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HLA-DRB2 Gene

pseudogene   GIFtS: 20
GCID: GC06M8O3972

Major Histocompatibility Complex, Class II, DR Beta 2 (Pseudogene)


(Previous symbol: HLA-DR2B)
  See HLA-DRB2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Major Histocompatibility Complex, Class II, DR Beta 2 (Pseudogene)1 2
HLA-DR2B1 2

External Ids:    HGNC: 49501   Entrez Gene: 31242   UniProtKB: O197194   UniProtKB: Q298074   UniProtKB: Q298084   
UniProtKB: Q299724   UniProtKB: Q299734   UniProtKB: Q301554   

Export aliases for HLA-DRB2 gene to outside databases

Previous GC identifers: GC06U990050 GC06M032521 GC06M032573 GC06M032078 GC06M032654 GC06Mr32610 GC06Mc32597 GC06Mj32489


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HLA-DRB2 Gene:
HLA-DRB2 (major histocompatibility complex, class II, DR beta 2 (pseudogene)) is a pseudogene. Diseases associated with HLA-DRB2 include gestational diabetes.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for HLA-DRB2
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-DRB2


Genomic Location:
Chromosome:6   

Entrez Gene cytogenetic band: 6p21.3   HGNC cytogenetic band: 6p21.3 alternate reference locus

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M8O3972:       (about GC identifiers)

Start:
3,972,666 bp from pter      End:
3,987,695 bp from pter
Size:
15,030 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/TrEMBL: O19719 (See protein sequence)
Recommended Name: HLA-DRB2 protein  
Size: 89 amino acids; 10887 Da

UniProtKB/TrEMBL: Q29807 (See protein sequence)

Recommended Name: HLA-DRB2 protein precursor  
Size: 29 amino acids; 2920 Da

UniProtKB/TrEMBL: Q29808 (See protein sequence)

Recommended Name: MHC class II antigen  
Size: 29 amino acids; 2876 Da

UniProtKB/TrEMBL: Q29972 (See protein sequence)

Recommended Name: MHC class II DR-beta  
Size: 237 amino acids; 26843 Da

UniProtKB/TrEMBL: Q29973 (See protein sequence)

Recommended Name: MHC class II DR-beta  
Size: 193 amino acids; 21585 Da

UniProtKB/TrEMBL: Q30155 (See protein sequence)

Recommended Name: HLA-DRB2 protein  
Size: 269 amino acids; 30532 Da


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
HLA: Histocompatibility complex

Selected InterPro protein domains (see all 7):
 IPR011162 MHC_I/II-like_Ag-recog
 IPR000353 MHC_II_b_N
 IPR014745 MHC_II_a/b_N
 IPR013783 Ig-like_fold
 IPR003597 Ig_C1-set

Graphical View of Domain Structure for InterPro Entry O19719
Graphical View of Domain Structure for InterPro Entry Q29807
Graphical View of Domain Structure for InterPro Entry Q29808
Graphical View of Domain Structure for InterPro Entry Q29972
Graphical View of Domain Structure for InterPro Entry Q29973
Graphical View of Domain Structure for InterPro Entry Q30155

ProtoNet protein and cluster: O19719

UniProtKB/TrEMBL: Q29972
Similarity: Contains Ig-like C1-type (immunoglobulin-like) domain

UniProtKB/TrEMBL: Q29973
Similarity: Contains Ig-like C1-type (immunoglobulin-like) domain

UniProtKB/TrEMBL: Q30155
Similarity: Contains Ig-like C1-type (immunoglobulin-like) domain


Find genes that share domains with HLA-DRB2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:
     Genatlas biochemistry entry for HLA-DRB2:
HLA-DR,like sequence (pseudogene)

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for HLA-DRB2

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for HLA-DRB2 About    
See pathways by source

SuperPathContained pathways About
1Immune response Antigen presentation by MHC class II
Immune response Antigen presentation by MHC class II0.46
Immune response IL 22 signaling pathway0.31
G protein signaling N RAS regulation pathway0.46
2Immune response NFAT in immune response
Immune response NFAT in immune response0.55
Immune response T cell receptor signaling pathway0.50
Immune response ICOS pathway in T helper cell0.55



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Interactions:

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

HLA-DRB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HLA-DRB2 gene
Selected SIMAP similar genes for HLA-DRB2 using alignment to 6 protein entries:     O19719_HUMAN (see all proteins) (see all similar genes):
HLA-DRB1*0402    HLA-DRB1*0407    HLA-DRB1*1301    HLA-DRB1*1302    HLA-DRB1*1402    HLA-DRB14
HLA-DRB4$0101    HLA DRB4    HLA-D8.2V    HLA-DRB4*0102    HLA-DR-beta 1    HLA-DR beta
HLA-DRB    HLA-DRB1*1327    HLA-DRB1*1605    DRB1*13PL    DRB1 HAG    HLA-DRB1*1324

Find genes that share paralogs with HLA-DRB2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Locus Specific Mutation Databases (LSDB): HLA-DRB2

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing HLA-DRB2
DNA2.0 Custom Variant and Variant Library Synthesis for HLA-DRB2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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1 disease for HLA-DRB2:    
About MalaCards
gestational diabetes


Find genes that share disorders with HLA-DRB2           About GenesLikeMe

Genetic Association Database (GAD): HLA-DRB2
Human Genome Epidemiology (HuGE) Navigator: HLA-DRB2 (2 documents)

Export disorders for HLA-DRB2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HLA-DRB2 gene, integrated from 10 sources (see all 13):
(articles sorted by number of sources associating them with HLA-DRB2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Modeling of PTPN22 and HLA-DRB1 susceptibility to rheumatoid arthritis. (PubMed id 18466483)1, 4 Gagnon F....Tezenas du Montcel S. (BMC Proc 2007)
  2. Characterization of an HLA-DR beta pseudogene in the DRw52 supertypic group. (PubMed id 3032786)1, 3 Rollini P....Gorski J. (Immunogenetics 1987)
  3. [Association study between HLA-DRB genes and asthmatic children]. (PubMed id 20095337)1 Zhao J....Qiu C.C. (Zhonghua Yi Xue Za Zhi 2009)
  4. Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. (PubMed id 18193213)1 Horton R....Beck S. (Immunogenetics 2008)
  5. Finishing the euchromatic sequence of the human genome. (PubMed id 15496913)1 (Nature 2004)
  6. [Study on the gestational diabetes mellitus and histocompatibility human leukocyte antigen DRB allele polymorphism]. (PubMed id 12133402)1 Song D....Jiao S. (Zhonghua Fu Chan Ke Za Zhi 2002)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  8. Initial sequencing and analysis of the human genome. (PubMed id 11237011)1 Lander E.S....Szustakowki J. (Nature 2001)
  9. A novel HLA-DRB1-DR2 allele associated with HLA mistyping. (PubMed id 8436426)1 Rosenlicht J.W.... Frey J. (Immunogenetics 1993)
  10. The evolutionary origin of the HLA-DR3 haplotype. (PubMed id 1541486)1 Vincek V....Klein J. (Immunogenetics 1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3124 HGNC: 4950 euGenes: HUgn3124 ECgene: HLA-DRB2 H-InvDB: HLA-DRB2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HLA-DRB2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HLA-DRB2 gene:
Search GeneIP for patents involving HLA-DRB2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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