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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLA-E Gene

protein-coding   GIFtS: 61
GCID: GC06P030457

major histocompatibility complex, class I, E
 Explore 58 diseases affiliated with
HLA-E via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HLA-E    

Aliases
for HLA-E gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Major Histocompatibility Complex, Class I, E1 2     HLA Class I Histocompatibility Antigen, Alpha Chain E2
HLA-6.22 3     HLA Class I Histocompatibility Antigen, E Alpha Chain2
MHC Class I Antigen E2 3     Lymphocyte Antigen2
EA1.22     MHC HLA-E Alpha-12
EA2.12     MHC HLA-E Alpha-2.12
MHC2     HLAE3
QA12     

External Ids:    HGNC: 49621   Entrez Gene: 31332   Ensembl: ENSG000002045927   OMIM: 1430105   UniProtKB: P137473   

Export aliases for HLA-E gene to outside databases

Previous GC identifers: GC06P030513 GC06P030228 GC06P030563 GC06P030565 GC06P030257


Summaries
for HLA-E gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HLA-E:
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy
chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted
subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45
kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2
domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and
exons 6 and 7 encode the cytoplasmic tail. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HLAE_HUMAN, P13747
Function: Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules

Gene Wiki entry for HLA-E


Genomic Views
for HLA-E gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLA-E gene promoter:
         MEF-2A   AP-1   MyoD   STAT3   aMEF-2   Nkx2-5   NF-kappaB1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HLA-E promoter sequence
   Search SABiosciences Chromatin IP Primers for HLA-E

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.3

HLA-E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-E gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P030457:  view genomic region     (about GC identifiers)

Start:
 30,457,183 bp from pter      End:
 30,461,982 bp from pter
Size:
 4,800 bases      Orientation:
 plus strand

6 alternative locations:
Chr6+,ALT_REF_LOCI_3 30,447,487-30,463,263      Chr6+,ALT_REF_LOCI_6 30,446,762-30,487,081      Chr6+,ALT_REF_LOCI_4 30,424,920-30,429,719     
Chr6+,ALT_REF_LOCI_5 30,450,470-30,455,269      Chr6+,ALT_REF_LOCI_2 30,447,104-30,491,030      Chr6+,ALT_REF_LOCI_7 30,378,938-30,383,737     

Proteins
for HLA-E gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HLAE_HUMAN, P13747 (See protein sequence)
Recommended Name: HLA class I histocompatibility antigen, alpha chain E precursor  
Size: 358 amino acids; 40157 Da
Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin)
Subcellular location: Membrane; Single-pass type I membrane protein
Caution: The existence of allele E*0102 (PubMed:3260916) and allele E*0104 (PubMed:1977695) is uncertain. The alleles
could not be confirmed in further studies (PubMed:12445303)
6/9 PDB 3D structures from and Proteopedia for HLA-E (see all 9):
1KPR (3D)        1KTL (3D)        1MHE (3D)        2ESV (3D)        3AM8 (3D)        3BZE (3D)    
Secondary accessions: Q30169 Q9BT83 Q9GIY7 Q9GIY8

Explore the universe of human proteins at neXtProt for HLA-E: NX_P13747

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P13747

    • HLA-E Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005507.3  
    ENSEMBL proteins: 
     ENSP00000365817  
    Reactome Protein details: P13747
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: HLA-E
    OriGene Protein Over-expression Lysate: HLA-E
    OriGene Custom Protein Services for HLA-E 
    GenScript Custom Purified and Recombinant Proteins Services for HLA-E
    Novus Biologicals HLA-E Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HLA-E

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0012507ER to Golgi transport vesicle membrane TAS--
    GO:0030670phagocytic vesicle membrane TAS--
    GO:0031901early endosome membrane TAS--


    HLA-E for ontologies           About GeneDecksing



    HLA-E Antibody Products: 
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    OriGene Custom Antibody Services for HLA-E 
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    Novus Biologicals HLA-E Antibodies
    Abcam antibodies for HLA-E 
    Uscn Antibodies for HLA-E
    Search ThermoFisher Antibodies for HLA-E

    Assay Products for HLA-E: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HLA-E
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HLA-E

    Protein Domains /
    Families
    for HLA-E gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HLA-E for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR003597 Ig_C1-set
     IPR007110 Ig-like_dom
     IPR003006 Ig/MHC_CS

    Graphical View of Domain Structure for InterPro Entry P13747

    ProtoNet protein and cluster: P13747

    2 Blocks protein families:
    IPB001039 MHC class I signature
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: HLAE_HUMAN, P13747
    Similarity: Belongs to the MHC class I family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Function
    for HLA-E gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HLAE_HUMAN, P13747
    Function: Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules

         Genatlas biochemistry entry for HLA-E:
    HLA class Ib,44kDa,6.2kb HindIII fragment,TAP and tapasin dependent,localized at the cell surface,harboring structural
    features conferring tight peptide binding specificity,correlating with the binding of an MHC class I leader peptide
    (see MHC1)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: HLA-E
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-E
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HLA-E:
    hsa-miR-4302
    SwitchGear 3'UTR luciferase reporter plasmid: HLA-E 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLA-E
    OriGene shRNA RFP: HLA-E
    OriGene siRNA: HLA-E
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-E

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HLA-E

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-E
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-E (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HLA-E (NM_005516)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-E
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-E 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HLA-E
    Search LifeMap BioReagents cell lines for HLA-E

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-E

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032393MHC class I receptor activity TAS3260916


    HLA-E for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out H2-T23H2-tm1Cant for HLA-E
         2 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for H2-T23):
     homeostasis/metabolism  immune system 

    HLA-E for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HLA-E gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Translocation of peptide bound MHC class I complex to cell surface
    		Translocation of peptide bound MHC class I complex to cell surface1.00
    		Endosomal/Vacuolar pathway0.78
    		Journey of cargo through Golgi complex1.00
    		Peptide loading on MHC class I in phagosome0.70
    		Expression of peptide bound class I MHC on cell surface1.00
    		Antigen Presentation: Folding, assembly and peptide loading of class I MHC0.28
    		Export of peptide loaded MHC class I complex to PM1.00
    2Allograft rejection
    		Allograft rejection1.00
    		CTL Mediated Apoptosis0.38
    		Type I diabetes mellitus0.67
    		Viral myocarditis0.33
    		Graft-versus-host disease0.63
    		Antigen processing and presentation0.25
    		Autoimmune thyroid disease0.60
    3Immune response CD16 signaling in NK cells
    		Immune response CD16 signaling in NK cells1.00
    		Immune response_Role of DAP12 receptors in NK cells0.32
    		Immune response_CD16 signaling in NK cells0.99
    		Immune response Role of DAP12 receptors in NK cells0.32
    4Immune System
    		Immune System1.00
    		Innate Immune System0.46
    		Adaptive Immune System0.59
    5Ubiquitinated Orc1 is degraded by the proteasome
    		ER-Phagosome pathway0.74
    		Proteasome Degradation0.56
    		Antigen processing-Cross presentation0.60

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for HLA-E
        Immune response Role of integrins in NK cells cytotoxicity
    Immune response CD16 signaling in NK cells
    Immune response Role of DAP12 receptors in NK cells

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HLA-E
        CDC42 Pathway
    CTL Mediated Apoptosis

    3 GeneGo (Thomson Reuters) Pathways for HLA-E
        Immune response CD16 signaling in NK cells
    Immune response Role of DAP12 receptors in NK cells
    Immune response Role of integrins in NK cells cytotoxicity

    1 BioSystems Pathway for HLA-E 
        Proteasome Degradation

    5/22        Reactome Pathways for HLA-E (see all 22)
        Endosomal/Vacuolar pathway
    Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Interferon alpha/beta signaling
    Expression of IFN-induced genes
    ER-Phagosome pathway


    5/10         Kegg Pathways  (Kegg details for HLA-E) (see all 10):
        Endocytosis
    Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Natural killer cell mediated cytotoxicity


    HLA-E for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLA-E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for HLA-E (P137473 ENSP000003658174) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B2MP617693, ENSP000003408584I2D: score=4 STRING: ENSP00000340858
    KLRD1Q132413, ENSP000003381304I2D: score=2 STRING: ENSP00000338130
    KLRC1P267153, ENSP000003520644I2D: score=1 STRING: ENSP00000352064
    KLRC2P267173, ENSP000003713274I2D: score=1 STRING: ENSP00000371327
    CD8AP017323, ENSP000002836354I2D: score=2 STRING: ENSP00000283635
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0002480antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent TAS--
    GO:0006955immune response ----
    GO:0019221cytokine-mediated signaling pathway TAS--


    HLA-E for ontologies           About GeneDecksing



    Drugs & Compounds
    for HLA-E gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HLA-E
    Search CenterWatch for drugs/clinical trials and news about HLA-E / HLAE 

    Transcripts
    for HLA-E gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HLA-E gene: 
    NM_005516.5  

    Unigene Cluster for HLA-E:

    Major histocompatibility complex, class I, E
    Hs.650174  [show with all ESTs]
    Unigene Representative Sequence: NM_005516
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376630(uc011dmg.2 uc003nqg.3 uc011dmh.2) ENST00000484194
    ENST00000493699

    miRNA
    Products:             		 OriGene 3'-UTR Clone: HLA-E
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-E
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HLA-E:
    hsa-miR-4302
    SwitchGear 3'UTR luciferase reporter plasmid: HLA-E 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLA-E
    OriGene shRNA RFP: HLA-E
    OriGene siRNA: HLA-E
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-E
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-E (see all 2)
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    GenScript: all cDNA clones in your preferred vector: HLA-E (NM_005516)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-E
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-E 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HLA-E
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-E
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-E

