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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLA-DRB1 Gene

protein-coding   GIFtS: 63
GCID: GC06M032546

major histocompatibility complex, class II, DR beta 1


(Previous symbol: HLA-DR1B)
 Explore 358 diseases affiliated with
HLA-DRB1 via
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Biological research products
for HLA-DRB1    

Aliases
for HLA-DRB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Major Histocompatibility Complex, Class II, DR Beta 11 2     DR133
HLA-DR1B1 2 5     DR143
DRw102 3     DR163
DW2.2/DR2.22 3     DR43
SS12 5     DR53
DRB12     DR73
HLA-DRB2     DR83
HLA Class II Histocompatibility Antigen, DR-1 Beta Chain2     DR93
Human Leucocyte Antigen DRB12     DRw113
Lymphocyte Antigen DRB12     DRw83
MHC Class II Antigen2     HLA-DRB23
MHC Class II HLA-DR Beta 1 Chain2     Clone P2-Beta-33
MHC Class II HLA-DR-Beta Cell Surface Glycoprotein2     MHC Class II Antigen DRB1*13
MHC Class II HLA-DRw10-Beta2     MHC Class II Antigen DRB1*103
DR-13     MHC Class II Antigen DRB1*113
DR-123     MHC Class II Antigen DRB1*123
DR-133     MHC Class II Antigen DRB1*133
DR-143     MHC Class II Antigen DRB1*143
DR-163     MHC Class II Antigen DRB1*153
DR-43     MHC Class II Antigen DRB1*163
DR-53     MHC Class II Antigen DRB1*33
DR-73     MHC Class II Antigen DRB1*43
DR-83     MHC Class II Antigen DRB1*73
DR-93     MHC Class II Antigen DRB1*83
DR13     MHC Class II Antigen DRB1*93
DR123     

External Ids:    HGNC: 49481   Entrez Gene: 31232   Ensembl: ENSG000001961267   OMIM: 1428575   UniProtKB: P042293   
UniProtKB: P019123   UniProtKB: P137603   UniProtKB: P137613   UniProtKB: Q301343   UniProtKB: Q9TQE03   
UniProtKB: Q301673   UniProtKB: P200393   UniProtKB: Q95IE33   UniProtKB: Q5Y7A73   UniProtKB: Q9GIY33   
UniProtKB: P019113   UniProtKB: Q299743   

Export aliases for HLA-DRB1 gene to outside databases

Previous GC identifers: GC06U990049 GC06Md32547 GC06M032317 GC06Md32654 GC06M032656


Summaries
for HLA-DRB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HLA-DRB1:
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha
(DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by
presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells
(APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6
exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the
transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the
polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing
for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level
five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1
are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6,
DRB7, DRB8 and DRB9. (provided by RefSeq, Jul 2008)

UniProtKB/ace: 2B11_HUMAN, P04229 (see all)
Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and
presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides
of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins
that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous
antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and
for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their
way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal
compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a
source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition
to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74
and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an
antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the
ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen
processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a
small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM
via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules
until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported
to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by
HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the
regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
efficient peptide loading

Gene Wiki entry for HLA-DRB1


Genomic Views
for HLA-DRB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NT_113891.2  NT_167248.1  NC_000006.11  NC_018917.1  NT_007592.15  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLA-DRB1 gene promoter:
         HOXA3   AML1a   p53   CUTL1   CBF-C   YY1   CBF-B   CBF-A   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HLA-DRB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HLA-DRB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DRB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

HLA-DRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-DRB1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032546:  view genomic region     (about GC identifiers)

Start:
 32,546,546 bp from pter      End:
 32,557,625 bp from pter
Size:
 11,080 bases      Orientation:
 minus strand

2 alternative locations:
Chr6-,ALT_REF_LOCI_2 32,475,947-32,528,486      Chr6-,ALT_REF_LOCI_7 32,510,207-32,722,298     

Proteins
for HLA-DRB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: 2B11_HUMAN, P04229 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen, DRB1-1 beta chain precursor  
Size: 266 amino acids; 29914 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
6/39 PDB 3D structures from and Proteopedia for HLA-DRB1 (see all 39):
1AQD (3D)        1DLH (3D)        1FYT (3D)        1HXY (3D)        1JWM (3D)        1JWS (3D)    
Secondary accessions: A4F5N0 A8K098 O62869 P13758 Q06662 Q30116 Q30117 Q5Y7E9 Q7M2H4 Q95461 Q9BCL7
Q9GIK5 Q9MXZ0 Q9MXZ5 Q9TQ91

UniProtKB/Swiss-Prot: 2B13_HUMAN, P01912 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-3 chain precursor  
Size: 266 amino acids; 30120 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
1 PDB 3D structure from and Proteopedia for HLA-DRB1:
1A6A (3D)    

UniProtKB/Swiss-Prot: 2B14_HUMAN, P13760 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-4 beta chain precursor  
Size: 266 amino acids; 30112 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
6/8 PDB 3D structures from and Proteopedia for HLA-DRB1 (see all 8):
1D5M (3D)        1D5X (3D)        1D5Z (3D)        1D6E (3D)        1J8H (3D)        2SEB (3D)    
Secondary accessions: O19717 O19739 P13759 Q29875 Q30145 Q9GIX9 Q9GIY4 Q9MY13 Q9XRY5

UniProtKB/Swiss-Prot: 2B17_HUMAN, P13761 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-7 beta chain precursor  
Size: 266 amino acids; 29822 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Secondary accessions: B0UYW1 O46699 O46872

