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HLA-E Gene

protein-coding GIFtS: 59

GC06P030565

major histocompatibility complex, class I, E
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp686P19218 ^²
EA1.2 ^²
EA2.1 ^²
HLA-6.2 ^², ³
HLAE ^³
MHC ^²
OTTHUMP00000029214 ^²
QA1 ^²

Descriptions
HLA class I histocompatibility antigen, E alpha chain ^²
MHC HLA-E alpha-1 ^²
MHC HLA-E alpha-2.1 ^²
MHC class I antigen ^²
MHC class I antigen E ^³
lymphocyte antigen ^²
major histocompatibility complex, class I, E ^²

External Ids
HGNC: 4962¹
Entrez Gene: 3133²
UniProtKB: P13747³

Search outside databases for aliases for HLA-E gene

Previous GC identifers: GC06P030513 GC06P030228 GC06P030563

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HLA-E:

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer

consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored

in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of

other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons.

Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which

both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region,

and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq]

UniProtKB/Swiss-Prot: HLAE_HUMAN, P13747

Function: Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and

-G molecules

Gene Wiki entry for HLA-E

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the HLA-E gene

Entrez Gene cytogenetic band: 6p21.3 HGNC cytogenetic band: 6p21.3

HLA-E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P030565: (about GC identifiers)

Start:	30,565,250 bp from pter
End:	30,569,077 bp from pter
Size:	3,828 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000006.10 NT_007592.14 NT_113891.1 NT_113893.1

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: HLAE_HUMAN, P13747 (See protein sequence)

Recommended Name: HLA class I histocompatibility antigen, alpha chain E precursor

Size: 358 amino acids; 40157 Da

Subunit: Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin)

Subcellular location: Membrane; Single-pass type I membrane protein

Caution: The existence of allele E*0102 (PubMed:3260916) and allele E*0104 (PubMed:1977695) is

uncertain. The alleles could not be confirmed in further studies (PubMed:12445303)

PDB structures from and Proteopedia :

1KPR (3D)

1KTL (3D)

1MHE (3D)

2ESV (3D)

3BZE (3D)

3BZF (3D)

3CDG (3D)

3CII (3D)

Secondary accessions: Q30169 Q9BT83 Q9GIY7 Q9GIY8

REFSEQ proteins: NP_005507.3
Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (HLA Class I, HLA E)
	Human Recombinant Proteins from Abnova (HLA-E)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	EXP	11513152
GO:0016021	integral to membrane	IEA	--
GO:0042612	MHC class I protein complex	IEA	--

About this table

Antibodies for HLA-E:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for HLA-E
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (HLA Class I, HLA E), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (HLA-E)
	Novus Biologicals Antibodies for HLA-E

Assays for HLA-E:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P13747

ProtoNet protein and cluster: P13747

2 Blocks protein families:

IPB001039 MHC class I signature

IPB003597 Immunoglobulin C-type

UniProtKB/Swiss-Prot: HLAE_HUMAN, P13747

Similarity: Belongs to the MHC class I family

Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HLA-E)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HLA-E)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005516

Applied Biosystems Silencer® siRNAs for HLA-E

Sigma-Aldrich siRNA for HLA-E

Sigma-Aldrich shRNA for HLA-E

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for HLA-E
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005516
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005516
untagged cDNA clones in CMV expression vector (see all 2): NM_005516

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005516

UniProtKB/Swiss-Prot: HLAE_HUMAN, P13747

Function: Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and

-G molecules

Genatlas biochemistry entry for HLA-E:

HLA class Ib,44kDa,6.2kb HindIII fragment,TAP and tapasin dependent,localized at the cell

surface,harboring structural features conferring tight peptide binding specificity,correlating

with the binding of an MHC class I leader peptide (see MHC1)

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0032393	MHC class I receptor activity	TAS	3260916

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for HLA-E (Your Favorite Gene powered by Ingenuity)

Graft-versus-Host Disease Signaling
Allograft Rejection Signaling
Antigen Presentation Pathway
Autoimmune Thyroid Disease Signaling
Type I Diabetes Mellitus Signaling

GeneDecks HLA-E for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for HLA-E

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	IEA	--
GO:0006955	immune response	IEA	--
GO:0019882	antigen processing and presentation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HLA-E

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (HLA-E)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (HLA-E)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005516

Sigma-Aldrich siRNA for HLA-E

Sigma-Aldrich shRNA for HLA-E

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005516

REFSEQ mRNAs for HLA-E gene:

NM_005516.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005516

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005516
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005516
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_005516

Additional cDNA sequence:

AB209870.1 AJ293263.1 AJ293264.1 AK098434.1 AK225048.1 AK292391.1 AK296822.1 AK298695.1

AK300906.1 AK301125.1 AK314411.1 AK316327.1 AY216681.1 AY221103.1 BC002578.2 BC004297.1

BC040479.1 BX538084.1 CR610198.1 CR619908.1 CR624610.1 CR626013.1 L78455.1 L78934.1

M20022.1 M31183.1 X56841.1 X64879.1

24/79 DOTS entries (see all 79 ):

