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HLA-DPB1 Gene

protein-coding   GIFtS: 62
GCID: GC06P033043

Major Histocompatibility Complex, Class II, DP Beta 1


(Previous symbol: HLA-DP1B)
  See HLA-DPB1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Major Histocompatibility Complex, Class II, DP Beta 11 2     HLA DP14-Beta Chain2
HLA-DP1B1 2 3     HLA-DP Histocompatibility Type, Beta-1 Subunit2
HLA Class II Histocompatibility Antigen, DP(W4) Beta Chain2 3     Major Histocompatibility Complex Class II Antigen Beta Chain2
MHC Class II Antigen DPB12 3     MHC Class II Antigen Beta Chain2
DPB12     MHC Class II Antigen DP Beta 1 Chain2
HLA-DP2     MHC Class II Antigen DPbeta12
HLA-DPB2     MHC Class II HLA-DP-Beta-12
Beta1 Domain MHC Class II HLA DPB2     MHC Class II HLA-DRB12
Class II HLA Beta Chain2     MHC HLA DPB12
HLA Class II Histocompatibility Antigen, DP Beta 1 Chain2     

External Ids:    HGNC: 49401   Entrez Gene: 31152   Ensembl: ENSG000002238657   OMIM: 1428585   UniProtKB: P044403   

Export aliases for HLA-DPB1 gene to outside databases

Previous GC identifers: GC06P033046 GC06P033090 GC06P033151 GC06P032786


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HLA-DPB1 Gene:
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of
an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune
system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen
presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa
and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular
domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule
both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities,
resulting in up to 4 different molecules. (provided by RefSeq, Jul 2008)

GeneCards Summary for HLA-DPB1 Gene:
HLA-DPB1 (major histocompatibility complex, class II, DP beta 1) is a protein-coding gene. Diseases associated with HLA-DPB1 include beryllium disease, chronic, and chronic berylliosis. An important paralog of this gene is HLA-DRB5.

UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440
Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
(class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the
regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
efficient peptide loading

Gene Wiki entry for HLA-DPB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NT_167244.2  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  NT_167249.2  
NC_018917.2  NT_113891.3  
Regulatory elements:
   Regulatory transcription factor binding sites in the HLA-DPB1 gene promoter:
         GR   Pbx1a   p300   FOXD3   CUTL1   MIF-1   Cdc5   STAT3   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLA-DPB1 promoter sequence
   Search Chromatin IP Primers for HLA-DPB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-DPB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

HLA-DPB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-DPB1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P033043:  view genomic region     (about GC identifiers)

Start:
33,043,703 bp from pter      End:
33,057,473 bp from pter
Size:
13,771 bases      Orientation:
plus strand

Selected alternative locations (see all 7):
Chr6+,NT_167244 4,330,504-4,344,264      Chr6+,NT_167247 4,380,558-4,394,318      Chr6+,NT_167249 4,524,207-4,537,977     
Chr6+,NT_167248 4,276,154-4,289,926      Chr6+,NT_167246 4,501,243-4,515,019      Chr6+,NT_167245 4,325,042-4,338,804     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen, DP beta 1 chain precursor  
Size: 258 amino acids; 29159 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Sequence caution: Sequence=AAQ12564.1; Type=Frameshift; Positions=39;
1 PDB 3D structure from and Proteopedia for HLA-DPB1:
3LQZ (3D)    
Secondary accessions: A0PFJ7 A5I886 A8YPB3 B5U8B4 B7VF80 B7VF87 B8ZX68 B8ZYT0 B9W5S8 B9W6F7
B9W6F9 C0MPP5 C0MPQ2 C0MPQ3 C0MPQ5 C0MPQ6 C0MPQ7 C4R9J5 C5IZL1 O00259 O19698 O19700 O19702
O19749 O46884 O77952 O98215 O98216 O98217 O98218 O98219 O98222 O98223 P01916 P04232 P13763
P79493 P79608 Q0P0L4 Q0ZFN3 Q14279 Q27S71 Q29682 Q29684 Q29698 Q29714 Q29775 Q29776 Q29778
Q29779 Q29781 Q29827 Q29828 Q29879 Q29880 Q29898 Q29977 Q2MGW3 Q30015 Q30031 Q30032 Q30033
Q30034 Q30050 Q30051 Q30052 Q30053 Q30054 Q30055 Q30174 Q4GY31 Q4JHD8 Q5ENE0 Q5ENE1 Q5ENW3
Q5EP46 Q5EP47 Q5EP49 Q5EP51 Q5EP52 Q5EP53 Q5EP56 Q5I4H8 Q5I4H9 Q5ISH4 Q5ISH5 Q5SQ73 Q5STP2
Q5YLA6 Q6IVX1 Q6LBX2 Q6LBX3 Q6LBX4 Q6LBX5 Q6LBX6 Q6LBX7 Q6PWX6 Q6TAS4 Q714U1 Q714U2 Q7YQ10
Q860Z7 Q8HWL7 Q8HWT5 Q8SNC4 Q95HC1 Q95IT7 Q95IT8 Q9BD13 Q9GIM2 Q9GIM4 Q9GIX6 Q9GJ41 Q9MY67
Q9TNT7 Q9TQE2 Q9XS11 Q9XS12

Explore the universe of human proteins at neXtProt for HLA-DPB1: NX_P04440

Explore proteomics data for HLA-DPB1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn48
  • Modification sites at PhosphoSitePlus

  • See HLA-DPB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002112.3  
    ENSEMBL proteins: 
     ENSP00000408146   ENSP00000412654   ENSP00000399832   ENSP00000439674  
    Reactome Protein details: P04440

    HLA-DPB1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for HLA-DPB1 (5 products) 

     
    antibodies-online peptides for HLA-DPB1

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    HLA-DPB1 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    HGNC Gene Families:
    HLA: Histocompatibility complex
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    Selected InterPro protein domains (see all 7):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR000353 MHC_II_b_N
     IPR013783 Ig-like_fold
     IPR014745 MHC_II_a/b_N
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry P04440

    ProtoNet protein and cluster: P04440

    3 Blocks protein domains:
    IPB000353 Class II histocompatibility antigen
    IPB001003 MHC Class II alpha chain
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Find genes that share domains with HLA-DPB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPB1_HUMAN, P04440
    Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
    and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
    peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
    of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
    hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
    via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
    As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
    contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
    endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
    MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
    epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
    tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
    an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
    of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
    degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
    (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
    the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
    affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
    membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
    Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the
    regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
    efficient peptide loading

         Genatlas biochemistry entry for HLA-DPB1:
    HLA-DP,beta chain

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with HLA-DPB1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HLA-DPB1

    miRNA
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    Block miRNA regulation of human, mouse, rat HLA-DPB1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HLA-DPB1:
    hsa-miR-767-3p hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidHLA-DPB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HLA-DPB1
    Predesigned siRNA for gene silencing in human, mouse, rat HLA-DPB1

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: HLA-DPB1 (NM_002121)
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    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DPB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPB1_HUMAN, P04440: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic
    pathway until it reaches the cell membrane for antigen presentation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome5
    lysosome5
    plasma membrane5
    vacuole5
    golgi apparatus4
    extracellular2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005765lysosomal membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane IEA--
    GO:0012507ER to Golgi transport vesicle membrane TAS--

    Find genes that share ontologies with HLA-DPB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HLA-DPB1 About   (see all 20)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Allograft rejection
    Allograft rejection0.86
    Asthma0.46
    Allograft Rejection0.86
    Intestinal immune network for IgA production0.41
    Type I diabetes mellitus0.69
    Viral myocarditis0.40
    Graft-versus-host disease0.65
    Antigen processing and presentation0.36
    2Translocation of ZAP-70 to Immunological synapse
    Translocation of ZAP-70 to Immunological synapse0.83
    PD-1 signaling0.72
    Phosphorylation of CD3 and TCR zeta chains0.83
    Generation of second messenger molecules0.62
    3Immune response Antigen presentation by MHC class II
    Immune response Antigen presentation by MHC class II0.46
    Immune response IL 22 signaling pathway0.31
    G protein signaling N RAS regulation pathway0.46
    4Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    5Immune response NFAT in immune response
    Immune response NFAT in immune response0.55
    Immune response T cell receptor signaling pathway0.50
    Immune response ICOS pathway in T helper cell0.55


