Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLA-DRB4 Gene

protein-coding   GIFtS: 52
GCID: GC06M8U3850

Major Histocompatibility Complex, Class II, DR Beta 4


(Previous symbol: HLA-DR4B)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Major Histocompatibility Complex, Class II, DR Beta 41 2     HLA Class II Histocompatibility Antigen, DR Beta 4 Chain2
HLA-DR4B1 2     Human Leucocyte Antigen DRB42
MHC Class II Antigen DRB42 3     Leukocyte Antigen2
DR-42     MHC Class II Antigen HLA-DR-Beta2
DR42     MHC Class2 Antigen2
DRB42     MHC HLA DR-Beta Chain2
DRB1 Transplantation Antigen2     

External Ids:    HGNC: 49521   Entrez Gene: 31262   Ensembl: ENSG000002273577   UniProtKB: P137623   

Export aliases for HLA-DRB4 gene to outside databases

Previous GC identifers: GC06U990051 GC06P9R0072 GC06M032556 GC06M032076 GC06M032507 GC06Me32508 GC06M032657 GC06Pe32515 GC06Mf32600 GC06Mf32601 GC06Mm32579 GC06Mo32509 GC06Ml32465


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HLA-DRB4 Gene:
HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of
an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune
system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen
presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa
and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular
domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule
the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these
polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five
times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of
DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. (provided by
RefSeq, Jul 2008)

GeneCards Summary for HLA-DRB4 Gene: 
HLA-DRB4 (major histocompatibility complex, class II, DR beta 4) is a protein-coding gene. Diseases associated with HLA-DRB4 include hemorrhagic fever with renal syndrome, and pityriasis rosea, and among its related super-pathways are Allograft rejection and Costimulation by the CD28 family. GO annotations related to this gene include MHC class II receptor activity and peptide antigen binding.

UniProtKB/Swiss-Prot: DRB4_HUMAN, P13762
Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
(class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the
regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
efficient peptide loading

Gene Wiki entry for HLA-DRB4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NT_167246.1  NT_167247.1  NT_167249.1  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for HLA-DRB4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HLA-DRB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DRB4


Genomic Location:
Chromosome:6   

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  HSCHR6_MHC_SSTOp21.32   HGNC cytogenetic band: 6p21.3 ALT_REF_LOCI_4, 6p21.3 ALT_REF_LOCI_5, 6p21.3 ALT_REF_LOCI_7

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M8U3850:       (about GC identifiers)

Start:
3,850,430 bp from pter      End:
3,865,402 bp from pter
Size:
14,973 bases      Orientation:
unknown strand

2 alternative locations:
Chr6-,NT_167247 3,882,321-3,897,292      Chr6-,NT_167246 3,846,047-3,861,015     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DRB4_HUMAN, P13762 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen, DR beta 4 chain precursor  
Size: 266 amino acids; 29941 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
antigen presentation
Caution: HLA-DRB3, HLA-DRB4 and HLA-DRB5 may represent a unique gene
Secondary accessions: B0S863 O78042 P79664 Q29889 Q30163 Q6TLK6 Q860N4 Q861F3 Q8WLT9 Q9BS54

Explore the universe of human proteins at neXtProt for HLA-DRB4: NX_P13762

Explore proteomics data for HLA-DRB4 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of
    MHC class II. When associated with ubiquitination of the alpha subunit of HLA-DR: HLA-DRA 'Lys-244', the
    down-regulation of MHC class II may be highly effective
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P13762

  • HLA-DRB4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HLA-DRB4 Protein Expression
    REFSEQ proteins: NP_068818.4  
    ENSEMBL proteins: 
     ENSP00000410857  
    Reactome Protein details: P13762
    Human Recombinant Protein Products for HLA-DRB4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HLA-DRB4
    OriGene Protein Over-expression Lysate for HLA-DRB4
    OriGene MassSpec for HLA-DRB4 
    OriGene Custom Protein Services for HLA-DRB4
    GenScript Custom Purified and Recombinant Proteins Services for HLA-DRB4
    Novus Biologicals HLA-DRB4 Protein
    Novus Biologicals HLA-DRB4 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005765lysosomal membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS10425186
    GO:0009897external side of plasma membrane ISS--

    HLA-DRB4 for ontologies           About GeneDecksing



    HLA-DRB4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HLA-DRB4
    OriGene Custom Antibody Services for HLA-DRB4
    GenScript Custom Superior Antibodies Services for HLA-DRB4
    Novus Biologicals HLA-DRB4 Antibodies
    Abcam antibodies for HLA-DRB4
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for HLA-DRB4
    LSBio Antibodies in human, mouse, rat for HLA-DRB4 

