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HLA-DRB1 Gene

protein-coding   GIFtS: 65
GCID: GC06M032546

Major Histocompatibility Complex, Class II, DR Beta 1


(Previous symbol: HLA-DR1B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Major Histocompatibility Complex, Class II, DR Beta 11 2     DR133
HLA-DR1B1 2     DR143
DRw102 3     DR163
DW2.2/DR2.22 3     DR43
SS12 5     DR53
DRB12     DR73
HLA-DRB2     DR83
HLA Class II Histocompatibility Antigen, DR-1 Beta Chain2     DR93
Human Leucocyte Antigen DRB12     DRw113
Lymphocyte Antigen DRB12     DRw83
MHC Class II Antigen2     HLA-DRB23
MHC Class II HLA-DR Beta 1 Chain2     Clone P2-Beta-33
MHC Class II HLA-DR-Beta Cell Surface Glycoprotein2     MHC Class II Antigen DRB1*13
MHC Class II HLA-DRw10-Beta2     MHC Class II Antigen DRB1*103
DR-13     MHC Class II Antigen DRB1*113
DR-123     MHC Class II Antigen DRB1*123
DR-133     MHC Class II Antigen DRB1*133
DR-143     MHC Class II Antigen DRB1*143
DR-163     MHC Class II Antigen DRB1*153
DR-43     MHC Class II Antigen DRB1*163
DR-53     MHC Class II Antigen DRB1*33
DR-73     MHC Class II Antigen DRB1*43
DR-83     MHC Class II Antigen DRB1*73
DR-93     MHC Class II Antigen DRB1*83
DR13     MHC Class II Antigen DRB1*93
DR123     

External Ids:    HGNC: 49481   Entrez Gene: 31232   Ensembl: ENSG000001961267   OMIM: 1428575   UniProtKB: P042293   
UniProtKB: P019123   UniProtKB: P137603   UniProtKB: P137613   UniProtKB: Q301343   UniProtKB: Q9TQE03   
UniProtKB: Q301673   UniProtKB: P200393   UniProtKB: Q95IE33   UniProtKB: Q5Y7A73   UniProtKB: Q9GIY33   
UniProtKB: P019113   UniProtKB: Q299743   

Export aliases for HLA-DRB1 gene to outside databases

Previous GC identifers: GC06U990049 GC06Md32547 GC06M032317 GC06Md32654 GC06M032656


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HLA-DRB1 Gene:
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an
alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system
by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen
presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa.
It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular
domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule
the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1
alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney
transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is
present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4
and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. (provided by RefSeq, Jul 2008)

GeneCards Summary for HLA-DRB1 Gene:
HLA-DRB1 (major histocompatibility complex, class II, DR beta 1) is a protein-coding gene. Diseases associated with HLA-DRB1 include bullous pemphigoid, and rhizomelic pseudopolyarthritis. GO annotations related to this gene include MHC class II receptor activity and peptide antigen binding. An important paralog of this gene is HLA-DRB5.

UniProtKB/Swiss-Prot: 2B11_HUMAN, P04229 (see all)
Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
(class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the
regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
efficient peptide loading

Gene Wiki entry for HLA-DRB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NT_167245.2  NT_167246.2  NT_113891.3  NT_167248.2  NC_000006.12  NC_018917.2  NT_007592.16  NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HLA-DRB1 gene promoter:
         HOXA3   AML1a   p53   CUTL1   CBF-C   YY1   CBF-B   CBF-A   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLA-DRB1 promoter sequence
   Search Chromatin IP Primers for HLA-DRB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-DRB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

HLA-DRB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-DRB1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032546:  view genomic region     (about GC identifiers)

Start:
32,546,546 bp from pter      End:
32,557,625 bp from pter
Size:
11,080 bases      Orientation:
minus strand

4 alternative locations:
Chr6-,NT_167248 3,784,600-3,797,961      Chr6-,NT_167244 3,774,424-3,787,494      Chr6-,NT_113891.2 3,998,151-4,011,502     
Chr6-,NT_167249 3,978,426-3,993,112     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 2B11_HUMAN, P04229 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen, DRB1-1 beta chain precursor  
Size: 266 amino acids; 29914 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Selected PDB 3D structures from and Proteopedia for HLA-DRB1 (see all 40):
1AQD (3D)        1DLH (3D)        1FYT (3D)        1HXY (3D)        1JWM (3D)        1JWS (3D)    
Secondary accessions: A4F5N0 A8K098 O62869 P13758 Q06662 Q30116 Q30117 Q5Y7E9 Q7M2H4 Q95461
Q9BCL7 Q9GIK5 Q9MXZ0 Q9MXZ5 Q9TQ91

UniProtKB/Swiss-Prot: 2B13_HUMAN, P01912 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-3 chain precursor  
Size: 266 amino acids; 30120 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
1 PDB 3D structure from and Proteopedia for HLA-DRB1:
1A6A (3D)    

UniProtKB/Swiss-Prot: 2B14_HUMAN, P13760 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-4 beta chain precursor  
Size: 266 amino acids; 30112 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Selected PDB 3D structures from and Proteopedia for HLA-DRB1 (see all 16):
1D5M (3D)        1D5X (3D)        1D5Z (3D)        1D6E (3D)        1J8H (3D)        2SEB (3D)    
Secondary accessions: O19717 O19739 P13759 Q29875 Q30145 Q9GIX9 Q9GIY4 Q9MY13 Q9XRY5

UniProtKB/Swiss-Prot: 2B17_HUMAN, P13761 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-7 beta chain precursor  
Size: 266 amino acids; 29822 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Secondary accessions: B0UYW1 O46699 O46872

UniProtKB/Swiss-Prot: 2B18_HUMAN, Q30134 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-8 beta chain precursor  
Size: 266 amino acids; 30004 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Secondary accessions: O19718 O19788 Q29968 Q30108 Q30115 Q9BCP0 Q9BCP1 Q9BCP2 Q9BD33 Q9TQ37
Q9UIM9

UniProtKB/Swiss-Prot: 2B19_HUMAN, Q9TQE0 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-9 beta chain precursor  
Size: 266 amino acids; 29826 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Secondary accessions: Q30149

UniProtKB/Swiss-Prot: 2B1A_HUMAN, Q30167 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-10 beta chain precursor  
Size: 266 amino acids; 30002 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Secondary accessions: P01914 Q9MYF5

UniProtKB/Swiss-Prot: 2B1B_HUMAN, P20039 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-11 beta chain precursor  
Size: 266 amino acids; 30160 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Secondary accessions: Q30006 Q9GIX8

UniProtKB/Swiss-Prot: 2B1C_HUMAN, Q95IE3 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-12 beta chain precursor  
Size: 266 amino acids; 29878 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Secondary accessions: A7LA26 B0LUZ6 B6VCX2 B7UDB2 O19585 Q19AF2 Q29771 Q2L9H4 Q2MZ92 Q5EER6
Q5NDB9 Q5UT58 Q5Y7G0 Q768U4 Q7YP04 Q861H8 Q95IT6 Q9BD40

UniProtKB/Swiss-Prot: 2B1D_HUMAN, Q5Y7A7 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-13 beta chain precursor  
Size: 266 amino acids; 30008 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Sequence caution: Sequence=CAB40418.1; Type=Erroneous gene model prediction;
Secondary accessions: A0MWF2 A2ICT1 A4ZXA5 A4ZXA6 A7UHG2 A7X5K7 A8YQE9 B0BK85 B3VTQ3 B5A8Y2
B5A8Y3 B5B9V6 B5QSK8 C0LAB5 O02930 O62889 O78047 P79545 Q14280 Q14QT2 Q19K86 Q1G0Z9 Q1KLJ6
Q29673 Q29720 Q29722 Q29806 Q29833 Q29874 Q29886 Q2MF40 Q2YHQ2 Q30112 Q3LA93 Q3LA94 Q3LA95
Q3LA96 Q3LA97 Q3LA98 Q3LA99 Q3LAA0 Q3LAA1 Q3LAA2 Q3MQ60 Q53IG1 Q56FP2 Q56FP3 Q58F52 Q5K3W2
Q5UBA2 Q5W3L4 Q6REE2 Q6U387 Q701T1 Q70Q85 Q768U2 Q7YP03 Q7YQ26 Q7YQA3 Q860E5 Q860H8 Q860Z3
Q861G6 Q861H0 Q861H4 Q8HWQ6 Q8WMA0 Q95389 Q95HL1 Q96HZ9 Q9BCP5 Q9BD21 Q9GIP3 Q9GJ25 Q9GJ60
Q9GJF8 Q9GJF9 Q9GJG0 Q9MY45 Q9MY56 Q9TPW3 Q9TPW9 Q9TPX4 Q9UBY1 Q9UIN0 Q9XRX1 Q9Y453

UniProtKB/Swiss-Prot: 2B1E_HUMAN, Q9GIY3 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-14 beta chain precursor  
Size: 266 amino acids; 30139 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Sequence caution: Sequence=CAB45249.1; Type=Erroneous gene model prediction;
Secondary accessions: A0N0W1 A2TGX3 A4ZY86 A5H000 A5HKN8 A7DZP9 A7X5B1 A7X5B7 A7X5E0 A7X5E6
A7X5H8 A9JPG0 B1GWE7 B2CR03 B2LVF9 B2NJ29 B2ZCY1 B3VTP8 B5B8U0 B5B9V5 B5LZ25 B6VEL9 B9VRA4
B9X248 O02876 O46793 O77969 O78210 Q0PQ39 Q155F7 Q1AP33 Q1JRP3 Q27PR6 Q27PR7 Q29734 Q29770
Q29772 Q29800 Q2A120 Q2HZE5 Q2LE76 Q2MJA6 Q2VQU1 Q307W5 Q31636 Q3LA87 Q3LA88 Q3LA89 Q3LA90
Q3LA91 Q3LA92 Q3T919 Q4PRC3 Q4PRC5 Q4VZY7 Q56FP1 Q5BM92 Q5U9W6 Q683P7 Q70GL2 Q7YNY9 Q7YQA5
Q860D8 Q860D9 Q860S0 Q861H5 Q861H7 Q8MH59 Q8MH60 Q8WLU3 Q95348 Q95HK1 Q95HL0 Q95IG2 Q9GIL5
Q9GIL6 Q9GIY0 Q9GIY1 Q9GIY2 Q9GJ56 Q9GJ57 Q9GJ58 Q9TPB6 Q9TPW1 Q9XRY4 Q9Y4H7

UniProtKB/Swiss-Prot: 2B1F_HUMAN, P01911 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-15 beta chain precursor  
Size: 266 amino acids; 29966 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Miscellaneous: The chain shown constituted about 70% of a pool of at least seven similar beta chains
3 PDB 3D structures from and Proteopedia for HLA-DRB1:
1BX2 (3D)        1YMM (3D)        2WBJ (3D)    
Secondary accessions: Q29790 Q29975 Q30142 Q30166 Q32MY7 Q56FN9 Q5Y7B0 Q5Y7B9

UniProtKB/Swiss-Prot: 2B1G_HUMAN, Q29974 (See protein sequence)

Recommended Name: HLA class II histocompatibility antigen, DRB1-16 beta chain precursor  
Size: 266 amino acids; 30030 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Secondary accessions: A7X5J4 O98212 Q0PGR5 Q29792 Q30120 Q30159 Q30200 Q3HUP9 Q3KTM1 Q3LA84
Q6T865 Q95383

Explore the universe of human proteins at neXtProt for HLA-DRB1: NX_Q29974

Explore proteomics data for HLA-DRB1 at MOPED

Post-translational modifications: 

  • Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to sorting into the endosome system and down-regulation of
    MHC class II (Probable)1
  • Ubiquitination2 at Lys254
  • Glycosylation2 at Asn48
  • Modification sites at PhosphoSitePlus (HLA-DRB4)

  • See HLA-DRB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230894.1  NP_002115.2  

    ENSEMBL proteins: 
     ENSP00000353099  
    Reactome Protein details: Q30167 Q5Y7A7 P04229 Q9TQE0 Q9GIY3 P01911 Q29974 P20039 Q95IE3 P01912 P13760 Q30134 P13761

    HLA-DRB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HLA-DRB1
    OriGene Protein Over-expression Lysate for HLA-DRB1
    OriGene MassSpec for HLA-DRB1
    OriGene Custom Protein Services for HLA-DRB1
    GenScript Custom Purified and Recombinant Proteins Services for HLA-DRB1
    Novus Biologicals HLA-DRB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    HLA-DRB1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HLA-DRB1
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HLA-DRB1
    OriGene Custom Antibody Services for HLA-DRB1
    Novus Biologicals HLA-DRB1 Antibodies
    Abcam antibodies for HLA-DRB1 (Q30120, P01911, P20039, P13761)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for HLA-DRB1
    LSBio Antibodies in human, mouse, rat for HLA-DRB1

    HLA-DRB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HLA-DRB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HLA-DRB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    HGNC Gene Families:
    HLA: Histocompatibility complex
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    Selected InterPro protein domains (see all 7):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR000353 MHC_II_b_N
     IPR013783 Ig-like_fold
     IPR014745 MHC_II_a/b_N
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry P04229
    Graphical View of Domain Structure for InterPro Entry P01912
    Graphical View of Domain Structure for InterPro Entry P13760
    Graphical View of Domain Structure for InterPro Entry P13761
    Graphical View of Domain Structure for InterPro Entry Q30134
    Graphical View of Domain Structure for InterPro Entry Q9TQE0
    Graphical View of Domain Structure for InterPro Entry Q30167
    Graphical View of Domain Structure for InterPro Entry P20039
    Graphical View of Domain Structure for InterPro Entry Q95IE3
    Graphical View of Domain Structure for InterPro Entry Q5Y7A7
    Graphical View of Domain Structure for InterPro Entry Q9GIY3
    Graphical View of Domain Structure for InterPro Entry P01911
    Graphical View of Domain Structure for InterPro Entry Q29974

    ProtoNet protein and cluster: P04229

    2 Blocks protein domains:
    IPB000353 Class II histocompatibility antigen
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: 2B11_HUMAN, P04229
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B13_HUMAN, P01912
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B14_HUMAN, P13760
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B17_HUMAN, P13761
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B18_HUMAN, Q30134
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B19_HUMAN, Q9TQE0
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1A_HUMAN, Q30167
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1B_HUMAN, P20039
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1C_HUMAN, Q95IE3
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1D_HUMAN, Q5Y7A7
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1E_HUMAN, Q9GIY3
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1F_HUMAN, P01911
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain

    UniProtKB/Swiss-Prot: 2B1G_HUMAN, Q29974
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    HLA-DRB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Molecular Function:
    UniProtKB/Swiss-Prot Summary: 2B11_HUMAN, P04229 (see all)
    Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
    and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
    peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
    of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
    hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
    via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
    As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
    contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
    endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
    MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
    epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
    tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
    an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
    of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
    degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
    (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
    the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
    affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
    membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
    Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the
    regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
    efficient peptide loading

         Genatlas biochemistry entry for HLA-DRB1:
    HLA-DR,beta 1 chain,determining DR1,3,4,5 etc

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0023026MHC class II protein complex binding IDA--
    GO:0032395MHC class II receptor activity TAS3456344
    GO:0042605peptide antigen binding ISS--
         
    HLA-DRB1 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    2B11_HUMAN, P04229: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B13_HUMAN, P01912: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B14_HUMAN, P13760: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B17_HUMAN, P13761: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B18_HUMAN, Q30134: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B19_HUMAN, Q9TQE0: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B1A_HUMAN, Q30167: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B1B_HUMAN, P20039: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B1C_HUMAN, Q95IE3: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B1D_HUMAN, Q5Y7A7: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B1E_HUMAN, Q9GIY3: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B1F_HUMAN, P01911: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    2B1G_HUMAN, Q29974: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits
    through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for
    antigen presentation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome5
    lysosome5
    plasma membrane5
    vacuole5
    golgi apparatus4
    extracellular2
    nucleus2
    cytoskeleton1
    cytosol1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005765lysosomal membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS3456344
    GO:0009897external side of plasma membrane ISS--

    HLA-DRB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

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    SuperPaths for HLA-DRB1 About   (see all 30)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Allograft rejection
    Allograft rejection0.86
    Intestinal immune network for IgA production0.41
    Allograft Rejection0.86
    Viral myocarditis0.40
    Type I diabetes mellitus0.69
    CTL Mediated Apoptosis0.38
    Graft-versus-host disease0.65
    THC Differentiation Pathway0.38
    2CD28 co-stimulation
    Costimulation by the CD28 family0.44
    CTLA4 Signaling0.30
    3Translocation of ZAP-70 to Immunological synapse
    Translocation of ZAP-70 to Immunological synapse0.83
    PD-1 signaling0.72
    Phosphorylation of CD3 and TCR zeta chains0.83
    Generation of second messenger molecules0.62
    4Immune response Antigen presentation by MHC class II
    Immune response Antigen presentation by MHC class II0.46
    Immune response IL 22 signaling pathway0.31
    G protein signaling N RAS regulation pathway0.46
    5ICos-ICosL Pathway in T-Helper Cell
    ICos-ICosL Pathway in T-Helper Cell0.66
    Calcium Mediated T-Cell Apoptosis0.31
    CD28 Signaling in T-Helper Cell0.66

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HLA-DRB1 (see all 12)
        THC Differentiation Pathway
    Calcium Mediated T-Cell Apoptosis
    IL-4 Pathway
    ICos-ICosL Pathway in T-Helper Cell
    CDC42 Pathway

    Selected GeneGo (Thomson Reuters) Pathways for HLA-DRB1 (see all 6)
        Immune response Antigen presentation by MHC class II
    Immune response ICOS pathway in T-helper cell
    Immune response T cell receptor signaling pathway
    Immune response IL-22 signaling pathway
    G-protein signaling N-RAS regulation pathway

    Selected BioSystems Pathways for HLA-DRB1 (see all 6)
        Cytokines and Inflammatory Response
    Allograft Rejection
    IL12-mediated signaling events
    TCR signaling in naive CD4+ T cells
    IL12 signaling mediated by STAT4

    Selected Reactome Pathways for HLA-DRB1 (see all 7)
        Translocation of ZAP-70 to Immunological synapse
    Interferon gamma signaling
    Downstream TCR signaling
    PD-1 signaling
    MHC class II antigen presentation


    Selected Kegg Pathways  (Kegg details for HLA-DRB1) (see all 22):
        Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Hematopoietic cell lineage
    Intestinal immune network for IgA production


    HLA-DRB1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HLA-DRB1: 
              Multiple Sclerosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HLA-DRB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HLA-DRB1 (P019122 P042292 ENSP000003530994 Q299742, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 200)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235657P018922, ENSP000003885264MINT-8407259 MINT-8407185 STRING: ENSP00000388526
    ENSG00000227993P019032, ENSP000003726084MINT-24881 STRING: ENSP00000372608
    ENSG00000228987P019032, ENSP000004104434MINT-24881 STRING: ENSP00000410443
    HLA-DRAP019032, ENSP000003787864MINT-24881 STRING: ENSP00000378786
    ENSG00000206308P019032, ENSP000003727464MINT-24881 STRING: ENSP00000372746
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002381immunoglobulin production involved in immunoglobulin mediated immune response ISS--
    GO:0002437inflammatory response to antigenic stimulus ISS--
    GO:0002455humoral immune response mediated by circulating immunoglobulin ISS--
    GO:0006955immune response NAS3129499
    GO:0016045detection of bacterium ISS--

    HLA-DRB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HLA-DRB1 (2B1G)

    1 DrugBank Compound for HLA-DRB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glatiramer AcetateCOP-1 (see all 3)147245-92-9targetbinder15371592 11752352

    Selected Novoseek inferred chemical compound relationships for HLA-DRB1 gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dr-10 77.3 6 7780115 (1), 9550403 (1), 8754259 (1), 10626740 (1)
    dr-16 73.6 1 9243764 (1)
    dpa 1 73.1 5 8782076 (1), 8863870 (1), 17060025 (1), 10616003 (1) (see all 5)
    oligonucleotide 53.4 22 8117375 (1), 12823773 (1), 15865503 (1), 18718089 (1) (see all 20)
    gold sodium thiomalate 36 2 11093435 (1)
    valine 30.5 4 9098452 (1), 8500529 (1), 10439317 (1), 2369430 (1)
    amino acid 19.7 1 1533151 (1)
    c-peptide 4.17 1 15388265 (1)
    atp 3.36 2 12658812 (2)
    lysine 0 2 7738179 (1), 7612412 (1)

    1 PharmGKB related drug/compound annotation for HLA-DRB1 gene    About this table
    Drug/compound PharmGKB Annotation
    lapatinib



    HLA-DRB1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for HLA-DRB1 gene (2 alternative transcripts): 
    NM_001243965.1  NM_002124.3  

    Unigene Cluster for HLA-DRB1:

    Major histocompatibility complex, class II, DR beta 1
    Hs.534322  [show with all ESTs]
    Unigene Representative Sequence: AK290388
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000360004(uc021yvx.1 uc003obp.4 uc011dqb.1 uc011dqc.1)

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      QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB1

    Additional mRNA sequence: 

    AB062112.2 AF017440.1 AF097680.1 AF436097.1 AF490771.1 AJ011065.1 AK290388.1 AK292140.1 
    AK314834.1 AY052550.1 AY054375.1 BC009234.2 FJ200455.1 HM627215.1 M15068.1 M15178.1 
    M15992.1 M16086.1 M16731.1 M16954.1 M16955.1 M16956.1 M17377.1 M17383.1 
    M17384.1 M17387.1 M20429.1 M20503.1 M25265.1 M27015.1 M27689.1 M30181.1 
    M30182.1 M32578.1 M35980.1 M35981.1 M57648.1 M59803.1 S79787.1 U17380.1 
    U17381.1 U31770.1 U35375.1 U35729.1 U37433.1 U37582.1 U66826.1 U70543.1 
    U95818.1 X99895.1 

    Selected DOTS entries (see all 50):

    DT.92028787  DT.100776434  DT.92410344  DT.121314547  DT.40115364  DT.91706875  DT.92047682  DT.100781798 
    DT.95164729  DT.121314807  DT.95164752  DT.95164731  DT.100778733  DT.99961180  DT.95164743  DT.91802323 
    DT.95129328  DT.97857272  DT.100766538  DT.121314566  DT.121314746  DT.100650571  DT.100776431  DT.91661820 

    Selected AceView cDNA sequences (see all 89):

    M16731 L42143 X02902 AH002891 AF291675 AJ297586 AJ536121 M15073 
    AJ245881 BV207185 BV183568 BV207240 BC024269 BV201637 M17381 BV200472 
    M15070 BV183567 BV200462 BV207191 BV207249 BV207036 M15069 BV207037 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HLA-DRB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGCGCTGA
    HLA-DRB1 Expression
    About this image


    HLA-DRB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
    HLA-DRB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HLA-DRB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534322
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HLA-DRB1: 
              Multiple Sclerosis in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HLA-DRB1
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-DRB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HLA-DRB1
    QuantiTect SYBR Green Assays in human, mouse, rat HLA-DRB1
    QuantiFast Probe-based Assays in human, mouse, rat HLA-DRB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DRB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-DRB1 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia H2-Eb15 histocompatibility 2, class II antigen E beta   --   17 (17.98 cM) 34305883 
    African clawed frog
    (Xenopus laevis)
    Amphibia D13688.12   -- 78.3(n)    D13688.1 


    ENSEMBL Gene Tree for HLA-DRB1 (if available)
    TreeFam Gene Tree for HLA-DRB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for HLA-DRB1 gene
    HLA-DRB52  HLA-DQA12  HLA-DPA12  HLA-DQB12  HLA-DRA2  HLA-DOB2  HLA-DMA2  HLA-DQB22  
    HLA-DOA2  ENSG000002489932  HLA-DMB2  HLA-DQA22  HLA-DPB12  
    Selected SIMAP similar genes for HLA-DRB1 using alignment to 2155 protein entries:     2B11_HUMAN (see all proteins) (see all similar genes):
    HLA DRB4    HLA-DRB1*1301    HLA-DRB1*1302    HLA-DRB1*1402    HLA-DRB1*0402    HLA-DRB1*0407
    HLA-All    HLA-A null    HLA-A*03    HLA-DRB13    HLA-B27    HLA-DRB1*1605
    HLA-DRB1*1327    HLA-DRB14    HLA-Cw3    HLA-D8.2V    HLA-DRB4$0101    DRB52

    HLA-DRB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Polymorphic Variants from UniProtKB/Swiss-Prot
    2B11_HUMAN, P04229: The following alleles of DRB1-1 are known: DRB1*01:01; DRB1*01:02; DRB1*01:03; DRB1*01:04;
    DRB1*01:05; DRB1*01:06; DRB1*01:07; DRB1*01:08; DRB1*01:09; DRB1*01:10; DRB1*01:11; DRB1*01:12; DRB1*01:13;
    DRB1*01:14; DRB1*01:15; DRB1*01:16; DRB1*01:17; DRB1*01:18; DRB1*01:19; DRB1*01:20 and DRB1*01:21. The sequence
    shown is that of DRB1*01:01
    2B13_HUMAN, P01912: The following alleles of DRB1-3 are known: DRB1*03:01; DRB1*03:02; DRB1*03:03; DRB1*03:04;
    DRB1*03:05; DRB1*03:06; DRB1*03:07; DRB1*03:08; DRB1*03:09; DRB1*03:10; DRB1*03:11; DRB1*03:12; DRB1*03:13;
    DRB1*03:14; DRB1*03:15; DRB1*03:16; DRB1*03:17; DRB1*03:18; DRB1*03:19; DRB1*03:20; DRB1*03:21; DRB1*03:22;
    DRB1*03:23; DRB1*03:24; DRB1*03:25; DRB1*03:26; DRB1*03:27; DRB1*03:28; DRB1*03:29; DRB1*03:30; DRB1*03:31;
    DRB1*03:32; DRB1*03:33; DRB1*03:34; DRB1*03:35; DRB1*03:36; DRB1*03:37; DRB1*03:38; DRB1*03:39; DRB1*03:40 and
    DRB1*03:41. The sequence shown is that of DRB1*03:01
    2B14_HUMAN, P13760: The following alleles of DRB1-4 are known: DRB1*04:01, DRB1*04:02, DRB1*04:03, DRB1*04:04,
    DRB1*04:05, DRB1*04:06, DRB1*04:07, DRB1*04:08, DRB1*04:09, DRB1*04:10, DRB1*04:11, DRB1*04:12, DRB1*04:13,
    DRB1*04:14, DRB1*04:15, DRB1*04:16, DRB1*04:17, DRB1*04:18, DRB1*04:19, DRB1*04:20, DRB1*04:21, DRB1*04:22,
    DRB1*04:23, DRB1*04:24, DRB1*04:25, DRB1*04:26, DRB1*04:27, DRB1*04:28, DRB1*04:29, DRB1*04:30, DRB1*04:31,
    DRB1*04:32, DRB1*04:33, DRB1*04:34, DRB1*04:35, DRB1*04:36, DRB1*04:37, DRB1*04:38, DRB1*04:39, DRB1*04:40,
    DRB1*04:41, DRB1*04:42, DRB1*04:43, DRB1*04:44, DRB1*04:45, DRB1*04:46, DRB1*04:47, DRB1*04:48, DRB1*04:49,
    DRB1*04:50, DRB1*04:51, DRB1*04:52, DRB1*04:53, DRB1*04:54, DRB1*04:55, DRB1*04:56, DRB1*04:57, DRB1*04:58,
    DRB1*04:59, DRB1*04:60, DRB1*04:61, DRB1*04:62, DRB1*04:63, DRB1*04:64, DRB1*04:65, DRB1*04:66, DRB1*04:67,
    DRB1*04:68, DRB1*04:69, DRB1*04:70, DRB1*04:71, DRB1*04:72, DRB1*04:73, DRB1*04:74, DRB1*04:75, DRB1*04:76,
    DRB1*04:77 and DRB1*04:78. The sequence shown is that of DRB1*04:01
    2B17_HUMAN, P13761: The following alleles of DRB1-7 are known: DRB1*07:01, DRB1*07:03, DRB1*07:04, DRB1*07:05,
    DRB1*07:06, DRB1*07:07, DRB1*07:08, DRB1*07:09, DRB1*07:11, DRB1*07:12, DRB1*07:13, DRB1*07:14, DRB1*07:15,
    DRB1*07:16 and DRB1*07:17. The sequence shown is that of DRB1*07:01
    2B17_HUMAN, P13761: Allele DRB1*07:01 is associated with persistent hepatitis C virus (HCV) infections [MIM:609532]
    2B18_HUMAN, Q30134: The following alleles of DRB1-8 are known: DRB1*08:01 (Dw8.1), DRB1*08:02 (Dw8.2; DRB1L), DRB1*08:03
    (Dw8.3); DRB1*08:04; DRB1*08:05, DRB1*08:06, DRB1*08:07, DRB1*08:08, DRB1*08:09, DRB1*08:10, DRB1*08:11,
    DRB1*08:12, DRB1*08:13, DRB1*08:14, DRB1*08:15, DRB1*08:16, DRB1*08:17, DRB1*08:18, DRB1*08:19, DRB1*08:20,
    DRB1*08:21, DRB1*08:22, DRB1*08:23, DRB1*08:24, DRB1*08:25, DRB1*08:26, DRB1*08:27, DRB1*08:28, DRB1*08:29,
    DRB1*08:30, DRB1*08:31, DRB1*08:32, DRB1*08:33, DRB1*08:34, DRB1*08:35 and DRB1*08:36. The sequence shown is that
    of DRB1*08:01
    2B19_HUMAN, Q9TQE0: The following alleles of DRB1-9 are known: DRB1*09:01, DRB1*09:02, DRB1*09:03, DRB1*09:04,
    DRB1*09:05, DRB1*09:06, DRB1*09:07 and DRB1*09:08. The sequence shown is that of DRB1*09:01
    2B1A_HUMAN, Q30167: The following alleles of DRB1-10 are known: DRB1*10:01; DRB1*10:02 and DRB1*10:03. The sequence
    shown is that of DRB1*10:01
    2B1B_HUMAN, P20039: The following alleles of DRB1-11 are known: DRB1*11:01, DRB1*11:03, DRB1*11:04, DRB1*11:05,
    DRB1*11:06, DRB1*11:07, DRB1*11:08, DRB1*11:09, DRB1*11:10, DRB1*11:11, DRB1*11:12, DRB1*11:13, DRB1*11:14,
    DRB1*11:15, DRB1*11:16, DRB1*11:17, DRB1*11:18, DRB1*11:19, DRB1*11:20, DRB1*11:21, DRB1*11:22, DRB1*11:23,
    DRB1*11:24, DRB1*11:25, DRB1*11:26, DRB1*11:27, DRB1*11:28, DRB1*11:29, DRB1*11:30, DRB1*11:31, DRB1*11:32,
    DRB1*11:33, DRB1*11:34, DRB1*11:35, DRB1*11:36, DRB1*11:37, DRB1*11:38, DRB1*11:39, DRB1*11:40, DRB1*11:41,
    DRB1*11:42, DRB1*11:43, DRB1*11:44, DRB1*11:45, DRB1*11:46, DRB1*11:47, DRB1*11:48, DRB1*11:49, DRB1*11:50,
    DRB1*11:51, DRB1*11:52, DRB1*11:53, DRB1*11:54, DRB1*11:55, DRB1*11:56, DRB1*11:57, DRB1*11:58, DRB1*11:59,
    DRB1*11:60, DRB1*11:61, DRB1*11:62, DRB1*11:63, DRB1*11:64, DRB1*11:65, DRB1*11:66, DRB1*11:67, DRB1*11:68,
    DRB1*11:69, DRB1*11:70 and DRB1*11:72. The sequence shown is that of DRB1*11:01
    2B1B_HUMAN, P20039: Allele DRB1*11:01 is associated with self-limiting hepatitis C virus (HCV) infections [MIM:609532]
    2B1C_HUMAN, Q95IE3: The following alleles of DRB1-12 are known: DRB1*12:01, DRB1*12:02, DRB1*12:03, DRB1*12:04,
    DRB1*12:05, DRB1*12:06, DRB1*12:07, DRB1*12:08, DRB1*12:09, DRB1*12:10, DRB1*12:11, DRB1*12:12, DRB1*12:13,
    DRB1*12:14, DRB1*12:15, DRB1*12:16, DRB1*12:17, DRB1*12:18 and DRB1*12:19. The sequence shown is that of
    DRB1*12:01
    2B1D_HUMAN, Q5Y7A7: The following alleles of DRB1-13 are known: DRB1*13:01, DRB1*13:02, DRB1*13:03, DRB1*13:04,
    DRB1*13:05, DRB1*13:06, DRB1*13:07, DRB1*13:08, DRB1*13:09, DRB1*13:10, DRB1*13:11, DRB1*13:12, DRB1*13:13,
    DRB1*13:14, DRB1*13:15, DRB1*13:16, DRB1*13:17, DRB1*13:18, DRB1*13:19, DRB1*13:20, DRB1*13:21, DRB1*13:22,
    DRB1*13:23, DRB1*13:24, DRB1*13:25, DRB1*13:26, DRB1*13:27, DRB1*13:28, DRB1*13:29, DRB1*13:30, DRB1*13:31,
    DRB1*13:32, DRB1*13:33, DRB1*13:34, DRB1*13:35, DRB1*13:36, DRB1*13:37, DRB1*13:38, DRB1*13:39, DRB1*13:40,
    DRB1*13:41, DRB1*13:42, DRB1*13:43, DRB1*13:44, DRB1*13:45, DRB1*13:46, DRB1*13:47, DRB1*13:48, DRB1*13:49,
    DRB1*13:50, DRB1*13:51, DRB1*13:52, DRB1*13:53, DRB1*13:54, DRB1*13:55, DRB1*13:56, DRB1*13:57, DRB1*13:58,
    DRB1*13:59, DRB1*13:60, DRB1*13:61, DRB1*13:62, DRB1*13:63, DRB1*13:64, DRB1*13:65, DRB1*13:66, DRB1*13:67,
    DRB1*13:68, DRB1*13:69, DRB1*13:70, DRB1*13:71, DRB1*13:72, DRB1*13:73, DRB1*13:74, DRB1*13:75, DRB1*13:76,
    DRB1*13:77, DRB1*13:78, DRB1*13:79, DRB1*13:80, DRB1*13:81, DRB1*13:82, DRB1*13:83, DRB1*13:84, DRB1*13:85,
    DRB1*13:86, DRB1*13:87 and DRB1*13:88. The sequence shown is that of DRB1*13:01
    2B1E_HUMAN, Q9GIY3: The following alleles of DRB1-14 are known: DRB1*14:01, DRB1*14:02, DRB1*14:03, DRB1*14:04,
    DRB1*14:05, DRB1*14:06, DRB1*14:07, DRB1*14:08, DRB1*14:09, DRB1*14:10, DRB1*14:11, DRB1*14:12, DRB1*14:13,
    DRB1*14:14, DRB1*14:15, DRB1*14:16, DRB1*14:17, DRB1*14:18, DRB1*14:19, DRB1*14:20, DRB1*14:21, DRB1*14:22,
    DRB1*14:23, DRB1*14:24, DRB1*14:25, DRB1*14:26, DRB1*14:27, DRB1*14:28, DRB1*14:29, DRB1*14:30, DRB1*14:31,
    DRB1*14:32, DRB1*14:33, DRB1*14:34, DRB1*14:35, DRB1*14:36, DRB1*14:37, DRB1*14:38, DRB1*14:39, DRB1*14:40,
    DRB1*14:41, DRB1*14:42, DRB1*14:43, DRB1*14:44, DRB1*14:45, DRB1*14:46, DRB1*14:47, DRB1*14:48, DRB1*14:49,
    DRB1*14:50, DRB1*14:51, DRB1*14:52, DRB1*14:53, DRB1*14:54, DRB1*14:55, DRB1*14:56, DRB1*14:57, DRB1*14:58,
    DRB1*14:59, DRB1*14:60, DRB1*14:61, DRB1*14:62, DRB1*14:63, DRB1*14:64, DRB1*14:65, DRB1*14:67, DRB1*14:68,
    DRB1*14:69, DRB1*14:70, DRB1*14:71, DRB1*14:72, DRB1*14:73, DRB1*14:74, DRB1*14:75, DRB1*14:76, DRB1*14:77,
    DRB1*14:78, DRB1*14:79, DRB1*14:80, DRB1*14:81, DRB1*14:82, DRB1*14:83, DRB1*14:84 and DRB1*14:85. The sequence
    shown is that of DRB1*14:01
    2B1F_HUMAN, P01911: The following alleles of DRB1-15 are known: DRB1*15:01, DRB1*15:02, DRB1*15:03, DRB1*15:04,
    DRB1*15:05, DRB1*15:06, DRB1*15:07, DRB1*15:08, DRB1*15:09, DRB1*15:10, DRB1*15:11, DRB1*15:12, DRB1*15:13,
    DRB1*15:14, DRB1*15:15, DRB1*15:16, DRB1*15:18, DRB1*15:19, DRB1*15:20, DRB1*15:21, DRB1*15:22, DRB1*15:23,
    DRB1*15:24, DRB1*15:25, DRB1*15:26, DRB1*15:27, DRB1*15:28, DRB1*15:29, DRB1*15:30, DRB1*15:31 and DRB1*15:32.
    The sequence shown is that of DRB1*15:01
    2B1G_HUMAN, Q29974: The following alleles of DRB1-16 are known: DRB1*16:01; DRB1*16:02; DRB1*16:03; DRB1*16:04;
    DRB1*16:05; DRB1*16:07; DRB1*16:08; DRB1*16:09; DRB1*16:10; DRB1*16:11 and DRB1*16:12. The sequence shown is that
    of DRB1*16:02


    Selected SNPs for HLA-DRB1 (see all 1470)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs719457571,2
    C--32546054(+) CTCTC-/AGAT  
            
    AGAAC
    3 -- ds50010--------
    rs412871501,2
    C--32546056(+) CTCAGA/GTAGAA 3 -- ds50014Minor allele frequency- G:0.30WA NA EA 360
    rs343302471,2
    C--32546057(+) TCAGA-/T/TAGA
            
    GAACA
    1 -- ds50010--------
    rs92696481,2
    C--32546060(+) GATAGC/AACATA 3 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs92696491,2
    C--32546067(+) CATAAT/CGGAGA 3 -- ds50011Minor allele frequency- C:0.00NA 2
    rs92696501,2
    C--32546068(+) ATAACG/AGAGAA 1 -- ds50011Minor allele frequency- A:0.00NA 2
    rs339255761,2
    C--32546073(+) GAGAA-/CTCC  
            
    CTCTC
    1 -- ds50010--------
    rs92696511,2
    C,F--32546074(+) GAGAAC/TTCTCC 1 -- ds50012Minor allele frequency- T:0.38NA MN 8
    rs92696521,2
    C,F--32546075(+) AGAACC/TCTCCA 1 -- ds50011Minor allele frequency- T:0.50MN 6
    rs356893431,2
    C--32546079(+) CTCTCC/TATCTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for HLA-DRB1 (32546546 - 32557625 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HLA-DRB1 (see all 91):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731847CNV Deletion23290073
    dgv1100e199CNV Deletion23128226
    esv2731848CNV Deletion23290073
    dgv1106e199CNV Deletion23128226
    dgv1108e199CNV Deletion23128226
    dgv1105e199CNV Deletion23128226
    esv2422111CNV Deletion20811451
    dgv1045e201CNV Deletion23290073
    esv2421657CNV Deletion20811451
    esv1128844CNV Insertion17803354

    Human Gene Mutation Database (HGMD): HLA-DRB1
    Locus Specific Mutation Databases (LSDB): HLA-DRB1

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing HLA-DRB1
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-DRB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 142857   
    OMIM disorders: 181000  126200  180300  
    UniProtKB/Swiss-Prot: 2B1G_HUMAN, Q29974
  • Sarcoidosis 1 (SS1) [MIM:181000]: An idiopathic, systemic, inflammatory disease characterized by the
    formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic
    system, but also skin, liver, spleen, eyes and other organs may be involved. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry

  • Selected diseases for HLA-DRB1 (see all 378):    
    About MalaCards
    bullous pemphigoid    rhizomelic pseudopolyarthritis    sarcoidosis 1    limited scleroderma
    pediatric systemic sclerosis    diffuse scleroderma    multiple sclerosis 1    rheumatoid arthritis
    narcolepsy    actinic prurigo    postherpetic neuralgia    halo nevi
    vogt-koyanagi-harada disease    pars planitis    kleine-levin syndrome    tubulointerstitial nephritis and uveitis
    focal epithelial hyperplasia    c4a deficiency    narcolepsy 1    small fiber neuropathy

    9 diseases from the University of Copenhagen DISEASES database for HLA-DRB1:
    Hypersensitivity reaction type II disease     Rheumatoid arthritis     Diabetes mellitus     Hyperthyroidism
    Connective tissue disease     Thyroiditis     Skin disease     Leprosy
    Multiple sclerosis

    HLA-DRB1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for HLA-DRB1 gene (see all 53)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rheumatoid arthritis 66.3 64 1416553 (3), 16277691 (2), 16385499 (2), 10765919 (2) (see all 44)
    genetic susceptibility 65.2 8 17055211 (1), 17047287 (1), 17309132 (1), 18004301 (1) (see all 8)
    polymyalgia rheumatica 58.1 10 10225816 (2), 8147928 (2), 9458210 (2), 15305244 (2) (see all 5)
    diabetes mellitus insulin-dependent 50.2 2 10680451 (1), 7817375 (1)
    autoimmune diseases 49.3 5 16362107 (1), 19117368 (1), 16198136 (1), 1617108 (1) (see all 5)
    vogt-koyanagi-harada disease 46.6 2 7906684 (1), 15603876 (1)
    autoimmunity 44.1 4 16385499 (1), 17987563 (1), 15120192 (1), 8675578 (1)
    hepatitis autoimmune 44 3 1350267 (2), 9672174 (1)
    pemphigus foliaceus 36.9 1 9027963 (1)
    diabetes autoimmune 35.6 2 10333055 (1), 18279373 (1)

