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HLA-E Gene

protein-coding   GIFtS: 65
GCID: GC06P030457

Major Histocompatibility Complex, Class I, E

  Search for HLA-E
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Major Histocompatibility Complex, Class I, E1 2     HLA Class I Histocompatibility Antigen, Alpha Chain E2
HLA-6.22 3     HLA Class I Histocompatibility Antigen, E Alpha Chain2
MHC Class I Antigen E2 3     Lymphocyte Antigen2
EA1.22     MHC HLA-E Alpha-12
EA2.12     MHC HLA-E Alpha-2.12
MHC2     HLAE3
QA12     

External Ids:    HGNC: 49621   Entrez Gene: 31332   Ensembl: ENSG000002045927   OMIM: 1430105   UniProtKB: P137473   

Export aliases for HLA-E gene to outside databases

Previous GC identifers: GC06P030513 GC06P030228 GC06P030563 GC06P030565 GC06P030257


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HLA-E Gene:
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a
heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a
restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is
approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the
alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the
transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. (provided by RefSeq, Jul 2008)

GeneCards Summary for HLA-E Gene:
HLA-E (major histocompatibility complex, class I, E) is a protein-coding gene. GO annotations related to this gene include peptide antigen binding and receptor binding. An important paralog of this gene is HLA-F.

UniProtKB/Swiss-Prot: HLAE_HUMAN, P13747
Function: Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules

Gene Wiki entry for HLA-E Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  
NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HLA-E gene promoter:
         MEF-2A   AP-1   MyoD   STAT3   aMEF-2   Nkx2-5   NF-kappaB1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HLA-E promoter sequence
   Search Chromatin IP Primers for HLA-E

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

HLA-E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-E gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P030457:  view genomic region     (about GC identifiers)

Start:
30,457,183 bp from pter      End:
30,461,982 bp from pter
Size:
4,800 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,NT_167248 1,750,098-1,754,897      Chr6+,NT_167247 1,839,047-1,843,846      Chr6+,NT_167246 1,805,261-1,810,060     
Chr6+,NT_113891.2 1,969,247-1,974,046      Chr6+,NT_167245 1,750,823-1,755,622      Chr6+,NT_167249 1,789,473-1,794,272     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HLAE_HUMAN, P13747 (See protein sequence)
Recommended Name: HLA class I histocompatibility antigen, alpha chain E precursor  
Size: 358 amino acids; 40157 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin)
Caution: The existence of allele E*0102 (PubMed:3260916) and allele E*0104 (PubMed:1977695) is uncertain. The
alleles could not be confirmed in further studies (PubMed:12445303)
Selected PDB 3D structures from and Proteopedia for HLA-E (see all 9):
1KPR (3D)        1KTL (3D)        1MHE (3D)        2ESV (3D)        3AM8 (3D)        3BZE (3D)    
Secondary accessions: Q30169 Q9BT83 Q9GIY7 Q9GIY8

Explore the universe of human proteins at neXtProt for HLA-E: NX_P13747

Explore proteomics data for HLA-E at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys142, Lys167, Lys191, Lys264, Lys343
  • Glycosylation2 at Asn107
  • Modification sites at PhosphoSitePlus

  • See HLA-E Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005507.3  
    ENSEMBL proteins: 
     ENSP00000365817  
    Reactome Protein details: P13747

    HLA-E Human Recombinant Protein Products:

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    OriGene MassSpec for HLA-E
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    Novus Biologicals HLA-E Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HLA-E 

    HLA-E Antibody Products:

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    HLA-E Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for HLA-E 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HLA: Histocompatibility complex
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    Selected InterPro protein domains (see all 8):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P13747

    ProtoNet protein and cluster: P13747

    2 Blocks protein domains:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: HLAE_HUMAN, P13747
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Find genes that share domains with HLA-E           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HLAE_HUMAN, P13747
    Function: Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules

         Genatlas biochemistry entry for HLA-E:
    HLA class Ib,44kDa,6.2kb HindIII fragment,TAP and tapasin dependent,localized at the cell surface,harboring
    structural features conferring tight peptide binding specificity,correlating with the binding of an MHC class I
    leader peptide (see MHC1)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding IBA--
    GO:0005515protein binding ----
    GO:0042288MHC class I protein binding IDA9754572
    GO:0042605peptide antigen binding IDA9754572
         
    Find genes that share ontologies with HLA-E           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for H2-T23):
     hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with HLA-E           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out H2-T23H2-tm1Cant for HLA-E

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HLA-E
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HLA-E

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HLA-E
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HLA-E

    miRNA
    Products:
        
    miRTarBase miRNAs that target HLA-E:
    hsa-mir-296-3p (MIRT038407), hsa-mir-92a-3p (MIRT049514)

    Block miRNA regulation of human, mouse, rat HLA-E using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HLA-E:
    hsa-miR-4302
    SwitchGear 3'UTR luciferase reporter plasmidHLA-E 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HLA-E
    Predesigned siRNA for gene silencing in human, mouse, rat HLA-E

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HLA-E

    Clone
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    OriGene clones in human, mouse for HLA-E (see all 6)
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    GenScript: all cDNA clones in your preferred vector: HLA-E (NM_005516)
    Sino Biological Human cDNA Clone for HLA-E
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-E
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-E

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HLA-E 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-E


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HLAE_HUMAN, P13747: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    endosome4
    golgi apparatus4
    plasma membrane4
    extracellular2
    cytosol1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0009986cell surface IDA9754572
    GO:0012507ER to Golgi transport vesicle membrane TAS--
    GO:0030670phagocytic vesicle membrane TAS--

    Find genes that share ontologies with HLA-E           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HLA-E About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Allograft rejection0.86
    Autoimmune thyroid disease0.61
    Allograft Rejection0.86
    Viral myocarditis0.40
    Type I diabetes mellitus0.69
    CTL Mediated Apoptosis0.38
    Graft-versus-host disease0.65
    Antigen processing and presentation0.36
    2CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway0.80
    Proteasome Degradation0.57
    Antigen processing-Cross presentation0.80
    Endosomal/Vacuolar pathway0.00
    3Immune response Role of DAP12 receptors in NK cells
    Immune response Role of DAP12 receptors in NK cells0.33
    Natural killer cell mediated cytotoxicity0.31
    Immune response CD16 signaling in NK cells0.33
    4Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    5Signaling by FGFR
    DAP12 signaling0.89
    DAP12 interactions0.89


    Find genes that share SuperPaths with HLA-E           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HLA-E
        CDC42 Pathway
    CTL Mediated Apoptosis

    3 GeneGo (Thomson Reuters) Pathways for HLA-E
        Immune response CD16 signaling in NK cells
    Immune response Role of DAP12 receptors in NK cells
    Immune response Role of integrins in NK cells cytotoxicity

    2 BioSystems Pathways for HLA-E
        Allograft Rejection
    Proteasome Degradation

    1 Sino Biological Pathway for HLA-E
        NF-kB (NFkB) Pathway

    Selected Reactome Pathways for HLA-E (see all 8)
        Endosomal/Vacuolar pathway
    Interferon alpha/beta signaling
    Interferon gamma signaling
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell


    Selected Kegg Pathways  (Kegg details for HLA-E) (see all 14):
        Endocytosis
    Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Natural killer cell mediated cytotoxicity

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HLA-E: 
              Innate & Adaptive Immune Responses in human mouse rat
              Type I Interferon Response in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HLA-E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for HLA-E (P137473 ENSP000003658174) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B2MP617693, ENSP000003408584I2D: score=4 STRING: ENSP00000340858
    KLRD1Q132413, ENSP000003381304I2D: score=2 STRING: ENSP00000338130
    KLRC1P267153, ENSP000003520644I2D: score=1 STRING: ENSP00000352064
    KLRC2P267173, ENSP000003713274I2D: score=1 STRING: ENSP00000371327
    CD8AP017323, ENSP000002836354I2D: score=2 STRING: ENSP00000283635
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001916positive regulation of T cell mediated cytotoxicity IEA--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002476antigen processing and presentation of endogenous peptide antigen via MHC class Ib IDA9754572
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0002480antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS--

    Find genes that share ontologies with HLA-E           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HLA-E (HLAE)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HLA-E gene: 
    NM_005516.5  

    Unigene Cluster for HLA-E:

    Major histocompatibility complex, class I, E
    Hs.650174  [show with all ESTs]
    Unigene Representative Sequence: NM_005516
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376630(uc011dmg.2 uc003nqg.3 uc011dmh.2) ENST00000484194
    ENST00000493699
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate HLA-E:
    hsa-miR-4302
    SwitchGear 3'UTR luciferase reporter plasmidHLA-E 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HLA-E
    Predesigned siRNA for gene silencing in human, mouse, rat HLA-E
    Clone
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HLA-E
      QuantiTect SYBR Green Assays in human, mouse, rat HLA-E
      QuantiFast Probe-based Assays in human, mouse, rat HLA-E