UniProtKB/Swiss-Prot: 2B18_HUMAN, Q30134 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-8 beta chain precursor  
Size: 266 amino acids; 30004 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Secondary accessions: O19718 O19788 Q29968 Q30108 Q30115 Q9BCP0 Q9BCP1 Q9BCP2 Q9BD33 Q9TQ37 Q9UIM9

UniProtKB/Swiss-Prot: 2B19_HUMAN, Q9TQE0 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-9 beta chain precursor  
Size: 266 amino acids; 29826 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Secondary accessions: Q30149

UniProtKB/Swiss-Prot: 2B1A_HUMAN, Q30167 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-10 beta chain precursor  
Size: 266 amino acids; 30002 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Secondary accessions: P01914 Q9MYF5

UniProtKB/Swiss-Prot: 2B1B_HUMAN, P20039 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-11 beta chain precursor  
Size: 266 amino acids; 30160 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Secondary accessions: Q30006 Q9GIX8

UniProtKB/Swiss-Prot: 2B1C_HUMAN, Q95IE3 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-12 beta chain precursor  
Size: 266 amino acids; 29878 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Secondary accessions: A7LA26 B0LUZ6 B6VCX2 B7UDB2 O19585 Q19AF2 Q29771 Q2L9H4 Q2MZ92 Q5EER6 Q5NDB9
Q5UT58 Q5Y7G0 Q768U4 Q7YP04 Q861H8 Q95IT6 Q9BD40

UniProtKB/Swiss-Prot: 2B1D_HUMAN, Q5Y7A7 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-13 beta chain precursor  
Size: 266 amino acids; 30008 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Sequence caution: Sequence=CAB40418.1; Type=Erroneous gene model prediction;
Secondary accessions: A0MWF2 A2ICT1 A4ZXA5 A4ZXA6 A7UHG2 A7X5K7 A8YQE9 B0BK85 B3VTQ3 B5A8Y2 B5A8Y3
B5B9V6 B5QSK8 C0LAB5 O02930 O62889 O78047 P79545 Q14280 Q14QT2 Q19K86 Q1G0Z9 Q1KLJ6 Q29673 Q29720
Q29722 Q29806 Q29833 Q29874 Q29886 Q2MF40 Q2YHQ2 Q30112 Q3LA93 Q3LA94 Q3LA95 Q3LA96 Q3LA97 Q3LA98
Q3LA99 Q3LAA0 Q3LAA1 Q3LAA2 Q3MQ60 Q53IG1 Q56FP2 Q56FP3 Q58F52 Q5K3W2 Q5UBA2 Q5W3L4 Q6REE2 Q6U387
Q701T1 Q70Q85 Q768U2 Q7YP03 Q7YQ26 Q7YQA3 Q860E5 Q860H8 Q860Z3 Q861G6 Q861H0 Q861H4 Q8HWQ6 Q8WMA0
Q95389 Q95HL1 Q96HZ9 Q9BCP5 Q9BD21 Q9GIP3 Q9GJ25 Q9GJ60 Q9GJF8 Q9GJF9 Q9GJG0 Q9MY45 Q9MY56 Q9TPW3
Q9TPW9 Q9TPX4 Q9UBY1 Q9UIN0 Q9XRX1 Q9Y453

UniProtKB/Swiss-Prot: 2B1E_HUMAN, Q9GIY3 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-14 beta chain precursor  
Size: 266 amino acids; 30139 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Sequence caution: Sequence=CAB45249.1; Type=Erroneous gene model prediction;
Secondary accessions: A0N0W1 A2TGX3 A4ZY86 A5H000 A5HKN8 A7DZP9 A7X5B1 A7X5B7 A7X5E0 A7X5E6 A7X5H8
A9JPG0 B1GWE7 B2CR03 B2LVF9 B2NJ29 B2ZCY1 B3VTP8 B5B8U0 B5B9V5 B5LZ25 B6VEL9 B9VRA4 B9X248 O02876
O46793 O77969 O78210 Q0PQ39 Q155F7 Q1AP33 Q1JRP3 Q27PR6 Q27PR7 Q29734 Q29770 Q29772 Q29800 Q2A120
Q2HZE5 Q2LE76 Q2MJA6 Q2VQU1 Q307W5 Q31636 Q3LA87 Q3LA88 Q3LA89 Q3LA90 Q3LA91 Q3LA92 Q3T919 Q4PRC3
Q4PRC5 Q4VZY7 Q56FP1 Q5BM92 Q5U9W6 Q683P7 Q70GL2 Q7YNY9 Q7YQA5 Q860D8 Q860D9 Q860S0 Q861H5 Q861H7
Q8MH59 Q8MH60 Q8WLU3 Q95348 Q95HK1 Q95HL0 Q95IG2 Q9GIL5 Q9GIL6 Q9GIY0 Q9GIY1 Q9GIY2 Q9GJ56 Q9GJ57
Q9GJ58 Q9TPB6 Q9TPW1 Q9XRY4 Q9Y4H7

UniProtKB/Swiss-Prot: 2B1F_HUMAN, P01911 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-15 beta chain precursor  
Size: 266 amino acids; 29966 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Miscellaneous: The chain shown constituted about 70% of a pool of at least seven similar beta chains
3 PDB 3D structures from and Proteopedia for HLA-DRB1:
1BX2 (3D)        1YMM (3D)        2WBJ (3D)    
Secondary accessions: Q29790 Q29975 Q30142 Q30166 Q32MY7 Q56FN9 Q5Y7B0 Q5Y7B9

