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HLA-DPB1 Gene

protein-coding   GIFtS: 62
GCID: GC06P033043

Major Histocompatibility Complex, Class II, DP Beta 1


(Previous symbol: HLA-DP1B)
  See HLA-DPB1-related diseases
at
MalaCards
 

Aliases
for HLA-DPB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Major Histocompatibility Complex, Class II, DP Beta 11 2     HLA DP14-Beta Chain2
HLA-DP1B1 2 3     HLA-DP Histocompatibility Type, Beta-1 Subunit2
HLA Class II Histocompatibility Antigen, DP(W4) Beta Chain2 3     Major Histocompatibility Complex Class II Antigen Beta Chain2
MHC Class II Antigen DPB12 3     MHC Class II Antigen Beta Chain2
DPB12     MHC Class II Antigen DP Beta 1 Chain2
HLA-DP2     MHC Class II Antigen DPbeta12
HLA-DPB2     MHC Class II HLA-DP-Beta-12
Beta1 Domain MHC Class II HLA DPB2     MHC Class II HLA-DRB12
Class II HLA Beta Chain2     MHC HLA DPB12
HLA Class II Histocompatibility Antigen, DP Beta 1 Chain2     

External Ids:    HGNC: 49401   Entrez Gene: 31152   Ensembl: ENSG000002238657   OMIM: 1428585   UniProtKB: P044403   

Export aliases for HLA-DPB1 gene to outside databases

Previous GC identifers: GC06P033046 GC06P033090 GC06P033151 GC06P032786


Summaries
for HLA-DPB1 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HLA-DPB1 Gene:
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of
an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune
system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen
presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa
and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular
domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule
both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities,
resulting in up to 4 different molecules. (provided by RefSeq, Jul 2008)

GeneCards Summary for HLA-DPB1 Gene:
HLA-DPB1 (major histocompatibility complex, class II, DP beta 1) is a protein-coding gene. Diseases associated with HLA-DPB1 include beryllium disease, chronic, and chronic berylliosis. An important paralog of this gene is HLA-DRB5.

UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440
Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
(class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the
regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
efficient peptide loading

Gene Wiki entry for HLA-DPB1 Gene


Genomic Views
for HLA-DPB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NT_167244.2  NT_167245.2  NT_167246.2  NT_167247.2  NT_167248.2  NT_167249.2  
NC_018917.2  NT_113891.3  
Regulatory elements:
   Regulatory transcription factor binding sites in the HLA-DPB1 gene promoter:
         GR   Pbx1a   p300   FOXD3   CUTL1   MIF-1   Cdc5   STAT3   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HLA-DPB1 promoter sequence
   Search Chromatin IP Primers for HLA-DPB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-DPB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

HLA-DPB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-DPB1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P033043:  view genomic region     (about GC identifiers)

Start:
 33,043,703 bp from pter      End:
 33,057,473 bp from pter
Size:
 13,771 bases      Orientation:
 plus strand

Selected alternative locations (see all 7):
Chr6+,NT_167244 4,330,504-4,344,264      Chr6+,NT_167247 4,380,558-4,394,318      Chr6+,NT_167249 4,524,207-4,537,977     
Chr6+,NT_167248 4,276,154-4,289,926      Chr6+,NT_167246 4,501,243-4,515,019      Chr6+,NT_167245 4,325,042-4,338,804     

Proteins
for HLA-DPB1 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section
UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen, DP beta 1 chain precursor  
Size: 258 amino acids; 29159 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Sequence caution: Sequence=AAQ12564.1; Type=Frameshift; Positions=39;
1 PDB 3D structure from and Proteopedia for HLA-DPB1:
3LQZ (3D)    
Secondary accessions: A0PFJ7 A5I886 A8YPB3 B5U8B4 B7VF80 B7VF87 B8ZX68 B8ZYT0 B9W5S8 B9W6F7
B9W6F9 C0MPP5 C0MPQ2 C0MPQ3 C0MPQ5 C0MPQ6 C0MPQ7 C4R9J5 C5IZL1 O00259 O19698 O19700 O19702
O19749 O46884 O77952 O98215 O98216 O98217 O98218 O98219 O98222 O98223 P01916 P04232 P13763
P79493 P79608 Q0P0L4 Q0ZFN3 Q14279 Q27S71 Q29682 Q29684 Q29698 Q29714 Q29775 Q29776 Q29778
Q29779 Q29781 Q29827 Q29828 Q29879 Q29880 Q29898 Q29977 Q2MGW3 Q30015 Q30031 Q30032 Q30033
Q30034 Q30050 Q30051 Q30052 Q30053 Q30054 Q30055 Q30174 Q4GY31 Q4JHD8 Q5ENE0 Q5ENE1 Q5ENW3
Q5EP46 Q5EP47 Q5EP49 Q5EP51 Q5EP52 Q5EP53 Q5EP56 Q5I4H8 Q5I4H9 Q5ISH4 Q5ISH5 Q5SQ73 Q5STP2
Q5YLA6 Q6IVX1 Q6LBX2 Q6LBX3 Q6LBX4 Q6LBX5 Q6LBX6 Q6LBX7 Q6PWX6 Q6TAS4 Q714U1 Q714U2 Q7YQ10
Q860Z7 Q8HWL7 Q8HWT5 Q8SNC4 Q95HC1 Q95IT7 Q95IT8 Q9BD13 Q9GIM2 Q9GIM4 Q9GIX6 Q9GJ41 Q9MY67
Q9TNT7 Q9TQE2 Q9XS11 Q9XS12

Explore the universe of human proteins at neXtProt for HLA-DPB1: NX_P04440

Explore proteomics data for HLA-DPB1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn48
  • Modification sites at PhosphoSitePlus

    • See HLA-DPB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002112.3  
    ENSEMBL proteins: 
     ENSP00000408146   ENSP00000412654   ENSP00000399832   ENSP00000439674  
    Reactome Protein details: P04440

    HLA-DPB1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HLA-DPB1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HLA-DPB1
    GenScript Custom Purified and Recombinant Proteins Services for HLA-DPB1
    Novus Biologicals HLA-DPB1 Proteins
    Novus Biologicals HLA-DPB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

         		 Search eBioscience for Proteins for HLA-DPB1 

         		 Search GeneTex for Proteins for HLA-DPB1 

         		antibodies-online proteins for HLA-DPB1 (5 products) 

         		antibodies-online peptides for HLA-DPB1

    HLA-DPB1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HLA-DPB1
    Novus Biologicals HLA-DPB1 Antibodies
    Abcam antibodies for HLA-DPB1 (P28068, Q30631, P04440)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for HLA-DPB1
    antibodies-online antibodies for HLA-DPB1 (45 products) 

    HLA-DPB1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for HLA-DPB1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for HLA-DPB1 
    antibodies-online kits for HLA-DPB1 

    Domains /
    Families
    for HLA-DPB1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    		 HGNC Gene Families:
    HLA: Histocompatibility complex
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    Selected InterPro protein domains (see all 7):
     IPR011162 MHC_I/II-like_Ag-recog
     IPR000353 MHC_II_b_N
     IPR013783 Ig-like_fold
     IPR014745 MHC_II_a/b_N
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry P04440

    ProtoNet protein and cluster: P04440

    3 Blocks protein domains:
    IPB000353 Class II histocompatibility antigen
    IPB001003 MHC Class II alpha chain
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: DPB1_HUMAN, P04440
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Find genes that share domains with HLA-DPB1           About GenesLikeMe


    Function
    for HLA-DPB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPB1_HUMAN, P04440
    Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
    and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
    peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
    of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
    hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
    via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
    As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
    contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
    endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
    MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
    epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
    tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
    an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
    of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
    degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
    (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
    the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
    affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
    membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
    Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the
    regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
    efficient peptide loading

         Genatlas biochemistry entry for HLA-DPB1:
    HLA-DP,beta chain

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with HLA-DPB1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HLA-DPB1

    miRNA
    Products:            		Block miRNA regulation of human, mouse, rat HLA-DPB1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HLA-DPB1:
    hsa-miR-767-3p hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmid: HLA-DPB1 3' UTR sequence
    Inhib. RNA
    Products:            		OriGene RNAi products in human, mouse, rat for HLA-DPB1
    Predesigned siRNA for gene silencing in human, mouse, rat HLA-DPB1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HLA-DPB1

    Clone
    Products:             		 OriGene clones in human, mouse for HLA-DPB1 (see all 8)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLA-DPB1 (NM_002121)
    Sino Biological Human cDNA Clone for HLA-DPB1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-DPB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DPB1

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HLA-DPB1
    Browse ESI BIO Cell Lines and PureStem Progenitors for HLA-DPB1 
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DPB1


    Localization
    for HLA-DPB1 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section
    Subcellular locations from UniProtKB/Swiss-Prot
    DPB1_HUMAN, P04440: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic
    pathway until it reaches the cell membrane for antigen presentation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome5
    lysosome5
    plasma membrane5
    vacuole5
    golgi apparatus4
    extracellular2
    nucleus1

    Gene Ontology (GO): 13 cellular component terms (see first 5):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005765lysosomal membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane IEA--
    GO:0012507ER to Golgi transport vesicle membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----
    GO:0030658transport vesicle membrane TAS--
    GO:0030666endocytic vesicle membrane TAS--
    GO:0030669clathrin-coated endocytic vesicle membrane TAS--
    GO:0032588trans-Golgi network membrane TAS--
    GO:0042613MHC class II protein complex IEA--
    GO:0071556integral component of lumenal side of endoplasmic reticulum membrane TAS--

    Find genes that share ontologies with HLA-DPB1           About GenesLikeMe


    Pathways & Interactions
    for HLA-DPB1 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section





    SuperPaths for HLA-DPB1 About   (see all 20)  
    See pathways by source

    		      Powered
    by    		     
    SuperPathSelected contained pathways About (see all per SuperPath)
    1Allograft rejection
    		Allograft rejection0.86
    		Asthma0.46
    		Allograft Rejection0.86
    		Intestinal immune network for IgA production0.41
    		Type I diabetes mellitus0.69
    		Viral myocarditis0.40
    		Graft-versus-host disease0.65
    		Antigen processing and presentation0.36
    2Translocation of ZAP-70 to Immunological synapse
    		Translocation of ZAP-70 to Immunological synapse0.83
    		PD-1 signaling0.72
    		Phosphorylation of CD3 and TCR zeta chains0.83
    		Generation of second messenger molecules0.62
    3Interferon Signaling
    		Interferon Signaling0.59
    		Interferon gamma signaling0.41
    		Cytokine Signaling in Immune system0.59
    4Immune response NFAT in immune response
    		Immune response NFAT in immune response0.56
    		Immune response T cell receptor signaling pathway0.52
    		Immune response ICOS pathway in T-helper cell0.56
    5Immune response Antigen presentation by MHC class II
    		Immune response Antigen presentation by MHC class II0.52
    		Immune response IL-22 signaling pathway0.36
    		G-protein signaling N-RAS regulation pathway0.52


    Find genes that share SuperPaths with HLA-DPB1           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for HLA-DPB1 (see all 6)
        Immune response Antigen presentation by MHC class II
    Immune response ICOS pathway in T-helper cell
    Immune response T cell receptor signaling pathway
    Immune response IL-22 signaling pathway
    G-protein signaling N-RAS regulation pathway

