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HLA-DRB1 Gene

protein-coding   GIFtS: 65
GCID: GC06M032546

Major Histocompatibility Complex, Class II, DR Beta 1


(Previous symbol: HLA-DR1B)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Major Histocompatibility Complex, Class II, DR Beta 11 2     DR133
HLA-DR1B1 2     DR143
DRw102 3     DR163
DW2.2/DR2.22 3     DR43
SS12 5     DR53
DRB12     DR73
HLA-DRB2     DR83
HLA Class II Histocompatibility Antigen, DR-1 Beta Chain2     DR93
Human Leucocyte Antigen DRB12     DRw113
Lymphocyte Antigen DRB12     DRw83
MHC Class II Antigen2     HLA-DRB23
MHC Class II HLA-DR Beta 1 Chain2     Clone P2-Beta-33
MHC Class II HLA-DR-Beta Cell Surface Glycoprotein2     MHC Class II Antigen DRB1*13
MHC Class II HLA-DRw10-Beta2     MHC Class II Antigen DRB1*103
DR-13     MHC Class II Antigen DRB1*113
DR-123     MHC Class II Antigen DRB1*123
DR-133     MHC Class II Antigen DRB1*133
DR-143     MHC Class II Antigen DRB1*143
DR-163     MHC Class II Antigen DRB1*153
DR-43     MHC Class II Antigen DRB1*163
DR-53     MHC Class II Antigen DRB1*33
DR-73     MHC Class II Antigen DRB1*43
DR-83     MHC Class II Antigen DRB1*73
DR-93     MHC Class II Antigen DRB1*83
DR13     MHC Class II Antigen DRB1*93
DR123     

External Ids:    HGNC: 49481   Entrez Gene: 31232   Ensembl: ENSG000001961267   OMIM: 1428575   UniProtKB: P042293   
UniProtKB: P019123   UniProtKB: P137603   UniProtKB: P137613   UniProtKB: Q301343   UniProtKB: Q9TQE03   
UniProtKB: Q301673   UniProtKB: P200393   UniProtKB: Q95IE33   UniProtKB: Q5Y7A73   UniProtKB: Q9GIY33   
UniProtKB: P019113   UniProtKB: Q299743   

Export aliases for HLA-DRB1 gene to outside databases

Previous GC identifers: GC06U990049 GC06Md32547 GC06M032317 GC06Md32654 GC06M032656


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HLA-DRB1 Gene:
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an
alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system
by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen
presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa.
It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular
domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule
the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1
alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney
transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is
present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4
and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. (provided by RefSeq, Jul 2008)

GeneCards Summary for HLA-DRB1 Gene:
HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) is a protein-coding gene. Diseases associated with HLA-DRB1 include bullous pemphigoid, and rhizomelic pseudopolyarthritis. GO annotations related to this gene include MHC class II receptor activity and peptide antigen binding. An important paralog of this gene is HLA-DRB5.

UniProtKB/Swiss-Prot: 2B11_HUMAN, P04229 (see all)
Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
(class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the
regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
efficient peptide loading

Gene Wiki entry for HLA-DRB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NT_167245.2  NT_167246.2  NT_113891.3  NT_167248.2  NC_000006.12  NC_018917.2  NT_007592.16  NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HLA-DRB1 gene promoter:
         HOXA3   AML1a   p53   CUTL1   CBF-C   YY1   CBF-B   CBF-A   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLA-DRB1 promoter sequence
   Search Chromatin IP Primers for HLA-DRB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-DRB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

HLA-DRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-DRB1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032546:  view genomic region     (about GC identifiers)

Start:
32,546,546 bp from pter      End:
32,557,625 bp from pter
Size:
11,080 bases      Orientation:
minus strand

4 alternative locations:
Chr6-,NT_167248 3,784,600-3,797,961      Chr6-,NT_167244 3,774,424-3,787,494      Chr6-,NT_113891.2 3,998,151-4,011,502     
Chr6-,NT_167249 3,978,426-3,993,112     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: 2B11_HUMAN, P04229 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen, DRB1-1 beta chain precursor  
Size: 266 amino acids; 29914 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Selected PDB 3D structures from and Proteopedia for HLA-DRB1 (see all 40):
1AQD (3D)        1DLH (3D)        1FYT (3D)        1HXY (3D)        1JWM (3D)        1JWS (3D)    
Secondary accessions: A4F5N0 A8K098 O62869 P13758 Q06662 Q30116 Q30117 Q5Y7E9 Q7M2H4 Q95461
Q9BCL7 Q9GIK5 Q9MXZ0 Q9MXZ5 Q9TQ91

UniProtKB/Swiss-Prot: 2B13_HUMAN, P01912 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-3 chain precursor  
Size: 266 amino acids; 30120 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
1 PDB 3D structure from and Proteopedia for HLA-DRB1:
1A6A (3D)    

UniProtKB/Swiss-Prot: 2B14_HUMAN, P13760 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-4 beta chain precursor  
Size: 266 amino acids; 30112 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Selected PDB 3D structures from and Proteopedia for HLA-DRB1 (see all 16):
1D5M (3D)        1D5X (3D)        1D5Z (3D)        1D6E (3D)        1J8H (3D)        2SEB (3D)    
Secondary accessions: O19717 O19739 P13759 Q29875 Q30145 Q9GIX9 Q9GIY4 Q9MY13 Q9XRY5

UniProtKB/Swiss-Prot: 2B17_HUMAN, P13761 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-7 beta chain precursor  
Size: 266 amino acids; 29822 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Secondary accessions: B0UYW1 O46699 O46872

UniProtKB/Swiss-Prot: 2B18_HUMAN, Q30134 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-8 beta chain precursor  
Size: 266 amino acids; 30004 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Secondary accessions: O19718 O19788 Q29968 Q30108 Q30115 Q9BCP0 Q9BCP1 Q9BCP2 Q9BD33 Q9TQ37
Q9UIM9

UniProtKB/Swiss-Prot: 2B19_HUMAN, Q9TQE0 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-9 beta chain precursor  
Size: 266 amino acids; 29826 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Secondary accessions: Q30149

UniProtKB/Swiss-Prot: 2B1A_HUMAN, Q30167 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-10 beta chain precursor  
Size: 266 amino acids; 30002 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Secondary accessions: P01914 Q9MYF5

UniProtKB/Swiss-Prot: 2B1B_HUMAN, P20039 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-11 beta chain precursor  
Size: 266 amino acids; 30160 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Secondary accessions: Q30006 Q9GIX8

UniProtKB/Swiss-Prot: 2B1C_HUMAN, Q95IE3 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-12 beta chain precursor  
Size: 266 amino acids; 29878 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Secondary accessions: A7LA26 B0LUZ6 B6VCX2 B7UDB2 O19585 Q19AF2 Q29771 Q2L9H4 Q2MZ92 Q5EER6
Q5NDB9 Q5UT58 Q5Y7G0 Q768U4 Q7YP04 Q861H8 Q95IT6 Q9BD40

UniProtKB/Swiss-Prot: 2B1D_HUMAN, Q5Y7A7 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-13 beta chain precursor  
Size: 266 amino acids; 30008 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Sequence caution: Sequence=CAB40418.1; Type=Erroneous gene model prediction;
Secondary accessions: A0MWF2 A2ICT1 A4ZXA5 A4ZXA6 A7UHG2 A7X5K7 A8YQE9 B0BK85 B3VTQ3 B5A8Y2
B5A8Y3 B5B9V6 B5QSK8 C0LAB5 O02930 O62889 O78047 P79545 Q14280 Q14QT2 Q19K86 Q1G0Z9 Q1KLJ6
Q29673 Q29720 Q29722 Q29806 Q29833 Q29874 Q29886 Q2MF40 Q2YHQ2 Q30112 Q3LA93 Q3LA94 Q3LA95
Q3LA96 Q3LA97 Q3LA98 Q3LA99 Q3LAA0 Q3LAA1 Q3LAA2 Q3MQ60 Q53IG1 Q56FP2 Q56FP3 Q58F52 Q5K3W2
Q5UBA2 Q5W3L4 Q6REE2 Q6U387 Q701T1 Q70Q85 Q768U2 Q7YP03 Q7YQ26 Q7YQA3 Q860E5 Q860H8 Q860Z3
Q861G6 Q861H0 Q861H4 Q8HWQ6 Q8WMA0 Q95389 Q95HL1 Q96HZ9 Q9BCP5 Q9BD21 Q9GIP3 Q9GJ25 Q9GJ60
Q9GJF8 Q9GJF9 Q9GJG0 Q9MY45 Q9MY56 Q9TPW3 Q9TPW9 Q9TPX4 Q9UBY1 Q9UIN0 Q9XRX1 Q9Y453

