 |
 | Services
| |
 |
Aliases &
Descriptions
for HLA-DRB1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| DR-1 3 | | DR-4 3 | | DR-5 3 | | DR-7 3 | | DR-8 3 | | DR-9 3 | | DR1 3 | | DR4 3 | | DR5 3 | | DR7 3 | | DR8 3 | | DR9 3 | | DRB1 2 | | DRw10 3 | | DRw11 3 | | DRw8 3 | | DW2.2/DR2.2 3 | | FLJ75017 2 | | FLJ76359 2 | | HLA-DR1B 2 | | HLA-DRB 2 | | HLA-DRB1* 2 | | HLA-DRB2 3 | | SS1 2 |
| | | Descriptions |
|---|
| Clone P2-beta-3 3 | | HLA class II antigen beta chain 2 | | HLA class II histocompatibility antigen, DR-1 beta chain 2 | | HLA-DR-beta 1 2 | | MHC class I antigen DRB1*1 3 | | MHC class I antigen DRB1*10 3 | | MHC class I antigen DRB1*11 3 | | MHC class I antigen DRB1*15 3 | | MHC class I antigen DRB1*4 3 | | MHC class I antigen DRB1*7 3 | | MHC class I antigen DRB1*8 3 | | MHC class I antigen DRB1*9 3 | | MHC class II HLA-DR beta 1 chain 2 | | MHC class II HLA-DR-beta cell surface glycoprotein 2 | | MHC class II HLA-DRw10-beta 2 | | MHC class II antigen HLA-DR13 2 | | human leucocyte antigen DRB1 2 | | leucocyte antigen DR beta 1 chain 2 | | leucocyte antigen DRB1 2 | | lymphocyte antigen DRB1 2 | | major histocompatibility complex, class II, DR beta 1 2 |
|
| |
Search outside databases for aliases for HLA-DRB1 genePrevious GC identifers: GC06U990049 GC06Md32547 GC06M032317 GC06Md32654 |
Summaries
for HLA-DRB1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for HLA-DRB1:
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer
consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a
central role in the immune system by presenting peptides derived from extracellular proteins.
Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells,
macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one
encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the
transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta
chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of
DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone
marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its
paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are
linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes:
DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq]
Gene Wiki entry for HLA-DRB1 |
Genomic Location
for HLA-DRB1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the HLA-DRB1 gene 
Entrez Gene cytogenetic band: 6p21.3 HGNC cytogenetic band: 6p21.3HLA-DRB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M032656:
(about GC identifiers)
Start:
|
32,654,527 bp from pter |
End:
|
32,665,559 bp from pter |
Size:
|
11,033 bases |
Orientation:
|
minus strand |
3 alternative locations:
| Chr6+,DR53 32,387,629-32,402,323 | Chr6-,c6_COX 32,623,204-32,636,571 | Chr6-,c6_QBL 32,598,479-32,637,444 | |
RefSeq DNA sequence:- NC_000006.10 NT_007592.14 NT_113891.1
| Proteins
for HLA-DRB1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: 2B11_HUMAN, P04229 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DRB1-1 beta chain precursor Size: 266 amino acids; 29914 Da
Subunit: Heterodimer of an alpha chain and a beta chain
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from  and Proteopedia  :1AQD (3D)
1BX2 (3D)
1DLH (3D)
1FYT (3D)
1HXY (3D)
1JWM (3D)
1JWS (3D)
1JWU (3D)
1KG0 (3D)
1KLG (3D)
1KLU (3D)
1LO5 (3D)
1PYW (3D)
1R5I (3D)
1SEB (3D)
1SJE (3D)
1SJH (3D)
1T5W (3D)
1T5X (3D)
2FSE (3D)
2G9H (3D)
2IAM (3D)
2IAN (3D)
2ICW (3D)
2IPK (3D)
2OJE (3D)
Secondary accessions: A4F5N0 A8K098 O62869 P13758 Q06662 Q30116 Q30117 Q5Y7E9 Q7M2H4 Q95461 Q9BCL7
Q9GIK5 Q9MXZ0 Q9MXZ5 Q9TQ91UniProtKB/Swiss-Prot: 2B14_HUMAN, P13760 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DRB1-4 beta chain precursor Size: 266 amino acids; 30112 Da
Subunit: Heterodimer of an alpha chain and a beta chain
Subcellular location: Membrane; Single-pass type I membrane protein
PDB structures from and Proteopedia :1D5M (3D)
1D5X (3D)
1D5Z (3D)
1D6E (3D)
1J8H (3D)
2SEB (3D)
Secondary accessions: O19717 O19739 P13759 Q29875 Q30145 Q9GIX9 Q9GIY4 Q9MY13 Q9XRY5UniProtKB/Swiss-Prot: 2B17_HUMAN, P13761 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DRB1-7 beta chain precursor Size: 266 amino acids; 29822 Da
Subunit: Heterodimer of an alpha chain and a beta chain
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O46699 O46872UniProtKB/Swiss-Prot: 2B18_HUMAN, Q30134 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DRB1-8 beta chain precursor Size: 266 amino acids; 30004 Da
Subunit: Heterodimer of an alpha chain and a beta chain
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: O19718 O19788 Q29968 Q30108 Q30115 Q9BCP0 Q9BCP1 Q9BCP2 Q9BD33 Q9TQ37 Q9UIM9UniProtKB/Swiss-Prot: 2B19_HUMAN, Q9TQE0 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DRB1-9 beta chain precursor Size: 266 amino acids; 29826 Da
Subunit: Heterodimer of an alpha chain and a beta chain
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q30149UniProtKB/Swiss-Prot: 2B1A_HUMAN, Q30167 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DRB1-10 beta chain precursor Size: 266 amino acids; 30074 Da
Subunit: Heterodimer of an alpha chain and a beta chain
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q9MYF5UniProtKB/Swiss-Prot: 2B1B_HUMAN, P20039 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DRB1-11 beta chain precursor Size: 266 amino acids; 30160 Da
Subunit: Heterodimer of an alpha chain and a beta chain
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q30006 Q9GIX8UniProtKB/Swiss-Prot: 2B1E_HUMAN, P01911 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DRB1-15 beta chain precursor Size: 266 amino acids; 29966 Da
Subunit: Heterodimer of an alpha chain and a beta chain (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)
Miscellaneous: The chain shown constituted about 70% of a pool of at least seven similar beta
chains
PDB structure from and Proteopedia :1YMM (3D)
2WBJ (3D)
Secondary accessions: Q29790 Q29975 Q30142 Q30166 Q32MY7 Q56FN9 Q5Y7B0 Q5Y7B9UniProtKB/Swiss-Prot: HB2B_HUMAN, P01912 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DR-1 beta chain precursor Size: 266 amino acids; 30120 Da
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)
PDB structures from and Proteopedia :1A6A (3D)
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002115.2
ENSEMBL proteins: ENSP00000382599 ENSP00000331343 ENSP00000339469
Human Recombinant Proteins  | Browse
Drug Discovery Central at Invitrogen for human recombinant proteins |  | Browse Purified and Recombinant Proteins at Millipore |  | Browse Human Recombinant Proteins at Sigma-Aldrich |  |
Browse R&D Systems for human recombinant proteins |  | Browse recombinant and purified proteins available from Enzo Life Sciences |  | Recombinant Proteins from Abcam (CD13 + HLA DR, HLA Class 1 A30 A31, Guinea pig MHC Class II, HLA DR7+DR beta, HLA DR, CD4 + HLA DR, HLA DR + HLA DP, HLA Class II DR4, HLA Class II DR13, HLA DR beta, HLA Class II DR7, HLA DR + DP + DQ) |  | Human Recombinant Proteins from Abnova (HLA-DRB1) |
 Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for HLA-DRB1: | Invitrogen Antibodies for HLA-DRB1 | | Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies | | Sigma-Aldrich Antibodies for HLA-DRB1 | |
Browse R&D Systems for Antibodies |  | Antibodies from Abcam (CD13 + HLA DR, HLA Class 1 A30 A31, Guinea pig MHC Class II, HLA DR7+DR beta, HLA DR, CD4 + HLA DR, HLA DR + HLA DP, HLA Class II DR4, HLA Class II DR13, HLA DR beta, HLA Class II DR7, HLA DR + DP + DQ), each with their AbpromiseSM | | Monoclonal and Polyclonal Antibodies from Abnova (HLA-DRB1) |  | Novus Biologicals Antibody for HLA-DRB1 |
Assays for HLA-DRB1: | Protein
Domains/
Families
for HLA-DRB1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P04229
- Graphical View of Domain Structure for InterPro Entry P13760
- Graphical View of Domain Structure for InterPro Entry P13761
- Graphical View of Domain Structure for InterPro Entry Q30134
- Graphical View of Domain Structure for InterPro Entry Q9TQE0
- Graphical View of Domain Structure for InterPro Entry Q30167
- Graphical View of Domain Structure for InterPro Entry P20039
- Graphical View of Domain Structure for InterPro Entry P01911
- Graphical View of Domain Structure for InterPro Entry P01912
ProtoNet protein and cluster: P04229 2 Blocks protein families: IPB000353 Class II histocompatibility antigen IPB003597 Immunoglobulin C-type
UniProtKB/Swiss-Prot: 2B11_HUMAN, P04229Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 2B14_HUMAN, P13760Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 2B17_HUMAN, P13761Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 2B18_HUMAN, Q30134Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 2B19_HUMAN, Q9TQE0Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 2B1A_HUMAN, Q30167Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 2B1B_HUMAN, P20039Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: 2B1E_HUMAN, P01911Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: HB2B_HUMAN, P01912Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain | Gene Function
for HLA-DRB1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): BC008403
 Applied Biosystems Silencer® siRNAs for HLA-DRB1
Sigma-Aldrich siRNA for HLA-DRB1
Sigma-Aldrich shRNA Panels and shRNA for HLA-DRB1
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_002124
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002124
untagged cDNA clones in CMV expression vector (see all 5): BC007920
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_002124
Genatlas biochemistry entry for HLA-DRB1:HLA-DR,beta 1 chain,determining DR1,3,4,5 etc1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0032395 | MHC class II receptor activity |
TAS | 3456344 |
About this table | Pathways & Interactions
for HLA-DRB1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
3 Sigma-Aldrich "Your Favorite Gene" Pathways for HLA-DRB1 (Your Favorite Gene powered by Ingenuity)
Gene Network CentralTM Interacting Genes and Proteins Network for HLA-DRB1
2 Interacting proteins for HLA-DRB1 (ENSP000003394693 P019122 P042292, 2) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
IEA | -- | | GO:0006955 | immune response |
IEA | -- |
About this table
|
Drugs & Compounds
for HLA-DRB1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for HLA-DRB1
10/11  Novoseek chemical compound relationships for HLA-DRB1 gene (see all 11
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dr-10 |
77.73 |
6 |
7780115 (1), 9550403 (1), 8754259 (1), 10626740 (1) |
| dr-16 |
73.93 |
1 |
9243764 (1) |
| dpa 1 |
73.54 |
5 |
8782076 (1), 8863870 (1), 17060025 (1), 10616003 (1) (see all 5) |
| oligonucleotide |
53.73 |
20 |
8117375 (1), 12823773 (1), 15865503 (1), 18718089 (1) (see all 19) |
| amino acid |
20.77 |
1 |
1533151 (1) |
| c-peptide |
5.79 |
1 |
15388265 (1) |
| atp |
3.33 |
2 |
12658812 (2) |
| lysine |
0.00 |
2 |
7738179 (1), 7612412 (1) |
| allergens |
0.00 |
1 |
17686102 (1) |
| adp |
0.00 |
2 |
12658812 (2) |
About this table
1 PharmGKB drug compound relationship for HLA-DRB1 gene
| Drug compound |
PharmGKB Relations |
PubMed IDs for articles supporting these relationships |
| cyclosporine | PD | 9277043 | About this table
|
Transcripts
for HLA-DRB1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): BC008403
Sigma-Aldrich siRNA for HLA-DRB1
Sigma-Aldrich shRNA Panels and shRNA for HLA-DRB1
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_002124 REFSEQ mRNAs for HLA-DRB1 gene: NM_002124.2
OriGene GFP tagged cDNA clone in CMV expression vector: NM_002124
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002124
untagged cDNA clones in CMV expression vector (see all 5): BC007920
Additional cDNA sequence: M14191.1 U09201.1 2 DOTS entries: DT.92047682 DT.92410344 24/89 AceView cDNA sequences (see all 89
):M16731 BV201637 AH002891 M17381 AF291675 BV207240 L42143 X02902 BV207185 AJ536121 M15073 AJ297586 BC024269 BV183568 AJ245881 X12544 BV200469 BV200461 BV207036 BV183567 BV207188 AF017440 BV207215 BV207191
 highest scoring ESTs for HLA-DRB1:AJ011065 AU099634 AY626552 AY770514 BC108922 BF976113 BI761102 BM770494 BQ066389 CD102759 Unigene Cluster for HLA-DRB1: Major histocompatibility complex, class II, DR beta 1 Hs.701691 Unigene Representative Sequence: BE397509
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations: ENST00000399692
ENST00000328980
ENST00000339225
|
Expression
for HLA-DRB1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HLA-DRB1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HLA-DRB1
1 / 2 / 3 12 probe-sets matching HLA-DRB1 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.701691
|
Orthologs
for HLA-DRB1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HLA-DRB1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for HLA-DRB1
ENSEMBL Gene Tree for HLA-DRB1 | Paralogs
for HLA-DRB1(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
SNPs/Variants
for HLA-DRB1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| UniProtKB/Swiss-Prot: HB2B_HUMAN, P01912Polymorphism: The following alleles of DRB1-1 are known: DRB1*0101, DRB1*0102, DRB1*0103,
DRB1*0104, DRB1*0105, DRB1*0106 and DRB1*0107. The sequence shown is that of DRB1*0101Polymorphism: The following alleles of DRB1-4 are known: DRB1*0401, DRB1*0402, DRB1*0403, DRB1*0404
and DRB1*0411. The sequence shown is that of DRB1*0401Polymorphism: The following alleles of DRB1-7 are known: DRB1*0701, DRB1*0703 and DRB1*0704
(DRB1*07ROS). The sequence shown is that of DRB1*0701. Allele DRB1*0701 is associated with
persistent hepatitis C virus (HCV) infections [MIM:609532]Polymorphism: The following alleles of DRB1-8 are known: DRB1*0801 (Dw8.1), DRB1*0802 (Dw8.2;
DRB1L), DRB1*0803 (Dw8.3) and DRB1*0804. The sequence shown is that of DRB1*0801Polymorphism: The only allele of DRB1-9 known is DRB1*0901 which is shown herePolymorphism: The only allele of DRB1-10 known is DRB1*1001 which is shown herePolymorphism: The following alleles of DRB1-11 are known: DRB1*1101, DRB1*1103 and DRB1*1104. The
sequence shown is that of DRB1*1101. Allele DRB1*1101 is associated with self-limiting hepatitis C
virus (HCV) infections [MIM:609532]Polymorphism: The following alleles of DRB1-15 are known: DRB1*1501, DRB1*1502, DRB1*1503 and
DRB1*1504. The sequence shown is that of DRB1*1501
HapMap Linkage Disequilibrium images for HLA-DRB1 (up to first 250kb)
|
Disorders & Mutations
for HLA-DRB1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 142857
UniProtKB/Swiss-Prot: HB2B_HUMAN, P01912
Allelic variation at the HLA-DRB1 locus is a major contributor to genetic predisposition
for sarcoidosis [MIM:181000]. Sarcoidosis is a disease of unknown aetiology in which there are
chronic inflammatory granulomatous lesions in lymph nodes and other organs10/53 Novoseek disease relationships for HLA-DRB1 gene (see all 53
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| rheumatoid arthritis |
67.33 |
64 |
1416553 (3), 16277691 (2), 16385499 (2), 10765919 (2) (see all 44) |
| genetic susceptibility |
65.99 |
8 |
17055211 (1), 17047287 (1), 17309132 (1), 18004301 (1) (see all 8) |
| polymyalgia rheumatica |
59.22 |
10 |
10225816 (2), 8147928 (2), 9458210 (2), 15305244 (2) (see all 5) |
| diabetes mellitus insulin-dependent |
51.25 |
2 |
10680451 (1), 7817375 (1) |
| autoimmune diseases |
51.01 |
5 |
16362107 (1), 19117368 (1), 16198136 (1), 1617108 (1) (see all 5) |
| vogt-koyanagi-harada disease |
48.28 |
2 |
7906684 (1), 15603876 (1) |
| autoimmunity |
44.34 |
4 |
16385499 (1), 17987563 (1), 15120192 (1), 8675578 (1) |
| hepatitis autoimmune |
41.89 |
3 |
1350267 (2), 9672174 (1) |
| pemphigus foliaceus |
38.30 |
1 |
9027963 (1) |
| diabetes autoimmune |
36.95 |
2 |
10333055 (1), 18279373 (1) |
About this table
1 PharmGKB disease relationship for HLA-DRB1 geneAbout this table
Human Gene Mutation Database: HLA-DRB1
Genetic Association Database: HLA-DRB1
Human Genome Epidemiology Navigator: HLA-DRB1 (1425 documents)
|
Medical News
for HLA-DRB1(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications
for HLA-DRB1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/1890 PubMed articles for HLA-DRB1 gene (see all 1890
):- [Determination of HLA-DRB1 gene polymorphism in Luoba ethnic group of Tibet] (PubMed id 15898419)1, 3, 6 Kang L.L....Li S.B. (2005)
- Influence of HLA-DRB1 and TNF microsatellite polymorphisms on the expression of extraarticular manifestations in rheumatoid arthritis patients from northwest Spain. (PubMed id 11791643)1, 3, 6 Mattey D.L....Ollier W.E. (2001)
- [Possible association between HLA-HRB1 and DQB1 genes frequency and susceptibility or resistance to Helicobacter pylori infection in Kunming Yi ethnic group children] (PubMed id 15833172)1, 3, 6 Huang Y.K....Zhou L.F. (2005)
- [Association of HLA-A, B, and DR haplotypes with genotype in Chinese children with systemic lupus erythematosus] (PubMed id 14748996)1, 3, 6 Li C.F....Jiang Z.F. (2003)
- Collagenase-1 (MMP-1) and HLA-DRB1 gene polymorphisms in rheumatoid arthritis: a prospective longitudinal study. (PubMed id 11824952)1, 3, 6 Constantin A....Cantagrel A. (2002)
- HLA-DRB1 and HLA-DQB1 polymorphisms in Pacific Islands populations. (PubMed id 12144623)1, 3, 6 Velickovic Z.M....Carter J.M. (2002)
- Association between protein tyrosine phosphatase 22 variant R620W in conjunction with the HLA-DRB1 shared epitope and humoral autoimmunity to an immunodominant epitope of cartilage-specific type II collagen in early rheumatoid arthritis. (PubMed id 16385499)1, 3, 6 Burkhardt H....Reis A. (2006)
- [Polymorphism of HLA-A,-B and DRB1 in Han population of Shanxi province] (PubMed id 16215957)1, 3, 6 Lan T....Wang G.Q. (2005)
- The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis. (PubMed id 16277691)1, 3, 6 Turesson C....Matteson E.L. (2005)
- Epistatic interactions between HLA-DRB1 and interleukin 4, but not interferon-gamma, increase susceptibility to giant cell arteritis. (PubMed id 15570643)1, 3, 6 Amoli M.M....Ollier W.E. (2004)
|
Search for HLA-DRB1
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HLA-DRB1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HLA-DRB1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HLA-DRB1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for HLA-DRB1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for HLA-DRB1:
 | |
 | | | | |
 |
 |  |  | |
|  | Recombinant Proteins
(CD13 + HLA DR, HLA Class 1 A30 A31, Guinea pig MHC Class II, HLA DR7+DR beta, HLA DR, CD4 + HLA DR, HLA DR + HLA DP, HLA Class II DR4, HLA Class II DR13, HLA DR beta, HLA Class II DR7, HLA DR + DP + DQ) | | | Antibodies (CD13 + HLA DR, HLA Class 1 A30 A31, Guinea pig MHC Class II, HLA DR7+DR beta, HLA DR, CD4 + HLA DR, HLA DR + HLA DP, HLA Class II DR4, HLA Class II DR13, HLA DR beta, HLA Class II DR7, HLA DR + DP + DQ) |
| |
|
 |
 | | |
|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|
V3 here soon-try beta now