    1 BioSystems Pathway for HLA-DPB1
        Allograft Rejection

    1 Sino Biological Pathway for HLA-DPB1
        NF-kB (NFkB) Pathway

    Selected Reactome Pathways for HLA-DPB1 (see all 7)
        Translocation of ZAP-70 to Immunological synapse
    Interferon gamma signaling
    Downstream TCR signaling
    PD-1 signaling
    MHC class II antigen presentation


    Selected Kegg Pathways  (Kegg details for HLA-DPB1) (see all 21):
        Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Intestinal immune network for IgA production
    Type I diabetes mellitus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HLA-DPB1
    Interactions:

        GeneGlobe Interaction Network for HLA-DPB1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for HLA-DPB1 (P044402, 3 ENSP000004081464) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ROBO2Q9HCK42, 3MINT-8258142 I2D: score=2 
    RTN4Q9NQC32, 3MINT-8258153 I2D: score=2 
    HLA-DPA1P200363, ENSP000003935664I2D: score=1 STRING: ENSP00000393566
    ENSG00000168384P200363I2D: score=1 
    ENSG00000206291P200363I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002504antigen processing and presentation of peptide or polysaccharide antigen via MHC class II ----
    GO:0006955immune response ----
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0019882antigen processing and presentation ----
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    Find genes that share ontologies with HLA-DPB1           About GenesLikeMe



    Drugs & Compounds
    for HLA-DPB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HLA-DPB1 (DPB1)

    4 Novoseek inferred chemical compound relationships for HLA-DPB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpa 1 96.1 37 11556979 (4), 1348744 (3), 7710763 (2), 8225437 (2) (see all 15)
    beryllium 66.1 7 10415070 (2), 11551429 (2), 10860658 (1), 14662898 (1)
    oligonucleotide 30.5 6 8436419 (1), 8863870 (1), 10566595 (1), 1971269 (1) (see all 5)
    glutamate 0 1 11551429 (1)



    Find genes that share compounds with HLA-DPB1           About GenesLikeMe



    Transcripts
    for HLA-DPB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section
    REFSEQ mRNAs for HLA-DPB1 gene (15 alternative transcripts): 
    NM_002121.5  XM_006715077.1  XM_006715078.1  XM_006725039.1  XM_006725040.1  XM_006725698.1  XM_006725699.1  XM_006725816.1  
    XM_006725817.1  XM_006725907.1  XM_006725908.1  XM_006725997.1  XM_006725998.1  XM_006726087.1  XM_006726088.1  

    Unigene Cluster for HLA-DPB1:

    Major histocompatibility complex, class II, DP beta 1
    Hs.485130  [show with all ESTs]
    Unigene Representative Sequence: NM_002121
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418931(uc003ocu.2 uc011dqo.2) ENST00000469120 ENST00000471184
    ENST00000488575 ENST00000498038 ENST00000428835 ENST00000416804(uc011dqq.1)
    ENST00000478189 ENST00000535465(uc011dqn.2)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate HLA-DPB1:
    hsa-miR-767-3p hsa-miR-9*
    SwitchGear 3'UTR luciferase reporter plasmid: HLA-DPB1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HLA-DPB1
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HLA-DPB1 (NM_002121)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat HLA-DPB1
      QuantiFast Probe-based Assays in human, mouse, rat HLA-DPB1

    Additional mRNA sequence: 

    AB208978.1 AK291986.1 AK301322.1 AK303153.1 AK313305.1 AY656678.1 AY656679.1 AY656680.1 
    AY804132.1 AY804133.1 AY804134.1 AY804135.1 AY804136.1 AY804137.1 AY804138.1 AY804139.1 
    AY804140.1 AY804141.1 AY804142.1 AY804143.1 AY831401.1 AY831402.1 AY831403.1 AY831404.1 
    BC007963.2 BC013184.1 BC015000.1 BT019780.1 DQ284441.1 FR775797.1 FR775798.1 GQ891549.1 
    HE603611.1 HE603612.1 HE614584.1 HE614585.1 HE614586.1 HE614587.1 HE614588.1 HE614589.1 
    HE614590.1 HE614591.1 J03041.1 K00409.1 K01615.1 L29173.1 M21886.1 M28200.1 
    M28201.1 M28202.1 M57466.1 M83664.1 S66883.1 S79786.1 X00532.1 X01426.1 
    X03067.1 