    Find genes that share SuperPaths with HLA-DPB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for HLA-DPB1 (see all 6)
        Immune response Antigen presentation by MHC class II
    Immune response ICOS pathway in T-helper cell
    Immune response T cell receptor signaling pathway
    Immune response IL-22 signaling pathway
    G-protein signaling N-RAS regulation pathway

    1 BioSystems Pathway for HLA-DPB1
        Allograft Rejection

    1 Sino Biological Pathway for HLA-DPB1
        NF-kB (NFkB) Pathway

    Selected Reactome Pathways for HLA-DPB1 (see all 7)
        Translocation of ZAP-70 to Immunological synapse
    Interferon gamma signaling
    Downstream TCR signaling
    PD-1 signaling
    MHC class II antigen presentation


    Selected Kegg Pathways  (Kegg details for HLA-DPB1) (see all 21):
        Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Intestinal immune network for IgA production
    Type I diabetes mellitus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HLA-DPB1
    Interactions:

        GeneGlobe Interaction Network for HLA-DPB1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for HLA-DPB1 (P044402, 3 ENSP000004081464) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ROBO2Q9HCK42, 3MINT-8258142 I2D: score=2 
    RTN4Q9NQC32, 3MINT-8258153 I2D: score=2 
    HLA-DPA1P200363, ENSP000003935664I2D: score=1 STRING: ENSP00000393566
    ENSG00000168384P200363I2D: score=1 
    ENSG00000206291P200363I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002504antigen processing and presentation of peptide or polysaccharide antigen via MHC class II ----
    GO:0006955immune response ----
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0019882antigen processing and presentation ----
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    Find genes that share ontologies with HLA-DPB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HLA-DPB1 (DPB1)

    4 Novoseek inferred chemical compound relationships for HLA-DPB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpa 1 96.1 37 11556979 (4), 1348744 (3), 7710763 (2), 8225437 (2) (see all 15)
    beryllium 66.1 7 10415070 (2), 11551429 (2), 10860658 (1), 14662898 (1)
    oligonucleotide 30.5 6 8436419 (1), 8863870 (1), 10566595 (1), 1971269 (1) (see all 5)
    glutamate 0 1 11551429 (1)



    Find genes that share compounds with HLA-DPB1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for HLA-DPB1 gene: 
    NM_002121.5  

    Unigene Cluster for HLA-DPB1:

    Major histocompatibility complex, class II, DP beta 1
    Hs.485130  [show with all ESTs]
    Unigene Representative Sequence: NM_002121
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418931(uc003ocu.2 uc011dqo.2) ENST00000469120 ENST00000471184
    ENST00000488575 ENST00000498038 ENST00000428835 ENST00000416804(uc011dqq.1)
    ENST00000478189 ENST00000535465(uc011dqn.2)
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    OriGene clones in human, mouse for HLA-DPB1 (see all 8)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLA-DPB1 (NM_002121)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-DPB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DPB1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HLA-DPB1
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-DPB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HLA-DPB1
      QuantiTect SYBR Green Assays in human, mouse, rat HLA-DPB1
      QuantiFast Probe-based Assays in human, mouse, rat HLA-DPB1

    Additional mRNA sequence: 

    AB208978.1 AK291986.1 AK301322.1 AK303153.1 AK313305.1 AY656678.1 AY656679.1 AY656680.1 
    AY804132.1 AY804133.1 AY804134.1 AY804135.1 AY804136.1 AY804137.1 AY804138.1 AY804139.1 
    AY804140.1 AY804141.1 AY804142.1 AY804143.1 AY831401.1 AY831402.1 AY831403.1 AY831404.1 
    BC007963.2 BC013184.1 BC015000.1 BT019780.1 DQ284441.1 FR775797.1 FR775798.1 GQ891549.1 
    HE603611.1 HE603612.1 HE614584.1 HE614585.1 HE614586.1 HE614587.1 HE614588.1 HE614589.1 
    HE614590.1 HE614591.1 J03041.1 K00409.1 K01615.1 L29173.1 M21886.1 M28200.1 
    M28201.1 M28202.1 M57466.1 M83664.1 S66883.1 S79786.1 X00532.1 X01426.1 
    X03067.1 

    Selected DOTS entries (see all 35):

    DT.100826689  DT.91878430  DT.91791833  DT.452653  DT.100826691  DT.95269923  DT.40127111  DT.75122389 
    DT.121402840  DT.121402869  DT.104576  DT.300839  DT.97800984  DT.101961746  DT.121402689  DT.86858814 
    DT.91661820  DT.91761305  DT.95338993  DT.100044867  DT.121402700  DT.121402836  DT.121402845  DT.91720260 

    Selected AceView cDNA sequences (see all 599):

    CA439616 AA778424 W20380 AA293564 AA486532 BQ065862 BC017967 AA361875 
    BF724819 BQ066305 BQ007765 CA309047 AA507462 BM665426 BX279593 AI656151 
    BI062287 AA348191 NM_002121 BG686251 BU175417 AI214298 AW610196 CR619088 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HLA-DPB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCCTTCTT
    HLA-DPB1 Expression
    About this image


    HLA-DPB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
     
     Tonsil (Hematopoietic System)
     
     Spleen (Hematopoietic System)
    HLA-DPB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HLA-DPB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485130
        Custom PCR Arrays for HLA-DPB1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HLA-DPB1
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-DPB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HLA-DPB1
    QuantiTect SYBR Green Assays in human, mouse, rat HLA-DPB1
    QuantiFast Probe-based Assays in human, mouse, rat HLA-DPB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DPB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-DPB1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia HLA-DPB16
    major histocompatibility complex, class II, DP bet...
    50(a)
    1 ↔ 1
    12(2604546-2607784)
    chicken
    (Gallus gallus)
    Aves BLB31 Major histocompatibility complex class II beta chain more 65.72(n)
    54.03(a)
      425256  XM_423039.4  XP_423039.4 


    ENSEMBL Gene Tree for HLA-DPB1 (if available)
    TreeFam Gene Tree for HLA-DPB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for HLA-DPB1 gene
    HLA-DRB52  HLA-DQA12  HLA-DPA12  HLA-DQB12  HLA-DRA2  HLA-DRB12  HLA-DOB2  HLA-DMA2  
    HLA-DQB22  HLA-DOA2  ENSG000002489932  HLA-DMB2  HLA-DQA22  
    Selected SIMAP similar genes for HLA-DPB1 using alignment to 265 protein entries:     DPB1_HUMAN (see all proteins) (see all similar genes):
    HLA-SB beta    HLA-DPB    HLA-DP    DPB1    MHC DPB1    HLA-DB1
    MHC-DPB1*6001    HLA-D8.2V    HLA-DRB13    HLA-DRB1*1327    HLA-DRB4*0102    HLA-DRB14
    HLA-DRB1*0801    HLQ-DQB1    HLA-DRB1*11    HLA-DRB1*1125    HLA-DRBI*1303    HLA-DRB1*1605

    Find genes that share paralogs with HLA-DPB1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for HLA-DPB1
    PGOHUM00000260171 PGOHUM00000260853


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Polymorphic Variants from UniProtKB/Swiss-Prot
    DPB1_HUMAN, P04440: The following alleles of HLA-DPB1 are known: DPB1*01:01, DPB1*01:02, DPB1*02:01, DPB1*02:02,
    DPB1*02:03, DPB1*03:01, DPB1*03:02, DPB1*04:01, DPB1*04:02, DPB1*04:03, DPB1*05:01, DPB1*05:02, DPB1*06:01,
    DPB1*06:02, DPB1*08:01, DPB1*08:02, DPB1*09:01, DPB1*09:02, DPB1*10:01, DPB1*10:02, DPB1*11:01, DPB1*11:02,
    DPB1*13:01, DPB1*13:02, DPB1*14:01, DPB1*14:02, DPB1*15:01, DPB1*15:02, DPB1*16:01, DPB1*16:02, DPB1*17:01,
    DPB1*17:02, DPB1*18:01, DPB1*18:02, DPB1*19:01, DPB1*19:02, DPB1*20:01, DPB1*20:02, DPB1*21:01, DPB1*21:02,
    DPB1*22:01, DPB1*22:02, DPB1*23:01, DPB1*24:01, DPB1*24:02, DPB1*25:01, DPB1*25:02, DPB1*26:01, DPB1*26:02,
    DPB1*27:01, DPB1*28:01, DPB1*29:01, DPB1*30:01, DPB1*31:01, DPB1*32:01, DPB1*33:01, DPB1*34:01, DPB1*35:01,
    DPB1*36:01, DPB1*37:01, DPB1*38:01, DPB1*39:01, DPB1*40:01, DPB1*41:01, DPB1*44:01, DPB1*45:01, DPB1*46:01,
    DPB1*47:01, DPB1*48:01, DPB1*49:01, DPB1*50:01, DPB1*51:01, DPB1*52:01, DPB1*53:01, DPB1*54:01, DPB1*55:01,
    DPB1*56:01, DPB1*57:01, DPB1*58:01, DPB1*59:01, DPB1*60:01, DPB1*62:01, DPB1*63:01, DPB1*65:01, DPB1*66:01,
    DPB1*67:01, DPB1*68:01, DPB1*69:01, DPB1*70:01, DPB1*71:01, DPB1*72:01, DPB1*73:01, DPB1*74:01, DPB1*75:01,
    DPB1*76:01, DPB1*77:01, DPB1*78:01, DPB1*79:01, DPB1*80:01, DPB1*81:01, DPB1*82:01, DPB1*83:01, DPB1*84:01,
    DPB1*85:01, DPB1*86:01, DPB1*87:01, DPB1*88:01, DPB1*89:01, DPB1*90:01, DPB1*91:01, DPB1*92:01, DPB1*93:01,
    DPB1*94:01, DPB1*95:01, DPB1*96:01, DPB1*97:01, DPB1*98:01 and DPB1*99:01. The sequence shown is that of
    DPB1*04:01


    493 SNPs for HLA-DPB1 (see top 10)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10421401,2,,4
    C,Fother132964610(+) AGGAGA/C/G/
            
    AGCGG
    2 K E mis110MN NA WA CSA EA EU 6274
    rs1415302331,2
    C--33048688(+) GGGCG-/AGGCCC 2 G EA fra10--------
    rs3757949251,2
    C--33050526(+) ATGTC-/TCACCC 1 -- int10--------
    rs1907550351,2
    --33050561(+) GTTTTC/TTGGGC 1 -- int10--------
    rs31289601,2
    C,F,H--33050654(+) TATCAA/GGCCTT 1 -- int113Minor allele frequency- G:0.47NS EA WA NA CSA 781
    rs30976731,2
    C,F,H--33050671(+) AGCGCA/CCCCTG 1 -- int110Minor allele frequency- C:0.42NS WA NA CSA EA 481
    rs30976741,2
    C,F,H--33050683(+) AGGTCA/C/GCTGAT 1 -- int113NS EA WA NA CSA 749
    rs31289611,2
    C,F,O,H--33050742(+) CTCTCA/GTGGAA 1 -- int113Minor allele frequency- G:0.47NS EA WA NA CSA 771
    rs1150218821,2
    F--33050796(+) TTCATG/AGTTCC 1 -- int11Minor allele frequency- A:0.01NA 120
    rs92773921,2
    C,F--33050829(+) TTGTAC/GGTAAT 1 -- int112Minor allele frequency- G:0.49NA WA CSA EA 505
    rs92773931,2
    C,F--33050877(+) TGGACG/ATTGAG 1 -- int112Minor allele frequency- A:0.49NA WA CSA EA 505
    rs1154000851,2
    F--33050913(+) ACACAG/AGTGCC 1 -- int11Minor allele frequency- A:0.01NA 120
    rs92773941,2
    C,F,H--33050970(+) GTCTGT/AAAACA 1 -- int113Minor allele frequency- A:0.46NS EA WA NA CSA 769
    rs737416361,2
    C--33050993(+) AATAGG/AGAGTA 1 -- int12Minor allele frequency- A:0.02WA 120
    rs92773951,2
    C,F,H--33051051(+) ATGTTG/AGGGTA 1 -- int113Minor allele frequency- A:0.46NS EA WA NA CSA 765
    rs1477157051,2
    C--33051081(+) AGAAAG/TGAAAG 1 -- int10--------
    rs1819022351,2
    --33051093(+) ACTGAA/GTGATT 1 -- int10--------
    rs92773961,2
    C,F,H--33051139(+) GATGAG/ACTGTT 1 -- int121Minor allele frequency- A:0.47NS EA WA NA CSA 2347
    rs1848867991,2
    --33051158(+) TAGTCC/GTCTGA 1 -- int10--------
    rs1898801971,2
    --33051200(+) GAACTC/GTTCTC 1 -- int10--------
    rs92773971,2
    C--33051277(+) TTCTCG/ACTTTG 1 -- int17Minor allele frequency- A:0.49NA WA CSA EA 365
    rs92773981,2
    C--33051280(+) TCACTC/TTGTCT 1 -- int17Minor allele frequency- T:0.49NA WA CSA EA 365
    rs92773991,2
    C--33051307(+) GTGGCA/GCCATC 1 -- int15Minor allele frequency- G:0.40NA WA EA 246
    rs92774001,2
    C--33051316(+) TCATGA/GCTCAC 1 -- int14Minor allele frequency- G:0.47NA WA EA 126
    rs1409643791,2
    --33051317(+) CATGGC/TTCACT 1 -- int10--------
    rs92774011,2
    C,F--33051394(+) ATACAT/CGTACC 1 -- int19Minor allele frequency- C:0.47WA NA CSA EA 369
    rs1450807631,2
    --33051395(+) TACACA/GTACCA 1 -- int10--------
    rs1832158971,2
    --33051416(+) CTAATC/TTATTT 1 -- int10--------
    rs1509597111,2
    --33051427(+) TTCTTC/TTTAGA 1 -- int10--------
    rs92774021,2
    C,F--33051460(+) CAGGCC/TGGTCT 1 -- int16Minor allele frequency- T:0.41NA WA CSA EA 248
    rs92774031,2
    C--33051467(+) GTCTCA/GAAACC 1 -- int15Minor allele frequency- G:0.40NA WA EA 246
    rs92774041,2
    C--33051493(+) CCTCAT/CGCCTC 1 -- int15Minor allele frequency- C:0.40NA WA EA 246
    rs92774051,2
    C--33051500(+) CCTCAA/GCCTCC 1 -- int15Minor allele frequency- G:0.40NA WA EA 246
    rs92774061,2
    C--33051554(+) TCTGCC/TTTCTG 1 -- int17Minor allele frequency- T:0.47NA WA CSA EA 365
    rs92774071,2
    C--33051558(+) CTTTCC/TGAGGA 1 -- int17Minor allele frequency- T:0.48NA WA CSA EA 365
    rs92774081,2
    C--33051562(+) CTGAGA/GAGGAA 1 -- int17Minor allele frequency- G:0.47NA WA CSA EA 365
    rs92774091,2
    C,F,H--33051624(+) AAATTG/CACCTG 1 -- int113Minor allele frequency- C:0.46NS EA WA NA CSA 779
    rs92774101,2
    C,F,H--33051640(+) AACAGA/GACAAG 1 -- int112Minor allele frequency- G:0.47NS EA WA NA CSA 771
    rs92774111,2
    C--33051683(+) CAACAT/CCTGGT 1 -- int18Minor allele frequency- C:0.49WA NA CSA EA 367
    rs92774121,2
    C,F,H--33051689(+) CTGGTC/TATCTG 1 -- int113Minor allele frequency- T:0.45NS EA WA NA CSA 1163
    rs92774131,2
    C--33051720(+) AAGACA/GCAGCA 1 -- int10--------
    rs92774141,2
    C--33051723(+) ACGCAG/TCACAG 1 -- int10--------
    rs92774171,2
    C--33051741(+) ACTTGA/GAAAAG 1 -- int10--------
    rs3678567771,2
    C--33051741(+) CTTGA-/AGACACA
    TCCTTTTGG
    AAAAG
    1 -- int10--------
    rs1150829231,2
    F--33051747(+) AAAAGG/AACGGG 1 -- int11Minor allele frequency- A:0.02NA 120
    rs92774181,2
    C--33051749(+) AAGGAT/CGGGAT 1 -- int12Minor allele frequency- C:0.00WA 4
    rs1406696981,2
    --33051775(+) ATGTAA/GGAGCT 1 -- int10--------
    rs92774191,2
    C,F,H--33051777(+) GTAGGG/AGCTCA 1 -- int18Minor allele frequency- A:0.34EA NS WA NA CSA 301
    rs92774201,2
    C--33051790(+) ATATTA/CTGTAA 1 -- int16Minor allele frequency- C:0.49WA CSA NA EA 363
    rs92774211,2
    C,F,H--33051820(+) TTGTAG/AGTGAG 1 -- int115Minor allele frequency- A:0.46NS EA NA WA CSA 1974
    rs1441476571,2
    C--33051827(+) GAGGT-/AAAAAA 1 -- int10--------
    rs92824111,2
    C--33051834(+) AAAAA-/ATACAT 1 -- int10--------
    rs92774221,2
    C--33051838(+) AATACC/ATAGGT 1 -- int12Minor allele frequency- A:0.25WA NA 4
    rs1159698891,2
    F--33051839(+) ATACAT/CAGGTT 1 -- int12Minor allele frequency- C:0.07WA EA 238
    rs92774231,2
    C--33051845(+) AGGTTT/ATTTAC 1 -- int16Minor allele frequency- A:0.49WA NA EA 364
    rs92774241,2
    C,F,H--33051865(+) CATGTC/AAAGCT 1 -- int111Minor allele frequency- A:0.48NS EA WA NA CSA 777
    rs1429750551,2
    C--33051896(+) TCATG-/AAATA 
            
    AAGTT
    1 -- int10--------
    rs92774251,2
    C--33051899(+) ATGAAA/GTTATT 1 -- int10--------
    rs92824121,2
    C--33051900(+) GAAGT-/AAAGG 
            
    TATTA
    1 -- int10--------
    rs1168185051,2
    C--33051900(+) TGAAGG/TTATTA 1 -- int10--------
    rs92774261,2
    C,F,H--33051910(+) AGATTC/AACAGG 1 -- int120Minor allele frequency- A:0.47NS EA NA WA CSA 2345
    rs92774271,2
    C--33051969(+) AGTAAT/ATTTTG 1 -- int18Minor allele frequency- A:0.48WA NA CSA EA 367
    rs92774281,2
    C,F,H--33051976(+) TTTGCA/TTCCTT 1 -- int18Minor allele frequency- T:0.42NS WA NA CSA EA 469
    rs92774291,2
    C--33052007(+) AAAAGA/GTAGGT 1 -- int14Minor allele frequency- G:0.48WA NA EA 360
    rs92774301,2
    C--33052008(+) AAAGGC/TAGGTA 1 -- int14Minor allele frequency- T:0.48WA NA EA 360
    rs92774311,2
    C,F,H--33052028(+) TTGATT/CAAATA 1 -- int112Minor allele frequency- C:0.47NS EA WA NA CSA 771
    rs92774321,2
    C,F,H--33052072(+) TCCTAT/AATGTG 1 -- int112Minor allele frequency- A:0.46NS EA WA NA CSA 771
    rs1880945061,2
    --33052087(+) AGAGTA/GCAAAC 1 -- int10--------
    rs92774331,2
    C--33052128(+) ACTAAT/CTATTA 1 -- int17Minor allele frequency- C:0.48WA NA CSA EA 365
    rs105361911,2
    C--33052168(+) GAAGG-/TCTATT
            
    TCTAT
    1 -- int10--------
    rs1997258651,2
    C--33052175(-) AGATAA/GAAATA 1 -- int10--------
    rs92774341,2
    C,F,H--33052186(+) TTTCAA/GTGCTA 1 -- int117Minor allele frequency- G:0.46NS EA NA WA CSA 1985
    rs92774351,2
    C--33052220(+) ATTATA/TCCTAT 1 -- int11Minor allele frequency- T:0.00WA 2
    rs92774361,2
    C--33052221(+) TTATTT/CCTATT 1 -- int11Minor allele frequency- C:0.00WA 2
    rs92774371,2
    C,F,H--33052250(+) ATTACA/GTAGTG 1 -- int121Minor allele frequency- G:0.47NS EA NA WA CSA 2347
    rs92774381,2
    C--33052303(+) AGGCCT/CGTAAT 1 -- int17Minor allele frequency- C:0.50NA WA CSA EA 365
    rs92774391,2
    C--33052315(+) CCAGCC/ACTTTG 1 -- int15Minor allele frequency- A:0.42NA WA EA 246
    rs117594171,2
    H--33052318(+) gccctA/Ttgaga 1 -- int10--------
    rs92774401,2
    C--33052327(+) GAGGCC/TGAGCG 1 -- int15Minor allele frequency- T:0.42NA WA EA 246
    rs92774411,2
    C--33052354(+) TCAGGA/CGTTGG 1 -- int17Minor allele frequency- C:0.48WA NA EA 366
    rs18113591,2
    C,F--33052382(+) ACCAGC/GCTGAC 1 -- int18Minor allele frequency- G:0.49WA NA CSA EA 367
    rs1915104571,2
    --33052387(+) GCTGAA/CCAACA 1 -- int10--------
    rs92774431,2
    C,F--33052414(+) CTACTG/AATAAT 1 -- int16Minor allele frequency- A:0.18WA NA CSA 11
    rs92774441,2
    C,F,A--33052439(+) GGTGAA/GGTGGC 1 -- int16Minor allele frequency- G:0.40NA WA CSA EA 248
    rs92774451,2
    C,A--33052492(+) AATTGG/CTTGAA 1 -- int14Minor allele frequency- C:0.22NA WA 126
    rs92774461,2
    C,A--33052498(+) TTGAAG/CCCCGG 1 -- int15Minor allele frequency- C:0.32NA WA EA 246
    rs31289621,2
    C,F--33052502(+) AGCCCA/G/TGAGGT 1 -- int16NA WA CSA EA 247
    rs1125733601,2
    C--33052533(+) ATTGCG/ACCACT 1 -- int12Minor allele frequency- A:0.04WA NA 122
    rs92774471,2
    C,A--33052562(+) CAGAGC/TGACAC 1 -- int13Minor allele frequency- T:0.20WA NA CSA 5
    rs92774481,2
    C,A--33052572(+) CTCCAC/TCTCAA 1 -- int12Minor allele frequency- T:0.25WA NA 4
    rs1393761771,2
    C--33052581(+) AACAA-/AAAGA 
     AAGAATG
    AAAGA
    1 -- int10--------
    rs92774491,2
    C--33052615(+) GATTAC/TGTCTC 1 -- int12Minor allele frequency- T:0.33NA CSA 3
    rs3773985681,2
    C--33052621(+) TGTCT-/AAAAAAA 1 -- int10--------
    rs1403847761,2
    --33052668(+) AAGGAA/GGGAAG 1 -- int10--------
    rs798594571,2
    C--33052677(+) AGGAAA/GGAAGG 1 -- int10--------
    rs92774501,2
    C,F,A,H--33052695(+) CAAATT/GCTATT 1 -- int18Minor allele frequency- G:0.34NS EA WA NA EU 1610
    rs92774511,2
    C,F--33052711(+) ATTTTT/CCTTCC 1 -- int16Minor allele frequency- C:0.24NA WA EA EU 1624
    rs2006788311,2
    C--33052712(+) TTTTTC/TTTCCA 1 -- int11Minor allele frequency- T:0.00EU 1321
    rs92774521,2
    C,F,A--33052717(+) CTTCCA/CCGCTC 1 -- int11Minor allele frequency- C:0.28EU 1235
    rs92774531,2
    C,F,A--33052719(+) TCCACG/ACTCCT 1 -- int11Minor allele frequency- A:0.27EU 1200
    rs92774541,2
    C,F--33052723(+) CGCTCC/GTAGTC 1 -- int14Minor allele frequency- G:0.28NA WA EU 1267
    rs11265371,2,,4
    C,F--33052736(+) GCCTAG/AGGTGA 2 /K /R mis14Minor allele frequency- A:0.29NA WA EU 1295
    rs11265411,2
    C,F--33052743(+) GTGAAT/CGTTTC 2 /N syn16Minor allele frequency- C:0.29WA NA CSA EU 1312
    rs10421871,2
    C,F--33052768(+) GGCCCA/C/G/
            
