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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLA-DRB1 Gene

protein-coding   GIFtS: 64
GCID: GC06M032546

Major Histocompatibility Complex, Class II, DR Beta 1


(Previous symbol: HLA-DR1B)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Major Histocompatibility Complex, Class II, DR Beta 11 2     DR133
HLA-DR1B1 2 5     DR143
DRw102 3     DR163
DW2.2/DR2.22 3     DR43
SS12 5     DR53
DRB12     DR73
HLA-DRB2     DR83
HLA Class II Histocompatibility Antigen, DR-1 Beta Chain2     DR93
Human Leucocyte Antigen DRB12     DRw113
Lymphocyte Antigen DRB12     DRw83
MHC Class II Antigen2     HLA-DRB23
MHC Class II HLA-DR Beta 1 Chain2     Clone P2-Beta-33
MHC Class II HLA-DR-Beta Cell Surface Glycoprotein2     MHC Class II Antigen DRB1*13
MHC Class II HLA-DRw10-Beta2     MHC Class II Antigen DRB1*103
DR-13     MHC Class II Antigen DRB1*113
DR-123     MHC Class II Antigen DRB1*123
DR-133     MHC Class II Antigen DRB1*133
DR-143     MHC Class II Antigen DRB1*143
DR-163     MHC Class II Antigen DRB1*153
DR-43     MHC Class II Antigen DRB1*163
DR-53     MHC Class II Antigen DRB1*33
DR-73     MHC Class II Antigen DRB1*43
DR-83     MHC Class II Antigen DRB1*73
DR-93     MHC Class II Antigen DRB1*83
DR13     MHC Class II Antigen DRB1*93
DR123     

External Ids:    HGNC: 49481   Entrez Gene: 31232   Ensembl: ENSG000001961267   OMIM: 1428575   UniProtKB: P042293   
UniProtKB: P019123   UniProtKB: P137603   UniProtKB: P137613   UniProtKB: Q301343   UniProtKB: Q9TQE03   
UniProtKB: Q301673   UniProtKB: P200393   UniProtKB: Q95IE33   UniProtKB: Q5Y7A73   UniProtKB: Q9GIY33   
UniProtKB: P019113   UniProtKB: Q299743   

Export aliases for HLA-DRB1 gene to outside databases

Previous GC identifers: GC06U990049 GC06Md32547 GC06M032317 GC06Md32654 GC06M032656


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HLA-DRB1 Gene:
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an
alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system
by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen
presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa.
It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular
domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule
the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1
alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney
transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is
present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4
and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. (provided by RefSeq, Jul 2008)

GeneCards Summary for HLA-DRB1 Gene: 
HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) is a protein-coding gene. Diseases associated with HLA-DRB1 include rhizomelic pseudopolyarthritis, and sarcoidosis, susceptibility l, 1, and among its related super-pathways are Allograft rejection and Costimulation by the CD28 family. GO annotations related to this gene include MHC class II receptor activity and peptide antigen binding. An important paralog of this gene is HLA-DRB5.

UniProtKB/Swiss-Prot: 2B11_HUMAN, P04229 (see all)
Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
(class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the
regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
efficient peptide loading

Gene Wiki entry for HLA-DRB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NT_113891.2  NT_167248.1  NC_000006.11  NC_018917.2  NT_007592.15  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLA-DRB1 gene promoter:
         HOXA3   AML1a   p53   CUTL1   CBF-C   YY1   CBF-B   CBF-A   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLA-DRB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HLA-DRB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DRB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

HLA-DRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-DRB1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032546:  view genomic region     (about GC identifiers)

Start:
32,546,546 bp from pter      End:
32,557,625 bp from pter
Size:
11,080 bases      Orientation:
minus strand

4 alternative locations:
Chr6-,NT_167244 3,774,424-3,787,494      Chr6-,NT_167249 3,978,426-3,993,112      Chr6-,NT_167248 3,784,600-3,797,961     
Chr6-,NT_113891.2 3,998,151-4,011,502     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: 2B11_HUMAN, P04229 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen, DRB1-1 beta chain precursor  
Size: 266 amino acids; 29914 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
antigen presentation
6/39 PDB 3D structures from and Proteopedia for HLA-DRB1 (see all 39):
1AQD (3D)        1DLH (3D)        1FYT (3D)        1HXY (3D)        1JWM (3D)        1JWS (3D)    
Secondary accessions: A4F5N0 A8K098 O62869 P13758 Q06662 Q30116 Q30117 Q5Y7E9 Q7M2H4 Q95461
Q9BCL7 Q9GIK5 Q9MXZ0 Q9MXZ5 Q9TQ91

UniProtKB/Swiss-Prot: 2B13_HUMAN, P01912 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-3 chain precursor  
Size: 266 amino acids; 30120 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
antigen presentation
1 PDB 3D structure from and Proteopedia for HLA-DRB1:
1A6A (3D)    

UniProtKB/Swiss-Prot: 2B14_HUMAN, P13760 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-4 beta chain precursor  
Size: 266 amino acids; 30112 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
antigen presentation
6/8 PDB 3D structures from and Proteopedia for HLA-DRB1 (see all 8):
1D5M (3D)        1D5X (3D)        1D5Z (3D)        1D6E (3D)        1J8H (3D)        2SEB (3D)    
Secondary accessions: O19717 O19739 P13759 Q29875 Q30145 Q9GIX9 Q9GIY4 Q9MY13 Q9XRY5

UniProtKB/Swiss-Prot: 2B17_HUMAN, P13761 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-7 beta chain precursor  
Size: 266 amino acids; 29822 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
antigen presentation
Secondary accessions: B0UYW1 O46699 O46872

UniProtKB/Swiss-Prot: 2B18_HUMAN, Q30134 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-8 beta chain precursor  
Size: 266 amino acids; 30004 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
antigen presentation
Secondary accessions: O19718 O19788 Q29968 Q30108 Q30115 Q9BCP0 Q9BCP1 Q9BCP2 Q9BD33 Q9TQ37
Q9UIM9

UniProtKB/Swiss-Prot: 2B19_HUMAN, Q9TQE0 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-9 beta chain precursor  
Size: 266 amino acids; 29826 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
antigen presentation
Secondary accessions: Q30149

UniProtKB/Swiss-Prot: 2B1A_HUMAN, Q30167 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-10 beta chain precursor  
Size: 266 amino acids; 30002 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
antigen presentation
Secondary accessions: P01914 Q9MYF5

UniProtKB/Swiss-Prot: 2B1B_HUMAN, P20039 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-11 beta chain precursor  
Size: 266 amino acids; 30160 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
antigen presentation
Secondary accessions: Q30006 Q9GIX8

UniProtKB/Swiss-Prot: 2B1C_HUMAN, Q95IE3 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-12 beta chain precursor  
Size: 266 amino acids; 29878 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
antigen presentation
Secondary accessions: A7LA26 B0LUZ6 B6VCX2 B7UDB2 O19585 Q19AF2 Q29771 Q2L9H4 Q2MZ92 Q5EER6
Q5NDB9 Q5UT58 Q5Y7G0 Q768U4 Q7YP04 Q861H8 Q95IT6 Q9BD40

UniProtKB/Swiss-Prot: 2B1D_HUMAN, Q5Y7A7 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-13 beta chain precursor  
Size: 266 amino acids; 30008 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
antigen presentation
Sequence caution: Sequence=CAB40418.1; Type=Erroneous gene model prediction;
Secondary accessions: A0MWF2 A2ICT1 A4ZXA5 A4ZXA6 A7UHG2 A7X5K7 A8YQE9 B0BK85 B3VTQ3 B5A8Y2
B5A8Y3 B5B9V6 B5QSK8 C0LAB5 O02930 O62889 O78047 P79545 Q14280 Q14QT2 Q19K86 Q1G0Z9 Q1KLJ6
Q29673 Q29720 Q29722 Q29806 Q29833 Q29874 Q29886 Q2MF40 Q2YHQ2 Q30112 Q3LA93 Q3LA94 Q3LA95
Q3LA96 Q3LA97 Q3LA98 Q3LA99 Q3LAA0 Q3LAA1 Q3LAA2 Q3MQ60 Q53IG1 Q56FP2 Q56FP3 Q58F52 Q5K3W2
Q5UBA2 Q5W3L4 Q6REE2 Q6U387 Q701T1 Q70Q85 Q768U2 Q7YP03 Q7YQ26 Q7YQA3 Q860E5 Q860H8 Q860Z3
Q861G6 Q861H0 Q861H4 Q8HWQ6 Q8WMA0 Q95389 Q95HL1 Q96HZ9 Q9BCP5 Q9BD21 Q9GIP3 Q9GJ25 Q9GJ60
Q9GJF8 Q9GJF9 Q9GJG0 Q9MY45 Q9MY56 Q9TPW3 Q9TPW9 Q9TPX4 Q9UBY1 Q9UIN0 Q9XRX1 Q9Y453

