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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLA-DPB1 Gene

protein-coding   GIFtS: 61
GCID: GC06P033043

Major Histocompatibility Complex, Class II, DP Beta 1


(Previous symbol: HLA-DP1B)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Major Histocompatibility Complex, Class II, DP Beta 11 2     HLA DP14-Beta Chain2
HLA-DP1B1 2 3     HLA-DP Histocompatibility Type, Beta-1 Subunit2
HLA Class II Histocompatibility Antigen, DP(W4) Beta Chain2 3     Major Histocompatibility Complex Class II Antigen Beta Chain2
MHC Class II Antigen DPB12 3     MHC Class II Antigen Beta Chain2
DPB12     MHC Class II Antigen DP Beta 1 Chain2
HLA-DP2     MHC Class II Antigen DPbeta12
HLA-DPB2     MHC Class II HLA-DP-Beta-12
Beta1 Domain MHC Class II HLA DPB2     MHC Class II HLA-DRB12
Class II HLA Beta Chain2     MHC HLA DPB12
HLA Class II Histocompatibility Antigen, DP Beta 1 Chain2     

External Ids:    HGNC: 49401   Entrez Gene: 31152   Ensembl: ENSG000002238657   OMIM: 1428585   UniProtKB: P044403   

Export aliases for HLA-DPB1 gene to outside databases

Previous GC identifers: GC06P033046 GC06P033090 GC06P033151 GC06P032786


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HLA-DPB1 Gene:
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of
an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune
system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen
presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa
and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular
domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule
both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities,
resulting in up to 4 different molecules. (provided by RefSeq, Jul 2008)

GeneCards Summary for HLA-DPB1 Gene: 
HLA-DPB1 (major histocompatibility complex, class II, DP beta 1) is a protein-coding gene. Diseases associated with HLA-DPB1 include berylliosis, and rubella, and among its related super-pathways are Allograft rejection and Phosphorylation of CD3 and TCR zeta chains. An important paralog of this gene is HLA-DRB5.

UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440
Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
(class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the
regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
efficient peptide loading

Gene Wiki entry for HLA-DPB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLA-DPB1 gene promoter:
         GR   Pbx1a   p300   FOXD3   CUTL1   MIF-1   Cdc5   STAT3   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLA-DPB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HLA-DPB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DPB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

HLA-DPB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-DPB1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P033043:  view genomic region     (about GC identifiers)

Start:
33,043,703 bp from pter      End:
33,057,473 bp from pter
Size:
13,771 bases      Orientation:
plus strand

6/7 alternative locations (see all 7):
Chr6+,NT_167246 4,501,243-4,515,019      Chr6+,NT_113891.2 4,487,883-4,501,576      Chr6+,NT_167248 4,276,154-4,289,926     
Chr6+,NT_167244 4,330,504-4,344,264      Chr6+,NT_167245 4,325,042-4,338,804      Chr6+,NT_167249 4,524,207-4,537,977     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen, DP beta 1 chain precursor  
Size: 258 amino acids; 29159 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic
pathway until it reaches the cell membrane for antigen presentation
Sequence caution: Sequence=AAQ12564.1; Type=Frameshift; Positions=39;
1 PDB 3D structure from and Proteopedia for HLA-DPB1:
3LQZ (3D)    
Secondary accessions: A0PFJ7 A5I886 A8YPB3 B5U8B4 B7VF80 B7VF87 B8ZX68 B8ZYT0 B9W5S8 B9W6F7
B9W6F9 C0MPP5 C0MPQ2 C0MPQ3 C0MPQ5 C0MPQ6 C0MPQ7 C4R9J5 C5IZL1 O00259 O19698 O19700 O19702
O19749 O46884 O77952 O98215 O98216 O98217 O98218 O98219 O98222 O98223 P01916 P04232 P13763
P79493 P79608 Q0P0L4 Q0ZFN3 Q14279 Q27S71 Q29682 Q29684 Q29698 Q29714 Q29775 Q29776 Q29778
Q29779 Q29781 Q29827 Q29828 Q29879 Q29880 Q29898 Q29977 Q2MGW3 Q30015 Q30031 Q30032 Q30033
Q30034 Q30050 Q30051 Q30052 Q30053 Q30054 Q30055 Q30174 Q4GY31 Q4JHD8 Q5ENE0 Q5ENE1 Q5ENW3
Q5EP46 Q5EP47 Q5EP49 Q5EP51 Q5EP52 Q5EP53 Q5EP56 Q5I4H8 Q5I4H9 Q5ISH4 Q5ISH5 Q5SQ73 Q5STP2
Q5YLA6 Q6IVX1 Q6LBX2 Q6LBX3 Q6LBX4 Q6LBX5 Q6LBX6 Q6LBX7 Q6PWX6 Q6TAS4 Q714U1 Q714U2 Q7YQ10
Q860Z7 Q8HWL7 Q8HWT5 Q8SNC4 Q95HC1 Q95IT7 Q95IT8 Q9BD13 Q9GIM2 Q9GIM4 Q9GIX6 Q9GJ41 Q9MY67
Q9TNT7 Q9TQE2 Q9XS11 Q9XS12

Explore the universe of human proteins at neXtProt for HLA-DPB1: NX_P04440

Explore proteomics data for HLA-DPB1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P04440

  • HLA-DPB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HLA-DPB1 Protein Expression
    REFSEQ proteins: NP_002112.3  
    ENSEMBL proteins: 
     ENSP00000408146   ENSP00000412654   ENSP00000399832   ENSP00000439674  
    Reactome Protein details: P04440
    Human Recombinant Protein Products for HLA-DPB1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HLA-DPB1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for HLA-DPB1
    GenScript Custom Purified and Recombinant Proteins Services for HLA-DPB1
    Novus Biologicals HLA-DPB1 Proteins
    Novus Biologicals HLA-DPB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005765lysosomal membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane IEA--
    GO:0012507ER to Golgi transport vesicle membrane TAS--

    HLA-DPB1 for ontologies           About GeneDecksing



    HLA-DPB1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    OriGene Custom Antibody Services for HLA-DPB1
    GenScript Custom Superior Antibodies Services for HLA-DPB1
    Novus Biologicals HLA-DPB1 Antibodies
    Abcam antibodies for HLA-DPB1
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for HLA-DPB1
    LSBio Antibodies in human, mouse, rat for HLA-DPB1 

    Assay Products for HLA-DPB1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HLA-DPB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HLA-DPB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HLA: Histocompatibility complex
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    5/7 InterPro protein domains (see all 7):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR000353 MHC_II_b_N
     IPR013783 Ig-like_fold
     IPR014745 MHC_II_a/b_N
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry P04440

    ProtoNet protein and cluster: P04440

    3 Blocks protein domains:
    IPB000353 Class II histocompatibility antigen
    IPB001003 MHC Class II alpha chain
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    HLA-DPB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPB1_HUMAN, P04440
    Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
    and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
    peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
    of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
    hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
    via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
    As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
    contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
    endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
    MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
    epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
    tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
    an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
    of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
    degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
    (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
    the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
    affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
    membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
    Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the
    regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
    efficient peptide loading

         Genatlas biochemistry entry for HLA-DPB1:
    HLA-DP,beta chain

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    HLA-DPB1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HLA-DPB1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HLA-DPB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HLA-DPB1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HLA-DPB1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-DPB1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HLA-DPB1:
    hsa-miR-767-3p hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidHLA-DPB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HLA-DPB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-DPB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HLA-DPB1
    Sirion Biotech Customized adenovirus for overexpression of HLA-DPB1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HLA-DPB1 (see all 8)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLA-DPB1 (NM_002121)
    Sino Biological Human cDNA Clone for HLA-DPB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-DPB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DPB1
    Sirion Biotech Customized lentivirus for stable overexpression of HLA-DPB1 
                         Customized lentivirus expression plasmids for stable overexpression of HLA-DPB1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HLA-DPB1
    Search LifeMap BioReagents cell lines for HLA-DPB1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DPB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HLA-DPB1 About   (see all 24)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Allograft rejection
    Allograft rejection0.69
    Asthma0.47
    Type I diabetes mellitus0.69
    Intestinal immune network for IgA production0.42
    Graft-versus-host disease0.65
    Antigen processing and presentation0.37
    Autoimmune thyroid disease0.62
    Viral myocarditis0.35
    2Translocation of ZAP-70 to Immunological synapse
    Translocation of ZAP-70 to Immunological synapse0.85
    PD-1 signaling0.77
    Phosphorylation of CD3 and TCR zeta chains0.85
    Generation of second messenger molecules0.64
    3Interferon Signaling
    Interferon Signaling0.61
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.61
    4Leishmaniasis
    Leishmaniasis0.36
    Inflammatory bowel disease (IBD)0.34
    Toxoplasmosis0.36
    5TCR signaling
    TCR signaling0.75
    Downstream TCR signaling0.75

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for HLA-DPB1 (see all 6)
        Immune response Antigen presentation by MHC class II
    G-protein signaling N-RAS regulation pathway
    Immune response IL-22 signaling pathway
    Immune response NFAT in immune response
    Immune response ICOS pathway in T-helper cell


    5/6 GeneGo (Thomson Reuters) Pathways for HLA-DPB1 (see all 6)
        Immune response Antigen presentation by MHC class II
    Immune response ICOS pathway in T-helper cell
    Immune response T cell receptor signaling pathway
    Immune response IL-22 signaling pathway
    G-protein signaling N-RAS regulation pathway

    1 Sino Biological Pathway for HLA-DPB1 
        NF-kB (NFkB) Pathway

    5/13        Reactome Pathways for HLA-DPB1 (see all 13)
        Interferon gamma signaling
    Costimulation by the CD28 family
    Cytokine Signaling in Immune system
    Adaptive Immune System
    Translocation of ZAP-70 to Immunological synapse


    5/21         Kegg Pathways  (Kegg details for HLA-DPB1) (see all 21):
        Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Intestinal immune network for IgA production
    Type I diabetes mellitus


    HLA-DPB1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLA-DPB1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/11 Interacting proteins for HLA-DPB1 (P044402, 3 ENSP000004081464) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ROBO2Q9HCK42, 3MINT-8258142 I2D: score=2 
    RTN4Q9NQC32, 3MINT-8258153 I2D: score=2 
    HLA-DPA1P200363, ENSP000003935664I2D: score=1 STRING: ENSP00000393566
    ENSG00000168384P200363I2D: score=1 
    ENSG00000206291P200363I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002504antigen processing and presentation of peptide or polysaccharide antigen via MHC class II ----
    GO:0006955immune response ----
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0019882antigen processing and presentation ----
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    HLA-DPB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HLA-DPB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HLA-DPB1 (DPB1)

    4 Novoseek inferred chemical compound relationships for HLA-DPB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpa 1 96.1 37 11556979 (4), 1348744 (3), 7710763 (2), 8225437 (2) (see all 15)
    beryllium 66.1 7 10415070 (2), 11551429 (2), 10860658 (1), 14662898 (1)
    oligonucleotide 30.5 6 8436419 (1), 8863870 (1), 10566595 (1), 1971269 (1) (see all 5)
    glutamate 0 1 11551429 (1)

    Search CenterWatch for drugs/clinical trials and news about HLA-DPB1 / DPB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HLA-DPB1 gene: 
    NM_002121.5  

    Unigene Cluster for HLA-DPB1:

    Major histocompatibility complex, class II, DP beta 1
    Hs.485130  [show with all ESTs]
    Unigene Representative Sequence: NM_002121
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418931(uc003ocu.2 uc011dqo.2) ENST00000469120 ENST00000471184
    ENST00000488575 ENST00000498038 ENST00000428835 ENST00000416804(uc011dqq.1)
    ENST00000478189 ENST00000535465(uc011dqn.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HLA-DPB1:
    hsa-miR-767-3p hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmidHLA-DPB1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HLA-DPB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-DPB1
    Clone
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    OriGene clones in human, mouse for HLA-DPB1 (see all 8)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLA-DPB1 (NM_002121)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-DPB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DPB1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DPB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DPB1

    Additional mRNA sequence: 

    AB208978.1 AK291986.1 AK301322.1 AK303153.1 AK313305.1 AY656678.1 AY656679.1 AY656680.1 
    AY804132.1 AY804133.1 AY804134.1 AY804135.1 AY804136.1 AY804137.1 AY804138.1 AY804139.1 
    AY804140.1 AY804141.1 AY804142.1 AY804143.1 AY831401.1 AY831402.1 AY831403.1 AY831404.1 
    BC007963.2 BC013184.1 BC015000.1 BT019780.1 DQ284441.1 FR775797.1 FR775798.1 GQ891549.1 
    HE603611.1 HE603612.1 HE614584.1 HE614585.1 HE614586.1 HE614587.1 HE614588.1 HE614589.1 
    HE614590.1 HE614591.1 J03041.1 K00409.1 K01615.1 L29173.1 M21886.1 M28200.1 
    M28201.1 M28202.1 M57466.1 M83664.1 S66883.1 S79786.1 X00532.1 X01426.1 
    X03067.1 

    24/35 DOTS entries (see all 35):

    DT.100826689  DT.91878430  DT.91791833  DT.452653  DT.100826691  DT.95269923  DT.40127111  DT.75122389 
    DT.121402840  DT.121402869  DT.104576  DT.300839  DT.97800984  DT.101961746  DT.121402689  DT.86858814 
    DT.91661820  DT.91761305  DT.95338993  DT.100044867  DT.121402700  DT.121402836  DT.121402845  DT.91720260 

    24/599 AceView cDNA sequences (see all 599):

    BQ066305 NM_002121 AI299015 AA336524 BC017967 BF724819 AA613066 BX279593 
    AW951201 BF057731 AI433575 AA778424 M28202 BI062287 AA363729 BF589519 
    CD368932 BQ061242 AA507462 BM665426 AA456492 CA309047 AA364192 BX102440 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HLA-DPB1 expression in normal human tissues (normalized intensities)      HLA-DPB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCCTTCTT
    HLA-DPB1 Expression
    About this image


    HLA-DPB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
     
     Lymph (Hematopoietic System)
             LYMPH NODE   
     
     Tonsil (Hematopoietic System)
     
     Spleen (Hematopoietic System)

    See HLA-DPB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HLA-DPB1

    SOURCE GeneReport for Unigene cluster: Hs.485130
        SABiosciences Custom PCR Arrays for HLA-DPB1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HLA-DPB1
    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-DPB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HLA-DPB1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DPB1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DPB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DPB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-DPB1 gene from 4/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia HLA-DPB16
    major histocompatibility complex, class II, DP bet...
    49(a)
    1 ↔ 1
    12(2604546-2607784)
    chicken
    (Gallus gallus)
    Aves --
    BLB16
    MHC class II beta chain precursor
    47(a)
    46(a)
    many ↔ many
    many ↔ many
    AADN03010751.1(32-1186)
    16(102122-103266)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    41(a)
    1 → many
    GL343520.1(320149-320904)
    zebrafish
    (Danio rerio)
    Actinopterygii si:zfos-2070c2.36
    wu:fd58b116
    (see all 10)
    wu:fd58b11
    (see all 10)
    37(a)
    30(a)
    (see all 10)
    many ↔ many
    many ↔ many
    (see all 10)
    8(37510422-37511403)
    4(61874514-61880599)


    ENSEMBL Gene Tree for HLA-DPB1 (if available)
    TreeFam Gene Tree for HLA-DPB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HLA-DPB1 gene
    HLA-DRB52  HLA-DQA12  HLA-DPA12  HLA-DQB12  HLA-DRA2  HLA-DRB12  HLA-DOB2  HLA-DMA2  
    HLA-DQB22  HLA-DOA2  ENSG000002489932  HLA-DMB2  HLA-DQA22  
    18/114 SIMAP similar genes for HLA-DPB1 using alignment to 235 protein entries:     DPB1_HUMAN (see all proteins) (see all similar genes):
    HLA-SB beta    HLA-DPB    HLA-DP    DPB1    MHC DPB1    HLA-DB1
    MHC-DPB1*6001    HLA-D8.2V    HLA-DRB13     HLA-DBR1    HLQ-DQB1    HLA-DRB1*1327
    HLA-DRB4*0102    HLA-DRB14    HLA-DRB1*0801    HLA-DRB1*11    HLA-DRB1*1605    HLA-DRB1*1125

    HLA-DPB1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for HLA-DPB1
    PGOHUM00000260171 PGOHUM00000260853


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440
    Polymorphism: The following alleles of HLA-DPB1 are known: DPB1*01:01, DPB1*01:02, DPB1*02:01, DPB1*02:02,
    DPB1*02:03, DPB1*03:01, DPB1*03:02, DPB1*04:01, DPB1*04:02, DPB1*04:03, DPB1*05:01, DPB1*05:02, DPB1*06:01,
    DPB1*06:02, DPB1*08:01, DPB1*08:02, DPB1*09:01, DPB1*09:02, DPB1*10:01, DPB1*10:02, DPB1*11:01, DPB1*11:02,
    DPB1*13:01, DPB1*13:02, DPB1*14:01, DPB1*14:02, DPB1*15:01, DPB1*15:02, DPB1*16:01, DPB1*16:02, DPB1*17:01,
    DPB1*17:02, DPB1*18:01, DPB1*18:02, DPB1*19:01, DPB1*19:02, DPB1*20:01, DPB1*20:02, DPB1*21:01, DPB1*21:02,
    DPB1*22:01, DPB1*22:02, DPB1*23:01, DPB1*24:01, DPB1*24:02, DPB1*25:01, DPB1*25:02, DPB1*26:01, DPB1*26:02,
    DPB1*27:01, DPB1*28:01, DPB1*29:01, DPB1*30:01, DPB1*31:01, DPB1*32:01, DPB1*33:01, DPB1*34:01, DPB1*35:01,
    DPB1*36:01, DPB1*37:01, DPB1*38:01, DPB1*39:01, DPB1*40:01, DPB1*41:01, DPB1*44:01, DPB1*45:01, DPB1*46:01,
    DPB1*47:01, DPB1*48:01, DPB1*49:01, DPB1*50:01, DPB1*51:01, DPB1*52:01, DPB1*53:01, DPB1*54:01, DPB1*55:01,
    DPB1*56:01, DPB1*57:01, DPB1*58:01, DPB1*59:01, DPB1*60:01, DPB1*62:01, DPB1*63:01, DPB1*65:01, DPB1*66:01,
    DPB1*67:01, DPB1*68:01, DPB1*69:01, DPB1*70:01, DPB1*71:01, DPB1*72:01, DPB1*73:01, DPB1*74:01, DPB1*75:01,
    DPB1*76:01, DPB1*77:01, DPB1*78:01, DPB1*79:01, DPB1*80:01, DPB1*81:01, DPB1*82:01, DPB1*83:01, DPB1*84:01,
    DPB1*85:01, DPB1*86:01, DPB1*87:01, DPB1*88:01, DPB1*89:01, DPB1*90:01, DPB1*91:01, DPB1*92:01, DPB1*93:01,
    DPB1*94:01, DPB1*95:01, DPB1*96:01, DPB1*97:01, DPB1*98:01 and DPB1*99:01. The sequence shown is that of
    DPB1*04:01


    10/493 SNPs in HLA-DPB1 are shown (see all 493)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10421401,2,4
    C,Fother132964610(+) AGGAGA/C/G/
            
    AGCGG
    2 K E mis110MN NA WA CSA EA EU 6274
    VAR_0606304
    ----see VAR_0606302 A L mis40--------
    VAR_0606414
    ----see VAR_0606412 A T mis40--------
    VAR_0334344
    ----see VAR_0334342 G V mis40--------
    VAR_0606374
    ----see VAR_0606372 G L mis40--------
    VAR_0606384
    ----see VAR_0606382 R L mis40--------
    VAR_0606424
    ----see VAR_0606422 Y D mis40--------
    VAR_0606544
    ----see VAR_0606542 P L mis40--------
    VAR_0606484
    ----see VAR_0606482 E V mis40--------
    VAR_0595124
    ----see VAR_0595122 I F mis40--------

    HapMap Linkage Disequilibrium report for HLA-DPB1 (33043703 - 33057473 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/15 variations for HLA-DPB1 (see all 15):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2731879CNV Deletion23290073
    dgv1047e201CNV Deletion23290073
    esv22467CNV Loss19812545
    dgv6828n71CNV Loss21882294
    dgv1042n67CNV Loss20364138
    nsv823656CNV Loss20364138
    nsv516221CNV Loss19592680
    dgv1041n67CNV Loss20364138
    nsv885759CNV Loss21882294
    nsv823645CNV Loss20364138


    Human Gene Mutation Database (HGMD): HLA-DPB1

    Locus Specific Mutation Databases (LSDB): HLA-DPB1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HLA-DPB1
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-DPB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142858    OMIM disorders: --

    20/93 diseases for HLA-DPB1 (see all 93):    About MalaCards
    berylliosis    rubella    coronary artery aneurysm    chronic thromboembolic pulmonary hypertension
    neuromyelitis optica    autoimmune pancreatitis    myelitis    takayasu's arteritis
    myasthenia gravis    mumps    graft versus host disease    cutaneous leishmaniasis
    juvenile rheumatoid arthritis    silicosis    mixed connective tissue disease    toxic shock syndrome
    type 1 diabetes    deep vein thrombosis    hematopoietic stem cell transplantation    acute graft versus host disease


    HLA-DPB1 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for HLA-DPB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beryllium disease chronic 77.6 3 10415070 (1), 10860658 (1), 14662898 (1)
    genetic susceptibility 52.7 6 11975985 (1), 17060025 (1), 1980918 (1), 7843712 (1) (see all 5)
    arthritis juvenile rheumatoid 40.5 1 8436419 (1)
    diabetes mellitus insulin-dependent 32.3 3 11592043 (3)
    myasthenia gravis 18.1 2 8357200 (1), 7749041 (1)
    graft-versus-host disease 13.6 1 8932283 (1)
    systemic disease 9.97 1 10616003 (1)
    lupus erythematosus systemic 7.62 1 8456439 (1)
    multiple sclerosis 3.56 3 1918327 (2), 1926126 (1)
    rheumatoid arthritis 0 2 1429034 (1), 1822107 (1)

    Genetic Association Database (GAD): HLA-DPB1
    Human Genome Epidemiology (HuGE) Navigator: HLA-DPB1 (168 documents)

    Export disorders for HLA-DPB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HLA-DPB1 gene, integrated from 9 sources (see all 416) (see top 10):
    (articles sorted by number of sources associating them with HLA-DPB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Extended HLA-DPB1 polymorphism: an RNA approach for HLA-DPB1 typing. (PubMed id 16189666)1, 2, 9 Reinders J.... Tilanus M.G.J. (2005)
    2. HLA-DPA1 and DPB1 polymorphism in four Pacific Islands populations determined by sequencing based typing. (PubMed id 11556979)1, 4, 9 Velickovic Z.M. and Carter J.M. (2001)
    3. Polymorphism of human leukocyte antigen-DRB1, -DQB1, and -DPB1 genes of Shandong Han population in China. (PubMed id 15982255)1, 4, 9 Zhou L....Xu A. (2005)
    4. Molecular analyses of HLA-DRB1, -DPB1, and -DQB1 in Jing ethnic minority of Southwest China. (PubMed id 12878363)1, 4, 9 Lin J.H....Xu A.L. (2003)
    5. Polymorphism of HLA-DRB1, -DQB1 and -DPB1 genes in Bai ethnic group in southwestern China. (PubMed id 18778327)1, 4, 9 Hu W....Xiao C. (2008)
    6. [Sequencing-based typing of HLA-DPB1 and DQB1 exon 2 in patients with type 1 diabetes mellitus] (PubMed id 11592043)1, 4, 9 Zhang S....Jiang Z. (2001)
    7. Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controls. (PubMed id 18486765)1, 4, 9 Noble J.A....Erlich H.A. (2008)
    8. Association of HLA class II DRB1, DPA1 and DPB1 polymorphism with genetic susceptibility to idiopathic dilated cardiomyopathy in Chinese Han nationality. (PubMed id 17060025)1, 4, 9 Liu W....Gan R.T. (2006)
    9. Analysis of the role of DPB1-encoded amino acids in the genetic predisposition to type I diabetes mellitus. (PubMed id 11975985)1, 4, 9 Rayner M.L....Barnett A.H. (2002)
    10. Two new HLA DPB1 alleles identified by sequence-based typing: DPB1*8201 and DPB1*8301. (PubMed id 11169249)1, 2, 9 Voorter C.... van den Berg-Loonen E. (2000)
    11. Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease. (PubMed id 14662898)1, 4, 9 Maier L.A....Newman L.S. (2003)
    12. Effect of human leukocyte antigen homozygosity on rub ella vaccine-induced humoral and cell-mediated immune responses. (PubMed id 19896518)1, 4, 9 Kennedy R.B....Poland G.A. (2010)
    13. Association of the HLA-DPB1*0501 allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders. (PubMed id 19140826)1, 4, 9 Matsushita T....Kira J. (2009)
    14. HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis. (PubMed id 19165231)1, 4, 9 Kominami S....Kimura A. (2009)
    15. Analysis of maternal-offspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes. (PubMed id 19143818)1, 4, 9 Bronson P.G....Barcellos L.F. (2009)
    16. Association of TNF-alpha genetic polymorphism with HLA DPB1*0301. (PubMed id 17014432)1, 4, 9 Kim S.H....Park H.S. (2006)
    17. Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan. (PubMed id 12464650)1, 4, 9 Hildesheim A....Erlich H.A. (2002)
    18. HLA class I and class II allele and haplotype diversity in Martinicans. (PubMed id 11285127)1, 4, 9 Bera O....Semana G. (2001)
    19. Genetic susceptibility to breast cancer: HLA DQB*03032 and HLA DRB1*11 may represent protective alleles. (PubMed id 11027344)1, 4, 9 Chaudhuri S....Pillai S. (2000)
    20. A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region. (PubMed id 21764829)1, 4 Png E....Seielstad M. (2011)
    21. Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers i n the Han Chinese population. (PubMed id 21274863)1, 4 Guo X....O'Brien S.J. (2011)
    22. Identification of novel genetic markers associated wit h clinical phenotypes of systemic sclerosis through a genome-wide association st rategy. (PubMed id 21779181)1, 4 Gorlova O....Martin J. (2011)
    23. Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. (PubMed id 21814517)1, 4 Noguchi E....Matsumoto K. (2011)
    24. A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. (PubMed id 21750111)1, 4 Mbarek H....Matsuda K. (2011)
    25. HLA and CTLA4 polymorphisms may confer a synergistic risk in the susceptibility to Graves' disease. (PubMed id 20300120)1, 4 Takahashi M. and Kimura A. (2010)
    26. A polymorphism in the HLA-DPB1 gene is associated wit h susceptibility to multiple sclerosis. (PubMed id 21049023)1, 4 Field J....Stankovich J. (2010)
    27. Juvenile idiopathic arthritis and HLA class I and cla ss II interaction and age of onset effects. (PubMed id 20191588)1, 4 Glass D.N. (2010)
    28. HLA DPA1, DPB1 alleles and haplotypes contribute to t he risk associated with type 1 diabetes: analysis of the type 1 diabetes geneti cs consortium families. (PubMed id 20424227)1, 4 Varney M.D....Erlich H. (2010)
    29. Association between HLA-B*4001 and lipodystrophy amon g HIV-infected patients from Thailand who received a stavudine-containing antir etroviral regimen. (PubMed id 20073992)1, 4 Wangsomboonsiri W....Sungkanuparph S. (2010)
    30. HLA genotyping in the international Type 1 Diabetes G enetics Consortium. (PubMed id 20595243)1, 4 Mychaleckyj J.C....Erlich H.A. (2010)
    31. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    32. Major histocompatibility complex (MHC) class II allel es, haplotypes and epitopes which confer susceptibility or protection in system ic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases a nd 1000 controls. (PubMed id 19596691)1, 4 Arnett F.C....Reveille J.D. (2010)
    33. Refining the association of MHC with multiple scleros is in African Americans. (PubMed id 20466734)1, 4 McElroy J.P....Gourraud P.A. (2010)
    34. Replication of rubella vaccine population genetic stu dies: validation of HLA genotype and humoral response associations. (PubMed id 19761839)1, 4 Ovsyannikova I.G....Poland G.A. (2009)
    35. HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients. (PubMed id 19104471)1, 4 Chantarangsu S....Nakamura Y. (2009)
    36. HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms. (PubMed id 19180512)1, 4 Lin Y.J....Tsai F.J. (2009)
    37. Strong association of the HLA-DP6 supertype with childhood leukaemia is due to a single allele, DPB1*0601. (PubMed id 19148140)1, 4 Taylor G.M....Birch J.M. (2009)
    38. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (2009)
    39. Association of susceptibility to multiple sclerosis i n Southern Han Chinese with HLA-DRB1, -DPB1 alleles and DRB1-DPB1 haplotypes: d istinct from other populations. (PubMed id 19965521)1, 4 Wu X.M....Gong L.Y. (2009)
    40. Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. (PubMed id 19143813)1, 4 Howson J.M....Todd J.A. (2009)
    41. HLA-DPB1 and DPB2 are genetic loci for systemic scler osis: a genome-wide association study in Koreans with replication in North Amer icans. (PubMed id 19950302)1, 4 Zhou X....Lee E.B. (2009)
    42. TNF and LTA Gene, Allele, and Extended HLA Haplotype Associations with Severe Dengue Virus Infection in Ethnic Thais. (PubMed id 19392621)1, 4 Vejbaesya S....Stephens H.A. (2009)
    43. HLA-A disparities illustrate challenges for ranking t he impact of HLA mismatches on bone marrow transplant outcomes in the United St ates. (PubMed id 19589487)1, 4 Baxter-Lowe L.A....Hurley C.K. (2009)
    44. HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine. (PubMed id 19200828)1, 4 Ovsyannikova I.G....Poland G.A. (2009)
    45. Is neuromyelitis optica associated with human leukocyte antigen? (PubMed id 19299434)1, 4 ZAcphir H....de Seze J. (2009)
    46. The HLA DRB1*1501-DQB1*0602-DPB1*0501 haplotype is a risk factor for toluene diisocyanate-induced occupational asthma. (PubMed id 19439981)1, 4 Choi J.H....Park H.S. (2009)
    47. A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. (PubMed id 19349983)1, 4 Kamatani Y....Matsuda K. (2009)
    48. Clinical and immunogenetic prognostic factors for rad iographic severity in ankylosing spondylitis. (PubMed id 19565552)1, 4 Ward M.M....Weisman M.H. (2009)
    49. Inhibitor-Immunology-Study. Different HLA-types seem to be involved in the inhibitor development in haemophilia A. (PubMed id 18958335)1, 4 Wieland I....Sykora K.W. (2008)
    50. Impact of HLA-DPB1 allelic and single amino acid mismatches on HSCT. (PubMed id 18544086)1, 4 Ludajic K....Greinix H.T. (2008)
    51. HLA mismatch combinations associated with decreased risk of relapse: Implications for molecular mechanism. (PubMed id 18997170)1, 4 Kawase T....Morishima Y. (2008)
    52. HLA-DPbeta chain may confer the susceptibility to hepatitis C virus-associated hypertrophic cardiomyopathy. (PubMed id 18186799)1, 4 Shichi D....Kimura A. (2008)
    53. The clinical implications of HLA mismatches in unrelated donor haematopoietic cell transplantation. (PubMed id 18976440)1, 4 Shaw B.E. (2008)
    54. Anti-cofactor autoantibodies in systemic lupus erythematosus: prevalence, clinical and HLA class II associations. (PubMed id 18569076)1, 4 Sebastiani G.D....Galeazzi M. (2008)
    55. HLA-DQB1 and -DPB1 allele profile in HIV infected patients with and without pulmonary tuberculosis of south India. (PubMed id 18652916)1, 4 Selvaraj P....Narayanan P.R. (2008)
    56. Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus. (PubMed id 18309376)1, 4 Lee H.S....Gregersen P.K. (2008)
    57. HLA-associated susceptibility to childhood B-cell precursor ALL: definition and role of HLA-DPB1 supertypes. (PubMed id 18334973)1, 4 Taylor G.M....Greaves M.F. (2008)
    58. Some but not all of HLA-II alleles are associated with cervical cancer in Chinese women. (PubMed id 19027490)1, 4 Liang J....Lin Z. (2008)
    59. The Wegener's granulomatosis quantitative trait locus on chromosome 6p21.3 as characterised by tagSNP genotyping. (PubMed id 17967832)1, 4 Heckmann M....Wieczorek S. (2008)
