HLA-DRB4 Gene
protein-coding GIFtS: 50
GCID: GC06Ml32465
|
|
major histocompatibility complex, class II, DR beta 4
(Previous symbol: HLA-DR4B)
| |
Aliases
for HLA-DRB4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Major Histocompatibility Complex, Class II, DR Beta 41 2 | | HLA Class II Histocompatibility Antigen, DR Beta 4 Chain2 | | HLA-DR4B1 2 | | Human Leucocyte Antigen DRB42 | | MHC Class II Antigen DRB42 3 | | Leukocyte Antigen2 | | DR-42 | | MHC Class II Antigen HLA-DR-Beta2 | | DR42 | | MHC Class2 Antigen2 | | DRB42 | | MHC HLA DR-Beta Chain2 | | DRB1 Transplantation Antigen2 | | |
Export aliases for HLA-DRB4 gene to outside databasesPrevious GC identifers: GC06U990051 GC06P9R0072 GC06M032556 GC06M032076 GC06M032507 GC06Me32508 GC06M032657 GC06Pe32515 GC06Mf32600 GC06Mf32601 GC06Mm32579 GC06Mo32509 |
Summaries
for HLA-DRB4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HLA-DRB4:
HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of analpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system bypresenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells(APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes thetransmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all thepolymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bonemarrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 andDRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 relatedpseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DRB4_HUMAN, P13762Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) andpresents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptidesof 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteinsthat access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenousantigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, andfor this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on theirway to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomalcompartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also asource of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In additionto APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents anantigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in theER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigenprocessing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving asmall fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DMvia direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II moleculesuntil primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transportedto the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated byHLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in theregulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis andefficient peptide loading
Gene Wiki entry for HLA-DRB4
|
Genomic Views
for HLA-DRB4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NT_167246.1 NT_167247.1 NT_167249.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for HLA-DRB4
Other transcription factors
Search SABiosciences Chromatin IP Primers for HLA-DRB4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DRB4 |
Genomic Location:
Chromosome:6
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: HSCHR6_MHC_MANNp21.32 HGNC cytogenetic band: 6p21.3 ALT_REF_LOCI_4, 6p21.3 ALT_REF_LOCI_5, 6p21.3 ALT_REF_LOCI_7GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06Ml32465: view genomic region
(about GC identifiers)
Start:
|
32,465,706 bp from pter |
End:
|
32,480,674 bp from pter |
Size:
|
14,969 bases |
Orientation:
|
minus strand |
2 alternative locations:
| Chr6-,ALT_REF_LOCI_7 32,439,895-32,454,867 | Chr6-,ALT_REF_LOCI_5 32,493,744-32,508,715 |
|
Proteins
for HLA-DRB4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DRB4_HUMAN, P13762 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DR beta 4 chain precursor Size: 266 amino acids; 29941 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmicreticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariantchain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoessequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHCclass II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding ofantigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-passtype I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosomemembrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosomemembrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number ofintracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Caution: HLA-DRB3, HLA-DRB4 and HLA-DRB5 may represent a unique gene
Secondary accessions: B0S863 O78042 P79664 Q29889 Q30163 Q6TLK6 Q860N4 Q861F3 Q8WLT9 Q9BS54Explore the universe of human proteins at neXtProt for HLA-DRB4: NX_P13762
Post-translational modifications:
Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHCclass II. When associated with ubiquitination of the alpha subunit of HLA-DR: HLA-DRA 'Lys-244', the down-regulationof MHC class II may be highly effective1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P13762
HLA-DRB4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_068818.4
ENSEMBL proteins: ENSP00000410046 Reactome Protein details: P13762
Human Recombinant Protein Products for HLA-DRB4:
Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16): About this table
HLA-DRB4 for ontologies About GeneDecksing
HLA-DRB4 Antibody Products:
Assay Products for HLA-DRB4: |
Protein
Domains /
Families