UniProtKB/Swiss-Prot: 2B1E_HUMAN, Q9GIY3 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-14 beta chain precursor  
Size: 266 amino acids; 30139 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
antigen presentation
Sequence caution: Sequence=CAB45249.1; Type=Erroneous gene model prediction;
Secondary accessions: A0N0W1 A2TGX3 A4ZY86 A5H000 A5HKN8 A7DZP9 A7X5B1 A7X5B7 A7X5E0 A7X5E6
A7X5H8 A9JPG0 B1GWE7 B2CR03 B2LVF9 B2NJ29 B2ZCY1 B3VTP8 B5B8U0 B5B9V5 B5LZ25 B6VEL9 B9VRA4
B9X248 O02876 O46793 O77969 O78210 Q0PQ39 Q155F7 Q1AP33 Q1JRP3 Q27PR6 Q27PR7 Q29734 Q29770
Q29772 Q29800 Q2A120 Q2HZE5 Q2LE76 Q2MJA6 Q2VQU1 Q307W5 Q31636 Q3LA87 Q3LA88 Q3LA89 Q3LA90
Q3LA91 Q3LA92 Q3T919 Q4PRC3 Q4PRC5 Q4VZY7 Q56FP1 Q5BM92 Q5U9W6 Q683P7 Q70GL2 Q7YNY9 Q7YQA5
Q860D8 Q860D9 Q860S0 Q861H5 Q861H7 Q8MH59 Q8MH60 Q8WLU3 Q95348 Q95HK1 Q95HL0 Q95IG2 Q9GIL5
Q9GIL6 Q9GIY0 Q9GIY1 Q9GIY2 Q9GJ56 Q9GJ57 Q9GJ58 Q9TPB6 Q9TPW1 Q9XRY4 Q9Y4H7

UniProtKB/Swiss-Prot: 2B1F_HUMAN, P01911 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-15 beta chain precursor  
Size: 266 amino acids; 29966 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
antigen presentation
Miscellaneous: The chain shown constituted about 70% of a pool of at least seven similar beta chains
3 PDB 3D structures from and Proteopedia for HLA-DRB1:
1BX2 (3D)        1YMM (3D)        2WBJ (3D)    
Secondary accessions: Q29790 Q29975 Q30142 Q30166 Q32MY7 Q56FN9 Q5Y7B0 Q5Y7B9

UniProtKB/Swiss-Prot: 2B1G_HUMAN, Q29974 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-16 beta chain precursor  
Size: 266 amino acids; 30030 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
antigen presentation
Secondary accessions: A7X5J4 O98212 Q0PGR5 Q29792 Q30120 Q30159 Q30200 Q3HUP9 Q3KTM1 Q3LA84
Q6T865 Q95383

Explore the universe of human proteins at neXtProt for HLA-DRB1: NX_Q29974

Explore proteomics data for HLA-DRB1 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of
    MHC class II (Probable)
  • View modification sites using PhosphoSitePlus (HLA-DRB4)
  • View neXtProt modification sites for NX_Q29974

  • HLA-DRB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HLA-DRB1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001230894.1  NP_002115.2  

    ENSEMBL proteins: 
     ENSP00000353099  
    Reactome Protein details: Q30167 Q5Y7A7 P04229 Q9TQE0 Q9GIY3 P01911 Q29974 P20039 Q95IE3 P01912 P13760 Q30134 P13761
    Human Recombinant Protein Products for HLA-DRB1: 
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    Novus Biologicals HLA-DRB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005765lysosomal membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS3456344
    GO:0009897external side of plasma membrane ISS--

    HLA-DRB1 for ontologies           About GeneDecksing



    HLA-DRB1 Antibody Products: 
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    Browse Antibodies at Cloud-Clone Corp. 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HLA: Histocompatibility complex
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    5/7 InterPro protein domains (see all 7):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR000353 MHC_II_b_N
     IPR013783 Ig-like_fold
     IPR014745 MHC_II_a/b_N
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry P04229
    Graphical View of Domain Structure for InterPro Entry P01912
    Graphical View of Domain Structure for InterPro Entry P13760
    Graphical View of Domain Structure for InterPro Entry P13761
    Graphical View of Domain Structure for InterPro Entry Q30134
    Graphical View of Domain Structure for InterPro Entry Q9TQE0
    Graphical View of Domain Structure for InterPro Entry Q30167
    Graphical View of Domain Structure for InterPro Entry P20039
    Graphical View of Domain Structure for InterPro Entry Q95IE3
    Graphical View of Domain Structure for InterPro Entry Q5Y7A7
    Graphical View of Domain Structure for InterPro Entry Q9GIY3
    Graphical View of Domain Structure for InterPro Entry P01911
    Graphical View of Domain Structure for InterPro Entry Q29974

    ProtoNet protein and cluster: P04229

    2 Blocks protein domains:
    IPB000353 Class II histocompatibility antigen
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: 2B11_HUMAN, P04229
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B13_HUMAN, P01912
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B14_HUMAN, P13760
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B17_HUMAN, P13761
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B18_HUMAN, Q30134
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B19_HUMAN, Q9TQE0
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1A_HUMAN, Q30167
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1B_HUMAN, P20039
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1C_HUMAN, Q95IE3
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1D_HUMAN, Q5Y7A7
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1E_HUMAN, Q9GIY3
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1F_HUMAN, P01911
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1G_HUMAN, Q29974
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    HLA-DRB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
    UniProtKB/Swiss-Prot Summary: 2B11_HUMAN, P04229 (see all)
    Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
    and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
    peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
    of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
    hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
    via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
    As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
    contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
    endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
    MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
    epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
    tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
    an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
    of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
    degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
    (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
    the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
    affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
    membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
    Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the
    regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
    efficient peptide loading

         Genatlas biochemistry entry for HLA-DRB1:
    HLA-DR,beta 1 chain,determining DR1,3,4,5 etc

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0032395MHC class II receptor activity TAS3456344
    GO:0042605peptide antigen binding ISS--
         
    HLA-DRB1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HLA-DRB1 
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    miRNA
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HLA-DRB1 About   (see all 34)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Allograft rejection
    Allograft rejection0.69
    Intestinal immune network for IgA production0.42
    Type I diabetes mellitus0.69
    THC Differentiation Pathway0.37
    Graft-versus-host disease0.65
    Antigen processing and presentation0.37
    Autoimmune thyroid disease0.62
    CTL Mediated Apoptosis0.36
    2CD28 co-stimulation
    Costimulation by the CD28 family0.41
    CTLA4 Signaling0.31
    3Translocation of ZAP-70 to Immunological synapse
    Translocation of ZAP-70 to Immunological synapse0.85
    PD-1 signaling0.77
    Phosphorylation of CD3 and TCR zeta chains0.85
    Generation of second messenger molecules0.64
    4Interferon Signaling
    Interferon Signaling0.61
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.61
    5TCR signaling
    TCR signaling0.75
    Downstream TCR signaling0.75

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for HLA-DRB1 (see all 6)
        Immune response Antigen presentation by MHC class II
    G-protein signaling N-RAS regulation pathway
    Immune response IL-22 signaling pathway
    Immune response NFAT in immune response
    Immune response ICOS pathway in T-helper cell

    5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HLA-DRB1 (see all 12)
        THC Differentiation Pathway
    Calcium Mediated T-Cell Apoptosis
    IL-4 Pathway
    ICos-ICosL Pathway in T-Helper Cell
    CDC42 Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for HLA-DRB1 (see all 6)
        Immune response Antigen presentation by MHC class II
    Immune response ICOS pathway in T-helper cell
    Immune response T cell receptor signaling pathway
    Immune response IL-22 signaling pathway
    G-protein signaling N-RAS regulation pathway

    5 BioSystems Pathways for HLA-DRB1
        Cytokines and Inflammatory Response
    TCR signaling in naive CD4+ T cells
    IL12-mediated signaling events
    CXCR4-mediated signaling events
    IL12 signaling mediated by STAT4

    5/13        Reactome Pathways for HLA-DRB1 (see all 13)
        Interferon gamma signaling
    Costimulation by the CD28 family
    Cytokine Signaling in Immune system
    Adaptive Immune System
    Translocation of ZAP-70 to Immunological synapse


    5/22         Kegg Pathways  (Kegg details for HLA-DRB1) (see all 22):
        Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Hematopoietic cell lineage
    Intestinal immune network for IgA production


    HLA-DRB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLA-DRB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/199 Interacting proteins for HLA-DRB1 (P019122 P042292 ENSP000003530994 Q299742, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 199)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235657P018922, ENSP000003885264MINT-8407259 MINT-8407185 STRING: ENSP00000388526
    ENSG00000227993P019032, ENSP000003726084MINT-24881 STRING: ENSP00000372608
    ENSG00000228987P019032, ENSP000004104434MINT-24881 STRING: ENSP00000410443
    HLA-DRAP019032, ENSP000003787864MINT-24881 STRING: ENSP00000378786
    ENSG00000206308P019032, ENSP000003727464MINT-24881 STRING: ENSP00000372746
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002381immunoglobulin production involved in immunoglobulin mediated immune response ISS--
    GO:0002437inflammatory response to antigenic stimulus ISS--
    GO:0002455humoral immune response mediated by circulating immunoglobulin ISS--
    GO:0006955immune response NAS--
    GO:0016045detection of bacterium ISS--

    HLA-DRB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HLA-DRB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HLA-DRB1 (2B1G)

    1 DrugBank Compound for HLA-DRB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glatiramer AcetateCOP-1 (see all 3)147245-92-9targetbinder15371592 11752352

    10/17 Novoseek inferred chemical compound relationships for HLA-DRB1 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dr-10 77.3 6 7780115 (1), 9550403 (1), 8754259 (1), 10626740 (1)
    dr-16 73.6 1 9243764 (1)
    dpa 1 73.1 5 8782076 (1), 8863870 (1), 17060025 (1), 10616003 (1) (see all 5)
    oligonucleotide 53.4 22 8117375 (1), 12823773 (1), 15865503 (1), 18718089 (1) (see all 20)
    gold sodium thiomalate 36 2 11093435 (1)
    valine 30.5 4 9098452 (1), 8500529 (1), 10439317 (1), 2369430 (1)
    amino acid 19.7 1 1533151 (1)
    c-peptide 4.17 1 15388265 (1)
    atp 3.36 2 12658812 (2)
    lysine 0 2 7738179 (1), 7612412 (1)

    1 PharmGKB related drug/compound annotation for HLA-DRB1 gene    About this table
    Drug/compound PharmGKB Annotation
    lapatinib

    Search CenterWatch for drugs/clinical trials and news about HLA-DRB1 / 2B1G

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HLA-DRB1 gene (2 alternative transcripts): 
    NM_001243965.1  NM_002124.3  

    Unigene Clusters for HLA-DRB1:

    Major histocompatibility complex, class II, DR beta 1
    Hs.534322  [show with all ESTs], Hs.696211  [show with all ESTs], Hs.736560  [show with all ESTs]
    Unigene Representative Sequences: AK290388, AK225690, BG484513
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000360004(uc021yvx.1 uc003obp.4 uc011dqb.1 uc011dqc.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AF004817.1 AJ580838.1 D86415.1 M15070.1 M17386.1 M25266.1 M27014.1 M59798.1 

    24/70 DOTS entries (see all 70):

    DT.92410344  DT.92028787  DT.91706875  DT.95164729  DT.92047682  DT.100776434  DT.95164752  DT.92382901 
    DT.95164731  DT.121314547  DT.87079048  DT.40115364  DT.100781798  DT.100778733  DT.100650571  DT.100766538 
    DT.121314746  DT.92380890  DT.121314807  DT.95230813  DT.97857272  DT.95164743  DT.91802323  DT.92467723 

    24/89 AceView cDNA sequences (see all 89):

    M16731 X02902 AJ245881 AJ536121 AH002891 BC024269 BV201637 AF291675 
    AJ297586 M17381 M15073 L42143 BV207240 BV207185 BV183568 BV207036 
    BV207188 BV207249 M15069 BV207215 BV200462 BV207191 U84892 BV183567 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HLA-DRB1 expression in normal human tissues (normalized intensities)      HLA-DRB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGCGCTGA
    HLA-DRB1 Expression
    About this image


    HLA-DRB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 10 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             CD19+ B Cells   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Umbilical cord-derived mesenchymal stem cells
             Cord Blood CD133- Cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 2 entries
             tonsil ; non-germinal center cells   
     
     Mesenchymal Stem Cells (Muscoskeletal System)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells
             Human Mesenchymal Stem Cells (hMSC)-1   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             lymph node ; non-germinal center cells   

    See HLA-DRB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HLA-DRB1

    SOURCE GeneReport for Unigene clusters: Hs.534322 Hs.696211 Hs.736560
        SABiosciences Expression via Pathway-Focused PCR Arrays including HLA-DRB1: 
              Multiple Sclerosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HLA-DRB1
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-DRB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HLA-DRB1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DRB1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DRB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-DRB1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia H2-Eb11 , 5 histocompatibility 2, class II antigen E beta1, 5 80.97(n)1
    75.86(a)1
      17 (17.98 cM)5
    149691  NM_010382.21  NP_034512.21 
     343058835 
    chicken
    (Gallus gallus)
    Aves BLB16
    --
    --
    51(a)
    45(a)
    many ↔ many
    many ↔ many
    16(102122-103266)
    AADN03010751.1(32-1186)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    45(a)
    1 → many
    GL343520.1(320149-320904)
    African clawed frog
    (Xenopus laevis)
    Amphibia D13688.12   -- 78.3(n)    D13688.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:zfos-2070c2.36
    mhc2dab6
    (see all 10)
    si:zfos-2070c2.3
    major histocompatibility complex class II DAB gene...
    (see all 10)
    31(a)
    31(a)
    (see all 10)
    many ↔ many
    many ↔ many
    (see all 10)
    8(37510422-37511403)
    8(37546100-37548453)


    ENSEMBL Gene Tree for HLA-DRB1 (if available)
    TreeFam Gene Tree for HLA-DRB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HLA-DRB1 gene
    HLA-DRB52  HLA-DQA12  HLA-DPA12  HLA-DQB12  HLA-DRA2  HLA-DOB2  HLA-DMA2  HLA-DQB22  
    HLA-DOA2  ENSG000002489932  HLA-DMB2  HLA-DQA22  HLA-DPB12  
    18/231 SIMAP similar genes for HLA-DRB1 using alignment to 1975 protein entries:     2B11_HUMAN (see all proteins) (see all similar genes):
    HLA DRB4    HLA-DRB1*0402    HLA-DRB1*0407    HLA-DRB1*1301    HLA-DRB1*1302    HLA-DRB1*1402
    HLA-All    HLA-A null    HLA-A*03    HLA-DRB13    HLA-DRB1*1605    HLA-B27
    HLA-DRB1*1327    HLA-DRB14    HLA-Cw3    HLA-D8.2V    HLA DRB1    HLA-DRB4$0101