DT.91764483 DT.95245447 DT.100061168 DT.91740240 DT.91764506 DT.95245445 DT.121346331 DT.95245417

DT.95245415 DT.87005617 DT.95245421 DT.121346247 DT.121345787 DT.121346421 DT.121346111 DT.101988044

DT.91671107 DT.91831076 DT.100049205 DT.121346187 DT.121345720 DT.91954591 DT.92024656 DT.100684782

24/1003 AceView cDNA sequences (see all 1003 ):

BQ052716 BM469085 CA439069 BQ927159 AW364302 AI936021 AA588477 BQ000024

BI818829 AA367266 BM927452 AI468136 BU617600 BQ052969 BM918109 AI685484

NM_001004349 AW084174 BQ009416 BG698804 CA392815 AI298583 BG679077 AI568109

highest scoring ESTs for HLA-E:

AA866087 AK098434 AW380206 AW385691 AW388080 AW388087 AW606608 AW606611 AW797459 AW998875

Unigene Cluster for HLA-E:

Major histocompatibility complex, class I, E

Hs.650174 [show with all ESTs]

Unigene Representative Sequence: AB209870

GeneLoc Exon Structure

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HLA-E expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for HLA-E

¹ / ² / ³

7 probe-sets matching HLA-E gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32321_at²^{, 3}	U95-A	3	1.00	0.33	1.00	1.00	M16714	0.20	1.00	0.72	1
217456_x_at²^{, 3}	U133-A	7	1.00	0.61	--	--	M31183	0.80	1.00	0.91	1
200904_at²^{, 3}	U133-A	3	1.00	0.33	--	--	X56841	0.80	1.00	0.91	1
200905_x_at²^{, 3}	U133-A	9	1.00	0.28	--	--	NM_005516	0.60	1.00	0.82	1
217456_x_at²	U133Plus2	7	1.00	0.61	--	--	--	--	--	--	--
200904_at²	U133Plus2	3	1.00	0.33	--	--	--	--	--	--	--
200905_x_at²	U133Plus2	9	1.00	0.28	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACCCTTTAAC

SOURCE GeneReport for Unigene cluster: Hs.650174
Expression variation in blood from EXPOLDB for HLA-E

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for HLA-E gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	PATR-E¹	--	major histocompatibility complex, class I, E	98.76(n) 98(a)	462540 XM_518330.2 XP_518330.2
rat (Rattus norvegicus)	H2-T23¹	--	histocompatibility 2, T region locus 23	73.87(n) 64.27(a)	294228 XM_215303.4 XP_215303.3
mouse (Mus musculus)	C920025E04Rik^{1, 5}	17⁵	RIKEN cDNA C920025E04 gene^{1, 5}	77.54(n)¹ 68.62(a)¹	667803¹ XM_992574.1¹ XP_997668.1¹ AK083376⁵ AK083387⁵ (see all 6)
zebrafish (Danio rerio)	zgc:64115¹	--	zgc:64115	46.58(n) 35.09(a)	791453 NM_001110118.1 NP_001103588.1

About this table Species with no ortholog for HLA-E

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: HLAE_HUMAN, P13747

Polymorphism: The following alleles of E-1 are known: E*0101, E*0102, E*0103 and E*0104. The

sequence shown is that of E*0101

10/64 NCBI SNPs in HLA-E are shown (see all 64 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 36)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1264459^1,2	A,C,F,H	30563899(-)	`cctcaT/Cgcttc`	1	--	ng5¹		16	EU EA WA NS NA	1568
--	rs1059655^1,2	A,C,F,H	30569064(-)	`tttttT/Caattt`	1	--	ut3¹		11	EU EA WA NS MN	1296
--	rs1264457^1,2	A,C,F,O	30566043(-)	`GCGCCT/CGTCGG`	1	R/G	mis¹		12	MN NS NA EA	1338
--	rs1059510^1,2	A,C,F	30565711(-)	`CGCAGA/C/G/T TTCAC`	3	N/K N/N	mis¹ syn¹		5	MN NA	382
	rs762324^1,2	C,F,H	30563865(-)	`aattgC/Tgctcc`	1	--	ng5¹		12	EU EA WA NA	1048
--	rs17195376^1,2	C,F	30568921(+)	`GGCACG/AGGCCT`	1	--	ut3¹		2	MN	162
--	rs17195369^1,2	C,F	30568734(+)	`TCCTTC/TCCTGT`	1	--	ut3¹		2	MN	162
	rs3757335^1,2	F,H	30563511(+)	`CTGCAG/TAAGGT`	1	--	ng5¹		5	EA EU WA	1894
--	rs17875364^1,2	F	30564129(+)	`CTCCTA/GTCTCA`	1	--	ng5¹		1	MN	66
--	rs17875363^1,2	F	30564072(+)	`AGTGCA/TGTGGT`	1	--	ng5¹		1	MN	66

About this table

HapMap Linkage Disequilibrium images for HLA-E (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 143010

