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Aliases for HLA-DPB1 Gene

Aliases for HLA-DPB1 Gene

  • Major Histocompatibility Complex, Class II, DP Beta 1 2 3 5
  • HLA Class II Histocompatibility Antigen, DP(W4) Beta Chain 3 4
  • MHC Class II Antigen DPB1 3 4
  • HLA-DP1B 3 4
  • HLA Class II Histocompatibility Antigen, DP Beta 1 Chain 3
  • HLA-DP Histocompatibility Type, Beta-1 Subunit 3
  • MHC Class II HLA-DP-Beta-1 3
  • MHC HLA DPB1 3
  • HLA-DPB 3
  • HLA-DP 3
  • DPB1 3

External Ids for HLA-DPB1 Gene

Previous HGNC Symbols for HLA-DPB1 Gene

  • HLA-DP1B

Previous GeneCards Identifiers for HLA-DPB1 Gene

  • GC06P033046
  • GC06P033090
  • GC06P033151
  • GC06P032786

Summaries for HLA-DPB1 Gene

Entrez Gene Summary for HLA-DPB1 Gene

  • HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-DPB1 Gene

HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1) is a Protein Coding gene. Diseases associated with HLA-DPB1 include Chronic Beryllium Disease and Wegener Granulomatosis. Among its related pathways are G-protein signaling N-RAS regulation pathway and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include peptide antigen binding. An important paralog of this gene is HLA-DQB1.

UniProtKB/Swiss-Prot for HLA-DPB1 Gene

  • Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Gene Wiki entry for HLA-DPB1 Gene

Additional gene information for HLA-DPB1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-DPB1 Gene

Genomics for HLA-DPB1 Gene

GeneHancer (GH) Regulatory Elements for HLA-DPB1 Gene

Promoters and enhancers for HLA-DPB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I033070 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 576.5 -2.3 -2263 6.6 HDGF PKNOX1 ATF1 SMAD1 RB1 YBX1 KLF5 IRF4 RFX5 ZNF207 HLA-DPA1 HLA-DPB1 HLA-DQB1 HLA-DQA2 HLA-DOB HLA-DRB1 HLA-DOA HLA-DQB2 HLA-DMA HLA-DMB
GH06I033079 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 51.2 +4.8 4816 2 PKNOX1 SIN3A GLI4 ZNF2 ZNF121 GLIS2 ZNF213 ZNF143 KLF13 SP3 HLA-DPA1 RPL32P1 GC06P033079 HLA-DPB1 HLA-DPB2 PHF1 RING1 RXRB HLA-DMA HLA-DPA3
GH06I033082 Enhancer 0.8 ENCODE dbSUPER 60.8 +7.0 6973 0.2 HDGF CTCF ZBTB6 TRIM22 CEBPB REST CEBPG RAD21 NR2F2 RFX5 HLA-DPB1 HLA-DPA1 HLA-DPA2 GC06M032900
GH06I033092 Enhancer 0.9 ENCODE dbSUPER 46.4 +16.3 16253 0.2 HDGF SMARCA5 CTCF USF1 MAX TRIM22 SIN3A USF2 REST EBF1 HLA-DPB1 COL11A2 RNY4P10 RXRB SLC39A7 HSD17B8 MIR219A1 HLA-DPA2 HLA-DPA1 GC06M032900
GH06I033016 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 27.8 -57.1 -57059 5 MAX EBF1 CEBPG RAD21 RFX5 YY1 RELA POLR2A ETV6 IKZF2 HLA-DQA2 HLA-DPB1 HLA-DPA1 HLA-DQB2 HLA-DMA HLA-DMB HLA-DQB1 HLA-DOA HSD17B8 RPL32P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HLA-DPB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HLA-DPB1 gene promoter:

Genomic Locations for HLA-DPB1 Gene

Genomic Locations for HLA-DPB1 Gene
chr6:33,075,926-33,089,696
(GRCh38/hg38)
Size:
13,771 bases
Orientation:
Plus strand
chr6:33,043,703-33,057,473
(GRCh37/hg19)

Genomic View for HLA-DPB1 Gene

Genes around HLA-DPB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-DPB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-DPB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-DPB1 Gene

