HLA-DQA2 Gene
protein-coding GIFtS: 49
GCID: GC06P032709
|
|
major histocompatibility complex, class II, DQ alpha 2
(Previous symbol: HLA-DXA)
| |
Aliases
for HLA-DQA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Major Histocompatibility Complex, Class II, DQ Alpha 21 2 | | MHC Class II DQA22 3 | | HLA-DXA1 2 3 5 | | DX-ALPHA2 | | DX Alpha Chain2 3 | | HLA Class II Histocompatibility Antigen, DQ Alpha 2 Chain2 | | HLA Class II Histocompatibility Antigen, DQ(6) Alpha Chain2 3 | | HLA-DQA13 |
Export aliases for HLA-DQA2 gene to outside databasesPrevious GC identifers: GC06P032711 GC06P032479 GC06P032756 GC06P032817 |
Summaries
for HLA-DQA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HLA-DQA2:
This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II betachain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class IImolecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed inantigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides onthe cell surface to be recognized by CD4 T-cells. (provided by RefSeq, Jun 2010)
UniProtKB/Swiss-Prot: DQA2_HUMAN, P01906Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) andpresents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptidesof 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteinsthat access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenousantigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, andfor this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on theirway to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomalcompartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also asource of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In additionto APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents anantigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in theER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigenprocessing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving asmall fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DMvia direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II moleculesuntil primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transportedto the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated byHLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in theregulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis andefficient peptide loading
Gene Wiki entry for HLA-DQA2
|
Genomic Views
for HLA-DQA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HLA-DQA2 gene promoter:
c-Fos GR USF1 AP-1 Pbx1a HTF USF-1 Zic1 GR-alpha c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for HLA-DQA2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DQA2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.3HLA-DQA2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P032709: view genomic region
(about GC identifiers)
Start:
|
32,709,119 bp from pter |
End:
|
32,714,992 bp from pter |
Size:
|
5,874 bases |
Orientation:
|
plus strand |
6/7 alternative locations (see all 7):
| Chr6+,ALT_REF_LOCI_5 32,657,768-32,663,270 | Chr6+,ALT_REF_LOCI_6 32,637,805-32,678,942 | Chr6+,ALT_REF_LOCI_4 32,785,980-32,791,492 | | Chr6+,ALT_REF_LOCI_3 32,688,301-32,704,870 | Chr6+,ALT_REF_LOCI_2 32,632,816-32,677,550 | Chr6+,ALT_REF_LOCI_1 32,694,039-32,707,845 | |
|
Proteins
for HLA-DQA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DQA2_HUMAN, P01906 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DQ alpha 2 chain precursor Size: 255 amino acids; 28033 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmicreticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariantchain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoessequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHCclass II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding ofantigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-passtype I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosomemembrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHCclass II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches thecell membrane for antigen presentation
Caution: There is some controversy on whether this gene is really expressed or not
Secondary accessions: A2BF37 B0V0E7 O19789 Q5SQ94 Q5SR04Explore the universe of human proteins at neXtProt for HLA-DQA2: NX_P01906
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P01906
HLA-DQA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_064440.1
ENSEMBL proteins: ENSP00000364076 Reactome Protein details: P01906
Human Recombinant Protein Products for HLA-DQA2:
Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14): About this table
HLA-DQA2 for ontologies About GeneDecksing
HLA-DQA2 Antibody Products:
Assay Products for HLA-DQA2: |
Protein
Domains /
Families
for HLA-DQA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HLA-DQA2 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P01906ProtoNet protein and cluster: P01906 2 Blocks protein families: IPB001003 MHC Class II alpha chain IPB003597 Immunoglobulin C-type
