Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HLA-F Gene

protein-coding   GIFtS: 60
GCID: GC06P029690

Major Histocompatibility Complex, Class I, F

  Search for HLA-F
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Major Histocompatibility Complex, Class I, F1 2     MHC Class I Antigen F2 3
HLAF2 3 5     HLA-CDA122 5
Leukocyte Antigen F2 3     HLA Class I Histocompatibility Antigen, Alpha Chain F2
CDA122 3     HLA Class I Molecule2
HLA-5.42 3     MHC Class Ib Antigen2
HLA F Antigen2 3     

External Ids:    HGNC: 49631   Entrez Gene: 31342   Ensembl: ENSG000002046427   OMIM: 1431105   UniProtKB: P305113   

Export aliases for HLA-F gene to outside databases

Previous GC identifers: GC06P029748 GC06P029461 GC06P029800 GC06P029801 GC06P029802 GC06P029499


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HLA-F Gene:
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a
heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most
other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small
amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is
thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms.
Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a
coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a
shorter cytoplasmic domain. (provided by RefSeq, Jul 2008)

GeneCards Summary for HLA-F Gene:
HLA-F (major histocompatibility complex, class I, F) is a protein-coding gene. GO annotations related to this gene include peptide antigen binding and receptor binding. An important paralog of this gene is MR1.

UniProtKB/Swiss-Prot: HLAF_HUMAN, P30511
Function: Involved in the presentation of foreign antigens to the immune system

Gene Wiki entry for HLA-F Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167248.2  NT_167249.2  NC_018917.2  
NT_167247.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HLA-F gene promoter:
         ISGF-3   AML1a   SREBP-1c   Bach2   p300   Ik-3   SREBP-1b   GATA-2   HOXA5   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLA-F promoter sequence
   Search Chromatin IP Primers for HLA-F

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.3

HLA-F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-F gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P029690:  view genomic region     (about GC identifiers)

Start:
29,690,552 bp from pter      End:
29,706,305 bp from pter
Size:
15,754 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,NT_167246 991,622-995,580      Chr6+,NT_167249 1,028,897-1,032,823      Chr6+,NT_113891.2 1,207,306-1,211,258     
Chr6+,NT_167245 991,999-995,957      Chr6+,NT_167247 991,651-993,881      Chr6+,NT_167248 991,976-995,934     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HLAF_HUMAN, P30511 (See protein sequence)
Recommended Name: HLA class I histocompatibility antigen, alpha chain F precursor  
Size: 346 amino acids; 39062 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin)
Sequence caution: Sequence=AAC24827.1; Type=Erroneous gene model prediction; Sequence=AAH09260.2; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=BAB63337.1; Type=Erroneous gene model prediction;
Sequence=CAA34947.1; Type=Erroneous gene model prediction; Sequence=CAB46623.1; Type=Erroneous gene model
prediction;
Secondary accessions: Q5JQI8 Q5JQJ1 Q5SPT5 Q860R0 Q8MGQ1 Q8WLP5 Q95HC0 Q9TP68
Alternative splicing: 3 isoforms:  P30511-1   P30511-2   P30511-3   (Ref.10 (AAH09260) sequence is in conflict in position: 353:N->L)

Explore the universe of human proteins at neXtProt for HLA-F: NX_P30511

Explore proteomics data for HLA-F at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys197, Lys264
  • Glycosylation2 at Asn107
  • Modification sites at PhosphoSitePlus

  • See HLA-F Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001091948.1  NP_001091949.1  NP_061823.2  

    ENSEMBL proteins: 
     ENSP00000366057   ENSP00000389590   ENSP00000259951   ENSP00000397376   ENSP00000416998  
     ENSP00000392251   ENSP00000334263   ENSP00000404130  
    Reactome Protein details: P30511

    HLA-F Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HLA-F
    GenScript Custom Purified and Recombinant Proteins Services for HLA-F
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HLA-F 

    HLA-F Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HLA-F
    OriGene Custom Antibody Services for HLA-F
    Novus Biologicals HLA-F Antibodies
    Abcam antibodies for HLA-F
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for HLA-F
    LSBio Antibodies in human, mouse, rat for HLA-F

    HLA-F Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HLA-F
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HLA-F
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for HLA-F 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HLA: Histocompatibility complex
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    Selected InterPro protein domains (see all 8):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P30511

    ProtoNet protein and cluster: P30511

    3 Blocks protein domains:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type
    IPB010579 MHC_I


    UniProtKB/Swiss-Prot: HLAF_HUMAN, P30511
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Find genes that share domains with HLA-F           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HLAF_HUMAN, P30511
    Function: Involved in the presentation of foreign antigens to the immune system

