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Aliases for HLA-DQB1 Gene

Aliases for HLA-DQB1 Gene

  • Major Histocompatibility Complex, Class II, DQ Beta 1 2 3 5
  • MHC Class II Antigen DQB1 3 4
  • HLA-DQB 3 4
  • HLA Class II Histocompatibility Antigen, DQ Beta 1 Chain 3
  • MHC Class II HLA-DQ Beta Glycoprotein 3
  • MHC Class II Antigen HLA-DQ-Beta-1 3
  • MHC Class II DQ Beta Chain 3
  • CELIAC1 3
  • IDDM1 3

External Ids for HLA-DQB1 Gene

Previous HGNC Symbols for HLA-DQB1 Gene

  • HLA-DQB

Previous GeneCards Identifiers for HLA-DQB1 Gene

  • GC06U990046
  • GC06M032623
  • GC06M032398
  • GC06M032675
  • GC06M032678
  • GC06M032727
  • GC06M032735

Summaries for HLA-DQB1 Gene

Entrez Gene Summary for HLA-DQB1 Gene

  • HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

GeneCards Summary for HLA-DQB1 Gene

HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1) is a Protein Coding gene. Diseases associated with HLA-DQB1 include Celiac Disease and Multiple Sclerosis, Disease Progression, Modifier Of. Among its related pathways are Hematopoietic cell lineage and Allograft rejection. GO annotations related to this gene include peptide antigen binding and MHC class II receptor activity. An important paralog of this gene is HLA-DQB2.

UniProtKB/Swiss-Prot for HLA-DQB1 Gene

  • Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Gene Wiki entry for HLA-DQB1 Gene

Additional gene information for HLA-DQB1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-DQB1 Gene

Genomics for HLA-DQB1 Gene

Regulatory Elements for HLA-DQB1 Gene

Enhancers for HLA-DQB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H032633 1.8 FANTOM5 Ensembl ENCODE dbSUPER 86.7 +31.4 31379 7.2 HDGF FEZF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF416 ZNF143 ATF7 RUNX3 HLA-DQA1 HLA-DQB1 HLA-DQA2 HLA-DRB1 HLA-DQB2 HLA-DRB5 PPT2 HLA-DRB6 HCG25 VPS52
GH06H032689 1.4 FANTOM5 ENCODE dbSUPER 95.4 -22.3 -22316 2.4 HDGF CTCF IRF3 BACH1 BATF RELA RFX5 POLR2A NFYB EED HLA-DQB1 HLA-DRB6 HLA-DOB HLA-DQA2 CYP21A1P HLA-DQA1 HLA-DRB5 HLA-DQB2 HLA-DOA HLA-DQB1-AS1
GH06H032685 1.4 FANTOM5 ENCODE dbSUPER 76.6 -17.7 -17734 1.8 TBL1XR1 EBF1 BATF RELA RFX5 EED ATF7 ETV6 RUNX3 IKZF2 HLA-DQB1 HLA-DQA2 HLA-DQB1-AS1 CYP21A1P HLA-DQA1 HLA-DRB6 HLA-DOB HLA-DOA HLA-DPB1 HLA-DRB5
GH06H032664 1.1 ENCODE dbSUPER 84.5 +1.3 1306 5 PKNOX1 ZNF2 RFX5 SCRT2 ZNF143 ATF7 RUNX3 CREM IKZF2 SMARCA5 HLA-DQA1 HLA-DQB1 HLA-DQB1-AS1 HLA-DQB2 HLA-DRB1 HLA-DQA2 HLA-DRB6 C4A LY6G5B VPS52
GH06H032621 1.9 FANTOM5 Ensembl ENCODE dbSUPER 44.6 +43.2 43161 8.3 PKNOX1 FEZF1 ZNF2 ZNF143 ZNF207 ATF7 RUNX3 JUNB ZNF592 ZNF610 HLA-DRB1 HLA-DQA2 HLA-DRB6 HLA-DQB1 HLA-DRB5 HLA-DQB2 HLA-DQA1 CYP21A1P BRD2 HLA-DQB1-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HLA-DQB1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for HLA-DQB1 Gene

Genomic Locations for HLA-DQB1 Gene
chr6:32,659,464-32,668,383
(GRCh38/hg38)
Size:
8,920 bases
Orientation:
Minus strand
chr6:32,627,244-32,636,160
(GRCh37/hg19)

Genomic View for HLA-DQB1 Gene

Genes around HLA-DQB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-DQB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-DQB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-DQB1 Gene

  • Protein details for HLA-DQB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01920-DQB1_HUMAN
    Recommended name:
    HLA class II histocompatibility antigen, DQ beta 1 chain
    Protein Accession:
    P01920
    Secondary Accessions:
    • A1KR27
    • A2RPH3
    • A4Q9R4
    • A4USG2
    • A4USG5
    • A6N8I7
    • A9YQA0
    • B0S7Y7
    • B1A0K6
    • B1GXI3
    • B3VLT3
    • B5BLN7
    • B7VU69
    • C0MQ34
    • C0MQ35
    • C8ZL52
    • C8ZLJ8
    • C8ZLJ9
    • C9DRQ3
    • O19708
    • O19713
    • O19724
    • O62861
    • O78046
    • O78221
    • O78223
    • O98034
    • O98201
    • P01917
    • P01918
    • P01919
    • P03992
    • P05537
    • P79482
    • P79526
    • P79544
    • P79551
    • Q08GC8
    • Q09035
    • Q0E4V9
    • Q1M312
    • Q29731
    • Q29877
    • Q29884
    • Q29915
    • Q29966
    • Q2P9N3
    • Q2QK85
    • Q30061
    • Q30075
    • Q30076
    • Q30080
    • Q30081
    • Q30082
    • Q30083
    • Q30084
    • Q30089
    • Q30095
    • Q31633
    • Q38I47
    • Q45UE3
    • Q4QZB5
    • Q53I44
    • Q564J6
    • Q5G841
    • Q5ISH1
    • Q5ISH3
    • Q5W1E1
    • Q5Y7G8
    • Q643R4
    • Q6B9X1
    • Q70VH8
    • Q7YP69
    • Q8HWH0
    • Q8MH58
    • Q8SNB4
    • Q8SND1
    • Q8SP70
    • Q8WMA3
    • Q9BD17
    • Q9MYH2
    • Q9TPA9
    • Q9XRY6
    • Q9XRY7
    • Q9XRZ2

    Protein attributes for HLA-DQB1 Gene

    Size:
    261 amino acids
    Molecular mass:
    29991 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.
    SequenceCaution:
    • Sequence=AAC64403.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAJ57391.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HLA-DQB1 Gene

neXtProt entry for HLA-DQB1 Gene

Post-translational modifications for HLA-DQB1 Gene

  • Glycosylation at isoforms=51
  • Modification sites at PhosphoSitePlus

Other Protein References for HLA-DQB1 Gene

No data available for DME Specific Peptides for HLA-DQB1 Gene

Domains & Families for HLA-DQB1 Gene

Gene Families for HLA-DQB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

P01920

UniProtKB/Swiss-Prot:

DQB1_HUMAN :
  • Belongs to the MHC class II family.
Family:
  • Belongs to the MHC class II family.
genes like me logo Genes that share domains with HLA-DQB1: view

Function for HLA-DQB1 Gene

Molecular function for HLA-DQB1 Gene

GENATLAS Biochemistry:
HLA-DQ,beta chain
UniProtKB/Swiss-Prot Function:
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Phenotypes From GWAS Catalog for HLA-DQB1 Gene

Gene Ontology (GO) - Molecular Function for HLA-DQB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11376336
GO:0032395 MHC class II receptor activity NAS 2998758
GO:0042605 peptide antigen binding ISS 20356827
genes like me logo Genes that share ontologies with HLA-DQB1: view
genes like me logo Genes that share phenotypes with HLA-DQB1: view

Human Phenotype Ontology for HLA-DQB1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HLA-DQB1 Gene

MGI Knock Outs for HLA-DQB1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for HLA-DQB1 Gene