    60. Conditional analyses on the T1DGC MHC dataset: novel associations with type 1 diabetes around HLA-G and confirmation of HLA-B. (PubMed id 18830248)1, 4 Eike M.C....Lie B.A. (2008)
    61. Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis. (PubMed id 18952831)1, 4 Matsuoka T....Kira J. (2008)
    62. HLA-A, B, Cw, DRB1, DQB1 and DPB1 alleles and haplotypes in the genetically homogenous Irish population. (PubMed id 18976432)1, 4 Dunne C....Lawlor E. (2008)
    63. High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism. (PubMed id 17554059)1, 4 Kawase T....Sasazuki T. (2007)
    64. Synergistic contribution of CD14 and HLA loci in the susceptibility to Buerger disease. (PubMed id 17653770)1, 4 Chen Z....Kimura A. (2007)
    65. The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation. (PubMed id 17726164)1, 4 Shaw B.E....Petersdorf E.W. (2007)
    66. [Association of HLA-DRB1 and -DPB1 allele polymorphism with multiple sclerosis in Chinese Han population from Southern areas] (PubMed id 18167262)1, 4 Wu X.M....Xie X.F. (2007)
    67. HLA class II polymorphisms associated with the physiologic characteristics defined by Traditional Chinese Medicine: linking modern genetics with an ancient medicine. (PubMed id 17388766)1, 4 Chen S....Xu A. (2007)
    68. HPV16 E6 variants and HLA class II polymorphism among Chinese women with cervical cancer. (PubMed id 17311339)1, 4 Wu Y....Xu A. (2007)
    69. Effects of HLA allele and killer immunoglobulin-like receptor ligand matching on clinical outcome in leukemia patients undergoing transplantation with T-cell-replete marrow from an unrelated donor. (PubMed id 17317585)1, 4 Morishima Y....Kodera Y. (2007)
    70. Human leukocyte antigen class II alleles and risk of cervical cancer in China. (PubMed id 17349874)1, 4 Wu Y....Xu A. (2007)
    71. HLA-DPB1*0402 protects against type 1A diabetes autoimmunity in the highest risk DR3-DQB1*0201/DR4-DQB1*0302 DAISY population. (PubMed id 17513705)1, 4 Baschal E.E....Eisenbarth G.S. (2007)
    72. HLA class II amino acid epitopes as susceptibility markers of sarcoidosis. (PubMed id 17559577)1, 4 Voorter C.E....van den Berg-Loonen E.M. (2007)
    73. Association of immune responses to mycobacterium tuberculosis peptide antigens with host genetic factors. (PubMed id 17153701)1, 4 Saad A.H....Zakaria Z. (2006)
    74. Interaction of loci within the HLA region influences multiple sclerosis course in the Sardinian population. (PubMed id 16096810)1, 4 Marrosu M.G....Contu P. (2006)
    75. HLA DRB1*15-DPB1*05 haplotype: a susceptible gene mar ker for isocyanate-induced occupational asthma? (PubMed id 16792590)1, 4 Kim S.H....Park H.S. (2006)
    76. Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine. (PubMed id 16453260)1, 4 Ovsyannikova I.G....Poland G.A. (2006)
    77. Association of HLA-DPB1 alleles with type I diabetes mellitus in Slovak population. (PubMed id 16796127)1, 4 Stuchlikova M....Buc M. (2006)
    78. HLA-DPB1*0202 is associated with a predictor of good prognosis of Graves' disease in the Japanese. (PubMed id 16698425)1, 4 Takahashi M....Kimura A. (2006)
    79. HLA-DPB1 matching status has significant implications for recipients of unrelated donor stem cell transplants. (PubMed id 16234356)1, 4 Shaw B.E....Madrigal J.A. (2006)
    80. Class II HLA allele polymorphism: DRB1, DQB1 and DPB1 alleles and haplotypes in the New Zealand Maori population. (PubMed id 17026464)1, 4 Tracey M.C. and Carter J.M. (2006)
    81. HLA-dPB1*0501 is not uniquely associated with opticospinal multiple sclerosis in Japanese patients. Important role of DPB1*0301. (PubMed id 16459716)1, 4 Fukazawa T....Sasaki H. (2006)
    82. Identification of a novel HLA-DPB1 allele, DPB1*1702. (PubMed id 16866899)1, 2 Li M.... Yu X. (2006)
    83. The prevalence of human leukocyte antigen (HLA) DR/DQ/DP alleles in Kuwaiti children with oligoarticular juvenile idiopathic arthritis. (PubMed id 15703957)1, 4 Alsaeid K....Ayoub E.M. (2006)
    84. High-resolution molecular characterization of the HLA class I and class II in the Tarahumara Amerindian population. (PubMed id 16866883)1, 4 Garcia-Ortiz J.E....Arguello J.R. (2006)
    85. Alteration of the influences of HLA classes I and II alleles on the perinatal hepatitis B virus infection after immunoprophylaxis in Korean children. (PubMed id 16890179)1, 4 Kim J.H....Kim T.G. (2006)
    86. HLA class II alleles and measles virus-specific cytokine immune response following two doses of measles vaccine. (PubMed id 15712014)1, 4 Ovsyannikova I.G....Poland G.A. (2005)
    87. The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria. (PubMed id 15784113)1, 4 Kim S.H....Park H.S. (2005)
    88. Association of clinical features with HLA in chronic pulmonary thromboembolism. (PubMed id 15640334)1, 4 Tanabe N....Kuriyama T. (2005)
    89. The DR4-DQ8 haplotype and a specific T cell receptor Vbeta T cell subset are associated with absence of allergy to Can f 1. (PubMed id 15969672)1, 4 Kinnunen T....Virtanen T. (2005)
    90. Human leukocyte antigen class II alleles and rubella-specific humoral and cell-mediated immunity following measles-mumps-rubella-II vaccination. (PubMed id 15655774)1, 4 Ovsyannikova I.G....Poland G.A. (2005)
    91. DNA-sequence determination of exon 2 of a novel HLA-DPB1 allele, HLA- DPB1*0403. (PubMed id 16147881)1, 2 Weston A.... Frye B.L. (2005)
    92. Identification of a new allele in a Sicilian individual: HLA- DPB1*0302. (PubMed id 15982263)1, 2 Sheldon M.H.... Sortino G. (2005)
    93. HLA alleles and risk of cervical intraepithelial neoplasia among southwestern American Indian women. (PubMed id 16386646)1, 4 Schiff M.A....Becker T.M. (2005)
    94. HLA-DPB1 mismatch and acute graft-versus host disease in HLA-identical sibling donors. (PubMed id 17977207)1, 4 Mosaad Y.M. and Kamel H. (2005)
    95. Function associated transforming growth factor-beta gene polymorphism in chronic beryllium disease. (PubMed id 15750822)1, 4 Gaede K.I....Muller-Quernheim J. (2005)
    96. Anti-caspase-8 autoantibody response in silicosis patients is associated with HLA-DRB1, DQB1 and DPB1 alleles. (PubMed id 15703453)1, 4 Ueki A....Kusaka M. (2005)
    97. HLA-DP polymorphism in Venezuelan Amerindians. (PubMed id 15603877)1, 4 Gendzekhadze K....Layrisse Z. (2004)
    98. Identification of a novel HLA-DPB1 allele--DPB1*0102. (PubMed id 15361132)1, 2 Lv F.... Xu A. (2004)
    99. DPB1 alleles are associated with type 1 diabetes susceptibility in multiple ethnic groups. (PubMed id 15277401)1, 4 Cruz T.D....Noble J.A. (2004)
    100. Role of HLA class II alleles in susceptibility to and protection from localized cutaneous leishmaniasis. (PubMed id 15041165)1, 4 Olivo-Diaz A....Gorodezky C. (2004)
    101. Genetic polymorphism and linkage disequilibrium of the HLA-DP region in Basques from Navarre (Spain). (PubMed id 15304007)1, 4 Perez-Miranda A.M....Pena J.A. (2004)
    102. A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation. (PubMed id 14576061)1, 4 Zino E....Fleischhauer K. (2004)
    103. The association between HLA-DPB1Glu69 and chronic beryllium disease and beryllium sensitization. (PubMed id 15273960)1, 4 McCanlies E.C....Weston A. (2004)
    104. HLA class-I and HLA class-II phenotypic, gene and haplotypic frequencies in Tunisians by using molecular typing data. (PubMed id 15361135)1, 4 Ayed K....Gebuhrer L. (2004)
    105. Human leukocyte antigen class II associations with systemic sclerosis in South Africans. (PubMed id 15104683)1, 4 Tikly M....Welsh K. (2004)
    106. Strong linkage disequilibrium between HLA-B*3913 and DRB1*0807 in Brazilians. (PubMed id 15194283)1, 4 Moraes M.E....Moraes J.R. (2004)
    107. HLA-DRB1, TAP2/TAP1, and HLA-DPB1 haplotypes in Finnish juvenile idiopathic arthritis: more complexity within the MHC. (PubMed id 15343265)1, 4 Runstadler J.A....Seldin M.F. (2004)
    108. [Association of HLA-DPB1 alleles with chronic myelogenous leukemia in southern Chinese Hans] (PubMed id 12844410)1, 4 Tian H....Xu A.L. (2003)
    109. HLA-DRB1, DQB1 and DPB1 polymorphism in the Naxi ethnic group of South-western China. (PubMed id 12694588)1, 4 Fu Y....Xu A. (2003)
    110. [Association study on HLA-DP and -DQ allelic polymorphisms and nasopharyngeal carcinoma in the Han nationality in Hunan province] (PubMed id 12778461)1, 4 Zhou J.F....Yu P. (2003)
    111. High resolution sequence-based DPB1 typing identified two novel DPB1 alleles, DPB1*9401 and DPB1*9501, from a Kenyan population. (PubMed id 12890000)1, 2 Luo M.... Plummer F.A. (2003)
    112. The degree of matching at HLA-DPB1 predicts for acute graft-versus-host disease and disease relapse following haematopoietic stem cell transplantation. (PubMed id 12774051)1, 4 Shaw B.E....Madrigal J.A. (2003)
    113. Associations between patients with endometriosis and HLA class II; the analysis of HLA-DQB1 and HLA-DPB1 genotypes. (PubMed id 12721173)1, 4 Ishii K....Tanaka K. (2003)
    114. Roles of HLA-B, HLA-C and HLA-DPA1 incompatibilities in the outcome of unrelated stem-cell transplantation. (PubMed id 12956878)1, 4 Schaffer M....Olerup O. (2003)
    115. Identification of a novel DPB1 allele, DPB1*9301, by sequence-based typing in a Lahu ethnic minority of China. (PubMed id 12694578)1, 2 Liu Z.-H.... Xu A. (2003)
    116. HLA-DPB1 alleles association of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus. (PubMed id 12892399)1, 4 Sebastiani G.D....Marcolongo R. (2003)
    117. HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites. (PubMed id 14508706)1, 4 Rossman M.D....Monos D. (2003)
    118. HLA-DPB1 and chronic beryllium disease: a HuGE review. (PubMed id 12615603)1, 4 McCanlies E.C....Weston A. (2003)
    119. HLA class II antigens associated with lupus nephritis in Italian SLE patients. (PubMed id 12651073)1, 4 Marchini M....Scorza R. (2003)
    120. HLA DRB10405-DQB10401 haplotype is associated with autoimmune pancreatitis in the Japanese population. (PubMed id 11984513)1, 4 Kawa S....Kiyosawa K. (2002)
    121. The association of specific HLA class I and II alleles with type 1 diabetes among Filipinos. (PubMed id 12445315)1, 4 Bugawan T.L....Erlich H.A. (2002)
    122. Genetic susceptibility to childhood common acute lymphoblastic leukaemia is associated with polymorphic peptide-binding pocket profiles in HLA-DPB1*0201. (PubMed id 12075003)1, 4 Taylor G.M....Eden O.B. (2002)
    123. HLA and cytokine gene polymorphisms in biliary atresia. (PubMed id 12100571)1, 4 Donaldson P.T....Kelley D. (2002)
    124. The influence of patient characteristics, disease variables, and HLA alleles on the development of radiographically evident sacroiliitis in juvenile idiopathic arthritis. (PubMed id 11953976)1, 4 Flato B....Forre O. (2002)
    125. HLA class II markers and clinical heterogeneity in Swedish patients with primary biliary cirrhosis. (PubMed id 12144621)1, 4 Wassmuth R....Lindgren S. (2002)
    126. Analysis of HLA in children with gelatin allergy. (PubMed id 12144625)1, 4 Sakaguchi M....Inouye S. (2002)
    127. HLA class II sequence-based typing in normal Saudi individuals. (PubMed id 12445309)1, 4 Al-Hussein K.A....Tilanus M.G. (2002)
    128. Association of HLA-DPB1 gene with endometriosis in women of Guangdong Province in China. (PubMed id 12390706)1, 4 He Y.L....Xu A.L. (2002)
    129. Combination of HLA-A and HLA class II alleles controls the susceptibility to rheumatoid arthritis. (PubMed id 11929590)1, 4 Tsuchiya K....Sasazuki T. (2001)
    130. Modeling of HLA class II susceptibility to Type I diabetes reveals an effect associated with DPB1. (PubMed id 11668578)1, 4 Valdes A.M....Thomson G. (2001)
    131. Association of chronic lymphocytic leukemia with specific alleles of the HLA-DR4:DR53:DQ8 haplotype in German patients. (PubMed id 11291046)1, 4 Machulla H.K....Langner J. (2001)
    132. HLA class II alleles in Chinese patients with hepatocellular carcinoma. (PubMed id 11318984)1, 4 Donaldson P.T....Johnson P.J. (2001)
    133. HLA class II allele distribution in the Gypsy community of Andalusia, southern Spain. (PubMed id 11260508)1, 4 Ramal L.M....Lopez-Nevot M.A. (2001)
    134. HLA-DRB1, -DQA1, -DQB1 and DPB1 susceptibility alleles in Cameroonian type 1 diabetes patients and controls. (PubMed id 11532022)1, 4 Mbanya J.C....Mbanya D.N. (2001)
    135. Class II HLA associations with autoantibodies in scleroderma: a highly significant role for HLA-DP. (PubMed id 11393660)1, 4 Gilchrist F.C....du Bois R.M. (2001)
    136. The biological significance of HLA-DP gene variation in haematopoietic cell transplantation. (PubMed id 11298597)1, 4 Petersdorf E.W....Hansen J.A. (2001)
    137. Major histocompatibility locus genetic markers of beryllium sensitization and disease. (PubMed id 11716174)1, 4 Saltini C....Tinelli C. (2001)
    138. HLA class II polymorphism in Aka Pygmies and Bantu Congolese and a reassessment of HLA-DRB1 African diversity. (PubMed id 11782272)1, 4 Renquin J....Kaplan C. (2001)
    139. HLA alleles in relation to specific immunity to liver stage antigen-1 from plasmodium falciparum in Gabon. (PubMed id 11294566)1, 4 Migot-Nabias F....Deloron P. (2001)
    140. DPB1*8601, a previously unrecognized DPB1 variant in the Caucasoid population. (PubMed id 11556983)1, 2 Bengtsson M. (2001)
    141. Epstein-Barr Virus and HLA-DPB1-*0301 in young adult Hodgkin's disease: evidence for inherited susceptibility to Epstein-Barr Virus in cases that are EBV(+ve). (PubMed id 11401923)1, 4 Alexander F.E....Taylor G.M. (2001)
    142. Allele frequencies and haplotypic associations defined by allelic DNA typing at HLA class I and class II loci in the Japanese population. (PubMed id 11169242)1, 4 Saito S....Ota M. (2000)
    143. The nucleotide sequence of two new DP alleles, DPA1*02015 and DPB1*8401, identified in a Chinese subject. (PubMed id 10958363)1, 2 McTernan C.L.... Barnett A.H. (2000)
    144. Four new DP alleles identified in a study of 500 unrelated bone marrow donor-recipient pairs. (PubMed id 10090623)1, 2 Steiner L.L....Williams T.M. (1999)
    145. Identification of two new DPB1 alleles, DPB1*7701 and *7801, by sequence-based typing. (PubMed id 9756410)1, 2 Voorter C.... van den Berg-Loonen E. (1998)
    146. Identification of a new DPB1 allele (DPB1*7901) by sequence-based typing. (PubMed id 9756411)1, 2 Voorter C....van den Berg-Loonen E. (1998)
    147. Six new DPB1 alleles identified in a study of 1,302 unrelated bone marrow donor-recipient pairs. (PubMed id 9174146)1, 2 Noreen H....Begovich A.B. (1997)
    148. DPB1*BR: an Mhc class II DPB1 allele (DPB1*6601) of negroid origin. (PubMed id 8781129)1, 2 Schnittger L.... Meyer C.G. (1996)
    149. DPB1*5901a: a novel HLA-DPB1 allele from a Caucasian family with insulin-dependent diabetes mellitus. (PubMed id 8851734)1, 2 Noble J.A.... Erlich H.A. (1996)
    150. Three new DPB1 alleles identified in a Bantu-speaking population from central Cameroon. (PubMed id 8773318)1, 2 Zimmerman P.A.... Begovich A.B. (1996)
    151. Identification of the novel HLA-DPB1*5801 allele detected by sequenced based typing. (PubMed id 7806296)1, 2 Versluis L.F.... Dawkins R.L. (1995)
    152. Characterization of a new DPB1 allele (DPB1*5701) isolated from a Caucasian individual. (PubMed id 8525482)1, 2 Mersch G.... Rossau R. (1995)
    153. A novel HLA-DPB1 allele, DPB1*3601 (DPB1*KT). (PubMed id 7817379)1, 2 Ogawa K.... Inoko H. (1994)
    154. Direct sequencing of a novel DPB1 allele (DPB1*5101) of the heterozygote from the membrane of reverse dot blot analysis. (PubMed id 7839356)1, 2 Kaneshige T.... Uchida K. (1994)
    155. A new HLA-DPB1 allele, DPB1*SUT (DPB1*4701). (PubMed id 7912859)1, 2 Koshizaka T.... Inoko H. (1994)
    156. Seven new DPB1 alleles and their population distribution. (PubMed id 8085260)1, 2 Moonsamy P.V....Begovich A.B. (1994)
    157. Identification of a new HLA-DPB1 allele detected by PCR-RFLP and its nucleotide sequence determination by direct sequencing after PCR amplification. (PubMed id 7901923)1, 2 Mizuki N....Geng L. (1993)
    158. Family study on HLA-DPB1 polymorphism: linkage analysis with HLA- DR/DQ and two "new" alleles. (PubMed id 1358867)1, 2 Mitsunaga S.... Juji T. (1992)
    159. A new HLA-DPB1 allele from a patient with systemic lupus erythematosus. (PubMed id 1529429)1, 2 Korioth F.... Frey J. (1992)
    160. Rapid HLA-DPB typing using enzymatically amplified DNA and nonradioactive sequence-specific oligonucleotide probes. (PubMed id 2242906)1, 2 Bugawan T.L.... Erlich H.A. (1990)
    161. Sequence polymorphism of HLA-DP beta chains. (PubMed id 2714855)1, 2 Lee J.S....Yunis I. (1989)
    162. The beta-chains of DP4 molecules from different haplotypes are encoded by the same gene. (PubMed id 2838415)1, 2 Compagnone-Post P.... Trucco M. (1988)
    163. Analysis of HLA-DP allelic sequence polymorphism using the in vitro enzymatic DNA amplification of DP-alpha and DP-beta loci. (PubMed id 2460556)1, 2 Bugawan T.L.... Erlich H.A. (1988)
    164. Class II genes of the human major histocompatibility complex. Evolution of the DP region as deduced from nucleotide sequences of the four genes. (PubMed id 3036829)1, 2 Gustafsson K.... Peterson P.A. (1987)
    165. Complete nucleotide sequence of a functional HLA-DP beta gene and the region between the DP beta 1 and DP alpha 1 genes: comparison of the 5' ends of HLA class II genes. (PubMed id 2987832)1, 2 Kelly A. and Trowsdale J. (1985)
    166. DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression. (PubMed id 2998758)1, 2 Tonnelle C.... Long E.O. (1985)
    167. Structure and polymorphism of the HLA class II SB light chain genes. (PubMed id 6098459)1, 2 Kappes D.J.... Strominger J.L. (1984)
    168. Molecular organization of the HLA-SB region of the human major histocompatibility complex and evidence for two SB beta-chain genes. (PubMed id 6330724)1, 2 Gorski J.... Mach B. (1984)
    169. Genetic mapping of a human class II antigen beta-chain cDNA clone to the SB region of the HLA complex. (PubMed id 6310612)1, 2 Roux-Dosseto M.... Strominger J.L. (1983)
    170. HLA-DPB1 mismatch at position 69 is associated with high helper T lymphocyte precursor frequencies in unrelated bone marrow transplant pairs. (PubMed id 8932283)4, 9 Potolicchio I....Sorrentino R. (1996)
    171. Association of primary biliary cirrhosis with the allele HLA-DPB1*0301 in a German population. (PubMed id 7843712)4, 9 Mella J.G....Volk B.A. (1995)
    172. Evidence for discoordinate regulation of the HLA-DPB1 gene. (PubMed id 12542744)1, 9 Coiras M.T....Sanchez-Perez M. (2002)
    173. [A preliminary study on the association between HLA-DPB1 gene and pathological myopia] (PubMed id 10680551)4, 9 Zhang K....Chu R. (1997)
    174. HLA-DPB1 allelic frequency of the Lisu ethnic group in the Southwest China and evolutionary relationship of Lisu with other populations. (PubMed id 15730526)1, 9 Hu W.H....Xiao C.J. (2005)
    175. Molecular analysis of an HLA-DP mutant cell line selected for its resistance to killing by HLA-DPw2-specific T-cell clones. (PubMed id 8225437)1, 9 Arroyo J.... Sanchez-Perez M. (1994)
    176. BTNL2 allele associations with chronic beryllium disease in HLA-DPB1*Glu69-negative individuals. (PubMed id 17927685)4, 9 Sato H....Maier L.A. (2007)
    177. Celiac disease is associated with an extended HLA-DR3 haplotype which includes HLA-DPw1. (PubMed id 1971269)4, 9 Hall M.A....Ciclitira P.J. (1990)
    178. Association of increased frequencies of HLA-DPB1*05:01 with the presence of anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese rheum atoid arthritis and systemic lupus erythematosus patients. (PubMed id 23320107)1 Furukawa H....Tohma S. (2013)
    179. Genome-wide association study of aspirin-exacerbated r espiratory disease in a Korean population. (PubMed id 23180272)1 Park B.L....Park C.S. (2013)
    180. Genetic variants in HLA-DP/DQ contribute to risk of ce rvical cancer: a two-stage study in Chinese women. (PubMed id 23428460)1 Jiang J....Shen H. (2013)
    181. Multiple mismatches at the low expression HLA loci DP, DQ, and DRB3/4/5 associate with adverse outcomes in hematopoietic stem cell tra nsplantation. (PubMed id 23596045)1 Fernandez-Vina M.A....de Lima M. (2013)
    182. Host genetic factors affecting spontaneous HBsAg seroc learance in chronic hepatitis B patients. (PubMed id 23326374)1 Cheng H.R....Kao J.H. (2013)
    183. Effect of T-cell-epitope matching at HLA-DPB1 in recip ients of unrelated-donor haemopoietic-cell transplantation: a retrospective stud y. (PubMed id 22340965)1 Fleischhauer K....Petersdorf E.W. (2012)
    184. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. (PubMed id 22286218)1 Raychaudhuri S....de Bakker P.I. (2012)
    185. Strategy for identifying dendritic cell-processed CD4+ T cell epitopes from the HIV gag p24 protein. (PubMed id 22860026)1 Bozzacco L....Fenyo D. (2012)
    186. Genome-wide association study confirming association o f HLA-DP with protection against chronic hepatitis B and viral clearance in Japa nese and Korean. (PubMed id 22737229)1 Nishida N....Mizokami M. (2012)
    187. Association of HLA genes with clinical outcomes of ANC A-associated vasculitis. (PubMed id 22595829)1 Chang D.Y....Zhao M.H. (2012)
    188. HLA-DP genetic variation, proxies for early life immun e modulation and childhood acute lymphoblastic leukemia risk. (PubMed id 22923493)1 Urayama K.Y....Buffler P.A. (2012)
    189. Chronic beryllium disease, HLA-DPB1, and the DP peptid e binding groove. (PubMed id 22972925)1 Silveira L.J....Maier L.A. (2012)
    190. A novel variant marking HLA-DP expression levels predi cts recovery from hepatitis B virus infection. (PubMed id 22496224)1 Thomas R....Carrington M. (2012)
    191. Full-length HLA-DPB1 diversity in multiple alleles of individuals from Caucasian, Black, or Oriental origin. (PubMed id 22224408)1 Lauterbach N....Tilanus M.G. (2012)
    192. Classical HLA-DRB1 and DPB1 alleles account for HLA as sociations with primary biliary cirrhosis. (PubMed id 22573116)1 Invernizzi P....Seldin M.F. (2012)
    193. HIV-1 Gag-virus-like particles induce natural killer c ell immune responses via activation and maturation of dendritic cells. (PubMed id 21778700)1 Chang M.O....Takaku H. (2012)
    194. A meta-analysis of genome-wide association studies of follicular lymphoma. (PubMed id 23025665)1 Skibola C.F....Smedby K.E. (2012)
    195. HLA-DPB1*0201 is associated with susceptibility to ato pic myelitis in Japanese. (PubMed id 22884298)1 Sato S....Kira J. (2012)
    196. HLA class II DPB1 and DRB1 polymorphisms associated w ith genetic susceptibility to beryllium toxicity. (PubMed id 21186201)1 Rosenman K.D....Monos D. (2011)
    197. Associations of HLA-DP variants with hepatitis B virus infection in southern and northern Han Chinese populations: a multicenter case- control study. (PubMed id 21904616)1 Li J....Lin J. (2011)
    198. Comprehensive genotyping in two homogeneous Graves' d isease samples reveals major and novel HLA association alleles. (PubMed id 21307958)1 Chen P.L....Chang T.C. (2011)
    199. Exposure and genetics increase risk of beryllium sens itisation and chronic beryllium disease in the nuclear weapons industry. (PubMed id 21460389)1 Van Dyke M.V....Maier L.A. (2011)
    200. Characterization of 236 novel alleles at the HLA-A, - B, -C, -DRB1, -DQB1 and -DPB1 loci from China Marrow Donor Program. (PubMed id 21732917)1 Li J....Yi X. (2011)
    201. The association of HLA-DQB1, -DQA1 and -DPB1 alleles with anti- glomerular basement membrane (GBM) disease in Chinese patients. (PubMed id 21569485)1 Luo H....Zhao M.H. (2011)
    202. A genome-wide association study identifies two new ris k loci for Graves' disease. (PubMed id 21841780)1 Chu X....Song H.D. (2011)
    203. HLA-DPB1-COL11A2 and three additional xMHC loci are i ndependently associated with RA in a UK cohort. (PubMed id 21293383)1 Orozco G....Thomson W. (2011)
    204. Genome-wide association study identifies susceptibili ty loci for IgA nephropathy. (PubMed id 21399633)1 Gharavi A.G....Lifton R.P. (2011)
    205. Editorial. Nef: a notorious enigmatic factor in HIV bi ology. (PubMed id 22175768)1 Verhasselt B. (2011)
    206. Risk of chronic beryllium disease by HLA-DPB1 E69 gen otype and beryllium exposure in nuclear workers. (PubMed id 21471109)1 Van Dyke M.V....Maier L.A. (2011)
    207. Nef performance in macrophages: the master orchestrato r of viral persistence and spread. (PubMed id 22103834)1 Ghiglione Y. and Turk G. (2011)
    208. Pathway-based analysis of genetic susceptibility to ce rvical cancer in situ: HLA-DPB1 affects risk in Swedish women. (PubMed id 21716314)1 Ivansson E.L....Gyllensten U.B. (2011)
    209. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    210. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    211. Risk alleles for chronic hepatitis B are associated w ith decreased mRNA expression of HLA-DPA1 and HLA-DPB1 in normal human liver. (PubMed id 21346778)1 O'Brien T.R....Prokunina-Olsson L. (2011)
    212. Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence. (PubMed id 21922073)1 Tokarev A. and Guatelli J. (2011)
    213. Association of susceptibility to Takayasu arteritis i n Chinese Han patients with HLA-DPB1. (PubMed id 21658421)1 Lv N....Liu G. (2011)
    214. One protein to rule them all: modulation of cell surfa ce receptors and molecules by HIV Nef. (PubMed id 22103833)1 Landi A....Verhasselt B. (2011)
    215. Identification of an HLA-DPB1*0501 restricted Melan-A /MART-1 epitope recognized by CD4+ T lymphocytes: prevalence for immunotherapy in Asian populations. (PubMed id 21760531)1 Meng Z....Jiao S. (2011)
    216. [Analysis of the HLA-DPA1 and HLA-DPB1 polymorphism o f Zhejiang Han population by PCR-sequence based typing] (PubMed id 20376809)1 Dai W.J....Zhao H.C. (2010)
    217. [Association of regulatory region of HLA-DPB1 with na sopharyngeal carcinoma in southern Chinese Hans] (PubMed id 20518290)1 Wang P....Kong Y. (2010)
    218. Five HLA-DP molecules frequently expressed in the wor ldwide human population share a common HLA supertypic binding specificity. (PubMed id 20139279)1 Sidney J....Sette A. (2010)
    219. Extended LTA, TNF, LST1 and HLA gene haplotypes and t heir association with rubella vaccine-induced immunity. (PubMed id 20668555)1 Ovsyannikova I.G....Poland G.A. (2010)
    220. Lack of HLA class II antigen expression in microsatel lite unstable colorectal carcinomas is caused by mutations in HLA class II regu latory genes. (PubMed id 20013806)1 Michel S....Kloor M. (2010)
    221. Association of IL-4RA single nucleotide polymorphisms , HLA-DR and HLA-DQ in children with Alternaria-sensitive moderate-severe asthm a. (PubMed id 20298583)1 Knutsen A.P....Shah M.R. (2010)
    222. HLA Class I and II profiles in SALo Miguel Island (Azo res): genetic diversity and linkage disequilibrium. (PubMed id 20462405)1 Pacheco P.R....Mota-Vieira L. (2010)
    223. First report on HLA-DPB1 gene allelic distribution in the general Lebanese population. (PubMed id 20136549)1 Shammaa D....Mahfouz R.A. (2010)
    224. HLA-DRB1*0407 and *1304 are risk factors for sclerode rma renal crisis. (PubMed id 20981823)1 Nguyen B....Assassi S. (2010)
    225. Anthropological analysis of Koreans using HLA class I I diversity among East Asians. (PubMed id 20522202)1 Yang J.H....Oh H.B. (2010)
    226. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
    227. Role of HIV-1 Nef protein for virus replication in vit ro. (PubMed id 19770068)1 Jere A....Nomaguchi M. (2010)
    228. In a study for acne vulgaris, sequence-based HLA typing showed a novel DPB1 allele, DPB1*2402. (PubMed id 19775376)2 Witter K....Kauke T. (2009)
    229. Two sequence dimorphisms of DPB1 define the immunodom inant serologic epitopes of HLA-DP. (PubMed id 19635517)1 Cano P. and FernA!ndez-ViA+a M. (2009)
    230. Interactions of viral protein U (Vpu) with cellular fa ctors. (PubMed id 20012522)1 Guatelli J.C. (2009)
    231. Contribution of a haplotype in the HLA region to anti- cyclic citrullinated peptide antibody positivity in rheumatoid arthritis, indepe ndently of HLA-DRB1. (PubMed id 19950296)4 Okada Y....Yamamoto K. (2009)
    232. Strategies for inhibiting function of HIV-1 accessory proteins: a necessary route to AIDS therapy? (PubMed id 19149577)1 Richter S.N....Palu G. (2009)
    233. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    234. MHC class II transport at a glance. (PubMed id 19092054)2 Berger A.C. and Roche P.A. (2009)
    235. Immunoregulatory effects of HIV-1 Nef protein. (PubMed id 19449444)1 Quaranta M.G....Viora M. (2009)
    236. Exploring the diabetogenicity of the HLA-B18-DR3 CEH: independent association with T1D genetic risk close to HLA-DOA. (PubMed id 19458622)4 Santin I....Bilbao J.R. (2009)
    237. HIV-1 Nef promotes endocytosis of cell surface MHC cla ss II molecules via a constitutive pathway. (PubMed id 19620308)1 Chaudhry A....Rath S. (2009)
    238. CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract. (PubMed id 19533806)2 Beswick E.J. and Reyes V.E. (2009)
    239. HLA-DPB1 supertype-associated protection from childhood leukaemia: relationship to leukaemia karyotype and implications for prevention. (PubMed id 17622527)1 Taylor M....Hussain A. (2008)
    240. MHC class II molecules on the move for successful antigen presentation. (PubMed id 18046453)2 Rocha N. and Neefjes J. (2008)