    Additional mRNA sequence: 

    AB209870.1 AJ293263.1 AJ293264.1 AK098434.1 AK225048.1 AK292391.1 AK296822.1 AK298695.1 
    AK301125.1 AK314411.1 AY216681.1 AY221103.1 BC002578.2 BC004297.1 BC040479.1 BX538084.1 
    L78455.1 L78934.1 M20022.1 M31183.1 X56841.1 X64879.1 

    Selected DOTS entries (see all 80):

    DT.91764483  DT.95245447  DT.100061168  DT.91740240  DT.91764506  DT.95245445  DT.121346331  DT.95245417 
    DT.95245415  DT.87005617  DT.95245421  DT.121346247  DT.121345787  DT.121346421  DT.121346111  DT.101988044 
    DT.91671107  DT.91831076  DT.100049205  DT.121346187  DT.121345720  DT.91954591  DT.92024656  DT.97811367 

    Selected AceView cDNA sequences (see all 1003):

    AA342673 BG754928 BM562466 BM990261 BM822513 BG028524 BG025728 BQ052237 
    BX538084 BG232060 AI204037 AI356101 BG055690 AA085553 BQ717597 AI818330 
    BE222580 AJ293263 AA909748 CA439069 CA307300 AI284570 CA406763 AW236295 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HLA-E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCTTTAAC
    HLA-E Expression
    About this image


    HLA-E expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T Helper Cells Thymus
     
     Spleen (Hematopoietic System)
    HLA-E Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HLA-E Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.650174
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HLA-E: 
              Innate & Adaptive Immune Responses in human mouse rat
              Type I Interferon Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HLA-E
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-E
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HLA-E
    QuantiTect SYBR Green Assays in human, mouse, rat HLA-E
    QuantiFast Probe-based Assays in human, mouse, rat HLA-E
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-E

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for HLA-E gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia H2-T231 , 5 histocompatibility 2, T region locus 231, 5 79.5(n)1
    71.28(a)1
      17 (18.86 cM)5
    150401  NM_010398.31  NP_034528.11 
     360297735 


    ENSEMBL Gene Tree for HLA-E (if available)
    TreeFam Gene Tree for HLA-E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HLA-E gene
    HLA-F2  FCGRT2  HLA-A2  MR12  HLA-B2  HFE2  HLA-C2  AZGP12  
    HLA-G2  
    Selected SIMAP similar genes for HLA-E using alignment to 14 protein entries:     HLAE_HUMAN (see all proteins) (see all similar genes):
    EA1.2    EA2.1    DKFZp686P19218    HLA-A*0201V3    HLA-ABC    HLA-Cw2
    Cw*03    HLA-Cw3    HLA G locus    HLA-B41    HLA-B*15IL    FLJ45422
    HLA C*    HLA-B27    B-1510    MHC-G    HLA-Cw*    HLA-Bw62.5

    Find genes that share paralogs with HLA-E           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    HLAE_HUMAN, P13747: The following alleles of E-1 are known: E*01:01, E*0102, E*01:03 and E*01:04. The sequence shown is
    that of E*01:01


    Selected SNPs for HLA-E (see all 223)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1394228601,2
    C--30455186(+) TCATCA/GCAACC 1 -- us2k10--------
    rs178753591,2
    C,F--30455203(+) TCCCGG/AGTTCA 1 -- us2k13Minor allele frequency- A:0.10MN NA 70
    rs287801081,2
    C,F--30455240(+) AGTAGG/CTGGGA 1 -- us2k13Minor allele frequency- C:0.06NA 124
    rs122079741,2
    C,A--30455294(+) gtagaG/Catggg 1 -- us2k12Minor allele frequency- C:0.25WA NA 4
    rs178753601,2
    C--30455321(+) AAGGCT/CGGTCT 1 -- us2k15Minor allele frequency- C:0.11MN WA NA EA 426
    rs1395552151,2
    C--30455364(+) ACCGCG/TCCTGG 1 -- us2k10--------
    rs1812115601,2
    --30455384(+) GTATCG/TAAAAT 1 -- us2k10--------
    rs1475907791,2
    C--30455429(+) AATGTA/GTGCTA 1 -- us2k10--------
    rs178753611,2
    C--30455468(+) TGCAAC/GAACAA 1 -- us2k1 tfbs31Minor allele frequency- G:0.01MN 66
    rs37573351,2
    C,F,H--30455532(+) CTGCAG/TAAGGT 1 -- us2k16Minor allele frequency- T:0.06EA NS 2014