10/12 Novoseek disease relationships for HLA-E gene (see all 12 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
choriocarcinoma	48.93	4	15578261 (1), 19239424 (1), 11884433 (1)
spontaneous abortion	45.97	4	9894856 (3)
miscarriage recurrent	42.96	5	16514201 (3), 11270642 (2)
infection chronic	31.46	1	15751767 (1)
autoimmune diseases	6.69	2	19140831 (1), 10689118 (1)
myeloma	4.02	4	1402654 (1), 9574542 (1)
preeclampsia	0.12	1	16806485 (1)
necrosis	0.00	4	11870233 (1), 17179229 (1)
melanoma	0.00	9	16920947 (5), 12618909 (2)
cancer	0.00	4	18292941 (1), 15977644 (1), 17768067 (1), 16199130 (1)

About this table

Human Gene Mutation Database: HLA-E
Genetic Association Database: HLA-E
Human Genome Epidemiology Navigator: HLA-E (2168 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/208 PubMed articles for HLA-E gene (see all 208 ):

Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene. (PubMed id 3131426)^{2, 3, 4} Mizuno S.... Yang S.Y. (1988)
[Analysis on HLA-E polymorphism in Guangdong Han population] (PubMed id 15631661)^{1, 3, 6} Zhen Z.J....Huang S.L. (2004)
HLA-G and HLA-E polymorphisms in an indigenous African population. The ZVITAMBO Study Group. (PubMed id 11137220)^{1, 3, 6} Matte C....Roger M. (2000)
Genetic variants in nonclassical major histocompatibility complex class I human leukocyte antigen (HLA)-E and HLA-G molecules are associated with susceptibility to heterosexual acquisition of HIV-1. (PubMed id 16362895)^{1, 3, 6} Lajoie J....Roger M. (2006)
Polymorphism of human leukocyte antigen-E gene in the Japanese population with or without recurrent abortion. (PubMed id 11270642)^{1, 3, 6} Kanai T....Taketani Y. (2001)
Association of HLA-E polymorphism with severe bacterial infection and early transplant-related mortality in matched unrelated bone marrow transplantation. (PubMed id 16003246)^{1, 3, 6} Tamouza R....Charron D. (2005)
HLA-E polymorphism in patients with nasopharyngeal carcinoma. (PubMed id 15496202)^{3, 6} Hirankarn N....Mutirangura A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Distribution of human leukocyte antigens-E alleles in Thailand. (PubMed id 12929994)^{3, 6} Kimkong I....Pimtanothai N. (2003)
[Analysis on HLA-E polymorphism in Shanghai Han population] (PubMed id 11774212)^{3, 6} Zhao L....Xu L. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3133	HGNC: 4962	AceView: HLA-EandRANP1andFLJ45422	euGenes: HUgn3133	ECgene: HLA-E
H-InvDB: HLA-E

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for HLA-E
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for HLA-E:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for HLA-E-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for HLA-E		Antibodies for HLA-E
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for HLA-E		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (HLA-E)
	Antibodies (HLA-E)
	Chimera RNAi (HLA-E)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (HLA Class I, HLA E)
	Antibodies (HLA Class I, HLA E)

Search OriGene for HLA-E

Search Tocris compounds for HLA-E

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for HLA-E

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HLA-E Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for HLA-E

Summaries
for HLA-E

Genomic Location
for HLA-E

Proteins
for HLA-E

Protein Domains/
Families
for HLA-E

Gene Function
for HLA-E

Pathways & Interactions
for HLA-E

Drugs & Compounds
for HLA-E

Transcripts
for HLA-E

Expression
for HLA-E

Orthologs
for HLA-E

Paralogs
for HLA-E

SNPs/Variants
for HLA-E

Disorders & Mutations
for HLA-E

Medical News
for HLA-E

Publications
for HLA-E

Search for HLA-E

Genome Databases showing HLA-E

Other Databases showing HLA-E

Specialized Databases showing HLA-E

Licensable Technologies
for HLA-E

Services
for HLA-E

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

HLA-E Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor HLA-E

Summariesfor HLA-E

Genomic Locationfor HLA-E

Proteinsfor HLA-E

Protein Domains/Familiesfor HLA-E

Gene Functionfor HLA-E

Pathways & Interactionsfor HLA-E

Drugs & Compoundsfor HLA-E

Transcriptsfor HLA-E

Expression for HLA-E

Orthologsfor HLA-E

Paralogsfor HLA-E

SNPs/Variantsfor HLA-E

Disorders & Mutationsfor HLA-E

Medical Newsfor HLA-E

Publicationsfor HLA-E

Search for HLA-E

Genome Databases showing HLA-E

Other Databases showing HLA-E

Specialized Databases showing HLA-E

Licensable Technologiesfor HLA-E

Servicesfor HLA-E

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for HLA-E

Summaries
for HLA-E

Genomic Location
for HLA-E

Proteins
for HLA-E

Protein Domains/
Families
for HLA-E

Gene Function
for HLA-E

Pathways & Interactions
for HLA-E

Drugs & Compounds
for HLA-E

Transcripts
for HLA-E

Expression
for HLA-E

Orthologs
for HLA-E

Paralogs
for HLA-E

SNPs/Variants
for HLA-E

Disorders & Mutations
for HLA-E

Medical News
for HLA-E

Publications
for HLA-E

Licensable Technologies
for HLA-E

Services
for HLA-E