    HLA-DRB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: 2B1G_HUMAN, Q29974
    Polymorphism: The following alleles of DRB1-1 are known: DRB1*01:01; DRB1*01:02; DRB1*01:03; DRB1*01:04;
    DRB1*01:05; DRB1*01:06; DRB1*01:07; DRB1*01:08; DRB1*01:09; DRB1*01:10; DRB1*01:11; DRB1*01:12; DRB1*01:13;
    DRB1*01:14; DRB1*01:15; DRB1*01:16; DRB1*01:17; DRB1*01:18; DRB1*01:19; DRB1*01:20 and DRB1*01:21. The sequence
    shown is that of DRB1*01:01
    Polymorphism: The following alleles of DRB1-3 are known: DRB1*03:01; DRB1*03:02; DRB1*03:03; DRB1*03:04;
    DRB1*03:05; DRB1*03:06; DRB1*03:07; DRB1*03:08; DRB1*03:09; DRB1*03:10; DRB1*03:11; DRB1*03:12; DRB1*03:13;
    DRB1*03:14; DRB1*03:15; DRB1*03:16; DRB1*03:17; DRB1*03:18; DRB1*03:19; DRB1*03:20; DRB1*03:21; DRB1*03:22;
    DRB1*03:23; DRB1*03:24; DRB1*03:25; DRB1*03:26; DRB1*03:27; DRB1*03:28; DRB1*03:29; DRB1*03:30; DRB1*03:31;
    DRB1*03:32; DRB1*03:33; DRB1*03:34; DRB1*03:35; DRB1*03:36; DRB1*03:37; DRB1*03:38; DRB1*03:39; DRB1*03:40 and
    DRB1*03:41. The sequence shown is that of DRB1*03:01
    Polymorphism: The following alleles of DRB1-4 are known: DRB1*04:01, DRB1*04:02, DRB1*04:03, DRB1*04:04,
    DRB1*04:05, DRB1*04:06, DRB1*04:07, DRB1*04:08, DRB1*04:09, DRB1*04:10, DRB1*04:11, DRB1*04:12, DRB1*04:13,
    DRB1*04:14, DRB1*04:15, DRB1*04:16, DRB1*04:17, DRB1*04:18, DRB1*04:19, DRB1*04:20, DRB1*04:21, DRB1*04:22,
    DRB1*04:23, DRB1*04:24, DRB1*04:25, DRB1*04:26, DRB1*04:27, DRB1*04:28, DRB1*04:29, DRB1*04:30, DRB1*04:31,
    DRB1*04:32, DRB1*04:33, DRB1*04:34, DRB1*04:35, DRB1*04:36, DRB1*04:37, DRB1*04:38, DRB1*04:39, DRB1*04:40,
    DRB1*04:41, DRB1*04:42, DRB1*04:43, DRB1*04:44, DRB1*04:45, DRB1*04:46, DRB1*04:47, DRB1*04:48, DRB1*04:49,
    DRB1*04:50, DRB1*04:51, DRB1*04:52, DRB1*04:53, DRB1*04:54, DRB1*04:55, DRB1*04:56, DRB1*04:57, DRB1*04:58,
    DRB1*04:59, DRB1*04:60, DRB1*04:61, DRB1*04:62, DRB1*04:63, DRB1*04:64, DRB1*04:65, DRB1*04:66, DRB1*04:67,
    DRB1*04:68, DRB1*04:69, DRB1*04:70, DRB1*04:71, DRB1*04:72, DRB1*04:73, DRB1*04:74, DRB1*04:75, DRB1*04:76,
    DRB1*04:77 and DRB1*04:78. The sequence shown is that of DRB1*04:01
    Polymorphism: The following alleles of DRB1-7 are known: DRB1*07:01, DRB1*07:03, DRB1*07:04, DRB1*07:05,
    DRB1*07:06, DRB1*07:07, DRB1*07:08, DRB1*07:09, DRB1*07:11, DRB1*07:12, DRB1*07:13, DRB1*07:14, DRB1*07:15,
    DRB1*07:16 and DRB1*07:17. The sequence shown is that of DRB1*07:01
    Polymorphism: Allele DRB1*07:01 is associated with persistent hepatitis C virus (HCV) infections [MIM:609532]
    Polymorphism: The following alleles of DRB1-8 are known: DRB1*08:01 (Dw8.1), DRB1*08:02 (Dw8.2; DRB1L), DRB1*08:03
    (Dw8.3); DRB1*08:04; DRB1*08:05, DRB1*08:06, DRB1*08:07, DRB1*08:08, DRB1*08:09, DRB1*08:10, DRB1*08:11,
    DRB1*08:12, DRB1*08:13, DRB1*08:14, DRB1*08:15, DRB1*08:16, DRB1*08:17, DRB1*08:18, DRB1*08:19, DRB1*08:20,
    DRB1*08:21, DRB1*08:22, DRB1*08:23, DRB1*08:24, DRB1*08:25, DRB1*08:26, DRB1*08:27, DRB1*08:28, DRB1*08:29,
    DRB1*08:30, DRB1*08:31, DRB1*08:32, DRB1*08:33, DRB1*08:34, DRB1*08:35 and DRB1*08:36. The sequence shown is that
    of DRB1*08:01
    Polymorphism: The following alleles of DRB1-9 are known: DRB1*09:01, DRB1*09:02, DRB1*09:03, DRB1*09:04,
    DRB1*09:05, DRB1*09:06, DRB1*09:07 and DRB1*09:08. The sequence shown is that of DRB1*09:01
    Polymorphism: The following alleles of DRB1-10 are known: DRB1*10:01; DRB1*10:02 and DRB1*10:03. The sequence
    shown is that of DRB1*10:01
    Polymorphism: The following alleles of DRB1-11 are known: DRB1*11:01, DRB1*11:03, DRB1*11:04, DRB1*11:05,
    DRB1*11:06, DRB1*11:07, DRB1*11:08, DRB1*11:09, DRB1*11:10, DRB1*11:11, DRB1*11:12, DRB1*11:13, DRB1*11:14,
    DRB1*11:15, DRB1*11:16, DRB1*11:17, DRB1*11:18, DRB1*11:19, DRB1*11:20, DRB1*11:21, DRB1*11:22, DRB1*11:23,
    DRB1*11:24, DRB1*11:25, DRB1*11:26, DRB1*11:27, DRB1*11:28, DRB1*11:29, DRB1*11:30, DRB1*11:31, DRB1*11:32,
    DRB1*11:33, DRB1*11:34, DRB1*11:35, DRB1*11:36, DRB1*11:37, DRB1*11:38, DRB1*11:39, DRB1*11:40, DRB1*11:41,
    DRB1*11:42, DRB1*11:43, DRB1*11:44, DRB1*11:45, DRB1*11:46, DRB1*11:47, DRB1*11:48, DRB1*11:49, DRB1*11:50,
    DRB1*11:51, DRB1*11:52, DRB1*11:53, DRB1*11:54, DRB1*11:55, DRB1*11:56, DRB1*11:57, DRB1*11:58, DRB1*11:59,
    DRB1*11:60, DRB1*11:61, DRB1*11:62, DRB1*11:63, DRB1*11:64, DRB1*11:65, DRB1*11:66, DRB1*11:67, DRB1*11:68,
    DRB1*11:69, DRB1*11:70 and DRB1*11:72. The sequence shown is that of DRB1*11:01
    Polymorphism: Allele DRB1*11:01 is associated with self-limiting hepatitis C virus (HCV) infections [MIM:609532]
    Polymorphism: The following alleles of DRB1-12 are known: DRB1*12:01, DRB1*12:02, DRB1*12:03, DRB1*12:04,
    DRB1*12:05, DRB1*12:06, DRB1*12:07, DRB1*12:08, DRB1*12:09, DRB1*12:10, DRB1*12:11, DRB1*12:12, DRB1*12:13,
    DRB1*12:14, DRB1*12:15, DRB1*12:16, DRB1*12:17, DRB1*12:18 and DRB1*12:19. The sequence shown is that of
    DRB1*12:01
    Polymorphism: The following alleles of DRB1-13 are known: DRB1*13:01, DRB1*13:02, DRB1*13:03, DRB1*13:04,
    DRB1*13:05, DRB1*13:06, DRB1*13:07, DRB1*13:08, DRB1*13:09, DRB1*13:10, DRB1*13:11, DRB1*13:12, DRB1*13:13,
    DRB1*13:14, DRB1*13:15, DRB1*13:16, DRB1*13:17, DRB1*13:18, DRB1*13:19, DRB1*13:20, DRB1*13:21, DRB1*13:22,
    DRB1*13:23, DRB1*13:24, DRB1*13:25, DRB1*13:26, DRB1*13:27, DRB1*13:28, DRB1*13:29, DRB1*13:30, DRB1*13:31,
    DRB1*13:32, DRB1*13:33, DRB1*13:34, DRB1*13:35, DRB1*13:36, DRB1*13:37, DRB1*13:38, DRB1*13:39, DRB1*13:40,
    DRB1*13:41, DRB1*13:42, DRB1*13:43, DRB1*13:44, DRB1*13:45, DRB1*13:46, DRB1*13:47, DRB1*13:48, DRB1*13:49,
    DRB1*13:50, DRB1*13:51, DRB1*13:52, DRB1*13:53, DRB1*13:54, DRB1*13:55, DRB1*13:56, DRB1*13:57, DRB1*13:58,
    DRB1*13:59, DRB1*13:60, DRB1*13:61, DRB1*13:62, DRB1*13:63, DRB1*13:64, DRB1*13:65, DRB1*13:66, DRB1*13:67,
    DRB1*13:68, DRB1*13:69, DRB1*13:70, DRB1*13:71, DRB1*13:72, DRB1*13:73, DRB1*13:74, DRB1*13:75, DRB1*13:76,
    DRB1*13:77, DRB1*13:78, DRB1*13:79, DRB1*13:80, DRB1*13:81, DRB1*13:82, DRB1*13:83, DRB1*13:84, DRB1*13:85,
    DRB1*13:86, DRB1*13:87 and DRB1*13:88. The sequence shown is that of DRB1*13:01
    Polymorphism: The following alleles of DRB1-14 are known: DRB1*14:01, DRB1*14:02, DRB1*14:03, DRB1*14:04,
    DRB1*14:05, DRB1*14:06, DRB1*14:07, DRB1*14:08, DRB1*14:09, DRB1*14:10, DRB1*14:11, DRB1*14:12, DRB1*14:13,
    DRB1*14:14, DRB1*14:15, DRB1*14:16, DRB1*14:17, DRB1*14:18, DRB1*14:19, DRB1*14:20, DRB1*14:21, DRB1*14:22,
    DRB1*14:23, DRB1*14:24, DRB1*14:25, DRB1*14:26, DRB1*14:27, DRB1*14:28, DRB1*14:29, DRB1*14:30, DRB1*14:31,
    DRB1*14:32, DRB1*14:33, DRB1*14:34, DRB1*14:35, DRB1*14:36, DRB1*14:37, DRB1*14:38, DRB1*14:39, DRB1*14:40,
    DRB1*14:41, DRB1*14:42, DRB1*14:43, DRB1*14:44, DRB1*14:45, DRB1*14:46, DRB1*14:47, DRB1*14:48, DRB1*14:49,
    DRB1*14:50, DRB1*14:51, DRB1*14:52, DRB1*14:53, DRB1*14:54, DRB1*14:55, DRB1*14:56, DRB1*14:57, DRB1*14:58,
    DRB1*14:59, DRB1*14:60, DRB1*14:61, DRB1*14:62, DRB1*14:63, DRB1*14:64, DRB1*14:65, DRB1*14:67, DRB1*14:68,
    DRB1*14:69, DRB1*14:70, DRB1*14:71, DRB1*14:72, DRB1*14:73, DRB1*14:74, DRB1*14:75, DRB1*14:76, DRB1*14:77,
    DRB1*14:78, DRB1*14:79, DRB1*14:80, DRB1*14:81, DRB1*14:82, DRB1*14:83, DRB1*14:84 and DRB1*14:85. The sequence
    shown is that of DRB1*14:01
    Polymorphism: The following alleles of DRB1-15 are known: DRB1*15:01, DRB1*15:02, DRB1*15:03, DRB1*15:04,
    DRB1*15:05, DRB1*15:06, DRB1*15:07, DRB1*15:08, DRB1*15:09, DRB1*15:10, DRB1*15:11, DRB1*15:12, DRB1*15:13,
    DRB1*15:14, DRB1*15:15, DRB1*15:16, DRB1*15:18, DRB1*15:19, DRB1*15:20, DRB1*15:21, DRB1*15:22, DRB1*15:23,
    DRB1*15:24, DRB1*15:25, DRB1*15:26, DRB1*15:27, DRB1*15:28, DRB1*15:29, DRB1*15:30, DRB1*15:31 and DRB1*15:32.
    The sequence shown is that of DRB1*15:01
    Polymorphism: The following alleles of DRB1-16 are known: DRB1*16:01; DRB1*16:02; DRB1*16:03; DRB1*16:04;
    DRB1*16:05; DRB1*16:07; DRB1*16:08; DRB1*16:09; DRB1*16:10; DRB1*16:11 and DRB1*16:12. The sequence shown is that
    of DRB1*16:02


