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Aliases &
Descriptions
for HLA-DQB1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| CELIAC1 1, 2, 5 | | DC-1 3 | | DQ(5) 3 | | DQB1*0501 3 | | HLA-DQB 2, 3 | | HLA-DRB1 3 | | IDDM1 1, 2 | | OTTHUMP00000178570 2 |
| | | Descriptions |
|---|
| Clone II-102 3 | | DC-3 beta chain 3 | | MHC DQ beta 2 | | MHC class II DQ beta chain 2 | | MHC class II HLA-DQ beta glycoprotein 2 | | MHC class II antigen DQB1 2 | | MHC class II antigen HLA-DQ-beta-1 2 | | MHC class2 antigen 2 | | lymphocyte antigen 2 | | major histocompatibility complex class II beta 2 | | major histocompatibility complex, class II, DQ beta 1 2 |
|
| |
Search outside databases for aliases for HLA-DQB1 genePrevious GC identifers: GC06U990046 GC06M032623 GC06M032398 GC06M032675 GC06M032678 GC06M032727 |
Summaries
for HLA-DQB1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for HLA-DQB1:
HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer
consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a
central role in the immune system by presenting peptides derived from extracellular proteins.
Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells,
macrophages). The beta chain is approximately 26-28 kDa and it contains 6 exons. Exon one encodes
the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the
transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the
alpha chain and the beta chain contain the polymorphisms specifying the peptide binding
specificities, resulting in up to 4 different molecules. Typing for these polymorphisms is
routinely done for bone marrow transplantation. [provided by RefSeq]
Gene Wiki entry for HLA-DQB1 |
Genomic Location
for HLA-DQB1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the HLA-DQB1 gene 
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.3HLA-DQB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M032735:
(about GC identifiers)
Start:
|
32,735,222 bp from pter |
End:
|
32,754,296 bp from pter |
Size:
|
19,075 bases |
Orientation:
|
minus strand |
2 alternative locations:
| Chr6-,c6_COX 32,697,128-32,704,981 | Chr6-,c6_QBL 32,698,168-32,706,021 |
RefSeq DNA sequence:- NT_113891.1 NT_113896.1 NC_000006.10 NT_007592.14
| Proteins
for HLA-DQB1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: HB21_HUMAN, P01918 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DQ(1) beta chain precursor Size: 261 amino acids; 29733 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Caution: PubMed:6954511 have called the protein an HLA-DR antigen-like beta-chain
PDB structure from  and Proteopedia  :1NBN (3D)
1S9V (3D)
Secondary accessions: B0S7Y7 O19708 O19724 O78221 P01917UniProtKB/Swiss-Prot: HB22_HUMAN, P01919 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DQ(W1.1) beta chain precursor Size: 261 amino acids; 29748 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)UniProtKB/Swiss-Prot: HB23_HUMAN, P05537 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DQ(W3) beta chain precursor Size: 261 amino acids; 29780 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)UniProtKB/Swiss-Prot: HB24_HUMAN, P01920 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DQ(3) beta chain precursor Size: 261 amino acids; 29870 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
PDB structure from and Proteopedia :1JK8 (3D)
2NNA (3D)
UniProtKB/Swiss-Prot: HB25_HUMAN, P03992 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor Size: 261 amino acids; 29791 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
PDB structures from and Proteopedia :1UVQ (3D)
Secondary accessions: O19713 O78223 Q29966 Q30082 Q30089 Q30095REFSEQ proteins: NP_002114.3
ENSEMBL proteins: ENSP00000382018 ENSP00000335243 ENSP00000382032 ENSP00000382025 ENSP00000382029 ENSP00000382034 ENSP00000364080 ENSP00000382038
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for HLA-DQB1:
Assays for HLA-DQB1: | Protein
Domains/
Families
for HLA-DQB1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P01918
- Graphical View of Domain Structure for InterPro Entry P01919
- Graphical View of Domain Structure for InterPro Entry P05537