UniProtKB/Swiss-Prot: 2B1E_HUMAN, Q9GIY3 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-14 beta chain precursor  
Size: 266 amino acids; 30139 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Sequence caution: Sequence=CAB45249.1; Type=Erroneous gene model prediction;
Secondary accessions: A0N0W1 A2TGX3 A4ZY86 A5H000 A5HKN8 A7DZP9 A7X5B1 A7X5B7 A7X5E0 A7X5E6
A7X5H8 A9JPG0 B1GWE7 B2CR03 B2LVF9 B2NJ29 B2ZCY1 B3VTP8 B5B8U0 B5B9V5 B5LZ25 B6VEL9 B9VRA4
B9X248 O02876 O46793 O77969 O78210 Q0PQ39 Q155F7 Q1AP33 Q1JRP3 Q27PR6 Q27PR7 Q29734 Q29770
Q29772 Q29800 Q2A120 Q2HZE5 Q2LE76 Q2MJA6 Q2VQU1 Q307W5 Q31636 Q3LA87 Q3LA88 Q3LA89 Q3LA90
Q3LA91 Q3LA92 Q3T919 Q4PRC3 Q4PRC5 Q4VZY7 Q56FP1 Q5BM92 Q5U9W6 Q683P7 Q70GL2 Q7YNY9 Q7YQA5
Q860D8 Q860D9 Q860S0 Q861H5 Q861H7 Q8MH59 Q8MH60 Q8WLU3 Q95348 Q95HK1 Q95HL0 Q95IG2 Q9GIL5
Q9GIL6 Q9GIY0 Q9GIY1 Q9GIY2 Q9GJ56 Q9GJ57 Q9GJ58 Q9TPB6 Q9TPW1 Q9XRY4 Q9Y4H7

UniProtKB/Swiss-Prot: 2B1F_HUMAN, P01911 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-15 beta chain precursor  
Size: 266 amino acids; 29966 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Miscellaneous: The chain shown constituted about 70% of a pool of at least seven similar beta chains
3 PDB 3D structures from and Proteopedia for HLA-DRB1:
1BX2 (3D)        1YMM (3D)        2WBJ (3D)    
Secondary accessions: Q29790 Q29975 Q30142 Q30166 Q32MY7 Q56FN9 Q5Y7B0 Q5Y7B9

UniProtKB/Swiss-Prot: 2B1G_HUMAN, Q29974 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-16 beta chain precursor  
Size: 266 amino acids; 30030 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Secondary accessions: A7X5J4 O98212 Q0PGR5 Q29792 Q30120 Q30159 Q30200 Q3HUP9 Q3KTM1 Q3LA84
Q6T865 Q95383

Explore the universe of human proteins at neXtProt for HLA-DRB1: NX_Q29974

Explore proteomics data for HLA-DRB1 at MOPED

Post-translational modifications: 

  • Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of
    MHC class II (Probable)1
  • Ubiquitination2 at Lys254
  • Glycosylation2 at Asn48
  • Modification sites at PhosphoSitePlus (HLA-DRB4)

  • See HLA-DRB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230894.1  NP_002115.2  

    ENSEMBL proteins: 
     ENSP00000353099  
    Reactome Protein details: Q30167 Q5Y7A7 P04229 Q9TQE0 Q9GIY3 P01911 Q29974 P20039 Q95IE3 P01912 P13760 Q30134 P13761

    HLA-DRB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HLA-DRB1
    OriGene Protein Over-expression Lysate for HLA-DRB1
    OriGene MassSpec for HLA-DRB1
    OriGene Custom Protein Services for HLA-DRB1
    GenScript Custom Purified and Recombinant Proteins Services for HLA-DRB1
    Novus Biologicals HLA-DRB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    HLA-DRB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HLA-DRB1
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HLA-DRB1
    OriGene Custom Antibody Services for HLA-DRB1
    Novus Biologicals HLA-DRB1 Antibodies
    Abcam antibodies for HLA-DRB1 (Q30120, P01911, P20039, P13761)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for HLA-DRB1
    LSBio Antibodies in human, mouse, rat for HLA-DRB1

    HLA-DRB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HLA-DRB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HLA-DRB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    HGNC Gene Families:
    HLA: Histocompatibility complex
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    Selected InterPro protein domains (see all 7):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR000353 MHC_II_b_N
     IPR013783 Ig-like_fold
     IPR014745 MHC_II_a/b_N
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry P04229
    Graphical View of Domain Structure for InterPro Entry P01912
    Graphical View of Domain Structure for InterPro Entry P13760
    Graphical View of Domain Structure for InterPro Entry P13761
    Graphical View of Domain Structure for InterPro Entry Q30134
    Graphical View of Domain Structure for InterPro Entry Q9TQE0
    Graphical View of Domain Structure for InterPro Entry Q30167
    Graphical View of Domain Structure for InterPro Entry P20039
    Graphical View of Domain Structure for InterPro Entry Q95IE3
    Graphical View of Domain Structure for InterPro Entry Q5Y7A7
    Graphical View of Domain Structure for InterPro Entry Q9GIY3
    Graphical View of Domain Structure for InterPro Entry P01911
    Graphical View of Domain Structure for InterPro Entry Q29974

    ProtoNet protein and cluster: P04229

    2 Blocks protein domains:
    IPB000353 Class II histocompatibility antigen
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: 2B11_HUMAN, P04229
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B13_HUMAN, P01912
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B14_HUMAN, P13760
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B17_HUMAN, P13761
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B18_HUMAN, Q30134
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B19_HUMAN, Q9TQE0
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1A_HUMAN, Q30167
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1B_HUMAN, P20039
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1C_HUMAN, Q95IE3
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1D_HUMAN, Q5Y7A7
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1E_HUMAN, Q9GIY3
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1F_HUMAN, P01911
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1G_HUMAN, Q29974
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    HLA-DRB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:
    UniProtKB/Swiss-Prot Summary: 2B11_HUMAN, P04229 (see all)
    Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
    and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
    peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
    of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
    hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
    via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
    As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
    contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
    endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
    MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
    epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
    tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
    an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
    of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
    degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
    (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
    the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
    affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
    membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
    Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the
    regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
    efficient peptide loading

         Genatlas biochemistry entry for HLA-DRB1:
    HLA-DR,beta 1 chain,determining DR1,3,4,5 etc

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0023026MHC class II protein complex binding IDA--
    GO:0032395MHC class II receptor activity TAS3456344
    GO:0042605peptide antigen binding ISS--
         
    HLA-DRB1 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidHLA-DRB1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    2B11_HUMAN, P04229: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B13_HUMAN, P01912: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B14_HUMAN, P13760: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B17_HUMAN, P13761: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B18_HUMAN, Q30134: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B19_HUMAN, Q9TQE0: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B1A_HUMAN, Q30167: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B1B_HUMAN, P20039: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B1C_HUMAN, Q95IE3: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B1D_HUMAN, Q5Y7A7: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B1E_HUMAN, Q9GIY3: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B1F_HUMAN, P01911: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B1G_HUMAN, Q29974: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome5
    lysosome5
    plasma membrane5
    vacuole5
    golgi apparatus4
    extracellular2
    nucleus2
    cytoskeleton1
    cytosol1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005765lysosomal membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS3456344
    GO:0009897external side of plasma membrane ISS--

    HLA-DRB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

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    SuperPaths for HLA-DRB1 About   (see all 30)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Allograft rejection
    Allograft rejection0.86
    Intestinal immune network for IgA production0.41
    Allograft Rejection0.86
    Viral myocarditis0.40
    Type I diabetes mellitus0.69
    CTL Mediated Apoptosis0.38
    Graft-versus-host disease0.65
    THC Differentiation Pathway0.38
    2CD28 co-stimulation
    Costimulation by the CD28 family0.44
    CTLA4 Signaling0.30
    3Translocation of ZAP-70 to Immunological synapse
    Translocation of ZAP-70 to Immunological synapse0.83
    PD-1 signaling0.72
    Phosphorylation of CD3 and TCR zeta chains0.83
    Generation of second messenger molecules0.62
    4Immune response Antigen presentation by MHC class II
    Immune response Antigen presentation by MHC class II0.46
    Immune response IL 22 signaling pathway0.31
    G protein signaling N RAS regulation pathway0.46
    5ICos-ICosL Pathway in T-Helper Cell
    ICos-ICosL Pathway in T-Helper Cell0.66
    Calcium Mediated T-Cell Apoptosis0.31
    CD28 Signaling in T-Helper Cell0.66

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HLA-DRB1 (see all 12)
        THC Differentiation Pathway
    Calcium Mediated T-Cell Apoptosis
    IL-4 Pathway
    ICos-ICosL Pathway in T-Helper Cell
    CDC42 Pathway