  • Protein details for HLA-DPB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04440-DPB1_HUMAN
    Recommended name:
    HLA class II histocompatibility antigen, DP beta 1 chain
    Protein Accession:
    P04440
    Secondary Accessions:
    • A0PFJ7
    • A5I886
    • A8YPB3
    • B5U8B4
    • B7VF80
    • B7VF87
    • B8ZX68
    • B8ZYT0
    • B9W5S8
    • B9W6F7
    • B9W6F9
    • C0MPP5
    • C0MPQ2
    • C0MPQ3
    • C0MPQ5
    • C0MPQ6
    • C0MPQ7
    • C4R9J5
    • C5IZL1
    • O00259
    • O19698
    • O19700
    • O19702
    • O19749
    • O46884
    • O77952
    • O98215
    • O98216
    • O98217
    • O98218
    • O98219
    • O98222
    • O98223
    • P01916
    • P04232
    • P13763
    • P79493
    • P79608
    • Q0P0L4
    • Q0ZFN3
    • Q14279
    • Q27S71
    • Q29682
    • Q29684
    • Q29698
    • Q29714
    • Q29775
    • Q29776
    • Q29778
    • Q29779
    • Q29781
    • Q29827
    • Q29828
    • Q29879
    • Q29880
    • Q29898
    • Q29977
    • Q2MGW3
    • Q30015
    • Q30031
    • Q30032
    • Q30033
    • Q30034
    • Q30050
    • Q30051
    • Q30052
    • Q30053
    • Q30054
    • Q30055
    • Q30174
    • Q4GY31
    • Q4JHD8
    • Q5ENE0
    • Q5ENE1
    • Q5ENW3
    • Q5EP46
    • Q5EP47
    • Q5EP49
    • Q5EP51
    • Q5EP52
    • Q5EP53
    • Q5EP56
    • Q5I4H8
    • Q5I4H9
    • Q5ISH4
    • Q5ISH5
    • Q5SQ73
    • Q5STP2
    • Q5YLA6
    • Q6IVX1
    • Q6LBX2
    • Q6LBX3
    • Q6LBX4
    • Q6LBX5
    • Q6LBX6
    • Q6LBX7
    • Q6PWX6
    • Q6TAS4
    • Q714U1
    • Q714U2
    • Q7YQ10
    • Q860Z7
    • Q8HWL7
    • Q8HWT5
    • Q8SNC4
    • Q95HC1
    • Q95IT7
    • Q95IT8
    • Q9BD13
    • Q9GIM2
    • Q9GIM4
    • Q9GIX6
    • Q9GJ41
    • Q9MY67
    • Q9TNT7
    • Q9TQE2
    • Q9XS11
    • Q9XS12

    Protein attributes for HLA-DPB1 Gene

    Size:
    258 amino acids
    Molecular mass:
    29159 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.
    SequenceCaution:
    • Sequence=AAQ12564.1; Type=Frameshift; Positions=39; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HLA-DPB1 Gene

neXtProt entry for HLA-DPB1 Gene

Post-translational modifications for HLA-DPB1 Gene

Other Protein References for HLA-DPB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HLA-DPB1 Gene

Domains & Families for HLA-DPB1 Gene

Gene Families for HLA-DPB1 Gene

Graphical View of Domain Structure for InterPro Entry

P04440

UniProtKB/Swiss-Prot:

DPB1_HUMAN :
  • Belongs to the MHC class II family.
Family:
  • Belongs to the MHC class II family.
genes like me logo Genes that share domains with HLA-DPB1: view

Function for HLA-DPB1 Gene

Molecular function for HLA-DPB1 Gene

GENATLAS Biochemistry:
HLA-DP,beta chain
UniProtKB/Swiss-Prot Function:
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Phenotypes From GWAS Catalog for HLA-DPB1 Gene

Gene Ontology (GO) - Molecular Function for HLA-DPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042605 peptide antigen binding IDA 20356827
genes like me logo Genes that share ontologies with HLA-DPB1: view
genes like me logo Genes that share phenotypes with HLA-DPB1: view

Human Phenotype Ontology for HLA-DPB1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HLA-DPB1 Gene

Localization for HLA-DPB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-DPB1 Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HLA-DPB1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
lysosome 5
golgi apparatus 5
endosome 5
extracellular 2
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HLA-DPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane TAS --
GO:0005768 endosome IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with HLA-DPB1: view

Pathways & Interactions for HLA-DPB1 Gene

genes like me logo Genes that share pathways with HLA-DPB1: view

Interacting Proteins for HLA-DPB1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000408146%0d%0a9606.ENSP00000393566%0d%0a9606.ENSP00000387875%0d%0a9606.ENSP00000265148%0d%0a9606.ENSP00000272102%0d%0a9606.ENSP00000220003%0d%0a
Selected Interacting proteins: P04440-DPB1_HUMAN ENSP00000408146 for HLA-DPB1 Gene via IID STRING UniProtKB MINT

