HLA-DQB2 Gene
protein-coding GIFtS: 48
GCID: GC06M032728
|
|
major histocompatibility complex, class II, DQ beta 2
(Previous symbol: HLA-DXB)
| |
Aliases
for HLA-DQB2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Major Histocompatibility Complex, Class II, DQ Beta 21 2 | | HLA-DQB12 | | HLA-DXB1 2 3 | | DV19.1 (Major Histocompatibility Complex, Class II, DQ Beta 2 (HLA-DXB))2 | | HLA Class II Histocompatibility Antigen, DX Beta Chain2 3 | | HLA Class II Histocompatibility Antigen, DQ Beta 2 Chain2 | | MHC Class II Antigen DQB22 3 | | Major Histocompatibility Complex, Class II, DQ Beta 12 |
Export aliases for HLA-DQB2 gene to outside databasesPrevious GC identifers: GC06U990047 GC06M032721 GC06M032676 GC06M032077 GC06M032831 GC06M032725 |
Summaries
for HLA-DQB2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HLA-DQB2:
HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting ofan alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system bypresenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells(APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptidebinding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. Howeverthis gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There isconflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2.Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq asa protein-coding locus. (provided by RefSeq, Oct 2010)
UniProtKB/Swiss-Prot: DQB2_HUMAN, P05538Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) andpresents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptidesof 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteinsthat access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenousantigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, andfor this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on theirway to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomalcompartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also asource of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In additionto APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents anantigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in theER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigenprocessing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving asmall fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DMvia direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II moleculesuntil primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transportedto the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated byHLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in theregulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis andefficient peptide loading
Gene Wiki entry for HLA-DQB2
|
Genomic Views
for HLA-DQB2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167247.1
- NT_167248.1 NT_167249.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HLA-DQB2 gene promoter:
HOXA9 HOXA9B AML1a HTF HNF-4alpha2 Meis-1b HNF-4alpha1 Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HLA-DQB2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DQB2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.3HLA-DQB2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M032728: view genomic region
(about GC identifiers)
Start:
|
32,723,875 bp from pter |
End:
|
32,731,330 bp from pter |
Size:
|
7,456 bases |
Orientation:
|
minus strand |
6/7 alternative locations (see all 7):
| Chr6-,ALT_REF_LOCI_4 32,800,729-32,808,187 | Chr6-,ALT_REF_LOCI_5 32,672,481-32,679,939 | Chr6-,ALT_REF_LOCI_6 32,652,598-32,695,637 | | Chr6-,ALT_REF_LOCI_3 32,703,042-32,721,538 | Chr6-,ALT_REF_LOCI_2 32,647,573-32,694,217 | Chr6-,ALT_REF_LOCI_1 32,708,756-32,724,512 | |
|
Proteins
for HLA-DQB2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DQB2_HUMAN, P05538 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DQ beta 2 chain precursor Size: 268 amino acids; 30387 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmicreticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariantchain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoessequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHCclass II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding ofantigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-passtype I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosomemembrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHCclass II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches thecell membrane for antigen presentation
Caution: This gene appears not to be expressed
Sequence caution: Sequence=CAA60790.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6NIA5 Q29826 Q29870 Q29871 Q29872 Q29873 Q5SR06Alternative splicing: 2 isoforms: P05538-1 P05538-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for HLA-DQB2: NX_P05538
HLA-DQB2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001185787.1
ENSEMBL proteins: ENSP00000396330 ENSP00000410512 ENSP00000390431 ENSP00000415997 Reactome Protein details: P05538
Human Recombinant Protein Products:
Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16): About this table
HLA-DQB2 for ontologies About GeneDecksing
HLA-DQB2 Antibody Products:
Assay Products for HLA-DQB2: |
Protein
Domains /
Families
