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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLA-F Gene

protein-coding   GIFtS: 59
GCID: GC06P029690

major histocompatibility complex, class I, F
 Explore 19 diseases affiliated with
HLA-F via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HLA-F    

Aliases
for HLA-F gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Major Histocompatibility Complex, Class I, F1 2     MHC Class I Antigen F2 3
HLAF2 3 5     HLA-CDA122 5
Leukocyte Antigen F2 3     HLA Class I Histocompatibility Antigen, Alpha Chain F2
CDA122 3     HLA Class I Molecule2
HLA-5.42 3     MHC Class Ib Antigen2
HLA F Antigen2 3     

External Ids:    HGNC: 49631   Entrez Gene: 31342   Ensembl: ENSG000002046427   OMIM: 1431105   UniProtKB: P305113   

Export aliases for HLA-F gene to outside databases

Previous GC identifers: GC06P029748 GC06P029461 GC06P029800 GC06P029801 GC06P029802 GC06P029499


Summaries
for HLA-F gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HLA-F:
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a
heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other
HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount
present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind
a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript
variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in
transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic
domain. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HLAF_HUMAN, P30511
Function: Involved in the presentation of foreign antigens to the immune system

Gene Wiki entry for HLA-F


Genomic Views
for HLA-F gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLA-F gene promoter:
         ISGF-3   AML1a   SREBP-1c   Bach2   p300   Ik-3   SREBP-1b   GATA-2   HOXA5   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HLA-F promoter sequence
   Search SABiosciences Chromatin IP Primers for HLA-F

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.3

HLA-F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-F gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P029690:  view genomic region     (about GC identifiers)

Start:
 29,690,552 bp from pter      End:
 29,706,305 bp from pter
Size:
 15,754 bases      Orientation:
 plus strand

6 alternative locations:
Chr6+,ALT_REF_LOCI_2 29,684,537-29,728,242      Chr6+,ALT_REF_LOCI_4 29,611,281-29,615,239      Chr6+,ALT_REF_LOCI_6 29,688,014-29,728,118     
Chr6+,ALT_REF_LOCI_5 29,603,074-29,605,304      Chr6+,ALT_REF_LOCI_3 29,688,037-29,703,789      Chr6+,ALT_REF_LOCI_7 29,618,362-29,622,288     

Proteins
for HLA-F gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HLAF_HUMAN, P30511 (See protein sequence)
Recommended Name: HLA class I histocompatibility antigen, alpha chain F precursor  
Size: 346 amino acids; 39062 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin)
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAC24827.1; Type=Erroneous gene model prediction; Sequence=AAH09260.2; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=BAB63337.1; Type=Erroneous gene model prediction;
Sequence=CAA34947.1; Type=Erroneous gene model prediction; Sequence=CAB46623.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5JQI8 Q5JQJ1 Q5SPT5 Q860R0 Q8MGQ1 Q8WLP5 Q95HC0 Q9TP68
Alternative splicing: 3 isoforms:  P30511-1   P30511-2   P30511-3   (Ref.10 (AAH09260) sequence is in conflict in position: 353:N->L)

Explore the universe of human proteins at neXtProt for HLA-F: NX_P30511

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P30511

    • HLA-F Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001091948.1  NP_001091949.1  NP_061823.2  

    ENSEMBL proteins: 
     ENSP00000366057   ENSP00000389590   ENSP00000259951   ENSP00000397376   ENSP00000416998  
     ENSP00000392251   ENSP00000334263   ENSP00000404130  
    Reactome Protein details: P30511
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HLA-F

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0012507ER to Golgi transport vesicle membrane TAS--
    GO:0030670phagocytic vesicle membrane TAS--
    GO:0031901early endosome membrane TAS--


    HLA-F for ontologies           About GeneDecksing



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    Novus Biologicals HLA-F Antibodies
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    Assay Products for HLA-F: 
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    Uscn ELISAs and CLIAs for HLA-F

    Protein Domains /
    Families
    for HLA-F gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HLA-F for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P30511