    TGCAG
    4 M L V mis1 syn111MN WA NA CSA EA EU 1871
    rs617369361,2
    F--33052793(+) TGTCTG/ACCACG 2 /Y /C mis11Minor allele frequency- A:0.44NS 36
    rs10422121,2
    C,F--33052803(+) GTGACG/AGATTT 2 /T syn118Minor allele frequency- A:0.36NA EA MN NS WA CSA EU 6833
    rs617369351,2
    F--33052817(+) CCCAGG/ACAGCA 2 /D /G mis11Minor allele frequency- A:0.47NS 36
    rs617369341,2
    F--33052836(+) CGATGG/CTTCCT 2 /C /W mis11Minor allele frequency- C:0.35NS 34
    rs617369381,2
    F--33052919(+) CCTGGA/TGATGC 2 E V mis11Minor allele frequency- T:0.30NS 30
    rs1441816531,2
    C,F--33052948(+) AGGGAG/CATGTC 2 /H /D mis12Minor allele frequency- C:0.00NA EU 5863
    rs10423311,2
    C,F--33052950(+) GGAGAT/CGTCTA 2 /D syn113Minor allele frequency- C:0.38NA NS WA CSA EA EU 6298
    rs10423351,2,,4
    C,F--33052958(+) CTACAC/TCTGCC 2 T I mis113Minor allele frequency- T:0.38NA NS WA CSA EA EU 6295
    rs143621,2,,4
    C,F,H--33052981(+) CCAGCC/ATGGAT 2 /M /L mis115Minor allele frequency- A:0.13EA NS MN NA EU 7311
    rs10715971,2
    C,F--33052986(+) CTGGAT/CAGTCC 2 /D syn111Minor allele frequency- C:0.38NS WA NA CSA EA EU 6283
    rs415594241,2
    C,F--33052998(+) GTCACC/TGTGGA 2 T syn13Minor allele frequency- T:0.01NA EU 5861
    rs92774571,2
    C,F--33053026(+) TGACCA/C/GTCTAG 1 -- int110WA NA CSA EA EU 1673
    rs1425672491,2
    --33053080(+) ACTCAC/TCTTAT 1 -- int10--------
    rs756569431,2
    C,F--33053092(+) TTCTGC/TATCTA 1 -- int12Minor allele frequency- T:0.21NA EA 240
    rs803157641,2
    C,F--33053121(+) AAACCC/TCATCT 1 -- int12Minor allele frequency- T:0.21NA EA 240
    rs92774581,2
    C,F,H--33053167(+) CAGGGC/AAATGG 1 -- int113Minor allele frequency- A:0.46NS EA WA NA CSA 775
    rs1432693761,2
    --33053177(+) GAGACC/TTCCTG 1 -- int10--------
    rs1833087471,2
    C--33053188(+) ACCTTA/GGCTTA 1 -- int10--------
    rs348028751,2
    --33053193(+) GGCTTA/GGGGGT 1 -- int10--------
    rs92774591,2
    C--33053248(+) CACTGG/ACTGGT 1 -- int18Minor allele frequency- A:0.47WA NA CSA EA 367
    rs92774601,2
    C,F,H--33053252(+) GACTGA/GTCTCG 1 -- int111Minor allele frequency- G:0.49NS EA WA NA CSA 623
    rs92774611,2
    C,F,H--33053270(+) CACACA/TTAGGA 1 -- int15Minor allele frequency- T:0.43NS WA NA EA 460
    rs2004655641,2
    C--33053270(+) CACAC-/TTAGGAA 1 -- int10--------
    rs92774621,2
    C,F,H--33053271(+) ACACTT/CAGGAA 1 -- int117Minor allele frequency- C:0.47NS EA WA CSA NA 2340
    rs92774631,2
    C,F,H--33053307(+) TCTTCT/CTTCAG 1 -- int193Minor allele frequency- C:0.46NS EA PA EU CA WA NA CSA 5278
    rs92774641,2
    C,F,H--33053352(+) ACTTCC/TAGAAT 1 -- int122Minor allele frequency- T:0.31NS EA NA WA EU 3044
    rs1483296571,2
    --33053393(+) CCTGTC/TCCAGA 1 -- int10--------
    rs92774651,2
    C,F--33053396(+) GTTCCA/GGATAT 1 -- int17Minor allele frequency- G:0.28WA NA EA EU 924
    rs92774661,2
    C,F--33053399(+) CCAGAC/TATGAG 1 -- int110Minor allele frequency- T:0.46WA NA CSA EA 370
    rs92774671,2
    C,F--33053444(+) TTTCCA/C/GCTGCA 1 -- int110WA NA CSA EA 372
    rs92774681,2
    C,F,H--33053455(+) CTGTCT/CTCATC 1 -- int113Minor allele frequency- C:0.47NS EA NA WA CSA 747
    rs92774691,2
    C,F,H--33053468(+) GATATG/TCTGCA 1 -- int122Minor allele frequency- T:0.47NS EA WA NA CSA 2349
    rs92774701,2
    C,F,H--33053477(+) CATCAC/GGCTCC 1 -- int114Minor allele frequency- G:0.46NS EA WA NA CSA 778
    rs1430915351,2
    C--33053559(+) AGAGGC/TACAGT 2 A V mis11Minor allele frequency- T:0.00NA 4552
    rs1427459111,2
    C--33053576(+) CTGCCC/TGGAGT 2 R W mis11Minor allele frequency- T:0.00NA 4552
    rs92761,2,,4
    C,F--33053577(+) TGCCCA/C/G/
            
