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Aliases for HLA-DRB1 Gene

Aliases for HLA-DRB1 Gene

  • Major Histocompatibility Complex, Class II, DR Beta 1 2 3
  • DW2.2/DR2.2 3 4
  • DRw10 3 4
  • SS1 3 6
  • HLA Class II Histocompatibility Antigen, DR-1 Beta Chain 3
  • MHC Class II HLA-DR-Beta Cell Surface Glycoprotein 3
  • MHC Class II HLA-DR Beta 1 Chain 3
  • Human Leucocyte Antigen DRB1 3
  • MHC Class II Antigen DRB1*10 4
  • MHC Class II Antigen DRB1*11 4
  • MHC Class II Antigen DRB1*12 4
  • MHC Class II Antigen DRB1*13 4
  • MHC Class II Antigen DRB1*14 4
  • MHC Class II Antigen DRB1*15 4
  • MHC Class II Antigen DRB1*16 4
  • MHC Class II HLA-DRw10-Beta 3
  • MHC Class II Antigen DRB1*1 4
  • MHC Class II Antigen DRB1*3 4
  • MHC Class II Antigen DRB1*4 4
  • MHC Class II Antigen DRB1*7 4
  • MHC Class II Antigen DRB1*8 4
  • MHC Class II Antigen DRB1*9 4
  • Lymphocyte Antigen DRB1 3
  • MHC Class II Antigen 3
  • Clone P2-Beta-3 4
  • HLA-DR1B 3
  • HLA-DRB2 4
  • HLA-DRB 3
  • DR-12 4
  • DR-13 4
  • DR-14 4
  • DR-16 4
  • DRw11 4
  • DRB1 3
  • DR-1 4
  • DR-4 4
  • DR-5 4
  • DR-7 4
  • DR-8 4
  • DR-9 4
  • DR12 4
  • DR13 4
  • DR14 4
  • DR16 4
  • DRw8 4
  • DR5 4
  • DR4 4
  • DR1 4
  • DR7 4
  • DR8 4
  • DR9 4

External Ids for HLA-DRB1 Gene

Previous Symbols for HLA-DRB1 Gene

  • HLA-DR1B

Summaries for HLA-DRB1 Gene

Entrez Gene Summary for HLA-DRB1 Gene

  • HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-DRB1 Gene

HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1) is a Protein Coding gene. Diseases associated with HLA-DRB1 include sarcoidosis 1 and sine scleroderma. Among its related pathways are Class I MHC mediated antigen processing and presentation and GPCR Pathway. GO annotations related to this gene include peptide antigen binding and MHC class II receptor activity. An important paralog of this gene is HLA-DMA.

  • Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading

  • Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading

Gene Wiki entry for HLA-DRB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-DRB1 Gene

Genomics for HLA-DRB1 Gene

Genomic Location for HLA-DRB1 Gene

Start:
32,552,990 bp from pter
End:
32,589,848 bp from pter
Size:
36,859 bases
Orientation:
Minus strand

Genomic View for HLA-DRB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HLA-DRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for HLA-DRB1 Gene

Proteins for HLA-DRB1 Gene

  • Protein details for HLA-DRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01911-2B1F_HUMAN
    Recommended name:
    HLA class II histocompatibility antigen, DRB1-15 beta chain
    Protein Accession:
    P01911
    Secondary Accessions:
    • Q29790
    • Q29975
    • Q30142
    • Q30166
    • Q32MY7
    • Q56FN9
    • Q5Y7B0
    • Q5Y7B9

    Protein attributes for HLA-DRB1 Gene

    Size:
    266 amino acids
    Molecular mass:
    29966 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides
    Miscellaneous:
    • The chain shown constituted about 70% of a pool of at least seven similar beta chains

    Three dimensional structures from OCA and Proteopedia for HLA-DRB1 Gene

neXtProt entry for HLA-DRB1 Gene

Proteomics data for HLA-DRB1 Gene at MOPED

Other Protein References for HLA-DRB1 Gene

No data available for DME Specific Peptides for HLA-DRB1 Gene

Domains for HLA-DRB1 Gene

Gene Families for HLA-DRB1 Gene

HGNC:
  • C1SET :Immunoglobulin superfamily / C1-set domain containing
  • HLA :Histocompatibility complex

UniProtKB/Swiss-Prot:

2B19_HUMAN
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.:
    • P04229
    • P01912
    • P13760
    • P13761
    • Q30134
    • Q9TQE0
    • Q30167
    • P20039
    • Q95IE3
    • P01911
    • Q29974
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.:
    • Q5Y7A7
    • Q9GIY3
Family:
  • Belongs to the MHC class II family.:
    • P04229
    • P01912
    • P13760
    • P13761
    • Q30134
    • Q9TQE0
    • Q30167
    • P20039
    • Q95IE3
    • Q5Y7A7
    • Q9GIY3
    • P01911
    • Q29974
genes like me logo Genes that share domains with HLA-DRB1: view

Function for HLA-DRB1 Gene

Molecular function for HLA-DRB1 Gene

GENATLAS Biochemistry: HLA-DR,beta 1 chain,determining DR1,3,4,5 etc
UniProtKB/Swiss-Prot Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading
UniProtKB/Swiss-Prot Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading

Gene Ontology (GO) - Molecular Function for HLA-DRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0023026 MHC class II protein complex binding IDA 20458337
GO:0032395 MHC class II receptor activity TAS 3456344
GO:0042605 peptide antigen binding ISS --
genes like me logo Genes that share ontologies with HLA-DRB1: view

miRNA for HLA-DRB1 Gene

miRTarBase miRNAs that target HLA-DRB1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HLA-DRB1 Gene

Localization for HLA-DRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-DRB1 Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HLA-DRB1 Gene COMPARTMENTS Subcellular localization image for HLA-DRB1 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
lysosome 5
plasma membrane 5
vacuole 5
golgi apparatus 4
extracellular 2
nucleus 2
cytoskeleton 1
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HLA-DRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005765 lysosomal membrane TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 3456344
GO:0009897 external side of plasma membrane ISS --
genes like me logo Genes that share ontologies with HLA-DRB1: view

Pathways for HLA-DRB1 Gene

genes like me logo Genes that share pathways with HLA-DRB1: view

Gene Ontology (GO) - Biological Process for HLA-DRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response ISS --
GO:0002437 inflammatory response to antigenic stimulus ISS --
GO:0002455 humoral immune response mediated by circulating immunoglobulin ISS --
GO:0002503 peptide antigen assembly with MHC class II protein complex IDA 1448172
GO:0002506 polysaccharide assembly with MHC class II protein complex IDA 21502329
genes like me logo Genes that share ontologies with HLA-DRB1: view

Compounds for HLA-DRB1 Gene

(1) Drugbank Compounds for HLA-DRB1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Glatiramer Acetate
  • COP-1
147245-92-9 target binder

(17) Novoseek inferred chemical compound relationships for HLA-DRB1 Gene

Compound -log(P) Hits PubMed IDs
dr-10 77.3 4
dr-16 73.6 1
dpa 1 73.1 5
oligonucleotide 53.4 20
gold sodium thiomalate 36 1

(1) PharmGKB related drug/compound annotations for HLA-DRB1 Gene

Drug/compound Annotation
lapatinib
genes like me logo Genes that share compounds with HLA-DRB1: view

Transcripts for HLA-DRB1 Gene

mRNA/cDNA for HLA-DRB1 Gene

Unigene Clusters for HLA-DRB1 Gene

Major histocompatibility complex, class II, DR beta 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-DRB1 Gene

No ASD Table

Relevant External Links for HLA-DRB1 Gene

GeneLoc Exon Structure for
HLA-DRB1
ECgene alternative splicing isoforms for
HLA-DRB1

Expression for HLA-DRB1 Gene

mRNA expression in normal human tissues for HLA-DRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-DRB1 Gene

This gene is overexpressed in Lung (4.1) and Whole Blood (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HLA-DRB1 Gene

SOURCE GeneReport for Unigene cluster for HLA-DRB1 Gene Hs.534322

genes like me logo Genes that share expressions with HLA-DRB1: view

Orthologs for HLA-DRB1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for HLA-DRB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DRB1*0204 37
  • 94 (a)
OneToOne
PATR-DQB1 36
  • 96.62 (n)
  • 93.98 (a)
cow
(Bos Taurus)
Mammalia DSB 37
  • 68 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia DLA-DRB1 37
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia H2-Eb1 16
H2-Eb1 37
  • 75 (a)
ManyToMany
H2-Eb2 37
  • 60 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 55 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 63 (a)
OneToMany
Species with no ortholog for HLA-DRB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HLA-DRB1 Gene

ENSEMBL:
Gene Tree for HLA-DRB1 (if available)
TreeFam:
Gene Tree for HLA-DRB1 (if available)

Paralogs for HLA-DRB1 Gene

Selected SIMAP similar genes for HLA-DRB1 Gene using alignment to 2155 proteins: