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HLA-DPB2 Gene(Pseudogene)

Major Histocompatibility Complex, Class II, DP Beta 2 (Pseudogene)

GCID:
GC06P033080
GIFtS:
29
Genes Participants
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Aliases for HLA-DPB2 Gene

Aliases for HLA-DPB2 Gene

  • Major Histocompatibility Complex, Class II, DP Beta 2 (Pseudogene) 2 3 5
  • HLA-DP2B 3
  • DPbeta2 3
  • DP2B 3
  • DPB2 3

External Ids for HLA-DPB2 Gene

Previous HGNC Symbols for HLA-DPB2 Gene

  • HLA-DP2B

Previous GeneCards Identifiers for HLA-DPB2 Gene

  • GC06U990045
  • GC06P033127
  • GC06P033188
  • GC06P032822

Summaries for HLA-DPB2 Gene

GeneCards Summary for HLA-DPB2 Gene

HLA-DPB2 (Major Histocompatibility Complex, Class II, DP Beta 2 (Pseudogene)) is a Pseudogene. Among its related pathways are Immune response NFAT in immune response and Th17 cell differentiation.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-DPB2 Gene

Genomics for HLA-DPB2 Gene

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  1. Regulatory Element

Regulatory Elements for HLA-DPB2 Gene

Enhancers for HLA-DPB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G033079 1.2 ENCODE dbSUPER 47.1 -31.7 -31709 2.0 PKNOX1 GLI4 ZNF2 ZNF121 GLIS2 ZNF263 SP3 TSHZ1 REST PBX2 HLA-DPB1 HLA-DPB2 HLA-DPA1 RPL32P1 RING1 RXRB HLA-DMA HLA-DPA3 RPS18 GC06P033079
GH06G033116 1.1 Ensembl ENCODE 15.2 +5.1 5110 2.5 ELF3 HDGF PKNOX1 RB1 ZNF2 RAD21 RFX5 ZNF366 SCRT2 ZNF143 HLA-DPB1 HLA-DPA1 HLA-DPB2 HCG24 RPL32P1 COL11A2 HSD17B8 PIR46525 PIR47274
GH06G033270 1.5 ENCODE dbSUPER 7.5 +162.7 162678 8.4 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC RPS18 DAXX WDR46 BRD2 VPS52 RGL2 LEMD2 RXRB ITPR3 RING1
GH06G033016 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.8 -93.6 -93584 5.0 PKNOX1 ZNF493 ARID4B SIN3A ZNF2 YY1 ZNF121 GLIS2 ZNF143 KLF7 HCG25 HLA-DQA2 PPT2 HLA-DPB1 HLA-DPA1 RXRB HLA-DQB2 HLA-DMA COL11A2 BRD2
GH06G033191 1 Ensembl 9.9 +80.5 80532 2.1 ATF1 CREB3L1 AGO1 ARID4B SIN3A ZNF48 ZNF2 ZNF143 SP3 REST HLA-DPB1 HSD17B8 HLA-DPB2 COL11A2 HCG24
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HLA-DPB2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the HLA-DPB2 gene promoter:

Genomic Location for HLA-DPB2 Gene

Chromosome:
6
Start:
33,112,451 bp from pter
End:
33,129,113 bp from pter
Size:
16,663 bases
Orientation:
Plus strand

Genomic View for HLA-DPB2 Gene

Genes around HLA-DPB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-DPB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-DPB2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HLA-DPB2 Gene

Proteins for HLA-DPB2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for HLA-DPB2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for HLA-DPB2 Gene

Domains & Families for HLA-DPB2 Gene

Gene Families for HLA-DPB2 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HLA-DPB2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HLA-DPB2 Gene

Function for HLA-DPB2 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for HLA-DPB2 Gene

GENATLAS Biochemistry:
HLA-DP,beta chain-related pseudogene

Phenotypes for HLA-DPB2 Gene

GenomeRNAi human phenotypes for HLA-DPB2:
genes like me logo Genes that share phenotypes with HLA-DPB2: view

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HLA-DPB2 Gene

Localization for HLA-DPB2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HLA-DPB2 Gene