UniProtKB/Swiss-Prot: DQA2_HUMAN, P01906Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain |
Function
for HLA-DQA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DQA2_HUMAN, P01906Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) andpresents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptidesof 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteinsthat access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenousantigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, andfor this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on theirway to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomalcompartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also asource of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In additionto APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents anantigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in theER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigenprocessing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving asmall fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DMvia direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II moleculesuntil primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transportedto the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated byHLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in theregulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis andefficient peptide loading Genatlas biochemistry entry for HLA-DQA2:HLA-DQ,alpha chain-related,not known to be expressed
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0032395 | MHC class II receptor activity |
NAS | 3036828 |
HLA-DQA2 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DQA2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DQA2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HLA-DQA2 (NM_020056) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HLA-DQA2 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HLA-DQA2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DQA2 |
|
Pathways & Interactions
for HLA-DQA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Allograft rejection | | | 2 | Transport of MHC II:Ii complex along Golgi to TGN | | | 3 | Translocation of ZAP-70 to Immunological synapse | | | 4 | ICos-ICosL Pathway in T-Helper Cell | | | 5 | PKC-Theta Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HLA-DQA2 (see all 12)
5/6  GeneGo (Thomson Reuters) Pathways for HLA-DQA2 (see all 6)
5/20 
Reactome Pathways for HLA-DQA2 (see all 20)
5/17 
Kegg Pathways (Kegg details for HLA-DQA2) (see all 17):
HLA-DQA2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HLA-DQA2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/44 Interacting proteins for HLA-DQA2 (P019063 ENSP000003640764) via UniProtKB, MINT, STRING, and/or I2D (see all 44)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
-- | -- | | GO:0006955 | immune response |
NAS | 3036828 | | GO:0019221 | cytokine-mediated signaling pathway |
TAS | -- | | GO:0019882 | antigen processing and presentation |
-- | -- | | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
TAS | -- |
HLA-DQA2 for ontologies About GeneDecksing
|
Drugs & Compounds
for HLA-DQA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HLA-DQA2
1 DrugBank Compound for HLA-DQA2 About this table
Search CenterWatch for drugs/clinical trials and news about HLA-DQA2 / DQA2
|
Transcripts
for HLA-DQA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HLA-DQA2 gene: NM_020056.4 1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000374940(uc003obx.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DQA2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DQA2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HLA-DQA2 (NM_020056) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HLA-DQA2 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HLA-DQA2 |
24/548 AceView cDNA sequences (see all 548): CA309331 AF533930 BV176870 BV177914 AU076978 BM694667 L46875 L34083 BU680454 CA306036 BG756170 AW388115 BV177094 BU617246 BV177637 NM_002122 BV177276 AW388120 BV177061 BV176869 CK820437 AW388107 BV177713 CD369275
GeneLoc Exon Structure
|
Expression
for HLA-DQA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HLA-DQA2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HLA-DQA2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HLA-DQA2
UniProtKB/Swiss-Prot: DQA2_HUMAN, P01906Tissue specificity: Expressed at low levels at the surface of B lymphoblastoid cells
SABiosciences Custom PCR Arrays for HLA-DQA2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-DQA2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HLA-DQA2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DQA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DQA2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DQA2 |
Orthologs
for HLA-DQA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HLA-DQA2 gene from 2/6 species (see all 6) About this table
ENSEMBL Gene Tree for HLA-DQA2 (if available)
TreeFam Gene Tree for HLA-DQA2 (if available) |
Paralogs