    ProtoNet protein and cluster: P30511

    3 Blocks protein families:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type
    IPB010579 MHC_I


    UniProtKB/Swiss-Prot: HLAF_HUMAN, P30511
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Function
    for HLA-F gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HLAF_HUMAN, P30511
    Function: Involved in the presentation of foreign antigens to the immune system

         Genatlas biochemistry entry for HLA-F:
    HLA class Ib,44kDa,5.4kb HindIII fragment,TAP and tapasin dependent,expression at the cell surface,correlating with the
    binding of an MHC class I leader peptide (see MHC1)

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-F

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032393MHC class I receptor activity TAS1688605


    HLA-F for ontologies           About GeneDecksing



    Pathways & Interactions
    for HLA-F gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Translocation of peptide bound MHC class I complex to cell surface
    		Translocation of peptide bound MHC class I complex to cell surface1.00
    		Endosomal/Vacuolar pathway0.78
    		Journey of cargo through Golgi complex1.00
    		Peptide loading on MHC class I in phagosome0.70
    		Expression of peptide bound class I MHC on cell surface1.00
    		Antigen Presentation: Folding, assembly and peptide loading of class I MHC0.28
    		Export of peptide loaded MHC class I complex to PM1.00
    2Allograft rejection
    		Allograft rejection1.00
    		CTL Mediated Apoptosis0.38
    		Type I diabetes mellitus0.67
    		Viral myocarditis0.33
    		Graft-versus-host disease0.63
    		Antigen processing and presentation0.25
    		Autoimmune thyroid disease0.60
    3Ubiquitinated Orc1 is degraded by the proteasome
    		ER-Phagosome pathway0.74
    		Proteasome Degradation0.56
    		Antigen processing-Cross presentation0.60
    4Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    5Immune System
    		Immune System1.00
    		Adaptive Immune System0.59

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HLA-F
        CDC42 Pathway
    CTL Mediated Apoptosis

    1 BioSystems Pathway for HLA-F 
        Proteasome Degradation

    5/19        Reactome Pathways for HLA-F (see all 19)
        Endosomal/Vacuolar pathway
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Interferon alpha/beta signaling
    Expression of IFN-induced genes
    ER-Phagosome pathway


    5/9         Kegg Pathways  (Kegg details for HLA-F) (see all 9):
        Endocytosis
    Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Type I diabetes mellitus


    HLA-F for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLA-F

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for HLA-F (P305113 ENSP000002599514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B2MP617693, ENSP000003408584I2D: score=2 STRING: ENSP00000340858
    TAP1Q035183, ENSP000003462064I2D: score=2 STRING: ENSP00000346206
    LILRB1Q8NHL63, ENSP000003159974I2D: score=2 STRING: ENSP00000315997
    LILRB2Q8N4233, ENSP000003756294I2D: score=2 STRING: ENSP00000375629
    --ENSP000003977054STRING: ENSP00000397705
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0002480antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS--
    GO:0006955immune response ----
    GO:0019221cytokine-mediated signaling pathway TAS--


    HLA-F for ontologies           About GeneDecksing



    Drugs & Compounds
    for HLA-F gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HLA-F
    Search CenterWatch for drugs/clinical trials and news about HLA-F / HLAF 

    Transcripts
    for HLA-F gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HLA-F gene (3 alternative transcripts): 
    NM_001098478.1  NM_001098479.1  NM_018950.2  

    Unigene Cluster for HLA-F:

    Major histocompatibility complex, class I, F
    Hs.519972  [show with all ESTs]
    Unigene Representative Sequence: AK096962
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376861(uc010jrl.3 uc003nnm.4) ENST00000414333 ENST00000462777
    ENST00000259951(uc003nno.4) ENST00000489502 ENST00000482257 ENST00000434407
    ENST00000486194 ENST00000485513 ENST00000429294 ENST00000484704 ENST00000465459
    ENST00000475996(uc011dlx.1) ENST00000444621 ENST00000334668 ENST00000440587(uc011dly.1)


    miRNA
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK096962.1 AK125274.1 AK225185.1 AK298704.1 AK300090.1 AK301488.1 AK302420.1 AK303670.1 
    AK309156.1 AY216682.1 AY221102.1 AY253269.1 AY253270.1 AY253271.1 BC009260.2 BC062991.1 
    DQ367723.1 GQ891552.1 

