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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HLA-DRB1 Gene

protein-coding GIFtS: 63
GCID: GC06M032546

major histocompatibility complex, class II, DR beta 1

(Previous symbol: HLA-DR1B)

Explore 358 diseases affiliated with
HLA-DRB1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Major Histocompatibility Complex, Class II, DR Beta 1¹ ²		DR13³
HLA-DR1B¹ ² ⁵		DR14³
DRw10² ³		DR16³
DW2.2/DR2.2² ³		DR4³
SS1² ⁵		DR5³
DRB1²		DR7³
HLA-DRB²		DR8³
HLA Class II Histocompatibility Antigen, DR-1 Beta Chain²		DR9³
Human Leucocyte Antigen DRB1²		DRw11³
Lymphocyte Antigen DRB1²		DRw8³
MHC Class II Antigen²		HLA-DRB2³
MHC Class II HLA-DR Beta 1 Chain²		Clone P2-Beta-3³
MHC Class II HLA-DR-Beta Cell Surface Glycoprotein²		MHC Class II Antigen DRB1*1³
MHC Class II HLA-DRw10-Beta²		MHC Class II Antigen DRB1*10³
DR-1³		MHC Class II Antigen DRB1*11³
DR-12³		MHC Class II Antigen DRB1*12³
DR-13³		MHC Class II Antigen DRB1*13³
DR-14³		MHC Class II Antigen DRB1*14³
DR-16³		MHC Class II Antigen DRB1*15³
DR-4³		MHC Class II Antigen DRB1*16³
DR-5³		MHC Class II Antigen DRB1*3³
DR-7³		MHC Class II Antigen DRB1*4³
DR-8³		MHC Class II Antigen DRB1*7³
DR-9³		MHC Class II Antigen DRB1*8³
DR1³		MHC Class II Antigen DRB1*9³
DR12³

External Ids:	HGNC: 4948¹	Entrez Gene: 3123²	Ensembl: ENSG00000196126⁷	OMIM: 142857⁵	UniProtKB: P04229³
	UniProtKB: P01912³	UniProtKB: P13760³	UniProtKB: P13761³	UniProtKB: Q30134³	UniProtKB: Q9TQE0³
	UniProtKB: Q30167³	UniProtKB: P20039³	UniProtKB: Q95IE3³	UniProtKB: Q5Y7A7³	UniProtKB: Q9GIY3³
	UniProtKB: P01911³	UniProtKB: Q29974³

Export aliases for HLA-DRB1 gene to outside databases

Previous GC identifers: GC06U990049 GC06Md32547 GC06M032317 GC06Md32654 GC06M032656

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HLA-DRB1:

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha

(DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by

presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells

(APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6

exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the

transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the

polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing

for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level

five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1

are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6,

DRB7, DRB8 and DRB9. (provided by RefSeq, Jul 2008)

UniProtKB/ace: 2B11_HUMAN, P04229 (see all)

Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and

presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides

of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins

that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous

antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and

for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their

way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal

compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a

source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition

to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74

and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an

antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the

ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen

processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a

small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM

via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules

until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported

to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by

HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the

regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and

efficient peptide loading

Gene Wiki entry for HLA-DRB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NT_113891.2 NT_167248.1 NC_000006.11 NC_018917.1 NT_007592.15 NT_167249.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HLA-DRB1 gene promoter:
HOXA3 AML1a p53 CUTL1 CBF-C YY1 CBF-B CBF-A CP1A CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HLA-DRB1 promoter sequence

Search SABiosciences Chromatin IP Primers for HLA-DRB1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DRB1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.3

HLA-DRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-DRB1 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M032546: view genomic region (about GC identifiers)

Start:	32,546,546 bp from pter	End:	32,557,625 bp from pter
Size:	11,080 bases	Orientation:	minus strand

2 alternative locations:

Chr6-,ALT_REF_LOCI_2 32,475,947-32,528,486

Chr6-,ALT_REF_LOCI_7 32,510,207-32,722,298

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: 2B11_HUMAN, P04229 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-1 beta chain precursor

Size: 266 amino acids; 29914 Da

Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic

reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant

chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes

sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC

class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of

antigenic peptides

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass

type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome

membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome

membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of

intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation

6/39 PDB 3D structures from and Proteopedia for HLA-DRB1 (see all 39):

1AQD (3D)

1DLH (3D)

1FYT (3D)

1HXY (3D)