- Graphical View of Domain Structure for InterPro Entry P01920
- Graphical View of Domain Structure for InterPro Entry P03992
ProtoNet protein and cluster: P01918 2 Blocks protein families: IPB000353 Class II histocompatibility antigen IPB003597 Immunoglobulin C-type
UniProtKB/Swiss-Prot: HB21_HUMAN, P01918Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: HB22_HUMAN, P01919Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: HB23_HUMAN, P05537Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: HB24_HUMAN, P01920Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: HB25_HUMAN, P03992Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain | Gene Function
for HLA-DQB1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002123
 Applied Biosystems Silencer® siRNAs for HLA-DQB1
 Sigma-Aldrich siRNA for HLA-DQB1
Sigma-Aldrich shRNA for HLA-DQB1
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_002123
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002123
untagged cDNA clones in CMV expression vector (see all 2): BC012106
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_002123
Genatlas biochemistry entry for HLA-DQB1:HLA-DQ,beta chain15 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for H2-Ab1):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0032395 | MHC class II receptor activity |
NAS | 2998758 |
About this table | Pathways & Interactions
for HLA-DQB1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for HLA-DQB1 (Your Favorite Gene powered by Ingenuity)
Gene Network CentralTM Interacting Genes and Proteins Network for HLA-DQB1
5/40 Interacting proteins for HLA-DQB1 (ENSP000003640803 P019202) via UniProtKB, MINT, and/or STRING (see all 40
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
IEA | -- | | GO:0006955 | immune response |
NAS | 2998758 |
About this table
|
Drugs & Compounds
for HLA-DQB1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for HLA-DQB1
8  Novoseek chemical compound relationships for HLA-DQB1 gene
About this table
|
Transcripts
for HLA-DQB1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002123
Sigma-Aldrich siRNA for HLA-DQB1
Sigma-Aldrich shRNA for HLA-DQB1
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_002123 REFSEQ mRNAs for HLA-DQB1 gene: NM_002123.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002123
OriGene GFP tagged cDNA clone in CMV expression vector: NM_002123
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002123
untagged cDNA clones in CMV expression vector (see all 2): BC012106
Additional cDNA sequence: AB209638.1 M13279.1 M14189.1 M17204.1 M17206.1 M19239.1 M22549.1 V00529.1 24/36 DOTS entries (see all 36
): DT.87078313 DT.92404855 DT.92443956 DT.121314811 DT.87078525 DT.40250885 DT.121314743 DT.100745675 DT.121314508 DT.100824965 DT.121314570 DT.70102156 DT.121314703 DT.85104317 DT.92443957 DT.121314679 DT.121314712 DT.121314578 DT.121314517 DT.121314784 DT.121632200 DT.95274661 DT.75148240 DT.95224644 24/111 AceView cDNA sequences (see all 111
):BU626464 BM008135 BQ012862 M17207 M25327 R19164 BE501332 T29121 CB241087 BU147009 AI597836 M22550 L34105 BM982718 M20432 AA694128 BG759927 AI583173 BQ706217 CA748781 BG686183 BQ004625 BI764056 BE645509
 highest scoring ESTs for HLA-DQB1:AW663173 BF334673 BF663995 BG686183 BG686925 BG759927 BI518821 BI764056 BI907138 BI909533 Unigene Clusters for HLA-DQB1: Major histocompatibility complex, class II, DQ beta 1 Hs.409934 [show with all ESTs], Hs.713773 [show with all ESTs]Unigene Representative Sequences: AK097297, AB209638
GeneLoc Exon Structure
8 Ensembl transcripts including schematic representations: ENST00000399065
ENST00000334399
ENST00000399082
ENST00000399074
ENST00000399079
ENST00000399084
ENST00000374943
ENST00000399088
|
Expression
for HLA-DQB1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HLA-DQB1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HLA-DQB1
1 / 2 / 3 22 probe-sets matching HLA-DQB1 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene clusters: Hs.409934 Hs.713773
Expression variation in blood from EXPOLDB for HLA-DQB1 |
Orthologs
