HLA-DPB1 Gene
protein-coding GIFtS: 60
GCID: GC06P033043
|
|
major histocompatibility complex, class II, DP beta 1
(Previous symbol: HLA-DP1B)
| |
Aliases
for HLA-DPB1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Major Histocompatibility Complex, Class II, DP Beta 11 2 | | HLA-DP Histocompatibility Type, Beta-1 Subunit2 | | HLA-DP1B1 2 3 | | Major Histocompatibility Complex Class II Antigen Beta Chain2 | | HLA Class II Histocompatibility Antigen, DP(W4) Beta Chain2 3 | | Major Histocompatibility Complex Class II HLA DPB1 Protein2 | | MHC Class II Antigen DPB12 3 | | MHC Class II Antigen Beta Chain2 | | DPB12 | | MHC Class II Antigen DP Beta 1 Chain2 | | HLA-DP2 | | MHC Class II Antigen DPbeta12 | | HLA-DPB2 | | MHC Class II HLA-DP-Beta2 | | Beta1 Domain MHC Class II HLA DPB2 | | MHC Class II HLA-DP-Beta-12 | | Class II HLA Beta Chain2 | | MHC Class II HLA-DRB12 | | HLA Class II Histocompatibility Antigen, DP Beta 1 Chain2 | | MHC HLA DPB12 | | HLA DP14-Beta Chain2 | | |
Export aliases for HLA-DPB1 gene to outside databasesPrevious GC identifers: GC06P033046 GC06P033090 GC06P033151 GC06P032786 |
Summaries
for HLA-DPB1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HLA-DPB1:
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of analpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system bypresenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells(APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes thetransmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the betachain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 differentmolecules. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) andpresents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptidesof 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteinsthat access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenousantigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, andfor this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on theirway to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomalcompartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also asource of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In additionto APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents anantigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in theER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigenprocessing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving asmall fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DMvia direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II moleculesuntil primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transportedto the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated byHLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in theregulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis andefficient peptide loading
Gene Wiki entry for HLA-DPB1
|
Genomic Views
for HLA-DPB1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167247.1
- NT_167248.1 NT_167249.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HLA-DPB1 gene promoter:
GR Pbx1a p300 FOXD3 CUTL1 MIF-1 Cdc5 STAT3 GR-alpha Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for HLA-DPB1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DPB1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.3HLA-DPB1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P033043: view genomic region
(about GC identifiers)
Start:
|
33,043,703 bp from pter |
End:
|
33,054,978 bp from pter |
Size:
|
11,276 bases |
Orientation:
|
plus strand |
6 alternative locations:
| Chr6+,ALT_REF_LOCI_3 33,021,645-33,043,948 | Chr6+,ALT_REF_LOCI_6 32,972,757-33,019,613 | Chr6+,ALT_REF_LOCI_1 33,027,107-33,046,670 | | Chr6+,ALT_REF_LOCI_5 32,992,038-33,003,244 | Chr6+,ALT_REF_LOCI_4 33,120,959-33,132,181 | Chr6+,ALT_REF_LOCI_7 33,113,729-33,124,945 | |
|
Proteins
for HLA-DPB1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440 (See
protein sequence)Recommended Name: HLA class II histocompatibility antigen, DP beta 1 chain precursor Size: 258 amino acids; 29159 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmicreticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariantchain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoessequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHCclass II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding ofantigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-passtype I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosomemembrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHCclass II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches thecell membrane for antigen presentation
Sequence caution: Sequence=AAQ12564.1; Type=Frameshift; Positions=39;
1 PDB 3D structure from  and Proteopedia  for HLA-DPB1:3LQZ (3D)
Secondary accessions: A0PFJ7 A5I886 A8YPB3 B5U8B4 B7VF80 B7VF87 B8ZX68 B8ZYT0 B9W5S8 B9W6F7 B9W6F9C0MPP5 C0MPQ2 C0MPQ3 C0MPQ5 C0MPQ6 C0MPQ7 C4R9J5 C5IZL1 O00259 O19698 O19700 O19702 O19749 O46884O77952 O98215 O98216 O98217 O98218 O98219 O98222 O98223 P01916 P04232 P13763 P79493 P79608 Q0P0L4Q0ZFN3 Q14279 Q27S71 Q29682 Q29684 Q29698 Q29714 Q29775 Q29776 Q29778 Q29779 Q29781 Q29827 Q29828Q29879 Q29880 Q29898 Q29977 Q2MGW3 Q30015 Q30031 Q30032 Q30033 Q30034 Q30050 Q30051 Q30052 Q30053Q30054 Q30055 Q30174 Q4GY31 Q4JHD8 Q5ENE0 Q5ENE1 Q5ENW3 Q5EP46 Q5EP47 Q5EP49 Q5EP51 Q5EP52 Q5EP53Q5EP56 Q5I4H8 Q5I4H9 Q5ISH4 Q5ISH5 Q5SQ73 Q5STP2 Q5YLA6 Q6IVX1 Q6LBX2 Q6LBX3 Q6LBX4 Q6LBX5 Q6LBX6Q6LBX7 Q6PWX6 Q6TAS4 Q714U1 Q714U2 Q7YQ10 Q860Z7 Q8HWL7 Q8HWT5 Q8SNC4 Q95HC1 Q95IT7 Q95IT8 Q9BD13Q9GIM2 Q9GIM4 Q9GIX6 Q9GJ41 Q9MY67 Q9TNT7 Q9TQE2 Q9XS11 Q9XS12Explore the universe of human proteins at neXtProt for HLA-DPB1: NX_P04440
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P04440
HLA-DPB1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002112.3
ENSEMBL proteins: ENSP00000408146 ENSP00000389210 ENSP00000412654 ENSP00000399832 ENSP00000439674 Reactome Protein details: P04440
Human Recombinant Protein Products:
Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14): About this table
HLA-DPB1 for ontologies About GeneDecksing
HLA-DPB1 Antibody Products:
Assay Products for HLA-DPB1: |
Protein
Domains /
Families
for HLA-DPB1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HLA-DPB1 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P04440ProtoNet protein and cluster: P04440 3 Blocks protein families: IPB000353 Class II histocompatibility antigen IPB001003 MHC Class II alpha chain IPB003597 Immunoglobulin C-type
UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440Similarity: Belongs to the MHC class II familySimilarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain |
Function
for HLA-DPB1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) andpresents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptidesof 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteinsthat access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenousantigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, andfor this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on theirway to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomalcompartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also asource of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In additionto APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents anantigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in theER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigenprocessing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving asmall fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DMvia direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II moleculesuntil primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transportedto the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated byHLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in theregulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis andefficient peptide loading Genatlas biochemistry entry for HLA-DPB1:HLA-DP,beta chain
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DPB1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DPB1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HLA-DPB1 (NM_002121) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HLA-DPB1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DPB1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DPB1 |
|
Pathways & Interactions
for HLA-DPB1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Allograft rejection | | | 2 | Transport of MHC II:Ii complex along Golgi to TGN | | | 3 | Translocation of ZAP-70 to Immunological synapse | | | 4 | Immune response_NFAT in immune response | | | 5 | Immune response_ICOS pathway in T-helper cell | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 EMD Millipore Pathways for HLA-DPB1 (see all 6)
5/6  GeneGo (Thomson Reuters) Pathways for HLA-DPB1 (see all 6)
5/20 
Reactome Pathways for HLA-DPB1 (see all 20)
5/17 
Kegg Pathways (Kegg details for HLA-DPB1) (see all 17):
HLA-DPB1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLA-DPB1
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
4 Interacting proteins for HLA-DPB1 (P044402, 3 ENSP000004081464) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
-- | -- | | GO:0006955 | immune response |
-- | -- | | GO:0019221 | cytokine-mediated signaling pathway |
TAS | -- | | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
TAS | -- | | GO:0031295 | T cell costimulation |
TAS | -- |
HLA-DPB1 for ontologies About GeneDecksing
|
Drugs & Compounds
for HLA-DPB1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HLA-DPB1 for compounds About GeneDecksing
 Browse Tocris compounds for HLA-DPB1
4 Novoseek chemical compound relationships for HLA-DPB1 gene About this table
Search CenterWatch for drugs/clinical trials and news about HLA-DPB1 / DPB1
|
Transcripts
for HLA-DPB1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HLA-DPB1 gene: NM_002121.5 Unigene Cluster for HLA-DPB1: Major histocompatibility complex, class II, DP beta 1 Hs.485130 [show with all ESTs]Unigene Representative Sequence: NM_00212110 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000418931(uc003ocu.2 uc011dqo.2) ENST00000411942 ENST00000469120
ENST00000471184 ENST00000488575 ENST00000498038 ENST00000428835 ENST00000416804(uc011dqq.1)
ENST00000478189 ENST00000535465(uc011dqn.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DPB1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DPB1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HLA-DPB1 (NM_002121) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HLA-DPB1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DPB1 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-DPB1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HLA-DPB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DPB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DPB1 |
Additional cDNA sequence: AB208978.1 AK291986.1 AK301322.1 AK303153.1 AK313305.1 AY656678.1 AY656679.1 AY656680.1 AY804132.1 AY804133.1 AY804134.1 AY804135.1 AY804136.1 AY804137.1 AY804138.1 AY804139.1 AY804140.1 AY804141.1 AY804142.1 AY804143.1 AY831401.1 AY831402.1 AY831403.1 AY831404.1 BC007963.2 BC013184.1 BC015000.1 BT019780.1 DQ284441.1 FR775798.1 GQ891549.1 HE603611.1 HE603612.1 HE614584.1 HE614585.1 HE614586.1 HE614587.1 HE614588.1 HE614589.1 HE614590.1 HE614591.1 J03041.1 K00409.1 K01615.1 L29173.1 M21886.1 M28200.1 M28201.1 M28202.1 M57466.1 M83664.1 S66883.1 S79786.1 X00532.1 X01426.1 X03067.1 24/35 DOTS entries (see all 35): DT.100826689 DT.91878430 DT.91791833 DT.452653 DT.100826691 DT.95269923 DT.40127111 DT.75122389 DT.121402840 DT.121402869 DT.104576 DT.300839 DT.97800984 DT.101961746 DT.121402689 DT.86858814 DT.91661820 DT.91761305 DT.95338993 DT.100044867 DT.121402700 DT.121402836 DT.121402845 DT.91720260 599 AceView cDNA sequences (see top 24): AA613066 AW951201 BF057731 AI433575 BF924773 BC017967 BQ056734 AA825992 CR602959 BU175417 AI474481 BG686251 AI214298 CR619088 CA309047 BI062287 BE672867 BQ065862 AA336524 W20380 AA778424 BQ066305 BF724819 BM992317 BX279593 AA293564 BF589519 BQ007765 AI656151 AA293396 AA361875 BQ061242 CA439616 BQ055498 M28202 AW610196 AW603933 BE552441 CR608651 AW796574 BC007963 AA456492 AA486532 BM711504 AA363729 AA348191 NM_002121 AA366659 CR605846 BX102440 CD368932 AA364192 AA507462 CD369806 AI299015 BM665426 R74318 AV715223 BQ707560 BQ065767 CD369157 CA946496 AI523507 BU731008 AI857536 AV697964 BQ008091 AW013960 BV208167 W35115 AA939206 AV716860 BQ642560 AI269593 AI971689 AI610843 AI268041 BI759719 BG540283 AW385137 BF664391 CD244525 BV205503 BG754817 AI817359 BV206984 BG756063 AA766763 BG686736 BG684496 BG757962 BE698425 W95190 AW291746 BF918120 BV183562 BV201008 AI921103 AW794450 BG534679 AW794436 BV205247 AI347837 BI763046 AI797881 BU146729 AW594543 AI598064 BU683073 CA436258 BQ576339 BG397627 AW473856 BV206126 BV206648 AL048489 BQ643015 BG759187 AI983916 BG685690 BM909335 BV205675 BM694593 BF974494 AI360599 BF914620 BF662850 BM479951 T29253 BV206618 AW794622 BF196486 BU940326 BQ708969 AA968428 BQ064978 BV183561 X03067 BV202832 AW206526 BQ061679 CA308804 BP360911 BV201762 AA337110 BM663160 BV183558 BV207812 BG756953 K00409 AW512211 J03041 CB958718 BQ054829 AI335756 BV205409 BV205461 CA307845 AW875252 CB998260 AI797797 BM978245 BU198728 BU680038 BF933086 CA438169 BF916522 AA411307 BQ706051 BQ061929 BI908921 BV207492 CB998417 AI811088 BF725305 AA486627 AW264925 BV207350 BV200895 M28201 BV205283 BI083997 X01426 AI367706 AJ571742 BQ004413 BV183560 AA876207 BF878107 AW404373 AA404615 M21886 BI836575 BF794166 AA906050 BI837039 BF085060 BV179977 BG530640 AI003087 BI909575 CB996260 BF796702 BF664501 AI709091 BG483896 AW404698 T61454 AV717269 BG756246 BQ711258 BG546141 BM839731 BI861131 AI640681 AW406795 AI572881 AA729059 BI752038 BM804552 BG484710 BG745984 BM685318 AI913477 AW518453 BX399274 BF095192 BI770098 AA326061 AV711647 BI908922 BI006222 BF797197 AA295043 BI825049 BX457117 BG684083 AI539795 BP375832 AA372332 W94683 BG685860 BC015000 BM464691 AI813786 AA418566 BM546745 BI761857 AA291470 BV183559 AW057770 BG570174 BG548686 BQ709515 BF339731 AA346918 CB993985 AA987254 AL702548 BI823281 BX448734 BI007655 AI814802 BG686136 AW468403 BX415638 BM822035 AA936256 CD655061 AW407090 BM705086 CA428730 AW798292 AL561604 BM465017 BE769835 BG686540 BG758432 T63385 BU602200 BF916985 AW130796 BM830820 BM821987 BF376965 BG756507 BQ447171 BP367066 BE769839 BQ711842 BG024850 AW794637 BF771893 CA308645 AI357193 AW796576 BI755645 CA427047 AW294837 BU617277 AW403600 BG686440 BE844015 BI005720 AW794685 BM975533 BE769866 AA572811 AW404300 BU150700 CD368417 R92384 CA308308 BF663876 BE769841 BQ879854 BM767205 AA325832 BI835908 BU599478 BF090865 BQ707969 AI250695 BG983374 R92385 BI833309 CA306643 BM979102 AA418635 AV709590 AL561001 AA285069 BV198094 BG757576 BG685373 BF974631 BP381683 AU076879 BI821347 AW262907 BP366874 AW518467 BF874888 BG757540 BF976201 BG542972 AI624428 CD709086 BP381386 AW264847 BF128777 AA810273 BQ016781 CB988371 BU626959 BM769312 BF974416 BM819040 BF878548 BQ082712 CA426150 BG398103 CB050863 AA496472 BG679924 AW798139 BF769977 AA319815 BX448733 BF794620 BV176723 BU615881 BF878130 AA987364 BQ056417 AW407042 AA379860 AI865413 BM830785 AW170721 BC013184 BM825684 BM708921 AW405683 AI540792 CA431539 BM694220 CA440360 BE698399 BU732783 BQ029363 AW407148 AW878602 CD703810 BX114292 BM819080 M28200 BQ227062 BF916066 BQ030339 BM546559 BM996349 X00532 CA435412 AW439061 BE829109 AW768630 AU100476 BG758859 BG535434 BF878529 BQ708843 AV703668 BG898820 BF878288 T63529 AW751230 BU621874 T90049 CA307570 AW474156 BF976318 AW405208 BI060227 AW001247 K01615 BM708731 BF664202 AI440107 M83664 AV727044 AI568321 BQ016946 AI687731 H64818 BF924287 AA652897 AW473466 AW338140 CD370389 BF795064 R74410 AW402154 BE828606 AW574925 BI836730 AW575402 CD708967 AI440156 CD690919 CA439492 BF924291 AI955841 BM856214 CA435769 AA938764 BF916061 BM768661 AW148981 BV202997 AV752942 AI281813 AW880980 AW406998 AA360684 CA407007 H64819 BE940507 AI347745 AA738206 AI886789 AV735225 AW515940 AA523103 AW794621 BG537783 BE828602 AW407753 AI250357 AI758457 BI821123 BF106359 BV203155 H93353 BE839216 AA542953 BU733090 BE043962 AW571430 BG684606 CA434721 N23695 CD723022 BG756866 BF857269 AA970796 T71631 BU602723 AI817503 AI217492 CA773329 BG719819 AI434258 BF909525 BE940662 AI431954 AW798132 BE940661 BE843830 BE836055 AL582308 CA773547 BM831007 BE843953 AA617986 AI468897 N35824 AA668826 AA579318 AI262583 AW404424 AW407180 AI300689 AW406843 AW405152 CA395734 AA935245 AI401519 AW404567 BF933635 L29173 AW885487 BU069451 T63059 BF933651 BE938563 AI887985 AI653179 AA688245 AI619643 N98977 BV184079 BG745236 AI718625 AW404651 AA074532 F32595 BE149653 AA496583 AW768603 AW794418 N66672 AV648623 CD614089 AI433576 AI469321 AI865125 AW406027 BQ718810 AW518367 CF595879 AV649112 AI500175 BE829136 AI811819 BE839188 BE836063 AV744000 BP344998 BE815889 BU790092 BE828595 AW974753 AW405090 BG230705 BQ695278 CD709577 AA617967 CD614090 AW794097 AA290957 BE839076 CD685514 AW405928 AW405382 AA361488 AJ714273 T58122 AV739225 BF917099 AA533346 T82054 AI539092 AV745026 AV743328 BM470211 AW881087 BE703064 BE829058
GeneLoc Exon Structure
|
Expression
for HLA-DPB1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HLA-DPB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCCCTTCTT
About this image
See HLA-DPB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HLA-DPB1
SOURCE GeneReport for Unigene cluster: Hs.485130
SABiosciences Custom PCR Arrays for HLA-DPB1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-DPB1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HLA-DPB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DPB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DPB1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DPB1 |
Orthologs
for HLA-DPB1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HLA-DPB1 gene from 2/5 species (see all 5) About this table
Species with no ortholog for HLA-DPB1
ENSEMBL Gene Tree for HLA-DPB1 (if available)
TreeFam Gene Tree for HLA-DPB1 (if available) |
Paralogs
for HLA-DPB1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HLA-DPB1 gene
- HLA-DRB52 HLA-DQA12 HLA-DPA12 HLA-DQB12 HLA-DRA2 HLA-DOB2 HLA-DRB12 HLA-DMA2
- HLA-DQB22 ENSG000002489932 HLA-DOA2 HLA-DMB2 HLA-DQA22
18/115 SIMAP similar genes for HLA-DPB1 using alignment to 246 protein entries: DPB1_HUMAN (see all proteins)
(see all similar genes):HLA-SB beta HLA-DPB HLA-DP DPB1 MHC DPB1 HLA-DB1
MHC-DPB1*6001 HLA-D8.2V HLA-DRB13 HLA-DBR1 HLQ-DQB1 HLA-DRB1*1327
HLA-DRB4*0102 HLA-DRB14 HLA-DRB1*0801 HLA-DRB1*11 HLA-DRB1*1605 HLA-DRBI*1303
HLA-DPB1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for HLA-DPB1
PGOHUM00000260171 PGOHUM00000260853
|
Genomic Variants
for HLA-DPB1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440Polymorphism: The following alleles of HLA-DPB1 are known: DPB1*01:01, DPB1*01:02, DPB1*02:01, DPB1*02:02, DPB1*02:03,DPB1*03:01, DPB1*03:02, DPB1*04:01, DPB1*04:02, DPB1*04:03, DPB1*05:01, DPB1*05:02, DPB1*06:01, DPB1*06:02,DPB1*08:01, DPB1*08:02, DPB1*09:01, DPB1*09:02, DPB1*10:01, DPB1*10:02, DPB1*11:01, DPB1*11:02, DPB1*13:01,DPB1*13:02, DPB1*14:01, DPB1*14:02, DPB1*15:01, DPB1*15:02, DPB1*16:01, DPB1*16:02, DPB1*17:01, DPB1*17:02,DPB1*18:01, DPB1*18:02, DPB1*19:01, DPB1*19:02, DPB1*20:01, DPB1*20:02, DPB1*21:01, DPB1*21:02, DPB1*22:01,DPB1*22:02, DPB1*23:01, DPB1*24:01, DPB1*24:02, DPB1*25:01, DPB1*25:02, DPB1*26:01, DPB1*26:02, DPB1*27:01,DPB1*28:01, DPB1*29:01, DPB1*30:01, DPB1*31:01, DPB1*32:01, DPB1*33:01, DPB1*34:01, DPB1*35:01, DPB1*36:01,DPB1*37:01, DPB1*38:01, DPB1*39:01, DPB1*40:01, DPB1*41:01, DPB1*44:01, DPB1*45:01, DPB1*46:01, DPB1*47:01,DPB1*48:01, DPB1*49:01, DPB1*50:01, DPB1*51:01, DPB1*52:01, DPB1*53:01, DPB1*54:01, DPB1*55:01, DPB1*56:01,DPB1*57:01, DPB1*58:01, DPB1*59:01, DPB1*60:01, DPB1*62:01, DPB1*63:01, DPB1*65:01, DPB1*66:01, DPB1*67:01,DPB1*68:01, DPB1*69:01, DPB1*70:01, DPB1*71:01, DPB1*72:01, DPB1*73:01, DPB1*74:01, DPB1*75:01, DPB1*76:01,DPB1*77:01, DPB1*78:01, DPB1*79:01, DPB1*80:01, DPB1*81:01, DPB1*82:01, DPB1*83:01, DPB1*84:01, DPB1*85:01,DPB1*86:01, DPB1*87:01, DPB1*88:01, DPB1*89:01, DPB1*90:01, DPB1*91:01, DPB1*92:01, DPB1*93:01, DPB1*94:01,DPB1*95:01, DPB1*96:01, DPB1*97:01, DPB1*98:01 and DPB1*99:01. The sequence shown is that of DPB1*04:01
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HLA-DPB1 (33043703 - 33054978 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for HLA-DPB1
7 CNVs: 69476 93659 81359 69477 93660 69478 59335
Human Gene Mutation Database (HGMD): HLA-DPB1
Locus Specific Mutation Databases (LSDB): HLA-DPB1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-DPB1 |
|
Disorders
/ Diseases
for HLA-DPB1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HLA-DPB1 for disorders About GeneDecksing
OMIM gene information: 142858
OMIM disorders: --
20/92  diseases for HLA-DPB1 (see all 92): About MalaCardsberyllium disease, chronic graft versus host disease hypersensitivity reaction type ii disease mixed connective tissue disease
deep vein thrombosis neuromyelitis optica connective tissue disease myasthenia gravis
cervical intraepithelial neoplasia coronary artery aneurysm type 1 diabetes mellitus wegener's granulomatosis
mycosis fungoides primary biliary cirrhosis lupus erythematosus diabetes mellitus
juvenile rheumatoid arthritis berylliosis ankylosing spondylitis toxic shock syndrome
10 Novoseek disease relationships for HLA-DPB1 gene About this table
Genetic Association Database (GAD): HLA-DPB1
Human Genome Epidemiology (HuGE) Navigator: HLA-DPB1 (168 documents)
Export disorders for HLA-DPB1 gene to outside databases
|
Publications
for HLA-DPB1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HLA-DPB1 gene, integrated from 9 sources (see all 407):
(articles sorted by number of sources associating them with HLA-DPB1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Extended HLA-DPB1 polymorphism: an RNA approach for HLA-DPB1 typing. (PubMed id 16189666)1, 2, 9 Reinders J.... Tilanus M.G.J. (2005)
- HLA-DPA1 and DPB1 polymorphism in four Pacific Islands populations determined by sequencing based typing. (PubMed id 11556979)1, 4, 9 Velickovic Z.M. and Carter J.M. (2001)
- Polymorphism of human leukocyte antigen-DRB1, -DQB1, and -DPB1 genes of Shandong Han population in China. (PubMed id 15982255)1, 4, 9 Zhou L....Xu A. (2005)
- Molecular analyses of HLA-DRB1, -DPB1, and -DQB1 in Jing ethnic minority of Southwest China. (PubMed id 12878363)1, 4, 9 Lin J.H....Xu A.L. (2003)
- [Sequencing-based typing of HLA-DPB1 and DQB1 exon 2 in patients with type 1 diabetes mellitus] (PubMed id 11592043)1, 4, 9 Zhang S....Jiang Z. (2001)
- Analysis of the role of DPB1-encoded amino acids in the genetic predisposition to type I diabetes mellitus. (PubMed id 11975985)1, 4, 9 Rayner M.L....Barnett A.H. (2002)
- Two new HLA DPB1 alleles identified by sequence-based typing: DPB1*8201 and DPB1*8301. (PubMed id 11169249)1, 2, 9 Voorter C.... van den Berg-Loonen E. (2000)
- Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease. (PubMed id 14662898)1, 4, 9 Maier L.A....Newman L.S. (2003)
- Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan. (PubMed id 12464650)1, 4, 9 Hildesheim A....Erlich H.A. (2002)
- HLA class I and class II allele and haplotype diversity in Martinicans. (PubMed id 11285127)1, 4, 9 Bera O....Semana G. (2001)
|
External Searches for HLA-DPB1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HLA-DPB1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HLA-DPB1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HLA-DPB1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HLA-DPB1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HLA-DPB1 gene:
Search GeneIP for patents involving HLA-DPB1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HLA-DPB1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HLA-DPB1 | | | OriGene Protein Over-expression Lysate for HLA-DPB1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for HLA-DPB1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DPB1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HLA-DPB1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HLA-DPB1 | | OriGene Custom Protein Services for HLA-DPB1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HLA-DPB1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-DPB1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DPB1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-DPB1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DPB1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DPB1 |
| |
 |  |  |  | |
| | | |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DPB1 |
|  |  |  | | | | Search ThermoFisher Antibodies for HLA-DPB1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DPB1 |
|
|
|
|