    GAGTA
    4 Q P R L mis114NS EA WA NA CSA EU 6545
    rs115514211,2,,4
    C,F,H--33053609(-) CAGCAC/TGAAGC 2 M V mis116Minor allele frequency- T:0.08NS EA NA EU 8062
    rs30976751,2,,4
    C,F,O,H--33053640(+) GGGCAA/C/TCTTCA 3 N T I mis116NA NS EA CSA WA EU 6962
    rs1128359361,2
    C--33053667(+) GAAAGG/TTGAGA 1 -- spd11Minor allele frequency- T:0.00NA 4550
    rs1114830321,2
    C--33053669(+) AAGGTC/GAGAAA 1 -- int10--------
    rs92774711,2
    C,F,H--33053682(+) CTGCAG/AGGTGA 1 -- int123Minor allele frequency- A:0.44NS EA WA NA CSA EU 2933
    rs1117692851,2
    C--33053689(+) GTGAGC/TGGGAC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs95009311,2
    C,F--33053695(+) GGGACT/CTACCT 1 -- int14Minor allele frequency- C:0.05WA NA EU 829
    rs92774721,2
    C,F,H--33053723(+) ACTTAT/CTCCAC 1 -- int119Minor allele frequency- C:0.42NS EA WA NA CSA EU 2548
    rs92774731,2
    C,F--33053728(+) TTCCAC/TGATGA 1 -- int16Minor allele frequency- T:0.30NA WA CSA EU 539
    rs92774741,2
    C,F--33053737(+) GAGGGG/TTTTGA 1 -- int13Minor allele frequency- T:0.28WA EU 445
    rs92774751,2
    C,F--33053739(+) GGGGTT/CTGACA 1 -- int11Minor allele frequency- C:0.22EU 449
    rs92774761,2
    C--33053740(+) GGGTTA/TGACAG 1 -- int13Minor allele frequency- T:0.00WA CSA 5
    rs1406082791,2
    C--33053740(+) GGTTT-/A/CA  
            
    GACAG
    1 -- int10--------
    rs92774771,2
    C,F,H--33053772(+) TAGAGG/ACCACT 1 -- int18Minor allele frequency- A:0.45NS EA WA NA CSA 267
    rs92774781,2
    C--33053780(+) ACTGAA/TATCAG 1 -- int15Minor allele frequency- T:0.11WA NA CSA 9
    rs92774791,2
    C,F,H--33053789(+) AGATAG/ATCGGG 1 -- int19Minor allele frequency- A:0.45NS EA WA NA CSA 407
    rs1414011381,2
    --33053792(+) TAATCA/GGGGAA 1 -- int10--------
    rs92774801,2
    C,F,H--33053812(+) CCTATA/GGCGAG 1 -- int19Minor allele frequency- G:0.35NS EA WA NA 624
    rs92774811,2
    C,F--33053820(+) GAGAGA/G/TGGGAT 1 -- int18WA NA CSA EA 367
    rs412705221,2
    C,F--33053845(+) TTAATG/TCAGCC 1 -- int12Minor allele frequency- T:0.17NA EA 240
    rs92774821,2
    C--33053868(+) TCCCAG/AGTACT 1 -- int14Minor allele frequency- A:0.12WA NA 8
    rs92774831,2
    C--33053871(+) CAAGTG/ACTCAG 1 -- int13Minor allele frequency- A:0.17NA WA 6
    rs92774841,2
    C--33053877(+) CTCAGA/GCTCCT 1 -- int13Minor allele frequency- G:0.17NA WA 6
    rs92774851,2
    C--33053887(+) TGCGGG/AGCGTC 1 -- int12Minor allele frequency- A:0.00NA WA 4
    rs92774861,2
    C--33053890(+) GGAGCA/GTCCAT 1 -- int12Minor allele frequency- G:0.00NA WA 4
    rs92774871,2
    C--33053902(+) GAGTGG/ATGGGC 1 -- int14Minor allele frequency- A:0.00WA NA CSA 7
    rs92774881,2
    C,F,H--33053906(+) GATGGT/GCAATG 1 -- int15Minor allele frequency- G:0.26NS WA NA CSA 109
    rs1176550691,2
    C,F--33053932(+) GAAATG/ATTTCT 1 -- int11Minor allele frequency- A:0.03EA 120
    rs92774891,2
    C,F,H--33053942(+) TCTAAT/CTATCT 1 -- int127Minor allele frequency- C:0.32NS EA NA WA 2566
    rs92774901,2
    C,F--33053968(+) GCTGAT/ATATAT 1 -- int19Minor allele frequency- A:0.33WA NA CSA EA EU 1680
    rs92774911,2
    C,F--33053971(+) GATTAT/CATAAC 1 -- int16Minor allele frequency- C:0.29WA NA CSA EU 1320
    rs92774921,2
    C,F,H--33053982(+) CTTTCG/CTCTTT 1 -- int113Minor allele frequency- C:0.38NS EA WA NA CSA EU 2090
    rs1508188841,2
    C,F--33054000(+) GTTCAA/GCGAGG 2 Q syn12Minor allele frequency- G:0.01NA EU 5871
    rs2015529021,2
    --33054008(+) AGGATC/TTGCAT 2 S F mis10--------
    rs675238501,2
    C--33054014(+) TGCAT-/AAACAG 2 * syn10--------
    rs92774931,2
    C,F,H--33054046(+) CCTTGT/GGGGGT 1 -- int19Minor allele frequency- G:0.36EA NS WA NA CSA EU 1591
    rs2000133721,2
    --33054055(+) GTGGGC/TTGCAG 1 -- int10--------
    rs92774941,2
    C,F--33054057(+) GGGTTG/ACAGGA 1 -- int17Minor allele frequency- A:0.34WA NA EA EU 1682
    rs92774951,2
    C,F,H--33054071(+) TATGAC/GTCCTT 1 -- int16Minor allele frequency- G:0.26NS WA NA CSA 125
    rs92774961,2
    C--33054074(+) GAGTCC/TTTTCT 1 -- int14Minor allele frequency- T:0.31NA EA 244
    rs3683140141,2
    C--33054080(+) TTTCTC/GTGCAT 1 -- int10--------
    rs92774971,2
    C,F,H--33054091(+) TGTAAT/CACTGA 1 -- int112Minor allele frequency- C:0.47NS EA WA NA CSA 775
    rs1383303841,2
    C--33054100(+) AC/TCCTCC 1 -- int10--------
    rs92774981,2
    C--33054141(+) TTCAAC/TGTCAG 1 -- int12Minor allele frequency- T:0.33WA 120
    rs92774991,2
    C,F--33054142(+) TCAATC/GTCAGC 1 -- int12Minor allele frequency- G:0.44WA EA 238
    rs30976761,2
    C--33054145(+) ATGTCA/GGCCTT 1 -- int11Minor allele frequency- G:0.00NA 2
    rs92775031,2
    C--33054152(+) CCTTCA/GGGCAA 1 -- int10--------
    rs92775041,2
    C--33054155(+) TCAGGC/TAAGTG 1 -- int10--------
    rs92775051,2
    C--33054156(+) CAGGCA/GAGTGG 1 -- int10--------
    rs92775061,2
    C--33054167(+) GGAAAG/AAGCAT 1 -- int16Minor allele frequency- A:0.44NA WA EA 364
    rs92775071,2
    C,F--33054176(+) ATTGCT/ATGGCT 1 -- int13Minor allele frequency- A:0.43WA NA EA 358
    rs92775081,2
    C--33054177(+) TTGCTT/CGGCTC 1 -- int14Minor allele frequency- C:0.43WA NA EA 360
    rs92775091,2
    C--33054207(+) GATCAA/GCTCTG 1 -- int14Minor allele frequency- G:0.46WA NA EA 360
    rs92775101,2
    C--33054208(+) ATCAAC/TTCTGT 1 -- int14Minor allele frequency- T:0.46WA NA EA 360
    rs92775111,2
    C--33054215(+) CTGTTA/CTTTAT 1 -- int13Minor allele frequency- C:0.42WA NA 240
    rs92775121,2
    C--33054227(+) AGCCTA/GAGACG 1 -- int13Minor allele frequency- G:0.46WA EA 240
    rs92775131,2
    C--33054231(+) TGAGAC/TGCATC 1 -- int14Minor allele frequency- T:0.43WA NA EA 360
    rs92775141,2
    C--33054235(+) ACGCAT/GCCTCT 1 -- int15Minor allele frequency- G:0.43WA NA EA 362
    rs1923667761,2
    --33054244(+) CTCACC/TATAAT 1 -- int10--------
    rs737403031,2
    C--33054246(+) CACCAT/CAATTT 1 -- int12Minor allele frequency- C:0.05WA 120
    rs92775151,2
    C,F,H--33054268(+) ACTTAC/AAGGAA 1 -- int112Minor allele frequency- A:0.40NS EA WA NA CSA EU 1168
    rs92775161,2
    C,F--33054280(+) GAGGCT/CGGCAA 1 -- int13Minor allele frequency- C:0.44WA NA EA 358
    rs92775171,2
    C--33054281(+) AGGCTG/AGCAAC 1 -- int14Minor allele frequency- A:0.45WA NA EA 360
    rs92775181,2
    C,F,H--33054302(+) TTGTCT/CTTTAC 1 -- int113Minor allele frequency- C:0.42NS EA WA NA CSA EU 1191
    rs11267191,2
    C,F--33054325(+) CCTGAG/CCTCAC 1 -- ut318Minor allele frequency- C:0.50NA WA CSA EA 367
    rs11267231,2
    C--33054331(+) CTCACT/CGAAAA 1 -- ut314Minor allele frequency- C:0.49NA WA EA 360
    rs10424481,2
    C,F,H--33054342(+) GACTAA/TTGTGC 1 -- ut317Minor allele frequency- T:0.46NS EA NA WA 410
    rs92775221,2
    C,F--33054353(+) CTTAGG/AAAAAG 1 -- ut311Minor allele frequency- A:0.13EU 340
    rs92775231,2
    C,F--33054355(+) TAGGAA/CAAGCA 1 -- ut311Minor allele frequency- C:0.14EU 351
    rs10424671,2
    C,F--33054373(+) TGTTTC/TGTTAG 1 -- ut314Minor allele frequency- T:0.08MN NA WA EU 533
    rs1137794531,2
    C,F--33054378(+) CGTTAG/ACATCT 1 -- ut314Minor allele frequency- A:0.10WA NA EU 741
    rs10424881,2
    C,F--33054381(+) TAGCAT/CCTGGC 1 -- ut313Minor allele frequency- C:0.32MN NA WA 188
    rs10424971,2
    C,F--33054386(+) TCTGGC/TTCCAG 1 -- ut313Minor allele frequency- T:0.02MN NA WA 188
    rs10425021,2
    C,F--33054400(+) AGACCT/CTCAAC 1 -- ut313Minor allele frequency- C:0.01MN NA WA 188
    rs10425071,2
    C,F--33054404(+) CTTCAA/GCTTCC 1 -- ut313Minor allele frequency- G:0.01MN NA WA 188
    rs10425081,2
    C--33054410(+) CTTCCA/CAATTG 1 -- ut314Minor allele frequency- C:0.02MN WA NA CSA 189
    rs10425111,2
    C--33054413(+) CCAAAT/GTGGAT 1 -- ut315Minor allele frequency- G:0.29MN NA WA EA 544
    rs10425161,2
    C--33054414(+) CAAATT/AGGATA 1 -- ut314Minor allele frequency- A:0.31MN NA WA EA 424
    rs1133905521,2
    C--33054421(+) GATACG/TGCTGC 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs37499851,2
    C,F,H--33054433(+) AAGAAG/CTTGCT 1 -- ut3112Minor allele frequency- C:0.05NA NS EA WA CSA 801
    rs10425441,2
    C,F,H--33054457(+) CTATCA/GTTCTG 1 -- ut3123Minor allele frequency- G:0.45NS EA NA MN WA CSA 2529
    rs1140684681,2
    C,F--33054463(+) TTCTGC/TTCTTT 1 -- ut311Minor allele frequency- T:0.02NA 120
    rs9311,2
    C--33054550(+) AACATA/GACTGT 1 -- ut315Minor allele frequency- G:0.50WA CSA NA EA 362
    rs9281,2
    C--33054552(+) CATGAG/CTGTTT 1 -- ut315Minor allele frequency- C:0.49WA CSA NA EA 362
    rs1867489081,2
    --33054555(+) GACTGC/TTTGTT 1 -- ut310--------
    rs1125961571,2
    C--33054559(+) GTTTGT/CTTTCC 1 -- ut313Minor allele frequency- C:0.31WA NA 240
    rs9351,2
    C--33054579(+) ATGCAT/CCAAAT 1 -- ut314Minor allele frequency- C:0.14WA NA CSA 7
    rs9321,2
    C--33054586(+) AAATCG/ATCTCT 1 -- ut314Minor allele frequency- A:0.36MN WA NA CSA 189
    rs9331,2
    C--33054595(+) CTCATT/CACTTT 1 -- ut313Minor allele frequency- C:0.20WA NA CSA 5
    rs1444016101,2
    C--33054600(+) CACTT-/TTCTC 
            