    24/40 DOTS entries (see all 40):

    DT.121346401  DT.121346314  DT.100856917  DT.455506  DT.108834  DT.121346207  DT.100825996  DT.100042764 
    DT.315161  DT.121345652  DT.121346277  DT.40309926  DT.91783982  DT.92453534  DT.100825994  DT.95306295 
    DT.100036944  DT.100859573  DT.121346130  DT.95376339  DT.100733427  DT.121346112  DT.95376642  DT.121346040 

    23 AceView cDNA sequences:

    AY253270 NM_018950 AY253271 BC062991 AK125274 AA988615 AY253269 AK096962 
    BQ016533 AY216682 AY221102 BC009260 BF477881 AW610235 AW993267 BE328079 
    BF110304 BE765149 CD629526 AA847453 BE764966 BF807762 AW820588 

    GeneLoc Exon Structure


    Expression
    for HLA-F gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HLA-F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCAGCACGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HLA-F Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HLA-F

    SOURCE GeneReport for Unigene cluster: Hs.519972
        SABiosciences Custom PCR Arrays for HLA-F
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-F

    Orthologs
    for HLA-F gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-F gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NM79_CHICK6
    --
    (see all 15)    		 --
    		 42(a)
    38(a)
    (see all 15)    		 many ↔ many
    many ↔ many
    (see all 15)    		 16(40458-41204)
    16(25465-26697)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 25)    		 --
    		 46(a)
    46(a)
    (see all 25)    		 many ↔ many
    many ↔ many
    (see all 25)    		 AAWZ02039289(783-2823)
    AAWZ02038573(7605-9645)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch211-287j19.66
    CABZ01089980.16
    (see all 7)    		 --
    		 25(a)
    25(a)
    (see all 7)    		 many ↔ many
    many ↔ many
    (see all 7)    		 1(47613228-47619236)
    3(502131-512626)


    ENSEMBL Gene Tree for HLA-F (if available)
    TreeFam Gene Tree for HLA-F (if available) 

    Paralogs
    for HLA-F gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HLA-F gene
    MR12  HFE2  HLA-B2  FCGRT2  HLA-E2  HLA-C2  HLA-A2  HLA-G2  
    18/115 SIMAP similar genes for HLA-F using alignment to 44 protein entries:     HLAF_HUMAN (see all proteins) (see all similar genes):
    HLA-A*0201V3    HLA-ABC    HLA-Cw3    HLA C*    HLA-A24AK    HLA-B41
    HLA-B27    B-1510    HLA G locus    HLA-B*27    HLA-A*33    HLA-B*3512
    Cw    HLA-A*01    HLA-B*1513    B-3501    HLA-A*02    HLA-A*0226

    HLA-F for paralogs           About GeneDecksing


    5/65 Pseudogenes.org Pseudogenes for HLA-F (see all 65)
    PGOHUM00000238621 PGOHUM00000238662 PGOHUM00000238789 PGOHUM00000238906 PGOHUM00000242166


