HLA-DRB6 Gene
pseudogene GIFtS: 32
GCID: GC06M032520
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major histocompatibility complex, class II, DR beta 6 (pseudogene)
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Aliases
for HLA-DRB6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
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| Major Histocompatibility Complex, Class II, DR Beta 6 (Pseudogene)1 2 |
| External Ids: | HGNC: 49541 | Entrez Gene: 31282 | Ensembl: ENSG000002293917 | UniProtKB: O779664 | | ORGUL members: | |
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| NONCODE:n384867 n384868 | |
Export aliases for HLA-DRB6 gene to outside databasesPrevious GC identifers: GC06U990052 GC06M032291 GC06Md32591 GC06Md32628 GC06M032628
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Summaries
for HLA-DRB6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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Genomic Views
for HLA-DRB6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HLA-DRB6 gene promoter:
NF-1 GR-beta Evi-1 Roaz YY1 POU2F1 CP2 POU2F1a GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for HLA-DRB6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DRB6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.3HLA-DRB6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M032520: view genomic region
(about GC identifiers)
Start:
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32,520,490 bp from pter |
End:
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32,527,799 bp from pter |
Size:
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7,310 bases |
Orientation:
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minus strand |
ORGUL member locations:
Legend (see complete legend)
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Proteins
for HLA-DRB6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/TrEMBL: O77966 (See
protein sequence)Recommended Name: MHC class II antigen Size: 34 amino acids; 4086 Da |
Protein
Domains /
Families
for HLA-DRB6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: O77966 |
Function
for HLA-DRB6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Molecular Function:
Genatlas biochemistry entry for HLA-DRB6:HLA-DR,beta 6 pseudogene,found on DR1,DR2 and DR10 haplotypes
Animal Models:
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DRB6 |
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Pathways & Interactions
for HLA-DRB6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HLA-DRB6
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Drugs & Compounds
for HLA-DRB6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HLA-DRB6
Search CenterWatch for drugs/clinical trials and news about HLA-DRB6 
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Transcripts
for HLA-DRB6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Unigene Cluster for HLA-DRB6: Major histocompatibility complex, class II, DR beta 6 (pseudogene) Hs.723344 [show with all ESTs]Unigene Representative Sequence: L765664 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000411500(uc003obm.1 uc003obn.1) ENST00000437183 ENST00000437650(uc003obo.1)
ENST00000440876
Additional cDNA sequence: AF005487.1 L76565.1 L76566.1 NR_001298.1 U33547.1 XR_159462.1 13 DOTS entries: DT.95258471 DT.92410344 DT.100650571 DT.87079048 DT.91678319 DT.92380890 DT.95227533 DT.100778733 DT.87017739 DT.92047682 DT.92382901 DT.92467727 DT.95164729 5 AceView cDNA sequences: L76566 U33547 AF005487 L76565 NR_001298
GeneLoc Exon Structure
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Expression
for HLA-DRB6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HLA-DRB6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
Genevestigator expression for HLA-DRB6
SOURCE GeneReport for Unigene cluster: Hs.723344
SABiosciences Custom PCR Arrays for HLA-DRB6
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-DRB6
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat HLA-DRB6 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DRB6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DRB6 |
Orthologs
for HLA-DRB6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for HLA-DRB6 (if available)
TreeFam Gene Tree for HLA-DRB6 (if available) |
Paralogs
for HLA-DRB6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for HLA-DRB6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for HLA-DRB6 (32520490 - 32527799 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 25 variations for HLA-DRB6
15/24 CNVs (see all 24): 7567 37840 69425 59327 69447 69420 38969 4767 4493 32791 81343 64476 3603 63175 81340
1 Indel: 69451
Locus Specific Mutation Databases (LSDB): HLA-DRB6
| SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for HLA-DRB6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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HLA-DRB6 for disorders About GeneDecksing
4  diseases for HLA-DRB6: About MalaCardssystemic lupus erythematosus lupus erythematosus gestational diabetes diabetes mellitus
Human Genome Epidemiology (HuGE) Navigator: HLA-DRB6 (2 documents)
Export disorders for HLA-DRB6 gene to outside databases
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Publications
for HLA-DRB6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for HLA-DRB6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HLA-DRB6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete cDNA sequences of the DRB6 gene from humans and chimpanzees: a possible model of a stop codon readingthrough mechanism in primates. (PubMed id 10436177)1, 3 Moreno-Pelayo M.A....Arnaiz-Villena A. (1999)
- Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system. (PubMed id 1529427)1, 3 Bodmer J.G....Sasazuki T. (1992)
- Antinuclear antibodies and HLA class II alleles in Jamaican patients with systemic lupus erythematosus. (PubMed id 17910142)1 Christian N....Barton E.N. (2007)
- Cytokine gene polymorphisms and acute human liver graft rejection. (PubMed id 12089714)1 Warle M.C....Bouma G.J. (2002)
- [Study on the gestational diabetes mellitus and histocompatibility human leukocyte antigen DRB allele polymorphism] (PubMed id 12133402)1 Song D....Jiao S. (2002)
- Transcription and weak expression of HLA-DRB6: a gene with anomalies in exon 1 and other regions. (PubMed id 9601939)1 Fernandez-Soria V.M.... Arnaiz-Villena A. (1998)
- Primate DRB6 pseudogenes: clue to the evolutionary origin of the HLA-DR2 haplotype. (PubMed id 1937579)1 Figueroa F....Klein J. (1991)
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External Searches for HLA-DRB6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing HLA-DRB6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing HLA-DRB6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HLA-DRB6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HLA-DRB6 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for HLA-DRB6 gene:
Search GeneIP for patents involving HLA-DRB6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HLA-DRB6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HLA-DRB6 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-DRB6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DRB6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-DRB6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB6 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DRB6 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DRB6 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for HLA-DRB6 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HLA-DRB6 |
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