    TGAGG
    1 -- ut310--------
    rs9291,2
    C,F,H--33054619(+) TAGTAA/GACAGT 1 -- ut3111Minor allele frequency- G:0.46NS EA WA NA CSA 771
    rs9301,2
    C--33054656(+) GTTTAC/AACATA 1 -- ut315Minor allele frequency- A:0.11WA NA CSA 9
    rs9341,2
    C,F--33054659(+) TAAACG/ATAGGA 1 -- ut315Minor allele frequency- A:0.22WA NA CSA 9
    rs92775291,2
    C--33054675(+) GAGAAG/CCATGA 1 -- ut315Minor allele frequency- C:0.11WA NA CSA 9
    rs1439353851,2
    --33054676(+) AGAACA/CATGAA 1 -- ut310--------
    rs92775301,2
    C--33054683(+) TGAAAG/ATGGGG 1 -- ut312Minor allele frequency- A:0.00NA WA 4
    rs92775311,2
    C--33054687(+) AATGGA/GGATAT 1 -- ut312Minor allele frequency- G:0.00NA WA 4
    rs92775321,2
    C--33054711(+) TAATGT/GGGCCT 1 -- ut316Minor allele frequency- G:0.46WA NA EA 364
    rs92775331,2
    C,F,H--33054721(+) TGTTAC/TACATG 1 -- ut3121Minor allele frequency- T:0.47NS EA NA WA CSA 2345
    rs92775341,2
    C,F,H--33054807(+) AGACCG/ACTATT 1 -- ut3122Minor allele frequency- A:0.49NS EA NA WA CSA 1031
    rs1486315081,2
    --33054827(+) TCAATA/GGTGAG 1 -- ut310--------
    rs92775351,2
    C,F,H--33054861(+) GACCCA/GTATTC 1 -- ut3133Minor allele frequency- G:0.32NS EA NA WA 3592
    rs1421306671,2
    --33054875(+) CAGCAC/GTAATT 1 -- ut310--------
    rs1159913351,2
    F--33054885(+) TCAACA/TTATAC 1 -- ut311Minor allele frequency- T:0.01NA 120
    rs92775361,2
    C,F--33054890(+) ATATAT/CCTTAC 1 -- ut3112Minor allele frequency- C:0.49NA WA CSA EA 505
    rs30976771,2
    C,H--33054924(+) ATTAAG/TAAGTT 1 -- ut315Minor allele frequency- T:0.01NS EA WA 524
    rs92775371,2
    C,F--33055009(+) ATACTA/CCTTAA 1 -- ut319Minor allele frequency- C:0.47WA NA CSA EA 369
    rs92775381,2
    C,F,H--33055047(+) ATCCAG/ATAGAC 1 -- ut3113Minor allele frequency- A:0.46NS EA WA NA CSA 775
    rs92775391,2
    C,F,H--33055079(+) CATTCG/ATCCAC 1 -- ut3111Minor allele frequency- A:0.47EA NS WA NA CSA 637
    rs95012551,2
    C,F,H--33055098(+) GCCTCC/TTGTCT 1 -- ut318Minor allele frequency- T:0.04NS EA WA NA 768
    rs30976781,2
    --33055112(+) TTTTCA/GTACAG 1 -- ut310--------
    rs92775401,2
    C,F,H--33055123(+) ACAGAG/AATGAC 1 -- ut3113Minor allele frequency- A:0.46NS EA WA NA CSA 773
    rs92775411,2
    C,F,H--33055158(+) AATACG/ATGTAG 1 -- ut3112Minor allele frequency- A:0.46NS EA WA NA CSA 781
    rs92803121,2
    C--33055197(+) TTTTT-/CTTAAC 1 -- ut310--------
    rs725005641,2
    C--33055197(+) TTTTTT/CTTAAC 1 -- ut312Minor allele frequency- C:0.00WA CSA 3
    rs92775421,2
    C,F,H--33055247(+) CCTTTC/TGGTCA 1 -- ut3130Minor allele frequency- N:0.00NS EA NA WA CSA 2981
    rs1396101091,2
    C--33055280(+) AAGCT-/TTCTTTTT 1 -- cds10--------
    rs737403091,2
    C--33055288(+) TTTTTT/CGTGTA 1 -- ut313Minor allele frequency- C:0.00WA CSA 5
    rs92775431,2
    C,F,H--33055294(+) GTGTAG/AAGGAT 1 -- ut319Minor allele frequency- A:0.02NS EA WA NA CSA 423
    rs92775441,2
    C--33055308(+) TTCTTT/CACTCC 1 -- ut318Minor allele frequency- C:0.49WA NA CSA EA 367
    rs1402591771,2
    --33055310(+) CTTCAC/TTCCTG 1 -- ut310--------
    rs92775451,2
    C,F,H--33055323(+) ACACAC/TAATCA 1 -- ut3112Minor allele frequency- T:0.48NS EA WA NA CSA 771
    rs92775461,2
    C,F,H--33055346(+) TCTCTT/GATACA 1 -- ut3121Minor allele frequency- G:0.48NS EA WA NA CSA 2323
    rs95012571,2
    C--33055355(+) CATCCA/GGTTGA 1 -- ut315Minor allele frequency- G:0.37WA CSA NA 243
    rs1143945751,2
    F--33055360(+) AGTTGA/GTGCCT 1 -- ut312Minor allele frequency- G:0.05WA EA 238
    rs92775471,2
    C,F,H--33055367(+) GCCTTC/AAGTCT 1 -- ut3110Minor allele frequency- A:0.48NS EA WA NA CSA 657
    rs92775481,2
    C,F,H--33055390(+) ACAAGT/CATCTT 1 -- ut3112Minor allele frequency- C:0.46NS EA WA NA CSA 779
    rs92775491,2
    C,F,A,H--33055419(+) TGGGCG/ACCTGT 1 -- ut3111Minor allele frequency- A:0.42EA NS WA NA CSA 629
    rs1465203901,2
    C--33055471(+) TCTCCC/GCTTGC 1 -- ut310--------
    rs92775501,2
    C,F,A,H--33055487(+) ATATCT/CTCCAT 1 -- ut3122Minor allele frequency- C:0.47NS EA NA WA CSA 2347
    rs92775511,2
    C,A--33055494(+) CCATCT/GGGGGA 1 -- ut318Minor allele frequency- G:0.48WA NA CSA EA 367
    rs1121194171,2
    C--33055499(+) GGGGGA/TCCGGC 1 -- ut313Minor allele frequency- T:0.03NA WA 240
    rs92775521,2
    C,F,H--33055501(+) GGGACC/TGGCTT 1 -- ut317Minor allele frequency- T:0.13EA NS NA WA 510
    rs92775531,2
    C,F,A,H--33055516(+) CAATTC/TCAGGA 1 -- ut3115Minor allele frequency- T:0.46NS EA WA NA CSA 1195
    rs92775541,2
    C,F,H--33055538(+) GAAGGC/TACAGA 1 -- ut3130Minor allele frequency- T:0.49NS EA NA WA CSA 3253
    rs95012591,2
    C,F,H--33055551(+) TGGGCG/ATCACT 1 -- ut3111Minor allele frequency- A:0.28NS EA WA NA CSA 651
    rs92775551,2
    C,F,H--33055605(+) GGACTG/AAGTCA 1 -- ut3126Minor allele frequency- A:0.42NS EA NA WA CSA 2769
    rs1489695281,2
    C--33055665(+) CATAA-/TCTTCTTA 1 -- cds10--------
    rs1121709641,2
    C--33055720(+) TTTATC/-CCCTG 1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs604602111,2
    C--33055721(+) TTATC-/CCCTGA 1 -- ut310--------
    rs1924496831,2
    --33055725(+) TCCCTG/TATCAG 1 -- ut310--------
    rs31289631,2
    C,F,O,A,H--33055780(+) TTTTGC/TGTAGT 1 -- ut3129Minor allele frequency- T:0.48NS EA NA WA CSA 2905
    rs31289641,2
    C,F,O,A--33055818(+) GGAAGG/ACAGTA 1 -- ut3112Minor allele frequency- A:0.49NA WA CSA EA 507
    rs2020734951,2
    --33055842(+) GACCC-/TTTA  
            