    Selected DOTS entries (see all 35):

    DT.100826689  DT.91878430  DT.91791833  DT.452653  DT.100826691  DT.95269923  DT.40127111  DT.75122389 
    DT.121402840  DT.121402869  DT.104576  DT.300839  DT.97800984  DT.101961746  DT.121402689  DT.86858814 
    DT.91661820  DT.91761305  DT.95338993  DT.100044867  DT.121402700  DT.121402836  DT.121402845  DT.91720260 

    Selected AceView cDNA sequences (see all 599):

    CA439616 AA778424 W20380 AA293564 AA486532 BQ065862 BC017967 AA361875 
    BF724819 BQ066305 BQ007765 CA309047 AA507462 BM665426 BX279593 AI656151 
    BI062287 AA348191 NM_002121 BG686251 BU175417 AI214298 AW610196 CR619088 

    GeneLoc Exon Structure


    Expression
    for HLA-DPB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HLA-DPB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCCTTCTT
    HLA-DPB1 Expression
    About this image


    HLA-DPB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Blood (Cardiovascular System)
             T Helper Cells Thymus
     
     Tonsil (Hematopoietic System)
     
     Spleen (Hematopoietic System)
    HLA-DPB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    HLA-DPB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485130
        Custom PCR Arrays for HLA-DPB1
    Primer
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    In Situ
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    Orthologs
    for HLA-DPB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-DPB1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    dog
    (Canis familiaris)    		 Mammalia HLA-DPB16
    		 major histocompatibility complex, class II, DP bet...
    		 50(a)
    		 1 ↔ 1
    		 12(2604546-2607784)
    chicken
    (Gallus gallus)    		 Aves BLB31 Major histocompatibility complex class II beta chain more 65.72(n)
    54.03(a)    		   425256  XM_423039.4  XP_423039.4 


    ENSEMBL Gene Tree for HLA-DPB1 (if available)
    TreeFam Gene Tree for HLA-DPB1 (if available)

    Paralogs
    for HLA-DPB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for HLA-DPB1 gene
    HLA-DRB52  HLA-DQA12  HLA-DPA12  HLA-DQB12  HLA-DRA2  HLA-DRB12  HLA-DOB2  HLA-DMA2  
    HLA-DQB22  HLA-DOA2  ENSG000002489932  HLA-DMB2  HLA-DQA22  
    Selected SIMAP similar genes for HLA-DPB1 using alignment to 265 protein entries:     DPB1_HUMAN (see all proteins) (see all similar genes):
    HLA-SB beta    HLA-DPB    HLA-DP    DPB1    MHC DPB1    HLA-DB1
    MHC-DPB1*6001    HLA-D8.2V    HLA-DRB13    HLA-DRB1*1327    HLA-DRB4*0102    HLA-DRB14
    HLA-DRB1*0801    HLQ-DQB1    HLA-DRB1*11    HLA-DRB1*1125    HLA-DRBI*1303    HLA-DRB1*1605

    Find genes that share paralogs with HLA-DPB1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for HLA-DPB1
    PGOHUM00000260171 PGOHUM00000260853


    Genomic Variants
    for HLA-DPB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section