    Assay Products for HLA-DRB4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HLA-DRB4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HLA-DRB4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HLA: Histocompatibility complex
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    5/7 InterPro protein domains (see all 7):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR000353 MHC_II_b_N
     IPR013783 Ig-like_fold
     IPR014745 MHC_II_a/b_N
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry P13762

    ProtoNet protein and cluster: P13762

    3 Blocks protein domains:
    IPB000353 Class II histocompatibility antigen
    IPB001003 MHC Class II alpha chain
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: DRB4_HUMAN, P13762
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    HLA-DRB4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DRB4_HUMAN, P13762
    Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
    and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
    peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
    of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
    hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
    via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
    As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
    contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
    endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
    MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
    epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
    tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
    an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
    of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
    degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
    (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
    the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
    affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
    membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
    Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the
    regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
    efficient peptide loading

         Genatlas biochemistry entry for HLA-DRB4:
    HLA-DR,beta 4 chain,determining DRW53

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15795121
    GO:0032395MHC class II receptor activity TAS10425186
    GO:0042605peptide antigen binding ISS--
         
    HLA-DRB4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HLA-DRB4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HLA-DRB4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HLA-DRB4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HLA-DRB4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-DRB4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HLA-DRB4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HLA-DRB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-DRB4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HLA-DRB4
    Sirion Biotech Customized adenovirus for overexpression of HLA-DRB4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HLA-DRB4 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLA-DRB4 (NM_021983)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-DRB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DRB4
    Sirion Biotech Customized lentivirus for stable overexpression of HLA-DRB4 
                         Customized lentivirus expression plasmids for stable overexpression of HLA-DRB4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HLA-DRB4
    Search LifeMap BioReagents cell lines for HLA-DRB4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DRB4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HLA-DRB4 About   (see all 29)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Allograft rejection
    Allograft rejection0.69
    Intestinal immune network for IgA production0.42
    Type I diabetes mellitus0.69
    THC Differentiation Pathway0.37
    Graft-versus-host disease0.65
    Antigen processing and presentation0.37
    Autoimmune thyroid disease0.62
    CTL Mediated Apoptosis0.36
    2CD28 co-stimulation
    Costimulation by the CD28 family0.41
    CTLA4 Signaling0.31
    3Translocation of ZAP-70 to Immunological synapse
    Translocation of ZAP-70 to Immunological synapse0.85
    PD-1 signaling0.77
    Phosphorylation of CD3 and TCR zeta chains0.85
    Generation of second messenger molecules0.64
    4ICos-ICosL Pathway in T-Helper Cell
    ICos-ICosL Pathway in T-Helper Cell0.66
    Calcium Mediated T-Cell Apoptosis0.31
    CD28 Signaling in T-Helper Cell0.66
    5Interferon Signaling
    Interferon Signaling0.61
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for HLA-DRB4 (see all 6)
        Immune response Antigen presentation by MHC class II
    G-protein signaling N-RAS regulation pathway
    Immune response IL-22 signaling pathway
    Immune response NFAT in immune response
    Immune response ICOS pathway in T-helper cell

    5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HLA-DRB4 (see all 12)
        THC Differentiation Pathway
    Calcium Mediated T-Cell Apoptosis
    IL-4 Pathway
    ICos-ICosL Pathway in T-Helper Cell
    CDC42 Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for HLA-DRB4 (see all 6)
        Immune response Antigen presentation by MHC class II
    Immune response ICOS pathway in T-helper cell
    Immune response T cell receptor signaling pathway
    Immune response IL-22 signaling pathway
    G-protein signaling N-RAS regulation pathway

    5/13        Reactome Pathways for HLA-DRB4 (see all 13)
        Interferon gamma signaling
    Costimulation by the CD28 family
    Cytokine Signaling in Immune system
    Adaptive Immune System
    Translocation of ZAP-70 to Immunological synapse


    5/22         Kegg Pathways  (Kegg details for HLA-DRB4) (see all 22):
        Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Hematopoietic cell lineage
    Intestinal immune network for IgA production


    HLA-DRB4 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLA-DRB4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/17 Interacting proteins for HLA-DRB4 (P137623 ENSP000004108574) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206308P019033I2D: score=1 
    ENSG00000226260P019033I2D: score=1 
    ENSG00000227993P019033I2D: score=1 
    ENSG00000228987P019033I2D: score=1 
    ENSG00000230726P019033I2D: score=1 
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002381immunoglobulin production involved in immunoglobulin mediated immune response ISS--
    GO:0002437inflammatory response to antigenic stimulus IDA15795121
    GO:0002455humoral immune response mediated by circulating immunoglobulin ISS--
    GO:0002862negative regulation of inflammatory response to antigenic stimulus IDA18039812
    GO:0006955immune response ISS--

    HLA-DRB4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HLA-DRB4 (DRB4)

    Search CenterWatch for drugs/clinical trials and news about HLA-DRB4 / DRB4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HLA-DRB4 gene: 
    NM_021983.4  

    Unigene Cluster for HLA-DRB4:

    Major histocompatibility complex, class II, DR beta 4
    Hs.716081  [show with all ESTs]
    Unigene Representative Sequence: BQ057137
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000411565(uc011jsg.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-DRB4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate HLA-DRB4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HLA-DRB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-DRB4
    Clone
    Products:
         
    OriGene clones in human, mouse for HLA-DRB4 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLA-DRB4 (NM_021983)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-DRB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DRB4
    Sirion Biotech Customized lentivirus for stable overexpression of HLA-DRB4 
                         Customized lentivirus expression plasmids for stable overexpression of HLA-DRB4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HLA-DRB4
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-DRB4
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HLA-DRB4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DRB4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB4

    Additional mRNA sequence: 

    FR773882.1 M14190.1 M15071.1 M16732.1 M17388.1 S48645.1 U29342.1 U47028.1 

    13 DOTS entries:

    DT.92410344  DT.100776434  DT.121314547  DT.87013458  DT.87079048  DT.91886949  DT.95227533  DT.92047682 
    DT.121314389  DT.121314545  DT.92380890  DT.95236254  DT.97861023 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HLA-DRB4 expression in normal human tissues (normalized intensities)      HLA-DRB4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTTAAAAA
    HLA-DRB4 Expression
    About this image


    HLA-DRB4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)
             Peripheral blood-derived early endothelial progenitor cells
     
     Blood (Hematopoietic System)
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Lymph (Hematopoietic System)
             LYMPH NODE   

    See HLA-DRB4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HLA-DRB4

    SOURCE GeneReport for Unigene cluster: Hs.716081
        SABiosciences Custom PCR Arrays for HLA-DRB4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HLA-DRB4
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-DRB4
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HLA-DRB4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DRB4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DRB4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for HLA-DRB4 (if available)
    TreeFam Gene Tree for HLA-DRB4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HLA-DRB4 gene
    18/153 SIMAP similar genes for HLA-DRB4 using alignment to 24 protein entries:     DRB4_HUMAN (see all proteins) (see all similar genes):
    HLA-DRB4$0101    HLA DRB4    HLA-DRB1*0402    HLA-DRB1*0407    HLA-DRB1*1301    HLA-DRB1*1302
    HLA-DRB1*1402    HLA-DRB4*0102    DRB4    HLA-DRB4* variant allele    HLA-DR4/Dw13    HLA-DR-beta 1
    HLA-DRB13    HLA-D8.2V    HLA-DR4    HLA-DRBI    HLA-DRB1*1327    HLA-DRB1*1605

    HLA-DRB4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: DRB4_HUMAN, P13762
    Polymorphism: The following alleles of DRB4 are known: DRB4*01:01, DRB4*01:02, DRB4*01:03, DRB4*01:04, DRB4*01:05,
    DRB4*01:06 and DRB4*01:07. The sequence shown is that of DRB4*01:03


    6 SNPs in HLA-DRB4 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0607804
    ----see VAR_0607802 Y H mis40--------
    VAR_0607834
    ----see VAR_0607832 G S mis40--------
    VAR_0607824
    ----see VAR_0607822 H Y mis40--------
    VAR_0607784
    ----see VAR_0607782 D G mis40--------
    VAR_0607814
    ----see VAR_0607812 G R mis40--------
    VAR_0607794
    ----see VAR_0607792 T N mis40--------

    HapMap Linkage Disequilibrium report for HLA-DRB4 (3850430 - 3865402 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HLA-DRB4: --

    Human Gene Mutation Database (HGMD): HLA-DRB4

    Locus Specific Mutation Databases (LSDB): HLA-DRB4
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HLA-DRB4
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-DRB4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    20/65 diseases for HLA-DRB4 (see all 65):    About MalaCards
    hemorrhagic fever with renal syndrome    pityriasis rosea    halo nevi    catastrophic antiphospholipid syndrome
    ascariasis    trichuriasis    churg-strauss syndrome    antiphospholipid syndrome
    mixed connective tissue disease    juvenile rheumatoid arthritis    guillain-barre syndrome    connective tissue disease
    autoimmune hepatitis    type 1 diabetes    hypersensitivity reaction type ii disease    narcolepsy
    abdominal aortic aneurysm    toxoplasmosis    psoriatic arthritis    vitiligo

    2 diseases from the University of Copenhagen DISEASES database for HLA-DRB4:
    Rheumatoid arthritis     Hypersensitivity reaction type II disease

    HLA-DRB4 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for HLA-DRB4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hashimotos thyroiditis 39.9 2 7744616 (1), 15055474 (1)
    mimicry 37.2 2 7536796 (1), 10397736 (1)
    autoimmune diseases 3.01 1 7536796 (1)

    Genetic Association Database (GAD): HLA-DRB4
    Human Genome Epidemiology (HuGE) Navigator: HLA-DRB4 (44 documents)

    Export disorders for HLA-DRB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HLA-DRB4 gene, integrated from 9 sources (see all 223):
    (articles sorted by number of sources associating them with HLA-DRB4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HLA-DRB4 as a genetic risk factor for Churg-Strauss syndrome. (PubMed id 17763415)1, 4, 9 Vaglio A....Neri T.M. (2007)
    2. Specific amplification of the HLA-DRB4 gene from c-DNA. Complete coding sequence of the HLA alleles DRB4*0103101 and DRB4*01033. (PubMed id 11972878)1, 2, 9 De Pablo R.... Vilches C. (2002)
    3. Interactions of HLA-DRB4 and CTLA-4 genes influence thyroid function in Hashimoto's thyroiditis in Japanese population. (PubMed id 15055474)1, 4, 9 Terauchi M....Saruta T. (2003)
    4. HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma. (PubMed id 15902698)1, 4, 9 Dorak M.T....Kaslow R.A. (2005)
    5. HLA-DR and DQB1 gene polymorphism in the North-western Colombian population. (PubMed id 12144632)1, 4, 9 Correa P.A....Anaya J.M. (2002)
    6. Visual hallucinations and HLA class II antigens in co rtical dementia. (PubMed id 20606439)1, 4 GA^mez-Tortosa E....CA!rdaba B. (2010)
    7. Human leukocyte antigen association in idiopathic thr ombotic thrombocytopenic purpura: evidence for an immunogenetic link. (PubMed id 19922436)1, 4 Scully M....Machin S. (2010)
    8. The impact of anti-HY responses on outcome in current and subsequent pregnancies of patients with recurrent pregnancy losses. (PubMed id 20307907)1, 4 Christiansen O.B....Nielsen H.S. (2010)
    9. Association of HY-restricting HLA class II alleles with pregnancy outcome in patients with recurrent miscarriage subsequent to a firstborn boy. (PubMed id 19223392)1, 4 Nielsen H.S....Christiansen O.B. (2009)
    10. Long-range linkage on chromosome 6p of VEGF, FKBP5, HLA and TNF alleles associated with transplant rejection. (PubMed id 19233472)1, 4 Chen Y....Hutchinson I.V. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3126 HGNC: 4952 Ensembl:ENSG00000227357 euGenes: HUgn3126 ECgene: HLA-DRB4 Kegg: 3126
    H-InvDB: HLA-DRB4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HLA-DRB4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HLA-DRB4 gene:
    Search GeneIP for patents involving HLA-DRB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HLA-DRB4   OriGene RNAi products in human, mouse, rat for HLA-DRB4  
     OriGene qPCR primer pairs and template standards for HLA-DRB4   OriGene Protein Over-expression Lysate for HLA-DRB4  
     OriGene MassSpec something-or-other for HLA-DRB4   OriGene clones in human, mouse for HLA-DRB4  
     OriGene qSTAR qPCR primer pairs in human, mouse for HLA-DRB4   OriGene Purified Protein for HLA-DRB4  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HLA-DRB4   OriGene Custom Protein Services for HLA-DRB4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HLA-DRB4
     QIAGEN SeqTarget long-range PCR primers for resequencing HLA-DRB4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DRB4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-DRB4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DRB4
     GenScript Custom Purified and Recombinant Proteins Services for HLA-DRB4 GenScript cDNA clones with any tag delivered in your preferred vector for HLA-DRB4
     GenScript Custom Assay Services for HLA-DRB4 GenScript Custom Superior Antibodies Services for HLA-DRB4
     GenScript Custom overexpressing Cell Line Services for HLA-DRB4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for HLA-DRB4
     Search Chromatin IP Primers for HLA-DRB4
     RT2 qPCR Primer Assay in human, mouse / rat HLA-DRB4
     GNC Network for HLA-DRB4
     SABiosciences PCR Arrays including human, mouse / rat HLA-DRB4
     Search Tocris compounds for HLA-DRB4 (DRB4)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HLA-DRB4 antibodies
     HLA-DRB4 proteins
     HLA-DRB4 lysates
     Antibodies for HLA-DRB4
     See all of Abcam's Antibodies, Kits and Proteins for HLA-DRB4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for HLA-DRB4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DRB4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HLA-DRB4
     Browse SwitchGear Promoter luciferase reporter plasmids for HLA-DRB4
     ThermoFisher Antibodies for HLA-DRB4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DRB4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for HLA-DRB4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HLA-DRB4
    Customized:
     lentivirus for stable overexpression of HLA-DRB4
     lentivirus expression plasmids for stable overexpression of HLA-DRB4
     adenovirus for overexpression of HLA-DRB4
     LSBio Antibodies in human, mouse, rat for HLA-DRB4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HLA-DRB4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4