    1470 SNPs in HLA-DRB1 are shown (see top 10)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0629504
    ----see VAR_0629502 V A mis40--------
    VAR_0629014
    ----see VAR_0629012 T N mis40--------
    VAR_0629134
    ----see VAR_0629132 S G mis40--------
    VAR_0565414
    ----see VAR_0565412 T R mis40--------
    VAR_0333804
    ----see VAR_0333802 R Q mis40--------
    VAR_0503674
    ----see VAR_0503672 G S mis40--------
    VAR_0628374
    ----see VAR_0628372 T A mis40--------
    VAR_0628444
    ----see VAR_0628442 Y F mis40--------
    VAR_0565434
    ----see VAR_0565432 V M mis40--------
    VAR_0333834
    ----see VAR_0333832 Y S mis40--------
    VAR_0629434
    ----see VAR_0629432 A G mis40--------
    VAR_0166744
    ----see VAR_0166742 L I mis40--------
    VAR_0628784
    ----see VAR_0628782 N F mis40--------
    VAR_0629464
    ----see VAR_0629462 E R mis40--------
    VAR_0628894
    ----see VAR_0628892 D A mis40--------
    VAR_0628834
    ----see VAR_0628832 F Y mis40--------
    VAR_0503694
    ----see VAR_0503692 V M mis40--------
    VAR_0629244
    ----see VAR_0629242 V L mis40--------
    VAR_0628354
    ----see VAR_0628352 V G mis40--------
    VAR_0333874
    ----see VAR_0333872 A E mis40--------
    VAR_0166764
    ----see VAR_0166762 K E mis40--------
    VAR_0629384
    ----see VAR_0629382 R D mis40--------
    VAR_0565454
    ----see VAR_0565452 V M mis40--------
    VAR_0629054
    ----see VAR_0629052 V D mis40--------
    VAR_0565334
    ----see VAR_0565332 V M mis40--------
    VAR_0629364
    ----see VAR_0629362 L I mis40--------
    VAR_0629344
    ----see VAR_0629342 H S mis40--------
    VAR_0629524
    ----see VAR_0629522 V M mis40--------
    VAR_0629494
    ----see VAR_0629492 H Y mis40--------
    VAR_0629284
    ----see VAR_0629282 A D mis40--------
    VAR_0628874
    ----see VAR_0628872 D S mis40--------
    VAR_0628984
    ----see VAR_0628982 E A mis40--------
    VAR_0333934
    ----see VAR_0333932 R Q mis40--------
    VAR_0629324
    ----see VAR_0629322 A E mis40--------
    VAR_0629114
    ----see VAR_0629112 T K mis40--------
    VAR_0167154
    ----see VAR_0167152 G V mis40--------
    VAR_0629164
    ----see VAR_0629162 R Q mis40--------
    VAR_0333774
    ----see VAR_0333772 T A mis40--------
    VAR_0333954
    ----see VAR_0333952 V M mis40--------
    VAR_0628474
    ----see VAR_0628472 R A mis40--------
    VAR_0628334
    ----see VAR_0628332 E G mis40--------
    VAR_0503734
    ----see VAR_0503732 G S mis40--------
    VAR_0628194
    ----see VAR_0628192 A T mis40--------
    VAR_0166774
    ----see VAR_0166772 K R mis40--------
    VAR_0565374
    ----see VAR_0565372 K R mis40--------
    VAR_0628954
    ----see VAR_0628952 D Q mis40--------
    VAR_0629084
    ----see VAR_0629082 S R mis40--------
    VAR_0628414
    ----see VAR_0628412 E K mis40--------
    VAR_0628814
    ----see VAR_0628812 N I mis40--------
    VAR_0628714
    ----see VAR_0628712 H Q mis40--------
    VAR_0628484
    ----see VAR_0628482 A L mis40--------
    VAR_0503744
    ----see VAR_0503742 T A mis40--------
    VAR_0628964
    ----see VAR_0628962 E R mis40--------
    VAR_0565274
    ----see VAR_0565272 K R mis40--------
    VAR_0628934
    ----see VAR_0628932 I L mis40--------
    VAR_0628464
    ----see VAR_0628462 F L mis40--------
    VAR_0565384
    ----see VAR_0565382 V M mis40--------
    VAR_0503654
    ----see VAR_0503652 F Y mis40--------
    VAR_0629194
    ----see VAR_0629192 D E mis40--------
    VAR_0628734
    ----see VAR_0628732 F Y mis40--------
    VAR_0628694
    ----see VAR_0628692 S G mis40--------
    VAR_0628284
    ----see VAR_0628282 A E mis40--------
    VAR_0628724
    ----see VAR_0628722 R L mis40--------
    VAR_0628254
    ----see VAR_0628252 L V mis40--------
    VAR_0381624
    ----see VAR_0381622 Y H mis40--------
    VAR_0629204
    ----see VAR_0629202 Y H mis40--------
    VAR_0628234
    ----see VAR_0628232 L F mis40--------
    VAR_0333924
    ----see VAR_0333922 Q H mis40--------
    VAR_0629264
    ----see VAR_0629262 Y F mis40--------
    VAR_0629024
    ----see VAR_0629022 G R mis40--------
    VAR_0333904
    ----see VAR_0333902 A T mis40--------
    VAR_0628804
    ----see VAR_0628802 N D mis40--------
    VAR_0628674
    ----see VAR_0628672 S L mis40--------
    VAR_0333794
    ----see VAR_0333792 R K mis40--------
    VAR_0628824
    ----see VAR_0628822 V L mis40--------
    VAR_0628854
    ----see VAR_0628852 R W mis40--------
    VAR_0629484
    ----see VAR_0629482 T A mis40--------
    VAR_0629064
    ----see VAR_0629062 Y Q mis40--------
    VAR_0628304
    ----see VAR_0628302 S Y mis40--------
    VAR_0503704
    ----see VAR_0503702 T R mis40--------
    VAR_0629094
    ----see VAR_0629092 S V mis40--------
    VAR_0628424
    ----see VAR_0628422 L P mis40--------
    VAR_0167174
    ----see VAR_0167172 R E mis40--------
    VAR_0333894
    ----see VAR_0333892 G D mis40--------
    VAR_0628214
    ----see VAR_0628212 V I mis40--------
    VAR_0565424
    ----see VAR_0565422 F Y mis40--------
    VAR_0628454
    ----see VAR_0628452 F I mis40--------
    VAR_0629424
    ----see VAR_0629422 A S mis40--------
    VAR_0629124
    ----see VAR_0629122 S H mis40--------
    VAR_0333854
    ----see VAR_0333852 Q H mis40--------
    VAR_0628764
    ----see VAR_0628762 H Y mis40--------
    VAR_0167414
    ----see VAR_0167412 G R mis40--------
    VAR_0166844
    ----see VAR_0166842 F I mis40--------
    VAR_0628364
    ----see VAR_0628362 H E mis40--------
    VAR_0628744
    ----see VAR_0628742 L Q mis40--------
    VAR_0629144
    ----see VAR_0629142 H Y mis40--------
    VAR_0628344
    ----see VAR_0628342 A V mis40--------
    VAR_0565314
    ----see VAR_0565312 T R mis40--------
    VAR_0629444
    ----see VAR_0629442 E A mis40--------
    VAR_0629174
    ----see VAR_0629172 F Y mis40--------
    VAR_0167134
    ----see VAR_0167132 T N mis40--------
    VAR_0503664
    ----see VAR_0503662 T N mis40--------
    VAR_0167104
    ----see VAR_0167102 L I mis40--------
    VAR_0565304
    ----see VAR_0565302 V M mis40--------
    VAR_0628324
    ----see VAR_0628322 I L mis40--------
    VAR_0629374
    ----see VAR_0629372 R Q mis40--------
    VAR_0381634
    ----see VAR_0381632 I F mis40--------
    VAR_0166754
    ----see VAR_0166752 Q D mis40--------
    VAR_0629044
    ----see VAR_0629042 V G mis40--------
    VAR_0629234
    ----see VAR_0629232 F N mis40--------
    VAR_0166734
    ----see VAR_0166732 D S mis40--------
    VAR_0629454
    ----see VAR_0629452 E L mis40--------
    VAR_0167424
    ----see VAR_0167422 R A mis40--------
    VAR_0166784
    ----see VAR_0166782 A E mis40--------
    VAR_0628794
    ----see VAR_0628792 N S mis40--------
    VAR_0629314
    ----see VAR_0629312 A V mis40--------
    VAR_0629074
    ----see VAR_0629072 Y L mis40--------
    VAR_0565294
    ----see VAR_0565292 K R mis40--------
    VAR_0628204
    ----see VAR_0628202 V A mis40--------
    VAR_0565364
    ----see VAR_0565362 T R mis40--------
    VAR_0333814
    ----see VAR_0333812 S Y mis40--------
    VAR_0503684
    ----see VAR_0503682 A T mis40--------
    VAR_0628944
    ----see VAR_0628942 L R mis40--------
    VAR_0503724
    ----see VAR_0503722 N T mis40--------
    VAR_0167124
    ----see VAR_0167122 R E mis40--------
    VAR_0628494
    ----see VAR_0628492 T R mis40--------
    VAR_0629004
    ----see VAR_0629002 A E mis40--------
    VAR_0629274
    ----see VAR_0629272 T R mis40--------
    VAR_0167404
    ----see VAR_0167402 Q E mis40--------
    VAR_0333944
    ----see VAR_0333942 T I mis40--------
    VAR_0628974
    ----see VAR_0628972 E K mis40--------
    VAR_0333784
    ----see VAR_0333782 A S mis40--------
    VAR_0565394
    ----see VAR_0565392 T R mis40--------
    VAR_0629404
    ----see VAR_0629402 R E mis40--------
    VAR_0628884
    ----see VAR_0628882 D V mis40--------
    VAR_0629394
    ----see VAR_0629392 R K mis40--------
    VAR_0629104
    ----see VAR_0629102 S P mis40--------
    VAR_0628904
    ----see VAR_0628902 Y S mis40--------
    VAR_0628704
    ----see VAR_0628702 H Y mis40--------
    VAR_0565344
    ----see VAR_0565342 T R mis40--------
    VAR_0166804
    ----see VAR_0166802 R S mis40--------
    VAR_0628404
    ----see VAR_0628402 R K mis40--------
    VAR_0629214
    ----see VAR_0629212 H Y mis40--------
    VAR_0628294
    ----see VAR_0628292 E Q mis40--------
    VAR_0628864
    ----see VAR_0628862 V L mis40--------
    VAR_0629334
    ----see VAR_0629332 H Y mis40--------
    VAR_0629184
    ----see VAR_0629182 L M mis40--------
    VAR_0503714
    ----see VAR_0503712 Y F mis40--------
    VAR_0628184
    ----see VAR_0628182 R K mis40--------
    VAR_0628384
    ----see VAR_0628382 H Q mis40--------
    VAR_0565404
    ----see VAR_0565402 V M mis40--------
    VAR_0629304
    ----see VAR_0629302 A T mis40--------
    VAR_0503644
    ----see VAR_0503642 K R mis40--------
    VAR_0628924
    ----see VAR_0628922 I F mis40--------
    VAR_0565284
    ----see VAR_0565282 T R mis40--------
    VAR_0629414
    ----see VAR_0629412 R A mis40--------
    VAR_0628774
    ----see VAR_0628772 N Y mis40--------
    VAR_0565324
    ----see VAR_0565322 K R mis40--------
    VAR_0628844
    ----see VAR_0628842 R L mis40--------
    VAR_0629224
    ----see VAR_0629222 F Y mis40--------
    VAR_0628314
    ----see VAR_0628312 I F mis40--------
    VAR_0629534
    ----see VAR_0629532 Y H mis40--------
    VAR_0628264
    ----see VAR_0628262 F L mis40--------
    VAR_0166834
    ----see VAR_0166832 S D mis40--------
    VAR_0629474
    ----see VAR_0629472 T N mis40--------
    VAR_0628434
    ----see VAR_0628432 S N mis40--------
    VAR_0167184
    ----see VAR_0167182 G V mis40--------
    VAR_0166854
    ----see VAR_0166852 G V mis40--------
    VAR_0333914
    ----see VAR_0333912 V M mis40--------
    VAR_0628914
    ----see VAR_0628912 Y H mis40--------
    VAR_0628664
    ----see VAR_0628662 Y L mis40--------
    VAR_0628394
    ----see VAR_0628392 R T mis40--------
    VAR_0628274
    ----see VAR_0628272 V D mis40--------
    VAR_0167114
    ----see VAR_0167112 Q D mis40--------
    VAR_0166824
    ----see VAR_0166822 V Y mis40--------
    VAR_0629254
    ----see VAR_0629252 G R mis40--------
    VAR_0333864
    ----see VAR_0333862 A G mis40--------
    VAR_0629514
    ----see VAR_0629512 V G mis40--------
    VAR_0167164
    ----see VAR_0167162 Q E mis40--------
    VAR_0628754
    ----see VAR_0628752 D E mis40--------
    VAR_0166814
    ----see VAR_0166812 T N mis40--------
    VAR_0166794
    ----see VAR_0166792 G V mis40--------
    VAR_0629034
    ----see VAR_0629032 V A mis40--------
    VAR_0333844
    ----see VAR_0333842 Q E mis40--------
    VAR_0628994
    ----see VAR_0628992 A L mis40--------
    VAR_0629294
    ----see VAR_0629292 A S mis40--------
    VAR_0628224
    ----see VAR_0628222 R L mis40--------
    VAR_0167144
    ----see VAR_0167142 V A mis40--------
    VAR_0565354
    ----see VAR_0565352 V M mis40--------
    VAR_0381644
    ----see VAR_0381642 V G mis40--------
    VAR_0628244
    ----see VAR_0628242 L F mis40--------
    VAR_0628684
    ----see VAR_0628682 T K mis40--------
    VAR_0629154
    ----see VAR_0629152 H Q mis40--------
    VAR_0333884
    ----see VAR_0333882 Y H mis40--------
    VAR_0629354
    ----see VAR_0629352 L F mis40--------
    VAR_0333824
    ----see VAR_0333822 Y F mis40--------
    rs719457571,2
    C--32546054(+) CTCTC-/AGAT  
            
    AGAAC
    3 -- ds50010--------
    rs412871501,2
    C--32546056(+) CTCAGA/GTAGAA 3 -- ds50014Minor allele frequency- G:0.30WA NA EA 360
    rs343302471,2
    C--32546057(+) TCAGA-/T/TAGA
            
    GAACA
    1 -- ds50010--------
    rs92696481,2
    C--32546060(+) GATAGC/AACATA 3 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs92696491,2
    C--32546067(+) CATAAT/CGGAGA 3 -- ds50011Minor allele frequency- C:0.00NA 2
    rs92696501,2
    C--32546068(+) ATAACG/AGAGAA 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs339255761,2
    C--32546073(+) GAGAA-/CTCC  
            
    CTCTC
    1 -- ds50010--------
    rs92696511,2
    C,F--32546074(+) GAGAAC/TTCTCC 1 -- ds50012Minor allele frequency- T:0.38NA MN 8
    rs92696521,2
    C,F--32546075(+) AGAACC/TCTCCA 1 -- ds50011Minor allele frequency- T:0.50MN 6
    rs356893431,2
    C--32546079(+) CTCTCC/TATCTT 1 -- ds50010--------
    rs92696531,2
    C,F--32546080(+) TCTCCG/ATCTTC 3 -- ds50012Minor allele frequency- A:0.43MN CSA 7
    rs92696541,2
    C,F--32546091(+) TAAATG/TTGTCT 3 -- ds50018Minor allele frequency- T:0.38NA MN WA CSA EA 372
    rs677618311,2
    C--32546099(+) TCTTT-/CTCT  
            