    Additional cDNA sequence: 

    AB209870.1 AJ293263.1 AJ293264.1 AK098434.1 AK225048.1 AK292391.1 AK296822.1 AK298695.1 
    AK301125.1 AK314411.1 AY216681.1 AY221103.1 BC002578.2 BC004297.1 BC040479.1 BX538084.1 
    L78455.1 L78934.1 M20022.1 M31183.1 X56841.1 X64879.1 

    24/80 DOTS entries (see all 80):

    DT.91764483  DT.95245447  DT.100061168  DT.91740240  DT.91764506  DT.95245445  DT.121346331  DT.95245417 
    DT.95245415  DT.87005617  DT.95245421  DT.121346247  DT.121345787  DT.121346421  DT.121346111  DT.101988044 
    DT.91671107  DT.91831076  DT.100049205  DT.121346187  DT.121345720  DT.91954591  DT.92024656  DT.97811367 

    24/1003 AceView cDNA sequences (see all 1003):

    BU615957 AA443611 BM911840 BI818829 AW117358 BM555389 BM803187 AA196126 
    BQ052969 BQ016582 CD368526 BG698804 AW303593 AA350145 BQ690219 BQ639905 
    BM688592 AW402463 BQ431807 CA412519 BQ052629 BQ000024 AJ293263 BM989102 

    GeneLoc Exon Structure


    Expression
    for HLA-E gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HLA-E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCCTTTAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HLA-E Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HLA-E

    SOURCE GeneReport for Unigene cluster: Hs.650174
        SABiosciences Expression via Pathway-Focused PCR Arrays including HLA-E: 
              Innate & Adaptive Immune Responses in human mouse rat
              Type I Interferon Response in human mouse rat

    Primer
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-E
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-E
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-E

    Orthologs
    for HLA-E gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-E gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NM79_CHICK6
    --
    (see all 15)    		 --
    		 39(a)
    38(a)
    (see all 15)    		 many ↔ many
    many ↔ many
    (see all 15)    		 16(40458-41204)
    16(204323-205564)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 25)    		 --
    		 45(a)
    44(a)
    (see all 25)    		 many ↔ many
    many ↔ many
    (see all 25)    		 AAWZ02039289(783-2823)
    AAWZ02038573(7605-9645)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:641151 zgc:64115 46.48(n)
    35.09(a)    		   791453  NM_001110118.1  NP_001103588.1 


    ENSEMBL Gene Tree for HLA-E (if available)
    TreeFam Gene Tree for HLA-E (if available) 

    Paralogs
    for HLA-E gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HLA-E gene
    HLA-F2  MR12  HFE2  HLA-B2  FCGRT2  HLA-C2  HLA-A2  HLA-G2  
    18/111 SIMAP similar genes for HLA-E using alignment to 11 protein entries:     HLAE_HUMAN (see all proteins) (see all similar genes):
    EA1.2    EA2.1    DKFZp686P19218    HLA-A*0201V3    HLA-ABC    HLA-Cw2
    Cw*03    HLA-Cw3    HLA-B41    HLA G locus    HLA-B*15IL    FLJ45422
    B-1510    HLA C*    HLA-Cw*    MHC-G    HLA-Bw62.5    Cw

    HLA-E for paralogs           About GeneDecksing



    Genomic Variants
    for HLA-E gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: HLAE_HUMAN, P13747
    Polymorphism: The following alleles of E-1 are known: E*01:01, E*0102, E*01:03 and E*01:04. The sequence shown is that
    of E*01:01


    10/158 NCBI SNPs in HLA-E are shown (see all 158)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1394228601,2
    		--30455186(+) TCATCA/GCAACC 1 -- us2k10--------
    rs178753591,2
    		C,F,--30455203(+) TCCCGG/AGTTCA 1 -- us2k13Minor allele frequency- A:0.10MN NA 70
    rs287801081,2
    		C,F,--30455240(+) AGTAGG/CTGGGA 1 -- us2k13Minor allele frequency- C:0.06NA 124
    rs122079741,2
    		C,A,--30455294(+) gtagaG/Catggg 1 -- us2k12Minor allele frequency- C:0.25WA NA 4
    rs178753601,2
    		C,--30455321(+) AAGGCT/CGGTCT 1 -- us2k15Minor allele frequency- C:0.11MN WA NA EA 426
    rs1395552151,2
    		C,--30455364(+) ACCGCG/TCCTGG 1 -- us2k10--------
    rs1812115601,2
    		--30455384(+) GTATCG/TAAAAT 1 -- us2k10--------
    rs1475907791,2
    		--30455429(+) AATGTA/GTGCTA 1 -- us2k10--------
    rs178753611,2
    		C--30455468(+) TGCAAC/GAACAA 1 -- us2k1 tfbs31Minor allele frequency- G:0.01MN 66
    rs37573351,2
    		C,F,H,--30455532(+) CTGCAG/TAAGGT 1 -- us2k16Minor allele frequency- T:0.06EA NS 2014