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    PubMed articles for HLA-DRB1 gene, integrated from 10 sources (see all 2629) (see top 10):
    (articles sorted by number of sources associating them with HLA-DRB1)
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    1. [Determination of HLA-DRB1 gene polymorphism in Luoba ethnic group of Tibet]. (PubMed id 15898419)1, 4, 9 Kang L.L....Li S.B. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2005)
    2. Influence of HLA-DRB1 and TNF microsatellite polymorphisms on the expression of extraarticular manifestations in rheumatoid arthritis patients from northwest Spain. (PubMed id 11791643)1, 4, 9 Mattey D.L....Ollier W.E. (Clin. Exp. Rheumatol. 2001)
    3. Genetic variations of HLA-DRB1 and susceptibility to Kawasaki disease in Taiwanese children. (PubMed id 17207714)1, 4, 9 Huang F.Y....Lee Y.J. (Hum. Immunol. 2007)
    4. Pro-inflammatory variants of DRB1 and RAGE genes are associated with susceptibility to pediatric type 1 diabetes: a new hypothesis on the adaptive role of autoimmunity. (PubMed id 17987563)1, 4, 9 Damiani G....Cuccia M. (Riv. Biol. 2007)
    5. [Possible association between HLA-HRB1 and DQB1 genes frequency and susceptibility or resistance to Helicobacter pylori infection in Kunming Yi ethnic group children]. (PubMed id 15833172)1, 4, 9 Huang Y.K....Zhou L.F. (Zhonghua Er Ke Za Zhi 2005)
    6. HLA-DRB1 allele in 35 patients with alveolar echinococcosis in Gansu Province of China. (PubMed id 14570623)1, 4, 9 Li F....Craig P.S. (Chin. Med. J. 2003)
    7. The effect of HLA-DRB1 genes, rheumatoid factor, and treatment on radiographic disease progression in rheumatoid arthritis over 6 years. (PubMed id 11093435)1, 4, 9 Rau R....Fenner H. (J. Rheumatol. 2000)
    8. Role of HLA-DRB1 and PTPN22 genes in susceptibility to juvenile idiopathic arthritis in Hungarian patients. (PubMed id 19210888)1, 4, 9 PazA!r B....PoA^r G. (Clin. Exp. Rheumatol. 2008)
    9. [Gene and haplotype frequencies for the loci HLA-A, B and DRB1 in 11755 north Chinese Han bone marrow registry donors]. (PubMed id 17493347)1, 4, 9 Wu Q.J....Wei X.Q. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2007)
    10. [Polymorphism of human leukocyte antigen-A, B, and DRB1 genes in bone marrow registry donors of Shaanxi province analysis of 14 006 cases]. (PubMed id 17288808)1, 4, 9 Liu M.L....Liu S. (Zhonghua Yi Xue Za Zhi 2006)
    11. Polymorphism of HLA-DRB1 gene shows no strong association with ulcerative colitis in Chinese patients. (PubMed id 16426241)1, 4, 9 LA1 M. and Xia B. (Int. J. Immunogenet. 2006)
    12. [The role of HLA DRB1 genetic polymorphisms in non-Hodgkin's lymphomas]. (PubMed id 16786764)1, 4, 9 Kalinka E....Warzocha K. (Prz. Lek. 2005)
    13. HLA-DRB1 allele polymorphosm associated with susceptibility to leukemia in Han nationality of Gansu. (PubMed id 16277843)1, 4, 9 Cao H.X....Zhou L.X. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2005)
    14. HLA-DRB1 allele distribution in polymyalgia rheumatica and giant cell arteritis: influence on clinical subgroups and prognosis. (PubMed id 15305244)1, 4, 9 MartA-nez-Taboda V.M....Rodriguez-Valverde V. (Semin. Arthritis Rheum. 2004)
    15. [Association of HLA-A, B, and DR haplotypes with genotype in Chinese children with systemic lupus erythematosus]. (PubMed id 14748996)1, 4, 9 Li C.F....Jiang Z.F. (Zhonghua Er Ke Za Zhi 2003)
    16. [Polymorphism of length of tetranucleotide repeat from the 5'-side from the myelin basic protein gene in multiple sclerosis in Russians]. (PubMed id 14714495)1, 4, 9 AndreevskiA- T.V....Favorova O.O. (Mol. Biol. (Mosk.) 2003)
    17. HLA-DRB1 and HLA-DQB1 polymorphisms in Pacific Islands populations. (PubMed id 12144623)1, 4, 9 Velickovic Z.M....Carter J.M. (Tissue Antigens 2002)
    18. Collagenase-1 (MMP-1) and HLA-DRB1 gene polymorphisms in rheumatoid arthritis: a prospective longitudinal study. (PubMed id 11824952)1, 4, 9 Constantin A....Cantagrel A. (J. Rheumatol. 2002)
    19. MICA polymorphisms and haplotypes with HLA-B and HLA-DRB1 in Koreans. (PubMed id 19895570)1, 4, 9 Sohn Y.H....Kwon O.J. (Tissue Antigens 2010)
    20. Familial disease, the HLA-DRB1 shared epitope and anti-CCP antibodies influence time at appearance of substantial joint damage in rheumatoid arthritis. (PubMed id 19117726)1, 4, 9 Rojas-Villarraga A....Anaya J.M. (J. Autoimmun. 2009)
    21. Association study of CCR5 delta 32 polymorphism among the HLA-DRB1 Caucasian population in Northern ParanA!, Brazil. (PubMed id 18623133)1, 4, 9 Muxel S.M....Ehara Watanabe M.A. (J. Clin. Lab. Anal. 2008)
    22. Influence of HLA-DRB1 genes and the shared epitope on genetic susceptibility to rheumatoid arthritis in Taiwanese. (PubMed id 17309132)1, 4, 9 Liu S.C....Huang C.H. (J. Rheumatol. 2007)
    23. [HLA-A, B, DRB1 gene polymorphism of Beijing population was studied by high-resolution polymerase chain reaction sequence-based typing]. (PubMed id 16456803)1, 4, 9 Deng Y.J....Liu Y. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006)
    24. Association between protein tyrosine phosphatase 22 variant R620W in conjunction with the HLA-DRB1 shared epitope and humoral autoimmunity to an immunodominant epitope of cartilage-specific type II collagen in early rheumatoid arthritis. (PubMed id 16385499)1, 4, 9 Burkhardt H....Reis A. (Arthritis Rheum. 2006)
    25. [Polymorphism of HLA-A,-B and DRB1 in Han population of Shanxi province]. (PubMed id 16215957)1, 4, 9 Lan T....Wang G.Q. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005)
    26. Association of tumour necrosis factor-alpha, lymphotoxin-alpha and HLA-DRB1 gene polymorphisms with LAPfgren's syndrome in Czech patients with sarcoidosis. (PubMed id 15713215)1, 4, 9 Mrazek F....Petrek M. (Tissue Antigens 2005)
    27. The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis. (PubMed id 16277691)1, 4, 9 Turesson C....Matteson E.L. (amp 2005)
    28. Epistatic interactions between HLA-DRB1 and interleukin 4, but not interferon-gamma, increase susceptibility to giant cell arteritis. (PubMed id 15570643)1, 4, 9 Amoli M.M....Ollier W.E. (J. Rheumatol. 2004)
    29. Molecular analyses of HLA-DRB1, -DPB1, and -DQB1 in Jing ethnic minority of Southwest China. (PubMed id 12878363)1, 4, 9 Lin J.H....Xu A.L. (Hum. Immunol. 2003)
    30. HLA-DRB1 genes and disease severity in rheumatoid arthritis in Turkey. (PubMed id 14690140)1, 4, 9 Kinikli G....TokgAPz G. (Scand. J. Rheumatol. 2003)
    31. HLA-DRB1 genes and susceptibility to rheumatoid arthritis in three ethnic groups from Malaysia. (PubMed id 12482190)1, 4, 9 Kong K.F....Phipps M.E. (Autoimmunity 2002)
    32. HLA-DRB1 gene transcripts in rheumatoid arthritis. (PubMed id 11359453)1, 4, 9 Kerlan-Candon S....Eliaou J.F. (Clin. Exp. Immunol. 2001)
    33. Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis. (PubMed id 18832704)1, 4, 9 Caillier S.J....Oksenberg J.R. (J. Immunol. 2008)
    34. Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis. (PubMed id 18240242)1, 4, 9 Farragher T.M....Barton A. (Arthritis Rheum. 2008)
    35. A single tumour necrosis factor haplotype influences the response to adalimumab in rheumatoid arthritis. (PubMed id 17673491)1, 4, 9 Miceli-Richard C....Mariette X. (Ann. Rheum. Dis. 2008)
    36. The association between the genetic polymorphism of HLA-DQA1, DQB1, and DRB1 and serum alanine aminotransferase levels in chronic hepatitis C in the Chinese population. (PubMed id 18028350)1, 4, 9 Yu R.B....Ge D.F. (J. Gastroenterol. Hepatol. 2008)
    37. Meta-analysis of HLA-DRB1 and HLA-DQB1 polymorphisms in Latin American patients with systemic lupus erythematosus. (PubMed id 18295738)1, 4, 9 CastaA+o-RodrA-guez N....Anaya J.M. (Autoimmun Rev 2008)
    38. Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis. (PubMed id 18952831)1, 4, 9 Matsuoka T....Kira J. (Mult. Scler. 2008)
    39. Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: comparison with psoriasis and undifferentiated inflammatory arthritis. (PubMed id 17728335)1, 4, 9 Ho P.Y....Bruce I.N. (Ann. Rheum. Dis. 2008)
    40. Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis. (PubMed id 17876645)1, 4, 9 Furuya T....Kotake S. (Clin. Rheumatol. 2007)
    41. A second major histocompatibility complex susceptibility locus for multiple sclerosis. (PubMed id 17252545)1, 4, 9 Yeo T.W....Sawcer S. (Ann. Neurol. 2007)
    42. [Human leucocyte antigen gene (HLA-A, HLA-B, HLA-DRB1) frequencies in deceased organ donors]. (PubMed id 18320121)1, 4, 9 RodrA-guez L.M....GarcA-a L.F. (Biomedica 2007)
    43. Influence and interactions of cathepsin D, HLA-DRB1 and APOE on cognitive abilities in an older non-demented population. (PubMed id 16417614)1, 4, 9 Payton A....Pendleton N. (Genes Brain Behav. 2006)
    44. [HLA-DRB1 gene distribution in Croatian arthritis patients]. (PubMed id 16689106)1, 4, 9 ZerjaviA8 N.L....IvaniseviA8 G. (Reumatizam 2005)
    45. DRB1, DQA1, DQB1 genes in Turkish children with rheumatic fever. (PubMed id 15789899)1, 4, 9 Hallioglu O....Ozer S. (Clin. Exp. Rheumatol. 2005)
    46. Association between migraine and HLA-DRB1 gene polymorphisms. (PubMed id 16362659)1, 4, 9 Rainero I....Pinessi L. (J Headache Pain 2005)
    47. Polymorphisms of the HLA-B and HLA-DRB1 genes in Thai malaria patients. (PubMed id 15728986)1, 4, 9 Hananantachai H....Tokunaga K. (Jpn. J. Infect. Dis. 2005)
    48. DQB1*0602 allele shows a strong association with multiple sclerosis in patients in Malaga, Spain. (PubMed id 15083289)1, 4, 9 FernA!ndez O....de RamA^n E. (J. Neurol. 2004)
    49. A NOTCH4 association with multiple sclerosis is secondary to HLA-DR*1501. (PubMed id 14651518)1, 4, 9 Duvefelt K....Hillert J. (Tissue Antigens 2004)
    50. [The association of HLA-DRB1 allele polymorphism with the genetic susceptibility to liver cirrhosis due to hepatitis B virus]. (PubMed id 12778456)1, 4, 9 Cheng Y.Q....Xiong P. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2003)
    51. [Association between HLA-DRB1, DQB1 genes and pemphigus vulgaris in Chinese Hans]. (PubMed id 12579512)1, 4, 9 Zhou S.H....Ye S.Z. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2003)
    52. HLA class II and TNF genes in African Americans from the Southeastern United States: regional differences in allele frequencies. (PubMed id 12770797)1, 4, 9 Kuffner T....McNicholl J. (Hum. Immunol. 2003)
    53. Association of the HLA-DRB1 gene with susceptibility to aortoarteritis in a Chinese Han population. (PubMed id 12358152)1, 4, 9 Dang A....Liu L. (Hypertens. Res. 2002)
    54. Possible association of HLA-DRB1 gene with the autoantibody against myocardial mitochondria ADP/ATP carrier in dilated cardiomyopathy. (PubMed id 12658812)1, 4, 9 Wang Q....Zhang J. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2002)
    55. [Study on the relations between HLA-DRB1 alleles and idiopathic thrombocytopenic purpura in children]. (PubMed id 12170464)1, 4, 9 Wang H....Hou H. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2002)
    56. Association of DRB1*04-DQB1*0301 haplotype and lack of association of two polymorphic sites at CTLA-4 gene with Hashimoto's thyroiditis in an Italian population. (PubMed id 11288988)1, 4, 9 Petrone A....Buzzetti R. (Thyroid 2001)
    57. Association of HLA-DRB1(*)07 and DRB1(*)04 to citrus red mite (Panonychus citri) and house dust mite sensitive asthma. (PubMed id 11069565)1, 4, 9 Cho S.H....Min K.U. (Clin. Exp. Allergy 2000)
    58. Tumor necrosis factor, tumor necrosis factor receptors type 1 and 2, lymphotoxin-alpha, and HLA-DRB1 gene polymorphisms in human T-cell lymphotropic virus type I associated myelopathy. (PubMed id 11163081)1, 4, 9 Nishimura M....Uchiyama T. (Hum. Immunol. 2000)
    59. Association of HLA DRB1 alleles with juvenile idiopathic arthritis in Mexicans. (PubMed id 20346252)1, 4, 9 Silva-Ramirez B....Burgos-Vargas R. (Clin. Exp. Rheumatol. 2010)
    60. HLA-B, DR and DQ antigens polymorphism in Tunisian patients with ankylosing spondylitis (a case-control study). (PubMed id 19655145)1, 4, 9 Kchir M.M....Makni S. (Rheumatol. Int. 2010)
    61. Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex. (PubMed id 19295542)1, 4, 9 Viken M.K....Lie B.A. (Genes Immun. 2009)
    62. Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. (PubMed id 19143813)1, 4, 9 Howson J.M....Todd J.A. (amp 2009)
    63. HLA class II polymorphism in children with coeliac disease in Tunisia: is there any influence on clinical manifestation? (PubMed id 19474744)1, 4, 9 Laadhar L....Ben Hariz M. (amp 2009)
    64. Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis. (PubMed id 19333936)1, 4, 9 LundstrAPm E....Padyukov L. (Arthritis Rheum. 2009)
    65. TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole. (PubMed id 19374512)1, 4, 9 Alfirevic A....Pirmohamed M. (Pharmacogenomics 2009)
    66. Human leukocyte antigen (HLA)-B, DRB1, and DQB1 allotypes associated with disease and protection of trachoma endemic villagers. (PubMed id 18824733)1, 4, 9 Abbas M....West S.K. (amp 2009)
    67. Associations between genetic factors, tobacco smoking and autoantibodies in familial and sporadic rheumatoid arthritis. (PubMed id 17660221)1, 4, 9 Michou L....Petit-Teixeira E. (Ann. Rheum. Dis. 2008)
    68. [Expression and analysis of HLA-A, B and DRB1 genes in patients with chronic myelogenous leukemia in Guangdong area]. (PubMed id 18718089)1, 4, 9 Wei L....Chong F. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008)
    69. Independent association of tumor necrosis factor polymorphism with type 1 diabetes susceptibility. (PubMed id 19120272)1, 4, 9 Shin H.D....Park Y. (Ann. N. Y. Acad. Sci. 2008)
    70. HLA DRB1, DQB1 and insulin promoter VNTR polymorphisms: interactions and the association with adult-onset diabetes mellitus in Czech patients. (PubMed id 18279373)1, 4, 9 Cejkova P....Zdarsky E. (Int. J. Immunogenet. 2008)
    71. A suggestive association of fuchs heterochromic cyclitis with cytotoxic T cell antigen 4 gene polymorphism. (PubMed id 17287608)1, 4, 9 Spriewald B.M....Wenkel H. (Ophthalmic Res. 2007)
    72. Influence of human leucocyte antigen-DRB1 on the susceptibility to rheumatoid arthritis and on the production of anti-cyclic citrullinated peptide antibodies in a Portuguese population. (PubMed id 16793843)1, 4, 9 Ligeiro D....Branco J. (Ann. Rheum. Dis. 2007)
    73. Prevalence of HLA DQB1*0602 allele in patients with migraine. (PubMed id 18345414)1, 4, 9 Coelho F.M....Tufik S. (Arq Neuropsiquiatr 2007)
    74. HLA Dr-Dq haplotypes and the TNFA-308 polymorphism: associations with asthma and allergy. (PubMed id 17686102)1, 4, 9 Munthe-Kaas M.C....Undlien D. (Allergy 2007)
    75. MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility. (PubMed id 17003176)1, 4, 9 Lopez-Arbesu R.... Gonzalez S. (Rheumatology 2007)
    76. The association between HLA genes and radiological erosions in Malaysian patients with rheumatoid arthritis. (PubMed id 17453717)1, 4, 9 Yeap S.S....Phipps M.E. (Autoimmunity 2007)
    77. Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients. (PubMed id 17256150)1, 4, 9 Rubio J.P....Foote S.J. (Immunogenetics 2007)
    78. Three allele combinations associated with multiple sclerosis. (PubMed id 16872485)1, 4, 9 Favorova O.O....Ochs M.F. (BMC Med. Genet. 2006)
    79. MHC class II, tumour necrosis factor alpha, and lymphotoxin alpha gene haplotype associations with serological subsets of systemic lupus erythematosus. (PubMed id 16107511)1, 4, 9 McHugh N.J....Welsh K. (Ann. Rheum. Dis. 2006)
    80. Association of HLA class II DRB1, DPA1 and DPB1 polymorphism with genetic susceptibility to idiopathic dilated cardiomyopathy in Chinese Han nationality. (PubMed id 17060025)1, 4, 9 Liu W....Gan R.T. (Autoimmunity 2006)
    81. Association between the HLA-DRB1 gene and clinical features of systemic sclerosis in Korea. (PubMed id 16467040)1, 4, 9 Joung C.I....Yoo D.H. (Scand. J. Rheumatol. 2006)
    82. [Influence of alleles and haplotypes of the main histocompatibility complex on the susceptibility to systemic lupus erythematosus in the Mexican population]. (PubMed id 16875346)1, 4, 9 Granados J....Vargas-AlarcA^n G. (Gac Med Mex 2006)
    83. Association of HLA-DR, -DQ, and vitamin D receptor alleles and haplotypes with tuberculosis in the Venda of South Africa. (PubMed id 16916662)1, 4, 9 Lombard Z....Bornman L. (Hum. Immunol. 2006)
    84. Is the association between TNF-alpha-308 A allele and DMT1 independent of HLA-DRB1, DQB1 alleles? (PubMed id 17047287)1, 4, 9 Deja G....MaA8ecka-Tendera E. (Mediators Inflamm. 2006)
    85. HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma. (PubMed id 15902698)1, 4, 9 Dorak M.T....Kaslow R.A. (J. Med. Virol. 2005)
    86. Genetic predictors of coronary heart disease risk factors in premenopausal African-American women. (PubMed id 15825968)1, 4, 9 Giger J.N....Acton R.T. (amp 2005)
    87. Association of the major histocompatibility complex with response to infliximab therapy in rheumatoid arthritis patients. (PubMed id 15077289)1, 4, 9 Martinez A....Fernandez-Gutierrez B. (Arthritis Rheum. 2004)
    88. HLA-DRB1 and -DQB1 alleles in mestizo patients with Vogt-Koyanagi-Harada's disease in Southern California. (PubMed id 15603876)1, 4, 9 Levinson R.D....Holland G.N. (Hum. Immunol. 2004)
    89. [Study on the polymorphisme of human leucocyte antigen-DRB1, -DQA1 and -DQB1 alleles in patients with hepatitis B]. (PubMed id 15231205)1, 4, 9 Jiang Y.G. and Wang Y.M. (Zhonghua Liu Xing Bing Xue Za Zhi 2004)
    90. HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos. (PubMed id 15120191)1, 4, 9 Garavito G....Jaraquemada D. (Hum. Immunol. 2004)
    91. Heterogeneity in the magnitude of the insulin gene effect on HLA risk in type 1 diabetes. (PubMed id 15561961)1, 4, 9 Motzo C....Cucca F. (Diabetes 2004)
    92. Diabetes mellitus in adults: association of HLA DRB1 and DQB1 diabetes risk alleles with GADab presence and C-peptide secretion. (PubMed id 15388265)1, 4, 9 Novota P....Andel M. (Immunol. Lett. 2004)
    93. HLA class II typing in newborns reveals a low frequency of the DRB1*04 allele and a high frequency of DRB1*11 allele in three regions of continental Italy. (PubMed id 15120192)1, 4, 9 Galgani A....Buzzetti R. (Hum. Immunol. 2004)
    94. Analysis of major histocompatibility complex and CTLA-4 alleles in Brazilian patients with primary biliary cirrhosis. (PubMed id 12911663)1, 4, 9 Bittencourt P.L....Goldberg A.C. (J. Gastroenterol. Hepatol. 2003)
    95. Novel association of HLA-haplotypes with primary sclerosing cholangitis (PSC) in a southern European population. (PubMed id 14567462)1, 4, 9 Neri T.M....Okolicsanyi L. (Dig Liver Dis 2003)
    96. Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease. (PubMed id 14662898)1, 4, 9 Maier L.A....Newman L.S. (J. Immunol. 2003)
    97. [Polymorphism of human HLA-DRB1 leukocyte antigen alleles and its association to juvenile rheumatoid arthritis in a sample of Colombian mestizo children]. (PubMed id 14582328)1, 4, 9 Garavito G....Egea E. (Biomedica 2003)
    98. Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan. (PubMed id 12464650)1, 4, 9 Hildesheim A....Erlich H.A. (J. Natl. Cancer Inst. 2002)
    99. The association between tumor necrosis factor, HLA-DR alleles, and IgE-mediated asthma in Taiwanese adolescents. (PubMed id 12169181)1, 4, 9 Lin Y.C....Guo Y.L. (Allergy 2002)
    100. HLA associations in P. falciparum malaria patients from Mumbai, western India. (PubMed id 14686115)1, 4, 9 Shankarkumar U....Mohanty D. (Indian J Malariol 2002)
    101. HLA-DR and DQB1 gene polymorphism in the North-western Colombian population. (PubMed id 12144632)1, 4, 9 Correa P.A....Anaya J.M. (Tissue Antigens 2002)
    102. Molecular analysis of HLA-DRB1, DQA1, DQB1, DQ promoter polymorphism and extended class I/class II haplotypes in the Seri Indians from Northwest Mexico. (PubMed id 12144622)1, 4, 9 Alaez C....Gorodezky C. (Tissue Antigens 2002)
    103. Association analysis of HLA-class II and class III gene polymorphisms in the susceptibility to mediterranean visceral leishmaniasis. (PubMed id 11334675)1, 4, 9 Meddeb-Garnaoui A....Dellagi K. (Hum. Immunol. 2001)
    104. HLA class II alleles in Chinese patients with hepatocellular carcinoma. (PubMed id 11318984)1, 4, 9 Donaldson P.T....Johnson P.J. (Liver 2001)
    105. HLA class I and class II allele and haplotype diversity in Martinicans. (PubMed id 11285127)1, 4, 9 Bera O....Semana G. (Tissue Antigens 2001)
    106. Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-I^ therapy in multiple sclerosis patients. (PubMed id 21502966)1, 4 Weber F....Hemmer B. (Pharmacogenomics J. 2012)
    107. A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy. (PubMed id 22197929)1, 4 Yu X.Q....Liu J.J. (Nat. Genet. 2012)
    108. HLA-DRB1*0407 and *1304 are risk factors for scleroderma renal crisis. (PubMed id 21280007)1, 4 Nguyen B....Assassi S. (Arthritis Rheum. 2011)
    109. Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. (PubMed id 21779181)1, 4 Gorlova O....Martin J. (PLoS Genet. 2011)
    110. Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1. (PubMed id 20797713)1, 4 Sundqvist J....D'Hooghe T.M. (Fertil. Steril. 2011)
    111. HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease. (PubMed id 21699788)1, 4 Okada Y....Kubo M. (Gastroenterology 2011)
    112. Clinical and immunological differences between early and late-onset myasthenia gravis in Japan. (PubMed id 21074862)1, 4 Suzuki S....Suzuki N. (J. Neuroimmunol. 2011)
    113. HLA class II alleles and multiple sclerosis in Tunisian patients. (PubMed id 20691532)1, 4 Messadi A....Gritli N. (Clin Neurol Neurosurg 2010)
    114. Combined effects of smoking, anti-EBNA antibodies, and HLA-DRB1*1501 on multiple sclerosis risk. (PubMed id 20375311)1, 4 Simon K.C....Ascherio A. (Neurology 2010)
    115. Acquired haemophilia caused by non-haemophilic factor VIII gene variants. (PubMed id 20054547)1, 4 Tiede A....Ganser A. (Ann. Hematol. 2010)
    116. Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury. (PubMed id 20800921)1, 4 Donaldson P.T....Aithal G.P. (J. Hepatol. 2010)
    117. Molecular analysis of HLA Class I and Class II genes in four indigenous Malaysian populations. (PubMed id 20003135)1, 4 Jinam T.A....Phipps M.E. (Tissue Antigens 2010)
    118. The role of tumor necrosis factor alpha G-308A polymorphisms in the course of pulmonary sarcoidosis. (PubMed id 20070603)1, 4 Wijnen P.A....Drent M. (Tissue Antigens 2010)
    119. Haplotype analysis discriminates genetic risk for DR3-associated endocrine autoimmunity and helps define extreme risk for Addison's disease. (PubMed id 20631027)1, 4 Baker P.R....Eisenbarth G.S. (J. Clin. Endocrinol. Metab. 2010)
    120. Genetic association of htSNPs across the major histocompatibility complex with rheumatoid arthritis in an African-American population. (PubMed id 19741715)1, 4 Reynolds R.J....Bridges S.L. (Genes Immun. 2010)
    121. Frequency and impact of obstetric complications prior and subsequent to unexplained secondary recurrent miscarriage. (PubMed id 20395221)1, 4 Nielsen H.S....Christiansen O.B. (Hum. Reprod. 2010)
    122. Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk. (PubMed id 20233754)1, 4 Karlson E.W....Plenge R.M. (Ann. Rheum. Dis. 2010)
    123. HLA-Class II in Latin American patients with type 1 diabetes. (PubMed id 20561992)1, 4 Rojas-Villarraga A....Anaya J.M. (Autoimmun Rev 2010)
    124. Mold-sensitivity in children with moderate-severe asthma is associated with HLA-DR and HLA-DQ. (PubMed id 20486920)1, 4 Knutsen A.P....Shah M.R. (Allergy 2010)
    125. Leprosy and the adaptation of human toll-like receptor 1. (PubMed id 20617178)1, 4 Wong S.H....Vannberg F.O. (PLoS Pathog. 2010)
    126. A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. (PubMed id 20593013)1, 4 Cree B.A.... . (PLoS ONE 2010)
    127. Parent-of-origin effects at the major histocompatibility complex in multiple sclerosis. (PubMed id 20634196)1, 4 Chao M.J....Ebers G.C. (Hum. Mol. Genet. 2010)
    128. High frequency of the IL-2 -330 T/HLA-DRB1*1501 haplotype in patients with multiple sclerosis. (PubMed id 20594918)1, 4 Shahbazi M....Shahbazi S. (Clin. Immunol. 2010)
    129. HLA genotype in patients with acquired haemophilia A. (PubMed id 20536993)1, 4 Pavlova A....Oldenburg J. (Haemophilia 2010)
    130. [Immune polymorphism analysis of HLA class II antigens in ulcer diseases associated with Helicobacter pylori in children]. (PubMed id 20405713)1, 4 Nizhevich A.A....Tsyglintseva N.P. (amp 2010)
    131. Impact of highly conserved HLA haplotype on acute graft-versus-host disease. (PubMed id 20335219)1, 4 Morishima S....Morishima Y. (Blood 2010)
    132. Presence or absence of a known diabetic ketoacidosis precipitant defines distinct syndromes of &quot;A-I^+&quot; ketosis-prone diabetes based on long-term I^-cell function, human leukocyte antigen class II alleles, and sex predilection. (PubMed id 20170930)1, 4 Nalini R....Balasubramanyam A. (Metab. Clin. Exp. 2010)
    133. New classification of the shared epitope in rheumatoid arthritis: impact on the production of various anti-citrullinated protein antibodies. (PubMed id 19920092)1, 4 Gyetvai A....Lakos G. (Rheumatology (Oxford) 2010)
    134. HLA-DR genotypes influence age at disease onset in children and juveniles with type 1 diabetes mellitus. (PubMed id 20371654)1, 4 Awa W.L....Holl R.W. (Eur. J. Endocrinol. 2010)
    135. Immunogenetic characteristics of patients with autoimmune gastritis. (PubMed id 20082482)1, 4 Oksanen A.M....Partanen J.A. (World J. Gastroenterol. 2010)
    136. The type 1 diabetes - HLA susceptibility interactome--identification of HLA genotype-specific disease genes for type 1 diabetes. (PubMed id 20221424)1, 4 Brorsson C....Pociot F. (PLoS ONE 2010)
    137. Two HLA class I genes independently associated with multiple sclerosis. (PubMed id 20678810)1, 4 Link J....Brynedal B. (J. Neuroimmunol. 2010)
    138. Contribution of HLA-DRB1*04 alleles and anti-cyclic citrullinated antibodies to development of resistance to disease-modifying antirheumatic drugs in early rheumatoid arthritis. (PubMed id 20383728)1, 4 Mori S....Yonemura K. (Clin. Rheumatol. 2010)
    139. Diagnostic value of anti-cyclic citrullinated peptides and association with HLA-DRB1 shared epitope alleles in African rheumatoid arthritis patients. (PubMed id 20196860)1, 4 Singwe-Ngandeu M....Gabay C. (amp 2010)
    140. Cytotoxic T lymphocyte antigen-4 Ala17 polymorphism is a genetic marker of autoimmune adrenal insufficiency: Italian association study and meta-analysis of European studies. (PubMed id 19884265)1, 4 Brozzetti A....Falorni A. (Eur. J. Endocrinol. 2010)
    141. HLA has strongest association with IgA nephropathy in genome-wide analysis. (PubMed id 20595679)1, 4 Feehally J....Ratcliffe P.J. (J. Am. Soc. Nephrol. 2010)
    142. HLA association with nasopharyngeal carcinoma in southern Tunisia. (PubMed id 19714482)1, 4 Makni H....Frikha M. (Mol. Biol. Rep. 2010)
    143. Infectious mononucleosis-linked HLA class I single nucleotide polymorphism is associated with multiple sclerosis. (PubMed id 20736246)1, 4 Jafari N....Hintzen R.Q. (Mult. Scler. 2010)
    144. Relationship of type 1 diabetes to ancestral proportions and HLA DR/DQ alleles in a sample of the admixed Cuban population. (PubMed id 20569042)1, 4 Diaz-Horta O....Novoa L. (Ann. Hum. Biol. 2010)
    145. Association of HLA-A, -B and -DRB1 genotype with birthweight and CD34+ cell content: analysis of Korean newborns and their cord blood. (PubMed id 20154067)1, 4 Shin S....Roh E.Y. (Mol. Hum. Reprod. 2010)
    146. Clinical profile and HLA-DRB1 genotype of late onset multiple sclerosis in Western Australia. (PubMed id 20580995)1, 4 Qiu W....Kermode A.G. (J Clin Neurosci 2010)
    147. Association of HLA-DRB1*0405 with resistance to multibacillary leprosy in Taiwanese. (PubMed id 20353806)1, 4 Hsieh N.K....Lin M. (Hum. Immunol. 2010)
    148. Refining the association of MHC with multiple sclerosis in African Americans. (PubMed id 20466734)1, 4 McElroy J.P....Gourraud P.A. (Hum. Mol. Genet. 2010)
    149. HLA-DRB1*1501 intensifies the impact of IL-6 promoter polymorphism on the susceptibility to multiple sclerosis in an Iranian population. (PubMed id 20685768)1, 4 Shahbazi M....Rashidbaghan A. (Mult. Scler. 2010)
    150. Association analysis about HLA-DRB1, -DQB1 polymorphism and auto-antibodies against I+(1)-adrenergic receptors in Chinese patients with essential hypertension. (PubMed id 21091360)1, 4 Sun Y....Liao Y. (Clin. Exp. Hypertens. 2010)
    151. Analysis of maternal-offspring HLA compatibility, parent-of-origin effects, and noninherited maternal antigen effects for HLA-DRB1 in systemic lupus erythematosus. (PubMed id 20191587)1, 4 Bronson P.G....Barcellos L.F. (Arthritis Rheum. 2010)
    152. Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese. (PubMed id 20235791)1, 4 Hung S.I....Chen Y.T. (Pharmacogenomics 2010)
    153. Relatedness and HLA-DRB1 typing may discriminate the magnitude of the genetic susceptibility to tuberculosis using a household contact model. (PubMed id 19692729)1, 4 Lucena-Silva N....de Albuquerque M.d. (J Epidemiol Community Health 2010)
    154. Human leukocyte antigen alleles and the response to pegylated interferon/ribavirin therapy in chronic hepatitis C patients. (PubMed id 19931565)1, 4 Dai C.Y....Yu M.L. (Antiviral Res. 2010)
    155. Cancer-associated myositis and anti-p155 autoantibody in a series of 85 patients with idiopathic inflammatory myopathy. (PubMed id 20075704)1, 4 Trallero-AraguA!s E....Vilardell-TarrAcs M. (Medicine (Baltimore) 2010)
    156. Genetic associations in Italian primary sclerosing cholangitis: heterogeneity across Europe defines a critical role for HLA-C. (PubMed id 20347497)1, 4 Hov J.R....Invernizzi P. (J. Hepatol. 2010)
    157. The beneficial impact of missing KIR ligands and absence of donor KIR2DS3 gene on outcome following unrelated hematopoietic SCT for myeloid leukemia in the Chinese population. (PubMed id 20173784)1, 4 Wu G.Q....Huang H. (Bone Marrow Transplant. 2010)
    158. Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis. (PubMed id 20453840)1, 4 Sanna S....Cucca F. (Nat. Genet. 2010)
    159. Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients. (PubMed id 20187937)1, 4 Grunewald J....Eklund A. (Respir. Res. 2010)
    160. Human leukocyte antigen type and progression from onset of symptoms to development of asthma. (PubMed id 20214848)1, 4 Martyn M.B....Juhn Y.J. (Allergy Asthma Proc 2010)
    161. Allergic women show reduced T helper type 1 alloresponses to fetal human leucocyte antigen mismatch during pregnancy. (PubMed id 19860744)1, 4 Prescott S.L....Christiansen F.T. (Clin. Exp. Immunol. 2010)
    162. Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis. (PubMed id 19151010)1, 4 Karlson E.W....Costenbader K.H. (Ann. Rheum. Dis. 2010)
    163. Human leucocyte antigen class II DRB1 and DQB1 associations in human immunodeficiency virus-infected patients of Mumbai, India. (PubMed id 20345872)1, 4 Shankarkumar U....Pazare A. (Int. J. Immunogenet. 2010)
    164. Variation within DNA repair pathway genes and risk of multiple sclerosis. (PubMed id 20522537)1, 4 Briggs F.B....Barcellos L.F. (Am. J. Epidemiol. 2010)
    165. [Clinical and epidemiological features and HLA association in patients with pars planitis]. (PubMed id 20537664)1, 4 Mantrana-Bermejo M.E....SA!nchez-RomA!n J. (Med Clin (Barc) 2010)
    166. Epistasis between HLA-DRB1 parental alleles in a Spanish cohort with multiple sclerosis. (PubMed id 20810130)1, 4 Romero-Pinel L....Arbizu T. (J. Neurol. Sci. 2010)
    167. Association of killer cell immunoglobulin-like receptors and human leukocyte antigen-C genotypes in South Brazilian with type 1 diabetes. (PubMed id 20580654)1, 4 Jobim M....Schwartsmann G. (Hum. Immunol. 2010)
    168. A functional RANKL polymorphism associated with younger age at onset of rheumatoid arthritis. (PubMed id 20533289)1, 4 Tan W....Tsao B.P. (Arthritis Rheum. 2010)
    169. The impact of pregnancy on rheumatoid arthritis outcome: the role of maternofetal HLA class II disparity. (PubMed id 20031464)1, 4 Zrour S.H....Bergaoui N. (Joint Bone Spine 2010)
    170. Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort. (PubMed id 20353580)1, 4 Morgan A.W.... . (amp 2010)
    171. Genetic heterogeneity in latent autoimmune diabetes is linked to various degrees of autoimmune activity: results from the Nord-TrA,ndelag Health Study. (PubMed id 19833889)1, 4 Pettersen E....Grill V. (Diabetes 2010)
    172. Patient HLA-DRB1* and -DQB1* allele and haplotype association with hepatitis C virus persistence and clearance. (PubMed id 20392899)1, 4 Ali L....Khan K.M. (J. Gen. Virol. 2010)
    173. IgA deficiency and the MHC: assessment of relative risk and microheterogeneity within the HLA A1 B8, DR3 (8.1) haplotype. (PubMed id 19834793)1, 4 Mohammadi J....HammarstrAPm L. (J. Clin. Immunol. 2010)
    174. Polymorphisms in the genes encoding TGF-beta1, TNF-alpha, and IL-6 show association with type 1 diabetes mellitus in the Slovak population. (PubMed id 20686866)1, 4 Javor J....Buc M. (Arch. Immunol. Ther. Exp. (Warsz.) 2010)
