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Aliases for HLA-DPB1 Gene

Aliases for HLA-DPB1 Gene

  • Major Histocompatibility Complex, Class II, DP Beta 1 2 3
  • HLA Class II Histocompatibility Antigen, DP(W4) Beta Chain 3 4
  • MHC Class II Antigen DPB1 3 4
  • HLA-DP1B 3 4
  • Major Histocompatibility Complex Class II Antigen Beta Chain 3
  • HLA Class II Histocompatibility Antigen, DP Beta 1 Chain 3
  • HLA-DP Histocompatibility Type, Beta-1 Subunit 3
  • MHC Class II Antigen DP Beta 1 Chain 3
  • Beta1 Domain MHC Class II HLA DPB 3
  • MHC Class II Antigen Beta Chain 3
  • MHC Class II Antigen DPbeta1 3
  • MHC Class II HLA-DP-Beta-1 3
  • Class II HLA Beta Chain 3
  • MHC Class II HLA-DRB1 3
  • HLA DP14-Beta Chain 3
  • MHC HLA DPB1 3
  • HLA-DPB 3
  • HLA-DP 3
  • DPB1 3

External Ids for HLA-DPB1 Gene

Previous HGNC Symbols for HLA-DPB1 Gene

  • HLA-DP1B

Previous GeneCards Identifiers for HLA-DPB1 Gene

  • GC06P033046
  • GC06P033090
  • GC06P033151
  • GC06P032786

Summaries for HLA-DPB1 Gene

Entrez Gene Summary for HLA-DPB1 Gene

  • HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-DPB1 Gene

HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1) is a Protein Coding gene. Diseases associated with HLA-DPB1 include chronic berylliosis and wegener granulomatosis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Epstein-Barr virus infection. An important paralog of this gene is HLA-DMA.

UniProtKB/Swiss-Prot for HLA-DPB1 Gene

  • Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading

Gene Wiki entry for HLA-DPB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-DPB1 Gene

Genomics for HLA-DPB1 Gene

Regulatory Elements for HLA-DPB1 Gene

Genomic Location for HLA-DPB1 Gene

Start:
33,075,926 bp from pter
End:
33,089,696 bp from pter
Size:
13,771 bases
Orientation:
Plus strand

Genomic View for HLA-DPB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HLA-DPB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-DPB1 Gene

  • Protein details for HLA-DPB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04440-DPB1_HUMAN
    Recommended name:
    HLA class II histocompatibility antigen, DP beta 1 chain
    Protein Accession:
    P04440
    Secondary Accessions:
    • A0PFJ7
    • A5I886
    • A8YPB3
    • B5U8B4
    • B7VF80
    • B7VF87
    • B8ZX68
    • B8ZYT0
    • B9W5S8
    • B9W6F7
    • B9W6F9
    • C0MPP5
    • C0MPQ2
    • C0MPQ3
    • C0MPQ5
    • C0MPQ6
    • C0MPQ7
    • C4R9J5
    • C5IZL1
    • O00259
    • O19698
    • O19700
    • O19702
    • O19749
    • O46884
    • O77952
    • O98215
    • O98216
    • O98217
    • O98218
    • O98219
    • O98222
    • O98223
    • P01916
    • P04232
    • P13763
    • P79493
    • P79608
    • Q0P0L4
    • Q0ZFN3
    • Q14279
    • Q27S71
    • Q29682
    • Q29684
    • Q29698
    • Q29714
    • Q29775
    • Q29776
    • Q29778
    • Q29779
    • Q29781
    • Q29827
    • Q29828
    • Q29879
    • Q29880
    • Q29898
    • Q29977
    • Q2MGW3
    • Q30015
    • Q30031
    • Q30032
    • Q30033
    • Q30034
    • Q30050
    • Q30051
    • Q30052
    • Q30053
    • Q30054
    • Q30055
    • Q30174
    • Q4GY31
    • Q4JHD8
    • Q5ENE0
    • Q5ENE1
    • Q5ENW3
    • Q5EP46
    • Q5EP47
    • Q5EP49
    • Q5EP51
    • Q5EP52
    • Q5EP53
    • Q5EP56
    • Q5I4H8
    • Q5I4H9
    • Q5ISH4
    • Q5ISH5
    • Q5SQ73
    • Q5STP2
    • Q5YLA6
    • Q6IVX1
    • Q6LBX2
    • Q6LBX3
    • Q6LBX4
    • Q6LBX5
    • Q6LBX6
    • Q6LBX7
    • Q6PWX6
    • Q6TAS4
    • Q714U1
    • Q714U2
    • Q7YQ10
    • Q860Z7
    • Q8HWL7
    • Q8HWT5
    • Q8SNC4
    • Q95HC1
    • Q95IT7
    • Q95IT8
    • Q9BD13
    • Q9GIM2
    • Q9GIM4
    • Q9GIX6
    • Q9GJ41
    • Q9MY67
    • Q9TNT7
    • Q9TQE2
    • Q9XS11
    • Q9XS12