1JWM (3D)

1JWS (3D)

Secondary accessions: A4F5N0 A8K098 O62869 P13758 Q06662 Q30116 Q30117 Q5Y7E9 Q7M2H4 Q95461 Q9BCL7

Q9GIK5 Q9MXZ0 Q9MXZ5 Q9TQ91

UniProtKB/Swiss-Prot: 2B13_HUMAN, P01912 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-3 chain precursor

Size: 266 amino acids; 30120 Da

Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic

reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant

chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes

sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC

class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of

antigenic peptides

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass

type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome

membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome

membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of

intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation

1 PDB 3D structure from and Proteopedia for HLA-DRB1:

1A6A (3D)

UniProtKB/Swiss-Prot: 2B14_HUMAN, P13760 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-4 beta chain precursor

Size: 266 amino acids; 30112 Da

Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic

reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant

chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes

sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC

class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of

antigenic peptides

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass

type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome

membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome

membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of

intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation

6/8 PDB 3D structures from and Proteopedia for HLA-DRB1 (see all 8):

1D5M (3D)

1D5X (3D)

1D5Z (3D)

1D6E (3D)

1J8H (3D)

2SEB (3D)

Secondary accessions: O19717 O19739 P13759 Q29875 Q30145 Q9GIX9 Q9GIY4 Q9MY13 Q9XRY5

UniProtKB/Swiss-Prot: 2B17_HUMAN, P13761 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-7 beta chain precursor

Size: 266 amino acids; 29822 Da

Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic

reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant

chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes

sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC

class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of

antigenic peptides

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass

type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome

membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome

membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of

intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation

Secondary accessions: B0UYW1 O46699 O46872

UniProtKB/Swiss-Prot: 2B18_HUMAN, Q30134 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-8 beta chain precursor

Size: 266 amino acids; 30004 Da

Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic

reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant

chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes

sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC

class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of

antigenic peptides

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass

type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome

membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome

membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of

intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation

Secondary accessions: O19718 O19788 Q29968 Q30108 Q30115 Q9BCP0 Q9BCP1 Q9BCP2 Q9BD33 Q9TQ37 Q9UIM9

UniProtKB/Swiss-Prot: 2B19_HUMAN, Q9TQE0 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-9 beta chain precursor

Size: 266 amino acids; 29826 Da

Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic

reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant

chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes

sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC

class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of

antigenic peptides

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass

type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome

membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome

membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of

intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation

Secondary accessions: Q30149

UniProtKB/Swiss-Prot: 2B1A_HUMAN, Q30167 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-10 beta chain precursor

Size: 266 amino acids; 30002 Da

Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic

reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant

chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes

sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC

class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of

antigenic peptides

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass

type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome

membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome

membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of

intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation

Secondary accessions: P01914 Q9MYF5

UniProtKB/Swiss-Prot: 2B1B_HUMAN, P20039 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-11 beta chain precursor

Size: 266 amino acids; 30160 Da

Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic

reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant

chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes

sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC

class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of

antigenic peptides

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass

type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome

membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome

membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of

intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation

Secondary accessions: Q30006 Q9GIX8

UniProtKB/Swiss-Prot: 2B1C_HUMAN, Q95IE3 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-12 beta chain precursor

Size: 266 amino acids; 29878 Da

Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic

reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant

chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes

sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC

class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of

antigenic peptides

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass

type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome

membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome

membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of

intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation

Secondary accessions: A7LA26 B0LUZ6 B6VCX2 B7UDB2 O19585 Q19AF2 Q29771 Q2L9H4 Q2MZ92 Q5EER6 Q5NDB9

Q5UT58 Q5Y7G0 Q768U4 Q7YP04 Q861H8 Q95IT6 Q9BD40

UniProtKB/Swiss-Prot: 2B1D_HUMAN, Q5Y7A7 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-13 beta chain precursor

Size: 266 amino acids; 30008 Da

Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic

reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant

chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes

sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC

class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of

antigenic peptides

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass

type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome

membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome

membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of

intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation

Sequence caution: Sequence=CAB40418.1; Type=Erroneous gene model prediction;

Secondary accessions: A0MWF2 A2ICT1 A4ZXA5 A4ZXA6 A7UHG2 A7X5K7 A8YQE9 B0BK85 B3VTQ3 B5A8Y2 B5A8Y3