    241. Human immunodeficiency virus type 1 Vpu protein interacts with CD74 and modulates major histocompatibility complex class II presentation. (PubMed id 17959659)1 Hussain A....Jameel S. (2008)
    242. Human immunodeficiency virus type-1 (HIV-1) Pr55gag vi rus-like particles are potent activators of human monocytes. (PubMed id 18945465)1 Speth C....Deml L. (2008)
    243. Immunogenetic factors in donors and patients that affect the outcome of hematopoietic stem cell transplantation. (PubMed id 17964196)1 Madrigal A. and Shaw B.E. (2008)
    244. Mycosis fungoides in childhood: description and study of two siblings. (PubMed id 17989893)1 Vassallo C....Borroni G. (2007)
    245. Frequency and targeted detection of HLA-DPB1 T cell epitope disparities relevant in unrelated hematopoietic stem cell transplantation. (PubMed id 17697965)1 Zino E....Fleischhauer K. (2007)
    246. Keeping the (kinase) party going: SLP-76 and ITK dance to the beat. (PubMed id 17652306)1 Qi Q. and August A. (2007)
    247. Autophagy in MHC class II presentation: sampling from within. (PubMed id 17241953)2 Menendez-Benito V. and Neefjes J. (2007)
    248. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. (PubMed id 17785583)1 Lee S.J....Anasetti C. (2007)
    249. HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1, DPB1) alleles and haplotypes in the Han from southern China. (PubMed id 17900288)1 Trachtenberg E....Hollenbach J. (2007)
    250. HLA-DPB1, -DRB1, and -DQB1 polymorphism defined in Ewenki ethnic minority of China Inner Mongolia Autonomous Region. (PubMed id 18001300)1 Su X....Gong M. (2007)
    251. Identification of a novel HLA-DPB1 allele (DPB1*1902) by haplotype-specific extraction and nucleotide sequencing. (PubMed id 17493157)1 Dapprich J....Monos D. (2007)
    252. Modelling thymic HIV-1 Nef effects. (PubMed id 16454711)1 Stove V. and Verhasselt B. (2006)
    253. Polymorphism of HLA class II genes in Miao and Yao nationalities of Southwest China. (PubMed id 16441488)1 Liu Y....Xu A. (2006)
    254. Importance of HLA-DQ and HLA-DP polymorphisms in cytokine responses to naturally processed HLA-DR-derived measles virus peptides. (PubMed id 16714073)1 Ovsyannikova I.G....Poland G.A. (2006)
    255. H pylori receptor MHC class II contributes to the dynamic gastric epithelial apoptotic response. (PubMed id 16937440)1 Bland D.A....Reyes V.E. (2006)
    256. Graft rejection after unrelated donor hematopoietic stem cell transplantation for thalassemia is associated with nonpermissive HLA-DPB1 disparity in host-versus-graft direction. (PubMed id 16317094)1 Fleischhauer K....La Nasa G. (2006)
    257. Sequencing-based analysis of the HLA-DPB1 polymorphism in Nu ethnic group of south-west China. (PubMed id 17117948)1 Hu W....Xiao C. (2006)
    258. Assembly of major histocompatibility complex class II subunits with invariant chain. (PubMed id 16242130)1 Neumann J. and Koch N. (2005)
    259. Analysis of HLA class I and class II gene polymorphisms in Japanese patients with human T-cell lymphotropic virus type 1-associated uveitis. (PubMed id 16019679)1 Kaminagayoshi T....Sakamoto T. (2005)
    260. Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. (PubMed id 16354571)1 Li L....Zhao R.Y. (2005)
    261. Human leukocyte antigen and antigen processing machinery component defects in astrocytic tumors. (PubMed id 16322289)1 Facoetti A....Ferrone S. (2005)
    262. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    263. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. (PubMed id 15489916)1 Palacios E.H. and Weiss A. (2004)
    264. HLA-DQA1 and -DQB1 alleles in Latino and African American children with diabetes mellitus. (PubMed id 15112906)1 McCarthy B.J....Nichol L. (2004)
    265. The HLA-DPB1*0301 marker might predict the requirement for leukotriene receptor antagonist in patients with aspirin-intolerant asthma. (PubMed id 15446291)1 Park H.S....Park C.S. (2004)
    266. HIV accessory proteins and surviving the host cell. (PubMed id 16091223)1 Anderson J.L. and Hope T.J. (2004)
    267. HLA association in aspirin-intolerant asthma: DPB1*0301 as a strong marker in a Korean population. (PubMed id 15007363)1 Choi J.H....Park H.S. (2004)
    268. Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors. (PubMed id 15194762)1 Kirchhoff F....Munch J. (2004)
    269. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    270. HIV/SIV escape from immune surveillance: focus on Nef. (PubMed id 15078178)1 Tolstrup M....Duch M. (2004)
    271. Identification of a novel HLA-DPB1 allele, DPB1*9701, by sequence- based typing. (PubMed id 15140044)2 Lapi S.... Scatena F. (2004)
    272. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    273. [Alleles of HLA-DQB1 and familial aggregation of type 1 diabetes] (PubMed id 12878786)1 Kubryn I....Bodalski J. (2003)
    274. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    275. HLA-DRB1*, -DQB1* in Piramalai Kallars and Yadhavas, two Dravidian-speaking castes of Tamil Nadu, South India. (PubMed id 12823769)1 Shanmugalakshmi S....Pitchappan R.M. (2003)
    276. Sequence-based typing identifies a novel HLA-DPB1 allele, DPB1*9601. (PubMed id 12890001)2 Witter K....Albert E.D. (2003)
    277. Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles. (PubMed id 12970439)1 Schindler M....Kirchhoff F. (2003)
    278. [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: 'parasites'of the endocytosis pathway] (PubMed id 12836198)1 Benichou S. and Benmerah A. (2003)
    279. Identification of a new HLA-DPB1 allele,HLA-DPB1*9001. (PubMed id 12135440)2 Bengtsson M.... Johansson U. (2002)
    280. Genetic epidemiology of juvenile idiopathic arthritis. (PubMed id 12195624)4 Forre O. and Smerdel A. (2002)
    281. HIV-1 gp120 modulates the immunological function and expression of accessory and co-stimulatory molecules of monocyte-derived dendritic cells. (PubMed id 12427289)1 Williams M.A....Spector S.A. (2002)
    282. Identification of a novel HLA-DPB1 allele, DPB1*02014, by sequence- based typing. (PubMed id 11972883)1 Curcio M.... Rizzo G. (2002)
    283. Linkage disequilibrium between HLA-DPB1 alleles and retinoid X receptor beta haplotypes. (PubMed id 12175732)1 Rajsbaum R....Awdeh Z.L. (2002)
    284. Adapters in lymphocyte signaling. (PubMed id 11827988)1 Leo A....Schraven B. (2002)
    285. HLA-DPB1 allelic frequency of the Pumi ethnic group in south-west China and evolutionary relationship of Pumi with other populations. (PubMed id 12047363)1 Liu Z.H....Xu A. (2002)
    286. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    287. HIV-1 Nef impairs MHC class II antigen presentation and surface expression. (PubMed id 11593029)1 Stumptner-Cuvelette P....Benaroch P. (2001)
    288. Presentation of antigens by MHC class II molecules: getting the most out of them. (PubMed id 11684289)2 Villadangos J.A. (2001)
    289. Three new DP alleles identified in a study of 800 unrelated bone marrow donor-recipient pairs. (PubMed id 11782281)2 Grams S.E.... Begovich A.B. (2001)
    290. Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA. (PubMed id 11118314)1 Okamoto H....Okamoto T. (2000)
    291. Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease. (PubMed id 11050177)1 Fontenot A.P....Kotzin B.L. (2000)
    292. DPB1*8501, a novel DPB1 variant in the US Black population. (PubMed id 11034567)1 Rozemuller E.H.... Tilanus M.G.J. (2000)
    293. The mechanism of phospholipase C-gamma1 regulation. (PubMed id 11048639)1 Kim M.J....Suh P.G. (2000)
    294. Efficient incorporation of HLA class II onto human immunodeficiency virus type 1 requires envelope glycoprotein packaging. (PubMed id 10729169)1 Poon D.T....Ott D.E. (2000)
    295. Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection. (PubMed id 10661406)1 Kanazawa S....Peterlin B.M. (2000)
    296. HLA-DPB1*0501-associated opticospinal multiple sclerosis: clinical, neuroimaging and immunogenetic studies. (PubMed id 10468508)4 Yamasaki K....Kira J. (1999)
    297. HLA-DP-associated susceptibility to the optico-spinal form of multiple sclerosis in the Japanese. (PubMed id 9756407)4 Ito H....Kira J. (1998)
    298. Three new DP alleles identified in sub-Saharan Africa: DPB1*7401, DPA1*02013, and DPA1*0302. (PubMed id 9694359)2 Steiner L.L.... Begovich A.B. (1998)
    299. The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway. (PubMed id 9079699)1 Ruff A.L....August J.T. (1997)
    300. Aspirin-induced asthma and HLA-DRB1 and HLA-DPB1 genotypes. (PubMed id 9179433)4 Dekker J.W....Szczeklik A. (1997)
    301. Selective association of a 22-38 kDa glycoprotein with MHC class II DP antigen on activated human lymphocytes at the plasma membrane. (PubMed id 8649448)1 Carra G....Gerosa F. (1996)
    302. Invariant chain structure and MHC class II function. (PubMed id 8598037)2 Cresswell P. (1996)
    303. Identification of a new HLA-DPB1*6501 allele in a Caucasian individual. (PubMed id 8824162)2 Versluis L.F....Tilanus M.G.J. (1996)
    304. DPB1*TF, a novel HLA class II DPB1 allele (DPB1*6701) identified in a Turkish family. (PubMed id 8896187)2 Meyer C.G.... Loeliger C.C. (1996)
    305. Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC. (PubMed id 7602119)1 Rowell J.F....Siliciano R.F. (1995)
    306. HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71). (PubMed id 7541827)1 Chirmule N....Pahwa S. (1995)
    307. HLA-DPB1 alleles in a population from north India and description of a new variant (DPB1*5601). (PubMed id 7638863)2 Rani R.... Stastny P. (1995)
    308. Novel HLA-DPB1 alleles detected in the Ethiopian population. (PubMed id 7744621)2 Versluis L.F....Giphart M.J. (1995)
    309. HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4. (PubMed id 7512597)1 Houlgatte R....Platier-Tonneau D. (1994)
    310. MHC class II DPB1*26012: a novel DPB1 sequence and its presumed origin. (PubMed id 7940502)1 Meyer C.G.... Schnittger L. (1994)
    311. HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41. (PubMed id 8084338)1 Chen Y.H....Dierich M.P. (1994)
    312. Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help. (PubMed id 8168144)1 Chirmule N....Pahwa S. (1994)
    313. A novel HLA-DPB1 allele (DPB1*4501) in a Dutch Caucasian healthy control. (PubMed id 8236237)1 de Vries N....van de Putte L.B. (1993)
    314. HLA-DPB1 alleles in a population from south China. (PubMed id 8420834)1 Falco M.... Stastny P. (1993)
    315. Novel class II HLA-DRB4 and DPB1 alleles found in the Belgian population. (PubMed id 8344726)2 Buyse I.... Cassiman J.J. (1993)
    316. A silent mutation in HLA-DPB1*0101 and its evolutionary implications. (PubMed id 8106267)1 Meyer C.G. and Schnittger L. (1993)
    317. HLA-DPB1 glutamate 69: a genetic marker of beryllium disease. (PubMed id 8105536)1 Richeldi L....Saltini C. (1993)
    318. Nucleotide sequence of a novel DPB1 allele, DPB1*4701. (PubMed id 8244783)1 Mitsunaga S.... Saji H. (1993)
    319. An analysis with sequence-specific oligonucleotide probes of the association between aspirin-induced asthma and antigens of the HLA system. (PubMed id 8335847)4 Lympany P.A....Lee T.H. (1993)
    320. HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes. (PubMed id 8376762)1 Callahan K.M....Siliciano R.F. (1993)
    321. Identification of CD4 and major histocompatibility complex functional peptide sites and their homology with oligopeptides from human immunodeficiency virus type 1 glycoprotein gp120: role in AIDS pathogenesis. (PubMed id 8356059)1 Zagury J.F....Picard O. (1993)
    322. A novel HLA-DPB1 sequence, DPB1*2301. (PubMed id 1412416)1 Eiermann T.H.... Goldmann S.F. (1992)
    323. Characterization of novel HLA-DPB1 alleles by oligotyping and nucleotide sequencing. (PubMed id 1481203)2 Hessner M.J. and Baxter-Lowe L.A. (1992)
    324. DPB1*WA4--an additional HLA class II allele identified in west Africa. (PubMed id 1412421)2 Meyer C.G.... Horstmann R.D. (1992)
    325. HLA class II nucleotide sequences, 1992. (PubMed id 1362295)1 Marsh S.G. and Bodomer J.G. (1992)
    326. Genetic diversity within the HLA class II region: ten new DPB1 alleles and their population distribution. (PubMed id 1440570)2 Moonsamy P.V.... Begovich A.B. (1992)
    327. Analysis of HLA genotypes and susceptibility to insulin-dependent diabetes mellitus: association maps telomeric to HLA-DP. (PubMed id 1502500)4 Baisch J.M. and Capra J.D. (1992)
    328. HLA-DP region gene polymorphism in primary IgA nephropathy: no association. (PubMed id 1362799)4 Rambausek M....Opelz G. (1992)
    329. Interaction of CD4 with HLA class II antigens and HIV gp120. (PubMed id 1869305)1 Piatier-Tonneau D....Auffray C. (1991)
    330. Positive correlation between oligonucleotide typing and T-cell recognition of HLA-DP molecules. (PubMed id 1713190)1 de Koster H.S.... Termijtelen A. (1991)
    331. Frequency of DPB1*0401 is significantly decreased in patients with allergic asthma in a mulatto population. (PubMed id 1774196)4 Caraballo L....Ferrara G.B. (1991)
    332. Modulation of the HLA class II antigen at a molecular level by maternal serum among cord blood cells and unrelated lymphocytes. (PubMed id 1832848)1 Vanderbeeken Y.E....Lucas A. (1991)
    333. Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules. (PubMed id 1978941)1 Bowman M.R....Burakoff S.J. (1990)
    334. HIV-gp120 can block CD4-class II MHC-mediated adhesion. (PubMed id 1967269)1 Rosenstein Y....Herrmann S.H. (1990)
    335. A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis. (PubMed id 2512583)1 Begovich A.B....Erlich H.A. (1989)
    336. Toxic shock syndrome toxin 1 binds to major histocompatibility complex class II molecules. (PubMed id 2542966)1 Scholl P....Chatila T. (1989)
    337. Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding. (PubMed id 2543930)1 Clayton L.K....Reinherz E.L. (1989)
    338. Inhibition of CD4+ T cell function by the HIV envelope protein, gp120. (PubMed id 2846691)1 Diamond D.C....Burakoff S.J. (1988)
    339. A newly characterized HLA-DP beta-chain allele. Evidence for DP beta heterogeneity within the DPw4 specificity. (PubMed id 2456351)1 Lair B.... Karr R.W. (1988)
    340. Expression patterns of MHC class II genes in rabbit tissues indicate close homology to human counterparts. (PubMed id 3474276)1 Kulaga H....Kindt T.J. (1987)
    341. Structure and evolution of the HLA class II SX beta gene. (PubMed id 3015787)1 Kappes D.J. and Strominger J.L. (1986)
    342. Isolation and allelic polymorphism of cDNA clones and genomic clones of HLA-DP heavy and light chains. (PubMed id 2878910)1 Ando A.... Tsuji K. (1986)
    343. AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications. (PubMed id 3489470)1 Andrieu J.M....Venet A. (1986)
    344. A processed pseudogene in an intron of the HLA-DP beta 1 chain gene is a member of the ribosomal protein L32 gene family. (PubMed id 3866218)1 Young J.A.T. and Trowsdale J. (1985)
    345. The genomic organisation and nucleotide sequence of the HLA-SB(DP) alpha gene. (PubMed id 2997750)1 Lawrance S.K.... Weissman S.M. (1985)
    346. Linkage map of two HLA-SB beta and two HLA-SB alpha-related genes: an intron in one of the SB beta genes contains a processed pseudogene. (PubMed id 6088068)1 Trowsdale J.... Travers P. (1984)
    347. Isolation of a cDNA clone coding for an SB beta-chain. (PubMed id 6325928)1 Gustafsson K....Rask L. (1984)
    348. Polymerase chain reaction--single-strand conformation polymorphism analysis of polymorphism in DPA1 and DPB1 genes: a simple, economical, and rapid method for histocompatibility testing. (PubMed id 1348744)9 Hoshino S....Sasazuki T. (1992)
    349. HLA-DPB1 associations differ between DRB1*03 positive anti-Jo-1 and anti-PM-Scl antibody positive idiopathic inflammatory myopathy. (PubMed id 19690132)9 Chinoy H....Cooper R.G. (2009)
    350. Possible susceptibility of the HLA-DPB1*0402 and HLA-DPB1*04 alleles to unexplained recurrent abortion: analysis by means of polymerase chain reaction-restricted fragment length polymorphism method. (PubMed id 10580605)9 Takakuwa K....Tanaka K. (1999)
    351. PCR-LIS-SSCP (Low ionic strength single-stranded conf ormation polymorphism)--a simple method for high-resolution allele typing of HL A-DRB1, -DQB1, and -DPB1. (PubMed id 8681139)9 Maruya E....Yokoyama S. (1996)
    352. Biochemical analysis of HLA-DP gene products by isoelectric focusing and comparison with cellular and molecular genetic typing results. (PubMed id 7710763)9 Rebmann V....Grosse-Wilde H. (1995)
    353. HLA-DPB1 polymorphism in Blang and Puyi ethnic groups of southwest China inferred from sequence-based typing. (PubMed id 17971047)9 Wang B....Xiao C. (2008)
    354. Polymorphism in the regulatory regions of the HLA-DPB1 gene. (PubMed id 10566595)9 Varney M.D....Tait B.D. (1999)
    355. Polymorphism, recombination, and linkage disequilibri um within the HLA class II region. (PubMed id 1727870)9 Begovich A.B....Klitz W. (1992)
    356. Molecular analysis of the role of the HLA class II genes DRB1, DQA1, DQB1, and DPB1 in susceptibility to Lyme arthritis. (PubMed id 1679052)9 Ruberti G....Fathman C.G. (1991)
    357. Beryllium sensitivity is linked to HLA-DP genotype. (PubMed id 11551429)9 Wang Z....Marrone B.L. (2001)
    358. Transmission disequilibrium analysis of HLA class II DRB1, DQA1, DQB1 and DPB1 polymorphisms in schizophrenia using family trios from a Han Chinese population. (PubMed id 11343866)9 Li T....Collier D.A. (2001)
    359. Dissection of positive regulatory elements in the ups tream region of the HLA-DPB1 gene. (PubMed id 7652737)9 Koide Y. and Yoshida T.O. (1995)
    360. HLA class II alleles in isocyanate-induced asthma. (PubMed id 8111601)9 Bignon J.S....Charron D. (1994)
    361. The relationship between human sperm fertilizing capacity and histocompatibility linked antigen (HLA) alleles gene sequences. (PubMed id 8027284)9 Chan P.J....Tredway D.R. (1994)
    362. HLA DQ and DP locus mismatches and their effect on MLC in HLA class I- and DRB1-matched unrelated patient/donor pairs waiting for allogeneic bone-marrow transplantation. (PubMed id 8128190)9 Partanen J. and Koskimies S. (1994)
    363. Analysis of HLA DP, DQ, and DR alleles in adult Italian rheumatoid arthritis patients. (PubMed id 1429034)9 Angelini G....Fanetti G. (1992)
    364. HLA-DPB1 gene polymorphism and multiple sclerosis: a large case-control study in the southwest of France. (PubMed id 1918327)9 Roth M.P....Clanet M. (1991)
    365. HLA-DRB1, -DQA1, -DQB1, -DPA1 and -DPB1 genes in Japanese multiple sclerosis patients. (PubMed id 1926126)9 Spurkland A....Vartdal F. (1991)
    366. Altered expression of immune defense genes in pilocytic astrocytomas. (PubMed id 16215461)9 Huang H....Ohgaki H. (2005)
    367. New genomic region for Wegener's granulomatosis as revealed by an extended association screen with 202 apoptosis-related genes. (PubMed id 14968360)9 Jagiello P....Epplen J.T. (2004)
    368. A new epitope-based HLA-DPB matching approach for cadaver kidney retransplants. (PubMed id 12792509)9 Laux G....Mytilineos J. (2003)
    369. HLA class II DRB1, DQB1, DPB1 polymorphism and cardiomyopathy due to Trypanosoma cruzi chronic infection. (PubMed id 10689123)9 Colorado I.A....Layrisse Z. (2000)
    370. Differential susceptibilities to chronic beryllium disease contributed by different Glu69 HLA-DPB1 and -DPA1 alleles. (PubMed id 10415070)9 Wang Z....Marrone B.L. (1999)

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    Entrez Gene: 3115 HGNC: 4940 AceView: HLA-DPB1 Ensembl:ENSG00000223865 euGenes: HUgn3115
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