UniProtKB/Swiss-Prot: 2B1G_HUMAN, Q29974 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-16 beta chain precursor  
Size: 266 amino acids; 30030 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant
chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes
sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC
class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of
antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass
type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome
membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome
membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of
intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation
Secondary accessions: A7X5J4 O98212 Q0PGR5 Q29792 Q30120 Q30159 Q30200 Q3HUP9 Q3KTM1 Q3LA84 Q6T865
Q95383

Explore the universe of human proteins at neXtProt for HLA-DRB1: NX_Q29974

Post-translational modifications:

  • Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of MHC
    • class II (Probable)1
  • View modification sites using PhosphoSitePlus2 (HLA-DRB4)
  • View neXtProt modification sites for NX_Q29974

    • HLA-DRB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230894.1  NP_002115.2  

    ENSEMBL proteins: 
     ENSP00000353099  
    Reactome Protein details: Q30167 Q5Y7A7 P04229 Q9TQE0 Q9GIY3 P01911 Q29974 P20039 Q95IE3 P01912 P13760 Q30134 P13761
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: HLA-DRB1
    OriGene Protein Over-expression Lysate: HLA-DRB1
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    Novus Biologicals HLA-DRB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HLA-DRB1

    Gene Ontology (GO): 5/17 cellular component terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005765lysosomal membrane TAS--
    GO:0005789endoplasmic reticulum membrane ----
    GO:0005794Golgi apparatus ----
    GO:0005886plasma membrane TAS--


    HLA-DRB1 for ontologies           About GeneDecksing



    HLA-DRB1 Antibody Products: 
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    Uscn ELISAs and CLIAs for HLA-DRB1

    Protein Domains /
    Families
    for HLA-DRB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HLA-DRB1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR000353 MHC_II_b_N
     IPR013783 Ig-like_fold
     IPR014745 MHC_II_a/b_N
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry P04229
    Graphical View of Domain Structure for InterPro Entry P01912
    Graphical View of Domain Structure for InterPro Entry P13760
    Graphical View of Domain Structure for InterPro Entry P13761
    Graphical View of Domain Structure for InterPro Entry Q30134
    Graphical View of Domain Structure for InterPro Entry Q9TQE0
    Graphical View of Domain Structure for InterPro Entry Q30167
    Graphical View of Domain Structure for InterPro Entry P20039
    Graphical View of Domain Structure for InterPro Entry Q95IE3
    Graphical View of Domain Structure for InterPro Entry Q5Y7A7
    Graphical View of Domain Structure for InterPro Entry Q9GIY3
    Graphical View of Domain Structure for InterPro Entry P01911
    Graphical View of Domain Structure for InterPro Entry Q29974

    ProtoNet protein and cluster: P04229

    2 Blocks protein families:
    IPB000353 Class II histocompatibility antigen
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: 2B11_HUMAN, P04229
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B13_HUMAN, P01912
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B14_HUMAN, P13760
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B17_HUMAN, P13761
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B18_HUMAN, Q30134
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B19_HUMAN, Q9TQE0
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1A_HUMAN, Q30167
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1B_HUMAN, P20039
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1C_HUMAN, Q95IE3
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1D_HUMAN, Q5Y7A7
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1E_HUMAN, Q9GIY3
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1F_HUMAN, P01911
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1G_HUMAN, Q29974
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Function
    for HLA-DRB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:
    UniProtKB/ace: 2B11_HUMAN, P04229 (see all)
    Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and
    presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides
    of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins
    that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous
    antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and
    for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their
    way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal
    compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a
    source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition
    to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74
    and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an
    antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the
    ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen
    processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a
    small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM
    via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules
    until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported
    to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by
    HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the
    regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
    efficient peptide loading

         Genatlas biochemistry entry for HLA-DRB1:
    HLA-DR,beta 1 chain,determining DR1,3,4,5 etc

    miRNA
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    Inhib. RNA
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HLA-DRB1

    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032395MHC class II receptor activity TAS3456344
    GO:0042605peptide antigen binding ISS--


    HLA-DRB1 for ontologies           About GeneDecksing



    Pathways & Interactions
    for HLA-DRB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/34 super-pathways (see all 34) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transport of MHC II:Ii complex along Golgi to TGN
    		Transport of MHC II:Ii complex to plasma membrane1.00
    		Trafficking of nonameric complex in the endocytic pathway1.00
    		Transport of MHC II:Ii complex along Golgi to TGN1.00
    		Internalization of MHC II:Ii clathrin coated vesicle0.52
    		Insertion of MHC II:Ii complex in to the plasma membrane1.00
    2Translocation of ZAP-70 to Immunological synapse
    		Translocation of ZAP-70 to Immunological synapse1.00
    		PD-1 signaling0.76
    		Phosphorylation of CD3 and TCR zeta chains0.85
    		Generation of second messenger molecules0.64
    3Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    4Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    5Interferon gamma signaling
    		Interferon gamma signaling1.00
    		Expression of IFNG-stimulated genes0.72

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/6 EMD Millipore Pathways for HLA-DRB1 (see all 6)
        Immune response Antigen presentation by MHC class II
    G-protein signaling N-RAS regulation pathway
    Immune response IL-22 signaling pathway
    Immune response NFAT in immune response
    Immune response ICOS pathway in T-helper cell

    5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HLA-DRB1 (see all 12)
        THC Differentiation Pathway
    Calcium Mediated T-Cell Apoptosis
    IL-4 Pathway
    ICos-ICosL Pathway in T-Helper Cell
    CDC42 Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for HLA-DRB1 (see all 6)
        Immune response Antigen presentation by MHC class II
    Immune response ICOS pathway in T-helper cell
    Immune response T cell receptor signaling pathway
    Immune response IL-22 signaling pathway
    G-protein signaling N-RAS regulation pathway