         Genatlas biochemistry entry for HLA-F:
    HLA class Ib,44kDa,5.4kb HindIII fragment,TAP and tapasin dependent,expression at the cell surface,correlating
    with the binding of an MHC class I leader peptide (see MHC1)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IBA--
    GO:0005515protein binding ----
    GO:0042605peptide antigen binding IBA--
    GO:0046978TAP1 binding IPI10605026
    GO:0046979TAP2 binding IPI10605026
         
    Find genes that share ontologies with HLA-F           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HLA-F
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HLA-F

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HLA-F
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HLA-F

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat HLA-F using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HLA-F
    SwitchGear 3'UTR luciferase reporter plasmidHLA-F 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HLA-F
    Predesigned siRNA for gene silencing in human, mouse, rat HLA-F

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HLA-F

    Clone
    Products:
         
    OriGene clones in human, mouse for HLA-F (see all 18)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): HLA-F (NM_001098478)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-F
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-F

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HLA-F
    Browse ESI BIO Cell Lines and PureStem Progenitors for HLA-F 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-F


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HLAF_HUMAN, P30511: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    endosome4
    golgi apparatus4
    plasma membrane4
    lysosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005783endoplasmic reticulum IDA10605026
    GO:0005886plasma membrane TAS--
    GO:0012507ER to Golgi transport vesicle membrane TAS--
    GO:0030670phagocytic vesicle membrane TAS--

    Find genes that share ontologies with HLA-F           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HLA-F About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Allograft rejection0.86
    Autoimmune thyroid disease0.61
    Allograft Rejection0.86
    Viral myocarditis0.40
    Type I diabetes mellitus0.69
    CTL Mediated Apoptosis0.38
    Graft-versus-host disease0.65
    Antigen processing and presentation0.36
    2CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway0.80
    Proteasome Degradation0.57
    Antigen processing-Cross presentation0.80
    Endosomal/Vacuolar pathway0.00
    3Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    4Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    5Immune response IFN alpha beta signaling pathway
    Interferon alpha/beta signaling0.43


    Find genes that share SuperPaths with HLA-F           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HLA-F
        CDC42 Pathway
    CTL Mediated Apoptosis

    2 BioSystems Pathways for HLA-F
        Allograft Rejection
    Proteasome Degradation

    Selected Reactome Pathways for HLA-F (see all 6)
        Endosomal/Vacuolar pathway
    Interferon alpha/beta signaling
    Interferon gamma signaling
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    Selected Kegg Pathways  (Kegg details for HLA-F) (see all 13):
        Endocytosis
    Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Type I diabetes mellitus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HLA-F
    Interactions:

        GeneGlobe Interaction Network for HLA-F

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for HLA-F (P305113 ENSP000002599514) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAP1Q035183, ENSP000003462064I2D: score=2 STRING: ENSP00000346206
    ENSG00000206297Q035183I2D: score=2 
    ENSG00000224212Q035183I2D: score=2 
    ENSG00000226173Q035183I2D: score=2 
    ENSG00000227816Q035183I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001916positive regulation of T cell mediated cytotoxicity IEA--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0002480antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS--
    GO:0006955immune response ----

    Find genes that share ontologies with HLA-F           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HLA-F (HLAF)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HLA-F gene (3 alternative transcripts): 
    NM_001098478.1  NM_001098479.1  NM_018950.2  

    Unigene Cluster for HLA-F:

    Major histocompatibility complex, class I, F
    Hs.519972  [show with all ESTs]
    Unigene Representative Sequence: AK096962
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376861(uc010jrl.3 uc003nnm.4) ENST00000414333 ENST00000462777
    ENST00000259951(uc003nno.4) ENST00000489502 ENST00000482257 ENST00000434407
    ENST00000486194 ENST00000485513 ENST00000429294 ENST00000484704 ENST00000606273
    ENST00000465459 ENST00000475996(uc011dlx.1) ENST00000444621 ENST00000334668
    ENST00000440587(uc011dly.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HLA-F using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate HLA-F
    SwitchGear 3'UTR luciferase reporter plasmidHLA-F 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HLA-F
    Predesigned siRNA for gene silencing in human, mouse, rat HLA-F
    Clone
    Products:
         
    OriGene clones in human, mouse for HLA-F (see all 18)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): HLA-F (NM_001098478)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-F
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-F
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HLA-F
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-F
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HLA-F
      QuantiTect SYBR Green Assays in human, mouse, rat HLA-F
      QuantiFast Probe-based Assays in human, mouse, rat HLA-F