    Selected GeneGo (Thomson Reuters) Pathways for HLA-DRB1 (see all 6)
        Immune response Antigen presentation by MHC class II
    Immune response ICOS pathway in T-helper cell
    Immune response T cell receptor signaling pathway
    Immune response IL-22 signaling pathway
    G-protein signaling N-RAS regulation pathway

    Selected BioSystems Pathways for HLA-DRB1 (see all 6)
        Cytokines and Inflammatory Response
    Allograft Rejection
    IL12-mediated signaling events
    TCR signaling in naive CD4+ T cells
    IL12 signaling mediated by STAT4

    Selected Reactome Pathways for HLA-DRB1 (see all 7)
        Translocation of ZAP-70 to Immunological synapse
    Interferon gamma signaling
    Downstream TCR signaling
    PD-1 signaling
    MHC class II antigen presentation


    Selected Kegg Pathways  (Kegg details for HLA-DRB1) (see all 22):
        Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Hematopoietic cell lineage
    Intestinal immune network for IgA production


    HLA-DRB1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HLA-DRB1: 
              Multiple Sclerosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HLA-DRB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HLA-DRB1 (P019122 P042292 ENSP000003530994 Q299742, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 200)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235657P018922, ENSP000003885264MINT-8407259 MINT-8407185 STRING: ENSP00000388526
    ENSG00000227993P019032, ENSP000003726084MINT-24881 STRING: ENSP00000372608
    ENSG00000228987P019032, ENSP000004104434MINT-24881 STRING: ENSP00000410443
    HLA-DRAP019032, ENSP000003787864MINT-24881 STRING: ENSP00000378786
    ENSG00000206308P019032, ENSP000003727464MINT-24881 STRING: ENSP00000372746
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002381immunoglobulin production involved in immunoglobulin mediated immune response ISS--
    GO:0002437inflammatory response to antigenic stimulus ISS--
    GO:0002455humoral immune response mediated by circulating immunoglobulin ISS--
    GO:0006955immune response NAS3129499
    GO:0016045detection of bacterium ISS--

    HLA-DRB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HLA-DRB1 (2B1G)

    1 DrugBank Compound for HLA-DRB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glatiramer AcetateCOP-1 (see all 3)147245-92-9targetbinder15371592 11752352

    Selected Novoseek inferred chemical compound relationships for HLA-DRB1 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dr-10 77.3 6 7780115 (1), 9550403 (1), 8754259 (1), 10626740 (1)
    dr-16 73.6 1 9243764 (1)
    dpa 1 73.1 5 8782076 (1), 8863870 (1), 17060025 (1), 10616003 (1) (see all 5)
    oligonucleotide 53.4 22 8117375 (1), 12823773 (1), 15865503 (1), 18718089 (1) (see all 20)
    gold sodium thiomalate 36 2 11093435 (1)
    valine 30.5 4 9098452 (1), 8500529 (1), 10439317 (1), 2369430 (1)
    amino acid 19.7 1 1533151 (1)
    c-peptide 4.17 1 15388265 (1)
    atp 3.36 2 12658812 (2)
    lysine 0 2 7738179 (1), 7612412 (1)

    1 PharmGKB related drug/compound annotation for HLA-DRB1 gene    About this table
    Drug/compound PharmGKB Annotation
    lapatinib



    HLA-DRB1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for HLA-DRB1 gene (2 alternative transcripts): 
    NM_001243965.1  NM_002124.3  

    Unigene Cluster for HLA-DRB1:

    Major histocompatibility complex, class II, DR beta 1
    Hs.534322  [show with all ESTs]
    Unigene Representative Sequence: AK290388
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000360004(uc021yvx.1 uc003obp.4 uc011dqb.1 uc011dqc.1)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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      QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB1

    Additional mRNA sequence: 

    AB062112.2 AF017440.1 AF097680.1 AF436097.1 AF490771.1 AJ011065.1 AK290388.1 AK292140.1 
    AK314834.1 AY052550.1 AY054375.1 BC009234.2 FJ200455.1 HM627215.1 M15068.1 M15178.1 
    M15992.1 M16086.1 M16731.1 M16954.1 M16955.1 M16956.1 M17377.1 M17383.1 
    M17384.1 M17387.1 M20429.1 M20503.1 M25265.1 M27015.1 M27689.1 M30181.1 
    M30182.1 M32578.1 M35980.1 M35981.1 M57648.1 M59803.1 S79787.1 U17380.1 
    U17381.1 U31770.1 U35375.1 U35729.1 U37433.1 U37582.1 U66826.1 U70543.1 
    U95818.1 X99895.1 

    Selected DOTS entries (see all 50):

    DT.92028787  DT.100776434  DT.92410344  DT.121314547  DT.40115364  DT.91706875  DT.92047682  DT.100781798 
    DT.95164729  DT.121314807  DT.95164752  DT.95164731  DT.100778733  DT.99961180  DT.95164743  DT.91802323 
    DT.95129328  DT.97857272  DT.100766538  DT.121314566  DT.121314746  DT.100650571  DT.100776431  DT.91661820 

    Selected AceView cDNA sequences (see all 89):

    M16731 L42143 X02902 AH002891 AF291675 AJ297586 AJ536121 M15073 
    AJ245881 BV207185 BV183568 BV207240 BC024269 BV201637 M17381 BV200472 
    M15070 BV183567 BV200462 BV207191 BV207249 BV207036 M15069 BV207037 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HLA-DRB1 expression in normal human tissues (normalized intensities)      HLA-DRB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGCGCTGA
    HLA-DRB1 Expression
    About this image


    HLA-DRB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
    HLA-DRB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HLA-DRB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534322
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HLA-DRB1: 
              Multiple Sclerosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HLA-DRB1
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-DRB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HLA-DRB1
    QuantiTect SYBR Green Assays in human, mouse, rat HLA-DRB1
    QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DRB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-DRB1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia H2-Eb15 histocompatibility 2, class II antigen E beta   --   17 (17.98 cM) 34305883 
    African clawed frog
    (Xenopus laevis)
    Amphibia D13688.12   -- 78.3(n)    D13688.1 