B5B9V6 B5QSK8 C0LAB5 O02930 O62889 O78047 P79545 Q14280 Q14QT2 Q19K86 Q1G0Z9 Q1KLJ6 Q29673 Q29720

Q29722 Q29806 Q29833 Q29874 Q29886 Q2MF40 Q2YHQ2 Q30112 Q3LA93 Q3LA94 Q3LA95 Q3LA96 Q3LA97 Q3LA98

Q3LA99 Q3LAA0 Q3LAA1 Q3LAA2 Q3MQ60 Q53IG1 Q56FP2 Q56FP3 Q58F52 Q5K3W2 Q5UBA2 Q5W3L4 Q6REE2 Q6U387

Q701T1 Q70Q85 Q768U2 Q7YP03 Q7YQ26 Q7YQA3 Q860E5 Q860H8 Q860Z3 Q861G6 Q861H0 Q861H4 Q8HWQ6 Q8WMA0

Q95389 Q95HL1 Q96HZ9 Q9BCP5 Q9BD21 Q9GIP3 Q9GJ25 Q9GJ60 Q9GJF8 Q9GJF9 Q9GJG0 Q9MY45 Q9MY56 Q9TPW3

Q9TPW9 Q9TPX4 Q9UBY1 Q9UIN0 Q9XRX1 Q9Y453

UniProtKB/Swiss-Prot: 2B1E_HUMAN, Q9GIY3 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-14 beta chain precursor

Size: 266 amino acids; 30139 Da

Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic

reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant

chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes

sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC

class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of

antigenic peptides

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass

type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome

membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome

membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of

intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation

Sequence caution: Sequence=CAB45249.1; Type=Erroneous gene model prediction;

Secondary accessions: A0N0W1 A2TGX3 A4ZY86 A5H000 A5HKN8 A7DZP9 A7X5B1 A7X5B7 A7X5E0 A7X5E6 A7X5H8

A9JPG0 B1GWE7 B2CR03 B2LVF9 B2NJ29 B2ZCY1 B3VTP8 B5B8U0 B5B9V5 B5LZ25 B6VEL9 B9VRA4 B9X248 O02876

O46793 O77969 O78210 Q0PQ39 Q155F7 Q1AP33 Q1JRP3 Q27PR6 Q27PR7 Q29734 Q29770 Q29772 Q29800 Q2A120

Q2HZE5 Q2LE76 Q2MJA6 Q2VQU1 Q307W5 Q31636 Q3LA87 Q3LA88 Q3LA89 Q3LA90 Q3LA91 Q3LA92 Q3T919 Q4PRC3

Q4PRC5 Q4VZY7 Q56FP1 Q5BM92 Q5U9W6 Q683P7 Q70GL2 Q7YNY9 Q7YQA5 Q860D8 Q860D9 Q860S0 Q861H5 Q861H7

Q8MH59 Q8MH60 Q8WLU3 Q95348 Q95HK1 Q95HL0 Q95IG2 Q9GIL5 Q9GIL6 Q9GIY0 Q9GIY1 Q9GIY2 Q9GJ56 Q9GJ57

Q9GJ58 Q9TPB6 Q9TPW1 Q9XRY4 Q9Y4H7

UniProtKB/Swiss-Prot: 2B1F_HUMAN, P01911 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-15 beta chain precursor

Size: 266 amino acids; 29966 Da

Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic

reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant

chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes

sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC

class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of

antigenic peptides

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass

type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome

membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome

membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of

intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation

Miscellaneous: The chain shown constituted about 70% of a pool of at least seven similar beta chains

3 PDB 3D structures from and Proteopedia for HLA-DRB1:

1BX2 (3D)

1YMM (3D)

2WBJ (3D)

Secondary accessions: Q29790 Q29975 Q30142 Q30166 Q32MY7 Q56FN9 Q5Y7B0 Q5Y7B9

UniProtKB/Swiss-Prot: 2B1G_HUMAN, Q29974 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-16 beta chain precursor

Size: 266 amino acids; 30030 Da

Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic

reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant

chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes

sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC

class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of

antigenic peptides

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass

type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome

membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome

membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of

intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation

Secondary accessions: A7X5J4 O98212 Q0PGR5 Q29792 Q30120 Q30159 Q30200 Q3HUP9 Q3KTM1 Q3LA84 Q6T865