for HLA-DQB1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HLA-DQB1 gene from 2 species
About this table Species with no ortholog for HLA-DQB1
ENSEMBL Gene Tree for HLA-DQB1 | Paralogs
for HLA-DQB1(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for HLA-DQB1 gene
- HLA-DQB22 HLA-DRB52 HLA-DOB2 HLA-DPB12 ENSG000001961262
|
SNPs/Variants
for HLA-DQB1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for HLA-DQB1 (up to first 250kb)
|
Disorders & Mutations
for HLA-DQB1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604305 disorders: 123400 126200 212750 10/34 Novoseek disease relationships for HLA-DQB1 gene (see all 34
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| diabetes mellitus insulin-dependent |
73.03 |
23 |
9820603 (2), 8929711 (2), 15336779 (1), 1728861 (1) (see all 20) |
| genetic susceptibility |
70.33 |
12 |
15256073 (1), 17126830 (1), 18552411 (1), 10053014 (1) (see all 10) |
| autoimmune diseases |
51.27 |
2 |
1520483 (1), 7608264 (1) |
| autoimmunity |
49.99 |
1 |
11240447 (1) |
| celiac disease |
42.89 |
3 |
1919044 (2), 11929591 (1) |
| autoimmune response |
39.65 |
2 |
7690776 (2) |
| iga deficiency |
38.56 |
2 |
1438261 (1), 1520483 (1) |
| dermatitis herpetiformis |
37.05 |
3 |
1919044 (3) |
| multiple sclerosis |
35.52 |
2 |
2001977 (1), 8442703 (1) |
| hepatitis autoimmune |
35.18 |
2 |
7858109 (1), 2175292 (1) |
About this table
GeneTests: HLA-DQB1
Celiac Disease
Human Gene Mutation Database: HLA-DQB1
Genetic Association Database: HLA-DQB1
Human Genome Epidemiology Navigator: HLA-DQB1 (879 documents)
|
Medical News
for HLA-DQB1(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications
for HLA-DQB1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/1116 PubMed articles for HLA-DQB1 gene (see all 1116
):- Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM). (PubMed id 8929711)1, 3, 4 Yasunaga S.... Sasazuki T. (1996)
- HLA-DRB1 and HLA-DQB1 polymorphisms in Pacific Islands populations. (PubMed id 12144623)1, 3, 6 Velickovic Z.M....Carter J.M. (2002)
- Association of HLA-DRB1, DQB1 alleles with chronic urticaria. (PubMed id 16201295)1, 3, 6 Chen J....Xiong P. (2005)
- HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China. (PubMed id 12139680)1, 3, 6 Gao X.H....Wojnarowska F. (2002)
- [Analysis of HLA-DQB1 polymorphism by PCR-SSO in Yichu of Yunnan Province] (PubMed id 11233253)1, 3, 6 Chen W.M....Xu A.L. (2001)
- [HLA DQB1 genotyping in latent autoimmune diabetes of adults (LADA)] (PubMed id 16042135)1, 3, 6 Caputo M....Frechtel G.D. (2005)
- [Relationship between HLA-DQA1, -DQB1 genes polymorphism and susceptilibity to bronchial asthma among Northern Hans] (PubMed id 11953202)1, 3, 6 Gao J....Liu Y. (2002)
- The distribution of DQ genes in the Saharawi population provides only a partial explanation for the high celiac disease prevalence. (PubMed id 11929591)1, 3, 6 Catassi C....Cucca F. (2001)
- Immune related genetic polymorphisms and schizophrenia among the Chinese. (PubMed id 11423178)1, 3, 6 Chowdari K.V....Nimgaonkar V.L. (2001)
- MHC class II, tumour necrosis factor alpha, and lymphotoxin alpha gene haplotype associations with serological subsets of systemic lupus erythematosus. (PubMed id 16107511)1, 3, 6 McHugh N.J....Welsh K. (2006)
|
Search for HLA-DQB1
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HLA-DQB1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HLA-DQB1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HLA-DQB1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| SHMPD | http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HLA-DQB1 | | GeneReviews | http://www.genetests.org/query?gene=HLA-DQB1 | | GeneReviews | http://www.genetests.org/query?gene=HLA-DQB1 | | GeneReviews | http://www.genetests.org/query?gene=HLA-DQB1 | | SHMPD | http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HLA-DQB1 | | GeneReviews | http://www.genetests.org/query?gene=HLA-DQB1 |
|
| | | About This Section
| --
| Services
for HLA-DQB1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for HLA-DQB1:
|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|
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