Localization for HLA-DQB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-DQB1 Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLA-DQB1 gene
Compartment Confidence
plasma membrane 4
extracellular 2
endoplasmic reticulum 2
lysosome 2
endosome 2
mitochondrion 1
nucleus 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HLA-DQB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005765 lysosomal membrane TAS --
GO:0005886 plasma membrane TAS --
GO:0010008 endosome membrane IEA --
GO:0012507 ER to Golgi transport vesicle membrane TAS --
genes like me logo Genes that share ontologies with HLA-DQB1: view

Pathways & Interactions for HLA-DQB1 Gene

genes like me logo Genes that share pathways with HLA-DQB1: view

Gene Ontology (GO) - Biological Process for HLA-DQB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response IDA 17050030
GO:0002455 humoral immune response mediated by circulating immunoglobulin IDA 17050030
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA --
GO:0006955 immune response IEA,NAS 2998758
GO:0019882 antigen processing and presentation IEA --
genes like me logo Genes that share ontologies with HLA-DQB1: view

No data available for SIGNOR curated interactions for HLA-DQB1 Gene

Drugs & Compounds for HLA-DQB1 Gene

(12) Drugs for HLA-DQB1 Gene - From: DrugBank, PharmGKB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Insulin Pork Approved Pharma Target 0
Acetaminophen Approved Pharma 973
Allopurinol Approved Pharma 149
Amoxicillin Approved, Vet_approved Pharma 487
Clavulanate Approved, Vet_approved Pharma 0

(7) Additional Compounds for HLA-DQB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HLA-DQB1: view

Transcripts for HLA-DQB1 Gene

Unigene Clusters for HLA-DQB1 Gene

Major histocompatibility complex, class II, DQ beta 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-DQB1 Gene

No ASD Table

Relevant External Links for HLA-DQB1 Gene

GeneLoc Exon Structure for
HLA-DQB1
ECgene alternative splicing isoforms for
HLA-DQB1

Expression for HLA-DQB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HLA-DQB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-DQB1 Gene

This gene is overexpressed in Whole Blood (x5.6), Spleen (x4.5), and Lung (x4.2).

Protein differential expression in normal tissues from HIPED for HLA-DQB1 Gene

This gene is overexpressed in Nasal epithelium (38.3), Peripheral blood mononuclear cells (8.3), and Skin (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HLA-DQB1 Gene



Protein tissue co-expression partners for HLA-DQB1 Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for HLA-DQB1 Gene:

Hs.409934

Evidence on tissue expression from TISSUES for HLA-DQB1 Gene

  • Lung(3.9)
  • Blood(3.4)
  • Spleen(2.9)
  • Nervous system(2.7)
  • Intestine(2.2)
  • Lymph node(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-DQB1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • cranial nerve
  • ear
  • eye
  • head
  • jaw
  • lacrimal apparatus
  • mandible
  • maxilla
  • mouth
  • neck
  • pharynx
  • salivary gland
  • skull
  • tongue
Thorax:
  • chest wall
  • clavicle
  • esophagus
  • heart
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • kidney
  • pancreas
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with HLA-DQB1: view

No data available for mRNA Expression by UniProt/SwissProt for HLA-DQB1 Gene

Orthologs for HLA-DQB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HLA-DQB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100616520 33
  • 94.83 (n)
PATR-DQB1 34
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 91 (a)
ManyToMany
BLA-DQB 33
  • 86.3 (n)
BOLA-DQB 34 34
  • 82 (a)
ManyToMany
BOLA-DIB 34
  • 63 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia DLA-DQB1 33
  • 85.25 (n)
DLA-DQBC1 34
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RT1-Bb 33
  • 83.26 (n)
mouse
(Mus musculus)
Mammalia H2-Ab1 16 34 33
  • 79.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 72 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 59 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hla-drb1 33
  • 60.81 (n)
Species where no ortholog for HLA-DQB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HLA-DQB1 Gene

ENSEMBL:
Gene Tree for HLA-DQB1 (if available)
TreeFam:
Gene Tree for HLA-DQB1 (if available)

Paralogs for HLA-DQB1 Gene

(220) SIMAP similar genes for HLA-DQB1 Gene using alignment to 830 proteins: