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Aliases for HLA-E Gene

Aliases for HLA-E Gene

  • Major Histocompatibility Complex, Class I, E 2 3
  • MHC Class I Antigen E 3 4
  • HLA-6.2 3 4
  • HLA Class I Histocompatibility Antigen, E Alpha Chain 3
  • MHC HLA-E Alpha-2.1 3
  • Lymphocyte Antigen 3
  • MHC HLA-E Alpha-1 3
  • EA1.2 3
  • EA2.1 3
  • HLAE 4
  • MHC 3
  • QA1 3

External Ids for HLA-E Gene

Previous GeneCards Identifiers for HLA-E Gene

  • GC06P030513
  • GC06P030228
  • GC06P030563
  • GC06P030565
  • GC06P030457
  • GC06P030257

Summaries for HLA-E Gene

Entrez Gene Summary for HLA-E Gene

  • HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-E Gene

HLA-E (Major Histocompatibility Complex, Class I, E) is a Protein Coding gene. Diseases associated with HLA-E include behcet's disease. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include receptor binding and MHC class I protein binding. An important paralog of this gene is MR1.

UniProtKB/Swiss-Prot for HLA-E Gene

  • Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules

Gene Wiki entry for HLA-E Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-E Gene

Genomics for HLA-E Gene

Regulatory Elements for HLA-E Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HLA-E Gene

Chromosome:
6
Start:
30,489,406 bp from pter
End:
30,494,205 bp from pter
Size:
4,800 bases
Orientation:
Plus strand

Genomic View for HLA-E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HLA-E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-E Gene

  • Protein details for HLA-E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13747-HLAE_HUMAN
    Recommended name:
    HLA class I histocompatibility antigen, alpha chain E
    Protein Accession:
    P13747
    Secondary Accessions:
    • Q30169
    • Q9BT83
    • Q9GIY7
    • Q9GIY8

    Protein attributes for HLA-E Gene

    Size:
    358 amino acids
    Molecular mass:
    40157 Da
    Quaternary structure:
    • Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin)

    Three dimensional structures from OCA and Proteopedia for HLA-E Gene

neXtProt entry for HLA-E Gene

Proteomics data for HLA-E Gene at MOPED

Post-translational modifications for HLA-E Gene

  • Ubiquitination at Lys 142, Lys 167, Lys 191, and Lys 343
  • Glycosylation at Asn 107
  • Modification sites at PhosphoSitePlus

Other Protein References for HLA-E Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HLA-E Gene

Domains & Families for HLA-E Gene

Gene Families for HLA-E Gene

Graphical View of Domain Structure for InterPro Entry

P13747

UniProtKB/Swiss-Prot:

HLAE_HUMAN :
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Belongs to the MHC class I family.
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with HLA-E: view

Function for HLA-E Gene

Molecular function for HLA-E Gene

GENATLAS Biochemistry:
HLA class Ib,44kDa,6.2kb HindIII fragment,TAP and tapasin dependent,localized at the cell surface,harboring structural features conferring tight peptide binding specificity,correlating with the binding of an MHC class I leader peptide (see MHC1)
UniProtKB/Swiss-Prot Function:
Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules

Gene Ontology (GO) - Molecular Function for HLA-E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 18448674
GO:0005515 protein binding --
GO:0030881 beta-2-microglobulin binding IMP 12411439
GO:0042288 MHC class I protein binding IDA 9754572
GO:0042605 peptide antigen binding IMP 12411439
genes like me logo Genes that share ontologies with HLA-E: view
genes like me logo Genes that share phenotypes with HLA-E: view

Animal Models for HLA-E Gene

MGI Knock Outs for HLA-E:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HLA-E

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HLA-E Gene

Localization for HLA-E Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-E Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HLA-E Gene COMPARTMENTS Subcellular localization image for HLA-E gene
Compartment Confidence
endoplasmic reticulum 2
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HLA-E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IDA 9754572
GO:0012507 ER to Golgi transport vesicle membrane TAS --
GO:0030670 phagocytic vesicle membrane TAS --
genes like me logo Genes that share ontologies with HLA-E: view

Pathways & Interactions for HLA-E Gene

genes like me logo Genes that share pathways with HLA-E: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Innate & Adaptive Immune Responses in human,mouse,rat
    • Type I Interferon Response in human,mouse,rat

Gene Ontology (GO) - Biological Process for HLA-E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity IDA 25631937
GO:0002250 adaptive immune response IDA 25631937
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib IDA 9754572
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
genes like me logo Genes that share ontologies with HLA-E: view

