HLA-DRB5 Gene
protein-coding GIFtS: 54
GCID: GC06M032485
|
|
major histocompatibility complex, class II, DR beta 5
| |
Aliases
for HLA-DRB5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Major Histocompatibility Complex, Class II, DR Beta 51 2 | | HLA Class II Histocompatibility Antigen, DR-5 Beta Chain2 | | DR2-Beta-21 | | HLA Class II Histocompatibility Antigen, DRB1-9 Beta Chain2 | | DR Beta-52 3 | | Human Leucocyte Antigen DRB52 | | MHC Class II Antigen DRB52 3 | | Leukocyte Antigen Class II2 | | DR-92 | | MHC Class II Antigen DRB1*92 | | DR92 | | MHC Class II HLA Beta Chain2 | | HLA-DRB2 | | MHC HLA-DR-Beta Cell Surface Glycoprotein2 | | Dw23 | | MHC HLA-DR-Beta Chain2 | | HLA Class II Histocompatibility Antigen, DR Beta 5 Chain2 | | Dw23 |
Export aliases for HLA-DRB5 gene to outside databasesPrevious GC identifers: GC06M032490 GC06Md32512 GC06M032255 GC06Md32556 GC06M032593 |
Summaries
for HLA-DRB5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HLA-DRB5:
HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of analpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system bypresenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells(APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes thetransmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all thepolymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bonemarrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 andDRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 relatedpseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DRB5_HUMAN, Q30154Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) andpresents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptidesof 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteinsthat access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenousantigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, andfor this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on theirway to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomalcompartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also asource of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In additionto APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents anantigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in theER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigenprocessing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving asmall fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DMvia direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II moleculesuntil primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transportedto the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated byHLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in theregulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis andefficient peptide loading
Gene Wiki entry for HLA-DRB5
|
Genomic Views
for HLA-DRB5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HLA-DRB5 gene promoter:
c-Fos STAT1 AP-1 STAT1beta NF-kappaB STAT1alpha NF-kappaB2 STAT3 c-Jun NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HLA-DRB5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DRB5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.3HLA-DRB5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M032485: view genomic region
(about GC identifiers)
Start:
|
32,485,120 bp from pter |
End:
|
32,498,064 bp from pter |
Size:
|
12,945 bases |
Orientation:
|
minus strand |
|
Proteins
for HLA-DRB5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DRB5_HUMAN, Q30154 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DR beta 5 chain precursor Size: 266 amino acids; 30056 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmicreticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariantchain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoessequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHCclass II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding ofantigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-passtype I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosomemembrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosomemembrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number ofintracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Caution: HLA-DRB3, HLA-DRB4 and HLA-DRB5 may represent a unique gene
4 PDB 3D structures from  and Proteopedia  for HLA-DRB5:1FV1 (3D)
1H15 (3D)
1HQR (3D)
1ZGL (3D)
Secondary accessions: B2RBV6 C7C4X3 O00157 O00283 O46700 Q29703 Q29787 Q29788 Q30126 Q30150 Q30199Q6SJR2 Q7M2H9 Q8HWS7 Q8WLR5 Q9MY54 Q9XRX6Explore the universe of human proteins at neXtProt for HLA-DRB5: NX_Q30154
Post-translational modifications:
Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to down-regulation of MHC class II (Probable)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q30154
HLA-DRB5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002116.2
ENSEMBL proteins: ENSP00000364114 Reactome Protein details: Q30154
Human Recombinant Protein Products for HLA-DRB5:
Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15): About this table
HLA-DRB5 for ontologies About GeneDecksing
HLA-DRB5 Antibody Products:
Assay Products for HLA-DRB5: |
Protein
Domains /
Families
for HLA-DRB5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HLA-DRB5 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q30154ProtoNet protein and cluster: Q30154 3 Blocks protein families: IPB000353 Class II histocompatibility antigen IPB001003 MHC Class II alpha chain IPB003597 Immunoglobulin C-type
UniProtKB/Swiss-Prot: DRB5_HUMAN, Q30154Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain |
Function
for HLA-DRB5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DRB5_HUMAN, Q30154Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) andpresents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptidesof 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteinsthat access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenousantigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, andfor this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on theirway to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomalcompartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also asource of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In additionto APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents anantigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in theER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigenprocessing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving asmall fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DMvia direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II moleculesuntil primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transportedto the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated byHLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in theregulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis andefficient peptide loading Genatlas biochemistry entry for HLA-DRB5:HLA-DR,beta 5 chain,found in DR2 haplotypes
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042605 | peptide antigen binding |
ISS | -- |
HLA-DRB5 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for HLA-DRB5:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DRB5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DRB5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HLA-DRB5 (NM_002125) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HLA-DRB5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DRB5 |
|
Pathways & Interactions
for HLA-DRB5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/29 super-pathways (see all 29) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Allograft rejection | | | 2 | Transport of MHC II:Ii complex along Golgi to TGN | | | 3 | Translocation of ZAP-70 to Immunological synapse | | | 4 | ICos-ICosL Pathway in T-Helper Cell | | | 5 | PKC-Theta Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 EMD Millipore Pathways for HLA-DRB5 (see all 6)
5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HLA-DRB5 (see all 12)
5/6  GeneGo (Thomson Reuters) Pathways for HLA-DRB5 (see all 6)
5/20 
Reactome Pathways for HLA-DRB5 (see all 20)
5/18 
Kegg Pathways (Kegg details for HLA-DRB5) (see all 18):
HLA-DRB5 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLA-DRB5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/161 Interacting proteins for HLA-DRB5 (Q301543 ENSP000003641144) via UniProtKB, MINT, STRING, and/or I2D (see all 161)About this table
Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002381 | immunoglobulin production involved in immunoglobulin mediated immune response |
ISS | -- | | GO:0002437 | inflammatory response to antigenic stimulus |
ISS | -- | | GO:0002455 | humoral immune response mediated by circulating immunoglobulin |
ISS | -- | | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
-- | -- | | GO:0006955 | immune response |
ISS | -- |
HLA-DRB5 for ontologies About GeneDecksing
|
Drugs & Compounds
for HLA-DRB5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HLA-DRB5
Search CenterWatch for drugs/clinical trials and news about HLA-DRB5 / DRB5
|
Transcripts
for HLA-DRB5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HLA-DRB5 gene: NM_002125.3 1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000374975(uc003obj.3 uc003obk.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DRB5
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DRB5
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HLA-DRB5 (NM_002125) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HLA-DRB5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DRB5 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-DRB5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HLA-DRB5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DRB5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB5 |
24/81 AceView cDNA sequences (see all 81): BF872223 BQ720779 CD366315 AI696994 BC009234 CD369995 CA447597 CB306642 BQ581218 BQ710827 CA306645 M16954 BQ549372 CD369074 M20429 BF853005 BQ008723 R86752 NM_002125 CA447257 CD366202 BU674567 AA319703 AA947943
GeneLoc Exon Structure
|
Expression
for HLA-DRB5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HLA-DRB5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HLA-DRB5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HLA-DRB5
SABiosciences Custom PCR Arrays for HLA-DRB5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-DRB5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HLA-DRB5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DRB5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB5 |
Orthologs
for HLA-DRB5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HLA-DRB5 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for HLA-DRB5 (if available)
TreeFam Gene Tree for HLA-DRB5 (if available) |
Paralogs
for HLA-DRB5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HLA-DRB5 gene
