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HLA-DPB1 Gene

protein-coding   GIFtS: 62
GCID: GC06P033043

Major Histocompatibility Complex, Class II, DP Beta 1


(Previous symbol: HLA-DP1B)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Major Histocompatibility Complex, Class II, DP Beta 11 2     HLA DP14-Beta Chain2
HLA-DP1B1 2 3     HLA-DP Histocompatibility Type, Beta-1 Subunit2
HLA Class II Histocompatibility Antigen, DP(W4) Beta Chain2 3     Major Histocompatibility Complex Class II Antigen Beta Chain2
MHC Class II Antigen DPB12 3     MHC Class II Antigen Beta Chain2
DPB12     MHC Class II Antigen DP Beta 1 Chain2
HLA-DP2     MHC Class II Antigen DPbeta12
HLA-DPB2     MHC Class II HLA-DP-Beta-12
Beta1 Domain MHC Class II HLA DPB2     MHC Class II HLA-DRB12
Class II HLA Beta Chain2     MHC HLA DPB12
HLA Class II Histocompatibility Antigen, DP Beta 1 Chain2     

External Ids:    HGNC: 49401   Entrez Gene: 31152   Ensembl: ENSG000002238657   OMIM: 1428585   UniProtKB: P044403   

Export aliases for HLA-DPB1 gene to outside databases

Previous GC identifers: GC06P033046 GC06P033090 GC06P033151 GC06P032786


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HLA-DPB1 Gene:
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of
an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune
system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen
presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa
and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular
domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule
both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities,
resulting in up to 4 different molecules. (provided by RefSeq, Jul 2008)

GeneCards Summary for HLA-DPB1 Gene:
HLA-DPB1 (major histocompatibility complex, class II, DP beta 1) is a protein-coding gene. Diseases associated with HLA-DPB1 include chronic berylliosis, and beryllium disease, chronic. An important paralog of this gene is HLA-DRB5.

UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440
Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
(class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the
regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
efficient peptide loading

Gene Wiki entry for HLA-DPB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NT_167244.2  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  NT_167249.2  
NC_018917.2  NT_113891.3  
Regulatory elements:
   Regulatory transcription factor binding sites in the HLA-DPB1 gene promoter:
         GR   Pbx1a   p300   FOXD3   CUTL1   MIF-1   Cdc5   STAT3   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLA-DPB1 promoter sequence
   Search Chromatin IP Primers for HLA-DPB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-DPB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

HLA-DPB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-DPB1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P033043:  view genomic region     (about GC identifiers)

Start:
33,043,703 bp from pter      End:
33,057,473 bp from pter
Size:
13,771 bases      Orientation:
plus strand

Selected alternative locations (see all 7):
Chr6+,NT_167244 4,330,504-4,344,264      Chr6+,NT_167247 4,380,558-4,394,318      Chr6+,NT_167249 4,524,207-4,537,977     
Chr6+,NT_167248 4,276,154-4,289,926      Chr6+,NT_167246 4,501,243-4,515,019      Chr6+,NT_167245 4,325,042-4,338,804     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen, DP beta 1 chain precursor  
Size: 258 amino acids; 29159 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Sequence caution: Sequence=AAQ12564.1; Type=Frameshift; Positions=39;
1 PDB 3D structure from and Proteopedia for HLA-DPB1:
3LQZ (3D)    
Secondary accessions: A0PFJ7 A5I886 A8YPB3 B5U8B4 B7VF80 B7VF87 B8ZX68 B8ZYT0 B9W5S8 B9W6F7
B9W6F9 C0MPP5 C0MPQ2 C0MPQ3 C0MPQ5 C0MPQ6 C0MPQ7 C4R9J5 C5IZL1 O00259 O19698 O19700 O19702
O19749 O46884 O77952 O98215 O98216 O98217 O98218 O98219 O98222 O98223 P01916 P04232 P13763
P79493 P79608 Q0P0L4 Q0ZFN3 Q14279 Q27S71 Q29682 Q29684 Q29698 Q29714 Q29775 Q29776 Q29778
Q29779 Q29781 Q29827 Q29828 Q29879 Q29880 Q29898 Q29977 Q2MGW3 Q30015 Q30031 Q30032 Q30033
Q30034 Q30050 Q30051 Q30052 Q30053 Q30054 Q30055 Q30174 Q4GY31 Q4JHD8 Q5ENE0 Q5ENE1 Q5ENW3
Q5EP46 Q5EP47 Q5EP49 Q5EP51 Q5EP52 Q5EP53 Q5EP56 Q5I4H8 Q5I4H9 Q5ISH4 Q5ISH5 Q5SQ73 Q5STP2
Q5YLA6 Q6IVX1 Q6LBX2 Q6LBX3 Q6LBX4 Q6LBX5 Q6LBX6 Q6LBX7 Q6PWX6 Q6TAS4 Q714U1 Q714U2 Q7YQ10
Q860Z7 Q8HWL7 Q8HWT5 Q8SNC4 Q95HC1 Q95IT7 Q95IT8 Q9BD13 Q9GIM2 Q9GIM4 Q9GIX6 Q9GJ41 Q9MY67
Q9TNT7 Q9TQE2 Q9XS11 Q9XS12

Explore the universe of human proteins at neXtProt for HLA-DPB1: NX_P04440

Explore proteomics data for HLA-DPB1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn48
  • Modification sites at PhosphoSitePlus

  • See HLA-DPB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002112.3  
    ENSEMBL proteins: 
     ENSP00000408146   ENSP00000412654   ENSP00000399832   ENSP00000439674  
    Reactome Protein details: P04440

    HLA-DPB1 Human Recombinant Protein Products:

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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    HGNC Gene Families:
    HLA: Histocompatibility complex
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    Selected InterPro protein domains (see all 7):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR000353 MHC_II_b_N
     IPR013783 Ig-like_fold
     IPR014745 MHC_II_a/b_N
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry P04440

    ProtoNet protein and cluster: P04440

    3 Blocks protein domains:
    IPB000353 Class II histocompatibility antigen
    IPB001003 MHC Class II alpha chain
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    HLA-DPB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPB1_HUMAN, P04440
    Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
    and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
    peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
    of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
    hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
    via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
    As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
    contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
    endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
    MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
    epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
    tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
    an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
    of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
    degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
    (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
    the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
    affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
    membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
    Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the
    regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
    efficient peptide loading

         Genatlas biochemistry entry for HLA-DPB1:
    HLA-DP,beta chain

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    HLA-DPB1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HLA-DPB1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HLA-DPB1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HLA-DPB1

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    2 qRT-PCR Assays for microRNAs that regulate HLA-DPB1:
    hsa-miR-767-3p hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidHLA-DPB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HLA-DPB1
    Predesigned siRNA for gene silencing in human, mouse, rat HLA-DPB1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: HLA-DPB1 (NM_002121)
    Sino Biological Human cDNA Clone for HLA-DPB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-DPB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DPB1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DPB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPB1_HUMAN, P04440: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic
    pathway until it reaches the cell membrane for antigen presentation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome5
    lysosome5
    plasma membrane5
    vacuole5
    golgi apparatus4
    extracellular2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005765lysosomal membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane IEA--
    GO:0012507ER to Golgi transport vesicle membrane TAS--

    HLA-DPB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

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    SuperPaths for HLA-DPB1 About   (see all 20)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Allograft rejection
    Allograft rejection0.86
    Asthma0.46
    Allograft Rejection0.86
    Intestinal immune network for IgA production0.41
    Type I diabetes mellitus0.69
    Viral myocarditis0.40
    Graft-versus-host disease0.65
    Antigen processing and presentation0.36
    2Translocation of ZAP-70 to Immunological synapse
    Translocation of ZAP-70 to Immunological synapse0.83
    PD-1 signaling0.72
    Phosphorylation of CD3 and TCR zeta chains0.83
    Generation of second messenger molecules0.62
    3Immune response Antigen presentation by MHC class II
    Immune response Antigen presentation by MHC class II0.46
    Immune response IL 22 signaling pathway0.31
    G protein signaling N RAS regulation pathway0.46
    4Interferon Signaling
    Interferon Signaling0.59
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.59
    5Immune response NFAT in immune response
    Immune response NFAT in immune response0.55
    Immune response T cell receptor signaling pathway0.50
    Immune response ICOS pathway in T helper cell0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for HLA-DPB1 (see all 6)
        Immune response Antigen presentation by MHC class II
    Immune response ICOS pathway in T-helper cell
    Immune response T cell receptor signaling pathway
    Immune response IL-22 signaling pathway
    G-protein signaling N-RAS regulation pathway

    1 BioSystems Pathway for HLA-DPB1
        Allograft Rejection

    1 Sino Biological Pathway for HLA-DPB1
        NF-kB (NFkB) Pathway

    Selected Reactome Pathways for HLA-DPB1 (see all 7)
        Translocation of ZAP-70 to Immunological synapse
    Interferon gamma signaling
    Downstream TCR signaling
    PD-1 signaling
    MHC class II antigen presentation


    Selected Kegg Pathways  (Kegg details for HLA-DPB1) (see all 21):
        Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Intestinal immune network for IgA production
    Type I diabetes mellitus


    HLA-DPB1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HLA-DPB1
    Interactions:

        GeneGlobe Interaction Network for HLA-DPB1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for HLA-DPB1 (P044402, 3 ENSP000004081464) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ROBO2Q9HCK42, 3MINT-8258142 I2D: score=2 
    RTN4Q9NQC32, 3MINT-8258153 I2D: score=2 
    HLA-DPA1P200363, ENSP000003935664I2D: score=1 STRING: ENSP00000393566
    ENSG00000168384P200363I2D: score=1 
    ENSG00000206291P200363I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002504antigen processing and presentation of peptide or polysaccharide antigen via MHC class II ----
    GO:0006955immune response ----
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0019882antigen processing and presentation ----
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    HLA-DPB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HLA-DPB1 (DPB1)

    4 Novoseek inferred chemical compound relationships for HLA-DPB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpa 1 96.1 37 11556979 (4), 1348744 (3), 7710763 (2), 8225437 (2) (see all 15)
    beryllium 66.1 7 10415070 (2), 11551429 (2), 10860658 (1), 14662898 (1)
    oligonucleotide 30.5 6 8436419 (1), 8863870 (1), 10566595 (1), 1971269 (1) (see all 5)
    glutamate 0 1 11551429 (1)



    HLA-DPB1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for HLA-DPB1 gene: 
    NM_002121.5  

    Unigene Cluster for HLA-DPB1:

    Major histocompatibility complex, class II, DP beta 1
    Hs.485130  [show with all ESTs]
    Unigene Representative Sequence: NM_002121
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418931(uc003ocu.2 uc011dqo.2) ENST00000469120 ENST00000471184
    ENST00000488575 ENST00000498038 ENST00000428835 ENST00000416804(uc011dqq.1)
    ENST00000478189 ENST00000535465(uc011dqn.2)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    2 qRT-PCR Assays for microRNAs that regulate HLA-DPB1:
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    SwitchGear 3'UTR luciferase reporter plasmidHLA-DPB1 3' UTR sequence
    Inhib. RNA
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    OriGene clones in human, mouse for HLA-DPB1 (see all 8)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLA-DPB1 (NM_002121)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-DPB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DPB1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HLA-DPB1
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-DPB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HLA-DPB1
      QuantiTect SYBR Green Assays in human, mouse, rat HLA-DPB1
      QuantiFast Probe-based Assays in human, mouse, rat HLA-DPB1

    Additional mRNA sequence: 

    AB208978.1 AK291986.1 AK301322.1 AK303153.1 AK313305.1 AY656678.1 AY656679.1 AY656680.1 
    AY804132.1 AY804133.1 AY804134.1 AY804135.1 AY804136.1 AY804137.1 AY804138.1 AY804139.1 
    AY804140.1 AY804141.1 AY804142.1 AY804143.1 AY831401.1 AY831402.1 AY831403.1 AY831404.1 
    BC007963.2 BC013184.1 BC015000.1 BT019780.1 DQ284441.1 FR775797.1 FR775798.1 GQ891549.1 
    HE603611.1 HE603612.1 HE614584.1 HE614585.1 HE614586.1 HE614587.1 HE614588.1 HE614589.1 
    HE614590.1 HE614591.1 J03041.1 K00409.1 K01615.1 L29173.1 M21886.1 M28200.1 
    M28201.1 M28202.1 M57466.1 M83664.1 S66883.1 S79786.1 X00532.1 X01426.1 
    X03067.1 

    Selected DOTS entries (see all 35):

    DT.100826689  DT.91878430  DT.91791833  DT.452653  DT.100826691  DT.95269923  DT.40127111  DT.75122389 
    DT.121402840  DT.121402869  DT.104576  DT.300839  DT.97800984  DT.101961746  DT.121402689  DT.86858814 
    DT.91661820  DT.91761305  DT.95338993  DT.100044867  DT.121402700  DT.121402836  DT.121402845  DT.91720260 

    Selected AceView cDNA sequences (see all 599):

    CA439616 AA778424 W20380 AA293564 AA486532 BQ065862 BC017967 AA361875 
    BF724819 BQ066305 BQ007765 CA309047 AA507462 BM665426 BX279593 AI656151 
    BI062287 AA348191 NM_002121 BG686251 BU175417 AI214298 AW610196 CR619088 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HLA-DPB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCCTTCTT
    HLA-DPB1 Expression
    About this image


    HLA-DPB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
     
     Tonsil (Hematopoietic System)
     
     Spleen (Hematopoietic System)
    HLA-DPB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HLA-DPB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485130
        Custom PCR Arrays for HLA-DPB1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HLA-DPB1
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-DPB1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HLA-DPB1
    QuantiTect SYBR Green Assays in human, mouse, rat HLA-DPB1
    QuantiFast Probe-based Assays in human, mouse, rat HLA-DPB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DPB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-DPB1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia HLA-DPB16
    major histocompatibility complex, class II, DP bet...
    50(a)
    1 ↔ 1
    12(2604546-2607784)
    chicken
    (Gallus gallus)
    Aves BLB31 Major histocompatibility complex class II beta chain more 65.72(n)
    54.03(a)
      425256  XM_423039.4  XP_423039.4 


    ENSEMBL Gene Tree for HLA-DPB1 (if available)
    TreeFam Gene Tree for HLA-DPB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HLA-DPB1 gene
    HLA-DRB52  HLA-DQA12  HLA-DPA12  HLA-DQB12  HLA-DRA2  HLA-DRB12  HLA-DOB2  HLA-DMA2  
    HLA-DQB22  HLA-DOA2  ENSG000002489932  HLA-DMB2  HLA-DQA22  
    Selected SIMAP similar genes for HLA-DPB1 using alignment to 265 protein entries:     DPB1_HUMAN (see all proteins) (see all similar genes):
    HLA-SB beta    HLA-DPB    HLA-DP    DPB1    MHC DPB1    HLA-DB1
    MHC-DPB1*6001    HLA-D8.2V    HLA-DRB13    HLA-DRB1*1327    HLA-DRB4*0102    HLA-DRB14
    HLA-DRB1*0801    HLQ-DQB1    HLA-DRB1*11    HLA-DRB1*1125    HLA-DRBI*1303    HLA-DRB1*1605

    HLA-DPB1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for HLA-DPB1
    PGOHUM00000260171 PGOHUM00000260853


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    DPB1_HUMAN, P04440: The following alleles of HLA-DPB1 are known: DPB1*01:01, DPB1*01:02, DPB1*02:01, DPB1*02:02,
    DPB1*02:03, DPB1*03:01, DPB1*03:02, DPB1*04:01, DPB1*04:02, DPB1*04:03, DPB1*05:01, DPB1*05:02, DPB1*06:01,
    DPB1*06:02, DPB1*08:01, DPB1*08:02, DPB1*09:01, DPB1*09:02, DPB1*10:01, DPB1*10:02, DPB1*11:01, DPB1*11:02,
    DPB1*13:01, DPB1*13:02, DPB1*14:01, DPB1*14:02, DPB1*15:01, DPB1*15:02, DPB1*16:01, DPB1*16:02, DPB1*17:01,
    DPB1*17:02, DPB1*18:01, DPB1*18:02, DPB1*19:01, DPB1*19:02, DPB1*20:01, DPB1*20:02, DPB1*21:01, DPB1*21:02,
    DPB1*22:01, DPB1*22:02, DPB1*23:01, DPB1*24:01, DPB1*24:02, DPB1*25:01, DPB1*25:02, DPB1*26:01, DPB1*26:02,
    DPB1*27:01, DPB1*28:01, DPB1*29:01, DPB1*30:01, DPB1*31:01, DPB1*32:01, DPB1*33:01, DPB1*34:01, DPB1*35:01,
    DPB1*36:01, DPB1*37:01, DPB1*38:01, DPB1*39:01, DPB1*40:01, DPB1*41:01, DPB1*44:01, DPB1*45:01, DPB1*46:01,
    DPB1*47:01, DPB1*48:01, DPB1*49:01, DPB1*50:01, DPB1*51:01, DPB1*52:01, DPB1*53:01, DPB1*54:01, DPB1*55:01,
    DPB1*56:01, DPB1*57:01, DPB1*58:01, DPB1*59:01, DPB1*60:01, DPB1*62:01, DPB1*63:01, DPB1*65:01, DPB1*66:01,
    DPB1*67:01, DPB1*68:01, DPB1*69:01, DPB1*70:01, DPB1*71:01, DPB1*72:01, DPB1*73:01, DPB1*74:01, DPB1*75:01,
    DPB1*76:01, DPB1*77:01, DPB1*78:01, DPB1*79:01, DPB1*80:01, DPB1*81:01, DPB1*82:01, DPB1*83:01, DPB1*84:01,
    DPB1*85:01, DPB1*86:01, DPB1*87:01, DPB1*88:01, DPB1*89:01, DPB1*90:01, DPB1*91:01, DPB1*92:01, DPB1*93:01,
    DPB1*94:01, DPB1*95:01, DPB1*96:01, DPB1*97:01, DPB1*98:01 and DPB1*99:01. The sequence shown is that of
    DPB1*04:01


    Selected SNPs for HLA-DPB1 (see all 493)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10421401,2,,4
    C,Fother132964610(+) AGGAGA/C/G/
            
    AGCGG
    2 K E mis110MN NA WA CSA EA EU 6274
    rs1415302331,2
    C--33048688(+) GGGCG-/AGGCCC 2 G EA fra10--------
    rs3757949251,2
    C--33050526(+) ATGTC-/TCACCC 1 -- int10--------
    rs1907550351,2
    --33050561(+) GTTTTC/TTGGGC 1 -- int10--------
    rs31289601,2
    C,F,H--33050654(+) TATCAA/GGCCTT 1 -- int113Minor allele frequency- G:0.47NS EA WA NA CSA 781
    rs30976731,2
    C,F,H--33050671(+) AGCGCA/CCCCTG 1 -- int110Minor allele frequency- C:0.42NS WA NA CSA EA 481
    rs30976741,2
    C,F,H--33050683(+) AGGTCA/C/GCTGAT 1 -- int113NS EA WA NA CSA 749
    rs31289611,2
    C,F,O,H--33050742(+) CTCTCA/GTGGAA 1 -- int113Minor allele frequency- G:0.47NS EA WA NA CSA 771
    rs1150218821,2
    F--33050796(+) TTCATG/AGTTCC 1 -- int11Minor allele frequency- A:0.01NA 120
    rs92773921,2
    C,F--33050829(+) TTGTAC/GGTAAT 1 -- int112Minor allele frequency- G:0.49NA WA CSA EA 505

    HapMap Linkage Disequilibrium report for HLA-DPB1 (33043703 - 33057473 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HLA-DPB1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731879CNV Deletion23290073
    dgv1047e201CNV Deletion23290073
    esv22467CNV Loss19812545
    dgv6828n71CNV Loss21882294
    dgv1042n67CNV Loss20364138
    nsv823656CNV Loss20364138
    nsv516221CNV Loss19592680
    dgv1041n67CNV Loss20364138
    nsv885759CNV Loss21882294
    nsv823645CNV Loss20364138

    Human Gene Mutation Database (HGMD): HLA-DPB1
    Locus Specific Mutation Databases (LSDB): HLA-DPB1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HLA-DPB1
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-DPB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142858    OMIM disorders: --

    Selected diseases for HLA-DPB1 (see all 97):    
    About MalaCards
    chronic berylliosis    beryllium disease, chronic    berylliosis    wegener's granulomatosis
    rubella    myelitis    coronary artery aneurysm    chronic thromboembolic pulmonary hypertension
    autoimmune pancreatitis    neuromyelitis optica    mumps    takayasu's arteritis
    juvenile rheumatoid arthritis    myasthenia gravis    silicosis    mixed connective tissue disease
    graft versus host disease    cutaneous leishmaniasis    toxic shock syndrome    connective tissue disease


    HLA-DPB1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10 Novoseek inferred disease relationships for HLA-DPB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beryllium disease chronic 77.6 3 10415070 (1), 10860658 (1), 14662898 (1)
    genetic susceptibility 52.7 6 11975985 (1), 17060025 (1), 1980918 (1), 7843712 (1) (see all 5)
    arthritis juvenile rheumatoid 40.5 1 8436419 (1)
    diabetes mellitus insulin-dependent 32.3 3 11592043 (3)
    myasthenia gravis 18.1 2 8357200 (1), 7749041 (1)
    graft-versus-host disease 13.6 1 8932283 (1)
    systemic disease 9.97 1 10616003 (1)
    lupus erythematosus systemic 7.62 1 8456439 (1)
    multiple sclerosis 3.56 3 1918327 (2), 1926126 (1)
    rheumatoid arthritis 0 2 1429034 (1), 1822107 (1)

    Genetic Association Database (GAD): HLA-DPB1
    Human Genome Epidemiology (HuGE) Navigator: HLA-DPB1 (168 documents)

    Export disorders for HLA-DPB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HLA-DPB1 gene, integrated from 10 sources (see all 421) (see top 10):
    (articles sorted by number of sources associating them with HLA-DPB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Extended HLA-DPB1 polymorphism: an RNA approach for HLA-DPB1 typing. (PubMed id 16189666)1, 2, 9 Reinders J.... Tilanus M.G.J. (Immunogenetics 2005)
    2. HLA-DPA1 and DPB1 polymorphism in four Pacific Islands populations determined by sequencing based typing. (PubMed id 11556979)1, 4, 9 Velickovic Z.M. and Carter J.M. (Tissue Antigens 2001)
    3. Polymorphism of human leukocyte antigen-DRB1, -DQB1, and -DPB1 genes of Shandong Han population in China. (PubMed id 15982255)1, 4, 9 Zhou L....Xu A. (Tissue Antigens 2005)
    4. Molecular analyses of HLA-DRB1, -DPB1, and -DQB1 in Jing ethnic minority of Southwest China. (PubMed id 12878363)1, 4, 9 Lin J.H....Xu A.L. (Hum. Immunol. 2003)
    5. Polymorphism of HLA-DRB1, -DQB1 and -DPB1 genes in Bai ethnic group in southwestern China. (PubMed id 18778327)1, 4, 9 Hu W....Xiao C. (Tissue Antigens 2008)
    6. [Sequencing-based typing of HLA-DPB1 and DQB1 exon 2 in patients with type 1 diabetes mellitus]. (PubMed id 11592043)1, 4, 9 Zhang S....Jiang Z. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2001)
    7. Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controls. (PubMed id 18486765)1, 4, 9 Noble J.A....Erlich H.A. (Hum. Immunol. 2008)
    8. Association of HLA class II DRB1, DPA1 and DPB1 polymorphism with genetic susceptibility to idiopathic dilated cardiomyopathy in Chinese Han nationality. (PubMed id 17060025)1, 4, 9 Liu W....Gan R.T. (Autoimmunity 2006)
    9. Analysis of the role of DPB1-encoded amino acids in the genetic predisposition to type I diabetes mellitus. (PubMed id 11975985)1, 4, 9 Rayner M.L....Barnett A.H. (Hum. Immunol. 2002)
    10. Two new HLA DPB1 alleles identified by sequence-based typing: DPB1*8201 and DPB1*8301. (PubMed id 11169249)1, 2, 9 Voorter C.... van den Berg-Loonen E. (Tissue Antigens 2000)
    11. Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease. (PubMed id 14662898)1, 4, 9 Maier L.A....Newman L.S. (J. Immunol. 2003)
    12. Effect of human leukocyte antigen homozygosity on rubella vaccine-induced humoral and cell-mediated immune responses. (PubMed id 19896518)1, 4, 9 Kennedy R.B....Poland G.A. (Hum. Immunol. 2010)
    13. Association of the HLA-DPB1*0501 allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders. (PubMed id 19140826)1, 4, 9 Matsushita T....Kira J. (Tissue Antigens 2009)
    14. HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis. (PubMed id 19165231)1, 4, 9 Kominami S....Kimura A. (J. Hum. Genet. 2009)
    15. Analysis of maternal-offspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes. (PubMed id 19143818)1, 4, 9 Bronson P.G....Barcellos L.F. (amp 2009)
    16. Association of TNF-alpha genetic polymorphism with HLA DPB1*0301. (PubMed id 17014432)1, 4, 9 Kim S.H....Park H.S. (Clin. Exp. Allergy 2006)
    17. Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan. (PubMed id 12464650)1, 4, 9 Hildesheim A....Erlich H.A. (J. Natl. Cancer Inst. 2002)
    18. HLA class I and class II allele and haplotype diversity in Martinicans. (PubMed id 11285127)1, 4, 9 Bera O....Semana G. (Tissue Antigens 2001)
    19. Genetic susceptibility to breast cancer: HLA DQB*03032 and HLA DRB1*11 may represent protective alleles. (PubMed id 11027344)1, 4, 9 Chaudhuri S....Pillai S. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    20. A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region. (PubMed id 21764829)1, 4 Png E....Seielstad M. (Hum. Mol. Genet. 2011)
    21. Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population. (PubMed id 21274863)1, 4 Guo X....O'Brien S.J. (Hepatology 2011)
    22. Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. (PubMed id 21779181)1, 4 Gorlova O....Martin J. (PLoS Genet. 2011)
    23. Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. (PubMed id 21814517)1, 4 Noguchi E....Matsumoto K. (PLoS Genet. 2011)
    24. A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. (PubMed id 21750111)1, 4 Mbarek H....Matsuda K. (Hum. Mol. Genet. 2011)
    25. HLA and CTLA4 polymorphisms may confer a synergistic risk in the susceptibility to Graves' disease. (PubMed id 20300120)1, 4 Takahashi M. and Kimura A. (J. Hum. Genet. 2010)
    26. A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis. (PubMed id 21049023)1, 4 Field J....Stankovich J. (PLoS ONE 2010)
    27. Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects. (PubMed id 20191588)1, 4 Hollenbach J.A....Glass D.N. (Arthritis Rheum. 2010)
    28. HLA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: analysis of the type 1 diabetes genetics consortium families. (PubMed id 20424227)1, 4 Varney M.D....Erlich H. (Diabetes 2010)
    29. Association between HLA-B*4001 and lipodystrophy among HIV-infected patients from Thailand who received a stavudine-containing antiretroviral regimen. (PubMed id 20073992)1, 4 Wangsomboonsiri W....Sungkanuparph S. (Clin. Infect. Dis. 2010)
    30. HLA genotyping in the international Type 1 Diabetes Genetics Consortium. (PubMed id 20595243)1, 4 Mychaleckyj J.C....Erlich H.A. (Clin Trials 2010)
    31. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    32. Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls. (PubMed id 19596691)1, 4 Arnett F.C....Reveille J.D. (Ann. Rheum. Dis. 2010)
    33. Refining the association of MHC with multiple sclerosis in African Americans. (PubMed id 20466734)1, 4 McElroy J.P....Gourraud P.A. (Hum. Mol. Genet. 2010)
    34. Replication of rubella vaccine population genetic studies: validation of HLA genotype and humoral response associations. (PubMed id 19761839)1, 4 Ovsyannikova I.G....Poland G.A. (Vaccine 2009)
    35. HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients. (PubMed id 19104471)1, 4 Chantarangsu S....Nakamura Y. (Pharmacogenet. Genomics 2009)
    36. HLA mismatch combinations associated with decreased risk of relapse: implications for the molecular mechanism. (PubMed id 18997170)1, 4 Kawase T....Morishima Y. (Blood 2009)
    37. HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms. (PubMed id 19180512)1, 4 Lin Y.J....Tsai F.J. (Arthritis Rheum. 2009)
    38. Strong association of the HLA-DP6 supertype with childhood leukaemia is due to a single allele, DPB1*0601. (PubMed id 19148140)1, 4 Taylor G.M....Birch J.M. (Leukemia 2009)
    39. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
    40. Association of susceptibility to multiple sclerosis in Southern Han Chinese with HLA-DRB1, -DPB1 alleles and DRB1-DPB1 haplotypes: distinct from other populations. (PubMed id 19965521)1, 4 Wu X.M....Gong L.Y. (Mult. Scler. 2009)
    41. Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. (PubMed id 19143813)1, 4 Howson J.M....Todd J.A. (amp 2009)
    42. HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: a genome-wide association study in Koreans with replication in North Americans. (PubMed id 19950302)1, 4 Zhou X....Lee E.B. (Arthritis Rheum. 2009)
    43. TNF and LTA gene, allele, and extended HLA haplotype associations with severe dengue virus infection in ethnic Thais. (PubMed id 19392621)1, 4 Vejbaesya S....Stephens H.A. (J. Infect. Dis. 2009)
    44. HLA-A disparities illustrate challenges for ranking the impact of HLA mismatches on bone marrow transplant outcomes in the United States. (PubMed id 19589487)1, 4 Baxter-Lowe L.A....Hurley C.K. (Biol. Blood Marrow Transplant. 2009)
    45. HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine. (PubMed id 19200828)1, 4 Ovsyannikova I.G....Poland G.A. (Vaccine 2009)
    46. Is neuromyelitis optica associated with human leukocyte antigen? (PubMed id 19299434)1, 4 ZAcphir H....de Seze J. (Mult. Scler. 2009)
    47. The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype is a risk factor for toluene diisocyanate-induced occupational asthma. (PubMed id 19439981)1, 4 Choi J.H....Park H.S. (Int. Arch. Allergy Immunol. 2009)
    48. A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. (PubMed id 19349983)1, 4 Kamatani Y....Matsuda K. (Nat. Genet. 2009)
    49. Conditional analyses on the T1DGC MHC dataset: novel associations with type 1 diabetes around HLA-G and confirmation of HLA-B. (PubMed id 18830248)1, 4 Eike M.C....Lie B.A. (Genes Immun. 2009)
    50. Clinical and immunogenetic prognostic factors for radiographic severity in ankylosing spondylitis. (PubMed id 19565552)1, 4 Ward M.M....Weisman M.H. (Arthritis Rheum. 2009)
    51. Inhibitor-Immunology-Study. Different HLA-types seem to be involved in the inhibitor development in haemophilia A. (PubMed id 18958335)1, 4 Wieland I....Sykora K.W. (Hamostaseologie 2008)
    52. Impact of HLA-DPB1 allelic and single amino acid mismatches on HSCT. (PubMed id 18544086)1, 4 Ludajic K....Greinix H.T. (Br. J. Haematol. 2008)
    53. HLA-DPbeta chain may confer the susceptibility to hepatitis C virus-associated hypertrophic cardiomyopathy. (PubMed id 18186799)1, 4 Shichi D....Kimura A. (Int. J. Immunogenet. 2008)
    54. The clinical implications of HLA mismatches in unrelated donor haematopoietic cell transplantation. (PubMed id 18976440)1, 4 Shaw B.E. (Int. J. Immunogenet. 2008)
    55. Anti-cofactor autoantibodies in systemic lupus erythematosus: prevalence, clinical and HLA class II associations. (PubMed id 18569076)1, 4 Sebastiani G.D....Galeazzi M. (Immunol. Invest. 2008)
    56. HLA-DQB1 and -DPB1 allele profile in HIV infected patients with and without pulmonary tuberculosis of south India. (PubMed id 18652916)1, 4 Selvaraj P....Narayanan P.R. (Infect. Genet. Evol. 2008)
    57. Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus. (PubMed id 18309376)1, 4 Lee H.S....Gregersen P.K. (Mol. Med. 2008)
    58. HLA-associated susceptibility to childhood B-cell precursor ALL: definition and role of HLA-DPB1 supertypes. (PubMed id 18334973)1, 4 Taylor G.M....Greaves M.F. (Br. J. Cancer 2008)
    59. Some but not all of HLA-II alleles are associated with cervical cancer in Chinese women. (PubMed id 19027490)1, 4 Liang J....Lin Z. (Cancer Genet. Cytogenet. 2008)
    60. The Wegener's granulomatosis quantitative trait locus on chromosome 6p21.3 as characterised by tagSNP genotyping. (PubMed id 17967832)1, 4 Heckmann M....Wieczorek S. (Ann. Rheum. Dis. 2008)
    61. Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis. (PubMed id 18952831)1, 4 Matsuoka T....Kira J. (Mult. Scler. 2008)
    62. HLA-A, B, Cw, DRB1, DQB1 and DPB1 alleles and haplotypes in the genetically homogenous Irish population. (PubMed id 18976432)1, 4 Dunne C....Lawlor E. (Int. J. Immunogenet. 2008)
    63. High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism. (PubMed id 17554059)1, 4 Kawase T....Sasazuki T. (Blood 2007)
    64. Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger disease. (PubMed id 17653770)1, 4 Chen Z....Kimura A. (Hum. Genet. 2007)
    65. The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation. (PubMed id 17726164)1, 4 Shaw B.E....Petersdorf E.W. (Blood 2007)
    66. [Association of HLA-DRB1 and -DPB1 allele polymorphism with multiple sclerosis in Chinese Han population from Southern areas]. (PubMed id 18167262)1, 4 Wu X.M....Xie X.F. (Zhonghua Yi Xue Za Zhi 2007)
    67. HLA class II polymorphisms associated with the physiologic characteristics defined by Traditional Chinese Medicine: linking modern genetics with an ancient medicine. (PubMed id 17388766)1, 4 Chen S....Xu A. (J Altern Complement Med 2007)
    68. HPV16 E6 variants and HLA class II polymorphism among Chinese women with cervical cancer. (PubMed id 17311339)1, 4 Wu Y....Xu A. (J. Med. Virol. 2007)
    69. Effects of HLA allele and killer immunoglobulin-like receptor ligand matching on clinical outcome in leukemia patients undergoing transplantation with T-cell-replete marrow from an unrelated donor. (PubMed id 17317585)1, 4 Morishima Y....Kodera Y. (Biol. Blood Marrow Transplant. 2007)
    70. Human leukocyte antigen class II alleles and risk of cervical cancer in China. (PubMed id 17349874)1, 4 Wu Y....Xu A. (Hum. Immunol. 2007)
    71. HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY population. (PubMed id 17513705)1, 4 Baschal E.E....Eisenbarth G.S. (Diabetes 2007)
    72. HLA class II amino acid epitopes as susceptibility markers of sarcoidosis. (PubMed id 17559577)1, 4 Voorter C.E....van den Berg-Loonen E.M. (Tissue Antigens 2007)
    73. Association of immune responses to mycobacterium tuberculosis peptide antigens with host genetic factors. (PubMed id 17153701)1, 4 Saad A.H....Zakaria Z. (J Egypt Soc Parasitol 2006)
    74. Interaction of loci within the HLA region influences multiple sclerosis course in the Sardinian population. (PubMed id 16096810)1, 4 Marrosu M.G....Contu P. (J. Neurol. 2006)
    75. HLA DRB1*15-DPB1*05 haplotype: a susceptible gene marker for isocyanate-induced occupational asthma? (PubMed id 16792590)1, 4 Kim S.H....Park H.S. (Allergy 2006)
    76. Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine. (PubMed id 16453260)1, 4 Ovsyannikova I.G....Poland G.A. (J. Infect. Dis. 2006)
    77. Association of HLA-DPB1 alleles with type I diabetes mellitus in Slovak population. (PubMed id 16796127)1, 4 Stuchlikova M....Buc M. (Bratisl Lek Listy 2006)
    78. HLA-DPB1*0202 is associated with a predictor of good prognosis of Graves' disease in the Japanese. (PubMed id 16698425)1, 4 Takahashi M....Kimura A. (Hum. Immunol. 2006)
    79. HLA-DPB1 matching status has significant implications for recipients of unrelated donor stem cell transplants. (PubMed id 16234356)1, 4 Shaw B.E....Madrigal J.A. (Blood 2006)
    80. Class II HLA allele polymorphism: DRB1, DQB1 and DPB1 alleles and haplotypes in the New Zealand Maori population. (PubMed id 17026464)1, 4 Tracey M.C. and Carter J.M. (Tissue Antigens 2006)
    81. HLA-dPB1*0501 is not uniquely associated with opticospinal multiple sclerosis in Japanese patients. Important role of DPB1*0301. (PubMed id 16459716)1, 4 Fukazawa T....Sasaki H. (Mult. Scler. 2006)
    82. Identification of a novel HLA-DPB1 allele, DPB1*1702. (PubMed id 16866899)1, 2 Li M.... Yu X. (Tissue Antigens 2006)
    83. The prevalence of human leukocyte antigen (HLA) DR/DQ/DP alleles in Kuwaiti children with oligoarticular juvenile idiopathic arthritis. (PubMed id 15703957)1, 4 Alsaeid K....Ayoub E.M. (Rheumatol. Int. 2006)
    84. High-resolution molecular characterization of the HLA class I and class II in the Tarahumara Amerindian population. (PubMed id 16866883)1, 4 GarcA-a-Ortiz J.E....ArgA1ello J.R. (Tissue Antigens 2006)
    85. Alteration of the influences of HLA classes I and II alleles on the perinatal hepatitis B virus infection after immunoprophylaxis in Korean children. (PubMed id 16890179)1, 4 Kim J.H....Kim T.G. (Hepatol. Res. 2006)
    86. HLA class II alleles and measles virus-specific cytokine immune response following two doses of measles vaccine. (PubMed id 15712014)1, 4 Ovsyannikova I.G....Poland G.A. (Immunogenetics 2005)
    87. The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria. (PubMed id 15784113)1, 4 Kim S.H....Park H.S. (Clin. Exp. Allergy 2005)
    88. Association of clinical features with HLA in chronic pulmonary thromboembolism. (PubMed id 15640334)1, 4 Tanabe N....Kuriyama T. (Eur. Respir. J. 2005)
    89. The DR4-DQ8 haplotype and a specific T cell receptor Vbeta T cell subset are associated with absence of allergy to Can f 1. (PubMed id 15969672)1, 4 Kinnunen T....Virtanen T. (Clin. Exp. Allergy 2005)
    90. Human leukocyte antigen class II alleles and rubella-specific humoral and cell-mediated immunity following measles-mumps-rubella-II vaccination. (PubMed id 15655774)1, 4 Ovsyannikova I.G....Poland G.A. (J. Infect. Dis. 2005)
    91. DNA-sequence determination of exon 2 of a novel HLA-DPB1 allele, HLA- DPB1*0403. (PubMed id 16147881)1, 2 Weston A.... Frye B.L. (DNA Seq. 2005)
    92. Identification of a new allele in a Sicilian individual: HLA- DPB1*0302. (PubMed id 15982263)1, 2 Sheldon M.H.... Sortino G. (Tissue Antigens 2005)
    93. HLA alleles and risk of cervical intraepithelial neoplasia among southwestern American Indian women. (PubMed id 16386646)1, 4 Schiff M.A....Becker T.M. (Hum. Immunol. 2005)
    94. HLA-DPB1 mismatch and acute graft-versus host disease in HLA-identical sibling donors. (PubMed id 17977207)1, 4 Mosaad Y.M. and Kamel H. (Egypt J Immunol 2005)
    95. Function associated transforming growth factor-beta gene polymorphism in chronic beryllium disease. (PubMed id 15750822)1, 4 Gaede K.I....MA1ller-Quernheim J. (J. Mol. Med. 2005)
    96. Anti-caspase-8 autoantibody response in silicosis patients is associated with HLA-DRB1, DQB1 and DPB1 alleles. (PubMed id 15703453)1, 4 Ueki A....Kusaka M. (J Occup Health 2005)
    97. HLA-DP polymorphism in Venezuelan Amerindians. (PubMed id 15603877)1, 4 Gendzekhadze K....Layrisse Z. (Hum. Immunol. 2004)
    98. Identification of a novel HLA-DPB1 allele--DPB1*0102. (PubMed id 15361132)1, 2 Lv F.... Xu A. (Tissue Antigens 2004)
    99. DPB1 alleles are associated with type 1 diabetes susceptibility in multiple ethnic groups. (PubMed id 15277401)1, 4 Cruz T.D....Noble J.A. (Diabetes 2004)
    100. Role of HLA class II alleles in susceptibility to and protection from localized cutaneous leishmaniasis. (PubMed id 15041165)1, 4 Olivo-DA-az A....Gorodezky C. (Hum. Immunol. 2004)
    101. Genetic polymorphism and linkage disequilibrium of the HLA-DP region in Basques from Navarre (Spain). (PubMed id 15304007)1, 4 PAcrez-Miranda A.M....PeA+a J.A. (Tissue Antigens 2004)
    102. A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation. (PubMed id 14576061)1, 4 Zino E....Fleischhauer K. (Blood 2004)
    103. The association between HLA-DPB1Glu69 and chronic beryllium disease and beryllium sensitization. (PubMed id 15273960)1, 4 McCanlies E.C....Weston A. (Am. J. Ind. Med. 2004)
    104. HLA class-I and HLA class-II phenotypic, gene and haplotypic frequencies in Tunisians by using molecular typing data. (PubMed id 15361135)1, 4 Ayed K....Gebuhrer L. (Tissue Antigens 2004)
    105. Human leukocyte antigen class II associations with systemic sclerosis in South Africans. (PubMed id 15104683)1, 4 Tikly M....Welsh K. (Tissue Antigens 2004)
    106. Strong linkage disequilibrium between HLA-B*3913 and DRB1*0807 in Brazilians. (PubMed id 15194283)1, 4 Moraes M.E....Moraes J.R. (Transplant. Proc. 2004)
    107. HLA-DRB1, TAP2/TAP1, and HLA-DPB1 haplotypes in Finnish juvenile idiopathic arthritis: more complexity within the MHC. (PubMed id 15343265)1, 4 Runstadler J.A....Seldin M.F. (Genes Immun. 2004)
    108. [Association of HLA-DPB1 alleles with chronic myelogenous leukemia in southern Chinese Hans]. (PubMed id 12844410)1, 4 Tian H....Xu A.L. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2003)
    109. HLA-DRB1, DQB1 and DPB1 polymorphism in the Naxi ethnic group of South-western China. (PubMed id 12694588)1, 4 Fu Y....Xu A. (Tissue Antigens 2003)
    110. [Association study on HLA-DP and -DQ allelic polymorphisms and nasopharyngeal carcinoma in the Han nationality in Hunan province]. (PubMed id 12778461)1, 4 Zhou J.F....Yu P. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2003)
    111. High resolution sequence-based DPB1 typing identified two novel DPB1 alleles, DPB1*9401 and DPB1*9501, from a Kenyan population. (PubMed id 12890000)1, 2 Luo M.... Plummer F.A. (Tissue Antigens 2003)
    112. The degree of matching at HLA-DPB1 predicts for acute graft-versus-host disease and disease relapse following haematopoietic stem cell transplantation. (PubMed id 12774051)1, 4 Shaw B.E....Madrigal J.A. (Bone Marrow Transplant. 2003)
    113. Associations between patients with endometriosis and HLA class II; the analysis of HLA-DQB1 and HLA-DPB1 genotypes. (PubMed id 12721173)1, 4 Ishii K....Tanaka K. (Hum. Reprod. 2003)
    114. Roles of HLA-B, HLA-C and HLA-DPA1 incompatibilities in the outcome of unrelated stem-cell transplantation. (PubMed id 12956878)1, 4 Schaffer M....Olerup O. (Tissue Antigens 2003)
    115. Identification of a novel DPB1 allele, DPB1*9301, by sequence-based typing in a Lahu ethnic minority of China. (PubMed id 12694578)1, 2 Liu Z.-H.... Xu A. (Tissue Antigens 2003)
    116. HLA-DPB1 alleles association of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus. (PubMed id 12892399)1, 4 Sebastiani G.D....Marcolongo R. (Lupus 2003)
    117. HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites. (PubMed id 14508706)1, 4 Rossman M.D....Monos D. (Am. J. Hum. Genet. 2003)
    118. HLA-DPB1 and chronic beryllium disease: a HuGE review. (PubMed id 12615603)1, 4 McCanlies E.C....Weston A. (Am. J. Epidemiol. 2003)
    119. HLA class II antigens associated with lupus nephritis in Italian SLE patients. (PubMed id 12651073)1, 4 Marchini M....Scorza R. (Hum. Immunol. 2003)
    120. HLA DRB10405-DQB10401 haplotype is associated with autoimmune pancreatitis in the Japanese population. (PubMed id 11984513)1, 4 Kawa S....Kiyosawa K. (Gastroenterology 2002)
    121. The association of specific HLA class I and II alleles with type 1 diabetes among Filipinos. (PubMed id 12445315)1, 4 Bugawan T.L....Erlich H.A. (Tissue Antigens 2002)
    122. Genetic susceptibility to childhood common acute lymphoblastic leukaemia is associated with polymorphic peptide-binding pocket profiles in HLA-DPB1*0201. (PubMed id 12075003)1, 4 Taylor G.M....Eden O.B. (Hum. Mol. Genet. 2002)
    123. HLA and cytokine gene polymorphisms in biliary atresia. (PubMed id 12100571)1, 4 Donaldson P.T....Kelley D. (Liver 2002)
    124. The influence of patient characteristics, disease variables, and HLA alleles on the development of radiographically evident sacroiliitis in juvenile idiopathic arthritis. (PubMed id 11953976)1, 4 FlatA...rre A.9. (Arthritis Rheum. 2002)
    125. HLA class II markers and clinical heterogeneity in Swedish patients with primary biliary cirrhosis. (PubMed id 12144621)1, 4 Wassmuth R....Lindgren S. (Tissue Antigens 2002)
    126. Analysis of HLA in children with gelatin allergy. (PubMed id 12144625)1, 4 Sakaguchi M....Inouye S. (Tissue Antigens 2002)
    127. HLA class II sequence-based typing in normal Saudi individuals. (PubMed id 12445309)1, 4 Al-Hussein K.A....Tilanus M.G. (Tissue Antigens 2002)
    128. Association of HLA-DPB1 gene with endometriosis in women of Guangdong Province in China. (PubMed id 12390706)1, 4 He Y.L....Xu A.L. (Di Yi Jun Yi Da Xue Xue Bao 2002)
    129. Combination of HLA-A and HLA class II alleles controls the susceptibility to rheumatoid arthritis. (PubMed id 11929590)1, 4 Tsuchiya K....Sasazuki T. (Tissue Antigens 2001)
    130. Modeling of HLA class II susceptibility to Type I diabetes reveals an effect associated with DPB1. (PubMed id 11668578)1, 4 Valdes A.M....Thomson G. (Genet. Epidemiol. 2001)
    131. Association of chronic lymphocytic leukemia with specific alleles of the HLA-DR4:DR53:DQ8 haplotype in German patients. (PubMed id 11291046)1, 4 Machulla H.K....Langner J. (Int. J. Cancer 2001)
    132. HLA class II alleles in Chinese patients with hepatocellular carcinoma. (PubMed id 11318984)1, 4 Donaldson P.T....Johnson P.J. (Liver 2001)
    133. HLA class II allele distribution in the Gypsy community of Andalusia, southern Spain. (PubMed id 11260508)1, 4 Ramal L.M....LA^pez-Nevot M.A. (Tissue Antigens 2001)
    134. HLA-DRB1, -DQA1, -DQB1 and DPB1 susceptibility alleles in Cameroonian type 1 diabetes patients and controls. (PubMed id 11532022)1, 4 Mbanya J.C....Mbanya D.N. (Eur. J. Immunogenet. 2001)
    135. Class II HLA associations with autoantibodies in scleroderma: a highly significant role for HLA-DP. (PubMed id 11393660)1, 4 Gilchrist F.C....du Bois R.M. (Genes Immun. 2001)
    136. The biological significance of HLA-DP gene variation in haematopoietic cell transplantation. (PubMed id 11298597)1, 4 Petersdorf E.W....Hansen J.A. (Br. J. Haematol. 2001)
    137. Major histocompatibility locus genetic markers of beryllium sensitization and disease. (PubMed id 11716174)1, 4 Saltini C....Tinelli C. (Eur. Respir. J. 2001)
    138. HLA class II polymorphism in Aka Pygmies and Bantu Congolese and a reassessment of HLA-DRB1 African diversity. (PubMed id 11782272)1, 4 Renquin J....Kaplan C. (Tissue Antigens 2001)
    139. HLA alleles in relation to specific immunity to liver stage antigen-1 from plasmodium falciparum in Gabon. (PubMed id 11294566)1, 4 Migot-Nabias F....Deloron P. (Genes Immun. 2001)
    140. DPB1*8601, a previously unrecognized DPB1 variant in the Caucasoid population. (PubMed id 11556983)1, 2 Bengtsson M. (Tissue Antigens 2001)
    141. Epstein-Barr Virus and HLA-DPB1-*0301 in young adult Hodgkin's disease: evidence for inherited susceptibility to Epstein-Barr Virus in cases that are EBV(+ve). (PubMed id 11401923)1, 4 Alexander F.E....Taylor G.M. (amp 2001)
    142. Allele frequencies and haplotypic associations defined by allelic DNA typing at HLA class I and class II loci in the Japanese population. (PubMed id 11169242)1, 4 Saito S....Ota M. (Tissue Antigens 2000)
    143. The nucleotide sequence of two new DP alleles, DPA1*02015 and DPB1*8401, identified in a Chinese subject. (PubMed id 10958363)1, 2 McTernan C.L.... Barnett A.H. (Tissue Antigens 2000)
    144. Four new DP alleles identified in a study of 500 unrelated bone marrow donor-recipient pairs. (PubMed id 10090623)1, 2 Steiner L.L....Williams T.M. (Tissue Antigens 1999)
    145. Identification of two new DPB1 alleles, DPB1*7701 and *7801, by sequence-based typing. (PubMed id 9756410)1, 2 Voorter C.... van den Berg-Loonen E. (Tissue Antigens 1998)
    146. Identification of a new DPB1 allele (DPB1*7901) by sequence-based typing. (PubMed id 9756411)1, 2 Voorter C....van den Berg-Loonen E. (Tissue Antigens 1998)
    147. Six new DPB1 alleles identified in a study of 1,302 unrelated bone marrow donor-recipient pairs. (PubMed id 9174146)1, 2 Noreen H.J....Begovich A.B. (Tissue Antigens 1997)
    148. DPB1*BR: an Mhc class II DPB1 allele (DPB1*6601) of negroid origin. (PubMed id 8781129)1, 2 Schnittger L.... Meyer C.G. (Immunogenetics 1996)
    149. DPB1*5901a: a novel HLA-DPB1 allele from a Caucasian family with insulin-dependent diabetes mellitus. (PubMed id 8851734)1, 2 Noble J.A.... Erlich H.A. (Tissue Antigens 1996)
    150. Three new DPB1 alleles identified in a Bantu-speaking population from central Cameroon. (PubMed id 8773318)1, 2 Zimmerman P.A.... Begovich A.B. (Tissue Antigens 1996)
    151. Identification of the novel HLA-DPB1*5801 allele detected by sequenced based typing. (PubMed id 7806296)1, 2 Versluis L.F.... Dawkins R.L. (Immunogenetics 1995)
    152. Characterization of a new DPB1 allele (DPB1*5701) isolated from a Caucasian individual. (PubMed id 8525482)1, 2 Mersch G.... Rossau R. (Tissue Antigens 1995)
    153. A novel HLA-DPB1 allele, DPB1*3601 (DPB1*KT). (PubMed id 7817379)1, 2 Ogawa K.... Inoko H. (Tissue Antigens 1994)
    154. Direct sequencing of a novel DPB1 allele (DPB1*5101) of the heterozygote from the membrane of reverse dot blot analysis. (PubMed id 7839356)1, 2 Kaneshige T.... Uchida K. (Tissue Antigens 1994)
    155. A new HLA-DPB1 allele, DPB1*SUT (DPB1*4701). (PubMed id 7912859)1, 2 Koshizaka T.... Inoko H. (Tissue Antigens 1994)
    156. Seven new DPB1 alleles and their population distribution. (PubMed id 8085260)1, 2 Moonsamy P.V....Begovich A.B. (Tissue Antigens 1994)
    157. Identification of a new HLA-DPB1 allele detected by PCR-RFLP and its nucleotide sequence determination by direct sequencing after PCR amplification. (PubMed id 7901923)1, 2 Mizuki N....Geng L. (Tissue Antigens 1993)
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    166. DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression. (PubMed id 2998758)1, 2 Tonnelle C.... Long E.O. (EMBO J. 1985)
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    171. Association of primary biliary cirrhosis with the allele HLA-DPB1*0301 in a German population. (PubMed id 7843712)4, 9 Mella J.G....Volk B.A. (Hepatology 1995)
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    175. Molecular analysis of an HLA-DP mutant cell line selected for its resistance to killing by HLA-DPw2-specific T-cell clones. (PubMed id 8225437)1, 9 Arroyo J.... Sanchez-Perez M. (Immunogenetics 1994)
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    316. HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41. (PubMed id 8084338)1 Chen Y.H....Dierich M.P. (Mol. Immunol. 1994)
    317. Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help. (PubMed id 8168144)1 Chirmule N....Pahwa S. (Cell. Immunol. 1994)
    318. A novel HLA-DPB1 allele (DPB1*4501) in a Dutch Caucasian healthy control. (PubMed id 8236237)1 de Vries N....van de Putte L.B. (Tissue Antigens 1993)
    319. HLA-DPB1 alleles in a population from south China. (PubMed id 8420834)1 Falco M.... Stastny P. (Immunogenetics 1993)
    320. Novel class II HLA-DRB4 and DPB1 alleles found in the Belgian population. (PubMed id 8344726)2 Buyse I.... Cassiman J.J. (Immunogenetics 1993)
    321. A silent mutation in HLA-DPB1*0101 and its evolutionary implications. (PubMed id 8106267)1 Meyer C.G. and Schnittger L. (Hum. Immunol. 1993)
    322. HLA-DPB1 glutamate 69: a genetic marker of beryllium disease. (PubMed id 8105536)1 Richeldi L....Saltini C. (Science 1993)
    323. Nucleotide sequence of a novel DPB1 allele, DPB1*4701. (PubMed id 8244783)1 Mitsunaga S.... Saji H. (Hum. Immunol. 1993)
    324. An analysis with sequence-specific oligonucleotide probes of the association between aspirin-induced asthma and antigens of the HLA system. (PubMed id 8335847)4 Lympany P.A....Lee T.H. (J. Allergy Clin. Immunol. 1993)
    325. HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes. (PubMed id 8376762)1 Callahan K.M....Siliciano R.F. (J. Immunol. 1993)
    326. Identification of CD4 and major histocompatibility complex functional peptide sites and their homology with oligopeptides from human immunodeficiency virus type 1 glycoprotein gp120: role in AIDS pathogenesis. (PubMed id 8356059)1 Zagury J.F....Picard O. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    327. A novel HLA-DPB1 sequence, DPB1*2301. (PubMed id 1412416)1 Eiermann T.H.... Goldmann S.F. (Tissue Antigens 1992)
    328. Characterization of novel HLA-DPB1 alleles by oligotyping and nucleotide sequencing. (PubMed id 1481203)2 Hessner M.J. and Baxter-Lowe L.A. (Tissue Antigens 1992)
    329. DPB1*WA4 - an additional HLA class II allele identified in west Africa. (PubMed id 1412421)2 Meyer C.G.... Horstmann R.D. (Tissue Antigens 1992)
    330. HLA class II nucleotide sequences, 1992. (PubMed id 1362295)1 Marsh S.G. and Bodomer J.G. (Tissue Antigens 1992)
    331. Genetic diversity within the HLA class II region: ten new DPB1 alleles and their population distribution. (PubMed id 1440570)2 Moonsamy P.V.... Begovich A.B. (Tissue Antigens 1992)
    332. Analysis of HLA genotypes and susceptibility to insulin-dependent diabetes mellitus: association maps telomeric to HLA-DP. (PubMed id 1502500)4 Baisch J.M. and Capra J.D. (Scand. J. Immunol. 1992)
    333. HLA-DP region gene polymorphism in primary IgA nephropathy: no association. (PubMed id 1362799)4 Rambausek M....Opelz G. (Nephrol. Dial. Transplant. 1992)
    334. Interaction of CD4 with HLA class II antigens and HIV gp120. (PubMed id 1869305)1 Piatier-Tonneau D....Auffray C. (Immunogenetics 1991)
    335. Positive correlation between oligonucleotide typing and T-cell recognition of HLA-DP molecules. (PubMed id 1713190)1 de Koster H.S.... Termijtelen A. (Immunogenetics 1991)
    336. Frequency of DPB1*0401 is significantly decreased in patients with allergic asthma in a mulatto population. (PubMed id 1774196)4 Caraballo L....Ferrara G.B. (Hum. Immunol. 1991)
    337. Modulation of the HLA class II antigen at a molecular level by maternal serum among cord blood cells and unrelated lymphocytes. (PubMed id 1832848)1 Vanderbeeken Y.E....Lucas A. (Arch. Gynecol. Obstet. 1991)
    338. Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules. (PubMed id 1978941)1 Bowman M.R....Burakoff S.J. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    339. HIV-gp120 can block CD4-class II MHC-mediated adhesion. (PubMed id 1967269)1 Rosenstein Y....Herrmann S.H. (J. Immunol. 1990)
    340. A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis. (PubMed id 2512583)1 Begovich A.B....Erlich H.A. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    341. Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules. (PubMed id 2542966)1 Scholl P....Chatila T. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    342. Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding. (PubMed id 2543930)1 Clayton L.K....Reinherz E.L. (Nature 1989)
    343. Inhibition of CD4+ T cell function by the HIV envelope protein, gp120. (PubMed id 2846691)1 Diamond D.C....Burakoff S.J. (J. Immunol. 1988)
    344. A newly characterized HLA-DP beta-chain allele. Evidence for DP beta heterogeneity within the DPw4 specificity. (PubMed id 2456351)1 Lair B.... Karr R.W. (J. Immunol. 1988)
    345. Expression patterns of MHC class II genes in rabbit tissues indicate close homology to human counterparts. (PubMed id 3474276)1 Kulaga H....Kindt T.J. (J. Immunol. 1987)
    346. Structure and evolution of the HLA class II SX beta gene. (PubMed id 3015787)1 Kappes D.J. and Strominger J.L. (Immunogenetics 1986)
    347. Isolation and allelic polymorphism of cDNA clones and genomic clones of HLA-DP heavy and light chains. (PubMed id 2878910)1 Ando A.... Tsuji K. (Hum. Immunol. 1986)
    348. AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications. (PubMed id 3489470)1 Andrieu J.M....Venet A. (AIDS Res 1986)
    349. A processed pseudogene in an intron of the HLA-DP beta 1 chain gene is a member of the ribosomal protein L32 gene family. (PubMed id 3866218)1 Young J.A.T. and Trowsdale J. (Nucleic Acids Res. 1985)
    350. The genomic organisation and nucleotide sequence of the HLA-SB(DP) alpha gene. (PubMed id 2997750)1 Lawrance S.K.... Weissman S.M. (Nucleic Acids Res. 1985)
    351. Linkage map of two HLA-SB beta and two HLA-SB alpha-related genes: an intron in one of the SB beta genes contains a processed pseudogene. (PubMed id 6088068)1 Trowsdale J.... Travers P. (Cell 1984)
    352. Isolation of a cDNA clone coding for an SB beta-chain. (PubMed id 6325928)1 Gustafsson K....Rask L. (Nature 1984)
    353. Polymerase chain reaction--single-strand conformation polymorphism analysis of polymorphism in DPA1 and DPB1 genes: a simple, economical, and rapid method for histocompatibility testing. (PubMed id 1348744)9 Hoshino S....Sasazuki T. (Hum. Immunol. 1992)
    354. HLA-DPB1 associations differ between DRB1*03 positive anti-Jo-1 and anti-PM-Scl antibody positive idiopathic inflammatory myopathy. (PubMed id 19690132)9 Chinoy H....Cooper R.G. (Rheumatology (Oxford) 2009)
    355. Possible susceptibility of the HLA-DPB1*0402 and HLA-DPB1*04 alleles to unexplained recurrent abortion: analysis by means of polymerase chain reaction-restricted fragment length polymorphism method. (PubMed id 10580605)9 Takakuwa K....Tanaka K. (Am. J. Reprod. Immunol. 1999)
    356. PCR-LIS-SSCP (Low ionic strength single-stranded conformation polymorphism)--a simple method for high-resolution allele typing of HLA-DRB1, -DQB1, and -DPB1. (PubMed id 8681139)9 Maruya E....Yokoyama S. (Genome Res. 1996)
    357. Biochemical analysis of HLA-DP gene products by isoelectric focusing and comparison with cellular and molecular genetic typing results. (PubMed id 7710763)9 Rebmann V....Grosse-Wilde H. (Exp. Clin. Immunogenet. 1995)
    358. HLA-DPB1 polymorphism in Blang and Puyi ethnic groups of southwest China inferred from sequence-based typing. (PubMed id 17971047)9 Wang B....Xiao C. (Tissue Antigens 2008)
    359. Polymorphism in the regulatory regions of the HLA-DPB1 gene. (PubMed id 10566595)9 Varney M.D....Tait B.D. (Hum. Immunol. 1999)
    360. Polymorphism, recombination, and linkage disequilibrium within the HLA class II region. (PubMed id 1727870)9 Begovich A.B....Klitz W. (J. Immunol. 1992)
    361. Molecular analysis of the role of the HLA class II genes DRB1, DQA1, DQB1, and DPB1 in susceptibility to Lyme arthritis. (PubMed id 1679052)9 Ruberti G....Fathman C.G. (Hum. Immunol. 1991)
    362. Beryllium sensitivity is linked to HLA-DP genotype. (PubMed id 11551429)9 Wang Z....Marrone B.L. (Toxicology 2001)
    363. Transmission disequilibrium analysis of HLA class II DRB1, DQA1, DQB1 and DPB1 polymorphisms in schizophrenia using family trios from a Han Chinese population. (PubMed id 11343866)9 Li T....Collier D.A. (Schizophr. Res. 2001)
    364. Dissection of positive regulatory elements in the upstream region of the HLA-DPB1 gene. (PubMed id 7652737)9 Koide Y. and Yoshida T.O. (Tissue Antigens 1995)
    365. HLA class II alleles in isocyanate-induced asthma. (PubMed id 8111601)9 Bignon J.S....Charron D. (Am. J. Respir. Crit. Care Med. 1994)
    366. The relationship between human sperm fertilizing capacity and histocompatibility linked antigen (HLA) alleles gene sequences. (PubMed id 8027284)9 Chan P.J....Tredway D.R. (Hum. Reprod. 1994)
    367. HLA DQ and DP locus mismatches and their effect on MLC in HLA class I- and DRB1-matched unrelated patient/donor pairs waiting for allogeneic bone-marrow transplantation. (PubMed id 8128190)9 Partanen J. and Koskimies S. (Scand. J. Immunol. 1994)
    368. Analysis of HLA DP, DQ, and DR alleles in adult Italian rheumatoid arthritis patients. (PubMed id 1429034)9 Angelini G....Fanetti G. (Hum. Immunol. 1992)
    369. HLA-DPB1 gene polymorphism and multiple sclerosis: a large case-control study in the southwest of France. (PubMed id 1918327)9 Roth M.P....Clanet M. (J. Neuroimmunol. 1991)
    370. HLA-DRB1, -DQA1, -DQB1, -DPA1 and -DPB1 genes in Japanese multiple sclerosis patients. (PubMed id 1926126)9 Spurkland A....Vartdal F. (Tissue Antigens 1991)

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