No data available for SIGNOR curated interactions for HLA-E Gene

Drugs & Compounds for HLA-E Gene

No Compound Related Data Available

Transcripts for HLA-E Gene

mRNA/cDNA for HLA-E Gene

Unigene Clusters for HLA-E Gene

Major histocompatibility complex, class I, E:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HLA-E

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-E Gene

No ASD Table

Relevant External Links for HLA-E Gene

GeneLoc Exon Structure for
HLA-E
ECgene alternative splicing isoforms for
HLA-E

Expression for HLA-E Gene

mRNA expression in normal human tissues for HLA-E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-E Gene

This gene is overexpressed in Whole Blood (x12.7).

Protein differential expression in normal tissues from HIPED for HLA-E Gene

This gene is overexpressed in Skin (26.3) and Peripheral blood mononuclear cells (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HLA-E Gene



SOURCE GeneReport for Unigene cluster for HLA-E Gene Hs.650174

genes like me logo Genes that share expression patterns with HLA-E: view

Protein tissue co-expression partners for HLA-E Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HLA-E Gene

Orthologs for HLA-E Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for HLA-E Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia H2-T23 35
  • 79.5 (n)
  • 71.28 (a)
H2-T23 16
chimpanzee
(Pan troglodytes)
Mammalia PATR-E 35
  • 98.67 (n)
  • 98 (a)
PATR-E 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RT1-S3 35
  • 77.97 (n)
  • 69.86 (a)
Species with no ortholog for HLA-E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HLA-E Gene

ENSEMBL:
Gene Tree for HLA-E (if available)
TreeFam:
Gene Tree for HLA-E (if available)

Paralogs for HLA-E Gene

Paralogs for HLA-E Gene

genes like me logo Genes that share paralogs with HLA-E: view

Variants for HLA-E Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-E Gene

P13747-HLAE_HUMAN
The following alleles of E-1 are known: E*01:01, E*0102, E*01:03 and E*01:04. The sequence shown is that of E*01:01

Sequence variations from dbSNP and Humsavar for HLA-E Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_059510 -
VAR_016652 -
VAR_016651 -
VAR_004395 -

Structural Variations from Database of Genomic Variants (DGV) for HLA-E Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
nsv884070 CNV Loss 21882294
nsv884076 CNV Gain 21882294
nsv884077 CNV Loss 21882294
dgv6523n71 CNV Loss 21882294
nsv5242 CNV Insertion 18451855

Variation tolerance for HLA-E Gene

Residual Variation Intolerance Score: 63.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.79; 33.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HLA-E Gene

HapMap Linkage Disequilibrium report
HLA-E
Human Gene Mutation Database (HGMD)
HLA-E

Disorders for HLA-E Gene

MalaCards: The human disease database

(1) MalaCards diseases for HLA-E Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
behcet's disease
  • adamantiades-behcet disease
- elite association
Search HLA-E in MalaCards View complete list of genes associated with diseases

Relevant External Links for HLA-E

Genetic Association Database (GAD)
HLA-E
Human Genome Epidemiology (HuGE) Navigator
HLA-E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HLA-E
genes like me logo Genes that share disorders with HLA-E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HLA-E Gene

Publications for HLA-E Gene

  1. CD94/NKG2C is a killer effector molecule in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis. (PMID: 20132973) Morel E. … BellA^n T. (J. Allergy Clin. Immunol. 2010) 23 67
  2. Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: a role in innate immunity? (PMID: 20167379) Kren L. … Michalek J. (J. Neuroimmunol. 2010) 23 67
  3. HLA-E upregulation on IFN-gamma-activated AML blasts impairs CD94/NKG2A-dependent NK cytolysis after haplo-mismatched hematopoietic SCT. (PMID: 19011664) Nguyen S. … Vieillard V. (Bone Marrow Transplant. 2009) 23 67
  4. HLA-E/human beta2-microglobulin transgenic pigs: protection against xenogeneic human anti-pig natural killer cell cytotoxicity. (PMID: 19136889) Weiss E.H. … Brem G. (Transplantation 2009) 23 67
  5. Effect of progesterone on HLA-E gene expression in JEG-3 choriocarcinoma cell line. (PMID: 19239424) Huang Z. … Taketani Y. (Am. J. Reprod. Immunol. 2009) 23 67

Products for HLA-E Gene

Sources for HLA-E Gene

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