISPR Products

miRNA for HLA-G Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HLA-G Gene

Localization for HLA-G Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-G Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HLA-G Gene COMPARTMENTS Subcellular localization image for HLA-G gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
plasma membrane 5
golgi apparatus 4
extracellular 2
nucleus 2
cytosol 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HLA-G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0012507 ER to Golgi transport vesicle membrane TAS --
genes like me logo Genes that share ontologies with HLA-G: view

Pathways & Interactions for HLA-G Gene

genes like me logo Genes that share pathways with HLA-G: view

SIGNOR curated interactions for HLA-G Gene

Activates:

Gene Ontology (GO) - Biological Process for HLA-G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0019882 antigen processing and presentation IBA --
GO:0032735 positive regulation of interleukin-12 production IDA 20702625
GO:0042130 negative regulation of T cell proliferation IDA 20702625
GO:0045591 positive regulation of regulatory T cell differentiation IMP 20448110
genes like me logo Genes that share ontologies with HLA-G: view

Drugs & Compounds for HLA-G Gene

(14) Drugs for HLA-G Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR, Cytotoxic agent 1466
Capecitabine Approved, Investigational Pharma RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1239
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1697
hmg coa reductase inhibitors Pharma 0

(16) Additional Compounds for HLA-G Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HLA-G: view

Transcripts for HLA-G Gene

Unigene Clusters for HLA-G Gene

Major histocompatibility complex, class I, G:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-G Gene

No ASD Table

Relevant External Links for HLA-G Gene

GeneLoc Exon Structure for
HLA-G
ECgene alternative splicing isoforms for
HLA-G

Expression for HLA-G Gene

mRNA expression in normal human tissues for HLA-G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-G Gene

This gene is overexpressed in Pituitary (x12.0), Whole Blood (x6.7), Lung (x4.2), and Testis (x4.1).

Protein differential expression in normal tissues from HIPED for HLA-G Gene

This gene is overexpressed in Skin (29.9) and Blymphocyte (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HLA-G Gene



SOURCE GeneReport for Unigene cluster for HLA-G Gene Hs.512152

mRNA Expression by UniProt/SwissProt for HLA-G Gene

P17693-HLAG_HUMAN
Tissue specificity: Expressed in trophoblasts.
genes like me logo Genes that share expression patterns with HLA-G: view

No data available for Protein tissue co-expression partners for HLA-G Gene

Orthologs for HLA-G Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for HLA-G Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia H2-M3 35
  • 71.41 (n)
  • 64.08 (a)
H2-M3 16
chimpanzee
(Pan troglodytes)
Mammalia PATR-G 35
  • 98.95 (n)
  • 97.63 (a)
-- 36
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia RT1-M3-1 35
  • 72.33 (n)
  • 63.07 (a)
Species with no ortholog for HLA-G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HLA-G Gene

ENSEMBL:
Gene Tree for HLA-G (if available)
TreeFam:
Gene Tree for HLA-G (if available)

Paralogs for HLA-G Gene

Paralogs for HLA-G Gene

genes like me logo Genes that share paralogs with HLA-G: view

Variants for HLA-G Gene

Sequence variations from dbSNP and Humsavar for HLA-G Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1049033 -- 29,829,862(-) ACCAG(A/G)CCAGC reference, synonymous-codon
rs1063320 -- 29,830,972(-) CAGTG(C/G)ACCAC utr-variant-3-prime
rs1130355 -- 29,828,216(-) TACTC(C/G/T)GGCCC reference, synonymous-codon
rs1130356 -- 29,828,550(+) TCTCA(C/T)ACCCT intron-variant, reference, synonymous-codon
rs1130363 -- 29,829,919(+) TGGAG(A/G)AAGAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for HLA-G Gene

Variant ID Type Subtype PubMed ID
esv25966 CNV Gain+Loss 19812545
nsv428139 CNV Gain 18775914
dgv1039e201 CNV Deletion 23290073
nsv883532 CNV Loss 21882294
esv2731772 CNV Deletion 23290073
dgv1086e199 CNV Deletion 23128226
esv2731775 CNV Deletion 23290073
esv2670487 CNV Deletion 23128226
dgv1909e1 CNV Complex 17122850
dgv1910e1 CNV Complex 17122850
esv2665698 CNV Deletion 23128226

Variation tolerance for HLA-G Gene

Residual Variation Intolerance Score: 81.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.44; 81.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HLA-G Gene

Human Gene Mutation Database (HGMD)
HLA-G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-G Gene

Disorders for HLA-G Gene

MalaCards: The human disease database

(28) MalaCards diseases for HLA-G Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
severe pre-eclampsia
  • antepartum severe pre-eclampsia
vaginal cancer
  • malignant neoplasm of vagina
choriocarcinoma
  • choriocarcinoma, no icd-o subtype
asthma
  • asthma, protection against
thymic dysplasia
- elite association - COSMIC cancer census association via MalaCards
Search HLA-G in MalaCards View complete list of genes associated with diseases

Relevant External Links for HLA-G

Genetic Association Database (GAD)
HLA-G
Human Genome Epidemiology (HuGE) Navigator
HLA-G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HLA-G
genes like me logo Genes that share disorders with HLA-G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HLA-G Gene

Publications for HLA-G Gene

  1. HLA-G polymorphisms and HLA-G expression in sarcoidosis. (PMID: 16933468) Hviid T.V. … Larsen L.G. (Sarcoidosis Vasc Diffuse Lung Dis 2006) 3 23 48 67
  2. The genetic structure of 3'untranslated region of the HLA-G gene: polymorphisms and haplotypes. (PMID: 19798077) Castelli E.C. … Donadi E.A. (Genes Immun. 2010) 3 23
  3. ILT2/HLA-G interaction impairs NK-cell functions through the inhibition of the late but not the early events of the NK-cell activating synapse. (PMID: 19841038) Favier B. … Carosella E.D. (FASEB J. 2010) 3 23
  4. HLA-G expression in human breast cancer: implications for diagnosis and prognosis, and effect on allocytotoxic lymphocyte response after hormone treatment in vitro. (PMID: 20052552) He X. … Chen J. (Ann. Surg. Oncol. 2010) 3 23
  5. HLA-G and its relation to proliferation index in detection and monitoring breast cancer patients. (PMID: 20196818) Sayed D. … Alhazza I.M. (Tissue Antigens 2010) 3 23

Products for HLA-G Gene

Sources for HLA-G Gene

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