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HLA-DRA Gene(Protein Coding)

Major Histocompatibility Complex, Class II, DR Alpha

GCID:
GC06P032412
GIFtS:
64
Genes Participants
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Aliases for HLA-DRA Gene

Aliases for HLA-DRA Gene

  • Major Histocompatibility Complex, Class II, DR Alpha 2 3 5
  • MHC Class II Antigen DRA 3 4
  • HLA-DRA1 3 4
  • HLA Class II Histocompatibility Antigen, DR Alpha Chain 3
  • Histocompatibility Antigen HLA-DR Alpha 3

External Ids for HLA-DRA Gene

Previous HGNC Symbols for HLA-DRA Gene

  • HLA-DRA1

Previous GeneCards Identifiers for HLA-DRA Gene

  • GC06P032434
  • GC06Pd32422
  • GC06P032178

Summaries for HLA-DRA Gene

Entrez Gene Summary for HLA-DRA Gene

  • HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008]

CIViC summary for HLA-DRA Gene

GeneCards Summary for HLA-DRA Gene

HLA-DRA (Major Histocompatibility Complex, Class II, DR Alpha) is a Protein Coding gene. Diseases associated with HLA-DRA include Penicillin Allergy and Graham-Little-Piccardi-Lassueur Syndrome. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include peptide antigen binding and MHC class II receptor activity. An important paralog of this gene is HLA-DPA1.

UniProtKB/Swiss-Prot for HLA-DRA Gene

  • Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Gene Wiki entry for HLA-DRA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-DRA Gene

Genomics for HLA-DRA Gene

Products:

  1. Regulatory Element

Regulatory Elements for HLA-DRA Gene

Enhancers for HLA-DRA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G032435 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.4 -0.4 -405 7.5 HDGF PKNOX1 ATF1 WRNIP1 SIN3A YY1 CBX5 ZNF143 ZNF207 FOS HLA-DRB1 HLA-DQB1 HLA-DRB5 HLA-DQA2 HLA-DRB6 C4A HLA-DQA1 HLA-DQB1-AS1 HLA-DRA PSMB8
GH06G032633 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.1 +197.2 197163 7.2 HDGF WRNIP1 FEZF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF416 ZNF143 ZNF662 HLA-DQA1 HLA-DQB1 HLA-DQA2 HLA-DRB1 HLA-DQB2 HLA-DRB5 HLA-DRB6 PPT2 CYP21A1P HLA-DQB1-AS1
GH06G032602 1.9 FANTOM5 Ensembl ENCODE dbSUPER 7.9 +167.3 167331 10.3 HDGF PKNOX1 ATF1 ZNF143 FOS ZNF263 NFYC JUNB ZNF623 TBX21 HLA-DRB1 HLA-DRB5 HLA-DQA1 HLA-DQA2 HLA-DRB6 C4A HLA-DQB2 HLA-DOB HLA-DQB1 HLA-DMA
GH06G032462 0.9 FANTOM5 15.8 +23.0 23041 0.2 PKNOX1 ZNF76 ZSCAN5C ZNF143 RELB IKZF2 CREM EGR2 SP3 JUNB HLA-DRB5 HLA-DRA HLA-DMA STK19 PSMB8 HLA-DMB HLA-DQB1 HLA-DRB1 GC06P032458 HLA-DRB9
GH06G032621 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.7 +185.4 185381 8.3 PKNOX1 WRNIP1 FEZF1 ZNF2 ZNF143 ZNF207 JUNB TBX21 ZNF610 NBN HLA-DRB1 HLA-DQA2 HLA-DRB6 HLA-DQB1 HLA-DRB5 HLA-DQB2 HLA-DQA1 CYP21A1P HLA-DQB1-AS1 HLA-DPB1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HLA-DRA on UCSC Golden Path with GeneCards custom track

Promoters for HLA-DRA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195680 558 1201 TBP ATF1 TBL1XR1 WRNIP1 BMI1 RFX5 CBX5 ZNF143 ZNF207 FOS

Transcription factor binding sites by QIAGEN in the HLA-DRA gene promoter:

Genomic Location for HLA-DRA Gene

Chromosome:
6
Start:
32,439,842 bp from pter
End:
32,445,046 bp from pter
Size:
5,205 bases
Orientation:
Plus strand

Genomic View for HLA-DRA Gene

Genes around HLA-DRA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-DRA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-DRA Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HLA-DRA Gene

Proteins for HLA-DRA Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HLA-DRA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01903-DRA_HUMAN
    Recommended name:
    HLA class II histocompatibility antigen, DR alpha chain
    Protein Accession:
    P01903
    Secondary Accessions:
    • A2BET4
    • Q30160
    • Q6IAZ1
    • Q861I2
    • Q9TP70