for HLA-DRB4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HLA-DRB4 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P13762ProtoNet protein and cluster: P13762 3 Blocks protein families: IPB000353 Class II histocompatibility antigen IPB001003 MHC Class II alpha chain IPB003597 Immunoglobulin C-type
UniProtKB/Swiss-Prot: DRB4_HUMAN, P13762Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain |
Function
for HLA-DRB4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DRB4_HUMAN, P13762Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) andpresents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptidesof 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteinsthat access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenousantigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, andfor this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on theirway to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomalcompartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also asource of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In additionto APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents anantigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in theER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigenprocessing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving asmall fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DMvia direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II moleculesuntil primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transportedto the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated byHLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in theregulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis andefficient peptide loading Genatlas biochemistry entry for HLA-DRB4:HLA-DR,beta 4 chain,determining DRW53
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
HLA-DRB4 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DRB4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DRB4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HLA-DRB4 (NM_021983) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HLA-DRB4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DRB4 |
|
Pathways & Interactions
for HLA-DRB4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/29 super-pathways (see all 29) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Allograft rejection | | | 2 | Transport of MHC II:Ii complex along Golgi to TGN | | | 3 | Translocation of ZAP-70 to Immunological synapse | | | 4 | ICos-ICosL Pathway in T-Helper Cell | | | 5 | PKC-Theta Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 EMD Millipore Pathways for HLA-DRB4 (see all 6)
5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HLA-DRB4 (see all 12)
5/6  GeneGo (Thomson Reuters) Pathways for HLA-DRB4 (see all 6)
5/20 
Reactome Pathways for HLA-DRB4 (see all 20)
5/18 
Kegg Pathways (Kegg details for HLA-DRB4) (see all 18):
HLA-DRB4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLA-DRB4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/49 Interacting proteins for HLA-DRB4 (P137623 ENSP000004100464) via UniProtKB, MINT, STRING, and/or I2D (see all 49)About this table
Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002381 | immunoglobulin production involved in immunoglobulin mediated immune response |
ISS | -- | | GO:0002437 | inflammatory response to antigenic stimulus |
IDA | 15795121 | | GO:0002455 | humoral immune response mediated by circulating immunoglobulin |
ISS | -- | | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
-- | -- | | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus |
IDA | 18039812 |
HLA-DRB4 for ontologies About GeneDecksing
|
Drugs & Compounds
for HLA-DRB4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HLA-DRB4
Search CenterWatch for drugs/clinical trials and news about HLA-DRB4 / DRB4
|
Transcripts
for HLA-DRB4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HLA-DRB4 gene: NM_021983.4 Unigene Cluster for HLA-DRB4: Major histocompatibility complex, class II, DR beta 4 Hs.716081 [show with all ESTs]Unigene Representative Sequence: BQ0571373 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000411959(uc011hel.2 uc011hel.2 uc011hel.2) ENST00000411959(uc011hel.2 uc011hel.2 uc011hel.2)
ENST00000411959(uc011hel.2 uc011hel.2 uc011hel.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DRB4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DRB4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HLA-DRB4 (NM_021983) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HLA-DRB4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DRB4 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-DRB4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HLA-DRB4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DRB4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB4 |
Additional cDNA sequence: FR773882.1 M14190.1 M15071.1 M16732.1 M17388.1 S48645.1 U29342.1 U47028.1 13 DOTS entries: DT.92410344 DT.100776434 DT.121314547 DT.87013458 DT.87079048 DT.91886949 DT.95227533 DT.92047682 DT.121314389 DT.121314545 DT.92380890 DT.95236254 DT.97861023
GeneLoc Exon Structure
|
Expression
for HLA-DRB4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HLA-DRB4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTTAAAAA
About this image
See HLA-DRB4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HLA-DRB4
SOURCE GeneReport for Unigene cluster: Hs.716081
SABiosciences Custom PCR Arrays for HLA-DRB4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-DRB4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HLA-DRB4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DRB4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB4 |