    Polymorphic Variants from UniProtKB/Swiss-Prot
    DPB1_HUMAN, P04440: The following alleles of HLA-DPB1 are known: DPB1*01:01, DPB1*01:02, DPB1*02:01, DPB1*02:02,
    DPB1*02:03, DPB1*03:01, DPB1*03:02, DPB1*04:01, DPB1*04:02, DPB1*04:03, DPB1*05:01, DPB1*05:02, DPB1*06:01,
    DPB1*06:02, DPB1*08:01, DPB1*08:02, DPB1*09:01, DPB1*09:02, DPB1*10:01, DPB1*10:02, DPB1*11:01, DPB1*11:02,
    DPB1*13:01, DPB1*13:02, DPB1*14:01, DPB1*14:02, DPB1*15:01, DPB1*15:02, DPB1*16:01, DPB1*16:02, DPB1*17:01,
    DPB1*17:02, DPB1*18:01, DPB1*18:02, DPB1*19:01, DPB1*19:02, DPB1*20:01, DPB1*20:02, DPB1*21:01, DPB1*21:02,
    DPB1*22:01, DPB1*22:02, DPB1*23:01, DPB1*24:01, DPB1*24:02, DPB1*25:01, DPB1*25:02, DPB1*26:01, DPB1*26:02,
    DPB1*27:01, DPB1*28:01, DPB1*29:01, DPB1*30:01, DPB1*31:01, DPB1*32:01, DPB1*33:01, DPB1*34:01, DPB1*35:01,
    DPB1*36:01, DPB1*37:01, DPB1*38:01, DPB1*39:01, DPB1*40:01, DPB1*41:01, DPB1*44:01, DPB1*45:01, DPB1*46:01,
    DPB1*47:01, DPB1*48:01, DPB1*49:01, DPB1*50:01, DPB1*51:01, DPB1*52:01, DPB1*53:01, DPB1*54:01, DPB1*55:01,
    DPB1*56:01, DPB1*57:01, DPB1*58:01, DPB1*59:01, DPB1*60:01, DPB1*62:01, DPB1*63:01, DPB1*65:01, DPB1*66:01,
    DPB1*67:01, DPB1*68:01, DPB1*69:01, DPB1*70:01, DPB1*71:01, DPB1*72:01, DPB1*73:01, DPB1*74:01, DPB1*75:01,
    DPB1*76:01, DPB1*77:01, DPB1*78:01, DPB1*79:01, DPB1*80:01, DPB1*81:01, DPB1*82:01, DPB1*83:01, DPB1*84:01,
    DPB1*85:01, DPB1*86:01, DPB1*87:01, DPB1*88:01, DPB1*89:01, DPB1*90:01, DPB1*91:01, DPB1*92:01, DPB1*93:01,
    DPB1*94:01, DPB1*95:01, DPB1*96:01, DPB1*97:01, DPB1*98:01 and DPB1*99:01. The sequence shown is that of
    DPB1*04:01


    Selected SNPs for HLA-DPB1 (see all 493)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs10421401,2,,4
    		C,Fother132964610(+) AGGAGA/C/G/T 
                AGCGG     		2 K E mis110MN NA WA CSA EA EU 6274
    rs1415302331,2
    		C--33048688(+) GGGCG-/AGGCCC 2 G EA fra10--------
    rs3757949251,2
    		C--33050526(+) ATGTC-/TCACCC 1 -- int10--------
    rs1907550351,2
    		--33050561(+) GTTTTC/TTGGGC 1 -- int10--------
    rs31289601,2
    		C,F,H--33050654(+) TATCAA/GGCCTT 1 -- int113Minor allele frequency- G:0.47NS EA WA NA CSA 781
    rs30976731,2
    		C,F,H--33050671(+) AGCGCA/CCCCTG 1 -- int110Minor allele frequency- C:0.42NS WA NA CSA EA 481
    rs30976741,2
    		C,F,H--33050683(+) AGGTCA/C/GCTGAT 1 -- int113NS EA WA NA CSA 749
    rs31289611,2
    		C,F,O,H--33050742(+) CTCTCA/GTGGAA 1 -- int113Minor allele frequency- G:0.47NS EA WA NA CSA 771
    rs1150218821,2
    		F--33050796(+) TTCATG/AGTTCC 1 -- int11Minor allele frequency- A:0.01NA 120
    rs92773921,2
    		C,F--33050829(+) TTGTAC/GGTAAT 1 -- int112Minor allele frequency- G:0.49NA WA CSA EA 505