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
HLA-DRB1
RTN4

Gene Ontology (GO) - Biological Process for HLA-DPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA --
GO:0006955 immune response IEA --
GO:0019882 antigen processing and presentation IEA --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IMP,TAS --
genes like me logo Genes that share ontologies with HLA-DPB1: view

No data available for SIGNOR curated interactions for HLA-DPB1 Gene

Drugs & Compounds for HLA-DPB1 Gene

(1) Drugs for HLA-DPB1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved, Vet_approved Pharma Channel blocker 1232

(4) Additional Compounds for HLA-DPB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HLA-DPB1: view

Transcripts for HLA-DPB1 Gene

Unigene Clusters for HLA-DPB1 Gene

Major histocompatibility complex, class II, DP beta 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-DPB1 Gene

No ASD Table

Relevant External Links for HLA-DPB1 Gene

GeneLoc Exon Structure for
HLA-DPB1
ECgene alternative splicing isoforms for
HLA-DPB1

Expression for HLA-DPB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HLA-DPB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-DPB1 Gene

This gene is overexpressed in Spleen (x5.0) and Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for HLA-DPB1 Gene

This gene is overexpressed in Skin (24.3), Breast (8.0), and Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HLA-DPB1 Gene



Protein tissue co-expression partners for HLA-DPB1 Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for HLA-DPB1 Gene:

Hs.485130

Evidence on tissue expression from TISSUES for HLA-DPB1 Gene

  • Blood(4.7)
  • Spleen(4.5)
  • Lung(4)
  • Bone marrow(2.7)
  • Nervous system(2.5)
  • Intestine(2.2)
  • Kidney(2.2)
  • Pancreas(2.2)
  • Lymph node(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-DPB1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • nervous
  • respiratory
  • skeleton
  • urinary
Organs:
Head and neck:
  • brain
  • ear
  • eye
  • face
  • head
  • larynx
  • mouth
  • neck
  • nose
  • pituitary gland
  • sinus
  • skull
Thorax:
  • bronchus
  • esophagus
  • heart
  • lung
  • trachea
Abdomen:
  • kidney
  • stomach
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • coagulation system
  • peripheral nerve
  • peripheral nervous system
  • red blood cell
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with HLA-DPB1: view

No data available for mRNA Expression by UniProt/SwissProt for HLA-DPB1 Gene

Orthologs for HLA-DPB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HLA-DPB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PATR-DPB1 34 33
  • 97.55 (n)
OneToOne
cow
(Bos Taurus)
Mammalia BOLA-DRB3 34
  • 56 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia HLA-DPB1 34
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 50 (a)
ManyToMany
chicken
(Gallus gallus)
Aves BLB3 33
  • 65.72 (n)
Species where no ortholog for HLA-DPB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HLA-DPB1 Gene

ENSEMBL:
Gene Tree for HLA-DPB1 (if available)
TreeFam:
Gene Tree for HLA-DPB1 (if available)

Paralogs for HLA-DPB1 Gene

(114) SIMAP similar genes for HLA-DPB1 Gene using alignment to 265 proteins:

genes like me logo Genes that share paralogs with HLA-DPB1: view

Variants for HLA-DPB1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DPB1 Gene

DPB1_HUMAN-P04440
The following alleles of HLA-DPB1 are known: DPB1*01:01, DPB1*01:02, DPB1*02:01, DPB1*02:02, DPB1*02:03, DPB1*03:01, DPB1*03:02, DPB1*04:01, DPB1*04:02, DPB1*04:03, DPB1*05:01, DPB1*05:02, DPB1*06:01, DPB1*06:02, DPB1*08:01, DPB1*08:02, DPB1*09:01, DPB1*09:02, DPB1*10:01, DPB1*10:02, DPB1*11:01, DPB1*11:02, DPB1*13:01, DPB1*13:02, DPB1*14:01, DPB1*14:02, DPB1*15:01, DPB1*15:02, DPB1*16:01, DPB1*16:02, DPB1*17:01, DPB1*17:02, DPB1*18:01, DPB1*18:02, DPB1*19:01, DPB1*19:02, DPB1*20:01, DPB1*20:02, DPB1*21:01, DPB1*21:02, DPB1*22:01, DPB1*22:02, DPB1*23:01, DPB1*24:01, DPB1*24:02, DPB1*25:01, DPB1*25:02, DPB1*26:01, DPB1*26:02, DPB1*27:01, DPB1*28:01, DPB1*29:01, DPB1*30:01, DPB1*31:01, DPB1*32:01, DPB1*33:01, DPB1*34:01, DPB1*35:01, DPB1*36:01, DPB1*37:01, DPB1*38:01, DPB1*39:01, DPB1*40:01, DPB1*41:01, DPB1*44:01, DPB1*45:01, DPB1*46:01, DPB1*47:01, DPB1*48:01, DPB1*49:01, DPB1*50:01, DPB1*51:01, DPB1*52:01, DPB1*53:01, DPB1*54:01, DPB1*55:01, DPB1*56:01, DPB1*57:01, DPB1*58:01, DPB1*59:01, DPB1*60:01, DPB1*62:01, DPB1*63:01, DPB1*65:01, DPB1*66:01, DPB1*67:01, DPB1*68:01, DPB1*69:01, DPB1*70:01, DPB1*71:01, DPB1*72:01, DPB1*73:01, DPB1*74:01, DPB1*75:01, DPB1*76:01, DPB1*77:01, DPB1*78:01, DPB1*79:01, DPB1*80:01, DPB1*81:01, DPB1*82:01, DPB1*83:01, DPB1*84:01, DPB1*85:01, DPB1*86:01, DPB1*87:01, DPB1*88:01, DPB1*89:01, DPB1*90:01, DPB1*91:01, DPB1*92:01, DPB1*93:01, DPB1*94:01, DPB1*95:01, DPB1*96:01, DPB1*97:01, DPB1*98:01 and DPB1*99:01. The sequence shown is that of DPB1*04:01.

Sequence variations from dbSNP and Humsavar for HLA-DPB1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1042140 risk-factor, Beryllium disease, chronic, susceptibility to 33,080,863(+) A/C/G/T coding_sequence_variant, missense_variant, stop_gained
rs1000127410 -- 33,078,551(+) A/C intron_variant
rs1000254634 -- 33,087,415(+) T/G 3_prime_UTR_variant
rs1000357828 -- 33,076,538(+) C/T intron_variant
rs1000705128 -- 33,087,974(+) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for HLA-DPB1 Gene

Variant ID Type Subtype PubMed ID
dgv1000e201 CNV deletion 23290073
dgv1040n67 CNV loss 20364138
dgv1041n67 CNV loss 20364138
dgv1042n67 CNV loss 20364138
esv1006913 CNV gain 20482838
esv22467 CNV loss 19812545
esv2731879 CNV deletion 23290073
esv3570995 CNV loss 25503493
nsv1024429 CNV loss 25217958
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1119076 CNV deletion 24896259
nsv462892 CNV loss 19166990
nsv516221 CNV loss 19592680
nsv602818 CNV loss 21841781
nsv602823 CNV loss 21841781
nsv602824 CNV loss 21841781
nsv819171 CNV loss 19587683
nsv823645 CNV loss 20364138
nsv823656 CNV loss 20364138
nsv970108 CNV duplication 23825009

Variation tolerance for HLA-DPB1 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 28.14; 99.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HLA-DPB1 Gene

Human Gene Mutation Database (HGMD)
HLA-DPB1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HLA-DPB1

Disorders for HLA-DPB1 Gene

MalaCards: The human disease database

(22) MalaCards diseases for HLA-DPB1 Gene - From: HGMD, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chronic beryllium disease
  • berylliosis
wegener granulomatosis
  • wg
beryllium disease
  • acute berylliosis
juvenile rheumatoid arthritis
  • acute juvenile rheumatoid arthritis
posner-schlossman syndrome
  • glaucomatocyclitic crisis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for HLA-DPB1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HLA-DPB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HLA-DPB1 Gene

Publications for HLA-DPB1 Gene

  1. Effect of human leukocyte antigen homozygosity on rubella vaccine-induced humoral and cell-mediated immune responses. (PMID: 19896518) Kennedy RB … Poland GA (Human immunology 2010) 3 22 44 58
  2. Association of the HLA-DPB1*0501 allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders. (PMID: 19140826) Matsushita T … Kira J (Tissue antigens 2009) 3 22 44 58
  3. Analysis of maternal-offspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes. (PMID: 19143818) Bronson PG … Diabetes Genetics Consortium (Diabetes, obesity & metabolism 2009) 3 22 44 58
  4. HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis. (PMID: 19165231) Kominami S … Kimura A (Journal of human genetics 2009) 3 22 44 58
  5. Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controls. (PMID: 18486765) Noble JA … Erlich HA (Human immunology 2008) 3 22 44 58

Products for HLA-DPB1 Gene

Sources for HLA-DPB1 Gene

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