    Protein attributes for HLA-DRA Gene

    Size:
    254 amino acids
    Molecular mass:
    28607 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides. Interacts with Epstein-Barr virus BZLF2/gp42.
    SequenceCaution:
    • Sequence=CAA25076.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HLA-DRA Gene

neXtProt entry for HLA-DRA Gene

Protein Expression for HLA-DRA Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HLA-DRA Gene

  • Ubiquitinated by MARCH1 or MARCH8 at Lys-244 leading to down-regulation of MHC class II. When associated with ubiquitination of the beta subunit of HLA-DR: HLA-DRB4 Lys-254, the down-regulation of MHC class II may be highly effective.
  • Ubiquitination at posLast=244244
  • Glycosylation at posLast=103103 and posLast=143143
  • Modification sites at PhosphoSitePlus

Other Protein References for HLA-DRA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for HLA-DRA
  • Cloud-Clone Corp. Antibodies for HLA-DRA

No data available for DME Specific Peptides for HLA-DRA Gene

Domains & Families for HLA-DRA Gene

Gene Families for HLA-DRA Gene

HGNC:

Protein Domains for HLA-DRA Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HLA-DRA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01903

UniProtKB/Swiss-Prot:

DRA_HUMAN :
  • Belongs to the MHC class II family.
Family:
  • Belongs to the MHC class II family.
genes like me logo Genes that share domains with HLA-DRA: view

Function for HLA-DRA Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line
  7. Flow Cytometry

Molecular function for HLA-DRA Gene

GENATLAS Biochemistry:
HLA-DR,alpha chain
UniProtKB/Swiss-Prot Function:
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Gene Ontology (GO) - Molecular Function for HLA-DRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9354468
GO:0023026 MHC class II protein complex binding IDA 20458337
GO:0032395 MHC class II receptor activity NAS 6304715
GO:0042605 peptide antigen binding IDA 1448172
genes like me logo Genes that share ontologies with HLA-DRA: view
genes like me logo Genes that share phenotypes with HLA-DRA: view

Human Phenotype Ontology for HLA-DRA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-DRA Gene

Localization for HLA-DRA Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-DRA Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLA-DRA gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
lysosome 5
golgi apparatus 5
endosome 5
nucleus 1

Gene Ontology (GO) - Cellular Components for HLA-DRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005764 lysosome IDA 8890155
GO:0005765 lysosomal membrane TAS --
GO:0005768 endosome IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with HLA-DRA: view

Pathways & Interactions for HLA-DRA Gene

genes like me logo Genes that share pathways with HLA-DRA: view

Interacting Proteins for HLA-DRA Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000378786%0d%0a9606.ENSP00000364114%0d%0a9606.ENSP00000353099%0d%0a9606.ENSP00000160827%0d%0a9606.ENSP00000370343%0d%0a9606.ENSP00000350911%0d%0a
Selected Interacting proteins: ENSP00000378786 P01903-DRA_HUMAN for HLA-DRA Gene via STRING MINT IID

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
HLA-DRB1
CD74

Gene Ontology (GO) - Biological Process for HLA-DRA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002503 peptide antigen assembly with MHC class II protein complex IDA 1448172
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA,IDA 21502329
GO:0002506 polysaccharide assembly with MHC class II protein complex IDA 21502329
GO:0006955 immune response NAS,IEA 6304715
genes like me logo Genes that share ontologies with HLA-DRA: view

No data available for SIGNOR curated interactions for HLA-DRA Gene

Drugs & Compounds for HLA-DRA Gene

Products:

  1. Drug

(1) Drugs for HLA-DRA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HLA-DRA: view

Transcripts for HLA-DRA Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for HLA-DRA Gene

(1) REFSEQ mRNAs :
(18) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HLA-DRA Gene

Major histocompatibility complex, class II, DR alpha:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-DRA Gene

No ASD Table

Relevant External Links for HLA-DRA Gene

GeneLoc Exon Structure for
HLA-DRA
ECgene alternative splicing isoforms for
HLA-DRA

Expression for HLA-DRA Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HLA-DRA Gene

mRNA expression in normal human tissues for HLA-DRA Gene
mRNA expression by BioGPS for HLA-DRA GenemRNA expression by GTEx for HLA-DRA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-DRA Gene

This gene is overexpressed in Whole Blood (x5.0) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for HLA-DRA Gene

This gene is overexpressed in Nasal epithelium (16.5), Lymph node (13.1), and Lung (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HLA-DRA Gene



Protein tissue co-expression partners for HLA-DRA Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for HLA-DRA Gene:

Hs.520048

Evidence on tissue expression from TISSUES for HLA-DRA Gene

  • Lung(4.8)
  • Blood(4.7)
  • Intestine(4.6)
  • Liver(4.5)
  • Pancreas(3.8)
  • Nervous system(3.6)
  • Skin(3.5)
  • Spleen(3.4)
  • Kidney(2.7)
  • Stomach(2.7)
  • Lymph node(2.6)
  • Heart(2.3)
  • Muscle(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-DRA Gene

Germ Layers:
  • ectoderm
Systems:
  • integumentary
Organs:
Limb:
  • nail
General:
  • hair
  • skin
genes like me logo Genes that share expression patterns with HLA-DRA: view

No data available for mRNA Expression by UniProt/SwissProt for HLA-DRA Gene

Orthologs for HLA-DRA Gene

This gene was present in the common ancestor of chordates.

