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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLA-DPB2 Gene

pseudogene   GIFtS: 35
GCID: GC06P033080

major histocompatibility complex, class II, DP beta 2 (pseudogene)


(Previous symbol: HLA-DP2B)
 Explore 3 diseases affiliated with
HLA-DPB2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HLA-DPB2    

Aliases
for HLA-DPB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Major Histocompatibility Complex, Class II, DP Beta 2 (Pseudogene)1 2
DP2B1 2
DPB21 2
HLA-DP2B1 2
DPbeta22

External Ids:    HGNC: 49411   Entrez Gene: 31162   Ensembl: ENSG000002245577   

Export aliases for HLA-DPB2 gene to outside databases

Previous GC identifers: GC06U990045 GC06P033127 GC06P033188 GC06P032822


Summaries
for HLA-DPB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for HLA-DPB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLA-DPB2 gene promoter:
         HOXA9   HOXA9B   Elk-1   CBF-C   c-Ets-1   Meis-1b   CBF-B   CBF-A   Meis-1   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HLA-DPB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DPB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

HLA-DPB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-DPB2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P033080:  view genomic region     (about GC identifiers)

Start:
 33,080,228 bp from pter      End:
 33,102,442 bp from pter
Size:
 22,215 bases      Orientation:
 plus strand

6 alternative locations:
Chr6+,ALT_REF_LOCI_1 33,063,595-33,088,553      Chr6+,ALT_REF_LOCI_2 33,002,124-33,057,662      Chr6+,ALT_REF_LOCI_3 33,073,504-33,085,837     
Chr6+,ALT_REF_LOCI_6 33,009,286-33,061,244      Chr6+,ALT_REF_LOCI_4 33,157,500-33,173,812      Chr6+,ALT_REF_LOCI_7 33,150,236-33,166,520     

Proteins
for HLA-DPB2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB: --

Protein Domains /
Families
for HLA-DPB2 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Function
for HLA-DPB2 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:
     Genatlas biochemistry entry for HLA-DPB2:
HLA-DP,beta chain-related pseudogene

miRNA
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Inhib. RNA
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Gene Editing
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In Situ Assay
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1 GenomeRNAi human phenotype for HLA-DPB2:
 Increased HPV18 LCR reporter a 


Pathways & Interactions
for HLA-DPB2 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Immune response_NFAT in immune response
Immune response_NFAT in immune response1.00
Immune response NFAT in immune response0.91
2Immune response_ICOS pathway in T-helper cell
Immune response_ICOS pathway in T-helper cell1.00
Immune response ICOS pathway in T-helper cell0.91
3G-protein signaling N-RAS regulation pathway
G-protein signaling N-RAS regulation pathway1.00
G-protein signaling_N-RAS regulation pathway0.83
4Immune response IL-22 signaling pathway
Immune response IL-22 signaling pathway1.00
Immune response_IL-22 signaling pathway0.87
5Immune response T cell receptor signaling pathway
Immune response T cell receptor signaling pathway1.00
Immune response_T cell receptor signaling pathway0.88

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 EMD Millipore Pathways for HLA-DPB2 (see all 6)
    Immune response Antigen presentation by MHC class II
G-protein signaling N-RAS regulation pathway
Immune response IL-22 signaling pathway
Immune response NFAT in immune response
Immune response ICOS pathway in T-helper cell


5/6 GeneGo (Thomson Reuters) Pathways for HLA-DPB2 (see all 6)
    Immune response Antigen presentation by MHC class II
Immune response ICOS pathway in T-helper cell
Immune response T cell receptor signaling pathway
Immune response IL-22 signaling pathway
G-protein signaling N-RAS regulation pathway



HLA-DPB2 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HLA-DPB2

Drugs & Compounds
for HLA-DPB2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HLA-DPB2
Search CenterWatch for drugs/clinical trials and news about HLA-DPB2 

Transcripts
for HLA-DPB2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for HLA-DPB2:

Major histocompatibility complex, class II, DP beta 2 (pseudogene)
Hs.665450  [show with all ESTs]
Unigene Representative Sequence: AK301188
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000435074(uc003ocv.1) ENST00000470997(uc003ocw.1) ENST00000435499


miRNA
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Inhib. RNA
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Clone
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Primer
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Additional cDNA sequence: 

AK301188.1 BC017967.1 NR_001435.1 

3 DOTS entries:

DT.40201220  DT.91878430  DT.100729521 

24/599 AceView cDNA sequences (see all 599):

AI433575 BX279593 AA348191 BM665426 AA456492 BQ056734 BE552441 BM711504 
BC007963 AA778424 AA293396 AW796574 AI656151 CR619088 AA366659 CR605846 
CA309047 BG686251 AW951201 AA336524 BC017967 BE672867 BQ065862 BQ055498 

GeneLoc Exon Structure


Expression
for HLA-DPB2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HLA-DPB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCCCCCTT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

HLA-DPB2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
Stem Cell Differentiation: 1 LifeMap Cell 
NameCategory
Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

Genevestigator expression for HLA-DPB2

SOURCE GeneReport for Unigene cluster: Hs.665450
    SABiosciences Custom PCR Arrays for HLA-DPB2
Primer
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In Situ
Assay Products: 
 		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HLA-DPB2

Orthologs
for HLA-DPB2 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of human and mouse.

Orthologs for HLA-DPB2 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia H2-Pb5 histocompatibility 2, P region beta locus   --   17 (17.98 cM) 34073762 


ENSEMBL Gene Tree for HLA-DPB2 (if available)
TreeFam Gene Tree for HLA-DPB2 (if available) 

Paralogs
for HLA-DPB2 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for HLA-DPB2 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for HLA-DPB2
     3 CNVs: 51902 99497 7571
     3 Indels: 42876 62505 47109
Human Gene Mutation Database (HGMD): HLA-DPB2

Locus Specific Mutation Databases (LSDB): HLA-DPB2
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-DPB2
DNA2.0 Custom Variant and Variant Library Synthesis for HLA-DPB2

Disorders / Diseases
for HLA-DPB2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
HLA-DPB2 for disorders           About GeneDecksing

3 diseases for HLA-DPB2:    About MalaCards
treacher collins syndrome    myocardial infarction    nephropathy

1 disease from the University of Copenhagen DISEASES database for HLA-DPB2:
Treacher Collins syndrome
Human Genome Epidemiology (HuGE) Navigator: HLA-DPB2 (3 documents)

Export disorders for HLA-DPB2 gene to outside databases

Publications
for HLA-DPB2 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for HLA-DPB2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HLA-DPB2)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes. (PubMed id 3036829)1, 3 Gustafsson K.... Peterson P.A. (1987)
  2. Genome-wide association study identifies susceptibili ty loci for IgA nephropathy. (PubMed id 21399633)1 Gharavi A.G....Lifton R.P. (2011)
  3. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1 Ucisik-Akkaya E....Tevfik Dorak M. (2010)
  4. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PubMed id 20031603)1 Marroni F....Pramstaller P.P. (2009)
  5. HLA-DPB1 and DPB2 are genetic loci for systemic scler osis: a genome-wide association study in Koreans with replication in North Amer icans. (PubMed id 19950302)1 Zhou X....Lee E.B. (2009)
  6. Analysis of 17,576 potentially functional SNPs in three case-control studies of myocardial infarction. (PubMed id 18682748)1 Shiffman D....Devlin J.J. (2008)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

External Searches for HLA-DPB2 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing HLA-DPB2 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3116 HGNC: 4941 AceView: HLA-DPB1 Ensembl:ENSG00000224557 euGenes: HUgn3116
ECgene: HLA-DPB2 H-InvDB: HLA-DPB2

Other Databases showing HLA-DPB2 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing HLA-DPB2 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for HLA-DPB2 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for HLA-DPB2 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for HLA-DPB2 gene:
Search GeneIP for patents involving HLA-DPB2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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About This Section

 
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