- HLA-DQA12 HLA-DPA12 HLA-DQB12 HLA-DRA2 HLA-DOB2 HLA-DRB12 HLA-DMA2 HLA-DQB22
- HLA-DOA2 ENSG000002489932 HLA-DMB2 HLA-DQA22 HLA-DPB12
18/126 SIMAP similar genes for HLA-DRB5 using alignment to 21 protein entries: DRB5_HUMAN (see all proteins)
(see all similar genes):HLA DRB4 HLA-DRB14 HLA-DRB1*1327 HLA-DRB1*1605 HLA-DR beta HLA-DRB13
DRB52 HLA-DR-beta 1 MHC class II HLA-DRB1*1315 HLA DRB1 MHC Class II HLA DRB1 DRB1*0405V3
HLA-DRBI HLA-DRB1*0402 HLA-DRB1*0407 HLA-DRB1*1301 HLA-DRB1*1302 HLA-DRB1*1402
HLA-DRB5 for paralogs About GeneDecksing
|
Genomic Variants
for HLA-DRB5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: DRB5_HUMAN, Q30154Polymorphism: The following alleles of DRB5 are known: DRB5*01:01, DRB5*01:02, DRB5*01:03, DRB5*01:04, DRB5*01:05,DRB5*01:06, DRB5*01:07, DRB5*01:09, DRB5*01:11, DRB5*01:12 DRB5*01:13, DRB5*01:14, DRB5*02:02, DRB5*02:03, DRB5*02:04,DRB5*02:05. The sequence shown is that of DRB5*01:01
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HLA-DRB5 (32485120 - 32498064 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 27 variations for HLA-DRB5
15/27 CNVs (see all 27): 7567 81336 37840 81344 69458 59327 69440 38969 4767 4493 63176 32791 81343 64476 3603
Human Gene Mutation Database (HGMD): HLA-DRB5
Locus Specific Mutation Databases (LSDB): HLA-DRB5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-DRB5 |
|
Disorders
/ Diseases
for HLA-DRB5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HLA-DRB5 for disorders About GeneDecksing
OMIM gene information: 604776
OMIM disorders: --
20/45  diseases for HLA-DRB5 (see all 45): About MalaCardshypersensitivity reaction type ii disease pityriasis rosea graft versus host disease abdominal aortic aneurysm
alveolar echinococcosis aortic aneurysm hemorrhagic fever hemorrhagic fever with renal syndrome
echinococcosis systemic lupus erythematosus lupus erythematosus gestational diabetes
multiple sclerosis ulcerative colitis kaposi's sarcoma sjogren's syndrome
rubella autoimmune thyroiditis diabetes mellitus schistosomiasis
2 diseases from the University of Copenhagen DISEASES database for HLA-DRB5:Multiple sclerosis Rheumatoid arthritis Genetic Association Database (GAD): HLA-DRB5
Human Genome Epidemiology (HuGE) Navigator: HLA-DRB5 (49 documents)
Export disorders for HLA-DRB5 gene to outside databases
|
Publications
for HLA-DRB5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HLA-DRB5 gene, integrated from 9 sources (see all 198):
(articles sorted by number of sources associating them with HLA-DRB5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. (PubMed id 18305173)1, 2 De Gassart A....Gatti E. (2008)
- HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma. (PubMed id 15902698)1, 4 Dorak M.T....Kaslow R.A. (2005)
- [The relation between the HLA-DRB1*1501 allele and the severity of multiple sclerosis in a sample of the Spanish population from the Balearic Islands: the influence exerted by sex] (PubMed id 14752708)1, 4 Zabay-Becerril J.M....Viader-Farre C. (2004)
- Roles of HLA-B, HLA-C and HLA-DPA1 incompatibilities in the outcome of unrelated stem-cell transplantation. (PubMed id 12956878)1, 4 Schaffer M....Olerup O. (2003)
- Identification of a new HLA-DRB5 allele, DRB5*0112, by routine PCR-SSP. (PubMed id 14617041)1, 2 Atkinson D.C....Briggs D.C. (2003)
- Limited diversity of HLA-DRB1*02 alleles and DRB1-DRB5 haplotype associations in four United States population groups. (PubMed id 12694574)1, 4 Baldassarre L.A....Hurley C.K. (2003)
- HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites. (PubMed id 14508706)1, 4 Rossman M.D....Monos D. (2003)
- HLA-DR and DQB1 gene polymorphism in the North-western Colombian population. (PubMed id 12144632)1, 4 Correa P.A....Anaya J.M. (2002)
- HLA class II DNA typing in a large series of European patients with systemic lupus erythematosus: correlations with clinical and autoantibody subsets. (PubMed id 11997714)1, 4 Galeazzi M....Marcolongo R. (2002)
- [Study on the gestational diabetes mellitus and histocompatibility human leukocyte antigen DRB allele polymorphism] (PubMed id 12133402)1, 4 Song D....Jiao S. (2002)
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External Searches for HLA-DRB5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing HLA-DRB5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing HLA-DRB5 gene
(According to HUGE)
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Specialized Databases showing HLA-DRB5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for HLA-DRB5 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for HLA-DRB5 gene:
Search GeneIP for patents involving HLA-DRB5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HLA-DRB5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HLA-DRB5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLA-DRB5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-DRB5 | | | OriGene Protein Over-expression Lysate for HLA-DRB5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HLA-DRB5 | | OriGene 3'-UTR Clone for HLA-DRB5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DRB5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DRB5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HLA-DRB5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-DRB5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DRB5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-DRB5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DRB5 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DRB5 |
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