    Additional mRNA sequence: 

    AK096962.1 AK125274.1 AK225185.1 AK298704.1 AK300090.1 AK301488.1 AK302420.1 AK303670.1 
    AK309156.1 AY216682.1 AY221102.1 AY253269.1 AY253270.1 AY253271.1 BC009260.2 BC062991.1 
    DQ367723.1 GQ891552.1 

    Selected DOTS entries (see all 40):

    DT.121346401  DT.121346314  DT.100856917  DT.455506  DT.108834  DT.121346207  DT.100825996  DT.100042764 
    DT.315161  DT.121345652  DT.121346277  DT.40309926  DT.91783982  DT.92453534  DT.100825994  DT.95306295 
    DT.100036944  DT.100859573  DT.121346130  DT.95376339  DT.95376642  DT.100733427  DT.121346040  DT.121346112 

    23 AceView cDNA sequences:

    AY253270 AY253271 NM_018950 BC009260 AW610235 AK096962 BF477881 AY221102 
    BC062991 BQ016533 AY216682 AY253269 AA988615 AK125274 BE328079 BF110304 
    BE765149 CD629526 AW993267 BE764966 AA847453 BF807762 AW820588 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HLA-F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCAGCACGA
    HLA-F Expression
    About this image


    HLA-F expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
     
     Stomach (Gastrointestinal Tract)
     
     Spleen (Hematopoietic System)
    HLA-F Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HLA-F Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519972
        Custom PCR Arrays for HLA-F
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HLA-F
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-F
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HLA-F
    QuantiTect SYBR Green Assays in human, mouse, rat HLA-F
    QuantiFast Probe-based Assays in human, mouse, rat HLA-F
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-F

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for HLA-F gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm111275
    Gm70301
    predicted gene 111275
    predicted gene 70301
    74.52(n)1
    67.57(a)1
      17 (18.88 cM)5
    6302941  NM_001177467.11  NP_001170938.11 
     360558165 


    ENSEMBL Gene Tree for HLA-F (if available)
    TreeFam Gene Tree for HLA-F (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HLA-F gene
    MR12  FCGRT2  HFE2  HLA-B2  HLA-E2  HLA-C2  HLA-A2  HLA-G2  
    AZGP12  
    Selected SIMAP similar genes for HLA-F using alignment to 14 protein entries:     HLAF_HUMAN (see all proteins) (see all similar genes):
    HLA-A*0201V3    HLA-ABC    HLA-Cw3    HLA-A24AK    HLA C*    HLA-B41
    B*56    B-1510    HLA-A*01    HLA-B*27    HLA-B*1513    Cw
    HLA-A*33    HLA-A*02    HLA-A*0226    MHC class I HLA-A    HLA G locus    B-3501

    Find genes that share paralogs with HLA-F           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for HLA-F (see all 65)
    PGOHUM00000238621 PGOHUM00000238662 PGOHUM00000238789 PGOHUM00000238906 PGOHUM00000242166


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HLA-F (see all 211)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs92581671,2
    C,F--29688973(+) AGCCAG/ATGTTT 3 -- us2k15Minor allele frequency- A:0.18MN WA NA EA 416
    rs92581681,2
    C,F,A,H--29689003(+) tcataC/Taaaag 3 -- us2k18Minor allele frequency- T:0.17NS EA MN WA NA 714
    rs37573241,2
    C,F,A,H--29689127(+) GATGCG/TATTAA 3 -- us2k1 tfbs326Minor allele frequency- T:0.22NS EA MN NA WA CSA 3116
    rs16329561,2
    C,F,A,H--29689164(-) TGTTGA/TCTAGT 3 -- us2k1 tfbs316Minor allele frequency- T:0.13NS EA NA MN WA CSA 849
    rs37573251,2
    C,F,A,H--29689202(+) CAGGTA/TTGCCC 3 -- us2k117Minor allele frequency- T:0.20NS EA MN NA WA 1560
    rs37573261,2
    C,F,A--29689249(+) CAAGAC/GCGAAG 3 -- us2k18Minor allele frequency- G:0.20MN NA WA EA 548
    rs69251431,2
    C,F--29689254(+) CCGAAG/CTGGAG 3 -- us2k16Minor allele frequency- C:0.10MN WA NA CSA 300
    rs1908214991,2
    --29689412(+) AGGGCA/CTGAGG 3 -- us2k10--------
    rs1440017831,2
    --29689423(+) GATGAA/GAGGGA 3 -- us2k10--------
    rs1464445441,2
    C--29689513(+) TTAAAC/TACATT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for HLA-F (29690552 - 29706305 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HLA-F:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1039e201CNV Deletion23290073
    nsv883531CNV Loss21882294
    nsv508397CNV Loss20534489
    nsv462673CNV Loss19166990
    nsv10809CNV Gain18304495
    nsv428139CNV Gain18775914
    esv25966CNV Gain+Loss19812545

    Locus Specific Mutation Databases (LSDB): HLA-F

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HLA-F
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-F

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 143110    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for HLA-F:
    Hemochromatosis

    Find genes that share disorders with HLA-F           About GenesLikeMe

    Genetic Association Database (GAD): HLA-F
    Human Genome Epidemiology (HuGE) Navigator: HLA-F (2815 documents)

    Export disorders for HLA-F gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HLA-F gene, integrated from 10 sources (see all 131):
    (articles sorted by number of sources associating them with HLA-F)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human leukocyte antigen F (HLA-F). An expressed HLA gene composed of a class I coding sequence linked to a novel transcribed repetitive element. (PubMed id 1688605)1, 2, 3, 9 Geraghty D.E.... Koller B.H. (J. Exp. Med. 1990)
    2. HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the nonclassical class I genes. (PubMed id 16570139)1, 2, 9 Pyo C.W.... Geraghty D.E. (Immunogenetics 2006)
    3. Genetic associations of common deletion polymorphisms in families with Avellino corneal dystrophy. (PubMed id 19622345)1, 4, 9 Park M....Kim H.L. (Biochem. Biophys. Res. Commun. 2009)
    4. SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. (PubMed id 17971048)1, 4, 9 Burfoot R.K....Rubio J.P. (Tissue Antigens 2008)
    5. A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. (PubMed id 20593013)1, 4 Cree B.A.... . (PLoS ONE 2010)
    6. Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3. (PubMed id 19664746)1, 4 Tse K.P....Shugart Y.Y. (Am. J. Hum. Genet. 2009)
    7. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    8. Identification of a novel HLA-F allele - HLA-F*010102. (PubMed id 14705989)1, 2 He X.... Zeng Y. (Tissue Antigens 2004)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    10. A 356-Kb sequence of the subtelomeric part of the MHC class I region. (PubMed id 10727083)1, 2 Hampe A.... Galibert F. (DNA Seq. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3134 HGNC: 4963 AceView: HLA-F Ensembl:ENSG00000204642 euGenes: HUgn3134
    ECgene: HLA-F Kegg: 3134 H-InvDB: HLA-F

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HLA-F Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HLA-F gene:
    Search GeneIP for patents involving HLA-F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HLA-F   OriGene RNAi products in human, mouse, rat for HLA-F  
     OriGene qPCR primer pairs and template standards for HLA-F   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HLA-F  
     OriGene qSTAR qPCR primer pairs in human, mouse for HLA-F   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HLA-F   OriGene Custom Protein Services for HLA-F  

     
     
     Block miRNA regulation of human, mouse, rat HLA-F using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HLA-F
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-F Predesigned siRNA for gene silencing in human, mouse, rat HLA-F
     QuantiFast Probe-based Assays in human, mouse, rat HLA-F QuantiTect SYBR Green Assays in human, mouse, rat HLA-F
     Custom PCR Arrays for HLA-F Search Chromatin IP Primers for HLA-F
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HLA-F  GeneGlobe Interaction Network for HLA-F
     Regulatory tfbs in HLA-F promoter
     GenScript Custom Purified and Recombinant Proteins Services for HLA-F GenScript cDNA clones with any tag delivered in your preferred vector for HLA-F
     GenScript Custom Assay Services for HLA-F GenScript Custom overexpressing Cell Line Services for HLA-F
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HLA-F (HLAF)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HLA-F antibodies
     Antibodies for HLA-F
     See all of Abcam's Antibodies, Kits and Proteins for HLA-F
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for HLA-F
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-F
     SwitchGear 3'UTR luciferase reporter plasmids for HLA-F
     SwitchGear Promoter luciferase reporter plasmids for HLA-F
     ThermoFisher Antibodies for HLA-F
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-F
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HLA-F
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HLA-F
     LSBio Antibodies in human, mouse, rat for HLA-F
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for HLA-F
      Search eBioscience for proteins for HLA-F
      Search eBioscience for elisas for HLA-F
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HLA-F gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4