    ENSEMBL Gene Tree for HLA-DRB1 (if available)
    TreeFam Gene Tree for HLA-DRB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for HLA-DRB1 gene
    HLA-DRB52  HLA-DQA12  HLA-DPA12  HLA-DQB12  HLA-DRA2  HLA-DOB2  HLA-DMA2  HLA-DQB22  
    HLA-DOA2  ENSG000002489932  HLA-DMB2  HLA-DQA22  HLA-DPB12  
    Selected SIMAP similar genes for HLA-DRB1 using alignment to 2155 protein entries:     2B11_HUMAN     F8RHK4_HUMAN     L0BXK2_HUMAN     F2VPA0_HUMAN     B2NJ27_HUMAN     U3PQS9_HUMAN     Q5Y7D7_HUMAN     Q000J6_HUMAN     Q30156_HUMAN     D4P2X4_HUMAN     G0WVD4_HUMAN     F8RHJ4_HUMAN     F2X651_HUMAN     H8WV87_HUMAN     U3PUP7_HUMAN     G9HRQ9_HUMAN     B0LUU3_HUMAN     Q3LAC2_HUMAN     G5EM96_HUMAN     F8RHJ2_HUMAN     A7X5L2_HUMAN     C8XTJ1_HUMAN     U3PRN8_HUMAN     Q5QQ11_HUMAN     A9JJF6_HUMAN     F8R8M8_HUMAN     B5ABX7_HUMAN     B3GDG5_HUMAN     F2X658_HUMAN     M4MD36_HUMAN     E1V2J5_HUMAN     C9WEW2_HUMAN     Q9TPE1_HUMAN     S4T760_HUMAN     C8XTL2_HUMAN     F8SY63_HUMAN     Q3LTJ6_HUMAN     O77971_HUMAN     B3GV30_HUMAN     U3PSS5_HUMAN     A7UHG7_HUMAN     G9FJH9_HUMAN     F2VNW5_HUMAN     I7C0V1_HUMAN     Q0Z850_HUMAN     B0LUD6_HUMAN     Q9MY83_HUMAN     Q9BD47_HUMAN     C0LAC2_HUMAN     A0AQY5_HUMAN     Q6RCP9_HUMAN     G1EMZ0_HUMAN     S4TZG3_HUMAN     H8WV57_HUMAN     C8XTM2_HUMAN     W0HIJ7_HUMAN     G1EMZ4_HUMAN     F2VP99_HUMAN     C8ZLD6_HUMAN     A7UP08_HUMAN     2B1A_HUMAN     N1NTB2_HUMAN     S0F2D2_HUMAN     J7FR35_HUMAN     I6NXM9_HUMAN     G9I2P2_HUMAN     D5FID7_HUMAN     Q860S9_HUMAN     E9LIR7_HUMAN     Q7YQA8_HUMAN     C8C9V6_HUMAN     Q95HK4_HUMAN     G0Z8G3_HUMAN     I7KSM4_HUMAN     S6BVK7_HUMAN     Q861H2_HUMAN     A1A414_HUMAN     Q9TQ70_HUMAN     Q9BCS7_HUMAN     G8GB45_HUMAN     V9N336_HUMAN     Q3LTJ8_HUMAN     E7BYD8_HUMAN     B2G3D1_HUMAN     S5UGG7_HUMAN     M1UZ74_HUMAN     F1CCQ3_HUMAN     B1PL08_HUMAN     I2B1C4_HUMAN     F1CCN1_HUMAN     G4XPL9_HUMAN     R4QGJ7_HUMAN     K0P2W4_HUMAN     D7NST1_HUMAN     C8XTI8_HUMAN     C9E868_HUMAN     E3SGD4_HUMAN     F2X655_HUMAN     F2VNV8_HUMAN     O19730_HUMAN     D2D3G8_HUMAN     E5RVA0_HUMAN     N0A0M7_HUMAN     Q95381_HUMAN     D3U4F2_HUMAN     Q9GJ37_HUMAN     M9P9R6_HUMAN     D5FUG5_HUMAN     G1EN12_HUMAN     C9WEX4_HUMAN     H2A0A5_HUMAN     F0VRV6_HUMAN     F4YUB1_HUMAN     Q9GJM1_HUMAN     Q29744_HUMAN     M1VK07_HUMAN     L0HNF8_HUMAN     F4NBM1_HUMAN     A7UMH5_HUMAN     A7UP09_HUMAN     I6NVU2_HUMAN     F4NBL5_HUMAN     E2FZH3_HUMAN     F8SL10_HUMAN     M1L559_HUMAN     S0F2C9_HUMAN     Q29688_HUMAN     C8XTM1_HUMAN     I2CSG7_HUMAN     T1R361_HUMAN     M9PAI9_HUMAN     2B1E_HUMAN     C8XTK7_HUMAN     O77970_HUMAN     D7R0U4_HUMAN     R9WVY8_HUMAN     Q50EW5_HUMAN     C8XTJ0_HUMAN     Q8NEI3_HUMAN     H8WV90_HUMAN     O78044_HUMAN     F2X656_HUMAN     C8XTJ5_HUMAN     A8D9Z0_HUMAN     J7FK30_HUMAN     A7XPK7_HUMAN     Q6QJL9_HUMAN     M4YQI1_HUMAN     Q9UM38_HUMAN     F2VNV4_HUMAN     H2BDS2_HUMAN     G1EN09_HUMAN     D5G2J6_HUMAN     N1NSC4_HUMAN     F8R8M7_HUMAN     Q9BCN9_HUMAN     Q8WLU1_HUMAN     D0VE56_HUMAN     A0AQZ4_HUMAN     Q9TQ77_HUMAN     E7DVC3_HUMAN     D3JV18_HUMAN     F4YZX5_HUMAN     N1NVB1_HUMAN     C8CJD7_HUMAN     D5L9E8_HUMAN     G9FJH6_HUMAN     E0Z0A8_HUMAN     R4KZR5_HUMAN     D2SSL5_HUMAN     G8GB38_HUMAN     Q29725_HUMAN     D5FIE3_HUMAN     B2CKL1_HUMAN     L0BVK5_HUMAN     C3W973_HUMAN     M4QEN3_HUMAN     F8STB2_HUMAN     Q6QUQ1_HUMAN     C0LAB7_HUMAN     F4YUB0_HUMAN     H8WV95_HUMAN     A5I890_HUMAN     E1Y6P8_HUMAN     Q3LAB1_HUMAN     Q30178_HUMAN     Q30161_HUMAN     Q9TQ40_HUMAN     S0F2C4_HUMAN     B5D5S9_HUMAN     Q95HK9_HUMAN     F4NBL6_HUMAN     A4Q970_HUMAN     Q29786_HUMAN     J7K1E0_HUMAN     C8CBI3_HUMAN     S5UF48_HUMAN     D2D3G3_HUMAN     G1EMZ8_HUMAN     M9PAI8_HUMAN     M4MEW2_HUMAN     C8CJA7_HUMAN     D7RII0_HUMAN     U3PRP1_HUMAN     Q4U0U6_HUMAN     U5IQJ3_HUMAN     A1A413_HUMAN     G9HRN0_HUMAN     D7RIG2_HUMAN     H6SSQ5_HUMAN     F5BR67_HUMAN     C6L820_HUMAN     F4YZW9_HUMAN     E1U686_HUMAN     M9P9Q4_HUMAN     I6SJA4_HUMAN     M9P9Y9_HUMAN     C9WEX1_HUMAN     A0N0W0_HUMAN     C1KBK0_HUMAN     V6AQ63_HUMAN     Q6RCM2_HUMAN     F8R1E3_HUMAN     G1EMZ5_HUMAN     E9NVG8_HUMAN     J7K1D9_HUMAN     G1EN10_HUMAN     D7GK32_HUMAN     F2X662_HUMAN     U6BZR3_HUMAN     D2KZY2_HUMAN     G0WVD8_HUMAN     M9PNV3_HUMAN     I6M557_HUMAN     Q7JGS8_HUMAN     G9F9T7_HUMAN     Q9BCT6_HUMAN     F8R1E4_HUMAN     D5FID8_HUMAN     D7RIH0_HUMAN     F2X654_HUMAN     Q9BCS5_HUMAN     Q30008_HUMAN     B2ZCY0_HUMAN     D3KYL3_HUMAN     G8GB37_HUMAN     L0BXK6_HUMAN     F4NBL7_HUMAN     H8WV94_HUMAN     Q29692_HUMAN     Q45KF7_HUMAN     