Orthologs
for HLA-DRB4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for HLA-DRB4 (if available)
TreeFam Gene Tree for HLA-DRB4 (if available) |
Paralogs
for HLA-DRB4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for HLA-DRB4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: DRB4_HUMAN, P13762Polymorphism: The following alleles of DRB4 are known: DRB4*01:01, DRB4*01:02, DRB4*01:03, DRB4*01:04, DRB4*01:05,DRB4*01:06 and DRB4*01:07. The sequence shown is that of DRB4*01:03
Human Gene Mutation Database (HGMD): HLA-DRB4
Locus Specific Mutation Databases (LSDB): HLA-DRB4
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for HLA-DRB4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HLA-DRB4 for disorders About GeneDecksing
20/67  diseases for HLA-DRB4 (see all 67): About MalaCardschurg-strauss syndrome guillain-barre syndrome hypersensitivity reaction type ii disease halo nevi
pityriasis rosea mixed connective tissue disease catastrophic antiphospholipid syndrome connective tissue disease
graft versus host disease abdominal aortic aneurysm aortic aneurysm type 1 diabetes mellitus
hemorrhagic fever primary biliary cirrhosis hemorrhagic fever with renal syndrome antiphospholipid syndrome
juvenile rheumatoid arthritis systemic lupus erythematosus allergic rhinitis lupus erythematosus
2 diseases from the University of Copenhagen DISEASES database for HLA-DRB4:Rheumatoid arthritis Hypersensitivity reaction type II disease 3 Novoseek disease relationships for HLA-DRB4 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hashimotos thyroiditis |
39.9 |
2 |
7744616 (1), 15055474 (1) |
| mimicry |
37.2 |
2 |
7536796 (1), 10397736 (1) |
| autoimmune diseases |
3.01 |
1 |
7536796 (1) |
Genetic Association Database (GAD): HLA-DRB4
Human Genome Epidemiology (HuGE) Navigator: HLA-DRB4 (44 documents)
Export disorders for HLA-DRB4 gene to outside databases
|
Publications
for HLA-DRB4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HLA-DRB4 gene, integrated from 9 sources (see all 219):
(articles sorted by number of sources associating them with HLA-DRB4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Specific amplification of the HLA-DRB4 gene from c-DNA. Complete coding sequence of the HLA alleles DRB4*0103101 and DRB4*01033. (PubMed id 11972878)1, 2, 9 De Pablo R.... Vilches C. (2002)
- Interactions of HLA-DRB4 and CTLA-4 genes influence thyroid function in Hashimoto's thyroiditis in Japanese population. (PubMed id 15055474)1, 4, 9 Terauchi M....Saruta T. (2003)
- HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma. (PubMed id 15902698)1, 4, 9 Dorak M.T....Kaslow R.A. (2005)
- HLA-DR and DQB1 gene polymorphism in the North-western Colombian population. (PubMed id 12144632)1, 4, 9 Correa P.A....Anaya J.M. (2002)
- MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. (PubMed id 18305173)1, 2 De Gassart A....Gatti E. (2008)
- Association between psoriasis vulgaris and MHC-DRB, -DQB genes as a contribution to disease diagnosis. (PubMed id 15908298)1, 4 Cardoso C.B....Kraemer M.H. (2005)
- HLA class II alleles in systemic sclerosis patients with anti-RNA polymerase I/III antibody: associations with subunit reactivities. (PubMed id 14677183)1, 4 Kuwana M....Kaburaki J. (2003)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- HLA class II DNA typing in a large series of European patients with systemic lupus erythematosus: correlations with clinical and autoantibody subsets. (PubMed id 11997714)1, 4 Galeazzi M....Marcolongo R. (2002)
- A male-specific increase in the HLA-DRB4 (DR53) frequency in high-risk and relapsed childhood ALL. (PubMed id 12008082)1, 4 Dorak M.T....Carin M. (2002)
|
External Searches for HLA-DRB4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HLA-DRB4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HLA-DRB4 gene
(According to HUGE)
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Specialized Databases showing HLA-DRB4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for HLA-DRB4 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for HLA-DRB4 gene:
Search GeneIP for patents involving HLA-DRB4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HLA-DRB4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | OriGene Antibodies for HLA-DRB4 | | OriGene shRNA RFP for HLA-DRB4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLA-DRB4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-DRB4 | | | OriGene Protein Over-expression Lysate for HLA-DRB4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HLA-DRB4 | | OriGene 3'-UTR Clone for HLA-DRB4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DRB4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DRB4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HLA-DRB4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HLA-DRB4 | | OriGene Custom Protein Services for HLA-DRB4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HLA-DRB4 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-DRB4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DRB4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-DRB4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DRB4 |
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 | | | | |  |  |  |  | | | | Search ThermoFisher Antibodies for HLA-DRB4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DRB4 |
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