Pathways & Interactions for HLA-DPB2 Gene

genes like me logo Genes that share pathways with HLA-DPB2: view

Interacting Proteins for HLA-DPB2 Gene

Gene Ontology (GO) - Biological Process for HLA-DPB2 Gene

None

No data available for SIGNOR curated interactions for HLA-DPB2 Gene

Drugs & Compounds for HLA-DPB2 Gene

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  1. Drug

(1) Drugs for HLA-DPB2 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved, Vet_approved Pharma Channel blocker 1152
genes like me logo Genes that share compounds with HLA-DPB2: view

Transcripts for HLA-DPB2 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for HLA-DPB2 Gene

(3) Additional mRNA sequences :
(599) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HLA-DPB2 Gene

Major histocompatibility complex, class II, DP beta 2 (pseudogene):
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-DPB2 Gene

No ASD Table

Relevant External Links for HLA-DPB2 Gene

GeneLoc Exon Structure for
HLA-DPB2
ECgene alternative splicing isoforms for
HLA-DPB2

Expression for HLA-DPB2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HLA-DPB2 Gene

mRNA expression in normal human tissues for HLA-DPB2 Gene
mRNA expression by GTEx for HLA-DPB2 Gene

mRNA differential expression in normal tissues according to GTEx for HLA-DPB2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.0) and Brain - Cerebellum (x4.6).

SOURCE GeneReport for Unigene cluster for HLA-DPB2 Gene:

Hs.665450
genes like me logo Genes that share expression patterns with HLA-DPB2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-DPB2 Gene

Orthologs for HLA-DPB2 Gene

Evolution for HLA-DPB2 Gene

ENSEMBL:
Gene Tree for HLA-DPB2 (if available)
TreeFam:
Gene Tree for HLA-DPB2 (if available)

No data available for Orthologs for HLA-DPB2 Gene

Paralogs for HLA-DPB2 Gene

No data available for Paralogs for HLA-DPB2 Gene

Variants for HLA-DPB2 Gene

Sequence variations from dbSNP and Humsavar for HLA-DPB2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000171545 -- 33,116,617(+) CCCCC(-/T)GATGA intron-variant
rs1000365670 -- 33,126,424(+) CTTCC(C/T)AGGAC intron-variant
rs1000517215 -- 33,117,167(+) GGACA(A/T)GGTGT nc-transcript-variant
rs1000867397 -- 33,117,352(+) GGAGG(A/G)GCCCA intron-variant
rs1001086430 -- 33,115,672(+) CACAT(A/G)CACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HLA-DPB2 Gene

Variant ID Type Subtype PubMed ID
dgv1000e201 CNV deletion 23290073
dgv1760e212 CNV loss 25503493
esv2199795 CNV deletion 18987734
esv2650098 CNV deletion 19546169
esv2676552 CNV deletion 23128226
esv2731885 CNV deletion 23290073
esv3157 CNV loss 18987735
esv32606 CNV gain 17666407
esv33191 CNV gain 17666407
esv3567589 CNV deletion 23714750
esv7387 CNV loss 19470904
nsv1024429 CNV loss 25217958
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv516221 CNV loss 19592680
nsv602818 CNV loss 21841781

Relevant External Links for HLA-DPB2 Gene

Human Gene Mutation Database (HGMD)
HLA-DPB2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HLA-DPB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HLA-DPB2 Gene

Disorders for HLA-DPB2 Gene

Relevant External Links for HLA-DPB2

Genetic Association Database (GAD)
HLA-DPB2
Human Genome Epidemiology (HuGE) Navigator
HLA-DPB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HLA-DPB2

No disorders were found for HLA-DPB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HLA-DPB2 Gene

Publications for HLA-DPB2 Gene

  1. Genome-wide association study identifies susceptibility loci for IgA nephropathy. (PMID: 21399633) Gharavi A.G. … Lifton R.P. (Nat. Genet. 2011) 3 46 64
  2. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E. … Dorak M.T. (Mol. Hum. Reprod. 2010) 3 46 64
  3. HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: a genome-wide association study in Koreans with replication in North Americans. (PMID: 19950302) Zhou X. … Lee E.B. (Arthritis Rheum. 2009) 3 46 64
  4. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PMID: 20031603) Marroni F. … Pramstaller P.P. (Circ Cardiovasc Genet 2009) 3 46 64
  5. Analysis of 17,576 potentially functional SNPs in three case-control studies of myocardial infarction. (PMID: 18682748) Shiffman D. … Devlin J.J. (PLoS ONE 2008) 3 46 64

Products for HLA-DPB2 Gene

Sources for HLA-DPB2 Gene

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