for HLA-DQA2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HLA-DQA2 gene
- HLA-DRB52 HLA-DQA12 HLA-DPA12 HLA-DQB12 HLA-DRA2 HLA-DOB2 HLA-DRB12 HLA-DMA2
- HLA-DQB22 ENSG000002489932 HLA-DOA2 HLA-DMB2 HLA-DPB12
18/35 SIMAP similar genes for HLA-DQA2 using alignment to 5 protein entries: DQA2_HUMAN (see all proteins)
(see all similar genes):HLA-DQA1 HLA-DQA1/DRA DQA1-0103 DQ-A1 HLA-DPA1 HLA-DRA1
HLA-DOA HLA-DRA HLA-DMA HLA-DQB1*06x HLA-DPB1 HLA-DQB2
HLA-DP HLA-DRB5 HLA-DRB3 HLA-DQB1 HLA-DRB1 B2M
HLA-DQA2 for paralogs About GeneDecksing
|
Genomic Variants
for HLA-DQA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HLA-DQA2 (32709119 - 32714992 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for HLA-DQA2
7 CNVs: 7570 69417 62501 69435 69424 64476 69419
Locus Specific Mutation Databases (LSDB): HLA-DQA2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-DQA2 |
|
Disorders
/ Diseases
for HLA-DQA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HLA-DQA2 for disorders About GeneDecksing
OMIM gene information: 613503
OMIM disorders: --
20/24  diseases for HLA-DQA2 (see all 24): About MalaCardsgraft versus host disease childhood type dermatomyositis alopecia areata systemic lupus erythematosus
lupus erythematosus rheumatoid arthritis alopecia autoimmune thyroiditis
diabetes mellitus celiac disease dermatomyositis toxoplasmosis
leishmaniasis hepatitis b arthritis narcolepsy
osteoarthritis influenza thyroiditis asthma
2 diseases from the University of Copenhagen DISEASES database for HLA-DQA2:Celiac disease Diabetes mellitus Human Genome Epidemiology (HuGE) Navigator: HLA-DQA2 (10 documents)
Export disorders for HLA-DQA2 gene to outside databases
|
Publications
for HLA-DQA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HLA-DQA2 gene, integrated from 9 sources (see all 90):
(articles sorted by number of sources associating them with HLA-DQA2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells. (PubMed id 9036956)1, 2 Rudy G.B. and Lew A.M. (1997)
- Limited polymorphism of the HLA-DQA2 promoter and identification of a variant octamer. (PubMed id 8026991)1, 2 Rudy G. and Lew A.M. (1994)
- Ancient roots for polymorphism at the HLA-DQ alpha locus in primates. (PubMed id 2513578)1, 2 Gyllensten U.B. and Erlich H.A. (1989)
- Structure and expression of HLA-DQ alpha and -DX alpha genes: interallelic alternate splicing of the HLA-DQ alpha gene and functional splicing of the HLA-DQ alpha gene using a retroviral vector. (PubMed id 3610256)1, 2 Auffray C.... Strominger J.L. (1987)
- Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes. (PubMed id 3036828)1, 2 Jonsson A.-K.... Rask L. (1987)
- Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes. (PubMed id 6584734)1, 2 Auffray C....Strominger J.L. (1984)
- Novel associations for hypothyroidism include known au toimmune risk loci. (PubMed id 22493691)1 Eriksson N....Do C.B. (2012)
- HIV-1 Gag-virus-like particles induce natural killer c ell immune responses via activation and maturation of dendritic cells. (PubMed id 21778700)1 Chang M.O....Takaku H. (2012)
- HLA-DQA2 and HLA-DQB2 genes are specifically expressed in human Langerhans cells and encode a new HLA class II molecule. (PubMed id 22407913)1 Lenormand C....Tourne S. (2012)
- Stratifying type 2 diabetes cases by BMI identifies ge netic risk variants in LAMA1 and enrichment for risk variants in lean compared t o obese cases. (PubMed id 22693455)1 Perry J.R....Cauchi S. (2012)
|
External Searches for HLA-DQA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HLA-DQA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HLA-DQA2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HLA-DQA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HLA-DQA2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HLA-DQA2 gene:
Search GeneIP for patents involving HLA-DQA2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HLA-DQA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HLA-DQA2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLA-DQA2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-DQA2 | | | OriGene Protein Over-expression Lysate for HLA-DQA2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HLA-DQA2 | | OriGene 3'-UTR Clone for HLA-DQA2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DQA2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DQA2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HLA-DQA2 | | OriGene Custom Protein Services for HLA-DQA2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HLA-DQA2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-DQA2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DQA2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-DQA2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DQA2 | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DQA2 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DQA2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for HLA-DQA2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat HLA-DQA2 |
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