    5 BioSystems Pathways for HLA-DRB1 
        Cytokines and Inflammatory Response
    IL12 signaling mediated by STAT4
    IL12-mediated signaling events
    CXCR4-mediated signaling events
    TCR signaling in naive CD4+ T cells

    5/20        Reactome Pathways for HLA-DRB1 (see all 20)
        Internalization of MHC II:Ii clathrin coated vesicle
    Costimulation by the CD28 family
    Transport of MHC II:Ii complex along Golgi to TGN
    Transport of MHC II:Ii complex to plasma membrane
    Transport of antigen loaded MHC II molecules to surface


    18         Kegg Pathways  (Kegg details for HLA-DRB1) (see first 5):
        Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Hematopoietic cell lineage
    Intestinal immune network for IgA production
    Type I diabetes mellitus
    Leishmaniasis
    Toxoplasmosis
    Staphylococcus aureus infection
    Tuberculosis
    Influenza A
    Asthma
    Autoimmune thyroid disease
    Systemic lupus erythematosus
    Rheumatoid arthritis
    Allograft rejection
    Graft-versus-host disease
    Viral myocarditis


    HLA-DRB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLA-DRB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/198 Interacting proteins for HLA-DRB1 (P019122 P042292 ENSP000003530994 Q299742, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 198)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235657P018922, ENSP000003885264MINT-8407259 MINT-8407185 STRING: ENSP00000388526
    HLA-DRAP019032, ENSP000003787864MINT-24881 STRING: ENSP00000378786
    ANXA6P081332MINT-8407259 MINT-8407185
    CD81P600332MINT-8407259 MINT-8407185
    CD9P219262MINT-8407259 MINT-8407185
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002381immunoglobulin production involved in immunoglobulin mediated immune response ISS--
    GO:0002437inflammatory response to antigenic stimulus ISS--
    GO:0002455humoral immune response mediated by circulating immunoglobulin ISS--
    GO:0002504antigen processing and presentation of peptide or polysaccharide antigen via MHC class II ----
    GO:0006955immune response NAS--


    HLA-DRB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HLA-DRB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HLA-DRB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HLA-DRB1

    1 DrugBank Compound for HLA-DRB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glatiramer AcetateCOP-1 (see all 3)147245-92-9targetbinder15371592 11752352

    10/17 Novoseek chemical compound relationships for HLA-DRB1 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dr-10 77.3 6 7780115 (1), 9550403 (1), 8754259 (1), 10626740 (1)
    dr-16 73.6 1 9243764 (1)
    dpa 1 73.1 5 8782076 (1), 8863870 (1), 17060025 (1), 10616003 (1) (see all 5)
    oligonucleotide 53.4 22 8117375 (1), 12823773 (1), 15865503 (1), 18718089 (1) (see all 20)
    gold sodium thiomalate 36 2 11093435 (1)
    valine 30.5 4 9098452 (1), 8500529 (1), 10439317 (1), 2369430 (1)
    amino acid 19.7 1 1533151 (1)
    c-peptide 4.17 1 15388265 (1)
    atp 3.36 2 12658812 (2)
    lysine 0 2 7738179 (1), 7612412 (1)

    Search CenterWatch for drugs/clinical trials and news about HLA-DRB1 / 2B1G 

    Transcripts
    for HLA-DRB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HLA-DRB1 gene (2 alternative transcripts): 
    NM_001243965.1  NM_002124.3  

    Unigene Clusters for HLA-DRB1:

    Major histocompatibility complex, class II, DR beta 1
    Hs.534322  [show with all ESTs], Hs.696211  [show with all ESTs], Hs.736560  [show with all ESTs]
    Unigene Representative Sequences: AK290388, AK225690, BG484513
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000360004(uc021yvx.1 uc003obp.4 uc011dqb.1 uc011dqc.1)


    miRNA
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    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-DRB1
    Clone
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    GenScript: all cDNA clones in your preferred vector: HLA-DRB1 (NM_002124)
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    Primer
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    Additional cDNA sequence: 

    AF004817.1 AJ580838.1 D86415.1 M15070.1 M17386.1 M25266.1 M27014.1 M59798.1 

    24/70 DOTS entries (see all 70):

    DT.92410344  DT.92028787  DT.91706875  DT.95164729  DT.92047682  DT.100776434  DT.95164752  DT.92382901 
    DT.95164731  DT.121314547  DT.87079048  DT.40115364  DT.100781798  DT.100778733  DT.100650571  DT.100766538 
    DT.121314746  DT.92380890  DT.121314807  DT.95230813  DT.97857272  DT.95164743  DT.91802323  DT.92467723 

    24/89 AceView cDNA sequences (see all 89):

    M16731 X02902 BV207240 M17381 BV183568 BV201637 L42143 AH002891 
    AJ245881 AF291675 AJ297586 BV207185 M15073 AJ536121 BC024269 BV207249 
    BV207188 U84892 BV207191 X12544 BV200472 BV207037 BV200469 BV207182 

    GeneLoc Exon Structure


    Expression
    for HLA-DRB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HLA-DRB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAGCGCTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HLA-DRB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HLA-DRB1

    SOURCE GeneReport for Unigene clusters: Hs.534322 Hs.696211 Hs.736560
        SABiosciences Expression via Pathway-Focused PCR Arrays including HLA-DRB1: 
              Multiple Sclerosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    In Situ
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    Orthologs
    for HLA-DRB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-DRB1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    E2JF30_CHICK6
    (see all 3)    		 MHC class II beta chain
    (see all 3)    		 54(a)
    52(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 16(375632-376577)
    16(69833-71353)
    lizard
    (Anolis carolinensis)    		 Reptilia HLA-DPB16
    		 --
    		 45(a)
    		 1 → many
    		 GL343520.1(320149-320904)
    African clawed frog
    (Xenopus laevis)    		 Amphibia D13688.12   -- 78.3(n)    D13688.1 


    ENSEMBL Gene Tree for HLA-DRB1 (if available)
    TreeFam Gene Tree for HLA-DRB1 (if available) 

    Paralogs
    for HLA-DRB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HLA-DRB1 gene
    HLA-DRB52  HLA-DQA12  HLA-DPA12  HLA-DQB12  HLA-DRA2  HLA-DOB2  HLA-DMA2  HLA-DQB22  
    ENSG000002489932  HLA-DOA2  HLA-DMB2  HLA-DQA22  HLA-DPB12  
    18/233 SIMAP similar genes for HLA-DRB1 using alignment to 1823 protein entries:     2B11_HUMAN (see all proteins) (see all similar genes):
    HLA DRB4    HLA-DRB1*0402    HLA-DRB1*0407    HLA-DRB1*1301    HLA-DRB1*1302    HLA-DRB1*1402
    HLA-All    HLA-A null    HLA-A*03    HLA-DRB13    HLA-DRB1*1605    HLA-B27
    HLA-DRB1*1327    HLA-Cw3    HLA-DRB14    HLA-D8.2V    HLA DRB1    HLA-DRB4$0101

    HLA-DRB1 for paralogs           About GeneDecksing



    Genomic Variants
    for HLA-DRB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: 2B1G_HUMAN, Q29974
    Polymorphism: The following alleles of DRB1-1 are known: DRB1*01:01; DRB1*01:02; DRB1*01:03; DRB1*01:04; DRB1*01:05;
    DRB1*01:06; DRB1*01:07; DRB1*01:08; DRB1*01:09; DRB1*01:10; DRB1*01:11; DRB1*01:12; DRB1*01:13; DRB1*01:14;
    DRB1*01:15; DRB1*01:16; DRB1*01:17; DRB1*01:18; DRB1*01:19; DRB1*01:20 and DRB1*01:21. The sequence shown is that of
    DRB1*01:01
    Polymorphism: The following alleles of DRB1-3 are known: DRB1*03:01; DRB1*03:02; DRB1*03:03; DRB1*03:04; DRB1*03:05;
    DRB1*03:06; DRB1*03:07; DRB1*03:08; DRB1*03:09; DRB1*03:10; DRB1*03:11; DRB1*03:12; DRB1*03:13; DRB1*03:14;
    DRB1*03:15; DRB1*03:16; DRB1*03:17; DRB1*03:18; DRB1*03:19; DRB1*03:20; DRB1*03:21; DRB1*03:22; DRB1*03:23;
    DRB1*03:24; DRB1*03:25; DRB1*03:26; DRB1*03:27; DRB1*03:28; DRB1*03:29; DRB1*03:30; DRB1*03:31; DRB1*03:32;
    DRB1*03:33; DRB1*03:34; DRB1*03:35; DRB1*03:36; DRB1*03:37; DRB1*03:38; DRB1*03:39; DRB1*03:40 and DRB1*03:41. The
    sequence shown is that of DRB1*03:01
    Polymorphism: The following alleles of DRB1-4 are known: DRB1*04:01, DRB1*04:02, DRB1*04:03, DRB1*04:04, DRB1*04:05,
    DRB1*04:06, DRB1*04:07, DRB1*04:08, DRB1*04:09, DRB1*04:10, DRB1*04:11, DRB1*04:12, DRB1*04:13, DRB1*04:14,
    DRB1*04:15, DRB1*04:16, DRB1*04:17, DRB1*04:18, DRB1*04:19, DRB1*04:20, DRB1*04:21, DRB1*04:22, DRB1*04:23,
    DRB1*04:24, DRB1*04:25, DRB1*04:26, DRB1*04:27, DRB1*04:28, DRB1*04:29, DRB1*04:30, DRB1*04:31, DRB1*04:32,
    DRB1*04:33, DRB1*04:34, DRB1*04:35, DRB1*04:36, DRB1*04:37, DRB1*04:38, DRB1*04:39, DRB1*04:40, DRB1*04:41,
    DRB1*04:42, DRB1*04:43, DRB1*04:44, DRB1*04:45, DRB1*04:46, DRB1*04:47, DRB1*04:48, DRB1*04:49, DRB1*04:50,
    DRB1*04:51, DRB1*04:52, DRB1*04:53, DRB1*04:54, DRB1*04:55, DRB1*04:56, DRB1*04:57, DRB1*04:58, DRB1*04:59,
    DRB1*04:60, DRB1*04:61, DRB1*04:62, DRB1*04:63, DRB1*04:64, DRB1*04:65, DRB1*04:66, DRB1*04:67, DRB1*04:68,
    DRB1*04:69, DRB1*04:70, DRB1*04:71, DRB1*04:72, DRB1*04:73, DRB1*04:74, DRB1*04:75, DRB1*04:76, DRB1*04:77 and
    DRB1*04:78. The sequence shown is that of DRB1*04:01
    Polymorphism: The following alleles of DRB1-7 are known: DRB1*07:01, DRB1*07:03, DRB1*07:04, DRB1*07:05, DRB1*07:06,
    DRB1*07:07, DRB1*07:08, DRB1*07:09, DRB1*07:11, DRB1*07:12, DRB1*07:13, DRB1*07:14, DRB1*07:15, DRB1*07:16 and
    DRB1*07:17. The sequence shown is that of DRB1*07:01
    Polymorphism: Allele DRB1*07:01 is associated with persistent hepatitis C virus (HCV) infections [MIM:609532]
    Polymorphism: The following alleles of DRB1-8 are known: DRB1*08:01 (Dw8.1), DRB1*08:02 (Dw8.2; DRB1L), DRB1*08:03
    (Dw8.3); DRB1*08:04; DRB1*08:05, DRB1*08:06, DRB1*08:07, DRB1*08:08, DRB1*08:09, DRB1*08:10, DRB1*08:11, DRB1*08:12,
    DRB1*08:13, DRB1*08:14, DRB1*08:15, DRB1*08:16, DRB1*08:17, DRB1*08:18, DRB1*08:19, DRB1*08:20, DRB1*08:21,
    DRB1*08:22, DRB1*08:23, DRB1*08:24, DRB1*08:25, DRB1*08:26, DRB1*08:27, DRB1*08:28, DRB1*08:29, DRB1*08:30,
    DRB1*08:31, DRB1*08:32, DRB1*08:33, DRB1*08:34, DRB1*08:35 and DRB1*08:36. The sequence shown is that of DRB1*08:01
    Polymorphism: The following alleles of DRB1-9 are known: DRB1*09:01, DRB1*09:02, DRB1*09:03, DRB1*09:04, DRB1*09:05,
    DRB1*09:06, DRB1*09:07 and DRB1*09:08. The sequence shown is that of DRB1*09:01
    Polymorphism: The following alleles of DRB1-10 are known: DRB1*10:01; DRB1*10:02 and DRB1*10:03. The sequence shown is
    that of DRB1*10:01
    Polymorphism: The following alleles of DRB1-11 are known: DRB1*11:01, DRB1*11:03, DRB1*11:04, DRB1*11:05, DRB1*11:06,
    DRB1*11:07, DRB1*11:08, DRB1*11:09, DRB1*11:10, DRB1*11:11, DRB1*11:12, DRB1*11:13, DRB1*11:14, DRB1*11:15,
    DRB1*11:16, DRB1*11:17, DRB1*11:18, DRB1*11:19, DRB1*11:20, DRB1*11:21, DRB1*11:22, DRB1*11:23, DRB1*11:24,
    DRB1*11:25, DRB1*11:26, DRB1*11:27, DRB1*11:28, DRB1*11:29, DRB1*11:30, DRB1*11:31, DRB1*11:32, DRB1*11:33,
    DRB1*11:34, DRB1*11:35, DRB1*11:36, DRB1*11:37, DRB1*11:38, DRB1*11:39, DRB1*11:40, DRB1*11:41, DRB1*11:42,
    DRB1*11:43, DRB1*11:44, DRB1*11:45, DRB1*11:46, DRB1*11:47, DRB1*11:48, DRB1*11:49, DRB1*11:50, DRB1*11:51,
    DRB1*11:52, DRB1*11:53, DRB1*11:54, DRB1*11:55, DRB1*11:56, DRB1*11:57, DRB1*11:58, DRB1*11:59, DRB1*11:60,
    DRB1*11:61, DRB1*11:62, DRB1*11:63, DRB1*11:64, DRB1*11:65, DRB1*11:66, DRB1*11:67, DRB1*11:68, DRB1*11:69, DRB1*11:70
    and DRB1*11:72. The sequence shown is that of DRB1*11:01
    Polymorphism: Allele DRB1*11:01 is associated with self-limiting hepatitis C virus (HCV) infections [MIM:609532]
    Polymorphism: The following alleles of DRB1-12 are known: DRB1*12:01, DRB1*12:02, DRB1*12:03, DRB1*12:04, DRB1*12:05,
    DRB1*12:06, DRB1*12:07, DRB1*12:08, DRB1*12:09, DRB1*12:10, DRB1*12:11, DRB1*12:12, DRB1*12:13, DRB1*12:14,
    DRB1*12:15, DRB1*12:16, DRB1*12:17, DRB1*12:18 and DRB1*12:19. The sequence shown is that of DRB1*12:01
    Polymorphism: The following alleles of DRB1-13 are known: DRB1*13:01, DRB1*13:02, DRB1*13:03, DRB1*13:04, DRB1*13:05,
    DRB1*13:06, DRB1*13:07, DRB1*13:08, DRB1*13:09, DRB1*13:10, DRB1*13:11, DRB1*13:12, DRB1*13:13, DRB1*13:14,
    DRB1*13:15, DRB1*13:16, DRB1*13:17, DRB1*13:18, DRB1*13:19, DRB1*13:20, DRB1*13:21, DRB1*13:22, DRB1*13:23,
    DRB1*13:24, DRB1*13:25, DRB1*13:26, DRB1*13:27, DRB1*13:28, DRB1*13:29, DRB1*13:30, DRB1*13:31, DRB1*13:32,
    DRB1*13:33, DRB1*13:34, DRB1*13:35, DRB1*13:36, DRB1*13:37, DRB1*13:38, DRB1*13:39, DRB1*13:40, DRB1*13:41,
    DRB1*13:42, DRB1*13:43, DRB1*13:44, DRB1*13:45, DRB1*13:46, DRB1*13:47, DRB1*13:48, DRB1*13:49, DRB1*13:50,
    DRB1*13:51, DRB1*13:52, DRB1*13:53, DRB1*13:54, DRB1*13:55, DRB1*13:56, DRB1*13:57, DRB1*13:58, DRB1*13:59,
    DRB1*13:60, DRB1*13:61, DRB1*13:62, DRB1*13:63, DRB1*13:64, DRB1*13:65, DRB1*13:66, DRB1*13:67, DRB1*13:68,
    DRB1*13:69, DRB1*13:70, DRB1*13:71, DRB1*13:72, DRB1*13:73, DRB1*13:74, DRB1*13:75, DRB1*13:76, DRB1*13:77,
    DRB1*13:78, DRB1*13:79, DRB1*13:80, DRB1*13:81, DRB1*13:82, DRB1*13:83, DRB1*13:84, DRB1*13:85, DRB1*13:86, DRB1*13:87
    and DRB1*13:88. The sequence shown is that of DRB1*13:01
    Polymorphism: The following alleles of DRB1-14 are known: DRB1*14:01, DRB1*14:02, DRB1*14:03, DRB1*14:04, DRB1*14:05,
    DRB1*14:06, DRB1*14:07, DRB1*14:08, DRB1*14:09, DRB1*14:10, DRB1*14:11, DRB1*14:12, DRB1*14:13, DRB1*14:14,
    DRB1*14:15, DRB1*14:16, DRB1*14:17, DRB1*14:18, DRB1*14:19, DRB1*14:20, DRB1*14:21, DRB1*14:22, DRB1*14:23,
    DRB1*14:24, DRB1*14:25, DRB1*14:26, DRB1*14:27, DRB1*14:28, DRB1*14:29, DRB1*14:30, DRB1*14:31, DRB1*14:32,
    DRB1*14:33, DRB1*14:34, DRB1*14:35, DRB1*14:36, DRB1*14:37, DRB1*14:38, DRB1*14:39, DRB1*14:40, DRB1*14:41,
    DRB1*14:42, DRB1*14:43, DRB1*14:44, DRB1*14:45, DRB1*14:46, DRB1*14:47, DRB1*14:48, DRB1*14:49, DRB1*14:50,
    DRB1*14:51, DRB1*14:52, DRB1*14:53, DRB1*14:54, DRB1*14:55, DRB1*14:56, DRB1*14:57, DRB1*14:58, DRB1*14:59,
    DRB1*14:60, DRB1*14:61, DRB1*14:62, DRB1*14:63, DRB1*14:64, DRB1*14:65, DRB1*14:67, DRB1*14:68, DRB1*14:69,
    DRB1*14:70, DRB1*14:71, DRB1*14:72, DRB1*14:73, DRB1*14:74, DRB1*14:75, DRB1*14:76, DRB1*14:77, DRB1*14:78,
    DRB1*14:79, DRB1*14:80, DRB1*14:81, DRB1*14:82, DRB1*14:83, DRB1*14:84 and DRB1*14:85. The sequence shown is that of
    DRB1*14:01
    Polymorphism: The following alleles of DRB1-15 are known: DRB1*15:01, DRB1*15:02, DRB1*15:03, DRB1*15:04, DRB1*15:05,
    DRB1*15:06, DRB1*15:07, DRB1*15:08, DRB1*15:09, DRB1*15:10, DRB1*15:11, DRB1*15:12, DRB1*15:13, DRB1*15:14,
    DRB1*15:15, DRB1*15:16, DRB1*15:18, DRB1*15:19, DRB1*15:20, DRB1*15:21, DRB1*15:22, DRB1*15:23, DRB1*15:24,
    DRB1*15:25, DRB1*15:26, DRB1*15:27, DRB1*15:28, DRB1*15:29, DRB1*15:30, DRB1*15:31 and DRB1*15:32. The sequence shown
    is that of DRB1*15:01
    Polymorphism: The following alleles of DRB1-16 are known: DRB1*16:01; DRB1*16:02; DRB1*16:03; DRB1*16:04; DRB1*16:05;
    DRB1*16:07; DRB1*16:08; DRB1*16:09; DRB1*16:10; DRB1*16:11 and DRB1*16:12. The sequence shown is that of DRB1*16:02


    10/2620 NCBI SNPs in HLA-DRB1 are shown (see all 2620)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs10598081,2
    		C--32291334(-) GGGCTG/ATTCAT 2 /L syn11Minor allele frequency- A:0.00NA 2
    rs38301261,2
    		C--32291340(-) GGGGCA/CGGGCT 2 A syn10--------
    rs178796201,2
    		C--32294676(-) CACCTA/TCTGCA 2 Y F mis10--------
    rs178840431,2
    		C--32294677(-) ACACCC/G/TACTGC 3 H D Y mis10--------
    rs168228531,2
    		C,F--32294697(-) GCAGGA/C/GGCGGG 3 K T R mis12MN 368
    rs178786221,2
    		C--32294750(-) GAGCTA/GGGGCG 2 L syn10--------
    rs10595821,2
    		C,F,--32294757(-) GGTGAC/G/TGGAGC 3 T R M mis11EU 401
    rs178820141,2
    		C--32294869(-) AGAGGA/GAGTGT 2 K E mis10--------
    rs719457571,2
    		C,--32546054(+) CTCTC-/AGAT  
                AGAAC     		3 -- ds50010--------
    rs412871501,2
    		C,--32546056(+) CTCAGA/GTAGAA 3 -- ds50014Minor allele frequency- G:0.30WA NA EA 360

    HapMap Linkage Disequilibrium report for HLA-DRB1 (32546546 - 32557625 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 22 variations for HLA-DRB1
         15/20 CNVs (see all 20): 7567 69436 37840 69447 69420 4767 4493 64476 3603 69431 69407 69452 81340 69421 93647
         2 Indels: 33807 12831
    Human Gene Mutation Database (HGMD): HLA-DRB1

    Locus Specific Mutation Databases (LSDB): HLA-DRB1

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-DRB1
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-DRB1

    Disorders / Diseases
    for HLA-DRB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HLA-DRB1 for disorders           About GeneDecksing

    OMIM gene information: 142857   
    OMIM disorders: 181000  126200  180300  
    UniProtKB/Swiss-Prot: 2B1G_HUMAN, Q29974
  • Genetic variation in HLA-DRB1 is a cause of susceptibility to sarcoidosis type 1 (SS1) [MIM:181000].
    • Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in
    involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen,
    eyes and other organs may be involved

    20/358 diseases for HLA-DRB1 (see all 358):    About MalaCards
    vogt-koyanagi-harada disease    pure red-cell aplasia    sarcoidosis, susceptibility l, 1    kleine-levin syndrome
    alpha 1-antitrypsin deficiency    21-hydroxylase deficiency    graft versus host disease    pars planitis
    adult-onset still's disease    porphyria cutanea tarda    polymyalgia rheumatica    epidermolysis bullosa acquisita
    relapsing-remitting multiple sclerosis    churg-strauss syndrome    rhizomelic pseudopolyarthritis    avascular necrosis of femoral head
    paroxysmal nocturnal hemoglobinuria    toxic epidermal necrolysis    chronic inflammatory demyelinating polyradiculoneuropathy    stevens-johnson syndrome

    9 diseases from the University of Copenhagen DISEASES database for HLA-DRB1:
    Hypersensitivity reaction type II disease     Rheumatoid arthritis     Diabetes mellitus     Hyperthyroidism
    Connective tissue disease     Thyroiditis     Skin disease     Leprosy
    Multiple sclerosis

    10/53 Novoseek disease relationships for HLA-DRB1 gene (see all 53)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 66.3 64 1416553 (3), 16277691 (2), 16385499 (2), 10765919 (2) (see all 44)
    genetic susceptibility 65.2 8 17055211 (1), 17047287 (1), 17309132 (1), 18004301 (1) (see all 8)
    polymyalgia rheumatica 58.1 10 10225816 (2), 8147928 (2), 9458210 (2), 15305244 (2) (see all 5)
    diabetes mellitus insulin-dependent 50.2 2 10680451 (1), 7817375 (1)
    autoimmune diseases 49.3 5 16362107 (1), 19117368 (1), 16198136 (1), 1617108 (1) (see all 5)
    vogt-koyanagi-harada disease 46.6 2 7906684 (1), 15603876 (1)
    autoimmunity 44.1 4 16385499 (1), 17987563 (1), 15120192 (1), 8675578 (1)
    hepatitis autoimmune 44 3 1350267 (2), 9672174 (1)
    pemphigus foliaceus 36.9 1 9027963 (1)
    diabetes autoimmune 35.6 2 10333055 (1), 18279373 (1)

    Genetic Association Database (GAD): HLA-DRB1
    Human Genome Epidemiology (HuGE) Navigator: HLA-DRB1 (1845 documents)

    Export disorders for HLA-DRB1 gene to outside databases

    Publications
    for HLA-DRB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HLA-DRB1 gene, integrated from 9 sources (see all 2487):
    (articles sorted by number of sources associating them with HLA-DRB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. [Determination of HLA-DRB1 gene polymorphism in Luoba ethnic group of Tibet] (PubMed id 15898419)1, 4, 9 Kang L.L....Li S.B. (2005)
    2. Influence of HLA-DRB1 and TNF microsatellite polymorphisms on the expression of extraarticular manifestations in rheumatoid arthritis patients from northwest Spain. (PubMed id 11791643)1, 4, 9 Mattey D.L....Ollier W.E. (2001)
    3. [Possible association between HLA-HRB1 and DQB1 genes frequency and susceptibility or resistance to Helicobacter pylori infection in Kunming Yi ethnic group children] (PubMed id 15833172)1, 4, 9 Huang Y.K....Zhou L.F. (2005)
    4. [Association of HLA-A, B, and DR haplotypes with genotype in Chinese children with systemic lupus erythematosus] (PubMed id 14748996)1, 4, 9 Li C.F....Jiang Z.F. (2003)
    5. [Polymorphism of length of tetranucleotide repeat from the 5'-side from the myelin basic protein gene in multiple sclerosis in Russians] (PubMed id 14714495)1, 4, 9 Andreevskii T.V....Favorova O.O. (2003)
    6. HLA-DRB1 and HLA-DQB1 polymorphisms in Pacific Islands populations. (PubMed id 12144623)1, 4, 9 Velickovic Z.M....Carter J.M. (2002)
    7. Collagenase-1 (MMP-1) and HLA-DRB1 gene polymorphisms in rheumatoid arthritis: a prospective longitudinal study. (PubMed id 11824952)1, 4, 9 Constantin A....Cantagrel A. (2002)
    8. Association between protein tyrosine phosphatase 22 variant R620W in conjunction with the HLA-DRB1 shared epitope and humoral autoimmunity to an immunodominant epitope of cartilage-specific type II collagen in early rheumatoid arthritis. (PubMed id 16385499)1, 4, 9 Burkhardt H....Reis A. (2006)
    9. [Polymorphism of HLA-A,-B and DRB1 in Han population of Shanxi province] (PubMed id 16215957)1, 4, 9 Lan T....Wang G.Q. (2005)
    10. The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis. (PubMed id 16277691)1, 4, 9 Turesson C....Matteson E.L. (2005)

    External Searches for HLA-DRB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing HLA-DRB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3123 HGNC: 4948 AceView: HLA-DRB1.1 Ensembl:ENSG00000196126 euGenes: HUgn3123
    ECgene: HLA-DRB1 Kegg: 3123 H-InvDB: HLA-DRB1

    Other Databases showing HLA-DRB1 gene

    (According to HUGE)
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    Specialized Databases showing HLA-DRB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HLA-DRB1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HLA-DRB1 gene:
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