F2VP95_HUMAN     Q95IF1_HUMAN     J7K1E4_HUMAN     H8WV96_HUMAN     G1EMY8_HUMAN     D5FZP2_HUMAN     Q860C0_HUMAN     I0J8R2_HUMAN     G9HWB9_HUMAN     E1V2K2_HUMAN     H8WUJ3_HUMAN     F4NBM3_HUMAN     M9P8P7_HUMAN     N0AA59_HUMAN     D6BPR4_HUMAN     E9NVF8_HUMAN     M9P9B0_HUMAN     E1Y6P7_HUMAN     G5EM95_HUMAN     C9W8B4_HUMAN     R9WTI1_HUMAN     F1CCQ4_HUMAN     M9P8S8_HUMAN     H2BDT5_HUMAN     C8XTJ7_HUMAN     D6MJL3_HUMAN     S0F2C1_HUMAN     Q768U3_HUMAN     F8RHJ6_HUMAN     D2D3I3_HUMAN     A0AQY1_HUMAN     M9PAG9_HUMAN     D7RIG0_HUMAN     I1SB23_HUMAN     C6GZ76_HUMAN     V5J9Z3_HUMAN     E1V2J8_HUMAN     Q9MYD9_HUMAN     Q9BCN3_HUMAN     V9N3I1_HUMAN     U3PUP3_HUMAN     D9IFR0_HUMAN     D2D3H3_HUMAN     Q31644_HUMAN     I7CE35_HUMAN     R9WTI5_HUMAN     J7F697_HUMAN     Q9TQ78_HUMAN     B3GV29_HUMAN     E7D850_HUMAN     C0MQV9_HUMAN     Q7YQA2_HUMAN     H8WV77_HUMAN     Q8MGY3_HUMAN     M9P9Y5_HUMAN     F8RHN0_HUMAN     I6NVR2_HUMAN     F1CCN7_HUMAN     Q9GIX0_HUMAN     E3SWP3_HUMAN     B3V8R6_HUMAN     F2X657_HUMAN     M4VJ78_HUMAN     I6TN34_HUMAN     2B13_HUMAN     B1VJP6_HUMAN     S6B6T3_HUMAN     D6PZY9_HUMAN     C8XTM0_HUMAN     C7FDW8_HUMAN     F1CCQ0_HUMAN     Q7YPW3_HUMAN     E2D5U3_HUMAN     T2DPX1_HUMAN     F2X668_HUMAN     F8R8M6_HUMAN     Q702H0_HUMAN     H8WV82_HUMAN     E3SWP8_HUMAN     O19621_HUMAN     C4PFX4_HUMAN     M9P9Q8_HUMAN     D3U4E6_HUMAN     V9N2Y1_HUMAN     Q6S5I0_HUMAN     Q2LIR5_HUMAN     Q29649_HUMAN     Q860S8_HUMAN     J7K483_HUMAN     C6H0Y3_HUMAN     Q8SP68_HUMAN     Q5ID26_HUMAN     G8GB41_HUMAN     B1GVZ9_HUMAN     Q9GJG2_HUMAN     F4NBN6_HUMAN     D5FUG6_HUMAN     N1NUZ8_HUMAN     Q30195_HUMAN     C9DA77_HUMAN     D5FID2_HUMAN     Q3LAA5_HUMAN     B2RG89_HUMAN     Q95IT4_HUMAN     C7FDW7_HUMAN     Q3LTJ4_HUMAN     Q30105_HUMAN     F1AQS1_HUMAN     I7D962_HUMAN     S4T6L2_HUMAN     H8WV59_HUMAN     C9WEX7_HUMAN     Q6RCP7_HUMAN     Q2L4U2_HUMAN     D0VE58_HUMAN     Q56FN5_HUMAN     C8XTL4_HUMAN     Q53ZR8_HUMAN     D0VE51_HUMAN     M9PAI0_HUMAN     D7GN77_HUMAN     D7NPQ5_HUMAN     Q202I5_HUMAN     Q9TPB7_HUMAN     D9U3I1_HUMAN     F1CCP6_HUMAN     C8XTK5_HUMAN     A7UMH1_HUMAN     Q9TQ54_HUMAN     K7WK01_HUMAN     Q95IE4_HUMAN     D3JV13_HUMAN     H8WV67_HUMAN     D7RIH2_HUMAN     Q56FN4_HUMAN     C9WEX0_HUMAN     B9WPM8_HUMAN     S0F3J7_HUMAN     D6CJD7_HUMAN     S0F2D1_HUMAN     S0F3K2_HUMAN     Q95IE2_HUMAN     C9E1J3_HUMAN     Q7YQ32_HUMAN     S0F2C6_HUMAN     O62887_HUMAN     H9C8X6_HUMAN     Q860E1_HUMAN     B3VTQ4_HUMAN     Q9GIY6_HUMAN     E3SWR0_HUMAN     D5FZP6_HUMAN     Q19K81_HUMAN     G9HRM5_HUMAN     H8WV60_HUMAN     Q9TQ63_HUMAN     Q30130_HUMAN     E2D5U5_HUMAN     Q29736_HUMAN     F8SY60_HUMAN     Q19K84_HUMAN     O02951_HUMAN     E2GJN4_HUMAN     E2DHC1_HUMAN     F4NBM5_HUMAN     Q6UB42_HUMAN     A7X5F9_HUMAN     F8RHK1_HUMAN     M9P8N2_HUMAN     J7RFS4_HUMAN     S0F0E9_HUMAN     I7DEM0_HUMAN     V9N2U6_HUMAN     G1EMY5_HUMAN     Q7YQ27_HUMAN     F8RHK5_HUMAN     D6MJL1_HUMAN     H8WV98_HUMAN     E2DHC3_HUMAN     N1NTA9_HUMAN     M9P9E3_HUMAN     I6NN89_HUMAN     H9BSP6_HUMAN     Q3LAA9_HUMAN     C8C9V7_HUMAN     B2NJ39_HUMAN     Q9GIL4_HUMAN     B0RZ68_HUMAN     F2X653_HUMAN     Q30106_HUMAN     C0MP08_HUMAN     D2D3H7_HUMAN     V6BPA6_HUMAN     D7GN74_HUMAN     G0X8V1_HUMAN     B7U794_HUMAN     O19547_HUMAN     W1I8Y2_HUMAN     Q2PBC3_HUMAN     D5M8A1_HUMAN     C9WEW5_HUMAN     A0AQZ2_HUMAN     M9PA40_HUMAN     B2NJ33_HUMAN     J7F669_HUMAN     I7APH6_HUMAN     A7X5C9_HUMAN     F8SL06_HUMAN     B5A8Y7_HUMAN     U3PXU1_HUMAN     M9P9N4_HUMAN     D0EV56_HUMAN     U5IRI6_HUMAN     H6ULF5_HUMAN     F8RHL2_HUMAN     D2U823_HUMAN     O19586_HUMAN     N1NSB5_HUMAN     M9PA03_HUMAN     H2BDS5_HUMAN     G0WVE1_HUMAN     M9P8N4_HUMAN     M4MD18_HUMAN     C8CJD1_HUMAN     G1EMZ7_HUMAN     C7C5G1_HUMAN     D5M8A2_HUMAN     C8XTM7_HUMAN     Q8HWG3_HUMAN     Q4JH26_HUMAN     N1NTH4_HUMAN     F8STB1_HUMAN     C5NU45_HUMAN     Q45G73_HUMAN     B6DST2_HUMAN     Q29796_HUMAN     F1CCM2_HUMAN     Q9MY46_HUMAN     C9WEY3_HUMAN     Q3LTJ1_HUMAN     Q9TQ45_HUMAN     M9P9S3_HUMAN     Q0PGS7_HUMAN     E1V2K0_HUMAN     D2D3G5_HUMAN     Q4A1G9_HUMAN     Q9GJE9_HUMAN     C0LAC0_HUMAN     S0F3H9_HUMAN     A0T4C3_HUMAN     D5FID1_HUMAN     Q860I3_HUMAN     Q6DMR0_HUMAN     H6A2E8_HUMAN     D5FIE6_HUMAN     G9HRQ0_HUMAN     Q9MYC2_HUMAN     B3GDG8_HUMAN     E9NVH4_HUMAN     F2VP96_HUMAN     F4NBN8_HUMAN     Q95IF0_HUMAN     L8BTX7_HUMAN     Q9TQ61_HUMAN     G9I2P7_HUMAN     G0X8U8_HUMAN     F6KS30_HUMAN     M4MGI2_HUMAN     C9WEX2_HUMAN     Q860S7_HUMAN     G1EMZ2_HUMAN     D3UT98_HUMAN     H9AWW8_HUMAN     D3U4E9_HUMAN     A9YTA3_HUMAN     