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Aliases &
Descriptions
for HLA-DQA1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| CD 2 | | CELIAC1 1, 2, 5 | | DC-alpha 3 | | DQ-A1 2 | | FLJ27088 2 | | FLJ27328 2 | | GSE 2 | | HLA-DCA 3 | | HLA-DQA 2 | | HLA-DQA1*05011 3 | | HLA-DQA1*0502 3 | | MGC149527 2 | | OTTHUMP00000029141 2 | | OTTHUMP00000176885 2 | | OTTHUMP00000178551 2 | | OTTHUMP00000178552 2 |
| | | Descriptions |
|---|
| DC-1 alpha chain 3 | | DQ-DRW9 alpha chain 3 | | Gluten-sensitive enteropathy (celiac disease) 2 | | MHC HLA-DQ alpha 2 | | MHC class II HLA-D alpha glycoprotein 2 | | MHC class II HLA-DQ-alpha-1 2 | | MHC class II antigen 2 | | MHC class II surface glycoprotein 2 | | leucocyte antigen DQA1 2 | | leukocyte antigen alpha chain 2 | | major histocompatibility complex, class II, DQ alpha 1 2 |
|
| |
Search outside databases for aliases for HLA-DQA1 genePrevious GC identifers: GC06Pd32632 GC06P032375 |
Summaries
for HLA-DQA1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for HLA-DQA1:
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer
consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a
central role in the immune system by presenting peptides derived from extracellular proteins.
Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells,
macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes
the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the
transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the
beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up
to four different molecules. Typing for these polymorphisms is routinely done for bone marrow
transplantation. [provided by RefSeq]
Gene Wiki entry for HLA-DQA1 (Major_histocompatibility_complex%2C_class_II%2C_DQ_alpha_1) |
Genomic Location
for HLA-DQA1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the HLA-DQA1 gene 
Entrez Gene cytogenetic band: 6p21.3 HGNC cytogenetic band: 6p21.3HLA-DQA1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P032649:
(about GC identifiers)
Start:
|
32,713,161 bp from pter |
End:
|
32,719,407 bp from pter |
Size:
|
6,247 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NT_113891.1 NT_113896.1 NC_000006.10 NT_007592.14
| Proteins
for HLA-DQA1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: HA22_HUMAN, P04226 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DQ(2) alpha chain precursor Size: 254 amino acids; 27937 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: Q6ICU6UniProtKB/Swiss-Prot: HA23_HUMAN, P01909 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DQ(3) alpha chain precursor Size: 254 amino acids; 27805 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
PDB structure from  and Proteopedia  :1NBN (3D)
1S9V (3D)
Secondary accessions: O19630 Q30101 Q9UM31UniProtKB/Swiss-Prot: HA24_HUMAN, P04225 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DQ(4) alpha chain precursor Size: 232 amino acids; 25808 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
PDB structures from and Proteopedia :1JK8 (3D)
UniProtKB/Swiss-Prot: HA25_HUMAN, P01907 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DQ(5) alpha chain precursor Size: 255 amino acids; 28000 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
PDB structures from and Proteopedia :1UVQ (3D)
Secondary accessions: Q06751 Q29994 Q30086 Q5Y7D5UniProtKB/Swiss-Prot: HA27_HUMAN, P05536 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DQ(W3) alpha chain precursor Size: 254 amino acids; 27845 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)REFSEQ proteins: NP_002113.2
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for HLA-DQA1:
Assays for HLA-DQA1: | Protein
Domains/
Families
for HLA-DQA1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P04226
- Graphical View of Domain Structure for InterPro Entry P01909
- Graphical View of Domain Structure for InterPro Entry P04225
- Graphical View of Domain Structure for InterPro Entry P01907
- Graphical View of Domain Structure for InterPro Entry P05536
ProtoNet protein and cluster: P04226 2 Blocks protein families: IPB001003 MHC Class II alpha chain IPB003597 Immunoglobulin C-type
UniProtKB/Swiss-Prot: HA22_HUMAN, P04226Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: HA23_HUMAN, P01909Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: HA24_HUMAN, P04225Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: HA25_HUMAN, P01907Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainUniProtKB/Swiss-Prot: HA27_HUMAN, P05536Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain | Gene Function
for HLA-DQA1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 21): NM_002122
 Applied Biosystems Silencer® siRNAs for HLA-DQA1
 Sigma-Aldrich siRNA for HLA-DQA1
Sigma-Aldrich shRNA for HLA-DQA1
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_002122
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002122
untagged cDNA clone in CMV expression vector: NM_002122
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_002122
Genatlas biochemistry entry for HLA-DQA1:HLA-DQ,alpha chain2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for H2-Aa):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0032395 | MHC class II receptor activity |
TAS | 2300572 |
About this table | Pathways & Interactions
for HLA-DQA1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
3 Sigma-Aldrich "Your Favorite Gene" Pathways for HLA-DQA1 (Your Favorite Gene powered by Ingenuity)
Gene Network CentralTM Interacting Genes and Proteins Network for HLA-DQA1
4 Interacting proteins for HLA-DQA1 (P042262 P042252, 2) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
IEA | -- | | GO:0006955 | immune response |
NAS | 3584986 6415485 |
About this table
|
Drugs & Compounds
for HLA-DQA1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for HLA-DQA1
5  Novoseek chemical compound relationships for HLA-DQA1 gene
About this table
|
Transcripts
for HLA-DQA1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 21): NM_002122
Sigma-Aldrich siRNA for HLA-DQA1
Sigma-Aldrich shRNA for HLA-DQA1
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_002122 REFSEQ mRNAs for HLA-DQA1 gene: NM_002122.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002122
OriGene GFP tagged cDNA clone in CMV expression vector: NM_002122
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002122
untagged cDNA clone in CMV expression vector: NM_002122
Additional cDNA sequence: AF533909.1 AF533910.1 AF533911.1 AF533915.1 AF533916.1 AF533917.1 AF533918.1 AF533919.1 AF533920.1 AF533921.1 AF533922.1 AF533923.1 AF533924.1 AF533925.1 AF533926.1 AF533927.1 AF533928.1 AF533932.1 AF533933.1 AF533934.1 AF533935.1 24/38 DOTS entries (see all 38
): DT.91771249 DT.95134359 DT.91837951 DT.100794755 DT.121314551 DT.121314783 DT.91771252 DT.100031261 DT.97789469 DT.317668 DT.121314757 DT.97855223 DT.121314720 DT.121314709 DT.415581 DT.100031266 DT.100031265 DT.91771251 DT.100031262 DT.121314678 DT.101956786 DT.91771262 DT.100031264 DT.121314796 24/548 AceView cDNA sequences (see all 548
):AF533930 NM_002122 CA309331 L34083 BV177061 CK820437 BV176870 AW388107 AW388120 BV177094 BV177637 AW388115 BU617246 BG756170 L46875 BU680454 BV177914 BV177276 BV177713 BV176869 AU076978 CA306036 BM694667 BV203475
 highest scoring ESTs for HLA-DQA1:AA131654 AA411017 AA419168 AA746256 AA858023 AB209628 AF533895 AF533896 AF533897 AF533901 Unigene Clusters for HLA-DQA1: Major histocompatibility complex, class II, DQ alpha 1 Hs.387679 [show with all ESTs], Hs.706240 [show with all ESTs]Unigene Representative Sequences: AB209628, BQ049081
GeneLoc Exon Structure
|
Expression
for HLA-DQA1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HLA-DQA1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HLA-DQA1
1 / 2 / 3 10 probe-sets matching HLA-DQA1 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene clusters: Hs.387679 Hs.706240
Expression variation in blood from EXPOLDB for HLA-DQA1 |
Orthologs
for HLA-DQA1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HLA-DQA1 gene from 5 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
DLA-DQA11 |
-- |
major histocompatibility complex, class II, DQ alpha more |
86.67(n)
80.78(a) |
474861 NM_001011726.1 NP_001011726.1 |
chimpanzee
(Pan troglodytes) |
PATR-DQA11 |
-- |
major histocompatibility complex, class II, DQ alpha more |
94.38(n)
90.98(a) |
471974 XM_527352.2 XP_527352.2 |
cow
(Bos taurus) |
BOLA-DQA11 |
-- |
histocompatibility complex, class II, DQ alpha, type more |
84.58(n)
78.43(a) |
282534 XM_001253887.1 XP_001253888.1 |
rat
(Rattus norvegicus) |
RT1-Ba1 |
-- |
RT1 class II, locus Ba |
80.45(n)
74.41(a) |
309621 NM_001008831.1 NP_001008831.1 |
mouse
(Mus musculus) |
H2-Aa1, 5 |
17 (18.65 cM)5
|
histocompatibility 2, class II antigen A, alpha1, 5 |
80.95(n)1
71.83(a)1 |
149601 NM_010378.21 NP_034508.21
AF0659105 AF0659115 (see all 30) |
About this table Species with no ortholog for HLA-DQA1 | Paralogs
for HLA-DQA1(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
SNPs/Variants
for HLA-DQA1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for HLA-DQA1 (up to first 250kb)
|
Disorders & Mutations
for HLA-DQA1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 146880 disorders: 212750 10/15 Novoseek disease relationships for HLA-DQA1 gene (see all 15
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| diabetes mellitus insulin-dependent |
70.31 |
10 |
9458118 (2), 10697396 (2), 8820406 (1), 7817375 (1) (see all 8) |
| genetic susceptibility |
54.95 |
7 |
10194252 (2), 8820406 (1), 10522814 (1), 15164102 (1) (see all 6) |
| graves disease |
38.56 |
1 |
15558498 (1) |
| autoimmune diseases |
38.02 |
3 |
9209509 (1), 8995182 (1), 7608264 (1) |
| arthritis juvenile rheumatoid |
30.52 |
1 |
7652738 (1) |
| atopy |
27.36 |
11 |
12890388 (4), 11953202 (1) |
| autoimmune thyroid disease |
23.37 |
1 |
9548077 (1) |
| viral hepatitis |
4.16 |
2 |
15231205 (1) |
| tumors |
1.32 |
3 |
12756506 (1), 15077289 (1), 9598907 (1) |
| necrosis |
0.00 |
2 |
15077289 (1), 9598907 (1) |
About this table
GeneTests: HLA-DQA1
Celiac Disease
Human Gene Mutation Database: HLA-DQA1
Genetic Association Database: HLA-DQA1
Human Genome Epidemiology Navigator: HLA-DQA1 (448 documents)
|
Medical News
for HLA-DQA1(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications
for HLA-DQA1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/645 PubMed articles for HLA-DQA1 gene (see all 645
):- Association between HLA-DQA1, -DQB1 gene polymorphisms and susceptibility to asthma in northern Chinese subjects. (PubMed id 12890388)1, 3, 6 Gao J....Liu Y. (2003)
- [Relationship between HLA-DQA1, -DQB1 genes polymorphism and susceptilibity to bronchial asthma among Northern Hans] (PubMed id 11953202)1, 3, 6 Gao J....Liu Y. (2002)
- [Study on the polymorphisme of human leucocyte antigen-DRB1, -DQA1 and -DQB1 alleles in patients with hepatitis B] (PubMed id 15231205)1, 3, 6 Jiang Y.G. and Wang Y.M. (2004)
- Molecular analysis of HLA-DRB1, DQA1, DQB1, DQ promoter polymorphism and extended class I/class II haplotypes in the Seri Indians from Northwest Mexico. (PubMed id 12144622)1, 3, 6 Alaez C....Gorodezky C. (2002)
- [Distribution of HLA DQA1, LDLR, GYPA, HBGG, D7S8, and GC locus alleles in the population of Russia] (PubMed id 12165956)1, 3, 6 Kornienko I.V....Ivanov P.L. (2002)
- [Association of human leukocyte antigen-DQA1 with endometriosis of women in southern China] (PubMed id 11718025)1, 3, 6 Zong L....Pan D. (2001)
- DRB1, DQA1, DQB1 genes in Turkish children with rheumatic fever. (PubMed id 15789899)1, 3, 6 Hallioglu O....Ozer S. (2005)
- DQB1*0602 allele shows a strong association with multiple sclerosis in patients in Malaga, Spain. (PubMed id 15083289)1, 3, 6 Fernandez O....de Ramon E. (2004)
- Susceptibility alleles and haplotypes of human leukocyte antigen DRB1, DQA1, and DQB1 in autoimmune polyglandular syndrome type III in Japanese population. (PubMed id 16254435)1, 3, 6 Hashimoto K....Nakamura T. (2005)
- Association of Helicobacter pylori-related distal gastric cancer with the HLA class II gene DQB10602 and cagA strains in a southern European population. (PubMed id 15691311)1, 3, 6 Quintero E....Salido E. (2005)
|
Search for HLA-DQA1
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HLA-DQA1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HLA-DQA1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HLA-DQA1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| GeneReviews | http://www.genetests.org/query?gene=HLA-DQA1 | | GeneReviews | http://www.genetests.org/query?gene=HLA-DQA1 | | GeneReviews | http://www.genetests.org/query?gene=HLA-DQA1 | | GeneReviews | http://www.genetests.org/query?gene=HLA-DQA1 | | GeneReviews | http://www.genetests.org/query?gene=HLA-DQA1 |
|
| | | About This Section
| --
| Services
for HLA-DQA1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for HLA-DQA1:
|
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|
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