Orthologs for HLA-DRA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia PATR-DRA 34 35
  • 98.95 (n)
dog
(Canis familiaris)
 Mammalia DLA-DRA 34
  • 89.5 (n)
DLA-DRA1 35
  • 87 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia BOLA-DRA 34 35
  • 85.24 (n)
rat
(Rattus norvegicus)
 Mammalia RT1-Da 34
  • 79.28 (n)
mouse
(Mus musculus)
 Mammalia H2-Ea-ps 34 16
  • 76.75 (n)
oppossum
(Monodelphis domestica)
 Mammalia HLA-DRA 35
  • 68 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-1342 35
  • 63 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves BLA 34
  • 57.82 (n)
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 55 (a)
 ManyToMany
-- 35
  • 53 (a)
 ManyToMany
zebrafish
(Danio rerio)
 Actinopterygii zgc:123107 35
  • 30 (a)
 ManyToMany
Species where no ortholog for HLA-DRA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HLA-DRA Gene

ENSEMBL:
Gene Tree for HLA-DRA (if available)
TreeFam:
Gene Tree for HLA-DRA (if available)

Paralogs for HLA-DRA Gene

Paralogs for HLA-DRA Gene

(9) SIMAP similar genes for HLA-DRA Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HLA-DRA: view

Variants for HLA-DRA Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DRA Gene

DRA_HUMAN-P01903
Genetic variations in HLA-DRA influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424].
DRA_HUMAN-P01903
The following alleles of DRA are known: DRA*01:01 and DRA*01:02. The sequence shown is that of DRA*01:01.

Sequence variations from dbSNP and Humsavar for HLA-DRA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000321440 -- 32,439,026(+) TGAGA(C/T)CACGC upstream-variant-2KB
rs1001105789 -- 32,442,921(+) AGTCA(C/T)TGCCC intron-variant
rs1001627549 -- 32,443,916(+) GGCAC(A/G)TGGAG utr-variant-3-prime
rs1002014506 -- 32,444,187(+) ACATT(A/G)GAATA intron-variant
rs1004181694 -- 32,441,732(+) TTCCA(C/T)AGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HLA-DRA Gene

Variant ID Type Subtype PubMed ID
dgv10404n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
dgv10472n54 CNV loss 21841781
dgv5945n100 CNV gain 25217958
esv21985 CNV gain+loss 19812545
esv2759416 CNV gain+loss 17122850
esv33476 CNV gain+loss 17666407
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv428142 CNV gain+loss 18775914
nsv602111 CNV loss 21841781
nsv830630 CNV loss 17160897
nsv830631 CNV gain 17160897

Variation tolerance for HLA-DRA Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HLA-DRA Gene

Human Gene Mutation Database (HGMD)
HLA-DRA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HLA-DRA

Disorders for HLA-DRA Gene

MalaCards: The human disease database

(10) MalaCards diseases for HLA-DRA Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
penicillin allergy
  • allergy to penicillin
graham-little-piccardi-lassueur syndrome
  • graham little syndrome
heart lymphoma
  • lymphoma of heart
keshan disease
  • caused by deficiency of selenium in the diet
allergic encephalomyelitis
  • experimental autoimmune encephalomyelitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HLA-DRA

Genetic Association Database (GAD)
HLA-DRA
Human Genome Epidemiology (HuGE) Navigator
HLA-DRA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HLA-DRA
genes like me logo Genes that share disorders with HLA-DRA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HLA-DRA Gene

Publications for HLA-DRA Gene

  1. The HLA-DRA*0102 allele: correct nucleotide sequence and associated HLA haplotypes. (PMID: 12445311) Kralovicova J. … Vorechovsky I. (Tissue Antigens 2002) 3 4 22 64
  2. A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia. (PMID: 22541561) Zhao H. … Chen Z.J. (Am. J. Hum. Genet. 2012) 3 46 64
  3. Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. (PMID: 21779181) Gorlova O. … Martin J. (PLoS Genet. 2011) 3 46 64
  4. Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. (PMID: 21804548) Hirota T. … Tamari M. (Nat. Genet. 2011) 3 46 64
  5. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E. … Dorak M.T. (Mol. Hum. Reprod. 2010) 3 46 64

Products for HLA-DRA Gene

Sources for HLA-DRA Gene

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