M9PA08_HUMAN     S5UF44_HUMAN     M4MFA7_HUMAN     E2DHB9_HUMAN     M1KN83_HUMAN     G9HRM6_HUMAN     C0LAB8_HUMAN     T1WFE7_HUMAN     C8C9V5_HUMAN     G8HT86_HUMAN     F2X650_HUMAN     D2EAF6_HUMAN     S4T758_HUMAN     C8XTL0_HUMAN     J7F4Z7_HUMAN     E7BYE1_HUMAN     D5FZP1_HUMAN     A8WDP0_HUMAN     F6KS28_HUMAN     J9PWN0_HUMAN     F8SL11_HUMAN     Q3LTK0_HUMAN     G0Z6Y8_HUMAN     Q860V5_HUMAN     C6L828_HUMAN     Q5NT90_HUMAN     D5FUG4_HUMAN     E1U687_HUMAN     F4NBL1_HUMAN     C9WEW3_HUMAN     D2D3H4_HUMAN     E9NVH3_HUMAN     Q8HWN4_HUMAN     Q70IU8_HUMAN     V9N379_HUMAN     U3PQT4_HUMAN     A5YP91_HUMAN     D5G249_HUMAN     Q95HK6_HUMAN     H2DML4_HUMAN     C9WEV4_HUMAN     Q3LAA3_HUMAN     B8YM95_HUMAN     C1JJS3_HUMAN     Q9BD26_HUMAN     C8XTK8_HUMAN     Q861H9_HUMAN     Q9Y4H8_HUMAN     S4T6T7_HUMAN     M9PAJ2_HUMAN     L0BXM6_HUMAN     G1EN04_HUMAN 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    C8XTK6_HUMAN     H8WV78_HUMAN     C8XTI7_HUMAN     Q861G4_HUMAN     A7UHG8_HUMAN     F8RHL8_HUMAN     A7UNZ9_HUMAN     F1CCP8_HUMAN     D3K479_HUMAN     C9WEV9_HUMAN     H8WV66_HUMAN     O19517_HUMAN     Q4PRC4_HUMAN     E1U685_HUMAN     E9NVH5_HUMAN     F1CCQ1_HUMAN     A7UNZ7_HUMAN     U6EFX2_HUMAN     C8CJD6_HUMAN     C7FDW5_HUMAN     B3KYW3_HUMAN     G8G268_HUMAN     Q3LTJ3_HUMAN     A8D305_HUMAN     B2NJ34_HUMAN     O19786_HUMAN     F4NBL3_HUMAN     O78037_HUMAN     D2D3I0_HUMAN     E5D6L7_HUMAN     M4MDE5_HUMAN     F2VPA3_HUMAN     C9E1J1_HUMAN     F2VNV9_HUMAN     C9WEW7_HUMAN     D7NP76_HUMAN     V5RNU3_HUMAN     G1DUW3_HUMAN     G1EMZ3_HUMAN     S0F3B8_HUMAN     D2D3H0_HUMAN     L0RH33_HUMAN     M9P9S5_HUMAN     F6KS24_HUMAN     E9NVH6_HUMAN     H2BDR6_HUMAN     F1CCN8_HUMAN     F8TVY1_HUMAN     Q861G5_HUMAN     M9PAI7_HUMAN     D0VE47_HUMAN     A8D9Y3_HUMAN     Q30109_HUMAN     C5J434_HUMAN     A8D9Z3_HUMAN     E3SGC9_HUMAN     Q30139_HUMAN     M9PA07_HUMAN     E3SWQ5_HUMAN     G0X8U7_HUMAN     D3Y5Y1_HUMAN     Q2A128_HUMAN     Q9BCS8_HUMAN     Q95HN0_HUMAN     G0WJF4_HUMAN     Q3LAB5_HUMAN     F2X661_HUMAN     C8XTI9_HUMAN     H8WV62_HUMAN     E9NVH1_HUMAN     E5RV91_HUMAN     G8GB40_HUMAN     G1EN17_HUMAN     H2BDS6_HUMAN     Q30111_HUMAN     Q4U4M6_HUMAN     L0BXQ5_HUMAN     D5M8A4_HUMAN     A8CKH4_HUMAN     C8C9V4_HUMAN     V5JA18_HUMAN     F8RHK8_HUMAN     A8KQQ2_HUMAN     I1V1W8_HUMAN     B3VTQ2_HUMAN     Q1G0Z7_HUMAN     F1CCM1_HUMAN     G0ZPP3_HUMAN     Q5IFG9_HUMAN     C8CJC9_HUMAN     F4NBN2_HUMAN     S0F3B7_HUMAN     Q30128_HUMAN     C8C9V9_HUMAN     C7FDW9_HUMAN     D5L9E7_HUMAN     D7GN76_HUMAN     B5A8Y5_HUMAN     A7UMH6_HUMAN     M9P9A5_HUMAN     H2BDS3_HUMAN     M9PNR5_HUMAN     W1I684_HUMAN     D9UC11_HUMAN     M9P9A8_HUMAN     B2RG88_HUMAN     D9U3H8_HUMAN     S0F2K9_HUMAN     C8XTK1_HUMAN     Q0R326_HUMAN     U6EFS4_HUMAN     Q8HWN3_HUMAN     K4Q1G1_HUMAN     S0F2C8_HUMAN     F4YUA6_HUMAN     C9WEX9_HUMAN     A7UP02_HUMAN     A0N9E2_HUMAN     J7GUA3_HUMAN     G9HRM3_HUMAN     D5G2K9_HUMAN     F8R1E8_HUMAN     E0X9M9_HUMAN     G9FJI0_HUMAN     F1CCM8_HUMAN     H8WV83_HUMAN     Q95IH1_HUMAN     F1CCM5_HUMAN     D5FIF1_HUMAN     Q860S2_HUMAN     M9PAH5_HUMAN     F6KS29_HUMAN     A4VAP8_HUMAN     F8RHJ1_HUMAN     D2D3H5_HUMAN     G4XPM1_HUMAN     M9P996_HUMAN     F4NBN4_HUMAN     Q29646_HUMAN     D6BPR3_HUMAN     B6ETP3_HUMAN     K7XHD2_HUMAN     K0P793_HUMAN     G5EM91_HUMAN     Q9TQ83_HUMAN     E3SWQ3_HUMAN     G0ZMN0_HUMAN     F8RHL3_HUMAN     D7RIG6_HUMAN     W0HE50_HUMAN     H6A2E7_HUMAN     G8HT88_HUMAN     Q6T714_HUMAN     Q9UEX9_HUMAN     M9P8Q1_HUMAN     D5L9E9_HUMAN     D3U4E3_HUMAN     B9WPM3_HUMAN     G1EMV6_HUMAN     D3JV17_HUMAN     N1NVA9_HUMAN     E5D6L8_HUMAN     Q861G3_HUMAN     B0F9M7_HUMAN     H8WV91_HUMAN     D6PZZ4_HUMAN     D2D3H1_HUMAN     W0NT93_HUMAN     L7UUQ7_HUMAN     S4T710_HUMAN     S0F3J9_HUMAN     F2VP98_HUMAN     Q0GB79_HUMAN     M9P982_HUMAN     G1EN20_HUMAN     F8SYK7_HUMAN     G9HRM8_HUMAN     G5EM93_HUMAN     D7GN79_HUMAN     I6MHJ7_HUMAN     E2GJP0_HUMAN     B3CL08_HUMAN     R9RSI5_HUMAN     D2D3H8_HUMAN     S5TRF0_HUMAN     E5RV95_HUMAN     A5HKN7_HUMAN     D7GK31_HUMAN     D0VE34_HUMAN     Q9TQ49_HUMAN     Q9TQ59_HUMAN     F8RHM5_HUMAN     M9P9P2_HUMAN     K7ZN81_HUMAN     A2VBX3_HUMAN     F8R8M3_HUMAN     E3SWR1_HUMAN     S0F3I7_HUMAN     N0A2S4_HUMAN     E0YTP3_HUMAN (see all proteins) (see all similar genes)(see first protein):
    HLA DRB4    HLA-DRB1*1301    HLA-DRB1*1302    HLA-DRB1*1402    HLA-DRB1*0402    HLA-DRB1*0407
    HLA-All    HLA-A null    HLA-A*03    HLA-DRB13    HLA-B27    HLA-DRB1*1605
    HLA-DRB1*1327    HLA-DRB14    HLA-Cw3    HLA-D8.2V    HLA-DRB4$0101    DRB52