    GAAAT
    1 -- ds50011Minor allele frequency- CTCT:0.00NA 2
    rs47135361,2
    C,F,H--32546115(+) GTACAA/GGTCCT 1 -- ds50012Minor allele frequency- G:0.12NA EA 240
    rs353908361,2
    --32546124(+) CTTTGA/GTAACA 1 -- ds50010--------
    rs342277961,2
    C--32546128(+) GATAAC/TACTGT 1 -- ds50010--------
    rs92696551,2
    C,F--32546132(+) ACACTA/GTATTA 3 -- ds50019Minor allele frequency- G:0.31MN NA WA CSA EA 373
    rs715404261,2
    C--32546140(+) TTATTT/GAAGTC 3 -- ds50012Minor allele frequency- G:0.00NA 4
    rs94691641,2
    C,F--32546147(+) AGTCTC/TTGGAG 1 -- ds50013Minor allele frequency- T:0.03WA NA EA 242
    rs341197391,2
    C--32546152(+) CTGGAA/GTGAAA 1 -- ds50010--------
    rs347776211,2
    C--32546158(+) TGAAAA/CACTAT 1 -- ds50010--------
    rs1435890011,2
    --32546164(+) ACTATA/GCACTA 3 -- ds50010--------
    rs1162055861,2
    C,F--32546167(+) ATACAC/GTAATT 3 -- ds50013Minor allele frequency- G:0.04WA NA EA 358
    rs356878481,2
    C,F--32546175(+) ATTTAA/C/GAGTTA 1 -- ds50012NA 4
    rs356821441,2
    C--32546183(+) TTATAA/GATACA 1 -- ds50010--------
    rs360616181,2
    C--32546189(+) ATACAA/CAATAT 1 -- ds50010--------
    rs168714021,2
    C,F--32546191(+) ACAAAA/GTATTG 3 -- ds50016Minor allele frequency- G:0.15MN NA WA 432
    rs1166010731,2
    F--32546192(+) CAAAAT/CATTGT 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs37633331,2
    C,H--32546201(+) GTAGAT/CGAGAT 3 -- ds50011Minor allele frequency- C:0.00NA 2
    rs92696561,2
    C,F--32546203(+) AGACGG/AGATGA 3 -- ds50012Minor allele frequency- A:0.38MN NA 8
    rs92696571,2
    C,F--32546205(+) ACGAGG/ATGAAG 3 -- ds50011Minor allele frequency- A:0.50MN 6
    rs668801591,2
    C--32546208(+) AGATG-/AAGA  
            
    AAGAG
    1 -- ds50010--------
    rs668508121,2
    C--32546210(+) ATGAA-/GAAAGA 3 -- ds50010--------
    rs92797231,2
    C--32546214(+) AGAAA-/A/GGTTCT 1 -- ds50010--------
    rs341078671,2
    C,F--32546214(-) GAACTC/TTTTCT 1 -- ds50013Minor allele frequency- T:0.40NA MN 10
    rs671707341,2
    C--32546214(+) AGAAA-/GAGTTC 1 -- ds50010--------
    rs1445261781,2
    --32546224(+) CTGATC/TGACTT 1 -- ds50010--------
    rs92696591,2
    C,F--32546233(+) TTGCTG/AGCTGG 3 -- ds50012Minor allele frequency- A:0.14WA NA 238
    rs715404291,2
    C--32546235(+) GCTGGT/CTGGTT 3 -- ds50011Minor allele frequency- C:0.00NA 2
    rs344137891,2
    C--32546248(+) TCATC-/TCATGTTT 1 -- ds50010--------
    rs412851691,2
    C--32546249(+) CATCT-/CA/CAT
            
    TGTTT
    2 -- ds5001 cds10--------
    rs92696601,2
    C--32546253(+) TCATGG/TTTGCC 3 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs92696611,2
    C,F--32546259(+) TTGCCC/AAGTTT 3 -- ds50014Minor allele frequency- A:0.45NA MN WA CSA 11
    rs352679681,2
    C--32546274(+) CAGTTC/GTTATA 1 -- ds50010--------
    rs715404301,2
    C--32546278(+) TGTTAT/CAGTCT 3 -- ds50013Minor allele frequency- C:0.03NA WA 240
    rs347460931,2
    C--32546291(+) TCTCAA/GTTTTT 3 -- ds50010--------
    rs351135481,2
    C--32546299(+) TTTATA/GCATTG 3 -- ds50010--------
    rs1421130431,2
    --32546300(+) TTATGC/TATTGC 1 -- ds50010--------
    rs412871581,2
    C,F--32546302(+) ATGCAC/TTGCCT 3 -- ds50012Minor allele frequency- T:0.50WA 4
    rs358131131,2
    C,F--32546304(+) GCATTG/ACCTTT 3 -- ds50011Minor allele frequency- A:0.07NA 120
    rs1164312251,2
    --32546305(+) CATTGC/TCTTTT 1 -- ds50010--------
    rs1124815731,2
    C--32546310(+) CCTTTG/TTAAAT 3 -- ds50010--------
    rs350531981,2
    C--32546312(+) TTTTTA/GAATGT 3 -- ds50010--------
    rs92696621,2
    C,F--32546315(+) TTAAAT/CGTTAG 3 -- ds50012Minor allele frequency- C:0.38NA MN 8
    rs92696631,2
    C,F--32546316(+) TAAATG/ATTAGG 3 -- ds50011Minor allele frequency- A:0.50MN 6
    rs412871621,2
    C--32546321(+) GTTAGC/GATTAC 3 -- ds50012Minor allele frequency- G:0.25WA 4
    rs356882801,2
    C--32546322(+) TTAGGA/TTTACT 3 -- ds50010--------
    rs2003661831,2
    --32546324(+) AGGAT-/TACTTTTT 3 -- ds50010--------
    rs92696641,2
    C--32546333(+) TTTTTA/GATTGA 3 -- ds50010--------
    rs356512391,2
    C--32546357(+) TATAGC/TATATT 3 -- ds50012Minor allele frequency- T:0.25NA WA 4
    rs92696651,2
    C,H--32546358(+) ATAGTA/GTATTT 3 -- ds50012Minor allele frequency- G:0.25NA WA 4
    rs92696661,2
    C--32546366(+) TTTATA/GTTGTA 3 -- ds50010--------
    rs357942741,2
    C--32546368(+) TATGTC/G/TGTACA 3 -- ds50010--------
    rs359910271,2
    C--32546372(+) TTGTAC/GAGCAT 1 -- ds50011Minor allele frequency- G:0.00NA 2
    rs92696671,2
    C--32546375(+) TACAGA/CATGAA 3 -- ds50010--------
    rs412871661,2
    C,F--32546387(+) TTTTGA/TTATAT 1 -- ds50012Minor allele frequency- T:0.07WA NA 238
    rs92696681,2
    C--32546394(+) ATATGC/GCTATA 3 -- ds50012Minor allele frequency- G:0.00NA WA 4
    rs69263381,2
    C,F,A--32546410(+) GAATGT/ACTAAA 1 -- ds50011Minor allele frequency- A:0.09WA 118
    rs92696691,2
    C--32546418(+) AAATCA/CAGCTA 1 -- ds50012Minor allele frequency- C:0.25NA WA 4
    rs92696701,2
    C--32546421(+) tccagC/G/Ttattt 1 -- ds50011WA 2
    rs92696711,2
    C--32546427(+) tatttT/Aacata 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs92696721,2
    C--32546433(+) ACATAT/CGCATT 3 -- ds50012Minor allele frequency- C:0.25NA WA 4
    rs412871781,2
    C--32546434(+) CATACA/GCATTA 1 -- ds50010--------
    rs715404331,2
    C--32546435(+) ATACGT/CATTAC 3 -- ds50011Minor allele frequency- C:0.00NA 2
    rs728476851,2
    C,F--32546446(+) CTCACA/GCACTC 3 -- ds50012Minor allele frequency- G:0.11WA NA 238
    rs92696731,2
    C--32546447(+) TCACAT/CACTCA 3 -- ds50016Minor allele frequency- C:0.30WA CSA NA EA 363
    rs353331151,2
    C,F,H--32546454(+) CTCATG/TACATA 1 -- ds50011Minor allele frequency- T:0.30NS 168
    rs412871821,2
    C,F--32546458(+) TGACAT/CATACA 1 -- ds50013Minor allele frequency- C:0.21WA NA EA 358
    rs412871861,2
    C,F--32546460(+) ACATAT/CACATG 1 -- ds50013Minor allele frequency- C:0.19WA NA EA 358
    rs412871901,2
    C,F--32546463(+) TATACA/C/GTGAAA 3 -- ds50013WA NA EA 358
    rs412871941,2
    C,F--32546480(+) ATTCTA/GTTGGA 1 -- ds50013Minor allele frequency- G:0.15WA NA EA 358
    rs69263841,2
    C,A--32546483(+) CTATTA/GGAAAA 1 -- ds50010--------
    rs92696741,2
    C,F--32546485(+) ATTGGG/AAAATA 3 -- ds50014Minor allele frequency- A:0.27MN NA WA CSA 11
    rs1405302641,2
    --32546492(+) ATAAT-/CTTC  
            
    CTTCC
    1 -- ds50010--------
    rs2014693911,2
    --32546496(+) ATCTT-/CCCTTT 3 -- ds50010--------
    rs1416432181,2
    C--32546499(+) TCCCT-/CCCTTTTTC
    /TTTTCTTTTC
    TTTTC
    2 -- ds5001 cds10--------
    rs92818621,2
    C--32546509(+) TTTTC-/TTTTC/TTTT
    CTTTTC
    /TTTTT
    ATTTT
    1 -- ds50011NA 2
    rs92696751,2
    C--32546515(+) ATTTTT/CTGTCT 3 -- ds50015Minor allele frequency- C:0.27NA CSA WA EA 361
    rs354631521,2
    C--32546520(+) CTGTCC/TTTGGA 1 -- ds50010--------
    rs344844071,2
    C--32546525(+) TTTGGA/GGCCAA 1 -- ds50010--------
    rs355281151,2
    C,F--32546541(+) CCAGAT/CGATAT 3 -- ds50012Minor allele frequency- C:0.05WA EA 238
    rs348647181,2
    C--32546542(+) CAGATA/GATATT 1 -- ds50010--------
    rs348340541,2
    C--32546545(+) ATGATA/TTTTAA 1 -- ds50010--------
    rs348397591,2
    C,F--32546557(+) TCCATC/GTTTGA 1 -- ut313Minor allele frequency- G:0.18WA NA EA 358
    rs1141038961,2
    F--32546559(+) CATCTT/GTGAGA 1 -- ut311Minor allele frequency- G:0.12NA 120
    rs11418831,2
    C,F--32546592(-) CTGTAC/TGACAA 3 -- ut315Minor allele frequency- T:0.20MN WA NA EA 366
    rs10602701,2
    C,F--32546603(-) CTGTAC/TTCACC 3 -- ut31 ese36Minor allele frequency- T:0.23MN WA CSA NA EA 367
    rs32056841,2
    C--32546614(-) CTCCCA/GTGCAT 1 -- ut310--------
    rs10647171,2
    C,F--32546615(-) CCTCCT/CGTGCA 3 -- ut31 ese37Minor allele frequency- C:0.32MN WA CSA NA EA 551
    rs1854480401,2
    --32546619(+) CGGGAG/TGCCAT 1 -- ut310--------
    rs69208231,2
    C,F,A--32546622(+) GAGGCC/AATACG 1 -- ut311Minor allele frequency- A:0.10WA 118
    rs10647151,2
    C,F--32546626(-) AAACCC/G/TTATGG 6 -- ut318MN WA CSA NA EA 553
    rs17291,2
    C--32546629(+) TACGGA/G/TTTAGG 2 -- ut310--------
    rs1181267431,2
    C,F--32546631(+) CGGTTT/CAGGCA 1 -- ut311Minor allele frequency- C:0.05EA 120
    rs345427521,2
    C--32546652(+) CAAAAC/GTTGAA 1 -- ut310--------
    rs801360181,2
    C--32546654(+) AAAGTG/TGAAGA 3 -- ut310--------
    rs1997033841,2
    --32546654(+) AAGTT-/GGAAGA 3 -- ut310--------
    rs32010691,2
    C,F--32546665(-) GCAGCA/C/GCCTCA 2 -- ut312NA EA 240
    rs10647131,2
    C,F--32546666(-) GGCAGC/TGCCTC 1 -- ut31 ese33Minor allele frequency- T:0.27MN NA 310
    rs349811301,2
    C--32546670(-) TGATGA/GCAGCG 3 -- ut310--------
    rs10647121,2
    C,F--32546673(-) CATTGA/GTGGCA 3 -- ut311Minor allele frequency- G:0.03MN 184
    rs17301,2
    C--32546674(+) GCCATC/TAATGC 1 -- ut310--------
    rs10601901,2
    C,F--32546677(-) CCAGCT/ATTGAT 1 -- ut312Minor allele frequency- A:0.47MN 368
    rs716851351,2
    C--32546680(+) ATGCT-/TGGGGAC 1 -- ut310--------
    rs92818631,2
    C--32546681(+) TGCTG-/G/TG  
            
    GGACT
    2 -- ut310--------
    rs10601851,2
    C--32546684(-) TGAAGC/TCCCAG 1 -- ut31 ese30--------
    rs32084091,2
    C,F--32546696(-) CTGCCC/TTTGGC 1 -- ut314Minor allele frequency- T:0.18CSA WA NA EA 360
    rs10647101,2
    C,F--32546697(-) CCTGCC/TCTTGG 1 -- ut31 ese31Minor allele frequency- T:0.28MN 184
    rs10647091,2
    C--32546698(-) TCCTGC/TCCTTG 1 -- ut31 ese30--------
    rs32000471,2
    C--32546699(-) CTCCTA/GCCCTT 1 -- ut310--------
    rs1138043751,2
    C--32546703(+) GCAGGG/AGCTGA 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs10601761,2
    C,F,A--32546704(-) CTCAGC/TTCCTG 3 -- ut31 ese36Minor allele frequency- T:0.39MN WA NA EA 546
    rs17321,2
    C,F--32546711(+) TGAGGA/CAGCCA 1 -- ut312Minor allele frequency- C:0.43MN NA 304
    rs1420783391,2
    C--32546726(+) GGAGGA/GCATTT 3 -- ut310--------
    rs1128711301,2
    F--32546727(+) GAGGAC/TATTTT 3 -- ut313Minor allele frequency- T:0.10CSA WA 122
    rs1485824991,2
    C--32546736(+) TCTGC-/AGAGTTG 1 -- ut310--------
    rs32000441,2
    C--32546739(-) CGGCAA/G/TCTGCA 2 -- ut310--------
    rs10647071,2
    C,F--32546743(-) GGTTCA/G/TGCAAC 6 -- ut31 ese38MN WA CSA NA EA 370
    rs10601291,2
    C,F--32546758(-) GACCTG/AGTTGC 3 -- ut31 ese32Minor allele frequency- A:0.50WA NA 4
    rs1137345981,2
    C,F--32546761(+) ACCAGG/ATCCTG 1 -- ut313Minor allele frequency- A:0.21WA NA EA 358
    rs340229241,2
    C--32546765(+) GGTCCA/G/TGAGAA 2 -- ut311CSA 1
    rs10600811,2
    C--32546781(-) TCCACA/GAGAGA 3 -- ut316Minor allele frequency- G:0.22MN WA CSA NA EA 546
    rs1163588971,2
    C,F--32546782(+) CTCTTG/ATGGAA 1 -- ut313Minor allele frequency- A:0.18WA NA EA 358
    rs1820308001,2
    C--32546783(+) TCTTGC/TGGAAG 3 -- ut310--------
    rs32008981,2
    C--32546792(-) GCAGTC/TATTCT 1 -- ut310--------
    rs11418691,2
    C--32546794(-) TGGCAC/GTTATT 1 -- ut310--------
    rs10647011,2
    C,F--32546795(-) TTGGCT/AGTTAT 3 -- ut312Minor allele frequency- A:0.43MN CSA 7
    rs718646781,2
    C--32546799(+) CTGCC-/AAGCAG 1 -- ut310--------
    rs92696881,2
    C,F--32546800(+) TGCCAG/AGCAGG 3 -- ut311Minor allele frequency- A:0.50MN 6
    rs31807991,2
    C,F--32546802(-) TTCCTA/C/G/
            
    CTTGG
    3 -- ut311MN 6
    rs31802681,2
    C,F--32546803(-) TTTCCC/TGCTTG 3 -- ut311Minor allele frequency- T:0.50MN 6
    rs123631,2
    C,F--32546805(-) GCTTTC/G/TCTGCT 6 -- ut31 ese30--------
    rs10646991,2
    C,F--32546806(-) AGCTTC/TCCTGC 1 -- ut311Minor allele frequency- T:0.10MN 184
    rs362177301,2
    C,F--32546818(-) TGCAGG/AATGAA 3 -- ut314Minor allele frequency- A:0.09WA NA EA EU 937
    rs1462927381,2
    C,F--32546821(+) ATCCTG/TCAAAG 3 -- ut311Minor allele frequency- T:0.01EU 591
    rs2008495251,2
    C--32546824(+) CTGCAA/GAGCCG 3 -- ut310--------
    rs10646971,2
    C,F--32546828(-) GCCCCA/GGCTTT 3 -- ut313Minor allele frequency- G:0.10MN WA EU 735
    rs362177281,2
    C,F--32546832(-) TTCTGC/TCCCGG 3 -- ut311Minor allele frequency- T:0.08EU 580
    rs10646951,2
    C,F,H--32546833(-) TTTCTG/TCCCCG 3 -- ut312Minor allele frequency- T:0.49MN 368
    rs2005385921,2
    C,F--32546836(+) GGCAGA/TAAGTT 3 -- ut311Minor allele frequency- T:0.01EU 593
    rs10646941,2
    C--32546838(-) AGAACC/TTTCTG 3 -- ut310--------
    rs10646921,2
    C,F--32546839(-) AAGAAC/TTTTCT 3 -- ut311Minor allele frequency- T:0.22EU 337
    rs2020538521,2
    C,F--32546843(+) AGTTCT/CTCCTT 3 -- ut311Minor allele frequency- C:0.08EU 339
    rs10646911,2
    C--32546846(-) TTCAAA/GGAAGA 1 -- ut310--------
    rs10599201,2
    C,F--32546849(-)