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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLA-F-AS1 Gene

RNA gene   GIFtS: 23
GCID: GC06M029729

HLA-F antisense RNA 1

(Previous name: HLA-F antisense RNA 1 (non-protein coding) )
 Explore 2 diseases affiliated with
HLA-F-AS1 via our new
 Human Malady Compendium 
Biological research products
for HLA-F-AS1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Subcategory (RNA class): processed_transcript

Quality score for this RNA gene is 3

Aliases
HLA-F Antisense RNA 11 2
HLA-F Antisense RNA 1 (Non-Protein Coding)1

External Ids:    HGNC: 266451   Entrez Gene: 2858302   Ensembl: ENSG000002149227   

Export aliases for HLA-F-AS1 gene to outside databases

Previous GC identifers: GC06M029717 GC06M029721 GC06M029724


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167248.1  NT_167249.1  
NT_167247.1  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for HLA-F-AS1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-F-AS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HLA-F-AS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-F-AS1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M029729:  view genomic region     (about GC identifiers)

Start:
29,694,378 bp from pter      End:
29,716,826 bp from pter
Size:
22,449 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,ALT_REF_LOCI_4 29,614,544-29,636,993      Chr6-,ALT_REF_LOCI_5 29,624,567-29,628,783      Chr6-,ALT_REF_LOCI_3 29,691,865-29,725,345     
Chr6-,ALT_REF_LOCI_6 29,691,842-29,749,873      Chr6-,ALT_REF_LOCI_2 29,688,359-29,749,985      Chr6-,ALT_REF_LOCI_7 29,621,593-29,644,041     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
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UniProtKB: --


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
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Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HLA-F-AS1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
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Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HLA-F-AS1
Search CenterWatch for drugs/clinical trials and news about HLA-F-AS1 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HLA-F-AS1 gene: 
NM_001003807.1  

Unigene Cluster for HLA-F-AS1:

HLA-F antisense RNA 1
Hs.646985  [show with all ESTs]
Unigene Representative Sequence: AL832418
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000399247(uc003nnp.2 uc011dlz.1) ENST00000458236(uc003rsi.3)
ENST00000434086

miRNA
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Inhib. RNA
Products:
     
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Clone
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-F-AS1
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Additional cDNA sequence: 

AK092748.1 AL832418.1 NR_026972.1 NR_026973.1 

9 DOTS entries:

DT.455506  DT.91815219  DT.100020854  DT.421607  DT.100825996  DT.121345897  DT.40309926  DT.75169653 
DT.95147001 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for HLA-F-AS1:none

HLA-F-AS1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTATCATCAA

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
Genevestigator expression for HLA-F-AS1

SOURCE GeneReport for Unigene cluster: Hs.646985
    SABiosciences Custom PCR Arrays for HLA-F-AS1
Primer
Products:
OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-F-AS1
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-F-AS1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for HLA-F-AS1 (if available)
TreeFam Gene Tree for HLA-F-AS1 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/323 NCBI SNPs in HLA-F-AS1 are shown (see all 323    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1422956951,2
--29697066(+) CACCAA/GAAGCC 2 -- int10--------
rs1138428911,2
--29697130(+) TTTATC/TAGTGC 2 -- int11Minor allele frequency- T:0.50CSA 2
rs92958101,2
C,F,H,--29697240(+) catcaC/Gcttac 2 -- int15Minor allele frequency- G:0.03NS EA WA 536
rs1165880411,2
--29697377(+) CTTCTT/CGGCTG 2 -- int11Minor allele frequency- C:0.01NA 120
rs623918191,2
C,F,--29697420(+) AATAAA/GTTAGA 2 -- int12Minor allele frequency- G:0.07NA EA 240
rs16331071,2
C,F,H,--29697473(-) actctC/Gttaat 2 -- int110Minor allele frequency- G:0.27NA WA CSA EA 371
rs1150516941,2
--29697508(+) GGAAAT/CATTTG 2 -- int11Minor allele frequency- C:0.01NA 120
rs17369191,2
C,F,A,H,--29697517(-) tataaC/Ttggca 2 -- int123Minor allele frequency- T:0.31NS EA NA WA CSA 1307
rs1917065421,2
--29697525(+) ATATAC/TCTGAT 2 -- int10--------
rs1459369071,2
--29697664(+) GCACAG/TGAAAA 2 -- int10--------

HapMap Linkage Disequilibrium report for HLA-F-AS1 (29694378 - 29716826 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for HLA-F-AS1: --

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HLA-F-AS1 for disorders           About GeneDecksing

2 diseases for HLA-F-AS1:    About MalaCards
systemic lupus erythematosus    lupus erythematosus


Export disorders for HLA-F-AS1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for HLA-F-AS1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HLA-F-AS1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1 Barcellos L.F....Criswell L.A. (2009)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 285830 HGNC: 26645 Ensembl:ENSG00000214922 euGenes: HUgn285830 ECgene: HLA-F-AS1
H-InvDB: HLA-F-AS1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for HLA-F-AS1 gene:
Search GeneIP for patents involving HLA-F-AS1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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