    175. A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis. (PubMed id 21049023)1, 4 Field J....Stankovich J. (PLoS ONE 2010)
    176. Peanut-allergic subjects and their peanut-tolerant siblings have large differences in peanut-specific IgG that are independent of HLA class II. (PubMed id 20850383)1, 4 Dreskin S.C....Freed B.M. (Clin. Immunol. 2010)
    177. Effect of human leukocyte antigen homozygosity on rubella vaccine-induced humoral and cell-mediated immune responses. (PubMed id 19896518)1, 4 Kennedy R.B....Poland G.A. (Hum. Immunol. 2010)
    178. HLA class II alleles and haplotypes in Lithuanian children with type 1 diabetes and healthy children (HLA and type 1 diabetes). (PubMed id 20966625)1, 4 SkrodenienA9 E....Ludvigsson J. (Medicina (Kaunas) 2010)
    179. Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. (PubMed id 20694011)1, 4 Ferreira R.C....HammarstrAPm L. (Nat. Genet. 2010)
    180. Association between HLA-B*4001 and lipodystrophy among HIV-infected patients from Thailand who received a stavudine-containing antiretroviral regimen. (PubMed id 20073992)1, 4 Wangsomboonsiri W....Sungkanuparph S. (Clin. Infect. Dis. 2010)
    181. Analysis of HLA-A, HLA-B and HLA-DRB1 alleles in Chinese patients with lung cancer. (PubMed id 20449807)1, 4 Yang L....Xu S.F. (Genet. Mol. Res. 2010)
    182. Associations of cigarette smoking with rheumatoid arthritis in African Americans. (PubMed id 20722010)1, 4 Mikuls T.R....Bridges S.L. (Arthritis Rheum. 2010)
    183. HLA-DRB1 as a risk factor in children with autoimmune hepatitis and its relation to hepatitis A infection. (PubMed id 21067577)1, 4 Elfaramawy A.A....Aziz H.M. (Ital J Pediatr 2010)
    184. Sarcoidosis HLA class II genotyping distinguishes differences of clinical phenotype across ethnic groups. (PubMed id 20685690)1, 4 Sato H....Welsh K.I. (Hum. Mol. Genet. 2010)
    185. Association of human leukocyte antigen class II alleles with response to immunosuppressive therapy in Korean aplastic anemia patients. (PubMed id 19819281)1, 4 Song E.Y....Park M.H. (Hum. Immunol. 2010)
    186. Estimation of genetic risk for Type 1 diabetes mellitus in newborns on dried blood spot. (PubMed id 20101097)1, 4 Giannattasio A....d'Annunzio G. (J. Endocrinol. Invest. 2010)
    187. Specific human leukocyte antigen class I and II alleles associated with hepatitis C virus viremia. (PubMed id 20169624)1, 4 Kuniholm M.H....Carrington M. (Hepatology 2010)
    188. A shared HLA-DRB1 epitope in the DR beta first domain is associated with Vogt-Koyanagi-Harada syndrome in Indian patients. (PubMed id 20216938)1, 4 Tiercy J.M....Baglivo E. (Mol. Vis. 2010)
    189. Multiple sclerosis risk markers in HLA-DRA, HLA-C, and IFNG genes are associated with sex-specific childhood leukemia risk. (PubMed id 21067287)1, 4 Morrison B.A....Dorak M.T. (Autoimmunity 2010)
    190. Number of autoantibodies and HLA genotype, more than high titers of glutamic acid decarboxylase autoantibodies, predict insulin dependence in latent autoimmune diabetes of adults. (PubMed id 20603341)1, 4 Maioli M....Cucca F. (Eur. J. Endocrinol. 2010)
    191. Influence of HLA-DRB1 alleles on the susceptibility and resistance to multiple sclerosis in Japanese patients with respect to anti-aquaporin 4 antibody status. (PubMed id 20028711)1, 4 Isobe N....Kira J. (Mult. Scler. 2010)
    192. HLA-DRB1*11: a strong risk factor for acquired severe ADAMTS13 deficiency-related idiopathic thrombotic thrombocytopenic purpura in Caucasians. (PubMed id 20141578)1, 4 Coppo P....Loiseau P. (J. Thromb. Haemost. 2010)
    193. MSH5 is not a genetic predisposing factor for immunoglobulin A deficiency but marks the HLA-DRB1*0102 subgroup carrying susceptibility. (PubMed id 20542071)1, 4 Pozo N.D....NA_A+ez C. (Hum. Immunol. 2010)
    194. Nonmyeloablative HLA-haploidentical bone marrow transplantation with high-dose posttransplantation cyclophosphamide: effect of HLA disparity on outcome. (PubMed id 19925877)1, 4 Kasamon Y.L....Fuchs E.J. (Biol. Blood Marrow Transplant. 2010)
    195. HLA-A, -B, -DRB1 alleles and haplotypes frequencies in Moroccan patients with leukemia. (PubMed id 20478772)1, 4 Kabbaj M....Hassar M. (Ann. Biol. Clin. (Paris) 2010)
    196. CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. (PubMed id 20211854)1, 4 Bronson P.G....Barcellos L.F. (Hum. Mol. Genet. 2010)
    197. Effect of HLA class I and class II alleles on progression from autoantibody positivity to overt type 1 diabetes in children with risk-associated class II genotypes. (PubMed id 20739684)1, 4 Lipponen K....Ilonen J. (Diabetes 2010)
    198. Human leukocyte antigen-DR15, low infant sibling exposure and multiple sclerosis: gene-environment interaction. (PubMed id 20225292)1, 4 van der Mei I.A....Dwyer T. (Ann. Neurol. 2010)
    199. Diverging effects of HLA-DPB1 matching status on outcome following unrelated donor transplantation depending on disease stage and the degree of matching for other HLA alleles. (PubMed id 19924143)1, 4 Shaw B.E....Madrigal J.A. (Leukemia 2010)
    200. Presence of CSF oligoclonal bands (OCB) is associated with the HLA-DRB1 genotype in a West Australian multiple sclerosis cohort. (PubMed id 19879597)1, 4 Wu J.S....Kermode A.G. (J. Neurol. Sci. 2010)
    201. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. (PubMed id 20711174)1, 4 Hor H....Tafti M. (Nat. Genet. 2010)
    202. Visual hallucinations and HLA class II antigens in cortical dementia. (PubMed id 20606439)1, 4 GA^mez-Tortosa E....CA!rdaba B. (Dement Geriatr Cogn Disord 2010)
    203. HLA-DRB1*1501 tagging rs3135388 polymorphism is not associated with neuromyelitis optica. (PubMed id 20591987)1, 4 Matiello M....Weinshenker B.G. (Mult. Scler. 2010)
    204. Influence of female hormonal factors, in relation to autoantibodies and genetic markers, on the development of rheumatoid arthritis in northern Sweden: a case-control study. (PubMed id 20560812)1, 4 Berglin E....RantapAoAo Dahlqvist S. (Scand. J. Rheumatol. 2010)
    205. HLA-DR association in papillary thyroid carcinoma. (PubMed id 20164547)1, 4 Amoli M.M....Bazzaz J.T. (Dis. Markers 2010)
    206. Common vaccinations among adults do not increase the risk of developing rheumatoid arthritis: results from the Swedish EIRA study. (PubMed id 20603497)1, 4 Bengtsson C....Alfredsson L. (Ann. Rheum. Dis. 2010)
    207. Multiple sclerosis susceptibility alleles in African Americans. (PubMed id 19865102)1, 4 Johnson B.A....Oksenberg J.R. (Genes Immun. 2010)
    208. Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls. (PubMed id 19596691)1, 4 Arnett F.C....Reveille J.D. (Ann. Rheum. Dis. 2010)
    209. HLA class II polymorphism in Latin American patients with multiple sclerosis. (PubMed id 19896562)1, 4 Rojas O.L....Anaya J.M. (Autoimmun Rev 2010)
    210. HLA-DRB1*15, low infant sibling exposure, and multiple sclerosis gene-environment interaction. (PubMed id 20437569)1, 4 Ramagopalan S.V....Ebers G.C. (Ann. Neurol. 2010)
    211. Dissection of the FCGR3A association with RA: increased association in men and with autoantibody positive disease. (PubMed id 19700393)1, 4 Robinson J.I....Morgan A.W. (Ann. Rheum. Dis. 2010)
    212. Human leukocyte antigen (HLA) A1-B8-DR3 (8.1) haplotype, tumor necrosis factor (TNF) G-308A, and risk of non-Hodgkin lymphoma. (PubMed id 20147981)1, 4 Abdou A.M....Wang S.S. (Leukemia 2010)
    213. Genetic variants in the prediction of rheumatoid arthritis. (PubMed id 20439292)1, 4 van der Helm-van Mil A.H....Huizinga T.W. (Ann. Rheum. Dis. 2010)
    214. Association of human leukocyte antigen class II alleles with pemphigus vulgaris in a Turkish population. (PubMed id 20507388)1, 4 Tunca M....Akar A. (J. Dermatol. 2010)
    215. HLA-DRB1*01 allele and low plasma immunoglobulin G1 concentration may predispose to herpes-associated recurrent lymphocytic meningitis. (PubMed id 19879913)1, 4 Kallio-Laine K....Lokki M.L. (Hum. Immunol. 2010)
    216. Major histocompatibility complex class II transactivator gene polymorphism: associations with LAPfgren's syndrome. (PubMed id 20230522)1, 4 Grunewald J....Padyukov L. (Tissue Antigens 2010)
    217. Polymorphism located in TCRA locus confers susceptibility to essential hypersomnia with HLA-DRB1*1501-DQB1*0602 haplotype. (PubMed id 19927159)1, 4 Miyagawa T....Tokunaga K. (J. Hum. Genet. 2010)
    218. Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects. (PubMed id 20191588)1, 4 Hollenbach J.A....Glass D.N. (Arthritis Rheum. 2010)
    219. Prediction of radiographic progression in rheumatoid arthritis and the role of antibodies against mutated citrullinated vimentin: results from a 10-year prospective study. (PubMed id 19648126)1, 4 Syversen S.W....Kvien T.K. (Ann. Rheum. Dis. 2010)
    220. Association of IL4R single-nucleotide polymorphisms with rheumatoid nodules in African Americans with rheumatoid arthritis. (PubMed id 20444266)1, 4 Burgos P.I....Bridges S.L. (amp 2010)
    221. HLA status in patients with chronic spontaneous urticaria. (PubMed id 20559009)1, 4 Bozek A....Jarzab J. (Int. Arch. Allergy Immunol. 2010)
    222. Genetic aspect of venom allergy: association with HLA class I and class II antigens. (PubMed id 20684489)1, 4 Karakis G.P....Misirligil Z. (Ann Agric Environ Med 2010)
    223. Characterization of tumor necrosis factor-I+ block haplotypes associated with susceptibility to chronic venous leg ulcers in Caucasian patients. (PubMed id 20854863)1, 4 Tan J.H....Wallace H.J. (Hum. Immunol. 2010)
    224. Correlation of molecular human leukocyte antigen typing and outcome in high-risk melanoma patients receiving adjuvant interferon. (PubMed id 20549830)1, 4 Gogas H....Spyropoulou-Vlachou M. (Cancer 2010)
    225. The impact of anti-HY responses on outcome in current and subsequent pregnancies of patients with recurrent pregnancy losses. (PubMed id 20307907)1, 4 Christiansen O.B....Nielsen H.S. (J. Reprod. Immunol. 2010)
    226. HLA class II alleles: susceptibility or resistance to cystic echinococcosis in Yemeni patients. (PubMed id 20424860)1, 4 Al-Ghoury A.B....Rayan H.Z. (Parasitol. Res. 2010)
    227. Genetic markers in acquired haemophilia. (PubMed id 20586801)1, 4 Oldenburg J....Pavlova A. (Haemophilia 2010)
    228. Human leukocyte antigen typing in tuberculous rheumatism: Poncet's disease. (PubMed id 20550778)1, 4 Lugo-Zamudio G.E....Granados J. (Int. J. Tuberc. Lung Dis. 2010)
    229. An assessment of the association between childhood asthma and HLA DRB1*03 using extended haplotype analysis. (PubMed id 20735759)1, 4 Hanchard N.A....Juhn Y.J. (Tissue Antigens 2010)
    230. HLA-DRB1 allele heterogeneity influences multiple sclerosis severity as well as risk in Western Australia. (PubMed id 20006387)1, 4 Wu J.S....Kermode A.G. (J. Neuroimmunol. 2010)
    231. Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor. (PubMed id 20370905)1, 4 Balsa A....Pascual-Salcedo D. (amp 2010)
    232. HLA-DRB association in neuromyelitis optica is different from that observed in multiple sclerosis. (PubMed id 19995845)1, 4 Brum D.G....Donadi E.A. (Mult. Scler. 2010)
    233. Shared molecular amino acid signature in the HLA-DR peptide binding pocket predisposes to both autoimmune diabetes and thyroiditis. (PubMed id 20837527)1, 4 Menconi F....Tomer Y. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    234. Human leukocyte antigen association in idiopathic thrombotic thrombocytopenic purpura: evidence for an immunogenetic link. (PubMed id 19922436)1, 4 Scully M....Machin S. (J. Thromb. Haemost. 2010)
    235. Impact of amino acid substitution at residue 9 of HLA-A2 on the development of acute GVHD in Korean pediatric patients receiving unrelated hematopoietic stem cell transplantation. (PubMed id 20536911)1, 4 Hwang S.H....Lee E.Y. (Transpl. Int. 2010)
    236. Association of HLA-DRB1* and keloid disease in an Afro-Caribbean population. (PubMed id 19874322)1, 4 Brown J.J....Bayat A. (Clin. Exp. Dermatol. 2010)
    237. Influence of HLA-DRB1 allele heterogeneity on disease risk and clinical course in a West Australian MS cohort: a high-resolution genotyping study. (PubMed id 20207784)1, 4 Wu J.S....Kermode A.G. (Mult. Scler. 2010)
    238. Hormonal replacement therapy may reduce the risk for RA in women with early arthritis who carry HLA-DRB1 *01 and/or *04 alleles by protecting against the production of anti-CCP: results from the ESPOIR cohort. (PubMed id 19740903)1, 4 Salliot C....Dougados M. (Ann. Rheum. Dis. 2010)
    239. Opposing effects of the HLA-DRB1*0301-DQB1*0201 haplotype on the risk for multiple sclerosis in diverse Arab populations in Israel. (PubMed id 20463743)1, 4 Benedek G....Miller A. (Genes Immun. 2010)
    240. Molecular identification of the HLA-DRB1-DQB1 for diagnosis and follow-up of acute leukemias. (PubMed id 20051322)1, 4 Fernandes T.A....Kraemer M.H. (amp 2010)
    241. Human leukocyte antigen (HLA) and single nucleotide polymorphisms (SNPs) tumor necrosis factor (TNF)-alpha -238 and -308 as genetic markers of susceptibility to psoriasis and severity of the disease in a long-term follow-up Brazilian study. (PubMed id 20931685)1, 4 MagalhALes R.F....Kraemer M.H. (Int. J. Dermatol. 2010)
    242. HLA DR-DQ combination associated with the increased risk of developing human HCV positive non-Hodgkin's lymphoma is related to the type II mixed cryoglobulinemia. (PubMed id 20002609)1, 4 De Re V....Toffoli G. (Tissue Antigens 2010)
    243. HLA-DRB1 alleles are associated with the clinical course of disease and steroid dependence in Mexican patients with ulcerative colitis. (PubMed id 19674023)1, 4 Yamamoto-Furusho J.K....Granados J. (Colorectal Dis 2010)
    244. Human leukocyte antigens and HIV type 1 viral load in early and chronic infection: predominance of evolving relationships. (PubMed id 20224785)1, 4 Tang J....Kaslow R.A. (PLoS ONE 2010)
    245. Genetic and diabetic auto-antibody markers in Saudi children with type 1 diabetes. (PubMed id 20858521)1, 4 Manan H....Sitelbanat A. (Hum. Immunol. 2010)
    246. Contribution of anti-CCP antibodies, proximal interphalangeal joint involvement, HLA-DRB1 shared epitope, and PADI4 as risk factors for the development of rheumatoid arthritis in palindromic rheumatism. (PubMed id 20476860)1, 4 Tamai M....Eguchi K. (Scand. J. Rheumatol. 2010)
    247. Peptidyl arginine deiminase type IV (PADI4) haplotypes interact with shared epitope regardless of anti-cyclic citrullinated peptide antibody or erosive joint status in rheumatoid arthritis: a case control study. (PubMed id 20537173)1, 4 Bang S.Y....Kang C. (amp 2010)
    248. Association of HLA haplotypes with paroxysmal nocturnal hemoglobinuria. (PubMed id 20970669)1, 4 Nowak J....Zupanska B. (Transplant. Proc. 2010)
    249. Modifying effects of HLA-DRB1 allele interactions on age at onset of multiple sclerosis in Western Australia. (PubMed id 19995849)1, 4 Wu J.S....Kermode A.G. (Mult. Scler. 2010)
    250. Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA-DRB1 shared epitope, regardless of rheumatoid factor or anti-cyclic citrullinated peptide antibody status. (PubMed id 20112396)1, 4 Bang S.Y....Bae S.C. (Arthritis Rheum. 2010)
    251. Experimental and clinical characteristics in myelodysplastic syndrome patients with or without HLA-DR15 allele. (PubMed id 19593744)1, 4 Xiao L....Quan P. (Hematol Oncol 2010)
    252. [HLA-DRB1 allelic polymorphism in children with juvenile idiopathic arthritis]. (PubMed id 20497637)1, 4 Wu J. and Zeng H.S. (Zhongguo Dang Dai Er Ke Za Zhi 2010)
    253. Does pregnancy provide vaccine-like protection against rheumatoid arthritis? (PubMed id 20309863)1, 4 Guthrie K.A....Nelson J.L. (Arthritis Rheum. 2010)
    254. Type 1 diabetes and LADA--occurrence of HLA-DRB1 *03 and DRB1 *04 alleles in two age different groups of diabetics. (PubMed id 21033293)1, 4 Weber P....Cerna M. (Adv Gerontol 2010)
    255. Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis. (PubMed id 19861144)1, 4 Bonagura V.R....Rajalingam R. (Hum. Immunol. 2010)
    256. Effect of human leukocyte antigen class II genes on acute-onset and slow-onset type 1 diabetes in the Japanese population. (PubMed id 20510319)1, 4 Katahira M....Yasuda Y. (Hum. Immunol. 2010)
    257. HLA-DRB1*0901 lowers anti-cyclic citrullinated peptide antibody levels in Japanese patients with rheumatoid arthritis. (PubMed id 19854714)1, 4 Okada Y....Yamamoto K. (Ann. Rheum. Dis. 2010)
    258. HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes. (PubMed id 20547426)1, 4 de Graaf M.T....Smitt P.A. (J. Neuroimmunol. 2010)
    259. Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. (PubMed id 19865101)1, 4 Ockinger J....Olsson T. (Genes Immun. 2010)
    260. HLA genotyping in the international Type 1 Diabetes Genetics Consortium. (PubMed id 20595243)1, 4 Mychaleckyj J.C....Erlich H.A. (Clin Trials 2010)
    261. HLA class I and class II HLA DRB profiles in Egyptian children with rheumatic valvular disease. (PubMed id 20145915)1, 4 El-Hagrassy N....Joseph N. (Pediatr Cardiol 2010)
    262. Low level of systemic autoimmunity in Western Australian multiple sclerosis patients. (PubMed id 20150397)1, 4 Wei Qiu ....Kermode A.G. (Mult. Scler. 2010)
    263. Capture of type 1 diabetes-susceptible HLA DR-DQ haplotypes in Japanese subjects using a tag single nucleotide polymorphism. (PubMed id 19837788)1, 4 Nakanishi K. and Shima Y. (Diabetes Care 2010)
    264. Absence of consistent association between human leukocyte antigen-I and -II alleles and human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis risk in an HTLV-1 French Afro-Caribbean population. (PubMed id 20851016)1, 4 Deschamps R....Olindo S. (Int. J. Infect. Dis. 2010)
    265. Genotyping HLA-DRB1 and HLA-DQB1 alleles in Japanese patients with normal tension glaucoma. (PubMed id 21031025)1, 4 Suzuki M....Mizuki N. (Mol. Vis. 2010)
    266. Evidence for interaction between 5-hydroxytryptamine (serotonin) receptor 2A and MHC type II molecules in the development of rheumatoid arthritis. (PubMed id 20179740)1, 4 Seddighzadeh M....Padyukov L. (Eur. J. Hum. Genet. 2010)
    267. Association of HLA-A, -B, and -DRB1 with pulmonary tuberculosis in western Javanese Indonesia. (PubMed id 20438789)1, 4 Yuliwulandari R....Tokunaga K. (Hum. Immunol. 2010)
    268. Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology. (PubMed id 20385791)1, 4 Wang S.S....Carrington M. (Blood 2010)
    269. HLA-DRB1*15 confers susceptibility to juvenile SLE but is not associated with disease presentation: an Egyptian Study. (PubMed id 20380521)1, 4 Mosaad Y.M....Elhanbly S. (Immunol. Invest. 2010)
    270. Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African Americans. (PubMed id 20237121)1, 4 Kelley J.M....Bridges S.L. (Ann. Rheum. Dis. 2010)
    271. HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium. (PubMed id 20798335)1, 4 Noble J.A....Erlich H.A. (Diabetes 2010)
    272. Distribution of HLA-DRB1 alleles in Argentinean patients with Chagas' disease cardiomyopathy. (PubMed id 19811437)1, 4 GarcA-a BorrA!s S....Racca A. (Immunol. Invest. 2009)
    273. HLA-DRB1 and -DQB1 loci in three west African ethnic groups: genetic relationship with sub-Saharan African and European populations. (PubMed id 19664674)1, 4 Lulli P....Modiano D. (Hum. Immunol. 2009)
    274. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    275. HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis. (PubMed id 19165231)1, 4 Kominami S....Kimura A. (J. Hum. Genet. 2009)
    276. HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain). (PubMed id 19585166)1, 4 FernA!ndez O....Leyva L. (J. Neurol. 2009)
    277. [Association study between HLA-DRB genes and asthmatic children]. (PubMed id 20095337)1, 4 Zhao J....Qiu C.C. (Zhonghua Yi Xue Za Zhi 2009)
    278. Epigenetics in multiple sclerosis susceptibility: difference in transgenerational risk localizes to the major histocompatibility complex. (PubMed id 19098025)1, 4 Chao M.J....Ebers G.C. (Hum. Mol. Genet. 2009)
    279. HLA haplotypes and birth weight variation: is your future going to be light or heavy? (PubMed id 19500315)1, 4 Capittini C....Cuccia M. (Tissue Antigens 2009)
    280. Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci. (PubMed id 19116923)1, 4 Vignal C....Wilson A.G. (Arthritis Rheum. 2009)
    281. Allelic distribution and the effect of haplotype combination for HLA type II loci in the celiac disease population of the Valencian community (Spain). (PubMed id 19254257)1, 4 Donat E....Ribes-Koninckx C. (Tissue Antigens 2009)
    282. Influence of common and specific HLA-DRB1/DQB1 haplotypes on genetic susceptibilities of three distinct Arab populations to type 1 diabetes. (PubMed id 19005023)1, 4 Stayoussef M....Almawi W.Y. (Clin. Vaccine Immunol. 2009)
    283. Effects of mismatching for minor histocompatibility antigens on clinical outcomes in HLA-matched, unrelated hematopoietic stem cell transplants. (PubMed id 19539218)1, 4 Spellman S....Ellis T.M. (Biol. Blood Marrow Transplant. 2009)
    284. Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent associations with type 1 diabetes in Norwegian families. (PubMed id 18987644)1, 4 Eike M.C....Lie B.A. (Genes Immun. 2009)
    285. The gene founder effect of two spontaneous mutations in ethnic Chinese (Taiwanese) CAH patients with 21-hydroxylase deficiency. (PubMed id 19201236)1, 4 Lee Y.J....Lee H.H. (Mol. Genet. Metab. 2009)
    286. Molecular analysis of HLA-DRB1 allelic associations with systemic lupus erythematous and lupus nephritis in Taiwan. (PubMed id 19502265)1, 4 Pan C.F....Lee Y.J. (Lupus 2009)
    287. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    288. High-resolution HLA matching in double-umbilical-cord-blood reduced-intensity transplantation in adults. (PubMed id 19159415)1, 4 Delaney M....Ballen K.K. (Transfusion 2009)
    289. Study on association between polymorphism of HLA-DRB1 alleles and BehAset's disease. (PubMed id 20205319)1, 4 Shang Y.B....Chen H.D. (J Eur Acad Dermatol Venereol 2009)
    290. Human leukocyte antigen profile in HIV-1 infected individuals and AIDS patients from Chongqing, China. (PubMed id 19703245)1, 4 Huang X....Xiong H. (Microbiol. Immunol. 2009)
    291. The HLA alleles DRB1*13 and DQB1*06 are associated to Whipple's disease. (PubMed id 19208355)1, 4 Martinetti M....Corazza G.R. (Gastroenterology 2009)
    292. Combining effects of polymorphism of tumor necrosis factor alpha 5'-flanking region and HLA-DRB1 on radiological progression in patients with rheumatoid arthritis. (PubMed id 19002558)1, 4 Ichikawa N....Kamatani N. (Mod Rheumatol 2009)
    293. Prediction of duration and success rate of unrelated hematopoietic stem cell donor searches based on the patient's HLA-DRB1 allele and DRB1-DQB1 haplotype frequencies. (PubMed id 19290000)1, 4 Hirv K....Mytilineos J. (Bone Marrow Transplant. 2009)
    294. Differential association of HLA with three subtypes of type 1 diabetes: fulminant, slowly progressive and acute-onset. (PubMed id 19812988)1, 4 Kawabata Y....Makino H. (Diabetologia 2009)
    295. MHC class I and class II genes in Tunisian patients with reactive and undifferentiated arthritis. (PubMed id 19473559)1, 4 Siala M....Makni H. (Clin. Exp. Rheumatol. 2009)
    296. HLA-DR, -DQB typing of steroid-sensitive idiopathic nephrotic syndrome children in Taiwan. (PubMed id 19390203)1, 4 Huang Y.Y....Lan J.L. (Nephron Clin Pract 2009)
    297. Immunogenetic susceptibility to diabetes mellitus in patients with liver disease. (PubMed id 19663932)1, 4 Montano-Loza A.J....Mason A.L. (Liver Int. 2009)
    298. An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 gene. (PubMed id 19193207)1, 4 Ramagopalan S.V....Wittkowski K.M. (BMC Med. Genet. 2009)
    299. Genotype and phenotype correlations in diabetic patients in Uruguay. (PubMed id 19937591)1, 4 Mimbacas A....Javiel G. (Genet. Mol. Res. 2009)
    300. Multiple sclerosis risk: interaction between human leukocyte antigen and the environment in Sardinian population. (PubMed id 19625333)1, 4 Cocco E....Marrosu M.G. (Mult. Scler. 2009)
    301. Genetic susceptibility to haemorrhagic fever with renal syndrome caused by Hantaan virus in Chinese Han population. (PubMed id 19473214)1, 4 Wang M.L....Jin B.Q. (Int. J. Immunogenet. 2009)
    302. Prominent brainstem and cerebellar involvement in multiple sclerosis with psoriasis. (PubMed id 19482865)1, 4 Ganesvaran G....Pender M.P. (Mult. Scler. 2009)
    303. HLA class II (DRB, DQA1 and DQB1) allele and haplotype frequencies in the patients with pemphigus vulgaris. (PubMed id 18780165)1, 4 Shams S....Nikbin B. (J. Clin. Immunol. 2009)
    304. Association of human leukocyte antigen class II alleles with severe acute respiratory syndrome in the Vietnamese population. (PubMed id 19445991)1, 4 Keicho N....Quy T. (Hum. Immunol. 2009)
    305. Genetic polymorphism at codon 129 of the prion protein gene is not associated with multiple sclerosis. (PubMed id 19204171)1, 4 StA1ve O....Oksenberg J.R. (Arch. Neurol. 2009)
    306. A regulatory SNP at position -899 in CDKN1A is associated with systemic lupus erythematosus and lupus nephritis. (PubMed id 19262578)1, 4 Kim K....Bae S.C. (Genes Immun. 2009)
    307. HLA-DR-DQ haplotypes and type 1 diabetes in Macedonia. (PubMed id 19332095)1, 4 Ilonen J....Knip M. (Hum. Immunol. 2009)
    308. HLA risk markers for chronic myelogenous leukemia in Eastern Canada. (PubMed id 19235017)1, 4 Naugler C. and Liwski R. (amp 2009)
    309. Risk for intentional violent death associated with HLA genotypes: a preliminary survey of deceased American organ donors. (PubMed id 19495996)1, 4 Hollar D.W. (Genetica 2009)
    310. The DERAA HLA-DR alleles in patients with early polyarthritis: protection against severe disease and lack of association with rheumatoid arthritis autoantibodies. (PubMed id 19248090)1, 4 Carrier N....Boire G. (Arthritis Rheum. 2009)
    311. Non-inherited maternal human leukocyte antigen alleles in susceptibility to familial rheumatoid arthritis. (PubMed id 18684745)1, 4 Guthrie K.A....Nelson J.L. (Ann. Rheum. Dis. 2009)
    312. Analysis of maternal-offspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes. (PubMed id 19143818)1, 4 Bronson P.G....Barcellos L.F. (amp 2009)
    313. Homozygosity for DNASE2 single nucleotide polymorphisms in the 5'-regulatory region is associated with rheumatoid arthritis. (PubMed id 18812394)1, 4 Rossol M....Wagner U. (Ann. Rheum. Dis. 2009)
    314. A functional haplotype of PADI4 gene in rheumatoid arthritis: positive correlation in a French population. (PubMed id 19332633)1, 4 Gandjbakhch F....Solau-Gervais E. (J. Rheumatol. 2009)
    315. HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine. (PubMed id 19200828)1, 4 Ovsyannikova I.G....Poland G.A. (Vaccine 2009)
    316. Evidence for an association of HLA-DRB1*15 and DRB1*09 with leprosy and the impact of DRB1*09 on disease onset in a Chinese Han population. (PubMed id 20003324)1, 4 Zhang F....Liu J. (BMC Med. Genet. 2009)
    317. HLA class I and II polymorphisms in Mexican Mestizo patients with dengue fever. (PubMed id 19653987)1, 4 FalcA^n-Lezama J.A....Vargas-AlarcA^n G. (Acta Trop. 2009)
    318. Confirmation of the novel association at the BTNL2 locus with ulcerative colitis. (PubMed id 19659809)1, 4 Pathan S....Jewell D.P. (Tissue Antigens 2009)
    319. Clinical and immunogenetic prognostic factors for radiographic severity in ankylosing spondylitis. (PubMed id 19565552)1, 4 Ward M.M....Weisman M.H. (Arthritis Rheum. 2009)
    320. Autoantibodies to a 140-kd protein in juvenile dermatomyositis are associated with calcinosis. (PubMed id 19479859)1, 4 Gunawardena H....McHugh N.J. (Arthritis Rheum. 2009)
    321. HLA-A, -B, -C, and -DRB1 allele and haplotype frequencies distinguish Eastern European Americans from the general European American population. (PubMed id 19000140)1, 4 Mack S.J....Hurley C.K. (Tissue Antigens 2009)
    322. HLA-DRB1 and month of birth in multiple sclerosis. (PubMed id 20018638)1, 4 Ramagopalan S.V....Ebers G.C. (Neurology 2009)
    323. HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms. (PubMed id 19180512)1, 4 Lin Y.J....Tsai F.J. (Arthritis Rheum. 2009)
    324. Haplotype analysis of HLA-A, -B antigens and -DRB1 alleles in south Indian HIV-1-infected patients with and without pulmonary tuberculosis. (PubMed id 19392836)1, 4 Raghavan S....Narayanan P.R. (Int. J. Immunogenet. 2009)
    325. Major histocompatibility complex class II (DRB1*, DQA1*, and DQB1*) and DRB1*04 subtypes' associations of Hashimoto's thyroiditis in a Greek population. (PubMed id 19254248)1, 4 Kokaraki G....Yovos J.G. (Tissue Antigens 2009)
    326. Ethnic and geographical differences in HLA associations with the outcome of hepatitis C virus infection. (PubMed id 19409091)1, 4 Wang J.H....Rong L. (Virol. J. 2009)
    327. Impact of polymorphisms of the major histocompatibility complex class II, interleukin-10, tumor necrosis factor-alpha and cytotoxic T-lymphocyte antigen-4 genes on inhibitor development in severe hemophilia A. (PubMed id 19817985)1, 4 Pavlova A....Oldenburg J. (J. Thromb. Haemost. 2009)
    328. Human leukocyte antigens I and II haplotypes associated with human papillomavirus 16-positive invasive cervical cancer in Mexican women. (PubMed id 19820376)1, 4 HernA!ndez-HernA!ndez D.M....Mohar-Betancourt A. (Int. J. Gynecol. Cancer 2009)
    329. [A 1:2 matched case-control study on the interaction of HPV16E6 and HLA-DR9 allele to esophageal cancer in Kazakh ethnicity, Xinjiang]. (PubMed id 20193235)1, 4 Liao P.H....He L. (Zhonghua Liu Xing Bing Xue Za Zhi 2009)
    330. HLA-DR allele frequencies in Mexican mestizos with autoimmune liver diseases including overlap syndromes. (PubMed id 19811438)1, 4 Zepeda-Gomez S....Vargas-AlarcA^n G. (Immunol. Invest. 2009)
    331. Genetic variation of promoter sequence modulates XBP1 expression and genetic risk for vitiligo. (PubMed id 19543371)1, 4 Ren Y....Zhang X. (PLoS Genet. 2009)
    332. Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetes. (PubMed id 19820007)1, 4 Triolo T.M....Barker J.M. (J. Clin. Endocrinol. Metab. 2009)
    333. Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis. (PubMed id 19898480)1, 4 Mahdi H....Lundberg K. (Nat. Genet. 2009)
    334. Phenotypic variance in childhood coeliac disease and the HLA-DQ/DR dose effect. (PubMed id 18932050)1, 4 Vermeulen B.A....Mearin M.L. (Scand. J. Gastroenterol. 2009)
    335. Ethnic differences in immunogenetic features and photosensitivity of cutaneous lupus erythematosus. (PubMed id 18797890)1, 4 Furukawa F. and Muto M. (Arch. Dermatol. Res. 2009)
    336. High-resolution human leukocyte antigen (HLA) haplotypes and linkage disequilibrium of HLA-B and -C and HLA-DRB1 and -DQB1 alleles in a Taiwanese population. (PubMed id 19480851)1, 4 Yang K.L....Lin P.Y. (Hum. Immunol. 2009)
    337. Polymorphisms of HLA genes in Western Javanese (Indonesia): close affinities to Southeast Asian populations. (PubMed id 19140832)1, 4 Yuliwulandari R....Tokunaga K. (Tissue Antigens 2009)
    338. Immunogenetic risks of anti-cyclical citrullinated peptide antibodies in a North American Native population with rheumatoid arthritis and their first-degree relatives. (PubMed id 19411392)1, 4 El-Gabalawy H.S....Oen K. (J. Rheumatol. 2009)
    339. Association of HLA-A, B, DRB1 alleles and haplotypes with HIV-1 infection in Chongqing, China. (PubMed id 20003377)1, 4 Huang X....Xiong H. (BMC Infect. Dis. 2009)
    340. The tag SNP for HLA-DRB1*1501, rs3135388, is significantly associated with multiple sclerosis susceptibility: cost-effective high-throughput detection by real-time PCR. (PubMed id 19433080)1, 4 ZivkoviA8 M....AlavantiA8 D. ( international journal of clinical chemistry 2009)
    341. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. (PubMed id 19525953)1, 4 De Jager P.L....Oksenberg J.R. (Nat. Genet. 2009)
    342. HLA allele and haplotype frequencies in the Albanian population and their relationship with the other European populations. (PubMed id 19703234)1, 4 Sulcebe G....Kardhashi V. (Int. J. Immunogenet. 2009)
    343. Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis. (PubMed id 19333951)1, 4 van der Woude D....de Vries R.R. (Arthritis Rheum. 2009)
    344. Association of cytotoxic T lymphocyte antigen-4 gene polymorphisms and HLA class II alleles with the development of type 1 diabetes in Korean children and adolescents. (PubMed id 19949652)1, 4 Jung M.H....Lee B.C. (J. Korean Med. Sci. 2009)
    345. HLA-DRB1 and multiple sclerosis in Argentina. (PubMed id 19364369)1, 4 Patrucco L....Cristiano E. (Eur. J. Neurol. 2009)
    346. Effect of the human leukocyte antigen HLA-DRB1 and anti-cyclic citrullinated peptide on the outcome of rheumatoid arthritis patients. (PubMed id 19738989)1, 4 Farouk H.M....Zarouk W.A. (Braz. J. Med. Biol. Res. 2009)
    347. HLA class II polymorphism in patients with type 1 diabetes mellitus from a Brazilian racially admixtured population. (PubMed id 20073143)1, 4 Alves C....Carvalho G.C. (amp 2009)
    348. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. (PubMed id 19571811)1, 4  ....Sklar P. (Nature 2009)
    349. HLA polymorphism in six Malay subethnic groups in Malaysia. (PubMed id 19364514)1, 4 Edinur H.A....Norazmi M.N. (Hum. Immunol. 2009)
    350. Influence of nitric oxide synthase gene polymorphisms on the risk of cardiovascular events in rheumatoid arthritis. (PubMed id 19327239)1, 4 Gonzalez-Gay M.A....Martin J. (Clin. Exp. Rheumatol. 2009)
    351. The common Scandinavian human leucocyte antigen ancestral haplotype 62.1 as prognostic factor in patients with advanced malignant melanoma. (PubMed id 19214504)1, 4 Helgadottir H....Masucci G.V. (Cancer Immunol. Immunother. 2009)
    352. Protective role of the HLA-A*02 allele in Portuguese patients with multiple sclerosis. (PubMed id 19482867)1, 4 Silva A.M....Martins B. (Mult. Scler. 2009)
    353. Identification of HLA-A*02-B*46 haplotype allele variant in Guangdong Han populations on the basis of PCR-SBT. (PubMed id 19348686)1, 4 Xiong F....Huang F. (BMC Res Notes 2009)
    354. The role of polymorphic protein tyrosine phosphatase non-receptor type 22 in leprosy. (PubMed id 19516267)1, 4 Rani R....Kar H.K. (J. Invest. Dermatol. 2009)
    355. HLA genes in Uros from Titikaka Lake, Peru: origin and relationship with other Amerindians and worldwide populations. (PubMed id 19490211)1, 4 Arnaiz-Villena A....Moscoso J. (Int. J. Immunogenet. 2009)
    356. HLA antigens and nontuberculous mycobacterial lung disease in Korean patients. (PubMed id 19219503)1, 4 Um S.W....Koh W.J. (Lung 2009)
    357. Association of HLA alleles with hepatitis C infection in Maharashtra, western India. (PubMed id 20090103)1, 4 Tripathy A.S....Arankalle V.A. (Indian J. Med. Res. 2009)
    358. Positive association of DRB1 04 and DRB1 15 alleles with Fya immunization in a Southern European population. (PubMed id 19702653)1, 4 Picard C....Chiaroni J. (Transfusion 2009)
    359. Sporadic inclusion body myositis: HLA-DRB1 allele interactions influence disease risk and clinical phenotype. (PubMed id 19720533)1, 4 Mastaglia F.L....Christiansen F.T. (Neuromuscul. Disord. 2009)
    360. Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis. (PubMed id 19287509)1, 4 Cui J....Karlson E.W. (Mol. Med. 2009)
    361. Is neuromyelitis optica associated with human leukocyte antigen? (PubMed id 19299434)1, 4 ZAcphir H....de Seze J. (Mult. Scler. 2009)
    362. Anti-&quot;Mi(a)&quot; immunization is associated with HLA-DRB1*0901. (PubMed id 19243543)1, 4 Chu C.C....Lin M. (Transfusion 2009)
    363. Identification of MICA as a susceptibility gene for pulmonary Mycobacterium avium complex infection. (PubMed id 19405864)1, 4 Shojima J....Inoko H. (J. Infect. Dis. 2009)
    364. The frequency of HLA class I and II alleles in Pakistani patients with aplastic anemia. (PubMed id 19860590)1, 4 Rehman S....Mehmood T. (Immunol. Invest. 2009)
    365. TNF-alpha polymorphisms in primary biliary cirrhosis: a northern and southern Italian experience. (PubMed id 19758199)1, 4 Niro G.A....Invernizzi P. (Ann. N. Y. Acad. Sci. 2009)
    366. TRAF1/C5 polymorphism is not associated with pemphigus. (PubMed id 19416238)1, 4 Mejri K....Makni S. (Br. J. Dermatol. 2009)
    367. Diabetes-specific HLA-DR-restricted proinflammatory T-cell response to wheat polypeptides in tissue transglutaminase antibody-negative patients with type 1 diabetes. (PubMed id 19401421)1, 4 Mojibian M....Scott F.W. (Diabetes 2009)
    368. Synergistic effect of HLA class II loci and cytokine gene polymorphisms on the risk of gastric cancer in Japanese patients with Helicobacter pylori infection. (PubMed id 19544559)1, 4 Ando T....Yoshikawa T. (Int. J. Cancer 2009)
    369. Association of HY-restricting HLA class II alleles with pregnancy outcome in patients with recurrent miscarriage subsequent to a firstborn boy. (PubMed id 19223392)1, 4 Nielsen H.S....Christiansen O.B. (Hum. Mol. Genet. 2009)
    370. HLA-B is the best candidate of susceptibility genes in HLA for Japanese ulcerative colitis. (PubMed id 19493234)1, 4 Aizawa H....Shimosegawa T. (Tissue Antigens 2009)
    371. Genomewide association study of leprosy. (PubMed id 20018961)1, 4 Zhang F.R....Liu J.J. (N. Engl. J. Med. 2009)
    372. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. (PubMed id 19879194)1, 4 De Jager P.L....Karlson E.W. (Lancet Neurol 2009)
    373. HLA-DRB1 among patients with Vogt-Koyanagi-Harada disease in Saudi Arabia. (PubMed id 19756183)1, 4 Iqniebi A....Tabbara K.F. (Mol. Vis. 2009)
    374. HLA DRB1*130101-DQB1*060101 haplotype is associated with acute chest syndrome in sickle cell anemia patients. (PubMed id 19254255)1, 4 Mahdi N....Almawi W.Y. (Tissue Antigens 2009)
    375. MHC Class II alleles in ulcerative colitis-associated colorectal cancer. (PubMed id 19251712)1, 4 Garrity-Park M.M....Smyrk T.C. (Gut 2009)
    376. Molecular study of receptor for advanced glycation endproduct gene promoter and identification of specific HLA haplotypes possibly involved in chronic fatigue syndrome. (PubMed id 19822091)1, 4 Carlo-Stella N....Cuccia M. (Int J Immunopathol Pharmacol 2009)
    377. Tunisian endemic pemphigus foliaceus is associated with the HLA-DR3 gene: anti-desmoglein 1 antibody-positive healthy subjects bear protective alleles. (PubMed id 19486004)1, 4 Abida O....Masmoudi H. (Br. J. Dermatol. 2009)
    378. Association of the human leukocyte antigen class II alleles with chronic atrophic gastritis and gastric carcinoma in Koreans. (PubMed id 19906105)1, 4 Lee H.W....Lee K.W. (J Dig Dis 2009)
    379. Clinical and human leucocyte antigen class II haplotype associations of autoantibodies to small ubiquitin-like modifier enzyme, a dermatomyositis-specific autoantigen target, in UK Caucasian adult-onset myositis. (PubMed id 18930994)1, 4 Betteridge Z.E....McHugh N.J. (Ann. Rheum. Dis. 2009)
    380. Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci. (PubMed id 19741008)1, 4 McClure A....Barton A. (Rheumatology (Oxford) 2009)
    381. Association of HLA-DR and -DQ Genes with Familial Moyamoya Disease in Koreans. (PubMed id 20062572)1, 4 Hong S.H....Park M.H. (J Korean Neurosurg Soc 2009)
    382. A single nucleotide polymorphism in the IRF5 promoter region is associated with susceptibility to rheumatoid arthritis in the Japanese population. (PubMed id 18408250)1, 4 Shimane K....Yamamoto K. (Ann. Rheum. Dis. 2009)
    383. Acute disseminated encephalomyelitis: clinical features, HLA DRB1*1501, HLA DRB1*1503, HLA DQA1*0102, HLA DQB1*0602, and HLA DPA1*0301 allelic association study. (PubMed id 19722042)1, 4 Alves-Leon S.V....Quirico-Santos T. (Arq Neuropsiquiatr 2009)
    384. Analysis of HLA DR2&amp;DQ6 (DRB1*1501, DQA1*0102, DQB1*0602) haplotypes in Iranian patients with multiple sclerosis. (PubMed id 18726686)1, 4 Ghabaee M....Hashemi Chelavi L. (Cell. Mol. Neurobiol. 2009)
    385. HLA type and immune response to Borrelia burgdorferi outer surface protein a in people in whom arthritis developed after Lyme disease vaccination. (PubMed id 19333928)1, 4 Ball R....Braun M.M. (Arthritis Rheum. 2009)
    386. Genetic factors in mother-to-child transmission of HCV infection. (PubMed id 19481774)1, 4 Bevilacqua E....Amoroso A. (Virology 2009)
    387. Molecular variation at the HLA-A, B, C, DRB1, DQA1, and DQB1 loci in full heritage American Indians in Arizona: private haplotypes and their evolution. (PubMed id 19845915)1, 4 Williams R....Knowler W. (Tissue Antigens 2009)
    388. HLA-A disparities illustrate challenges for ranking the impact of HLA mismatches on bone marrow transplant outcomes in the United States. (PubMed id 19589487)1, 4 Baxter-Lowe L.A....Hurley C.K. (Biol. Blood Marrow Transplant. 2009)
    389. The frequent and conserved DR3-B8-A1 extended haplotype confers less diabetes risk than other DR3 haplotypes. (PubMed id 19143812)1, 4 Baschal E.E....Eisenbarth G.S. (amp 2009)
    390. Human leukocyte antigens among primary biliary cirrhosis patients born in Mexico. (PubMed id 19221531)1, 4 VA!zquez-Elizondo G....MAcndez-SA!nchez N. (Ann Hepatol 2009)
    391. Clear and independent associations of several HLA-DRB1 alleles with differential antibody responses to hepatitis B vaccination in youth. (PubMed id 19597844)1, 4 Li Y....Tang J. (Hum. Genet. 2009)
    392. Full likelihood analysis of genetic risk with variable age at onset disease--combining population-based registry data and demographic information. (PubMed id 19718441)1, 4 PitkAoniemi J....Arjas E. (PLoS ONE 2009)
    393. [Analysis on haplotypes of five HLA loci in southern Chinese Han population by sequence-based typing]. (PubMed id 19350523)1, 4 Gao S.Q....Deng Z.H. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2009)
    394. HLA-association of serum levels of natural antibodies. (PubMed id 19167759)1, 4 Pozsonyi E....FA1st G. (Mol. Immunol. 2009)
    395. Replication of rubella vaccine population genetic studies: validation of HLA genotype and humoral response associations. (PubMed id 19761839)1, 4 Ovsyannikova I.G....Poland G.A. (Vaccine 2009)
    396. High-resolution HLA genotyping and severe cutaneous adverse reactions in lamotrigine-treated patients. (PubMed id 19668019)1, 4 Kazeem G.R....Foot E. (Pharmacogenet. Genomics 2009)
    397. HLA haplotype A33-B58-Cw10 may modulate radiographic development of bamboo spine in Taiwanese patients with primary ankylosing spondylitis. (PubMed id 19407364)1, 4 Lu M.C....Lai N.S. (Dis. Markers 2009)
    398. IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients. (PubMed id 19156166)1, 4 Couturier N....Brassat D. (Eur. J. Hum. Genet. 2009)
    399. High resolution human leukocyte antigen (HLA) class I and class II allele typing in Mexican mestizo women with sporadic breast cancer: case-control study. (PubMed id 19196481)1, 4 CantA_ de LeA^n D....Granados J. (BMC Cancer 2009)
    400. Additional sequence analysis outside exon 2 clarifies DRB1*12 and DRB1*14 allelic frequencies in Koreans. (PubMed id 19286445)1, 4 Lee K.W. and Jung Y.A. (Hum. Immunol. 2009)
    401. Analysis of HLA class I and II alleles regarding to lymph node and distant metastasis in patients with non-small cell lung cancer. (PubMed id 19246116)1, 4 Bulut I....Gorguner M. (Lung Cancer 2009)
    402. Parent-of-origin of HLA-DRB1*1501 and age of onset of multiple sclerosis. (PubMed id 19629136)1, 4 Ramagopalan S.V....Sadovnick A.D. (J. Hum. Genet. 2009)
    403. Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles. (PubMed id 18635594)1, 4 Snir O....MalmstrAPm V. (Ann. Rheum. Dis. 2009)
    404. [Relation of HLA-DRB1*15 with pathogenesis in 162 childhood cases of acute lymphoblastic leukemia]. (PubMed id 20030936)1, 4 Wang X.J....Zhu X.F. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009)
    405. Association of HLA class II genes with systemic sclerosis in Spanish patients. (PubMed id 19884273)1, 4 SimeA^n C.P....Vilardell M. (J. Rheumatol. 2009)
    406. HLA-DR and HLA-DQ alleles in patients from the south of Brazil: markers for leprosy susceptibility and resistance. (PubMed id 19698125)1, 4 da Silva S.A....Visentainer J.E. (BMC Infect. Dis. 2009)
    407. Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLA. (PubMed id 19204159)1, 4 Cree B.A....Oksenberg J.R. (Arch. Neurol. 2009)
    408. Variation in the ATP-binding cassette transporter 2 gene is a separate risk factor for systemic lupus erythematosus within the MHC. (PubMed id 19387463)1, 4 Ramos P.S....Moser K.L. (Genes Immun. 2009)
    409. The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype is a risk factor for toluene diisocyanate-induced occupational asthma. (PubMed id 19439981)1, 4 Choi J.H....Park H.S. (Int. Arch. Allergy Immunol. 2009)
    410. Long-range linkage on chromosome 6p of VEGF, FKBP5, HLA and TNF alleles associated with transplant rejection. (PubMed id 19233472)1, 4 Chen Y....Hutchinson I.V. (Mol. Immunol. 2009)
    411. Association between protective and deleterious HLA alleles with multiple sclerosis in Central East Sardinia. (PubMed id 19654877)1, 4 Pastorino R....Bernardinelli L. (PLoS ONE 2009)
    412. The effect of the MHC locus on autoantibodies in type 1 diabetes. (PubMed id 19429597)1, 4 Qu H.Q. and Polychronakos C. (J. Med. Genet. 2009)
    413. The association of anti-r-HuEpo-associated pure red cell aplasia with HLA-DRB1*09-DQB1*0309. (PubMed id 18689790)1, 4 Praditpornsilpa K....Eiam-Ong S. (Nephrol. Dial. Transplant. 2009)
    414. HLA class I and class II polymorphisms in Saudi patients with myasthenia gravis. (PubMed id 19490212)1, 4 Hajeer A.H....Al Jumah M. (Int. J. Immunogenet. 2009)
    415. HLA-DQ, DR allele polymorphism of type 1 diabetes in the Chinese population: a meta-analysis. (PubMed id 19493426)1, 4 Zhang X.M....Ji L.N. (Chin. Med. J. 2009)
    416. Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. (PubMed id 19143814)1, 4 Valdes A.M. and Thomson G. (amp 2009)
    417. Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. (PubMed id 19525955)1, 4 (Nat. Genet. 2009)
    418. HLA-B62 and HLA-DQ8 are associated with Complex Regional Pain Syndrome with fixed dystonia. (PubMed id 19523767)1, 4 de Rooij A.M....van Hilten J.J. (Pain 2009)
    419. HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients. (PubMed id 19104471)1, 4 Chantarangsu S....Nakamura Y. (Pharmacogenet. Genomics 2009)
    420. Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures. (PubMed id 19022862)1, 4 Okuda D.T....Pelletier D. (Brain 2009)
    421. Donor-recipient mismatches in MHC class I chain-related gene A in unrelated donor transplantation lead to increased incidence of acute graft-versus-host disease. (PubMed id 19654407)1, 4 Parmar S....Fernandez-Vina M. (Blood 2009)
    422. Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes? (PubMed id 19188433)1, 4 Steck A.K....Rewers M.J. (Diabetes 2009)
    423. Polymorphism located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype confer susceptibility to CNS hypersomnias (essential hypersomnia). (PubMed id 19404393)1, 4 Miyagawa T....Tokunaga K. (PLoS ONE 2009)
    424. Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility. (PubMed id 19380721)1, 4 Lincoln M.R....Ebers G.C. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    425. A systematic meta-analysis of genetic association studies for diabetic retinopathy. (PubMed id 19587357)1, 4 Abhary S....Craig J.E. (Diabetes 2009)
    426. [Genetic predisposition to multiple sclerosis as a polygenic autoimmune disease]. (PubMed id 19894308)1, 4 Favorova O.O....Ochs M.F. (Zh Nevrol Psikhiatr Im S S Korsakova 2009)
    427. Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis. (PubMed id 19683555)1, 4 Fialho R.N....Bruges-Armas J. (Hum. Immunol. 2009)
    428. [Study on the association between chronic hepatitis B cirrhosis and HLA-DRB1 * 1301,1302 allele]. (PubMed id 20108780)1, 4 Liang H.X....Jiang H.Q. (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2009)
    429. The non-inherited maternal HLA haplotype affects the risk for type 1 diabetes. (PubMed id 19055605)1, 4 Akesson K....Kockum I. (Int. J. Immunogenet. 2009)
    430. HLA-DPB1 associations differ between DRB1*03 positive anti-Jo-1 and anti-PM-Scl antibody positive idiopathic inflammatory myopathy. (PubMed id 19690132)1, 4 Chinoy H....Cooper R.G. (Rheumatology (Oxford) 2009)
    431. [DRB1 * 1454: the common allele of human leukocyte antigen-DRB1 * 14 in Chinese Han populations]. (PubMed id 20017299)1, 4 Cheng L.H....Wang D.M. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2009)
    432. Effect of polymorphism in insulin locus and HLA on type 1 diabetes in four ethnic groups in Israel. (PubMed id 19000139)1, 4 Benedek G....Israel S. (Tissue Antigens 2009)
    433. Three microsatellites from the T1DGC MHC data set show highly significant association with type 1 diabetes, independent of the HLA-DRB1, -DQA1 and -DQB1 genes. (PubMed id 19143811)1, 4 Eike M.C....Lie B.A. (amp 2009)
    434. HLA-A *3303* and *3301 predispose patients to persistent hepatitis B infection. (PubMed id 19337647)1, 4 Ramezani A....Velayati A.A. (J Gastrointestin Liver Dis 2009)
    435. Influence of HLA-DRB1 alleles on antibody responses to PfCP-2.9-immunized and naturally infected individuals. (PubMed id 19247821)1, 4 Zhang Q....Pan W. (J. Clin. Immunol. 2009)
    436. Primary autoimmune neutropenia in children in Taiwan. (PubMed id 19210322)1, 4 Wang L.Y....Lin M. (Transfusion 2009)
    437. Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis. (PubMed id 19630074)1, 4 Lorentzen A.R....Harbo H.F. (Ann. Neurol. 2009)
    438. Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis: all alleles are important. (PubMed id 19479873)1, 4 LundstrAPm E....Padyukov L. (Arthritis Rheum. 2009)
    439. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. (PubMed id 19122664)1, 4 Silverberg M.S....Duerr R.H. (Nat. Genet. 2009)
    440. Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach. (PubMed id 19143821)1, 4 McKinnon E....James I. (amp 2009)
    441. Autoimmune type 1 diabetes genetic susceptibility encoded by human leukocyte antigen DRB1 and DQB1 genes in Tunisia. (PubMed id 19553558)1, 4 Stayoussef M....Almawi W.Y. (Clin. Vaccine Immunol. 2009)
    442. Haplotype-based search for SNPs associated with differential type 1 diabetes risk among chromosomes carrying a specific HLA DRB1-DQA1-DQB1 haplotype. (PubMed id 19143810)1, 4 McGinnis R....Deloukas P. (amp 2009)
    443. The value of HLA-DRB1 shared epitope, -308 tumor necrosis factor-alpha gene promoter polymorphism, rheumatoid factor, anti-citrullinated peptide antibodies, and early erosions for predicting radiological outcome in recent-onset rheumatoid arthritis. (PubMed id 19411391)1, 4 Reneses S....GarcA-a A. (J. Rheumatol. 2009)
    444. HLA-DRB1 associations with disease susceptibility and clinical course in Australians with multiple sclerosis. (PubMed id 19392788)1, 4 Stankovich J....Rubio J.P. (Tissue Antigens 2009)
    445. Clinical, immunological, and genetic features of autoimmune primary adrenal insufficiency: observations from a Norwegian registry. (PubMed id 19858318)1, 4 Erichsen M.M....Husebye E.S. (J. Clin. Endocrinol. Metab. 2009)
    446. Association of the HLA-DPB1*0501 allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders. (PubMed id 19140826)1, 4 Matsushita T....Kira J. (Tissue Antigens 2009)
    447. Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. (PubMed id 19956635)1, 4 Holmes M.V....Casas J.P. (PLoS ONE 2009)
    448. Association of susceptibility to multiple sclerosis in Southern Han Chinese with HLA-DRB1, -DPB1 alleles and DRB1-DPB1 haplotypes: distinct from other populations. (PubMed id 19965521)1, 4 Wu X.M....Gong L.Y. (Mult. Scler. 2009)
    449. Maternal BMI before pregnancy, maternal weight gain during pregnancy, and risk of persistent positivity for multiple diabetes-associated autoantibodies in children with the high-risk HLA genotype: the MIDIA study. (PubMed id 19592628)1, 4 Rasmussen T....nningen K.S. (Diabetes Care 2009)
    450. HLA class I and II alleles and response to treatment with interferon-beta in relapsing-remitting multiple sclerosis. (PubMed id 19349081)1, 4 Comabella M....Montalban X. (J. Neuroimmunol. 2009)
    451. [Association of the PADI4 gene polymorphism and HLA-DRB1 shared epitope alleles with rheumatoid arthritis]. (PubMed id 19199253)1, 4 Fan L.Y....Ma J.W. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2009)
    452. Human leukocyte antigen frequency in human high-grade gliomas: a case-control study in Sicily. (PubMed id 19487887)1, 4 La Torre D....Tomasello F. (Neurosurgery 2009)
    453. Distribution of HLA-A, -B, -Cw, and -DRB1 alleles and haplotypes in an isolated Han population in Southwest China. (PubMed id 19493233)1, 4 Yao Y....Chu J. (Tissue Antigens 2009)
    454. Interaction of vitamin D receptor with HLA DRB1 0301 in type 1 diabetes patients from North India. (PubMed id 19956544)1, 4 Israni N....Rani R. (PLoS ONE 2009)
    455. HLA-B8, DR3: a new risk factor for graft failure after renal transplantation in patients with underlying immunoglobulin A nephropathy. (PubMed id 19674013)1, 4 Andresdottir M.B....Claas F.H. (Clin Transplant 2009)
    456. HLA class II association with autoimmune hepatitis in Latin America: a meta-analysis. (PubMed id 19041429)1, 4 Duarte-Rey C....Rojas-Villarraga A. (Autoimmun Rev 2009)
    457. Human leukocyte antigen-DRB1*1101 correlates with less severe hepatitis in Taiwanese male carriers of hepatitis B virus. (PubMed id 19235869)1, 4 Huang Y.W....Kao J.H. (J. Med. Virol. 2009)
    458. [Analysis of HLA haplotype frequency and linkage disequilibrium in patients with acute lymphoblastic leukemia from Northern Chinese Han]. (PubMed id 19199259)1, 4 Gao S.Q....Deng Z.H. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2009)
    459. Association between human leukocyte antigen class II alleles and human papillomavirus-mediated cervical cancer in Indian women. (PubMed id 19272325)1, 4 Kohaar I....Bharadwaj M. (Hum. Immunol. 2009)
    460. HLA-DR4 as a risk allele for autism acting in mothers of probands possibly during pregnancy. (PubMed id 19487610)1, 4 Johnson W.G....Lambert G.H. (amp 2009)
    461. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (PubMed id 19838193)1, 4 Han J.W....Zhang X.J. (Nat. Genet. 2009)
    462. Does the DRB1*1501 allele confer more severe and faster progression in primary progressive multiple sclerosis patients? HLA in primary progressive multiple sclerosis. (PubMed id 19616314)1, 4 Vasconcelos C.C....Alvarenga R.M. (J. Neuroimmunol. 2009)
    463. The role of HLA-DRB1 alleles on susceptibility of Chinese patients with anti-GBM disease. (PubMed id 19654074)1, 4 Yang R....Zhao M.H. (Clin. Immunol. 2009)
    464. Multiple sclerosis associates with LILRA3 deletion in Spanish patients. (PubMed id 19421224)1, 4 OrdA^A+ez D....Vilches C. (Genes Immun. 2009)
    465. The proinflammatory cytokine TNF-alpha -308 AA genotype is associated with polyglandular autoimmunity. (PubMed id 19811436)1, 4 Dittmar M....Kahaly G.J. (Immunol. Invest. 2009)
    466. HLA-DR in Brazilian patients with polyarteritis nodosa (PAN) and microscopic polyangiitis (MPA). (PubMed id 19597292)1, 4 de Lira Freire A....Fernandes S.R. (Dis. Markers 2009)
    467. Selected class I and class II HLA alleles and haplotypes and risk of high-grade cervical intraepithelial neoplasia. (PubMed id 18351579)1, 4 Ades S....Franco E.L. (Int. J. Cancer 2008)
    468. Inhibitor-Immunology-Study. Different HLA-types seem to be involved in the inhibitor development in haemophilia A. (PubMed id 18958335)1, 4 Wieland I....Sykora K.W. (Hamostaseologie 2008)
    469. Human leukocyte antigens (HLA) associated with selective IgA deficiency in Iran and Sweden. (PubMed id 19052350)1, 4 Mohammadi J....Hammarstrom L. (Iran J Allergy Asthma Immunol 2008)
    470. Paroxysmal nocturnal hemoglobinuria: significant association with specific HLA-A, -B, -C, and -DR alleles in an Italian population. (PubMed id 18396213)1, 4 Lombardi M.L....Ruggiero G. (Hum. Immunol. 2008)
    471. Association of HLA alleles with non-Hodgkin's lymphoma in Korean population. (PubMed id 18301962)1, 4 Choi H.B....Kim T.G. (Int. J. Hematol. 2008)
    472. HLA class I and II and TNF-alpha gene polymorphisms in sarcoidosis patients. (PubMed id 19023492)1, 4 Morais A....Tafulo S. (Rev Port Pneumol 2008)
    473. Role of minor histocompatibility antigens in renal transplantation. (PubMed id 18093280)1, 4 Heinold A....Tran T.H. (Am. J. Transplant. 2008)
    474. CTLA-4 +49 A/G genotype and HLA-DRB1 polymorphisms in Turkish patients with Henoch-SchAPnlein purpura. (PubMed id 18449568)1, 4 Soylemezoglu O....Hasanoglu E. (Pediatr. Nephrol. 2008)
    475. [Haplotipic associations of the two most common HLA-B*27 alleles in the Croatian population]. (PubMed id 19024262)1, 4 GrubiA8 Z....Kerhin-BrkljaciA8 V. (Reumatizam 2008)
    476. Polymorphism of the oestrogen receptor beta gene (ESR2) is associated with susceptibility to Graves' disease. (PubMed id 17941906)1, 4 Kisiel B....PA8oski R. (Clin. Endocrinol. (Oxf) 2008)
    477. The role of major histocompatibility complex alleles in the susceptibility of Brazilian patients to develop the myogenic type of Graves' orbitopathy. (PubMed id 18352820)1, 4 Akaishi P.M....Donadi E.A. (Thyroid 2008)
    478. [Study of the HLA-A, B, DRB1 allele and haplotype frequencies of 4194 cord blood samples in Guangzhou]. (PubMed id 18683155)1, 4 Sha W.Q....Xie X.M. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2008)
    479. Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. (PubMed id 18449200)1, 4 Zeitlin A.A....Simmonds M.J. (Genes Immun. 2008)
    480. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. (PubMed id 18794853)1, 4 Raychaudhuri S....Plenge R.M. (Nat. Genet. 2008)
    481. CTLA-4 and multiple sclerosis: the A49G single nucleotide polymorphism shows no association with multiple sclerosis in a Southern Australian population. (PubMed id 18378005)1, 4 Wray B.N....McMorran B.J. (J. Neuroimmunol. 2008)
    482. Genetic influence of the nonclassical major histocompatibility complex class I molecule MICB in multiple sclerosis susceptibility. (PubMed id 18588574)1, 4 Fernandez-Morera J.L....Lopez-Larrea C. (Tissue Antigens 2008)
    483. Human leukocyte antigen and cytokine receptor gene polymorphisms associated with heterogeneous immune responses to mumps viral vaccine. (PubMed id 18450852)1, 4 Ovsyannikova I.G....Poland G.A. (Pediatrics 2008)
    484. HLA types in Turkish children with celiac disease. (PubMed id 19227412)1, 4 KuloA9lu Z....Girgin N. (Turk. J. Pediatr. 2008)
    485. Modifying effect of HLA haplotypes located trans to DQB1*02-DRB1*03 in celiac patients of Southern Europe. (PubMed id 18257894)1, 4 HernA!ndez-Charro B....Ramos-Arroyo M.A. (Tissue Antigens 2008)
    486. Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort study. (PubMed id 17666451)1, 4 Karlson E.W....Shadick N.A. (Ann. Rheum. Dis. 2008)
    487. Susceptibility to type 1 autoimmune hepatitis is associated with shared amino acid sequences at positions 70-74 of the HLA-DRB1 molecule. (PubMed id 18022727)1, 4 Lim Y.S....Suh D.J. (J. Hepatol. 2008)
    488. Epistasis between the MHC and the RCA alpha block in primary SjAPgren syndrome. (PubMed id 17878210)1, 4 Lester S....Dawkins R.L. (Ann. Rheum. Dis. 2008)
    489. HLA-DR2 and white matter lesion distribution in MS. (PubMed id 18482373)1, 4 Sepulcre J....Villoslada P. (J Neuroimaging 2008)
    490. Investigation on the possible relationship existing between the HLA-DR gene and attention deficit hyperactivity disorder and/or mental retardation. (PubMed id 19144284)1, 4 Aureli A....Di Loreto S. (Int J Immunopathol Pharmacol 2008)
    491. Outcome of haematopoietic stem cell transplantation in patients transplanted with matched unrelated donors vs allele-mismatched donors: a single centre study. (PubMed id 19000143)1, 4 Hauzenberger D....Remberger M. (Tissue Antigens 2008)
    492. HLA Class II alleles and the presence of circulating Epstein-Barr virus DNA in Greek patients with nasopharyngeal carcinoma. (PubMed id 18535809)1, 4 Karanikiotis C....Fountzilas G. (Strahlenther Onkol 2008)
    493. HLA-class II alleles in Egyptian patients with hepatocellular carcinoma. (PubMed id 18821214)1, 4 El-Chennawi F.A....Tawhid Z.E. (Immunol. Invest. 2008)
    494. HLA class I and II gene polymorphisms in Stevens-Johnson syndrome with ocular complications in Japanese. (PubMed id 18385790)1, 4 Ueta M....Kinoshita S. (Mol. Vis. 2008)
    495. Comprehensive analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci and squamous cell cervical cancer risk. (PubMed id 18451182)1, 4 Madeleine M.M....Galloway D.A. (Cancer Res. 2008)
    496. FCRL3 -169CT functional polymorphism in type 1 diabetes and autoimmunity traits. (PubMed id 17961971)1, 4 Duchatelet S....Julier C. (amp 2008)
    497. HLA polymorphisms as incidence factor in the progression to end-stage renal disease in Brazilian patients awaiting kidney transplant. (PubMed id 18589099)1, 4 Crispim J.C....Donadi E.A. (Transplant. Proc. 2008)
    498. Lack of association between HLA-A, -B and -DRB1 alleles and the development of SARS: a cohort of 95 SARS-recovered individuals in a population of Guangdong, southern China. (PubMed id 18186801)1, 4 Xiong P....Wang W. (Int. J. Immunogenet. 2008)
    499. Human leukocyte antigen class II allele association to disease progression in Iranian patients with chronic lymphocytic leukemia. (PubMed id 18722491)1, 4 Hojjat-Farsangi M....Shokri F. (Hum. Immunol. 2008)
    500. Matched unrelated or matched sibling donors result in comparable survival after allogeneic stem-cell transplantation in elderly patients with acute myeloid leukemia: a report from the cooperative German Transplant Study Group. (PubMed id 18768435)1, 4 Schetelig J....Ehninger G. (J. Clin. Oncol. 2008)
    501. HLA-DRB1 alleles and Henoch-SchAPnlein purpura: susceptibility and severity of disease. (PubMed id 18412308)1, 4 Soylemezoglu O....Buyan N. (J. Rheumatol. 2008)
    502. Association of specific IgE to staphylococcal superantigens with the phenotype of chronic urticaria. (PubMed id 18955792)1, 4 Ye Y.M....Park H.S. (J. Korean Med. Sci. 2008)
    503. Human leukocyte antigen class II alleles and dental caries in a child population. (PubMed id 18481581)1, 4 Altun C....Akbulut E. (Pediatr Dent 2008)
    504. Positive association of HLA-DRB1*15 with keloid disease in Caucasians. (PubMed id 18976433)1, 4 Brown J.J....Bayat A. (Int. J. Immunogenet. 2008)
    505. HLA-DRB1*04 allele is associated with severe malaria in northern Ghana. (PubMed id 18256425)1, 4 Osafo-Addo A.D....Rogers W.O. (Am. J. Trop. Med. Hyg. 2008)
    506. Polymorphisms of human leukocyte antigen genes in korean children with Kawasaki disease. (PubMed id 18064508)1, 4 Oh J.H....Choi H.B. (Pediatr Cardiol 2008)
    507. Dermatomyositis and polymyositis associated with malignancy: a 21-year retrospective study. (PubMed id 18203322)1, 4 AndrA!s C....DankA^ K. (J. Rheumatol. 2008)
    508. HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility. (PubMed id 18765817)1, 4 Chao M.J....Ebers G.C. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    509. The HLA-DRB1 shared epitope is not associated with antibodies against cyclic citrullinated peptide in Chinese patients with rheumatoid arthritis. (PubMed id 18465452)1, 4 Xue Y....Zou H.J. (Scand. J. Rheumatol. 2008)
    510. Impact of HLA-DPB1 allelic and single amino acid mismatches on HSCT. (PubMed id 18544086)1, 4 Ludajic K....Greinix H.T. (Br. J. Haematol. 2008)
    511. HLA-DRB1*0404 is strongly associated with high titers of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis. (PubMed id 18799094)1, 4 Charpin C....Auger I. (Clin. Exp. Rheumatol. 2008)
    512. The clinical implications of HLA mismatches in unrelated donor haematopoietic cell transplantation. (PubMed id 18976440)1, 4 Shaw B.E. (Int. J. Immunogenet. 2008)
    513. Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians. (PubMed id 19046302)1, 4 Shastry A....Sanjeevi C.B. (Int. J. Immunogenet. 2008)
    514. Risk conferred by HLA-DR and DQ for type 1 diabetes in 0-35-year age group in Sweden. (PubMed id 19120278)1, 4 Sanjeevi C.B....Lernmark A. (Ann. N. Y. Acad. Sci. 2008)
    515. Studies on the compatibility of HLA-Class II alleles in patient couples with severe pre-eclampsia using PCR-RFLP methods. (PubMed id 18593440)1, 4 Ooki I....Tanaka K. (Am. J. Reprod. Immunol. 2008)
    516. Association of HLA class II alleles with childhood asthma and Total IgE levels. (PubMed id 19052351)1, 4 Movahedi M....Amirzargar A. (Iran J Allergy Asthma Immunol 2008)
    517. HLA-DRB1, DQA1 and DQB1 alleles and haplotypes frequencies in Iranian healthy adult responders and non-responders to recombinant hepatitis B vaccine. (PubMed id 18523354)1, 4 Amirzargar A.A....Shokri F. (Iran J Immunol 2008)
    518. New classification of HLA-DRB1 alleles in rheumatoid arthritis susceptibility: a combined analysis of worldwide samples. (PubMed id 18307784)1, 4 Barnetche T....Gourraud P.A. (amp 2008)
    519. A sequence variation in the MOG gene is involved in multiple sclerosis susceptibility in Italy. (PubMed id 17928868)1, 4 D'Alfonso S....Momigliano-Richiardi P. (Genes Immun. 2008)
    520. HLA-DRB1*15 allele influences the later course of relapsing remitting multiple sclerosis. (PubMed id 18615093)1, 4 Cournu-Rebeix I....Fontaine B. (Genes Immun. 2008)
    521. The shared epitope hypothesis in rheumatoid arthritis: evaluation of alternative classification criteria in a large UK Caucasian cohort. (PubMed id 18438843)1, 4 Morgan A.W....Emery P. (Arthritis Rheum. 2008)
    522. Polymorphisms in genes encoding tumor necrosis factor-alpha and HLA-DRB1 are not associated with response to infliximab in patients with rheumatoid arthritis. (PubMed id 18176993)1, 4 Pinto J.A....Blanco F.J. (J. Rheumatol. 2008)
    523. Joint effects of HLA, INS, PTPN22 and CTLA4 genes on the risk of type 1 diabetes. (PubMed id 18292987)1, 4 BjA...Stene L.C. (Diabetologia 2008)
    524. A common haplotype of the C-C chemokine receptor 2 gene and HLA-DRB1*0301 are independent genetic risk factors for LAPfgren's syndrome. (PubMed id 18513341)1, 4 Spagnolo P....du Bois R.M. (J. Intern. Med. 2008)
    525. HLA-DRB1*0401 and HLA-DRB1*0408 are strongly associated with the development of antibodies against interferon-beta therapy in multiple sclerosis. (PubMed id 18656179)1, 4 Hoffmann S....Hemmer B. (Am. J. Hum. Genet. 2008)
    526. The presence of DRB1*01 allele in multiple myeloma patients is associated with an indolent disease. (PubMed id 18397187)1, 4 Alcoceba M....GarcA-a-Sanz R. (Tissue Antigens 2008)
    527. The polymorphism of HLA-DR and -DQ allelic genes associated with intrahepatic cholestasis of pregnancy. (PubMed id 18554163)1, 4 Ding Y....Yang X. (Genet. Test. 2008)
    528. Multiple sclerosis in Gypsies from southern Spain: prevalence, mitochondrial DNA haplogroups and HLA class II association. (PubMed id 18312478)1, 4 FernA!ndez O....Leyva L. (Tissue Antigens 2008)
    529. Acute/recent HCV infection. Clinical course, viral replication kunetic and disease outcome. (PubMed id 19124916)1, 4 Tsertsvadze T....Nelson K.E. (Georgian Med News 2008)
    530. HLA class I and class II genotyping in patients with chronic urticaria. (PubMed id 18520158)1, 4 Coban M....Ikbal M. (Int. Arch. Allergy Immunol. 2008)
    531. HLA class II haplotypes distinctly associated with vaso-occlusion in children with sickle cell disease. (PubMed id 18272668)1, 4 Mahdi N....Almawi W.Y. (Clin. Vaccine Immunol. 2008)
    532. Analysis of single nucleotide polymorphisms identifies major type 1A diabetes locus telomeric of the major histocompatibility complex. (PubMed id 18065518)1, 4 Aly T.A....Eisenbarth G.S. (Diabetes 2008)
    533. Association between beta2 adrenergic receptor polymorphisms and rheumatoid arthritis in conjunction with human leukocyte antigen (HLA)-DRB1 shared epitope. (PubMed id 18267980)1, 4 Malysheva O....Baerwald C.G. (Ann. Rheum. Dis. 2008)
    534. Anti-cyclic citrullinated peptide antibody isotypes in rheumatoid arthritis: association with disease duration, rheumatoid factor production and the presence of shared epitope. (PubMed id 18565246)1, 4 Lakos G....Szekanecz Z. (Clin. Exp. Rheumatol. 2008)
    535. Cytokine genotype suggests a role for inflammation in nucleoside analog-associated sensory neuropathy (NRTI-SN) and predicts an individual's NRTI-SN risk. (PubMed id 18240960)1, 4 Cherry C.L....Price P. (AIDS Res. Hum. Retroviruses 2008)
    536. Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis. (PubMed id 18835879)1, 4 Harney S.M....Brown M.A. (Rheumatology (Oxford) 2008)
    537. Comparison of allele frequency for HLA-DR and HLA-DQ between patients with ECC and caries-free children. (PubMed id 18408266)1, 4 Bagherian A....Moheghi N. (J Indian Soc Pedod Prev Dent 2008)
    538. Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis. (PubMed id 18272866)1, 4 De Jager P.L....Ascherio A. (Neurology 2008)
    539. Natural clearance of hepatitis C virus in hemophilia patients. (PubMed id 18277084)1, 4 Simanis R....Viksna L. (Medicina (Kaunas) 2008)
    540. [Clinical outcomes of lamivudine therapy and HLA alleles in chronic hepatitis B patients]. (PubMed id 19096254)1, 4 Oh J.M....Lee K.H. (Korean J Gastroenterol 2008)
    541. Parental transmission of HLA-DRB1*15 in multiple sclerosis. (PubMed id 17972102)1, 4 Ramagopalan S.V....Ebers G.C. (Hum. Genet. 2008)
    542. Association of human leukocyte antigen polymorphism with outcomes of hepatitis B virus infection. (PubMed id 18761557)1, 4 Ramezani A....Velayati A.A. (J. Gastroenterol. Hepatol. 2008)
    543. Genetic polymorphisms at HLA-A, -B, and -DRB1 loci in Han population of Xi'an city in China. (PubMed id 18716994)1, 4 Shen C....Li S. (Croat. Med. J. 2008)
    544. The HLA-DRB1 shared epitope is associated with susceptibility to rheumatoid arthritis in African Americans through European genetic admixture. (PubMed id 18240241)1, 4 Hughes L.B....Bridges S.L. (Arthritis Rheum. 2008)
    545. Association of DRB1 and DQB1 HLA class II polymorphisms in high-grade and neoplastic cervical lesions of women from Argentina. (PubMed id 18820539)1, 4 Eiguchi K....Picconi M.A. (J Low Genit Tract Dis 2008)
    546. Sporadic inclusion body myositis: phenotypic variability and influence of HLA-DR3 in a cohort of 57 Australian cases. (PubMed id 18258695)1, 4 Needham M....Mastaglia F.L. (J. Neurol. Neurosurg. Psychiatr. 2008)
    547. [Screening and analysis of multi-alleles in generalized aggressive periodontitis]. (PubMed id 19031816)1, 4 Wang H.Y. and Pan Y.P. (Zhonghua Kou Qiang Yi Xue Za Zhi 2008)
    548. HLA-DRB1 polymorphisms distribution in chronic dysimmune polyneuropathy. (PubMed id 18789688)1, 4 Gironi M....Nemni R. (Neuromuscul. Disord. 2008)
    549. Association of chest radiography findings with host-related genetic factors in patients with nephropathia epidemica. (PubMed id 17907045)1, 4 Paakkala A....Mustonen J. (Scand. J. Infect. Dis. 2008)
    550. [A role of the HLA-DRB1* genotype in the complex therapy of pulmonary tuberculosis]. (PubMed id 19230187)1, 4 Skvortsova L.A....Archakova L.I. (Probl Tuberk Bolezn Legk 2008)
    551. Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with type 1 autoimmune hepatitis in Japanese. (PubMed id 18371160)1, 4 Umemura T....Kiyosawa K. (Hepatol. Res. 2008)
    552. Anti-glucose-6-phosphate isomerase, anti-cyclic citrullinated peptide antibodies and HLA-DRB1 genotypes in Japanese patients with early rheumatoid arthritis. (PubMed id 19032829)1, 4 Furuya T....Kotake S. (Clin. Exp. Rheumatol. 2008)
    553. Association of Chlamydia pneumoniae infection with HLA-B*35 in patients with coronary artery disease. (PubMed id 17989341)1, 4 Palikhe A....Sinisalo J. (Clin. Vaccine Immunol. 2008)
    554. The HLA-DRB1*1501 allele is prevalent among Japanese patients with anti-glomerular basement membrane antibody-mediated disease. (PubMed id 18413431)1, 4 Kitagawa W....Sugiyama S. (Nephrol. Dial. Transplant. 2008)
    555. Clinical and molecular characteristics of isolated colonic Crohn's disease. (PubMed id 18521924)1, 4 Hancock L....Jewell D. (Inflamm. Bowel Dis. 2008)
    556. Seroprevalence of Helicobacter pylori in Central-European uraemic patients and its possible association with presence of HLA-DR12 allele. (PubMed id 18794605)1, 4 Telkes G....Tulassay Z. (amp 2008)
    557. Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African Americans. (PubMed id 18537178)1, 4 Harris R.A....Chang K.M. (Hepatology 2008)
    558. HLA-DRB1 and multiple sclerosis in Malta. (PubMed id 18057318)1, 4 Dean G....Compston D.A. (Neurology 2008)
    559. Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis: a multicenter study of 664 patients and 1992 healthy controls. (PubMed id 19003916)1, 4 Invernizzi P....Podda M. (Hepatology 2008)
    560. Association of IL23R, TNFRSF1A, and HLA-DRB1*0103 allele variants with inflammatory bowel disease phenotypes in the Finnish population. (PubMed id 18338763)1, 4 Lappalainen M....Paavola-Sakki P. (Inflamm. Bowel Dis. 2008)
    561. Time to seizure occurrence and damage in PROFILE, a multi-ethnic systemic lupus erythematosus cohort. (PubMed id 18372357)1, 4 Ramsey-Goldman R....Kimberly R.P. (Lupus 2008)
    562. Association between the frequency of class II HLA antigens and the susceptibility to intrauterine infection of hepatitis B virus. (PubMed id 18463715)1, 4 Xu Y.Y....Li Q. (Int. J. Biol. Sci. 2008)
    563. [Viral genotype and HLA class II alleles influence on extra-hepatic manifestations of chronic HCV infection]. (PubMed id 18854880)1, 4 Giannitti C....Galeazzi M. (Reumatismo 2008)
    564. Human leukocyte antigen and clinical and demographic characteristics in psoriatic arthritis and psoriasis in Chinese patients. (PubMed id 18381784)1, 4 Liao H.T....Chou C.T. (J. Rheumatol. 2008)
    565. BAT1 promoter polymorphism is associated with rheumatoid arthritis susceptibility. (PubMed id 18381799)1, 4 QuiA+ones-LombraA+a A....Gonzalez S. (J. Rheumatol. 2008)
    566. HLA-DRB1*01 associated with cutaneous hypersensitivity induced by nevirapine and efavirenz. (PubMed id 18301070)1, 4 Vitezica Z.G....Hovnanian A. (AIDS 2008)
    567. Evaluation of HLA-A, -B, -Cw, and -DRB1 alleles frequency in Turkish patients with nasal polyposis. (PubMed id 18922348)1, 4 Keles B....Ozer B. (Otolaryngol Head Neck Surg 2008)
    568. T-cell reactivity to insulin peptide A1-12 in children with recently diagnosed type 1 diabetes or multiple beta-cell autoantibodies. (PubMed id 18565729)1, 4 Marttila J....Ilonen J. (J. Autoimmun. 2008)
    569. Case-control study of the association between select HLA genes and anti-erythropoietin antibody-positive pure red-cell aplasia. (PubMed id 18370845)1, 4 Fijal B....Cohen N. (Pharmacogenomics 2008)
    570. Association of the TRAF1-C5 locus on chromosome 9 with juvenile idiopathic arthritis. (PubMed id 18576341)1, 4 Behrens E.M....Hakonarson H. (Arthritis Rheum. 2008)
    571. A population-specific diabetogenic haplotype HLA-A2,Cw1,B56,DR4,DQ8 is associated with high birthweight in Finnish diabetic families. (PubMed id 18273034)1, 4 JAorvinen T.M....Tuomilehto J. (Genes Immun. 2008)
    572. Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population. (PubMed id 18058064)1, 4 Kamatani Y....Nakamura Y. (J. Hum. Genet. 2008)
    573. MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. (PubMed id 18305173)1, 2 De Gassart A.... Gatti E. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    574. HLA-A33 is associated with susceptibility to enterovirus 71 infection. (PubMed id 19047245)1, 4 Chang L.Y....Huang L.M. (Pediatrics 2008)
    575. HLA profile in patients with AIDS and tuberculosis. (PubMed id 19030725)1, 4 Figueiredo J.F....Donadi E.A. (Braz J Infect Dis 2008)
    576. Antibodies against mutated citrullinated vimentin are a better predictor of disease activity at 24 months in early rheumatoid arthritis than antibodies against cyclic citrullinated peptides. (PubMed id 18398946)1, 4 Innala L....Dahlqvst S.R. (J. Rheumatol. 2008)
    577. Early onset of polyglandular failure is associated with HLA-DRB1*03. (PubMed id 18390988)1, 4 Dittmar M....Kahaly G.J. (Eur. J. Endocrinol. 2008)
    578. Haplotype-specific pattern of association of human major histocompatibility complex with non-Hodgkin's lymphoma outcome. (PubMed id 17971052)1, 4 Nowak J....Warzocha K. (Tissue Antigens 2008)
    579. [Human leukocyte antigen genes to genetic predisposition in diffuse panbronchiolitis]. (PubMed id 18846964)1, 4 Shen C. and She J. (Zhonghua Jie He He Hu Xi Za Zhi 2008)
    580. EVI5 is a risk gene for multiple sclerosis. (PubMed id 18401352)1, 4 Hoppenbrouwers I.A....Hintzen R.Q. (Genes Immun. 2008)
    581. Genetic variation in nitric oxide synthase 2A (NOS2A) and risk for multiple sclerosis. (PubMed id 18580885)1, 4 Barcellos L.F....Oksenberg J.R. (Genes Immun. 2008)
    582. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. (PubMed id 18252895)1, 4 Erlich H....Moonsamy P. (Diabetes 2008)
    583. Methylenetetrahydrofolate reductase 677 T allele protects against persistent HBV infection in West Africa. (PubMed id 18222012)1, 4 Bronowicki J.P....GuAcant J.L. (J. Hepatol. 2008)
    584. The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes. (PubMed id 18487476)1, 4 Fourlanos S....Harrison L.C. (Diabetes Care 2008)
    585. Association between radiographic severity of rheumatoid arthritis and shared epitope alleles: differing mechanisms of susceptibility and protection. (PubMed id 17901090)1, 4 Mewar D....Wilson A.G. (Ann. Rheum. Dis. 2008)
    586. Human leukocyte antigen-A, -B, and -DRB1 haplotypes of cord blood units in the Tzu Chi Taiwan Cord Blood Bank. (PubMed id 18582515)1, 4 Wen S.H....Yang K.L. (Hum. Immunol. 2008)
    587. [Allele and haplotype frequencies of human leukocyte antigen-A, -B, and -DR loci in Koreans: DNA typing of 1,500 cord blood units]. (PubMed id 19127112)1, 4 Whang D.H....Hong H.K. (Korean J Lab Med 2008)
    588. HLA-DRB1 alleles influence clinical phenotypes in Japanese patients with ulcerative colitis. (PubMed id 18416774)1, 4 Matsumura Y....Shimosegawa T. (Tissue Antigens 2008)
    589. Associations of erosive arthritis with anti-cyclic citrullinated peptide antibodies and MHC Class II alleles in systemic lupus erythematosus. (PubMed id 18085741)1, 4 Chan M.T....McHugh N.J. (J. Rheumatol. 2008)
    590. Progression to type 1 diabetes and autoantibody positivity in relation to HLA-risk genotypes in children participating in the ABIS study. (PubMed id 18331414)1, 4 Gullstrand C....Ludvigsson J. (Pediatr Diabetes 2008)
    591. Two single nucleotide polymorphisms identify the highest-risk diabetes HLA genotype: potential for rapid screening. (PubMed id 18694972)1, 4 Barker J.M....Eisenbarth G.S. (Diabetes 2008)
    592. Interaction between polymorphisms of the human leukocyte antigen and HPV-16 variants on the risk of invasive cervical cancer. (PubMed id 18721466)1, 4 de Araujo Souza P.S....Villa L.L. (BMC Cancer 2008)
    593. HLA-A, B, Cw, DRB1, DQB1 and DPB1 alleles and haplotypes in the genetically homogenous Irish population. (PubMed id 18976432)1, 4 Dunne C....Lawlor E. (Int. J. Immunogenet. 2008)
    594. [The relationship between alpha-IFN anti-virus treatment and HLA-DRB1*11 gene mononucleotide polymorphism]. (PubMed id 18822201)1, 4 Chang J.B....Zhao W. (Zhonghua Gan Zang Bing Za Zhi 2008)
    595. Associations of human leukocyte antigen DRB with resistance or susceptibility to HIV-1 infection in the Pumwani Sex Worker Cohort. (PubMed id 18520346)1, 4 Lacap P.A....Plummer F.A. (AIDS 2008)
    596. HLA polymorphism and early rheumatoid arthritis in the Moroccan population. (PubMed id 18801688)1, 4 Atouf O....Essakali M. (Joint Bone Spine 2008)
    597. Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes. (PubMed id 18356404)1, 4 Vehik K....Dabelea D. (Diabetes Care 2008)
    598. A functional haplotype and expression of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Chinese. (PubMed id 18764812)1, 4 Fan L.Y....Han J. (Tissue Antigens 2008)
    599. Reevaluation of human leukocyte antigen DR-DQ haplotype and genotype in type 1 diabetes in the Japanese population. (PubMed id 18259107)1, 4 Katahira M....Nishisaki T. (Horm. Res. 2008)
    600. Association of human leukocyte antigen-DRB1 alleles with disease susceptibility and severity of aplastic anemia in Korean patients. (PubMed id 18571007)1, 4 Song E.Y....Park M.H. (Hum. Immunol. 2008)
    601. Associations between serum anti-CCP antibody, rheumatoid factor levels and HLA-DR4 expression in Hungarian patients with rheumatoid arthritis. (PubMed id 18300568)1, 4 KapitA!ny A....Szekanecz Z. (Isr. Med. Assoc. J. 2008)
    602. SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. (PubMed id 17971048)1, 4 Burfoot R.K....Rubio J.P. (Tissue Antigens 2008)
    603. [Association of HLA-A, B and DRB1 alleles with leukemia in Han population in Hunan Province]. (PubMed id 18583252)1, 4 Luo Q.Z....Yu P. (Nan Fang Yi Ke Da Xue Xue Bao 2008)
    604. Human leucocyte antigen and TNFalpha polymorphism association in microscopic colitis. (PubMed id 18334870)1, 4 Koskela R.M....Karttunen R.A. (amp 2008)
    605. Anti-cofactor autoantibodies in systemic lupus erythematosus: prevalence, clinical and HLA class II associations. (PubMed id 18569076)1, 4 Sebastiani G.D....Galeazzi M. (Immunol. Invest. 2008)
    606. Share epitope, citrullinated cyclic peptide antibodies and smoking in Brazilian rheumatoid arthritis patients. (PubMed id 18270855)1, 4 Oliveira R.D....Louzada-Junior P. (amp 2008)
    607. Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus. (PubMed id 18309376)1, 4 Lee H.S....Gregersen P.K. (Mol. Med. 2008)
    608. Human leukocyte antigen DRB1 alleles predict risk and disease progression of immunoglobulin A nephropathy in Han Chinese. (PubMed id 18367833)1, 4 Cao H.X....Yu X.Q. (Am. J. Nephrol. 2008)
    609. Development and clinical evaluation of a microarray for HLA-A and -DRB1 genotyping. (PubMed id 19000142)1, 4 Lee K.R....Oh H.B. (Tissue Antigens 2008)
    610. Interleukin-1 promoter region polymorphism role in rheumatoid arthritis: a meta-analysis of IL-1B-511A/G variant reveals association with rheumatoid arthritis. (PubMed id 18838388)1, 4 Harrison P....Wordsworth B.P. (Rheumatology (Oxford) 2008)
    611. Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2. (PubMed id 18504544)1, 4 Williams A.J....Bingley P.J. (Diabetologia 2008)
    612. Association of smoking behavior with an odorant receptor allele telomeric to the human major histocompatibility complex. (PubMed id 18939942)1, 4 Santos P.S....Ziegler A. (Genet. Test. 2008)
    613. Frequencies of HLA-DRB1 in Iranian normal population and in patients with acute lymphoblastic leukemia. (PubMed id 18164964)1, 4 Yari F....Talebian A. (Arch. Med. Res. 2008)
    614. Association of leprosy with HLA-DRB1 in an Argentinean population. (PubMed id 18275683)1, 4 BorrA!s S.G....Racca A. (Ann. Clin. Biochem. 2008)
    615. HLA and environmental interactions in sarcoidosis. (PubMed id 19382531)1, 4 Rossman M.D....Monos D. (Sarcoidosis Vasc Diffuse Lung Dis 2008)
    616. Genetic contribution of the CD14 -159C/T dimorphism in the promoter region in Japanese RA. (PubMed id 18565258)1, 4 Takeuchi F....Matsuta K. (Clin. Exp. Rheumatol. 2008)
    617. Association of aplastic anaemia and Fanconi's disease with HLA-DRB1 alleles. (PubMed id 19046304)1, 4 Yari F....Talebian A. (Int. J. Immunogenet. 2008)
    618. Frequency of concurrent autoimmune disorders in patients with autoimmune hepatitis: effect of age, gender, and genetic background. (PubMed id 18223493)1, 4 Bittencourt P.L....Carrilho F.J. (J. Clin. Gastroenterol. 2008)
    619. Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice. (PubMed id 18779568)1, 4 Menconi F....Tomer Y. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    620. Nephropathy in type 1 diabetes is diminished in carriers of HLA-DRB1*04: the genetics of kidneys in diabetes (GoKinD) study. (PubMed id 18039812)1, 4 Cordovado S.K....Mueller P.W. (Diabetes 2008)
    621. HLA-DQB1*05 association with Hashimoto's thyroiditis in children of Northern Greek origin. (PubMed id 18599937)1, 4 Giza S....Goulis D. (Indian Pediatr 2008)
    622. HLA-A, -B and -DRB1 allele frequencies in the Bangladeshi population. (PubMed id 18721271)1, 4 Ali M.E....Rahman M.H. (Tissue Antigens 2008)
    623. Human leukocyte antigen class II association with spontaneous recovery from hepatitis B virus infection in Koreans: analysis at the haplotype level. (PubMed id 18955791)1, 4 Cho S.W....Lee K.W. (J. Korean Med. Sci. 2008)
    624. Parental non-inherited HLA resistance alleles do not confer protection against multiple sclerosis. (PubMed id 18433881)1, 4 Ramagopalan S.V....Ebers G.C. (J. Neuroimmunol. 2008)
    625. Susceptibility to and severity of tuberculosis is genetically controlled by human leukocyte antigens. (PubMed id 18998014)1, 4 Harfouch-Hammoud E.I. and Daher N.A. (Saudi Med J 2008)
    626. Risk factors associated with different stages of atherosclerosis in Colombian patients with rheumatoid arthritis. (PubMed id 18395773)1, 4 Rojas-Villarraga A....Anaya J.M. (Semin. Arthritis Rheum. 2008)
    627. Polymorphism of HLA-DRB1, -DQB1 and -DPB1 genes in Bai ethnic group in southwestern China. (PubMed id 18778327)1, 4 Hu W....Xiao C. (Tissue Antigens 2008)
    628. Human leucocyte antigen class II association in idiopathic bronchiectasis, a disease of chronic lung infection, implicates a role for adaptive immunity. (PubMed id 18241227)1, 4 Boyton R.J....Altmann D.M. (Clin. Exp. Immunol. 2008)
    629. HLA class II alleles specify phenotypes of ketosis-prone diabetes. (PubMed id 18316396)1, 4 Nalini R....Balasubramanyam A. (Diabetes Care 2008)
    630. Association between Cryptosporidium infection and human leukocyte antigen class I and class II alleles. (PubMed id 18248305)1, 4 Kirkpatrick B.D....Petri W.A. (J. Infect. Dis. 2008)
    631. Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes. (PubMed id 18332098)1, 4 Field S.F....Todd J.A. (Diabetes 2008)
    632. Identification of a novel risk locus for multiple sclerosis at 13q31.3 by a pooled genome-wide scan of 500,000 single nucleotide polymorphisms. (PubMed id 18941528)1, 4 Comabella M....Martin R. (PLoS ONE 2008)
    633. HLA-DQ and susceptibility to celiac disease: evidence for gender differences and parent-of-origin effects. (PubMed id 18177450)1, 4 Megiorni F....Mazzilli M.C. (Am. J. Gastroenterol. 2008)
    634. Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis. (PubMed id 17505501)1, 4 Kindmark A....March R.E. (Pharmacogenomics J. 2008)
    635. Association of HLA DRB1-DQA1-DQB1 haplotypes with rheumatic heart disease in Taiwan. (PubMed id 17673320)1, 4 Chou H.T....Chang K.C. (Int. J. Cardiol. 2008)
    636. Anti-SSB/La antibody is negatively associated with HLA-DR2 in chronic hepatitis C infection. (PubMed id 17992468)1, 4 Wu C.S....Hsu P.N. (Clin. Rheumatol. 2008)
    637. Auto-antibodies, HLA and PTPN22: susceptibility markers for rheumatoid arthritis. (PubMed id 18156150)1, 4 Orozco G....MartA-n J. (Rheumatology (Oxford) 2008)
    638. Sarcoidosis in patients with mixed connective tissue disease: clinical, genetic, serological and histological observations. (PubMed id 18196245)1, 4 Szodoray P....Bodolay E. (Rheumatol. Int. 2008)
    639. Interaction of NK inhibitory receptor genes with HLA-C and MHC class II alleles in Hepatitis C virus infection outcome. (PubMed id 18289678)1, 4 Romero V....Yunis E.J. (Mol. Immunol. 2008)
    640. HLA haplotypes in recurrent aphthous stomatitis: a mode of inheritance? (PubMed id 19046300)1, 4 Albanidou-Farmaki E....Parapanissiou E. (Int. J. Immunogenet. 2008)
    641. Association of narcolepsy-cataplexy with HLA-DRB1 and DQB1 in Mexican patients: a relationship between HLA and gender is suggested. (PubMed id 18706091)1, 4 Alaez C....Gorodezky C. (BMC Med. Genet. 2008)
    642. Genetic distinctions and clinical characteristics of type 1 autoimmune hepatitis in Taiwan. (PubMed id 18613417)1, 4 Huang H.C....Lee S.D. (Hepatogastroenterology 2008)
    643. Evidence for HLA class II susceptible and protective haplotypes for osteomyelitis in pediatric patients with sickle cell anemia. (PubMed id 18312480)1, 4 Al-Ola K....Almawi W.Y. (Tissue Antigens 2008)
    644. HLA-DQ3 is a probable risk factor for CMV infection in high-risk kidney transplant patients. (PubMed id 18332066)1, 4 Varga M....JA!ray J. (Nephrol. Dial. Transplant. 2008)
    645. HLA and response to booster hepatitis B vaccination in anti-HBs-seronegative adolescents who had received primary infantile vaccination. (PubMed id 18501999)1, 4 Lin H.H....Wang L.Y. (Vaccine 2008)
    646. Pemphigus and HLA in Morocco. (PubMed id 18036860)1, 4 Brick C....Essakalli M. (Transfus Clin Biol 2007)
    647. Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis. (PubMed id 17383044)1, 4 Karlsen T.H....Lie B.A. (J. Hepatol. 2007)
    648. Contribution of MHC class I region to genetic susceptibility for giant cell arteritis. (PubMed id 17003171)1, 4 Gonzalez-Gay M.A....MartA-n J. (Rheumatology (Oxford) 2007)
    649. Association of HLA-DRB1*13 and TNF-alpha gene polymorphisms with clearance of chronic hepatitis B infection and risk of hepatocellular carcinoma in Thai population. (PubMed id 18070287)1, 4 Kummee P....Hirankarn N. (J. Viral Hepat. 2007)
    650. MHC haplotype matching for unrelated hematopoietic cell transplantation. (PubMed id 17378697)1, 4 Petersdorf E.W....Guo Z. (PLoS Med. 2007)
    651. Influence of HLA alleles on shedding of Kaposi sarcoma-associated herpesvirus in saliva in an African population. (PubMed id 17299710)1, 4 Alkharsah K.R....Schulz T.F. (J. Infect. Dis. 2007)
    652. [Genetic susceptibility to Andes Hantavirus: Association between severity of disease and HLA alA-eles in Chilean patients]. (PubMed id 17989838)1, 4 Ferrer C P....Llop R E. (Rev Chilena Infectol 2007)
    653. Using the maternal-fetal genotype incompatibility test to assess non-inherited maternal HLA-DRB1 antigen coding alleles as rheumatoid arthritis risk factors. (PubMed id 18466466)1, 4 Hsieh H.J....Sinsheimer J.S. (BMC Proc 2007)
    654. Genetic control of immune response in carriers of the 8.1 ancestral haplotype: correlation with levels of IgG subclasses: its relevance in the pathogenesis of autoimmune diseases. (PubMed id 17911430)1, 4 Candore G....Caruso C. (Ann. N. Y. Acad. Sci. 2007)
    655. HLA alleles in Korean patients with Takayasu arteritis. (PubMed id 17428358)1, 4 Lee S.W....Lee S.K. (Clin. Exp. Rheumatol. 2007)
    656. The association of HLA-DRB1 alleles with rheumatoid arthritis in the Chinese Shantou population: a follow-up study. (PubMed id 17534404)1, 4 Lin L....Yang Z. (Biochem. Cell Biol. 2007)
    657. HLA class I and class II frequencies in patients with sarcoidosis from Croatia: role of HLA-B8, -DRB1*0301, and -DQB1*0201 haplotype in clinical variations of the disease. (PubMed id 17767551)1, 4 GrubiA8 Z....Kerhin-BrkljaciA8 V. (Tissue Antigens 2007)
    658. Immunogenetics of HLA class II in Israeli patients with adult-onset type 1 diabetes mellitus. (PubMed id 17584585)1, 4 Hirsch D....Singer J. (Hum. Immunol. 2007)
    659. HLA- A, B, DR and DQ alleles study in Tunisian patients with atopic dermatitis. (PubMed id 18236804)1, 4 Affes H....Makni H. (Tunis Med 2007)
    660. HLA-DRB1*03 is a susceptibility gene in patients with Graves' disease with and without ophthalmopathy. (PubMed id 17284224)1, 4 Yarman S....Carin M. (Int. J. Immunogenet. 2007)
    661. Association between HLA-DRB1*01 and HLA-Cw*08 and outcome following HTLV-I infection. (PubMed id 17652849)1, 4 Rafatpanah H....Hutchinson I. (Iran J Immunol 2007)
    662. Human leukocyte antigen (HLA) class I and II alleles in Turkish patients with rheumatic heart disease. (PubMed id 17578051)1, 4 GA1ndogdu F....Senocak H. (J. Heart Valve Dis. 2007)
    663. Low frequency of the disease-associated DRB1*15-DQB1*06 haplotype may contribute to the low prevalence of multiple sclerosis in Sami. (PubMed id 17389012)1, 4 Harbo H.F....Thorsby E. (Tissue Antigens 2007)
    664. An association analysis of the HLA gene region in latent autoimmune diabetes in adults. (PubMed id 17143607)1, 4 Desai M....Clark A. (Diabetologia 2007)
    665. Low-risk HLA genotype in Type 1 diabetes is associated with less destruction of pancreatic B-cells 12 months after diagnosis. (PubMed id 17971177)1, 4 Spoletini M....Buzzetti R. (Diabet. Med. 2007)
    666. Association of HLA-*08:DRB1*03 with immunoglobulin A-deficiency. (PubMed id 18057683)1, 4 Czyzewska-BuczyA+ska A....Jankowski A. (Indian J Pediatr 2007)
    667. The impact of HLA-A and -DRB1 on age at onset, disease course and severity in Scandinavian multiple sclerosis patients. (PubMed id 17662002)1, 4 Smestad C....Harbo H.F. (Eur. J. Neurol. 2007)
    668. High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism. (PubMed id 17554059)1, 4 Kawase T....Sasazuki T. (Blood 2007)
    669. HLA-A, -B, -C, and -DRB1 allele frequencies in Cuban individuals with antecedents of dengue 2 disease: advantages of the Cuban population for HLA studies of dengue virus infection. (PubMed id 17509453)1, 4 Sierra B....GuzmA!n M.G. (Hum. Immunol. 2007)
    670. [Association of HLA-DRB1 and -DPB1 allele polymorphism with multiple sclerosis in Chinese Han population from Southern areas]. (PubMed id 18167262)1, 4 Wu X.M....Xie X.F. (Zhonghua Yi Xue Za Zhi 2007)
    671. Butyrophilin-like 2 gene is associated with ulcerative colitis in the Japanese under strong linkage disequilibrium with HLA-DRB1*1502. (PubMed id 17610417)1, 4 Mochida A....Shimosegawa T. (Tissue Antigens 2007)
    672. The relationship between HLA-DRB1 alleles and optic neuritis in Irish patients and the risk of developing multiple sclerosis. (PubMed id 17895416)1, 4 Tuwir I....Cassidy L. (Br J Ophthalmol 2007)
    673. Evidence for human leukocyte antigen heterozygote advantage against hepatitis C virus infection. (PubMed id 17935228)1, 4 Hraber P....Yusim K. (Hepatology 2007)
    674. Human leukocyte antigen (HLA) class II association with rheumatic heart disease in Pakistan. (PubMed id 17578052)1, 4 Rehman S....Mohyuddin A. (J. Heart Valve Dis. 2007)
    675. [Analysis of occurrence of DRB and DQ alleles in sarcoidosis and tuberculosis from Northern Poland]. (PubMed id 17541908)1, 4 Dubaniewicz A. and Moszkowska G. (Pneumonol Alergol Pol 2007)
    676. [Expression of HLA-DRB1*15 genotype in children with acquired aplastic anemia and its relation to effect of immunosuppressive therapy]. (PubMed id 18088469)1, 4 Huang Y.L....Bao R. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2007)
    677. Human leukocyte antigen class II alleles and risk of cervical cancer in China. (PubMed id 17349874)1, 4 Wu Y....Xu A. (Hum. Immunol. 2007)
    678. Association between hepatic alveolar echinococcosis and frequency of human leukocyte antigen class I and II alleles in Turkish patients. (PubMed id 17573956)1, 4 Aydinli B....Donmez R. (Hepatol. Res. 2007)
    679. HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY population. (PubMed id 17513705)1, 4 Baschal E.E....Eisenbarth G.S. (Diabetes 2007)
    680. Association between HLA-DRB1 polymorphism, high-risk HPV infection and cervical neoplasia in southern Chinese. (PubMed id 17516530)1, 4 Chan P.K....Tang J.W. (J. Med. Virol. 2007)
    681. HLA-DR15 haplotype and multiple sclerosis: a HuGE review. (PubMed id 17329717)1, 4 Schmidt H....Ashley-Koch A. (Am. J. Epidemiol. 2007)
    682. Multiple sclerosis immunopathic trait and HLA-DR(2)15 as independent risk factors in multiple sclerosis. (PubMed id 17463066)1, 4 Callander M....Andersen O. (Mult. Scler. 2007)
    683. The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide. (PubMed id 17265477)1, 4 van der Helm-van Mil A.H....Toes R.E. (Arthritis Rheum. 2007)
    684. HLA-B*1301 as a biomarker for genetic susceptibility to hypersensitivity dermatitis induced by trichloroethylene among workers in China. (PubMed id 18007983)1, 4 Li H....Zheng Y. (Environ. Health Perspect. 2007)
    685. HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap. (PubMed id 18003662)1, 4 Wedderburn L.R....Davidson J.E. (Rheumatology (Oxford) 2007)
    686. Psoriasis vulgaris and human leukocyte antigens. (PubMed id 17309450)1, 4 Cassia F.F....Porto L.C. (J Eur Acad Dermatol Venereol 2007)
    687. Ethnicity-dependent association of HLA DRB1-DQA1-DQB1 alleles in Brazilian multiple sclerosis patients. (PubMed id 17489940)1, 4 Alves-Leon S.V....FernA!ndez y Fernandez O. (Acta Neurol. Scand. 2007)
    688. Analysis of extended human leukocyte antigen haplotype association with Addison's disease in three populations. (PubMed id 18057383)1, 4 Gombos Z....Ilonen J. (Eur. J. Endocrinol. 2007)
    689. Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger disease. (PubMed id 17653770)1, 4 Chen Z....Kimura A. (Hum. Genet. 2007)
    690. Different HLA class II associations in ulcerative colitis patients with and without primary sclerosing cholangitis. (PubMed id 17301827)1, 4 Karlsen T.H....Lie B.A. (Genes Immun. 2007)
    691. HLA polymorphisms and cervical human Papillomavirus infection in a cohort of Montreal University students. (PubMed id 17538887)1, 4 Mahmud S.M....Franco E.L. (J. Infect. Dis. 2007)
    692. HLA-DRB1* alleles in Egyptian children with post-streptococcal acute glomerulonephritis. (PubMed id 17106689)1, 4 Bakr A....Salah A. (Pediatr. Nephrol. 2007)
    693. HLA-DRB1*0402 haplotypes without DQB1*0302 in Venezuelan patients with pemphigus vulgaris. (PubMed id 17389015)1, 4 SA!enz-Cantele A.M....Layrisse Z. (Tissue Antigens 2007)
    694. Influence of HLA-DR2 on perforin-positive cells in pulmonary tuberculosis. (PubMed id 17845310)1, 4 Rajeswari D.N....Narayanan P.R. (Int. J. Immunogenet. 2007)
    695. [Study on the association between the HLA-DRB1 alleles and type 2 diabetes in Yi nationality of Yunnan]. (PubMed id 17285557)1, 4 Yang H.Y....He W. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007)
    696. [Study on the relationship between chronic glomerulonephritis and human leukocyte antigen in Shandong province]. (PubMed id 18399156)1, 4 Zhao J.J....Zhang C. (Zhonghua Liu Xing Bing Xue Za Zhi 2007)
    697. An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus. (PubMed id 18087043)1, 4 DeLuca G.C....Ebers G.C. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    698. Autoantibody epitopes to the smaller isoform of glutamate decarboxylase do not differ in Swedish and Japanese type 1 diabetes patients and may be associated with high-risk human leucocyte antigen class II alleles. (PubMed id 17956579)1, 4 Maruyama T....Hampe C.S. (Clin. Exp. Immunol. 2007)
    699. B-cell numbers in the blood of patients with non-HLA*B8 or non-HLA*B44 common variable immunodeficiency. (PubMed id 17304884)1, 4 Johnston D.T. and Schroeder H.W. (amp 2007)
    700. [Study on correlation between HLA-A, B, DR alleles and Duchenne muscular dystrophy]. (PubMed id 17922429)1, 4 Chen W....Wu H.L. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007)
    701. [Association of polymorphism on HLA-DRB1*04 alleles with outcome of hepatitis B virus infection]. (PubMed id 17680546)1, 4 Song M.S....Xu L.Q. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007)
    702. HLA class II allele and haplotype frequencies in Iranian patients with leukemia. (PubMed id 17893434)1, 4 Khosravi F....Nikbin B. (Iran J Allergy Asthma Immunol 2007)
    703. Risk of progression from undifferentiated arthritis to rheumatoid arthritis: the effect of the PTPN22 1858T-allele in anti-citrullinated peptide antibody positive patients. (PubMed id 17341507)1, 4 Feitsma A.L....van der Helm-van Mil A.H. (Rheumatology (Oxford) 2007)