    HapMap Linkage Disequilibrium report for HLA-E (30457183 - 30461982 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for HLA-E:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731791CNV Deletion23290073
    nsv5242CNV Insertion18451855
    nsv884070CNV Loss21882294
    dgv6523n71CNV Loss21882294
    nsv884077CNV Loss21882294
    nsv884076CNV Gain21882294

    Human Gene Mutation Database (HGMD): HLA-E
    Locus Specific Mutation Databases (LSDB): HLA-E

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HLA-E
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-E

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 143010    OMIM disorders: --


    Find genes that share disorders with HLA-E           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HLA-E gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    miscarriage recurrent 49 5 16514201 (3), 11270642 (2)
    choriocarcinoma 47.6 4 15578261 (1), 19239424 (1), 11884433 (1)
    infection chronic 45.4 1 15751767 (1)
    miscarriage 44.4 4 9894856 (3)
    autoimmune diseases 4.36 2 19140831 (1), 10689118 (1)
    myeloma 2.33 4 1402654 (1), 9574542 (1)
    leukemia 0 2 11870233 (1)
    necrosis 0 4 11870233 (1), 17179229 (1)
    tumors 0 32 12618909 (9), 15620456 (4), 20167379 (3), 16920947 (2) (see all 12)
    preeclampsia 0 1 16806485 (1)

    Genetic Association Database (GAD): HLA-E
    Human Genome Epidemiology (HuGE) Navigator: HLA-E (2817 documents)

    Export disorders for HLA-E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HLA-E gene, integrated from 10 sources (see all 313):
    (articles sorted by number of sources associating them with HLA-E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene. (PubMed id 3131426)1, 2, 3 Mizuno S.... Yang S.Y. (J. Immunol. 1988)
    2. [Analysis on HLA-E polymorphism in Guangdong Han population]. (PubMed id 15631661)1, 4, 9 Zhen Z.J....Huang S.L. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2004)
    3. HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms. (PubMed id 19180512)1, 4, 9 Lin Y.J....Tsai F.J. (Arthritis Rheum. 2009)
    4. Ethnic variability in human leukocyte antigen-E haplotypes. (PubMed id 19140831)1, 4, 9 Antoun A....Briggs D. (Tissue Antigens 2009)
    5. HLA-G and HLA-E polymorphisms in an indigenous African population. The ZVITAMBO Study Group. (PubMed id 11137220)1, 4, 9 Matte C....Roger M. (Hum. Immunol. 2000)
    6. Homozygous status for HLA-E*0103 confers protection from acute graft-versus-host disease and transplant-related mortality in HLA-matched sibling hematopoietic stem cell transplantation. (PubMed id 17164714)1, 4, 9 Tamouza R....Charron D. (Transplantation 2006)
    7. HLA-E and immunobiology of pregnancy. (PubMed id 16573557)1, 4, 9 Tripathi P....Agrawal S. (Tissue Antigens 2006)
    8. Genetic variants in nonclassical major histocompatibility complex class I human leukocyte antigen (HLA)-E and HLA-G molecules are associated with susceptibility to heterosexual acquisition of HIV-1. (PubMed id 16362895)1, 4, 9 Lajoie J....Roger M. (J. Infect. Dis. 2006)
    9. Polymorphism of human leukocyte antigen-E gene in the Japanese population with or without recurrent abortion. (PubMed id 11270642)1, 4, 9 Kanai T....Taketani Y. (Am. J. Reprod. Immunol. 2001)
    10. HLA-E*0101 and HLA-G*010101 reduce the risk of Behcet's disease. (PubMed id 17257316)1, 4, 9 Park K.S....Lee E.S. (Tissue Antigens 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3133 HGNC: 4962 AceView: HLA-EandRANP1andFLJ45422 Ensembl:ENSG00000204592 euGenes: HUgn3133
    ECgene: HLA-E Kegg: 3133 H-InvDB: HLA-E

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HLA-E Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HLA-E gene:
    Search GeneIP for patents involving HLA-E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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