    TCTGT
    1 -- ut310--------
    rs58754361,2
    C--33055844(+) CCCTTTATC/-  
            
    TGTCT
    1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs773394911,2
    C--33055845(+) CCTTTA/GTCTGT 1 -- ut310--------
    rs31289651,2
    C,F,A,H--33055899(+) ATGCAG/ACATAA 1 -- ut3124Minor allele frequency- A:0.12NS EA NA WA 2902
    rs1165082341,2
    C,F--33055920(+) ATTTCA/GATCCA 1 -- ut311Minor allele frequency- G:0.03WA 118
    rs31289661,2
    C,F,A,H--33055946(+) AAGGAG/AGTCAT 1 -- ut3121Minor allele frequency- A:0.12NS EA NA WA 2762
    rs1409757031,2
    --33056016(+) TAAATC/GCTACC 1 -- ut310--------
    rs31172291,2
    C,F,A,H--33056069(-) TCTGAC/TTGGAT 1 -- ut3128Minor allele frequency- T:0.33NS EA NA WA 3356
    rs31289671,2
    C,F,A,H--33056097(+) TTGTCA/G/TCCTGT 2 -- ut3122NS EA WA NA 2708
    rs1501470341,2
    C--33056120(+) GGTTAG/TGGCAG 1 -- ut310--------
    rs1386058981,2
    C--33056128(+) CAGTAC/TCCCGA 1 -- ut310--------
    rs586490231,2
    C--33056146(+) GAACAA/GTCTCT 1 -- ut314Minor allele frequency- G:0.26WA CSA NA 242
    rs92803171,2
    C--33056158(+) GACTA-/ACACTTG 1 -- ut310--------
    rs31301861,2
    C,F,A,H--33056207(+) AGGAAC/TAGGAT 1 -- ut3118Minor allele frequency- T:0.32NS EA WA NA 2342
    rs31289681,2
    C,F,A,H--33056253(+) AGGAAT/AGTCCC 1 -- ut3119Minor allele frequency- A:0.37NS EA NA WA 1580
    rs1489511341,2
    C--33056256(+) AATGTC/GCCTGG 1 -- ut310--------
    rs31289691,2
    C--33056374(+) AGACAA/GGAGCT 1 -- ut313Minor allele frequency- G:0.03NA WA 240
    rs94618321,2
    C,F,H--33056384(+) TGAGAG/AACCAT 1 -- ut319Minor allele frequency- A:0.24NS EA WA CSA NA 647
    rs114402641,2
    C--33056396(+) AAACTG/-GGGAC 1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs92824131,2
    C--33056397(+) CTGGG-/GACCAC 1 -- ut310--------
    rs31301871,2
    C--33056405(+) ACCACC/TTTGTC 1 -- ut315Minor allele frequency- T:0.30NA WA EA 362
    rs31172281,2
    C,F,O,A,H--33056435(-) TCTATC/AAATAT 1 -- ut3126Minor allele frequency- A:0.48NS EA WA NA CSA 2937