for HLA-DQB2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HLA-DQB2 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P05538ProtoNet protein and cluster: P05538 3 Blocks protein families: IPB000353 Class II histocompatibility antigen IPB001003 MHC Class II alpha chain IPB003597 Immunoglobulin C-type
UniProtKB/Swiss-Prot: DQB2_HUMAN, P05538Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain |
Function
for HLA-DQB2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DQB2_HUMAN, P05538Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) andpresents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptidesof 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteinsthat access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenousantigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, andfor this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on theirway to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomalcompartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also asource of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In additionto APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents anantigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in theER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigenprocessing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving asmall fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DMvia direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II moleculesuntil primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transportedto the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated byHLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in theregulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis andefficient peptide loading Genatlas biochemistry entry for HLA-DQB2:HLA-DQ,beta chain-related,not known to be expressed
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DQB2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DQB2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HLA-DQB2 (NM_001198858) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HLA-DQB2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DQB2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DQB2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
HLA-DQB2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for HLA-DQB2:
|
Pathways & Interactions
for HLA-DQB2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Transport of MHC II:Ii complex along Golgi to TGN | | | 2 | Translocation of ZAP-70 to Immunological synapse | | | 3 | Immune response_NFAT in immune response | | | 4 | Immune response_ICOS pathway in T-helper cell | | | 5 | Immune response_Antigen presentation by MHC class II | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 EMD Millipore Pathways for HLA-DQB2 (see all 6)
5/6  GeneGo (Thomson Reuters) Pathways for HLA-DQB2 (see all 6)
5/20 
Reactome Pathways for HLA-DQB2 (see all 20)
HLA-DQB2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLA-DQB2
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002344 | B cell affinity maturation |
-- | -- | | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
-- | -- | | GO:0002579 | positive regulation of antigen processing and presentation |
-- | -- | | GO:0002827 | positive regulation of T-helper 1 type immune response |
-- | -- | | GO:0006955 | immune response |
NAS | 2564844 |
HLA-DQB2 for ontologies About GeneDecksing
|
Drugs & Compounds
for HLA-DQB2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HLA-DQB2
Search CenterWatch for drugs/clinical trials and news about HLA-DQB2 / DQB2
|
Transcripts
for HLA-DQB2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HLA-DQB2 gene (2 alternative transcripts): NM_001198858.1 NM_182549.1 Unigene Cluster for HLA-DQB2: Major histocompatibility complex, class II, DQ beta 2 Hs.731563 [show with all ESTs]Unigene Representative Sequence: AK0980074 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000437316(uc003oby.4) ENST00000435145(uc003obz.2) ENST00000411527
ENST00000427449
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DQB2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DQB2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HLA-DQB2 (NM_001198858) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HLA-DQB2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DQB2 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-DQB2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HLA-DQB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DQB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DQB2 |
Additional cDNA sequence: AK098007.1 BC031995.1 M95729.1 16 DOTS entries: DT.121314578 DT.121314508 DT.95274661 DT.85104317 DT.92443956 DT.121314743 DT.87078525 DT.121314811 DT.40250885 DT.87078313 DT.92404855 DT.121314814 DT.92443957 DT.121314570 DT.121314712 DT.95274643 18 AceView cDNA sequences: M95729 BG545654 BG680248 CD694814 BG675599 AK098007 CA309454 BX092875 BC031995 NM_182549 BI833727 BG538183 CD709138 T96621 CD687717 CD684765 BE046094 T96731
GeneLoc Exon Structure
|
Expression
for HLA-DQB2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HLA-DQB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACAAACAAAA
About this image
See HLA-DQB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HLA-DQB2
SOURCE GeneReport for Unigene cluster: Hs.731563