Q95383

Explore the universe of human proteins at neXtProt for HLA-DRB1: NX_Q29974

Post-translational modifications:

Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC

class II (Probable)¹

View modification sites using PhosphoSitePlus² (HLA-DRB4)

View neXtProt modification sites for NX_Q29974

HLA-DRB1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001230894.1 NP_002115.2

ENSEMBL proteins:

ENSP00000353099

Reactome Protein details: Q30167 Q5Y7A7 P04229 Q9TQE0 Q9GIY3 P01911 Q29974 P20039 Q95IE3 P01912 P13760 Q30134 P13761
Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HLA-DRB1

Gene Ontology (GO): 5/17 cellular component terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	TAS	--
GO:0005765	lysosomal membrane	TAS	--
GO:0005789	endoplasmic reticulum membrane	--	--
GO:0005794	Golgi apparatus	--	--
GO:0005886	plasma membrane	TAS	--

HLA-DRB1 for ontologies About GeneDecksing

HLA-DRB1 Antibody Products:

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	Novus Biologicals HLA-DRB1 Antibodies
	Abcam antibodies for HLA-DRB1
	Uscn Antibodies for HLA-DRB1
	Search ThermoFisher Antibodies for HLA-DRB1

Assay Products for HLA-DRB1:

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	GenScript Custom Assay Services for HLA-DRB1
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	Uscn ELISAs and CLIAs for HLA-DRB1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HLA-DRB1 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR011162 MHC_I/II-like_Ag-recog

IPR000353 MHC_II_b_N

IPR013783 Ig-like_fold

IPR014745 MHC_II_a/b_N

IPR003597 Ig_C1-set

Graphical View of Domain Structure for InterPro Entry P04229

Graphical View of Domain Structure for InterPro Entry P01912

Graphical View of Domain Structure for InterPro Entry P13760

Graphical View of Domain Structure for InterPro Entry P13761

Graphical View of Domain Structure for InterPro Entry Q30134

Graphical View of Domain Structure for InterPro Entry Q9TQE0

Graphical View of Domain Structure for InterPro Entry Q30167

Graphical View of Domain Structure for InterPro Entry P20039

Graphical View of Domain Structure for InterPro Entry Q95IE3

Graphical View of Domain Structure for InterPro Entry Q5Y7A7

Graphical View of Domain Structure for InterPro Entry Q9GIY3

Graphical View of Domain Structure for InterPro Entry P01911

Graphical View of Domain Structure for InterPro Entry Q29974

ProtoNet protein and cluster: P04229

2 Blocks protein families:

IPB000353 Class II histocompatibility antigen

IPB003597 Immunoglobulin C-type

UniProtKB/Swiss-Prot: 2B11_HUMAN, P04229

Similarity: Belongs to the MHC class II family

Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

UniProtKB/Swiss-Prot: 2B13_HUMAN, P01912

Similarity: Belongs to the MHC class II family

Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

UniProtKB/Swiss-Prot: 2B14_HUMAN, P13760

Similarity: Belongs to the MHC class II family

Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

UniProtKB/Swiss-Prot: 2B17_HUMAN, P13761

Similarity: Belongs to the MHC class II family

Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

UniProtKB/Swiss-Prot: 2B18_HUMAN, Q30134

Similarity: Belongs to the MHC class II family

Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

UniProtKB/Swiss-Prot: 2B19_HUMAN, Q9TQE0

Similarity: Belongs to the MHC class II family

Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

UniProtKB/Swiss-Prot: 2B1A_HUMAN, Q30167

Similarity: Belongs to the MHC class II family

Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

UniProtKB/Swiss-Prot: 2B1B_HUMAN, P20039

Similarity: Belongs to the MHC class II family

Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

UniProtKB/Swiss-Prot: 2B1C_HUMAN, Q95IE3

Similarity: Belongs to the MHC class II family

Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

UniProtKB/Swiss-Prot: 2B1D_HUMAN, Q5Y7A7

Similarity: Belongs to the MHC class II family

Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

UniProtKB/Swiss-Prot: 2B1E_HUMAN, Q9GIY3

Similarity: Belongs to the MHC class II family

Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

UniProtKB/Swiss-Prot: 2B1F_HUMAN, P01911

Similarity: Belongs to the MHC class II family

Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

UniProtKB/Swiss-Prot: 2B1G_HUMAN, Q29974

Similarity: Belongs to the MHC class II family

Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:
UniProtKB/ace: 2B11_HUMAN, P04229 (see all)