    HLA-DRB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Polymorphic Variants from UniProtKB/Swiss-Prot
    2B11_HUMAN, P04229: The following alleles of DRB1-1 are known: DRB1*01:01; DRB1*01:02; DRB1*01:03; DRB1*01:04;
    DRB1*01:05; DRB1*01:06; DRB1*01:07; DRB1*01:08; DRB1*01:09; DRB1*01:10; DRB1*01:11; DRB1*01:12; DRB1*01:13;
    DRB1*01:14; DRB1*01:15; DRB1*01:16; DRB1*01:17; DRB1*01:18; DRB1*01:19; DRB1*01:20 and DRB1*01:21. The sequence
    shown is that of DRB1*01:01
    2B13_HUMAN, P01912: The following alleles of DRB1-3 are known: DRB1*03:01; DRB1*03:02; DRB1*03:03; DRB1*03:04;
    DRB1*03:05; DRB1*03:06; DRB1*03:07; DRB1*03:08; DRB1*03:09; DRB1*03:10; DRB1*03:11; DRB1*03:12; DRB1*03:13;
    DRB1*03:14; DRB1*03:15; DRB1*03:16; DRB1*03:17; DRB1*03:18; DRB1*03:19; DRB1*03:20; DRB1*03:21; DRB1*03:22;
    DRB1*03:23; DRB1*03:24; DRB1*03:25; DRB1*03:26; DRB1*03:27; DRB1*03:28; DRB1*03:29; DRB1*03:30; DRB1*03:31;
    DRB1*03:32; DRB1*03:33; DRB1*03:34; DRB1*03:35; DRB1*03:36; DRB1*03:37; DRB1*03:38; DRB1*03:39; DRB1*03:40 and
    DRB1*03:41. The sequence shown is that of DRB1*03:01
    2B14_HUMAN, P13760: The following alleles of DRB1-4 are known: DRB1*04:01, DRB1*04:02, DRB1*04:03, DRB1*04:04,
    DRB1*04:05, DRB1*04:06, DRB1*04:07, DRB1*04:08, DRB1*04:09, DRB1*04:10, DRB1*04:11, DRB1*04:12, DRB1*04:13,
    DRB1*04:14, DRB1*04:15, DRB1*04:16, DRB1*04:17, DRB1*04:18, DRB1*04:19, DRB1*04:20, DRB1*04:21, DRB1*04:22,
    DRB1*04:23, DRB1*04:24, DRB1*04:25, DRB1*04:26, DRB1*04:27, DRB1*04:28, DRB1*04:29, DRB1*04:30, DRB1*04:31,
    DRB1*04:32, DRB1*04:33, DRB1*04:34, DRB1*04:35, DRB1*04:36, DRB1*04:37, DRB1*04:38, DRB1*04:39, DRB1*04:40,
    DRB1*04:41, DRB1*04:42, DRB1*04:43, DRB1*04:44, DRB1*04:45, DRB1*04:46, DRB1*04:47, DRB1*04:48, DRB1*04:49,
    DRB1*04:50, DRB1*04:51, DRB1*04:52, DRB1*04:53, DRB1*04:54, DRB1*04:55, DRB1*04:56, DRB1*04:57, DRB1*04:58,
    DRB1*04:59, DRB1*04:60, DRB1*04:61, DRB1*04:62, DRB1*04:63, DRB1*04:64, DRB1*04:65, DRB1*04:66, DRB1*04:67,
    DRB1*04:68, DRB1*04:69, DRB1*04:70, DRB1*04:71, DRB1*04:72, DRB1*04:73, DRB1*04:74, DRB1*04:75, DRB1*04:76,
    DRB1*04:77 and DRB1*04:78. The sequence shown is that of DRB1*04:01
    2B17_HUMAN, P13761: The following alleles of DRB1-7 are known: DRB1*07:01, DRB1*07:03, DRB1*07:04, DRB1*07:05,
    DRB1*07:06, DRB1*07:07, DRB1*07:08, DRB1*07:09, DRB1*07:11, DRB1*07:12, DRB1*07:13, DRB1*07:14, DRB1*07:15,
    DRB1*07:16 and DRB1*07:17. The sequence shown is that of DRB1*07:01
    2B17_HUMAN, P13761: Allele DRB1*07:01 is associated with persistent hepatitis C virus (HCV) infections [MIM:609532]
    2B18_HUMAN, Q30134: The following alleles of DRB1-8 are known: DRB1*08:01 (Dw8.1), DRB1*08:02 (Dw8.2; DRB1L), DRB1*08:03
    (Dw8.3); DRB1*08:04; DRB1*08:05, DRB1*08:06, DRB1*08:07, DRB1*08:08, DRB1*08:09, DRB1*08:10, DRB1*08:11,
    DRB1*08:12, DRB1*08:13, DRB1*08:14, DRB1*08:15, DRB1*08:16, DRB1*08:17, DRB1*08:18, DRB1*08:19, DRB1*08:20,
    DRB1*08:21, DRB1*08:22, DRB1*08:23, DRB1*08:24, DRB1*08:25, DRB1*08:26, DRB1*08:27, DRB1*08:28, DRB1*08:29,
    DRB1*08:30, DRB1*08:31, DRB1*08:32, DRB1*08:33, DRB1*08:34, DRB1*08:35 and DRB1*08:36. The sequence shown is that
    of DRB1*08:01
    2B19_HUMAN, Q9TQE0: The following alleles of DRB1-9 are known: DRB1*09:01, DRB1*09:02, DRB1*09:03, DRB1*09:04,
    DRB1*09:05, DRB1*09:06, DRB1*09:07 and DRB1*09:08. The sequence shown is that of DRB1*09:01
    2B1A_HUMAN, Q30167: The following alleles of DRB1-10 are known: DRB1*10:01; DRB1*10:02 and DRB1*10:03. The sequence
    shown is that of DRB1*10:01
    2B1B_HUMAN, P20039: The following alleles of DRB1-11 are known: DRB1*11:01, DRB1*11:03, DRB1*11:04, DRB1*11:05,
    DRB1*11:06, DRB1*11:07, DRB1*11:08, DRB1*11:09, DRB1*11:10, DRB1*11:11, DRB1*11:12, DRB1*11:13, DRB1*11:14,
    DRB1*11:15, DRB1*11:16, DRB1*11:17, DRB1*11:18, DRB1*11:19, DRB1*11:20, DRB1*11:21, DRB1*11:22, DRB1*11:23,
    DRB1*11:24, DRB1*11:25, DRB1*11:26, DRB1*11:27, DRB1*11:28, DRB1*11:29, DRB1*11:30, DRB1*11:31, DRB1*11:32,
    DRB1*11:33, DRB1*11:34, DRB1*11:35, DRB1*11:36, DRB1*11:37, DRB1*11:38, DRB1*11:39, DRB1*11:40, DRB1*11:41,
    DRB1*11:42, DRB1*11:43, DRB1*11:44, DRB1*11:45, DRB1*11:46, DRB1*11:47, DRB1*11:48, DRB1*11:49, DRB1*11:50,
    DRB1*11:51, DRB1*11:52, DRB1*11:53, DRB1*11:54, DRB1*11:55, DRB1*11:56, DRB1*11:57, DRB1*11:58, DRB1*11:59,
    DRB1*11:60, DRB1*11:61, DRB1*11:62, DRB1*11:63, DRB1*11:64, DRB1*11:65, DRB1*11:66, DRB1*11:67, DRB1*11:68,
    DRB1*11:69, DRB1*11:70 and DRB1*11:72. The sequence shown is that of DRB1*11:01
    2B1B_HUMAN, P20039: Allele DRB1*11:01 is associated with self-limiting hepatitis C virus (HCV) infections [MIM:609532]
    2B1C_HUMAN, Q95IE3: The following alleles of DRB1-12 are known: DRB1*12:01, DRB1*12:02, DRB1*12:03, DRB1*12:04,
    DRB1*12:05, DRB1*12:06, DRB1*12:07, DRB1*12:08, DRB1*12:09, DRB1*12:10, DRB1*12:11, DRB1*12:12, DRB1*12:13,
    DRB1*12:14, DRB1*12:15, DRB1*12:16, DRB1*12:17, DRB1*12:18 and DRB1*12:19. The sequence shown is that of
    DRB1*12:01
    2B1D_HUMAN, Q5Y7A7: The following alleles of DRB1-13 are known: DRB1*13:01, DRB1*13:02, DRB1*13:03, DRB1*13:04,
    DRB1*13:05, DRB1*13:06, DRB1*13:07, DRB1*13:08, DRB1*13:09, DRB1*13:10, DRB1*13:11, DRB1*13:12, DRB1*13:13,
    DRB1*13:14, DRB1*13:15, DRB1*13:16, DRB1*13:17, DRB1*13:18, DRB1*13:19, DRB1*13:20, DRB1*13:21, DRB1*13:22,
    DRB1*13:23, DRB1*13:24, DRB1*13:25, DRB1*13:26, DRB1*13:27, DRB1*13:28, DRB1*13:29, DRB1*13:30, DRB1*13:31,
    DRB1*13:32, DRB1*13:33, DRB1*13:34, DRB1*13:35, DRB1*13:36, DRB1*13:37, DRB1*13:38, DRB1*13:39, DRB1*13:40,
    DRB1*13:41, DRB1*13:42, DRB1*13:43, DRB1*13:44, DRB1*13:45, DRB1*13:46, DRB1*13:47, DRB1*13:48, DRB1*13:49,
    DRB1*13:50, DRB1*13:51, DRB1*13:52, DRB1*13:53, DRB1*13:54, DRB1*13:55, DRB1*13:56, DRB1*13:57, DRB1*13:58,
    DRB1*13:59, DRB1*13:60, DRB1*13:61, DRB1*13:62, DRB1*13:63, DRB1*13:64, DRB1*13:65, DRB1*13:66, DRB1*13:67,
    DRB1*13:68, DRB1*13:69, DRB1*13:70, DRB1*13:71, DRB1*13:72, DRB1*13:73, DRB1*13:74, DRB1*13:75, DRB1*13:76,
    DRB1*13:77, DRB1*13:78, DRB1*13:79, DRB1*13:80, DRB1*13:81, DRB1*13:82, DRB1*13:83, DRB1*13:84, DRB1*13:85,
    DRB1*13:86, DRB1*13:87 and DRB1*13:88. The sequence shown is that of DRB1*13:01
    2B1E_HUMAN, Q9GIY3: The following alleles of DRB1-14 are known: DRB1*14:01, DRB1*14:02, DRB1*14:03, DRB1*14:04,
    DRB1*14:05, DRB1*14:06, DRB1*14:07, DRB1*14:08, DRB1*14:09, DRB1*14:10, DRB1*14:11, DRB1*14:12, DRB1*14:13,
    DRB1*14:14, DRB1*14:15, DRB1*14:16, DRB1*14:17, DRB1*14:18, DRB1*14:19, DRB1*14:20, DRB1*14:21, DRB1*14:22,
    DRB1*14:23, DRB1*14:24, DRB1*14:25, DRB1*14:26, DRB1*14:27, DRB1*14:28, DRB1*14:29, DRB1*14:30, DRB1*14:31,
    DRB1*14:32, DRB1*14:33, DRB1*14:34, DRB1*14:35, DRB1*14:36, DRB1*14:37, DRB1*14:38, DRB1*14:39, DRB1*14:40,
    DRB1*14:41, DRB1*14:42, DRB1*14:43, DRB1*14:44, DRB1*14:45, DRB1*14:46, DRB1*14:47, DRB1*14:48, DRB1*14:49,
    DRB1*14:50, DRB1*14:51, DRB1*14:52, DRB1*14:53, DRB1*14:54, DRB1*14:55, DRB1*14:56, DRB1*14:57, DRB1*14:58,
    DRB1*14:59, DRB1*14:60, DRB1*14:61, DRB1*14:62, DRB1*14:63, DRB1*14:64, DRB1*14:65, DRB1*14:67, DRB1*14:68,
    DRB1*14:69, DRB1*14:70, DRB1*14:71, DRB1*14:72, DRB1*14:73, DRB1*14:74, DRB1*14:75, DRB1*14:76, DRB1*14:77,
    DRB1*14:78, DRB1*14:79, DRB1*14:80, DRB1*14:81, DRB1*14:82, DRB1*14:83, DRB1*14:84 and DRB1*14:85. The sequence
    shown is that of DRB1*14:01
    2B1F_HUMAN, P01911: The following alleles of DRB1-15 are known: DRB1*15:01, DRB1*15:02, DRB1*15:03, DRB1*15:04,
    DRB1*15:05, DRB1*15:06, DRB1*15:07, DRB1*15:08, DRB1*15:09, DRB1*15:10, DRB1*15:11, DRB1*15:12, DRB1*15:13,
    DRB1*15:14, DRB1*15:15, DRB1*15:16, DRB1*15:18, DRB1*15:19, DRB1*15:20, DRB1*15:21, DRB1*15:22, DRB1*15:23,
    DRB1*15:24, DRB1*15:25, DRB1*15:26, DRB1*15:27, DRB1*15:28, DRB1*15:29, DRB1*15:30, DRB1*15:31 and DRB1*15:32.
    The sequence shown is that of DRB1*15:01
    2B1G_HUMAN, Q29974: The following alleles of DRB1-16 are known: DRB1*16:01; DRB1*16:02; DRB1*16:03; DRB1*16:04;
    DRB1*16:05; DRB1*16:07; DRB1*16:08; DRB1*16:09; DRB1*16:10; DRB1*16:11 and DRB1*16:12. The sequence shown is that
    of DRB1*16:02