SABiosciences Custom PCR Arrays for HLA-DQB2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-DQB2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HLA-DQB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DQB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DQB2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DQB2 |
Orthologs
for HLA-DQB2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HLA-DQB2 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for HLA-DQB2 (if available)
TreeFam Gene Tree for HLA-DQB2 (if available) |
Paralogs
for HLA-DQB2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HLA-DQB2 gene
- HLA-DRB52 HLA-DQA12 HLA-DPA12 HLA-DQB12 HLA-DRA2 HLA-DOB2 HLA-DRB12 HLA-DMA2
- HLA-DOA2 ENSG000002489932 HLA-DMB2 HLA-DQA22 HLA-DPB12
18/114 SIMAP similar genes for HLA-DQB2 using alignment to 17 protein entries: DQB2_HUMAN (see all proteins)
(see all similar genes):HLQ-DQB1 HLA-DQ-beta HLA-DQB HLA-DQ3 HLA-DQB1*06x HLA DQB1
HLA DRB4 HLA-DQ HLA-DQB1 HLA-Dw12 HLA-DRB4*0102 HLA-DQB3
HLA-DQB1/DRB1 HLA-DRB13 MHC Class II HLA DRB1 DQB1-02 HLA-DRB2 HLA-D8.2V
HLA-DQB2 for paralogs About GeneDecksing
|
Genomic Variants
for HLA-DQB2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HLA-DQB2 (32723875 - 32731330 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for HLA-DQB2
4 CNVs: 69417 62501 64476 69419
Locus Specific Mutation Databases (LSDB): HLA-DQB2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-DQB2 |
|
Disorders
/ Diseases
for HLA-DQB2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HLA-DQB2 for disorders About GeneDecksing
11  diseases for HLA-DQB2: About MalaCardsspermatic cord torsion chronic interstitial cystitis coronary artery aneurysm systemic lupus erythematosus
lupus erythematosus kawasaki disease rheumatoid arthritis hepatitis b
arthritis hepatitis immunodeficiency
Genetic Association Database (GAD): HLA-DQB2
Human Genome Epidemiology (HuGE) Navigator: HLA-DQB2 (7 documents)
Export disorders for HLA-DQB2 gene to outside databases
|
Publications
for HLA-DQB2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HLA-DQB2 gene, integrated from 9 sources (see all 66):
(articles sorted by number of sources associating them with HLA-DQB2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Remarkable sequence conservation of the HLA-DQB2 locus (DX beta) within the highly polymorphic DQ subregion of the human MHC. (PubMed id 2564844)1, 2, 3 Berdoz J.... Gorski J. (1989)
- Analysis of single-nucleotide polymorphisms in Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic shared epitope susceptibility sequences. (PubMed id 14730600)1, 4 Kochi Y....Yamamoto K. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Absence of in vivo DNA-protein interactions in the DQA2 and DQB2 promoter regions. (PubMed id 11334674)1, 2 Indovina P....Mazzilli M.C. (2001)
- Evolutionary dynamics of non-coding sequences within the class II region of the human MHC. (PubMed id 8568858)1, 2 Beck S.... Trowsdale J. (1996)
- Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes. (PubMed id 3036828)1, 2 Jonsson A.-K.... Rask L. (1987)
- Gene organization of DC and DX subregions of the human major histocompatibility complex. (PubMed id 3858830)1, 2 Okada K.... Strominger J.L. (1985)
- HIV-1 Gag-virus-like particles induce natural killer c ell immune responses via activation and maturation of dendritic cells. (PubMed id 21778700)1 Chang M.O....Takaku H. (2012)
- HLA-DQA2 and HLA-DQB2 genes are specifically expressed in human Langerhans cells and encode a new HLA class II molecule. (PubMed id 22407913)1 Lenormand C....Tourne S. (2012)
- A genome-wide association study identifies three new r isk loci for Kawasaki disease. (PubMed id 22446962)1 Onouchi Y.... . (2012)
|
External Searches for HLA-DQB2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HLA-DQB2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing HLA-DQB2 gene
(According to HUGE)
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Specialized Databases showing HLA-DQB2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for HLA-DQB2 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for HLA-DQB2 gene:
Search GeneIP for patents involving HLA-DQB2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HLA-DQB2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HLA-DQB2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLA-DQB2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-DQB2 | | | OriGene Protein Over-expression Lysate for HLA-DQB2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HLA-DQB2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DQB2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DQB2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HLA-DQB2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HLA-DQB2 | | OriGene Custom Protein Services for HLA-DQB2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HLA-DQB2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-DQB2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DQB2 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-DQB2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DQB2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DQB2 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DQB2 |
|  |  |  | | | | Search ThermoFisher Antibodies for HLA-DQB2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DQB2 |
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