    HapMap Linkage Disequilibrium report for HLA-E (30457183 - 30461982 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HLA-E: --
    Human Gene Mutation Database (HGMD): HLA-E

    Locus Specific Mutation Databases (LSDB): HLA-E

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-E
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-E

    Disorders / Diseases
    for HLA-E gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HLA-E for disorders           About GeneDecksing

    OMIM gene information: 143010    OMIM disorders: --

    20/58 diseases for HLA-E (see all 58):    About MalaCards
    toxic epidermal necrolysis    stevens-johnson syndrome    graft versus host disease    intrahepatic cholestasis
    coronary artery aneurysm    type 1 diabetes mellitus    intrahepatic cholestasis of pregnancy    primary biliary cirrhosis
    spontaneous abortion    myasthenia gravis    sickle cell anemia    systemic lupus erythematosus
    cholestasis    lupus erythematosus    cytomegalovirus infection    diabetes mellitus
    myasthenia    ulcerative colitis    kaposi's sarcoma    myocardial infarction

    10/12 Novoseek disease relationships for HLA-E gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    miscarriage recurrent 49 5 16514201 (3), 11270642 (2)
    choriocarcinoma 47.6 4 15578261 (1), 19239424 (1), 11884433 (1)
    infection chronic 45.4 1 15751767 (1)
    miscarriage 44.4 4 9894856 (3)
    autoimmune diseases 4.36 2 19140831 (1), 10689118 (1)
    myeloma 2.33 4 1402654 (1), 9574542 (1)
    leukemia 0 2 11870233 (1)
    necrosis 0 4 11870233 (1), 17179229 (1)
    tumors 0 32 12618909 (9), 15620456 (4), 20167379 (3), 16920947 (2) (see all 12)
    preeclampsia 0 1 16806485 (1)

    Genetic Association Database (GAD): HLA-E
    Human Genome Epidemiology (HuGE) Navigator: HLA-E (2817 documents)

    Export disorders for HLA-E gene to outside databases

    Publications
    for HLA-E gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HLA-E gene, integrated from 9 sources (see all 299):
    (articles sorted by number of sources associating them with HLA-E)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene. (PubMed id 3131426)1, 2, 3 Mizuno S.... Yang S.Y. (1988)
    2. [Analysis on HLA-E polymorphism in Guangdong Han population] (PubMed id 15631661)1, 4, 9 Zhen Z.J....Huang S.L. (2004)
    3. HLA-G and HLA-E polymorphisms in an indigenous African population. The ZVITAMBO Study Group. (PubMed id 11137220)1, 4, 9 Matte C....Roger M. (2000)
    4. Genetic variants in nonclassical major histocompatibility complex class I human leukocyte antigen (HLA)-E and HLA-G molecules are associated with susceptibility to heterosexual acquisition of HIV-1. (PubMed id 16362895)1, 4, 9 Lajoie J....Roger M. (2006)
    5. Polymorphism of human leukocyte antigen-E gene in the Japanese population with or without recurrent abortion. (PubMed id 11270642)1, 4, 9 Kanai T....Taketani Y. (2001)
    6. Association of HLA-E polymorphism with severe bacterial infection and early transplant-related mortality in matched unrelated bone marrow transplantation. (PubMed id 16003246)1, 4, 9 Tamouza R....Charron D. (2005)
    7. HLA-E polymorphism in patients with nasopharyngeal carcinoma. (PubMed id 15496202)1, 4 Hirankarn N....Mutirangura A. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Distribution of human leukocyte antigens-E alleles in Thailand. (PubMed id 12929994)1, 4 Kimkong I....Pimtanothai N. (2003)
    10. [Analysis on HLA-E polymorphism in Shanghai Han population] (PubMed id 11774212)1, 4 Zhao L....Xu L. (2001)

    External Searches for HLA-E gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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    Genome Databases showing HLA-E gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3133 HGNC: 4962 AceView: HLA-EandRANP1andFLJ45422 Ensembl:ENSG00000204592 euGenes: HUgn3133
    ECgene: HLA-E Kegg: 3133 H-InvDB: HLA-E

    Other Databases showing HLA-E gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HLA-E gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HLA-E Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HLA-E gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HLA-E gene:
    Search GeneIP for patents involving HLA-E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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