    Selected SNPs for HLA-DRB1 (see all 1470)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs719457571,2
    C--32546054(+) CTCTC-/AGAT  
            
    AGAAC
    3 -- ds50010--------
    rs412871501,2
    C--32546056(+) CTCAGA/GTAGAA 3 -- ds50014Minor allele frequency- G:0.30WA NA EA 360
    rs343302471,2
    C--32546057(+) TCAGA-/T/TAGA
            
    GAACA
    1 -- ds50010--------
    rs92696481,2
    C--32546060(+) GATAGC/AACATA 3 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs92696491,2
    C--32546067(+) CATAAT/CGGAGA 3 -- ds50011Minor allele frequency- C:0.00NA 2
    rs92696501,2
    C--32546068(+) ATAACG/AGAGAA 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs339255761,2
    C--32546073(+) GAGAA-/CTCC  
            
    CTCTC
    1 -- ds50010--------
    rs92696511,2
    C,F--32546074(+) GAGAAC/TTCTCC 1 -- ds50012Minor allele frequency- T:0.38NA MN 8
    rs92696521,2
    C,F--32546075(+) AGAACC/TCTCCA 1 -- ds50011Minor allele frequency- T:0.50MN 6
    rs356893431,2
    C--32546079(+) CTCTCC/TATCTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for HLA-DRB1 (32546546 - 32557625 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HLA-DRB1 (see all 91):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731847CNV Deletion23290073
    dgv1100e199CNV Deletion23128226
    esv2731848CNV Deletion23290073
    dgv1106e199CNV Deletion23128226
    dgv1108e199CNV Deletion23128226
    dgv1105e199CNV Deletion23128226
    esv2422111CNV Deletion20811451
    dgv1045e201CNV Deletion23290073
    esv2421657CNV Deletion20811451
    esv1128844CNV Insertion17803354

    Human Gene Mutation Database (HGMD): HLA-DRB1
    Locus Specific Mutation Databases (LSDB): HLA-DRB1

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HLA-DRB1
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-DRB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142857   
    OMIM disorders: 181000  126200  180300  
    UniProtKB/Swiss-Prot: 2B1G_HUMAN, Q29974
  • Sarcoidosis 1 (SS1) [MIM:181000]: An idiopathic, systemic, inflammatory disease characterized by the
    formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic
    system, but also skin, liver, spleen, eyes and other organs may be involved. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • Selected diseases for HLA-DRB1 (see all 378):    About MalaCards
    bullous pemphigoid    rhizomelic pseudopolyarthritis    sarcoidosis 1    limited scleroderma
    pediatric systemic sclerosis    diffuse scleroderma    multiple sclerosis 1    rheumatoid arthritis
    narcolepsy    actinic prurigo    postherpetic neuralgia    halo nevi
    vogt-koyanagi-harada disease    pars planitis    kleine-levin syndrome    tubulointerstitial nephritis and uveitis
    focal epithelial hyperplasia    c4a deficiency    narcolepsy 1    small fiber neuropathy

    9 diseases from the University of Copenhagen DISEASES database for HLA-DRB1:
    Hypersensitivity reaction type II disease     Rheumatoid arthritis     Diabetes mellitus     Hyperthyroidism
    Connective tissue disease     Thyroiditis     Skin disease     Leprosy
    Multiple sclerosis

    HLA-DRB1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for HLA-DRB1 gene (see all 53)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 66.3 64 1416553 (3), 16277691 (2), 16385499 (2), 10765919 (2) (see all 44)
    genetic susceptibility 65.2 8 17055211 (1), 17047287 (1), 17309132 (1), 18004301 (1) (see all 8)
    polymyalgia rheumatica 58.1 10 10225816 (2), 8147928 (2), 9458210 (2), 15305244 (2) (see all 5)
    diabetes mellitus insulin-dependent 50.2 2 10680451 (1), 7817375 (1)
    autoimmune diseases 49.3 5 16362107 (1), 19117368 (1), 16198136 (1), 1617108 (1) (see all 5)
    vogt-koyanagi-harada disease 46.6 2 7906684 (1), 15603876 (1)
    autoimmunity 44.1 4 16385499 (1), 17987563 (1), 15120192 (1), 8675578 (1)
    hepatitis autoimmune 44 3 1350267 (2), 9672174 (1)
    pemphigus foliaceus 36.9 1 9027963 (1)
    diabetes autoimmune 35.6 2 10333055 (1), 18279373 (1)

    Genetic Association Database (GAD): HLA-DRB1
    Human Genome Epidemiology (HuGE) Navigator: HLA-DRB1 (1845 documents)

    Export disorders for HLA-DRB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HLA-DRB1 gene, integrated from 10 sources (see all 2629):
    (articles sorted by number of sources associating them with HLA-DRB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. [Determination of HLA-DRB1 gene polymorphism in Luoba ethnic group of Tibet]. (PubMed id 15898419)1, 4, 9 Kang L.L....Li S.B. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2005)
    2. Influence of HLA-DRB1 and TNF microsatellite polymorphisms on the expression of extraarticular manifestations in rheumatoid arthritis patients from northwest Spain. (PubMed id 11791643)1, 4, 9 Mattey D.L....Ollier W.E. (Clin. Exp. Rheumatol. 2001)
    3. Genetic variations of HLA-DRB1 and susceptibility to Kawasaki disease in Taiwanese children. (PubMed id 17207714)1, 4, 9 Huang F.Y....Lee Y.J. (Hum. Immunol. 2007)
    4. Pro-inflammatory variants of DRB1 and RAGE genes are associated with susceptibility to pediatric type 1 diabetes: a new hypothesis on the adaptive role of autoimmunity. (PubMed id 17987563)1, 4, 9 Damiani G....Cuccia M. (Riv. Biol. 2007)
    5. [Possible association between HLA-HRB1 and DQB1 genes frequency and susceptibility or resistance to Helicobacter pylori infection in Kunming Yi ethnic group children]. (PubMed id 15833172)1, 4, 9 Huang Y.K....Zhou L.F. (Zhonghua Er Ke Za Zhi 2005)
    6. HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China. (PubMed id 14570623)1, 4, 9 Li F....Craig P.S. (Chin. Med. J. 2003)
    7. The effect of HLA-DRB1 genes, rheumatoid factor, and treatment on radiographic disease progression in rheumatoid arthritis over 6 years. (PubMed id 11093435)1, 4, 9 Rau R....Fenner H. (J. Rheumatol. 2000)
    8. Role of HLA-DRB1 and PTPN22 genes in susceptibility to juvenile idiopathic arthritis in Hungarian patients. (PubMed id 19210888)1, 4, 9 PazA!r B....PoA^r G. (Clin. Exp. Rheumatol. 2008)
    9. [Gene and haplotype frequencies for the loci HLA-A, B and DRB1 in 11755 north Chinese Han bone marrow registry donors]. (PubMed id 17493347)1, 4, 9 Wu Q.J....Wei X.Q. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2007)
    10. [Polymorphism of human leukocyte antigen-A, B, and DRB1 genes in bone marrow registry donors of Shaanxi province analysis of 14 006 cases]. (PubMed id 17288808)1, 4, 9 Liu M.L....Liu S. (Zhonghua Yi Xue Za Zhi 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3123 HGNC: 4948 AceView: HLA-DRB1.1 Ensembl:ENSG00000196126 euGenes: HUgn3123
    ECgene: HLA-DRB1 Kegg: 3123 H-InvDB: HLA-DRB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HLA-DRB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HLA-DRB1 gene:
    Search GeneIP for patents involving HLA-DRB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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