    Genomic Variants
    for HLA-F gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/224 NCBI SNPs in HLA-F are shown (see all 224)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs709839931,2
    		C--29497997(+) GTAAA-/TGTG  
                TGTGT     		1 -- int11Minor allele frequency- TGTG:0.00NA 2
    rs37573241,2
    		C,F,A,H,--29689127(+) GATGCG/TATTAA 3 -- us2k1 tfbs326Minor allele frequency- T:0.22NS EA MN NA WA CSA 3116
    rs16329561,2
    		C,F,A,H,--29689164(-) TGTTGA/TCTAGT 3 -- us2k1 tfbs316Minor allele frequency- T:0.13NS EA NA MN WA CSA 849
    rs37573251,2
    		C,F,A,H,--29689202(+) CAGGTA/TTGCCC 3 -- us2k117Minor allele frequency- T:0.20NS EA MN NA WA 1560
    rs37573261,2
    		C,F,A,--29689249(+) CAAGAC/GCGAAG 3 -- us2k18Minor allele frequency- G:0.20MN NA WA EA 548
    rs69251431,2
    		C,F,--29689254(+) CCGAAG/CTGGAG 3 -- us2k16Minor allele frequency- C:0.10MN WA NA CSA 300
    rs1908214991,2
    		--29689412(+) AGGGCA/CTGAGG 3 -- us2k10--------
    rs1440017831,2
    		--29689423(+) GATGAA/GAGGGA 3 -- us2k10--------
    rs1464445441,2
    		--29689513(+) TTAAAC/TACATT 3 -- us2k10--------
    rs92581691,2
    		C,F,A,H,--29689532(+) AATTTT/GTAATA 3 -- us2k17Minor allele frequency- G:0.18NS EA WA NA 648

    HapMap Linkage Disequilibrium report for HLA-F (29690552 - 29706305 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for HLA-F
         2 CNVs: 64462 64460
    Locus Specific Mutation Databases (LSDB): HLA-F

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-F
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-F

    Disorders / Diseases
    for HLA-F gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HLA-F for disorders           About GeneDecksing

    OMIM gene information: 143110    OMIM disorders: --

    19 diseases for HLA-F:    About MalaCards
    graft versus host disease    corneal dystrophy    systemic lupus erythematosus    lupus erythematosus
    multiple sclerosis    kaposi's sarcoma    autoimmune thyroiditis    diabetes mellitus
    hemochromatosis    hepatitis b    vaccinia    sarcoma
    thyroiditis    hepatitis    tuberculosis    immunodeficiency
    carcinoma    mycobacterium tuberculosis    hiv type 1

    1 disease from the University of Copenhagen DISEASES database for HLA-F:
    Hemochromatosis
    Human Genome Epidemiology (HuGE) Navigator: HLA-F (2815 documents)

    Export disorders for HLA-F gene to outside databases

    Publications
    for HLA-F gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HLA-F gene, integrated from 9 sources (see all 123):
    (articles sorted by number of sources associating them with HLA-F)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human leukocyte antigen F (HLA-F). An expressed HLA gene composed of a class I coding sequence linked to a novel transcribed repetitive element. (PubMed id 1688605)1, 2, 3, 9 Geraghty D.E.... Koller B.H. (1990)
    2. HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the nonclassical class I genes. (PubMed id 16570139)1, 2, 9 Pyo C.W.... Geraghty D.E. (2006)
    3. Identification of a novel HLA-F allele - HLA-F*010102. (PubMed id 14705989)1, 2 He X.... Zeng Y. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. A 356-Kb sequence of the subtelomeric part of the MHC class I region. (PubMed id 10727083)1, 2 Hampe A.... Galibert F. (1999)
    6. The human class I MHC gene HLA-F is expressed in lymphocytes. (PubMed id 1707659)1, 2 Lury D.... Holmes N. (1990)
    7. HLA-F surface expression on B cell and monocyte cell lines is partially independent from tapasin and completely independent from TAP. (PubMed id 14607927)1, 9 Lee N. and Geraghty D.E. (2003)
    8. Genetic associations of common deletion polymorphisms in families with Avellino corneal dystrophy. (PubMed id 19622345)1, 9 Park M....Kim H.L. (2009)
    9. SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. (PubMed id 17971048)1, 9 Burfoot R.K....Rubio J.P. (2008)
    10. MHC-F DNA sequences in bonobo, gorilla and orangutan. (PubMed id 16185322)1, 9 Rojo R....Arnaiz-Villena A. (2005)

    External Searches for HLA-F gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing HLA-F gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3134 HGNC: 4963 AceView: HLA-F Ensembl:ENSG00000204642 euGenes: HUgn3134
    ECgene: HLA-F Kegg: 3134 H-InvDB: HLA-F

    Other Databases showing HLA-F gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HLA-F gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HLA-F Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HLA-F gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HLA-F gene:
    Search GeneIP for patents involving HLA-F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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