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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLA-DQB3 Gene

pseudogene   GIFtS: 22
GCID: GC06M032700

Major Histocompatibility Complex, Class II, DQ Beta 3


(Previous symbol: HLA-DVB)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Major Histocompatibility Complex, Class II, DQ Beta 31 2     DQB32
HLA-DVB1 2     DVB2
D6S2052     DVbeta2
D6S205E2     

External Ids:    HGNC: 49461   Entrez Gene: 31212   Ensembl: ENSG000002260307   UniProtKB: O782194   UniProtKB: Q297834   
UniProtKB: Q299654   

Export aliases for HLA-DQB3 gene to outside databases

Previous GC identifers: GC06U990048 GC06M032674 GC06M032677 GC06M032726 GC06M032806


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for HLA-DQB3 Gene: 
HLA-DQB3 (major histocompatibility complex, class II, DQ beta 3) is a pseudogene. Diseases associated with HLA-DQB3 include hypersensitivity reaction type ii disease, and diabetes mellitus, and among its related super-pathways are Immune response ICOS pathway in T-helper cell and Immune response NFAT in immune response.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for HLA-DQB3
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HLA-DQB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DQB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

HLA-DQB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-DQB3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032700:  view genomic region     (about GC identifiers)

Start:
32,698,535 bp from pter      End:
32,699,472 bp from pter
Size:
938 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/TrEMBL: O78219 (See protein sequence)
Recommended Name: Lymphocyte antigen precursor  
Size: 126 amino acids; 14688 Da

UniProtKB/TrEMBL: Q29783 (See protein sequence)

Recommended Name: Cell surface glycoprotein  
Size: 89 amino acids; 9703 Da

UniProtKB/TrEMBL: Q29965 (See protein sequence)

Recommended Name: Lymphocyte antigen precursor  
Size: 126 amino acids; 14840 Da


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
HLA: Histocompatibility complex

3 InterPro protein domains:
 IPR011162 MHC_I/II-like_Ag-recog
 IPR000353 MHC_II_b_N
 IPR014745 MHC_II_a/b_N

Graphical View of Domain Structure for InterPro Entry O78219
Graphical View of Domain Structure for InterPro Entry Q29783
Graphical View of Domain Structure for InterPro Entry Q29965

ProtoNet protein and cluster: O78219


HLA-DQB3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:
     Genatlas biochemistry entry for HLA-DQB3:
HLA-DQ,beta-chain related,not known to be expressed

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for HLA-DQB3 About   (see all 6)                                                                                              See pathways by source

SuperPathContained pathways About
1Immune response ICOS pathway in T-helper cell
Immune response ICOS pathway in T-helper cell0.91
2Immune response NFAT in immune response
Immune response NFAT in immune response0.90
3Immune response T cell receptor signaling pathway
Immune response T cell receptor signaling pathway0.88
4Immune response IL-22 signaling pathway
Immune response IL-22 signaling pathway0.87
5G-protein signaling N-RAS regulation pathway
G-protein signaling N-RAS regulation pathway0.83

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

5/6 EMD Millipore Pathways for HLA-DQB3 (see all 6)
    Immune response Antigen presentation by MHC class II
G-protein signaling N-RAS regulation pathway
Immune response IL-22 signaling pathway
Immune response NFAT in immune response
Immune response ICOS pathway in T-helper cell


5/6 GeneGo (Thomson Reuters) Pathways for HLA-DQB3 (see all 6)
    Immune response Antigen presentation by MHC class II
Immune response ICOS pathway in T-helper cell
Immune response T cell receptor signaling pathway
Immune response IL-22 signaling pathway
G-protein signaling N-RAS regulation pathway



HLA-DQB3 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HLA-DQB3

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HLA-DQB3

Search CenterWatch for drugs/clinical trials and news about HLA-DQB3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000425319
miRNA
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                     Customized lentivirus expression plasmids for stable overexpression of HLA-DQB3 
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HLA-DQB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
HLA-DQB3 Expression
About this image

    SABiosciences Custom PCR Arrays for HLA-DQB3
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DQB3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for HLA-DQB3 (if available)
TreeFam Gene Tree for HLA-DQB3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for HLA-DQB3 gene
18/96 SIMAP similar genes for HLA-DQB3 using alignment to 3 protein entries:     O78219_HUMAN (see all proteins) (see all similar genes):
HLA-DQ3    HLA DQB1    HLA-DQ-beta    HLA-DQB1*03    DQB1*0603    HLA-DQB
HLA-DQB1    HLA-DQB1I    DQB1    HLA-DQB1*06new1    HLA-DQB1*06x    DQB1.SLE
HLA-DQ    DQB1-02    HLA-DQB1/DRB1    HLA-DQB1*05    HLA-DR4/Dw13    HLA-D8.2V

HLA-DQB3 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Locus Specific Mutation Databases (LSDB): HLA-DQB3
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing HLA-DQB3
DNA2.0 Custom Variant and Variant Library Synthesis for HLA-DQB3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for HLA-DQB3:    About MalaCards
hypersensitivity reaction type ii disease    diabetes mellitus

3 diseases from the University of Copenhagen DISEASES database for HLA-DQB3:
Diabetes mellitus     Rheumatoid arthritis     Hypersensitivity reaction type II disease

HLA-DQB3 for disorders           About GeneDecksing


Export disorders for HLA-DQB3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for HLA-DQB3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HLA-DQB3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system. (PubMed id 1529427)1, 3 Bodmer J.G....Sasazuki T. (1992)
  2. Mapping and nucleotide sequence of a new HLA class II light chain gene, DQB3. (PubMed id 2571586)1, 3 Ando A....Inoko H. (1989)
  3. Mapping, nucleotide sequence, and polymorphism of a new HLA class II light chain gene. (PubMed id 2495625)1 Inoko H....Tsuji K. (1989)
  4. Sequence analysis of HLA class II genes from insulin-dependent diabetic individuals. (PubMed id 3372263)1 Horn G.T.... Erlich H.A. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3121 HGNC: 4946 Ensembl:ENSG00000226030 euGenes: HUgn3121 ECgene: HLA-DQB3
H-InvDB: HLA-DQB3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for HLA-DQB3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for HLA-DQB3 gene:
Search GeneIP for patents involving HLA-DQB3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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