HLA-DRB2 Gene
pseudogene GIFtS: 21
GCID: GC06Mj32489
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major histocompatibility complex, class II, DR beta 2 (pseudogene)
(Previous symbol: HLA-DR2B)
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Aliases
for HLA-DRB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Major Histocompatibility Complex, Class II, DR Beta 2 (Pseudogene)1 2 | | HLA-DR2B1 2 |
Export aliases for HLA-DRB2 gene to outside databasesPrevious GC identifers: GC06U990050 GC06M032521 GC06M032573 GC06M032078 GC06M032654 GC06Mr32610 GC06Mc32597 |
Summaries
for HLA-DRB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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-- |
Genomic Views
for HLA-DRB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for HLA-DRB2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HLA-DRB2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DRB2 |
Genomic Location:
Chromosome:6
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: HSCHR6_MHC_COXp21.32 HGNC cytogenetic band: 6p21.3 ALT_REF_LOCI_2, 6p21.3 ALT_REF_LOCI_6GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06Mj32489: view genomic region
(about GC identifiers)
Start:
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32,489,650 bp from pter |
End:
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32,504,679 bp from pter |
Size:
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15,030 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr6-,ALT_REF_LOCI_2 32,450,947-32,465,488 |
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Proteins
for HLA-DRB2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/TrEMBL: O19719 (See
protein sequence)Recommended Name: HLA-DRB2 protein Size: 89 amino acids; 10887 DaUniProtKB/TrEMBL: Q29807 (See
protein sequence) Recommended Name: HLA-DRB2 protein precursor Size: 29 amino acids; 2920 DaUniProtKB/TrEMBL: Q29808 (See
protein sequence) Recommended Name: MHC class II antigen Size: 29 amino acids; 2876 DaUniProtKB/TrEMBL: Q29972 (See
protein sequence) Recommended Name: MHC class II DR-beta Size: 237 amino acids; 26843 DaUniProtKB/TrEMBL: Q29973 (See
protein sequence) Recommended Name: MHC class II DR-beta Size: 193 amino acids; 21585 DaUniProtKB/TrEMBL: Q30155 (See
protein sequence) Recommended Name: HLA-DRB2 protein Size: 269 amino acids; 30532 Da |
Protein
Domains /
Families
for HLA-DRB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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HLA-DRB2 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry O19719Graphical View of Domain Structure for InterPro Entry Q29807Graphical View of Domain Structure for InterPro Entry Q29808Graphical View of Domain Structure for InterPro Entry Q29972Graphical View of Domain Structure for InterPro Entry Q29973Graphical View of Domain Structure for InterPro Entry Q30155ProtoNet protein and cluster: O19719 UniProtKB/TrEMBL: Q29972 Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/TrEMBL: Q29973 Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/TrEMBL: Q30155 Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain |
Function
for HLA-DRB2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
Genatlas biochemistry entry for HLA-DRB2:HLA-DR,like sequence (pseudogene)
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Pathways & Interactions
for HLA-DRB2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | G-protein signaling N-RAS regulation pathway | | | 2 | Immune response IL-22 signaling pathway | | | 3 | Immune response T cell receptor signaling pathway | | | 4 | Immune response_ICOS pathway in T-helper cell | | | 5 | Immune response_NFAT in immune response | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6  EMD Millipore Pathways for HLA-DRB2 (see all 6)
HLA-DRB2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HLA-DRB2
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Drugs & Compounds
for HLA-DRB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HLA-DRB2
Search CenterWatch for drugs/clinical trials and news about HLA-DRB2
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Transcripts
for HLA-DRB2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000452263
GeneLoc Exon Structure
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Expression
for HLA-DRB2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HLA-DRB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for HLA-DRB2
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat HLA-DRB2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DRB2 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB2 |
Orthologs
for HLA-DRB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for HLA-DRB2 (if available)
TreeFam Gene Tree for HLA-DRB2 (if available) |
Paralogs
for HLA-DRB2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for HLA-DRB2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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Locus Specific Mutation Databases (LSDB): HLA-DRB2
| SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for HLA-DRB2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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HLA-DRB2 for disorders About GeneDecksing
4  diseases for HLA-DRB2: About MalaCardsgestational diabetes diabetes mellitus rheumatoid arthritis arthritis
Human Genome Epidemiology (HuGE) Navigator: HLA-DRB2 (2 documents)
Export disorders for HLA-DRB2 gene to outside databases
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Publications
for HLA-DRB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for HLA-DRB2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with HLA-DRB2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of an HLA-DR beta pseudogene in the DRw52 supertypic group. (PubMed id 3032786)1, 3 Rollini P....Gorski J. (1987)
- [Association study between HLA-DRB genes and asthmati c children] (PubMed id 20095337)1 Zhao J....Qiu C.C. (2009)
- Variation analysis and gene annotation of eight MHC ha plotypes: the MHC Haplotype Project. (PubMed id 18193213)1 Horton R....Beck S. (2008)
- Modeling of PTPN22 and HLA-DRB1 susceptibility to rheumatoid arthritis. (PubMed id 18466483)1 Gagnon F....Tezenas du Montcel S. (2007)
- Finishing the euchromatic sequence of the human genome. (PubMed id 15496913)1 . (2004)
- [Study on the gestational diabetes mellitus and histocompatibility human leukocyte antigen DRB allele polymorphism] (PubMed id 12133402)1 Song D....Jiao S. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Initial sequencing and analysis of the human genome. (PubMed id 11237011)1 Lander E.S....Szustakowki J. (2001)
- A novel HLA-DRB1-DR2 allele associated with HLA mistyping. (PubMed id 8436426)1 Rosenlicht J.W.... Frey J. (1993)
- The evolutionary origin of the HLA-DR3 haplotype. (PubMed id 1541486)1 Vincek V....Klein J. (1992)
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External Searches for HLA-DRB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing HLA-DRB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing HLA-DRB2 gene
(According to HUGE)
About This Section
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Specialized Databases showing HLA-DRB2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HLA-DRB2 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for HLA-DRB2 gene:
Search GeneIP for patents involving HLA-DRB2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HLA-DRB2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HLA-DRB2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-DRB2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DRB2 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-DRB2 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DRB2 |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for HLA-DRB2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HLA-DRB2 |
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