    704. Association of HLA class II allele and haplotype frequencies with chronic myelogenous leukemia and age-at-onset of the disease. (PubMed id 17387388)1, 4 Amirzargar A.A....Nikbin B. (Pathol. Oncol. Res. 2007)
    705. No evidence for multiple loci affecting rheumatoid arthritis risk on chromosome 6p21. (PubMed id 18466541)1, 4 Sherva R....Neuman R. (BMC Proc 2007)
    706. Antinuclear antibodies and HLA class II alleles in Jamaican patients with systemic lupus erythematosus. (PubMed id 17910142)1, 4 Christian N....Barton E.N. (West Indian Med J 2007)
    707. The inheritance of resistance alleles in multiple sclerosis. (PubMed id 17845076)1, 4 Ramagopalan S.V....Ebers G.C. (PLoS Genet. 2007)
    708. SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients. (PubMed id 17554341)1, 4 Sedimbi S.K....Aman J. (Genes Immun. 2007)
    709. HLA class II polymorphisms associated with the physiologic characteristics defined by Traditional Chinese Medicine: linking modern genetics with an ancient medicine. (PubMed id 17388766)1, 4 Chen S....Xu A. (J Altern Complement Med 2007)
    710. Genetic contribution of major histocompatibility complex class II region to type 1 autoimmune hepatitis susceptibility in Venezuela. (PubMed id 17927716)1, 4 Fortes M.d.e.l. .P....Tassinari P. (Liver Int. 2007)
    711. Roles of DRB1 *1501 and DRB1 *1502 in the pathogenesis of aplastic anemia. (PubMed id 17198869)1, 4 Sugimori C....Nakao S. (Exp. Hematol. 2007)
    712. Polymorphism between loci for human leukocyte antigens DR and DQ in patients with nasal polyps. (PubMed id 17305280)1, 4 Zhai L....Liu H. (Ann. Otol. Rhinol. Laryngol. 2007)
    713. Influence of HLA-DRB1 alleles on Th1 and Th2 cytokine response to Mycobacterium tuberculosis antigens in pulmonary tuberculosis. (PubMed id 17826339)1, 4 Selvaraj P....Narayanan P.R. (Tuberculosis (Edinb) 2007)
    714. Cerebral cavernomas and human leukocyte antigens: preliminary clinical results. (PubMed id 17662350)1, 4 Sanus G.Z....Kaynar M.Y. (Surg Neurol 2007)
    715. Familial clustering of multiple sclerosis in a Dutch genetic isolate. (PubMed id 17294607)1, 4 Hoppenbrouwers I.A....Hintzen R.Q. (Mult. Scler. 2007)
    716. [The study on relation of HLA-DRB1 gene polymorphism to Keshan disease and its association and linkage in the core families]. (PubMed id 17285554)1, 4 Wei J....Zhu J.H. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007)
    717. [Correlation of HLA-alleles with aplastic anemia]. (PubMed id 18088468)1, 4 Liang X.L....Li Q. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2007)
    718. Relationship between HLA polymorphisms and gamma interferon and interleukin-10 cytokine production in healthy individuals after rubella vaccination. (PubMed id 17215337)1, 4 Ovsyannikova I.G....Poland G.A. (Clin. Vaccine Immunol. 2007)
    719. HLA alleles as predisposal factors for postmenopausal osteoporosis in a Greek population. (PubMed id 17498269)1, 4 Douroudis K....Papasteriades C.h. (Tissue Antigens 2007)
    720. [Genetic HLA markers associated with pulmonary tuberculosis in the Barum-Khemchiksky District, Republic of Tyva]. (PubMed id 17672065)1, 4 Pospelov L.E....Zhachin A.A. (Probl Tuberk Bolezn Legk 2007)
    721. Association analysis in type 1 diabetes of the PRSS16 gene encoding a thymus-specific serine protease. (PubMed id 17584581)1, 4 Lie B.A....Undlien D.E. (Hum. Immunol. 2007)
    722. The association of DRB1*04 share epitope alleles and tumor necrosis factor-alpha gene polymorphism (-863) with susceptibility to rheumatoid arthritis in Thai. (PubMed id 17589850)1, 4 Hirankarn N....Charoenwongse P. (Rheumatol. Int. 2007)
    723. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. (PubMed id 17632545)1, 4 Hakonarson H.... Polychronakos C. (Nature 2007)
    724. HLA and MICA associations with head and neck squamous cell carcinoma. (PubMed id 16857416)1, 4 Reinders J....Tilanus M.G. (Oral Oncol. 2007)
    725. HLA-associated genetic resistance and susceptibility to type I diabetes in French North Africans and French natives. (PubMed id 17661909)1, 4 GuAcrin V....Sterkers G. (Tissue Antigens 2007)
    726. A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene. (PubMed id 17334650)1, 4 Howson J.M....Todd J.A. (Diabetologia 2007)
    727. Chronic hepatitis C infection and sicca syndrome: a clear association with HLA DQB1*02. (PubMed id 17489060)1, 4 Smyth C.M....Kelleher D. (amp 2007)
    728. [ssociation of HLA class I and II alleles with generalized vitiligo in Chinese Hans in north China]. (PubMed id 17407088)1, 4 Wang J....Chen H.D. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007)
    729. Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types. (PubMed id 17437273)1, 4 Goedert J.J....Hisada M. (Int. J. Cancer 2007)
    730. Human leukocyte antigens HLA DRB1 influence clinical outcome of chronic lymphocytic leukemia? (PubMed id 17488703)1, 4 Lech-Maranda E....Robak T. (Haematologica 2007)
    731. Analysis of BTNL2 genetic polymorphisms in British and Dutch patients with sarcoidosis. (PubMed id 17661910)1, 4 Spagnolo P....Welsh K.I. (Tissue Antigens 2007)
    732. Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development. (PubMed id 18077428)1, 4 Feitsma A.L....de Vries R.R. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    733. Association of DRB1 shared epitope genotypes with early mortality in rheumatoid arthritis: results of eighteen years of followup from the early rheumatoid arthritis study. (PubMed id 17469097)1, 4 Mattey D.L....Young A. (Arthritis Rheum. 2007)
    734. Diversity of HLA-DQA1 gene in the Korean population. (PubMed id 17445173)1, 4 Lee K.W....Oh D.H. (Tissue Antigens 2007)
    735. Association of smoking with the constitution of the anti-cyclic citrullinated peptide response in the absence of HLA-DRB1 shared epitope alleles. (PubMed id 17763436)1, 4 Verpoort K.N....Toes R.E. (Arthritis Rheum. 2007)
    736. Human leukocyte antigen class I and class II allele frequencies and HIV-1 infection associations in a Chinese cohort. (PubMed id 17106278)1, 4 Li S....Lu Y. (J. Acquir. Immune Defic. Syndr. 2007)
    737. TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study. (PubMed id 17804836)1, 4 Plenge R.M....Gregersen P.K. (N. Engl. J. Med. 2007)
    738. MICA marks additional risk factors for Type 1 diabetes on extended HLA haplotypes: an association and meta-analysis. (PubMed id 17350686)1, 4 Alizadeh B.Z....Koeleman B.P. (Mol. Immunol. 2007)
    739. MHC class II genes in Mexican patients with idiopathic dilated cardiomyopathy. (PubMed id 17126830)1, 4 RodrA-guez-PAcrez J.M....Vargas-AlarcA^n G. (Exp. Mol. Pathol. 2007)
    740. Differential association of HLA-DRB1 alleles in Japanese patients with early rheumatoid arthritis in relationship to autoantibodies to cyclic citrullinated peptide. (PubMed id 17543145)1, 4 Furuya T....Kotake S. (Clin. Exp. Rheumatol. 2007)
    741. Meta-analysis of HLA-DRB1 polymorphism in Latin American patients with rheumatoid arthritis. (PubMed id 17537386)1, 4 Delgado-Vega A.M. and Anaya J.M. (Autoimmun Rev 2007)
    742. Rheumatoid arthritis association at 6q23. (PubMed id 17982455)1, 4 Thomson W....Worthington J. (Nat. Genet. 2007)
    743. Investigation into the multidimensional genetic basis of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis. (PubMed id 18085998)1, 4 Pirmohamed M....Stern R.S. (Pharmacogenomics 2007)
    744. [Correlation of the polymorphism of HLA-A, B and DRB1 alleles with nasopharyngeal carcinoma in the south of China]. (PubMed id 17825227)1, 4 Zeng X.H....Wang X.N. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007)
    745. Sequence-based typing of HLA-DQA1: comprehensive approach showed molecular heterogeneity. (PubMed id 17445172)1, 4 Voorter C.E....van den Berg-Loonen E.M. (Tissue Antigens 2007)
    746. Genetic insights into the disease mechanisms of type II mixed cryoglobulinemia induced by hepatitis C virus. (PubMed id 17936227)1, 4 De Re V....Dolcetti R. (Dig Liver Dis 2007)
    747. HLA-Cw6 and HLA-DRB1*07 together are associated with less severe joint disease in psoriatic arthritis. (PubMed id 17223660)1, 4 Ho P.Y....Bruce I.N. (Ann. Rheum. Dis. 2007)
    748. Analysis of HLA class I-II haplotype frequency and segregation in a cohort of patients with advanced stage ovarian cancer. (PubMed id 17661908)1, 4 Gamzatova Z....Masucci G.V. (Tissue Antigens 2007)
    749. Identification of two independent risk factors for lupus within the MHC in United Kingdom families. (PubMed id 17997607)1, 4 Fernando M.M....Vyse T.J. (PLoS Genet. 2007)
    750. Improved definition of human leukocyte antigen frequencies among minorities and applicability to estimates of transplant compatibility. (PubMed id 17460569)1, 4 Leffell M.S....Zachary A.A. (Transplantation 2007)
    751. Association of anti-cyclic citrullinated peptide antibody levels with PADI4 haplotypes in early rheumatoid arthritis and with shared epitope alleles in very late rheumatoid arthritis. (PubMed id 17469103)1, 4 Cha S....Bae S.C. (Arthritis Rheum. 2007)
    752. Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis. (PubMed id 17610416)1, 4 Thomson G....Nerup J. (Tissue Antigens 2007)
    753. Is typing for HLA class II alleles beneficial in Indian children with idiopathic nephrotic syndrome? (PubMed id 17180363)1, 4 Gulati S....Agarwal S. (Pediatr. Nephrol. 2007)
    754. HPV16 E6 variants and HLA class II polymorphism among Chinese women with cervical cancer. (PubMed id 17311339)1, 4 Wu Y....Xu A. (J. Med. Virol. 2007)
    755. Association of human leukocyte antigen and T cell message with human papillomavirus 16-positive cervical neoplasia in Japanese women. (PubMed id 17433060)1, 4 Saito M....Maeda H. (Int. J. Gynecol. Cancer 2007)
    756. HLA-DRB1*0101 is associated with the genetic susceptibility to develop lichen planus in the Mexican Mestizo population. (PubMed id 17665209)1, 4 Luis-Montoya P....Granados J. (Arch. Dermatol. Res. 2007)
    757. HLA-DRB4 as a genetic risk factor for Churg-Strauss syndrome. (PubMed id 17763415)1, 4 Vaglio A....Neri T.M. (Arthritis Rheum. 2007)
    758. Clearance and persistence of hepatitis C virus in a Tunisian population: association with HLA class I and class II. (PubMed id 17603847)1, 4 Ksiaa L....Ayed K. (Viral Immunol. 2007)
    759. HLA association is different in children and adults with severe acquired aplastic anemia. (PubMed id 16496287)1, 4 FA1hrer M....Albert E. (amp 2007)
    760. Association between hepatitis B virus infection and HLA-DRB1 genotyping in Shaanxi Han patients in northwestern China. (PubMed id 17257320)1, 4 Yang G....Fan D. (Tissue Antigens 2007)
    761. Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD. (PubMed id 17389014)1, 4 MartA-nez A....Urcelay E. (Tissue Antigens 2007)
    762. [Role of HLA-DR and HLA-DQ alleles in multibacillary leprosy and paucibacillary leprosy in the province of Chaco (Argentina)]. (PubMed id 18053473)1, 4 Motta P.M....Habegger de Sorrentino A. (Enferm. Infecc. Microbiol. Clin. 2007)
    763. HLA class II amino acid epitopes as susceptibility markers of sarcoidosis. (PubMed id 17559577)1, 4 Voorter C.E....van den Berg-Loonen E.M. (Tissue Antigens 2007)
    764. Meta-analysis of the association between HLA-DRB1 allele and rheumatoid arthritis susceptibility in Asian populations. (PubMed id 18162709)1, 4 Jun K.R....Lee K.J. (J. Korean Med. Sci. 2007)
    765. Human leukocyte antigens in undifferentiated spondyloarthritis. (PubMed id 17604825)1, 4 Liao H.T....Chou C.T. (Semin. Arthritis Rheum. 2007)
    766. Childhood asthma and human leukocyte antigen type. (PubMed id 17212706)1, 4 Juhn Y.J....Poland G.A. (Tissue Antigens 2007)
    767. The role of HLA-DRB1 shared epitope alleles in predicting short-term response to leflunomide in rheumatoid arthritis. (PubMed id 18032542)1, 4 Saruhan-Direskeneli G....Direskeneli H. (Rheumatology (Oxford) 2007)
    768. HLA-DRB1*08 allele may help to distinguish between type 1 diabetes mellitus and type 2 diabetes mellitus in Mexican children. (PubMed id 17341285)1, 4 RodrA-guez-Ventura A.L....Granados J. (Pediatr Diabetes 2007)
    769. Association of HLA class II genes with idiopathic pulmonary arterial hypertension in Koreans. (PubMed id 17406941)1, 4 Yoon S.H....Lee S.D. (Lung 2007)
    770. Modeling of PTPN22 and HLA-DRB1 susceptibility to rheumatoid arthritis. (PubMed id 18466483)1, 4 Gagnon F....Tezenas du Montcel S. (BMC Proc 2007)
    771. TNF microsatellites polymorphism is associated with rheumatoid arthritis. Confirming evidence in northwestern Colombians. (PubMed id 17631742)1, 4 Gomez L.M....Anaya J.M. (Clin. Exp. Rheumatol. 2007)
    772. Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis reveals drug-response markers. (PubMed id 17622942)1, 4 Grossman I....Miller A. (Pharmacogenet. Genomics 2007)
    773. Analysis of HLA antigens in Turkish sarcoidosis patients. (PubMed id 17458393)1, 4 Bilir M....Erdogan E. (South. Med. J. 2007)
    774. The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation. (PubMed id 17726164)1, 4 Shaw B.E....Petersdorf E.W. (Blood 2007)
    775. Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes. (PubMed id 17257319)1, 4 Wiencke K....Spurkland A. (Tissue Antigens 2007)
    776. HLA-DRB1*1101 allele may be associated with bilateral MAcniAcre's disease in southern European population. (PubMed id 17592398)1, 4 Lopez-Escamez J.A....Lopez-Nevot M.A. (amp 2007)
    777. Association of human leukocyte antigen ancestral haplotype 8.1 with adverse outcome of non-Hodgkin's lymphoma. (PubMed id 17311253)1, 4 Nowak J....Warzocha K. (amp 2007)
    778. HLA-DRB1*04 and DRB1*10 are associated with resistance and susceptibility, respectively, in Brazilian and Vietnamese leprosy patients. (PubMed id 17396103)1, 4 Vanderborght P.R....Moraes M.O. (Genes Immun. 2007)
    779. Gene-gene and gene-environment interactions involving HLA-DRB1, PTPN22, and smoking in two subsets of rheumatoid arthritis. (PubMed id 17436241)1, 4 Kallberg H....Alfredsson L. (Am. J. Hum. Genet. 2007)
    780. The role of HLA-DRB1 alleles on susceptibility and outcome of a Portuguese Multiple Sclerosis population. (PubMed id 17412364)1, 4 Silva A.M....Martins B. (J. Neurol. Sci. 2007)
    781. Specific combinations of HLA-DR2 and DR3 class II haplotypes contribute graded risk for disease susceptibility and autoantibodies in human SLE. (PubMed id 17406641)1, 4 Graham R.R....Behrens T.W. (Eur. J. Hum. Genet. 2007)
    782. HLA class II DR and DQ genotypes and haplotypes associated with rheumatic fever among a clinically homogeneous patient population of Latvian children. (PubMed id 17559688)1, 4 Stanevicha V....Gardovska D. (amp 2007)
    783. Association of HLA DQ B1* and HLA DR B1* alleles with goitrous juvenile autoimmune hypothyroidism--a case control study. (PubMed id 17588142)1, 4 Rekha P.L....Ishaq M. (J. Clin. Immunol. 2007)
    784. Major histocompatibility complex class II polymorphisms and risk of cervical cancer in Puerto Rican women. (PubMed id 17722421)1, 4 Climent C....Gorbea S. (P R Health Sci J 2007)
    785. HLA genotype and development of gastric cancer in patients with Helicobacter pylori infection. (PubMed id 17629023)1, 4 Hirata I....Katsu K. (Hepatogastroenterology 2007)
    786. HLA-DRB1 alleles in juvenile-onset systemic lupus erythematosus: renal histologic class correlations. (PubMed id 17401504)1, 4 Liphaus B.L....Goldberg A.C. (Braz. J. Med. Biol. Res. 2007)
    787. HLA-DQB1 0602 allele is associated with splenomegaly in Japanese sarcoidosis. (PubMed id 17875181)1, 4 Sato H....Izumi T. (J. Intern. Med. 2007)
    788. Generic human leukocyte antigen class II (DRB1 and DQB1) alleles in patients with paracoccidioidomycosis. (PubMed id 17325942)1, 4 Sadahiro A....Shikanai-Yasuda M.A. (Med. Mycol. 2007)
    789. HLA-DR association with the genetic susceptibility to develop ashy dermatosis in Mexican Mestizo patients. (PubMed id 17116345)1, 4 Correa M.C....Granados J. (J. Am. Acad. Dermatol. 2007)
    790. CD209 in inflammatory bowel disease: a case-control study in the Spanish population. (PubMed id 18070336)1, 4 NA_A+ez C....MartA-n J. (BMC Med. Genet. 2007)
    791. HLA, NFKB1 and NFKBIA gene polymorphism profile in autoimmune diabetes mellitus patients. (PubMed id 17318773)1, 4 Katarina K....Marie C. (amp 2007)
    792. HLA-DRB1 and persistent chronic inflammation contribute to cardiovascular events and cardiovascular mortality in patients with rheumatoid arthritis. (PubMed id 17266100)1, 4 Gonzalez-Gay M.A....Llorca J. (Arthritis Rheum. 2007)
    793. Two critical genes (HLA-DRB1 and ABCF1)in the HLA region are associated with the susceptibility to autoimmune pancreatitis. (PubMed id 17119950)1, 4 Ota M....Kawa S. (Immunogenetics 2007)
    794. HLA-DRB1*1501, -DQB1*0301, -DQB1*0302, -DQB1*0602, and -DQB1*0603 alleles are associated with more severe disease outcome on MRI in patients with multiple sclerosis. (PubMed id 17531857)1, 4 Zivadinov R....Zorzon M. (Int. Rev. Neurobiol. 2007)
    795. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PubMed id 17554300)1, 4 (Nature 2007)
    796. Human MHC region harbors both susceptibility and protective haplotypes for coronary artery disease. (PubMed id 17212707)1, 4 Palikhe A....Lokki M.L. (Tissue Antigens 2007)
    797. Protective effect of HLA-B57 on HCV genotype 2 infection in a West African population. (PubMed id 17546694)1, 4 Chuang W.C....Allain J.P. (J. Med. Virol. 2007)
    798. [The distribution of HLA genes in Russian patients with germ cell tumors]. (PubMed id 18084828)1, 4 Seniuta N.B....Gurtsevich V.E. (Vestn. Akad. Med. Nauk SSSR 2007)
    799. Fetal growth is increased by maternal type 1 diabetes and HLA DR4-related gene interactions. (PubMed id 17310371)1, 4 Hummel M....Ziegler A.G. (Diabetologia 2007)
    800. Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients. (PubMed id 17376212)1, 4 LA^pez-Tello A....Granados J. (Clin. Exp. Dermatol. 2007)
    801. A genome-wide scan in forty large pedigrees with multiple sclerosis. (PubMed id 18000641)1, 4 Willer C.J....Ebers G.C. (J. Hum. Genet. 2007)
    802. Polymorphism of immunoglobulin enhancer element HS1,2A: allele *2 associates with systemic sclerosis. Comparison with HLA-DR and DQ allele frequency. (PubMed id 17392350)1, 4 Frezza D....Ferraccioli G. (Ann. Rheum. Dis. 2007)
    803. Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium. (PubMed id 17584771)1, 4 Chao M.J....Ebers G.C. (Hum. Mol. Genet. 2007)
    804. HLA-DRB1*0404 is strongly associated with anticalpastatin antibodies in rheumatoid arthritis. (PubMed id 17324966)1, 4 Auger I....Roudier J. (Ann. Rheum. Dis. 2007)
    805. Human leukocyte antigen alleles and haplotypes associated with chronicity of hepatitis B virus infection in Koreans. (PubMed id 17227111)1, 4 Hwang S.H....Lee K.J. (amp 2007)
    806. Genome-wide linkage and association analysis of rheumatoid arthritis in a Canadian population. (PubMed id 18466515)1, 4 Wei Z. and Li M. (BMC Proc 2007)
    807. A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for autoantibody production in rheumatoid arthritis. (PubMed id 17328818)1, 4 Gourraud P.A....Constantin A. (amp 2007)
    808. HLA class II haplotype DRB1*04-DQB1*0301 contributes to risk of familial generalized vitiligo and early disease onset. (PubMed id 16420246)1, 4 Fain P.R....Spritz R.A. (Pigment Cell Res. 2006)
    809. HLa-class II (DRB &amp; DQB1) in Thai sudden unexplained death syndrome (Thai SUDS) families (Lai-Tai families). (PubMed id 17124999)1, 4 Himmunngan P....Patmasiriwat P. (Southeast Asian J. Trop. Med. Public Health 2006)
    810. Association of HLA-DR3 and HLA-DR4 with sinonasal polyposis in Mexican Mestizos. (PubMed id 16815190)1, 4 RamA-rez-Anguiano J....Granados J. (Otolaryngol Head Neck Surg 2006)
    811. Relationship between human leucocyte antigen class I and class II and chronic idiopathic urticaria associated with aspirin and/or NSAIDs hypersensitivity. (PubMed id 17392574)1, 4 Pacor M.L....Corrocher R. (Mediators Inflamm. 2006)
    812. Polymorphism of HLA-DR and HLA-DQ in rheumatoid arthritis patients and clinical response to methotrexate--a hospital-based study. (PubMed id 17144392)1, 4 Ali A.A....Iqbal M.P. (J Pak Med Assoc 2006)
    813. HLA-DRB1*04 alleles in Japanese rheumatoid arthritis patients with AA amyloidosis. (PubMed id 17086601)1, 4 Migita K....Eguchi K. (J. Rheumatol. 2006)
    814. HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: a large-scale study. (PubMed id 16941709)1, 4 Donaldson P.T....Bassendine M.F. (Hepatology 2006)
    815. HLA-DRB1 donor-recipient mismatch affects the outcome of hepatitis C disease recurrence after liver transplantation. (PubMed id 16530511)1, 4 Belli L.S....Pinzello G. (Gastroenterology 2006)
    816. Association between HLA class II alleles and autoimmune hepatitis type 1 in Thai patients. (PubMed id 17722299)1, 4 Tanwandee T....Chotiyaputta W. (J Med Assoc Thai 2006)
    817. HLA class II DRB1 polymorphism in Argentinians undergoing chronic Trypanosoma cruzi infection. (PubMed id 16704757)1, 4 GarcA-a BorrA!s S....Racca A. (Ann. Clin. Biochem. 2006)
    818. Combination of HLA-A24, -DQA1*03, and -DR9 contributes to acute-onset and early complete beta-cell destruction in type 1 diabetes: longitudinal study of residual beta-cell function. (PubMed id 16731854)1, 4 Nakanishi K. and Inoko H. (Diabetes 2006)
    819. HLA-class II haplotype associations with ovarian cancer. (PubMed id 17016821)1, 4 KA1bler K....van der Ven K. (Int. J. Cancer 2006)
    820. Polymorphism of the promoter region and exon 1 of the CTLA4 gene in endemic pemphigus foliaceus (fogo selvagem). (PubMed id 16972006)1, 4 Pavoni D.P....Petzl-Erler M.L. (Braz. J. Med. Biol. Res. 2006)
    821. HLA-DRB1 association in Saudi rheumatoid arthritis patients. (PubMed id 16673133)1, 4 Al-Swailem R....Tariq M. (Rheumatol. Int. 2006)
    822. The association between HLA class II haplotype with Graves' disease in Thai population. (PubMed id 16451208)1, 4 Wongsurawat T....Hirankarn N. (Tissue Antigens 2006)
    823. HLA class II allele and haplotype frequencies in iranian patients with acute myelogenous leukemia and control group. (PubMed id 17237562)1, 4 Sarafnejad A....Amirzargar A. (Iran J Allergy Asthma Immunol 2006)
    824. Human leucocyte antigen class II polymorphism in Irish patients with multiple sclerosis. (PubMed id 16948649)1, 4 Dunne C....Lawlor E. (Tissue Antigens 2006)
    825. Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5. (PubMed id 16769963)1, 4 Niks E.H....Verschuuren J.J. (Neurology 2006)
    826. Finnish HLA studies confirm the increased risk conferred by HLA-B27 homozygosity in ankylosing spondylitis. (PubMed id 16249228)1, 4 Jaakkola E....Brown M.A. (Ann. Rheum. Dis. 2006)
    827. Association of HLA subtype DRB10407 in Colombian patients with actinic prurigo. (PubMed id 16606409)1, 4 SuA!rez A....de Porras Quintana L. (amp 2006)
    828. Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis. (PubMed id 16646982)1, 4 Michou L....CornAclis F. (amp 2006)
    829. Clinical behavior of multiple sclerosis is modulated by the MHC class I-chain-related gene A. (PubMed id 16671949)1, 4 Fdez-Morera J.L....Lopez-Larrea C. (Tissue Antigens 2006)
    830. Association of HLA loci alleles and antigens in Saudi patients with vitiligo. (PubMed id 17021767)1, 4 Abanmi A....Tariq M. (Arch. Dermatol. Res. 2006)
    831. IL-10 polymorphisms are associated with early-onset celiac disease and severe mucosal damage in patients of Caucasian origin. (PubMed id 16540751)1, 4 Barisani D....Bardella M.T. (Genet. Med. 2006)
    832. Effects of PTPN22 C1858T polymorphism on susceptibility and clinical characteristics of British Caucasian rheumatoid arthritis patients. (PubMed id 16490755)1, 4 Harrison P....Wordsworth B.P. (Rheumatology (Oxford) 2006)
    833. Class II HLA allele polymorphism: DRB1, DQB1 and DPB1 alleles and haplotypes in the New Zealand Maori population. (PubMed id 17026464)1, 4 Tracey M.C. and Carter J.M. (Tissue Antigens 2006)
    834. HLA-A, -B, -DR and -DQ allele and haplotype frequencies in the Moroccan population: a general population study. (PubMed id 17306585)1, 4 Brick C....Essakalli M. (Transfus Clin Biol 2006)
    835. Human leukocyte antigen distribution analysis in North Italian brain Glioma patients: an association with HLA-DRB1*14. (PubMed id 16314951)1, 4 Guerini F.R....Ferrante P. (J. Neurooncol. 2006)
    836. Extreme genetic risk for type 1A diabetes. (PubMed id 16966600)1, 4 Aly T.A....Eisenbarth G.S. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    837. HLA genes in Southern Tunisians (Ghannouch area) and their relationship with other Mediterraneans. (PubMed id 16473309)1, 4 Hajjej A....Boukef K. (Eur J Med Genet 2006)
    838. HLA class II polymorphisms in Spanish melanoma patients: homozygosity for HLA-DQA1 locus can be a potential melanoma risk factor. (PubMed id 16433795)1, 4 Planelles D....Montoro J.A. (Br. J. Dermatol. 2006)
    839. Association of tumor necrosis factor alpha polymorphism, but not the shared epitope, with increased radiographic progression in a seropositive rheumatoid arthritis inception cohort. (PubMed id 16572445)1, 4 Khanna D....Tsao B.P. (Arthritis Rheum. 2006)
    840. Polymorphism of HLA class II genes in Miao and Yao nationalities of Southwest China. (PubMed id 16441488)1, 4 Liu Y....Xu A. (Tissue Antigens 2006)
    841. Analysis of HLA alleles polymorphism in Chinese patients with primary biliary cirrhosis. (PubMed id 16481299)1, 4 Liu H.Y....Zhong R.Q. (amp 2006)
    842. Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. (PubMed id 16905561)1, 4 Barcellos L.F....Oksenberg J.R. (Hum. Mol. Genet. 2006)
    843. Association of immune responses to mycobacterium tuberculosis peptide antigens with host genetic factors. (PubMed id 17153701)1, 4 Saad A.H....Zakaria Z. (J Egypt Soc Parasitol 2006)
    844. Comparative analysis of DR and DQ alleles occurrence in sarcoidosis and tuberculosis in the same ethnic group: preliminary study. (PubMed id 18038917)1, 4 Dubaniewicz A....Dubaniewicz A. (Sarcoidosis Vasc Diffuse Lung Dis 2006)
    845. The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan. (PubMed id 16352685)1, 4 Ikegami H....Ogihara T. (J. Clin. Endocrinol. Metab. 2006)
    846. The contribution of HLA class I and II alleles and haplotypes to the investigation of the evolutionary history of Tunisians. (PubMed id 16866885)1, 4 Hajjej A....Hmida S. (Tissue Antigens 2006)
    847. Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies. (PubMed id 16609350)1, 4 O'Hanlon T.P....Miller F.W. (Medicine (Baltimore) 2006)
    848. [Research on association between atherosclerotic brain infarction and human leukocyte antigen DR gene]. (PubMed id 16700999)1, 4 Zhang S.Y....Zhang X.Z. (Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2006)
    849. Human leukocyte antigen non-class II determinants for type 1 diabetes in the Finnish population. (PubMed id 17002902)1, 4 Gombos Z....Hermann R. (Hum. Immunol. 2006)
    850. HLA-DRB1, -DQB1 alleles in head and neck carcinoma patients. (PubMed id 16573562)1, 4 Koskinen W.J....Aaltonen L.M. (Tissue Antigens 2006)
    851. HLA-DRB1alleles and osteoarthritis in a group of patients living in Liguria-Italy. (PubMed id 16855521)1, 4 Rovetta G....Molfetta L. (Minerva Med. 2006)
    852. Genetic association of type 1 diabetes in an Azerbaijanian population: the HLA-DQ, -DRB1*04, the insulin gene, and CTLA4. (PubMed id 16629714)1, 4 Ahmedov G....Cinek O. (Pediatr Diabetes 2006)
    853. HSP70-hom gene single nucleotide (+2763 G/A and +2437 C/T) polymorphisms in sarcoidosis. (PubMed id 16611259)1, 4 Bogunia-Kubik K....Lange A. (Int. J. Immunogenet. 2006)
    854. HLA class II influences humoral autoimmunity in patients with type 2 autoimmune hepatitis. (PubMed id 17050030)1, 4 Djilali-Saiah I....Alvarez F. (J. Hepatol. 2006)
    855. Chronic periaortitis and HLA-DRB1*03: another clue to an autoimmune origin. (PubMed id 16463424)1, 4 Martorana D....Neri T.M. (Arthritis Rheum. 2006)
    856. Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study. (PubMed id 16879749)1, 4 Ogata T....Kuivaniemi H. (BMC Med. Genet. 2006)
    857. Association of the truncating splice site mutation in BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15. (PubMed id 16321988)1, 4 Traherne J.A....Trowsdale J. (Hum. Mol. Genet. 2006)
    858. Microsatellite typing for DRB1 alleles: application to the analysis of HLA associations with rheumatoid arthritis. (PubMed id 16855621)1, 4 Lee H.S....Gregersen P.K. (Genes Immun. 2006)
    859. Interaction of loci within the HLA region influences multiple sclerosis course in the Sardinian population. (PubMed id 16096810)1, 4 Marrosu M.G....Contu P. (J. Neurol. 2006)
    860. Investigation of the HLA-DRB1 locus in alopecia areata. (PubMed id 16935791)1, 4 Entz P....NAPthen M.M. (Eur J Dermatol 2006)
    861. HLA-DQA is associated with abdominal aortic aneurysms in the Belgian population. (PubMed id 17182961)1, 4 Tromp G....Kuivaniemi H. (Ann. N. Y. Acad. Sci. 2006)
    862. Earlier occurrence of severe alopecia areata in HLA-DRB1*11-positive patients. (PubMed id 16778420)1, 4 Marques Da Costa C....Stene J.J. (Dermatology (Basel) 2006)
    863. [Association of haplotype formed on HLA-DRB1 and HLA-DQA1 alleles with outcomes of hepatitis B virus infection]. (PubMed id 16883532)1, 4 Lu L.P....Li H. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006)
    864. Association of HLA DQ4-DR8 haplotype with papillary thyroid carcinomas. (PubMed id 16430717)1, 4 Porto T....Leite V. (Clin. Endocrinol. (Oxf) 2006)
    865. Smoking interacts with genetic risk factors in the development of rheumatoid arthritis among older Caucasian women. (PubMed id 16887863)1, 4 Criswell L.A....Seldin M.F. (Ann. Rheum. Dis. 2006)
    866. HLA class II gene polymorphism in Parsees and Zoroastrians of Iran. (PubMed id 16712649)1, 4 Farjadian S....Ghaderi A. (Int. J. Immunogenet. 2006)
    867. Extensive multiallelic analysis of the relationship between HLA-DRB1 and rheumatoid arthritis using a Bayesian partition model. (PubMed id 16826237)1, 4 Marotte H....Miossec P. (Genes Immun. 2006)
    868. HLA genes in Lamas Peruvian-Amazonian Amerindians. (PubMed id 16337001)1, 4 Moscoso J....Arnaiz-Villena A. (Mol. Immunol. 2006)
    869. Association of HLA-DR and -DQ genes with narcolepsy in Koreans: comparison with two control groups, randomly selected subjects and DRB1*1501-DQB1*0602--positive subjects. (PubMed id 17002906)1, 4 Roh E.Y....Jeong D.U. (Hum. Immunol. 2006)
    870. Studies on the human leukocyte antigens in patients with polycystic ovary syndrome in a Japanese population--possible susceptibility of HLA-A11 and -DRB1*0403 to patient population with polycystic ovary syndrome. (PubMed id 16533342)1, 4 Kaibe M....Tanaka K. (Am. J. Reprod. Immunol. 2006)
    871. Association of HLA class I and class II alleles with psoriasis vulgaris in Turkish population. Influence of type I and II psoriasis. (PubMed id 16532100)1, 4 Atasoy M....Aktas A. (Saudi Med J 2006)
    872. Polymorphisms of TNF microsatellite marker a and HLA-DR-DQ in diabetes mellitus-a study in 609 Swedish subjects. (PubMed id 16829307)1, 4 TAPrn C....Landin-Olsson M. (Hum. Immunol. 2006)
    873. The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis. (PubMed id 16572446)1, 4 van der Helm-van Mil A.H....de Vries R.R. (Arthritis Rheum. 2006)
    874. In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype. (PubMed id 16507114)1, 4 Chinoy H....Cooper R.G. (amp 2006)
    875. Molecular genetic studies on the compatibility of HLA class II alleles in patients with unexplained recurrent miscarriage in the Japanese population. (PubMed id 16122986)1, 4 Takakuwa K....Tanaka K. (Clin. Immunol. 2006)
    876. Studies of HLA associations in male and female patients with Guillain-BarrAc syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). (PubMed id 16935351)1, 4 McCombe P.A....Greer J.M. (J. Neuroimmunol. 2006)
    877. Interaction of HLA-DRB1 alleles with CTLA-4 in the predisposition to Graves' disease: the impact of DRB1*07. (PubMed id 16756466)1, 4 Kula D....Jarzab B. (Thyroid 2006)
    878. Genetic markers linked to rheumatoid arthritis are also strongly associated with articular manifestations in ulcerative colitis patients. (PubMed id 16720213)1, 4 NA_A+ez C....Martinez A. (Hum. Immunol. 2006)
    879. Alteration of the influences of HLA classes I and II alleles on the perinatal hepatitis B virus infection after immunoprophylaxis in Korean children. (PubMed id 16890179)1, 4 Kim J.H....Kim T.G. (Hepatol. Res. 2006)
    880. HLA class II allele frequencies in type 1A diabetes mellitus Slovak patients. (PubMed id 16796128)1, 4 Shawkatova I....Buc M. (Bratisl Lek Listy 2006)
    881. Value of the HLA-DRB1 shared epitope for predicting radiographic damage in rheumatoid arthritis depends on the individual patient risk profile. (PubMed id 16960929)1, 4 Janssens A.C....Criswell L.A. (J. Rheumatol. 2006)
    882. Correlation between HLA and pityriasis rosea susceptibility in Brazilian blacks. (PubMed id 16405603)1, 4 Miranda S.M....Filgueira A.L. (J Eur Acad Dermatol Venereol 2006)