    Protein attributes for HLA-DPB1 Gene

    Size:
    258 amino acids
    Molecular mass:
    29159 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides
    SequenceCaution:
    • Sequence=AAQ12564.1; Type=Frameshift; Positions=39; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HLA-DPB1 Gene

neXtProt entry for HLA-DPB1 Gene

Proteomics data for HLA-DPB1 Gene at MOPED

Post-translational modifications for HLA-DPB1 Gene

  • Glycosylation at Asn48
  • Modification sites at PhosphoSitePlus

Other Protein References for HLA-DPB1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HLA-DPB1 Gene

Domains for HLA-DPB1 Gene

Gene Families for HLA-DPB1 Gene

HGNC:
  • C1SET :Immunoglobulin superfamily / C1-set domain containing
  • HLA :Histocompatibility complex

Graphical View of Domain Structure for InterPro Entry

P04440

UniProtKB/Swiss-Prot:

DPB1_HUMAN :
  • P04440
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Family:
  • Belongs to the MHC class II family.
genes like me logo Genes that share domains with HLA-DPB1: view

Function for HLA-DPB1 Gene

Molecular function for HLA-DPB1 Gene

GENATLAS Biochemistry: HLA-DP,beta chain
UniProtKB/Swiss-Prot Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading

Gene Ontology (GO) - Molecular Function for HLA-DPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042605 peptide antigen binding IDA 20356827
genes like me logo Genes that share ontologies with HLA-DPB1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HLA-DPB1 Gene

Localization for HLA-DPB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-DPB1 Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HLA-DPB1 Gene COMPARTMENTS Subcellular localization image for HLA-DPB1 gene
Compartment Confidence
endoplasmic reticulum 5
endosome 5
lysosome 5
plasma membrane 5
vacuole 5
golgi apparatus 4
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for HLA-DPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005765 lysosomal membrane TAS --
GO:0005768 endosome --
GO:0005886 plasma membrane TAS --
GO:0009986 cell surface IMP 20356827
genes like me logo Genes that share ontologies with HLA-DPB1: view

Pathways for HLA-DPB1 Gene

genes like me logo Genes that share pathways with HLA-DPB1: view

Gene Ontology (GO) - Biological Process for HLA-DPB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II --
GO:0006955 immune response --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0019882 antigen processing and presentation --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with HLA-DPB1: view

Compounds for HLA-DPB1 Gene

(4) Novoseek inferred chemical compound relationships for HLA-DPB1 Gene

Compound -log(P) Hits PubMed IDs
dpa 1 96.1 24
beryllium 66.1 6
oligonucleotide 30.5 5
glutamate 0 1
genes like me logo Genes that share compounds with HLA-DPB1: view

Transcripts for HLA-DPB1 Gene

Unigene Clusters for HLA-DPB1 Gene

Major histocompatibility complex, class II, DP beta 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HLA-DPB1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-DPB1 Gene

No ASD Table

Relevant External Links for HLA-DPB1 Gene

GeneLoc Exon Structure for
HLA-DPB1
ECgene alternative splicing isoforms for
HLA-DPB1

Expression for HLA-DPB1 Gene

mRNA expression in normal human tissues for HLA-DPB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-DPB1 Gene

This gene is overexpressed in Spleen (5.0) and Whole Blood (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HLA-DPB1 Gene

SOURCE GeneReport for Unigene cluster for HLA-DPB1 Gene Hs.485130

genes like me logo Genes that share expressions with HLA-DPB1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HLA-DPB1 Gene

Orthologs for HLA-DPB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HLA-DPB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PATR-DPB1 35
  • 97.55 (n)
  • 95.74 (a)
PATR-DPB1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BOLA-DRB3 36
  • 56 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia HLA-DPB1 36
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
ManyToMany
chicken
(Gallus gallus)
Aves BLB3 35
  • 65.72 (n)
  • 54.03 (a)
Species with no ortholog for HLA-DPB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HLA-DPB1 Gene

ENSEMBL:
Gene Tree for HLA-DPB1 (if available)
TreeFam:
Gene Tree for HLA-DPB1 (if available)

Paralogs for HLA-DPB1 Gene

Selected SIMAP similar genes for HLA-DPB1 Gene using alignment to 265 proteins:

Pseudogenes.org Pseudogenes for HLA-DPB1 Gene

genes like me logo Genes that share paralogs with HLA-DPB1: view

Variants for HLA-DPB1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DPB1 Gene

P04440-DPB1_HUMAN
The following alleles of HLA-DPB1 are known: DPB1*01:01, DPB1*01:02, DPB1*02:01, DPB1*02:02, DPB1*02:03, DPB1*03:01, DPB1*03:02, DPB1*04:01, DPB1*04:02, DPB1*04:03, DPB1*05:01, DPB1*05:02, DPB1*06:01, DPB1*06:02, DPB1*08:01, DPB1*08:02, DPB1*09:01, DPB1*09:02, DPB1*10:01, DPB1*10:02, DPB1*11:01, DPB1*11:02, DPB1*13:01, DPB1*13:02, DPB1*14:01, DPB1*14:02, DPB1*15:01, DPB1*15:02, DPB1*16:01, DPB1*16:02, DPB1*17:01, DPB1*17:02, DPB1*18:01, DPB1*18:02, DPB1*19:01, DPB1*19:02, DPB1*20:01, DPB1*20:02, DPB1*21:01, DPB1*21:02, DPB1*22:01, DPB1*22:02, DPB1*23:01, DPB1*24:01, DPB1*24:02, DPB1*25:01, DPB1*25:02, DPB1*26:01, DPB1*26:02, DPB1*27:01, DPB1*28:01, DPB1*29:01, DPB1*30:01, DPB1*31:01, DPB1*32:01, DPB1*33:01, DPB1*34:01, DPB1*35:01, DPB1*36:01, DPB1*37:01, DPB1*38:01, DPB1*39:01, DPB1*40:01, DPB1*41:01, DPB1*44:01, DPB1*45:01, DPB1*46:01, DPB1*47:01, DPB1*48:01, DPB1*49:01, DPB1*50:01, DPB1*51:01, DPB1*52:01, DPB1*53:01, DPB1*54:01, DPB1*55:01, DPB1*56:01, DPB1*57:01, DPB1*58:01, DPB1*59:01, DPB1*60:01, DPB1*62:01, DPB1*63:01, DPB1*65:01, DPB1*66:01, DPB1*67:01, DPB1*68:01, DPB1*69:01, DPB1*70:01, DPB1*71:01, DPB1*72:01, DPB1*73:01, DPB1*74:01, DPB1*75:01, DPB1*76:01, DPB1*77:01, DPB1*78:01, DPB1*79:01, DPB1*80:01, DPB1*81:01, DPB1*82:01, DPB1*83:01, DPB1*84:01, DPB1*85:01, DPB1*86:01, DPB1*87:01, DPB1*88:01, DPB1*89:01, DPB1*90:01, DPB1*91:01, DPB1*92:01, DPB1*93:01, DPB1*94:01, DPB1*95:01, DPB1*96:01, DPB1*97:01, DPB1*98:01 and DPB1*99:01. The sequence shown is that of DPB1*04:01

Sequence variations from dbSNP and Humsavar for HLA-DPB1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs928 -- 33,086,775(+) CATGA(C/G)TGTTT utr-variant-3-prime
rs929 -- 33,086,842(+) TAGTA(A/G)ACAGT utr-variant-3-prime, downstream-variant-500B
rs930 -- 33,086,879(+) GTTTA(A/C)ACATA utr-variant-3-prime, downstream-variant-500B
rs931 -- 33,086,773(+) AACAT(A/G)ACTGT utr-variant-3-prime
rs932 -- 33,086,809(+) AAATC(A/G)TCTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HLA-DPB1 Gene

Variant ID Type Subtype PubMed ID
nsv885754 CNV Gain 21882294
esv22467 CNV Loss 19812545
nsv885759 CNV Loss 21882294
nsv823645 CNV Loss 20364138
esv1006913 CNV Gain 20482838
esv2731879 CNV Deletion 23290073
dgv1040n67 CNV Loss 20364138
nsv819171 CNV Loss 19587683
nsv823656 CNV Loss 20364138
dgv1041n67 CNV Loss 20364138
dgv1042n67 CNV Loss 20364138
dgv1047e201 CNV Deletion 23290073
nsv462892 CNV Loss 19166990
nsv516221 CNV Loss 19592680
dgv6828n71 CNV Loss 21882294

Relevant External Links for HLA-DPB1 Gene

HapMap Linkage Disequilibrium report
HLA-DPB1
Human Gene Mutation Database (HGMD)
HLA-DPB1
Locus Specific Mutation Databases (LSDB)
HLA-DPB1

Disorders for HLA-DPB1 Gene

(10) Novoseek inferred disease relationships for HLA-DPB1 Gene

Disease -log(P) Hits PubMed IDs
beryllium disease chronic 77.6 3
genetic susceptibility 52.7 5
arthritis juvenile rheumatoid 40.5 1
diabetes mellitus insulin-dependent 32.3 3
myasthenia gravis 18.1 2

Relevant External Links for HLA-DPB1

Genetic Association Database (GAD)
HLA-DPB1
Human Genome Epidemiology (HuGE) Navigator
HLA-DPB1
genes like me logo Genes that share disorders with HLA-DPB1: view

No data available for UniProtKB/Swiss-Prot for HLA-DPB1 Gene

Publications for HLA-DPB1 Gene

  1. Genetic susceptibility to breast cancer: HLA DQB*03032 and HLA DRB1*11 may represent protective alleles. (PMID: 11027344) Chaudhuri S. … Pillai S. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 23 48
  2. Two new HLA DPB1 alleles identified by sequence-based typing: DPB1*8201 and DPB1*8301. (PMID: 11169249) Voorter C. … van den Berg-Loonen E. (Tissue Antigens 2000) 3 4 23
  3. HLA class I and class II allele and haplotype diversity in Martinicans. (PMID: 11285127) Bera O. … Semana G. (Tissue Antigens 2001) 3 23 48
  4. HLA-DPA1 and DPB1 polymorphism in four Pacific Islands populations determined by sequencing based typing. (PMID: 11556979) Velickovic Z.M. … Carter J.M. (Tissue Antigens 2001) 3 23 48
  5. [Sequencing-based typing of HLA-DPB1 and DQB1 exon 2 in patients with type 1 diabetes mellitus]. (PMID: 11592043) Zhang S. … Jiang Z. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2001) 3 23 48

Products for HLA-DPB1 Gene

Sources for HLA-DPB1 Gene

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