    883. [Association of polymorphisms of human leucocyte antigen -DRB1 and -DQA1 allele with outcomes of hepatitis B virus infection in Han population of north China]. (PubMed id 16733891)1, 4 Lu L.P....Li H. (Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2006)
    884. HLA DRB1*15-DPB1*05 haplotype: a susceptible gene marker for isocyanate-induced occupational asthma? (PubMed id 16792590)1, 4 Kim S.H....Park H.S. (Allergy 2006)
    885. HLA-DRB1 genotyping in Italian migraine patients. (PubMed id 16356649)1, 4 Rainero I....Pinessi L. (Neurosci. Lett. 2006)
    886. No primary association of MICA polymorphism with systemic lupus erythematosus. (PubMed id 16537577)1, 4 SA!nchez E....GonzA!lez-Escribano M.F. (Rheumatology (Oxford) 2006)
    887. Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles. (PubMed id 16014670)1, 4 Linn-Rasker S.P....Huizinga T.W. (Ann. Rheum. Dis. 2006)
    888. Immunogenetic risk and protective factors for juvenile dermatomyositis in Caucasians. (PubMed id 17133612)1, 4 Mamyrova G....Rider L.G. (Arthritis Rheum. 2006)
    889. Intravenous synthetic peptide MBP8298 delayed disease progression in an HLA Class II-defined cohort of patients with progressive multiple sclerosis: results of a 24-month double-blind placebo-controlled clinical trial and 5 years of follow-up treatment. (PubMed id 16879301)1, 4 Warren K.G....Krantz M.J. (Eur. J. Neurol. 2006)
    890. HLA class II polymorphism: protective or risk factors to breast cancer in Tunisia? (PubMed id 16799707)1, 4 Baccar Harrath A....Ben Ammar Elgaaied A. (Pathol. Oncol. Res. 2006)
    891. Clinical significance of HLA DRB103-DRB104 in type 1 autoimmune hepatitis. (PubMed id 17105585)1, 4 Montano-Loza A.J....Czaja A.J. (Liver Int. 2006)
    892. Interleukin-12p40 gene (IL-12B) polymorphism and Type 1 diabetes mellitus in Japanese: possible role in subjects without having high-risk HLA haplotypes. (PubMed id 16005098)1, 4 Yang J.M....Ishibashi S. (Diabetes Res. Clin. Pract. 2006)
    893. Human leukocyte antigen and interleukin 2, 10 and 12p40 cytokine responses to measles: is there evidence of the HLA effect? (PubMed id 17234427)1, 4 Ovsyannikova I.G....Poland G.A. (Cytokine 2006)
    894. Carriage of DRB1*13 is associated with increased posttreatment IgE levels against Schistosoma mansoni antigens and lower long-term reinfection levels. (PubMed id 16709874)1, 4 Booth M....Dunne D.W. (J. Immunol. 2006)
    895. The prevalence of human leukocyte antigen (HLA) DR/DQ/DP alleles in Kuwaiti children with oligoarticular juvenile idiopathic arthritis. (PubMed id 15703957)1, 4 Alsaeid K....Ayoub E.M. (Rheumatol. Int. 2006)
    896. High-resolution molecular characterization of the HLA class I and class II in the Tarahumara Amerindian population. (PubMed id 16866883)1, 4 GarcA-a-Ortiz J.E....ArgA1ello J.R. (Tissue Antigens 2006)
    897. Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese. (PubMed id 16208405)1, 4 Tsuchiya N....Tokunaga K. (Genes Immun. 2006)
    898. Association of HLA-DRB1*13 with susceptibility to uveitis in juvenile idiopathic arthritis in two independent data sets. (PubMed id 16495319)1, 4 Zeggini E....Thomson W. (Rheumatology (Oxford) 2006)
    899. The relationship between HLA class II polymorphisms and somatic deletions in testicular B cell lymphomas of Dutch patients. (PubMed id 16720210)1, 4 Riemersma S.A....Kluin P.M. (Hum. Immunol. 2006)
    900. HLA-DRB1 alleles and cervical squamous cell carcinoma: experimental study and meta-analysis. (PubMed id 16720214)1, 4 Yang Y.C....Lin M. (Hum. Immunol. 2006)
    901. MHC2TA single nucleotide polymorphism and genetic risk for autoimmune adrenal insufficiency. (PubMed id 16849401)1, 4 Ghaderi M....Falorni A. (J. Clin. Endocrinol. Metab. 2006)
    902. Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine. (PubMed id 16453260)1, 4 Ovsyannikova I.G....Poland G.A. (J. Infect. Dis. 2006)
    903. Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis. (PubMed id 16846526)1, 4 Morgan A.W....Isaacs J.D. (amp 2006)
    904. No association between HLA-DRB1 alleles and susceptibility to advanced stage endometriosis in a Korean population. (PubMed id 16155070)1, 4 Whang D.H....Kim Y.B. (Hum. Reprod. 2006)
    905. Genetics of fulminant type 1 diabetes. (PubMed id 17130528)1, 4 Kawasaki E. and Eguchi K. (Ann. N. Y. Acad. Sci. 2006)
    906. A second component of HLA-linked susceptibility to type 1 diabetes maps to class I region. (PubMed id 17130566)1, 4 Kawabata Y....Ogihara T. (Ann. N. Y. Acad. Sci. 2006)
    907. Association of the PTPN22/LYP gene with type 1 diabetes. (PubMed id 17054449)1, 4 Steck A.K....She J.X. (Pediatr Diabetes 2006)
    908. Helicobacter pylori infection and autoimmune thyroid disease in young patients: the disadvantage of carrying the human leukocyte antigen-DRB1*0301 allele. (PubMed id 16263823)1, 4 Larizza D....Solcia E. (J. Clin. Endocrinol. Metab. 2006)
    909. Genetic susceptibility to rheumatic heart disease and streptococcal pharyngitis: association with HLA-DR alleles. (PubMed id 17026463)1, 4 HaydardedeoA9lu F.E....DA1zgA1n N. (Tissue Antigens 2006)
    910. HLA-DRB genotype and specific IgE responses in patients with allergies to penicillins. (PubMed id 16584643)1, 4 Yang J....Gao N. (Chin. Med. J. 2006)
    911. Lack of association of HLA class II alleles with peanut allergy. (PubMed id 16802776)1, 4 Shreffler W.G....Sicherer S.H. (amp 2006)
    912. HLA class I and class II frequencies in patients with cutaneous malignant melanoma from southeastern Spain: the role of HLA-C in disease prognosis. (PubMed id 16365741)1, 4 Campillo J.A....Alvarez-LA^pez M.R. (Immunogenetics 2006)
    913. Association of tumour necrosis factor a, b and c microsatellite polymorphisms with clinical disease activity and induction of remission in early rheumatoid arthritis. (PubMed id 17207378)1, 4 Laivoranta-Nyman S....Ilonen J. (Clin. Exp. Rheumatol. 2006)
    914. A new classification of HLA-DRB1 alleles differentiates predisposing and protective alleles for rheumatoid arthritis structural severity. (PubMed id 16447236)1, 4 Gourraud P.A....Constantin A. (Arthritis Rheum. 2006)
    915. [Analysis of HLA-DRB1 allele polymorphism in the Fujian Han nationality population of China]. (PubMed id 16604510)1, 4 Wang Q.H....Tan J.M. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006)
    916. HLA alleles and haplotypes in French North African immigrants. (PubMed id 16829309)1, 4 PAcdron B....Sterkers G. (Hum. Immunol. 2006)
    917. Association of human leukocyte antigen polymorphism with hepatitis B virus infection and genotypes. (PubMed id 17186951)1, 4 Zhang S.Y....Jin X. (Jpn. J. Infect. Dis. 2006)
    918. Possible interaction between HLA-DRbeta1 and thyroglobulin variants in Graves' disease. (PubMed id 16646680)1, 4 Hodge S.E....Tomer Y. (Thyroid 2006)
    919. Associations between HLA class II alleles and type 1 diabetes mellitus in the Slovak population. (PubMed id 16964961)1, 4 Buc M....Petrek M. (Endocr Regul 2006)
    920. Human leukocyte antigen DRB1*04 is associated with rheumatoid arthritis in Kuwaiti patients. (PubMed id 16226480)1, 4 Alsaeid K....Haider M.Z. (Joint Bone Spine 2006)
    921. Association of selective HLA class II susceptibility-conferring and protective haplotypes with type 2 diabetes in patients from Bahrain and Lebanon. (PubMed id 16988007)1, 4 Almawi W.Y....Irani-Hakime N. (Clin. Vaccine Immunol. 2006)
    922. Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India. (PubMed id 16923796)1, 4 Tosh K....Pitchappan R. (Hum. Mol. Genet. 2006)
    923. TNFa-e microsatellite, HLA-DRB1 and -DQB1 alleles and haplotypes in Brazilian patients presenting recently diagnosed type 1 diabetes mellitus. (PubMed id 17130569)1, 4 Rassi D.M....Donadi E.A. (Ann. N. Y. Acad. Sci. 2006)
    924. Genetic analysis of HLA, NA and HPA typing in type 2 diabetes and ASO. (PubMed id 16611256)1, 4 Nomura S....Fukuhara S. (Int. J. Immunogenet. 2006)
    925. The role of HLA molecules in susceptibility to chronic rheumatic heart disease. (PubMed id 16426242)1, 4 Kudat H....Guven O. (Int. J. Immunogenet. 2006)
    926. An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibility. (PubMed id 16142711)1, 4 van der Helm-van Mil A.H....Toes R.E. (Arthritis Rheum. 2005)
    927. Human leukocyte antigen class II alleles in Caucasian women with primary biliary cirrhosis. (PubMed id 15713222)1, 4 Mullarkey M.E....Nelson J.L. (Tissue Antigens 2005)
    928. Human leukocyte antigen and cytokine gene variants as predictors of recurrent Chlamydia trachomatis infection in high-risk adolescents. (PubMed id 15747244)1, 4 Wang C....Kaslow R.A. (J. Infect. Dis. 2005)
    929. Sensitivity to bee venom antigen phospholipase A2: association with specific HLA class I and class II alleles and haplotypes in beekeepers and allergic patients. (PubMed id 16112029)1, 4 SA!nchez-Velasco P....Leyva-CobiA!n F. (Hum. Immunol. 2005)
    930. Association between pemphigus vulgaris and human leukocyte antigen in Han nation of northeast China. (PubMed id 16261886)1, 4 Geng L....Chen H.D. (Chin. Med. Sci. J. 2005)
    931. Prevalence of HLA-DRB1 genotype and altered Fas/Fas ligand expression in adrenocortical carcinoma. (PubMed id 15585555)1, 4 WolkersdAPrfer G.W....Bornstein S.R. (J. Clin. Endocrinol. Metab. 2005)
    932. Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients. (PubMed id 16005527)1, 4 Lorentzen A.R....Harbo H.F. (J. Neuroimmunol. 2005)
    933. HLA-DR,DQ and APOE genotypes and gender influence in Sardinian primary progressive MS. (PubMed id 15699400)1, 4 Cocco E....Marrosu M.G. (Neurology 2005)
    934. Major histocompatibility complex class II (HLA-DRB and -DQB) allele frequencies in Botswana: association with human immunodeficiency virus type 1 infection. (PubMed id 16148166)1, 4 Ndung'u T....Essex M. (Clin. Diagn. Lab. Immunol. 2005)
    935. CT60 single nucleotide polymorphisms of the cytotoxic T-lymphocyte-associated antigen-4 gene region is associated with Graves' disease in an Italian population. (PubMed id 15785242)1, 4 Petrone A....Buzzetti R. (Thyroid 2005)
    936. Antigen presentation of the immunodominant T-cell epitope of the major mugwort pollen allergen, Art v 1, is associated with the expression of HLA-DRB1 *01. (PubMed id 15696102)1, 4 Jahn-Schmid B....Ebner C. (J. Allergy Clin. Immunol. 2005)
    937. Human leukocyte antigens in Japanese patients with biliary atresia: retrospective analysis of patients who underwent living donor liver transplantation. (PubMed id 15784468)1, 4 Yuasa T....Maekawa T. (Hum. Immunol. 2005)
    938. Influence of HLA-DR genes on the production of rheumatoid arthritis-specific autoantibodies to citrullinated fibrinogen. (PubMed id 16255019)1, 4 Auger I....Roudier J. (Arthritis Rheum. 2005)
    939. Major histocompatibility complex and alveolar epithelial apoptosis in idiopathic pulmonary fibrosis. (PubMed id 16133177)1, 4 FalfA!n-Valencia R....Selman M. (Hum. Genet. 2005)
    940. MHC microsatellite diversity and linkage disequilibrium among common HLA-A, HLA-B, DRB1 haplotypes: implications for unrelated donor hematopoietic transplantation and disease association studies. (PubMed id 16029431)1, 4 Malkki M....Petersdorf E. (Tissue Antigens 2005)
    941. Residual insulin secretion at diagnosis of type 1 diabetes is independently associated with both, age of onset and HLA genotype. (PubMed id 15786423)1, 4 Petrone A....Buzzetti R. (Diabetes Metab. Res. Rev. 2005)
    942. Association of HLA-DRB1, DQB1 alleles with chronic urticaria. (PubMed id 16201295)1, 4 Chen J....Xiong P. (J. Huazhong Univ. Sci. Technol. Med. Sci. 2005)
    943. Evidence for negative association of the chemokine receptor CCR5 d32 polymorphism with rheumatoid arthritis. (PubMed id 15331395)1, 4 Pokorny V....McLean L. (Ann. Rheum. Dis. 2005)
    944. The DR4-DQ8 haplotype and a specific T cell receptor Vbeta T cell subset are associated with absence of allergy to Can f 1. (PubMed id 15969672)1, 4 Kinnunen T....Virtanen T. (Clin. Exp. Allergy 2005)
    945. Association between human leukocyte antigen class II alleles and genotype of Borrelia burgdorferi in patients with early lyme disease. (PubMed id 16267776)1, 4 Wormser G.P....Klempner M. (J. Infect. Dis. 2005)
    946. [HLA-DRB1 alleles and rheumatoid arthritis in northern Italy: lack of correlation with disease severity and extra-articular manifestations]. (PubMed id 15929613)1, 4 Beri R....Lunardi C. (Recenti Prog Med 2005)
    947. HLA allelic variants encoding DR11 in diffuse and limited systemic sclerosis in Caucasian women. (PubMed id 15572392)1, 4 LoubiA"re L.S....Nelson J.L. (Rheumatology (Oxford) 2005)
    948. Interleukin 18 and sICAM-1 serum levels in families with type 1 diabetes mellitus. (PubMed id 16358956)1, 4 MiroA8czuk K....GA^rska M. (Rocz. Akad. Med. Bialymst. 2005)
    949. A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis. (PubMed id 16186814)1, 4 Lincoln M.R....Hudson T.J. (Nat. Genet. 2005)
    950. [Analysis of HLA alleles polymorphism in Chinese patients with primary biliary cirrhosis]. (PubMed id 15975271)1, 4 Liu H.Y....Zhong R.Q. (Zhonghua Gan Zang Bing Za Zhi 2005)
    951. Association of HLA-DR and -DQ genes with Graves disease in Koreans. (PubMed id 15993720)1, 4 Park M.H....Cho B.Y. (Hum. Immunol. 2005)
    952. Immunogenetics of primary SjAPgren's syndrome in Colombians. (PubMed id 15846589)1, 4 Anaya J.M....Correa P.A. (Semin. Arthritis Rheum. 2005)
    953. Anti-caspase-8 autoantibody response in silicosis patients is associated with HLA-DRB1, DQB1 and DPB1 alleles. (PubMed id 15703453)1, 4 Ueki A....Kusaka M. (J Occup Health 2005)
    954. A case-control study to examine HLA haplotype associations in patients with posttreatment chronic Lyme disease. (PubMed id 16107953)1, 4 Klempner M.S....Schmid C. (J. Infect. Dis. 2005)
    955. [Relationship between pneumoconiosis and the polymorphisms of HLA-DRB1*, DQB1* genes]. (PubMed id 16188098)1, 4 Fan X.Y....Ma Q.K. (Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2005)
    956. Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiforme. (PubMed id 16103458)1, 4 Tang J....Cobbs C.S. (amp 2005)
    957. Polymorphism of human leukocyte antigen-DRB1, -DQB1, and -DPB1 genes of Shandong Han population in China. (PubMed id 15982255)1, 4 Zhou L....Xu A. (Tissue Antigens 2005)
    958. The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria. (PubMed id 15784113)1, 4 Kim S.H....Park H.S. (Clin. Exp. Allergy 2005)
    959. HLA class II alleles are not a general susceptibility factor in Guillain-BarrAc syndrome. (PubMed id 15642902)1, 4 Geleijns K....van Doorn P.A. (Neurology 2005)
    960. Susceptibility alleles and haplotypes of human leukocyte antigen DRB1, DQA1, and DQB1 in autoimmune polyglandular syndrome type III in Japanese population. (PubMed id 16254435)1, 4 Hashimoto K....Nakamura T. (Horm. Res. 2005)
    961. Development of a new HLA-DRB real-time PCR typing method. (PubMed id 15620466)1, 4 Casamitjana N....Palou E. (Hum. Immunol. 2005)
    962. Association of SLC11A1 (NRAMP1) with persistent oligoarticular and polyarticular rheumatoid factor-negative juvenile idiopathic arthritis in Finnish patients: haplotype analysis in Finnish families. (PubMed id 15641099)1, 4 Runstadler J.A....Seldin M.F. (Arthritis Rheum. 2005)
    963. [Study on the correlation between acute lymphoblastic leukemia and HLA genes in southern China Han population]. (PubMed id 15854278)1, 4 Gao S.Q....Wu G.G. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2005)
    964. Estimation of diabetes risk in Brazilian population by typing for polymorphisms in HLA-DR-DQ, INS and CTLA-4 genes. (PubMed id 16276008)1, 4 Hauache O.M....Ilonen J. (Dis. Markers 2005)
    965. New strategies for efficient typing of HLA class-II loci DQB1 and DRB1 by using Pyrosequencing. (PubMed id 15663743)1, 4 Entz P....Nagy M. (Tissue Antigens 2005)
    966. The clinical and genetic associations of anti-cyclic citrullinated peptide antibodies in psoriatic arthritis. (PubMed id 15901902)1, 4 Korendowych E....McHugh N. (Rheumatology (Oxford) 2005)
    967. HLA alleles in frequently relapsing steroid-dependent and -resistant nephrotic syndrome in Egyptian children. (PubMed id 15625617)1, 4 Bakr A.M....Al-Husseni F. (Pediatr. Nephrol. 2005)
    968. Lymphoid tyrosine phosphatase (PTPN22/LYP) variant and Graves' disease in a Polish population: association and gene dose-dependent correlation with age of onset. (PubMed id 15943829)1, 4 SkA^rka A....Ploski R. (Clin. Endocrinol. (Oxf) 2005)
    969. Association of HLA class I and class II polymorphisms with age-related macular degeneration. (PubMed id 15851575)1, 4 Goverdhan S.V....Lotery A.J. (amp 2005)
    970. Relationship between HLA-DR, HLA-DQ alleles and MEFV gene mutations in familial Mediterranean fever (FMF) patients. (PubMed id 16245224)1, 4 Kinikli G....TokgAPz G. (Turk J Gastroenterol 2005)
    971. Population frequency of HLA haplotypes contributes to the prevalence difference of multiple sclerosis in Ireland. (PubMed id 16158194)1, 4 McGuigan C....Hutchinson M. (J. Neurol. 2005)
    972. Does genotype mask the relationship between psychological factors and immune function? (PubMed id 15664787)1, 4 Smith A....Lloyd A. (Brain Behav. Immun. 2005)
    973. Association of clinical features with HLA in chronic pulmonary thromboembolism. (PubMed id 15640334)1, 4 Tanabe N....Kuriyama T. (Eur. Respir. J. 2005)
    974. Contribution of selective HLA-DRB1/DQB1 alleles and haplotypes to the genetic susceptibility of type 1 diabetes among Lebanese and Bahraini Arabs. (PubMed id 15985473)1, 4 Al-Jenaidi F.A....Almawi W.Y. (J. Clin. Endocrinol. Metab. 2005)
    975. Linkage disequilibrium between human leukocyte antigen (HLA) class II and HLA-G--possible implications for human reproduction and autoimmune disease. (PubMed id 15993714)1, 4 Hviid T.V. and Christiansen O.B. (Hum. Immunol. 2005)
    976. HLA-DRB1 alleles and Jk(a) immunization. (PubMed id 15934994)1, 4 Reviron D....Chiaroni J. (Transfusion 2005)
    977. [Microarray DNA chip in analyzing the association between HLA-DRB and advanced hepatosplenic schistosomiasis]. (PubMed id 16566202)1, 4 Cheng Y.L....Wu H. (amp 2005)
    978. Prevalence of DRB1*01 and DRB1*04 alleles in a group of patients with rheumatoid arthritis living in Liguria. (PubMed id 16366416)1, 4 Rovetta G....Garbarino L. (Int J Clin Pharmacol Res 2005)
    979. Optic neuritis, multiple sclerosis and human leukocyte antigen: results of a 4-year follow-up study. (PubMed id 15613143)1, 4 Amirzargar A.A....Nikbin B. (Eur. J. Neurol. 2005)
    980. [Extent and location of lesions in aorta and its main branches in patients with nonspecific aortoarteritis with various genotypes in the region of major histocompatibility complex]. (PubMed id 16007032)1, 4 Chikhladze N.M....Chazova I.E. (Kardiologiia 2005)
    981. Association of the HLA region with multiple sclerosis as confirmed by a genome screen using &gt;10,000 SNPs on DNA chips. (PubMed id 15770496)1, 4 GAPdde R....Epplen J.T. (J. Mol. Med. 2005)
    982. Systemic lupus erythematosus and the extended major histocompatibility complex--evidence for several predisposing loci. (PubMed id 16174649)1, 4 Smerdel-Ramoya A....Lie B.A. (Rheumatology (Oxford) 2005)
    983. Association between psoriasis vulgaris and MHC-DRB, -DQB genes as a contribution to disease diagnosis. (PubMed id 15908298)1, 4 Cardoso C.B....Kraemer M.H. (Eur J Dermatol 2005)
    984. Analysis of B- and T-cell clonality and HLA class II alleles in patients with idiopathic thrombocytopenic purpura: correlation with Helicobacter pylori infection and response to eradication treatment. (PubMed id 16011982)1, 4 Veneri D....Franchini M. (Platelets 2005)
    985. Allelic and haplotypic diversity of HLA-A, -B, -C, -DRB1, and -DQB1 genes in the Korean population. (PubMed id 15853898)1, 4 Lee K.W....Yang S.Y. (Tissue Antigens 2005)
    986. Predisposition to nevirapine hypersensitivity associated with HLA-DRB1*0101 and abrogated by low CD4 T-cell counts. (PubMed id 15627041)1, 4 Martin A.M....Mallal S. (AIDS 2005)
    987. Genetic interaction among three genomic regions creates distinct contributions to early- and late-onset type 1 diabetes mellitus. (PubMed id 16390390)1, 4 Felner E.I....White P.C. (Pediatr Diabetes 2005)
    988. Association of CD40 gene polymorphism (C-1T) with susceptibility and phenotype of Graves' disease. (PubMed id 16279844)1, 4 Kurylowicz A....Bednarczuk T. (Thyroid 2005)
    989. Autoimmunity against neurofilament protein and its possible association with HLA-DRB1*1502 allele in glaucoma. (PubMed id 16005081)1, 4 Yano T....Tanihara H. (Immunol. Lett. 2005)
    990. The association between HLA DR, DQ antigens, and vulval lichen sclerosus in the UK: HLA DRB112 and its associated DRB112/DQB10301/04/09/010 haplotype confers susceptibility to vulval lichen sclerosus, and HLA DRB10301/04 and its associated DRB10301/04/DQB10201/02/03 haplotype protects from vulval lichen sclerosus. (PubMed id 16297186)1, 4 Gao X.H....Wojnarowska F. (J. Invest. Dermatol. 2005)
    991. [Correlation between the polymorphism of HLA-A, -B, and -DRB1 alleles and susceptibility to leukemia]. (PubMed id 16143070)1, 4 Zhou L.X. and Zhao L. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2005)
    992. Analysis of HLA class I and class II gene polymorphisms in Japanese patients with human T-cell lymphotropic virus type 1-associated uveitis. (PubMed id 16019679)1, 4 Kaminagayoshi T....Sakamoto T. (Ocul. Immunol. Inflamm. 2005)
    993. Susceptible and protective human leukocyte antigen class II alleles and haplotypes in bahraini type 2 (non-insulin-dependent) diabetes mellitus patients. (PubMed id 15643010)1, 4 Motala A.A....Almawi W.Y. (Clin. Diagn. Lab. Immunol. 2005)
    994. Impact of HLA class I high-resolution mismatches on chronic graft-versus-host disease and survival of patients given hematopoietic stem cell grafts from unrelated donors. (PubMed id 15531903)1, 4 Greinix H.T....Fischer G.F. (Bone Marrow Transplant. 2005)
    995. Human leukocyte antigen class II DQB1*0301, DRB1*1101 alleles and spontaneous clearance of hepatitis C virus infection: a meta-analysis. (PubMed id 16437632)1, 4 Hong X....Wu G.L. (World J. Gastroenterol. 2005)
    996. HLA polymorphisms are associated with Helicobacter pylori infected gastric cancer in a high risk population, China. (PubMed id 15650879)1, 4 Li Z....Ke Y. (Immunogenetics 2005)
    997. Clinical course of sarcoidosis in dependence on HLA-DRB1 allele frequencies, inflammatory markers, and the presence of M. tuberculosis DNA fragments. (PubMed id 15881283)1, 4 Grosser M....Baretton G. (Sarcoidosis Vasc Diffuse Lung Dis 2005)
    998. Human leukocyte antigen-DQB1 and -DRB1 associations in patients with idiopathic sudden sensorineural hearing loss from a defined population of Northwest Spain. (PubMed id 16303674)1, 4 Amor-Dorado J.C....Gonzalez-Gay M.A. (Acta Otolaryngol. 2005)
    999. Maternal HLA class II compatibility in men with systemic lupus erythematosus. (PubMed id 16142706)1, 4 Stevens A.M....Nelson J.L. (Arthritis Rheum. 2005)
    1000. Function associated transforming growth factor-beta gene polymorphism in chronic beryllium disease. (PubMed id 15750822)1, 4 Gaede K.I....MA1ller-Quernheim J. (J. Mol. Med. 2005)
    1001. Frequency of DRB1-DQB1 two-locus haplotypes in tuberculosis: preliminary report. (PubMed id 15958261)1, 4 Dubaniewicz A....Szczerkowska Z. (Tuberculosis (Edinb) 2005)
    1002. Retrovirus-like long-terminal repeat DQ-LTR13 and genetic susceptibility to type 1 diabetes and autoimmune Addison's disease. (PubMed id 15734871)1, 4 Gambelunghe G.... . (Diabetes 2005)
    1003. [Studies on the association of human leukocyte antigen class II alleles with advanced hepatosplenic schistosomiasis japonica]. (PubMed id 16042197)1, 4 Zhang J.H....Long X.C. (amp 2005)
    1004. Influence of HLA-DRB1 alleles and HBV genotypes on interferon-alpha therapy for chronic hepatitis B. (PubMed id 16094724)1, 4 Chu R.H....Shao L.H. (World J. Gastroenterol. 2005)
    1005. The presence of glutamic acid at positions 71 or 74 in pocket 4 of the HLA-DRbeta1 chain is associated with the clinical course of multiple sclerosis. (PubMed id 15834022)1, 4 Greer J.M. and Pender M.P. (J. Neurol. Neurosurg. Psychiatr. 2005)
    1006. HLA class I and II polymorphisms in Azores show different settlements in Oriental and Central islands. (PubMed id 16101833)1, 4 SpA-nola H....Bruges-Armas J. (Tissue Antigens 2005)
    1007. An investigation of NOS2A promoter polymorphisms in Australian multiple sclerosis patients. (PubMed id 15856071)1, 4 Bugeja M.J....Stewart G.J. (Eur. J. Hum. Genet. 2005)
    1008. Association between human leukocytes antigen alleles and chronic hepatitis C virus infection in the Korean population. (PubMed id 16343061)1, 4 Yoon S.K....Kim T.G. (Liver Int. 2005)
    1009. [Study on correlation between histocompatibility leukocyte antigen class II gene and gestational diabetes mellitus]. (PubMed id 16277897)1, 4 Zhao M.L....Qi W.J. (Zhonghua Fu Chan Ke Za Zhi 2005)
    1010. Human leukocyte antigen class II alleles and rubella-specific humoral and cell-mediated immunity following measles-mumps-rubella-II vaccination. (PubMed id 15655774)1, 4 Ovsyannikova I.G....Poland G.A. (J. Infect. Dis. 2005)
    1011. Genetic contribution of the tumour necrosis factor (TNF) B + 252*2/2 genotype, but not the TNFa,b microsatellite alleles, to systemic lupus erythematosus in Japanese patients. (PubMed id 15932622)1, 4 Takeuchi F....Tanimoto K. (Int. J. Immunogenet. 2005)
    1012. Predisposing HLA-DQ2 and HLA-DQ8 haplotypes of coeliac disease and associated enteropathy in microscopic colitis. (PubMed id 16292086)1, 4 FernA!ndez-BaA+ares F....Viver J.M. (amp 2005)
    1013. Sarcoidosis is associated with a truncating splice site mutation in BTNL2. (PubMed id 15735647)1, 4 Valentonyte R....Schreiber S. (Nat. Genet. 2005)
    1014. Association of chronic fatigue syndrome with human leucocyte antigen class II alleles. (PubMed id 16049290)1, 4 Smith J....Mattey D.L. (J. Clin. Pathol. 2005)
    1015. Contribution of MHC class I chain-related A (MICA) gene polymorphism to genetic susceptibility for systemic lupus erythematosus. (PubMed id 15522921)1, 4 Gambelunghe G....Falorni A. (Rheumatology (Oxford) 2005)
    1016. Association of extrahepatic manifestations with HLA class II alleles and with virus genotype in HCV infected patients. (PubMed id 16180280)1, 4 Sebastiani G.D....Galeazzi M. (J. Biol. Regul. Homeost. Agents 2005)
    1017. Identification of HLA-DQalpha and -DRbeta residues associated with susceptibility and protection to epithelial ovarian cancer. (PubMed id 15935893)1, 4 Monos D.S....Platsoucas C.D. (Hum. Immunol. 2005)
    1018. HLA class II involvement in HIV-associated Toxoplasmic encephalitis development. (PubMed id 15885635)1, 4 Habegger de Sorrentino A....SalomA^n H. (Clin. Immunol. 2005)
    1019. Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1 and -DQA1 allelic profiles and motifs define clinicopathologic groups in caucasians. (PubMed id 16267409)1, 4 O'Hanlon T.P....Miller F.W. (Medicine (Baltimore) 2005)
    1020. D6S265*15 marks a DRB1*15, DQB1*0602 haplotype associated with attenuated protection from type 1 diabetes mellitus. (PubMed id 16320082)1, 4 Valdes A.M.... . (Diabetologia 2005)
    1021. Does a central MHC gene in linkage disequilibrium with HLA-DRB1*0401 affect susceptibility to type 1 diabetes? (PubMed id 15858601)1, 4 Windsor L....Price P. (Genes Immun. 2005)
    1022. Glutamic acid decarboxylase autoantibody prevalence and association with HLA genotype in patients with younger-onset type 1 diabetes and proliferative diabetic retinopathy. (PubMed id 16157380)1, 4 Mimura T....Hori S. (Ophthalmology 2005)
    1023. A novel HLA allele, DRB1*1609, identified in the Chinese Han population*. (PubMed id 16101839)1, 2 Miao K.R....Kukuruga D. (Tissue Antigens 2005)
    1024. HLA antigens and juvenile onset spondyloarthritides: negative association with non-B27 alleles. (PubMed id 16173256)1, 4 Silva-RamA-rez B....Burgos-Vargas R. (Clin. Exp. Rheumatol. 2005)
    1025. The Fc gammaRIIa polymorphism R/H131, autoantibodies against the platelet receptors GPIb alpha and Fc gammaRIIa and a risk for thromboembolism in lupus anticoagulant patients. (PubMed id 15735807)1, 4 Schallmoser K....Panzer S. (Thromb. Haemost. 2005)
    1026. Severe pulmonary sarcoidosis is strongly associated with the haplotype HLA-DQB1*0602-DRB1*150101. (PubMed id 16112030)1, 4 Voorter C.E....van den Berg-Loonen E.M. (Hum. Immunol. 2005)
    1027. Susceptibility to ovarian endometriosis in Polish population is not associated with HLA-DRB1 alleles. (PubMed id 15665016)1, 4 Roszkowski P.I....Malejczyk J. (Hum. Reprod. 2005)
    1028. The genetic contribution of the TNFa11 microsatellite allele and the TNFb + 252*2 allele in Japanese RA. (PubMed id 16095118)1, 4 Takeuchi F....Nakano K. (Clin. Exp. Rheumatol. 2005)
    1029. Human leukocyte antigen class I and II haplotypes and risk of cervical cancer. (PubMed id 16185329)1, 4 Carreon J.D....Wang S.S. (Tissue Antigens 2005)
    1030. HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. (PubMed id 15743917)1, 4 Hung S.I....Chen Y.T. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    1031. HLA-DRB1 alleles may influence disease phenotype in patients with inflammatory bowel disease: a critical reappraisal with review of the literature. (PubMed id 15690658)1, 4 Annese V....Andriulli A. (Dis. Colon Rectum 2005)
    1032. Relationship of human leukocyte antigen class II genes with the susceptibility to hepatitis B virus infection and the response to interferon in HBV-infected patients. (PubMed id 16237774)1, 4 Han Y.N....Zhu W. (World J. Gastroenterol. 2005)
    1033. Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles. (PubMed id 16320316)1, 4 Irigoyen P....Gregersen P.K. (Arthritis Rheum. 2005)
    1034. DRB1-TNF-alpha-TNF-beta haplotype is strongly associated with severe aortoiliac occlusive disease, a clinical form of atherosclerosis. (PubMed id 16386648)1, 4 Mas A....MartA-nez A. (Hum. Immunol. 2005)
    1035. Slowly progressing form of type 1 diabetes mellitus in children: genetic analysis compared with other forms of diabetes mellitus in Japanese children. (PubMed id 16390391)1, 4 Ohtsu S....Matsuura N. (Pediatr Diabetes 2005)
    1036. Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis. (PubMed id 16200610)1, 4 Verpoort K.N....Toes R.E. (Arthritis Rheum. 2005)
    1037. Association between alopecia areata and HLA Class I and II in Turkey. (PubMed id 16361713)1, 4 Aliagaoglu C....Aktas A. (J. Dermatol. 2005)
    1038. HLA class II allele control of HPV load in carcinoma in situ of the cervix uteri. (PubMed id 15906352)1, 4 Beskow A.H....Gyllensten U.B. (Int. J. Cancer 2005)
    1039. Association of HLA-DR and HLA-DQ genes with susceptibility to pulmonary tuberculosis in Koreans: preliminary evidence of associations with drug resistance, disease severity, and disease recurrence. (PubMed id 16386650)1, 4 Kim H.S....Shim Y.S. (Hum. Immunol. 2005)
    1040. Genetic analysis of the HLA region of Japanese patients with type 1 autoimmune hepatitis. (PubMed id 15763345)1, 4 Yoshizawa K....Kiyosawa K. (J. Hepatol. 2005)
    1041. HLA class II alleles and measles virus-specific cytokine immune response following two doses of measles vaccine. (PubMed id 15712014)1, 4 Ovsyannikova I.G....Poland G.A. (Immunogenetics 2005)
    1042. HLA class II DPB1, DQA1, DQB1, and DRB1 genotypic associations with occupational allergic cough to Bunashimeji mushroom. (PubMed id 15853900)1, 4 Suzuki K....Sato N. (Tissue Antigens 2005)
    1043. The relation between HLA-DRB1 alleles and the outcome of therapy in children with idiopathic thrombocytopenic purpura. (PubMed id 17977208)1, 4 El Neanaey W.A....Ahmed M.E. (Egypt J Immunol 2005)
    1044. Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis. (PubMed id 16014635)1, 4 Kuroki K....Tokunaga K. (Hum. Mol. Genet. 2005)
    1045. Extended haplotype analysis reveals an association of TNF polymorphisms with susceptibility to systemic lupus erythematosus beyond HLA-DR3. (PubMed id 16095006)1, 4 Schotte H....SchlA1ter B. (Scand. J. Rheumatol. 2005)
    1046. Hepatitis C virus genotypes, HLA-DRB alleles and their response to interferon-alpha and ribavirin in patients with chronic hepatitis C. (PubMed id 15730926)1, 4 Jiao J. and Wang J.B. (amp 2005)
    1047. A recombined haplotype in the major histocompatibility region contains a cluster of genes conferring high susceptibility to ulcerative colitis in the Spanish population. (PubMed id 16116311)1, 4 FernA!ndez L....MartA-nez A. (Inflamm. Bowel Dis. 2005)
    1048. The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity. (PubMed id 16025255)1, 4 Hermann R....Ilonen J. (Diabetologia 2005)
    1049. HLA-DRB1 and -DQB1 alleles and gene polymorphisms of selected cytokines in systemic lupus erythematosus. (PubMed id 15449022)1, 4 Hrycek A....SzkrA^bka W. (Rheumatol. Int. 2005)
    1050. HLA alleles and risk of cervical intraepithelial neoplasia among southwestern American Indian women. (PubMed id 16386646)