    HapMap Linkage Disequilibrium report for HLA-DPB1 (33043703 - 33057473 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HLA-DPB1 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731879CNV Deletion23290073
    dgv1047e201CNV Deletion23290073
    esv22467CNV Loss19812545
    dgv6828n71CNV Loss21882294
    dgv1042n67CNV Loss20364138
    nsv823656CNV Loss20364138
    nsv516221CNV Loss19592680
    dgv1041n67CNV Loss20364138
    nsv885759CNV Loss21882294
    nsv823645CNV Loss20364138

    Human Gene Mutation Database (HGMD): HLA-DPB1
    Locus Specific Mutation Databases (LSDB): HLA-DPB1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HLA-DPB1
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    Disorders / Diseases
    for HLA-DPB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    		 OMIM gene information: 142858    OMIM disorders: --

    8 diseases for HLA-DPB1:    
    About MalaCards
    beryllium disease, chronic    chronic berylliosis    wegener's granulomatosis    myelitis
    neonatal lupus erythematosus    rubella    chronic thromboembolic pulmonary hypertension    rheumatoid arthritis


    Find genes that share disorders with HLA-DPB1           About GenesLikeMe

    10 Novoseek inferred disease relationships for HLA-DPB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    beryllium disease chronic 77.6 3 10415070 (1), 10860658 (1), 14662898 (1)
    genetic susceptibility 52.7 6 11975985 (1), 17060025 (1), 1980918 (1), 7843712 (1) (see all 5)
    arthritis juvenile rheumatoid 40.5 1 8436419 (1)
    diabetes mellitus insulin-dependent 32.3 3 11592043 (3)
    myasthenia gravis 18.1 2 8357200 (1), 7749041 (1)
    graft-versus-host disease 13.6 1 8932283 (1)
    systemic disease 9.97 1 10616003 (1)
    lupus erythematosus systemic 7.62 1 8456439 (1)
    multiple sclerosis 3.56 3 1918327 (2), 1926126 (1)
    rheumatoid arthritis 0 2 1429034 (1), 1822107 (1)

    Genetic Association Database (GAD): HLA-DPB1
    Human Genome Epidemiology (HuGE) Navigator: HLA-DPB1 (168 documents)

    Export disorders for HLA-DPB1 gene to outside databases

    Publications
    for HLA-DPB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section


    PubMed articles for HLA-DPB1 gene, integrated from 10 sources (see all 421):
    (articles sorted by number of sources associating them with HLA-DPB1)

    1. Extended HLA-DPB1 polymorphism: an RNA approach for HLA-DPB1 typing. (PubMed id 16189666)1, 2, 9 Reinders J.... Tilanus M.G.J. (Immunogenetics 2005)
    2. HLA-DPA1 and DPB1 polymorphism in four Pacific Islands populations determined by sequencing based typing. (PubMed id 11556979)1, 4, 9 Velickovic Z.M. and Carter J.M. (Tissue Antigens 2001)
    3. Polymorphism of human leukocyte antigen-DRB1, -DQB1, and -DPB1 genes of Shandong Han population in China. (PubMed id 15982255)1, 4, 9 Zhou L....Xu A. (Tissue Antigens 2005)
    4. Molecular analyses of HLA-DRB1, -DPB1, and -DQB1 in Jing ethnic minority of Southwest China. (PubMed id 12878363)1, 4, 9 Lin J.H....Xu A.L. (Hum. Immunol. 2003)
    5. Polymorphism of HLA-DRB1, -DQB1 and -DPB1 genes in Bai ethnic group in southwestern China. (PubMed id 18778327)1, 4, 9 Hu W....Xiao C. (Tissue Antigens 2008)
    6. [Sequencing-based typing of HLA-DPB1 and DQB1 exon 2 in patients with type 1 diabetes mellitus]. (PubMed id 11592043)1, 4, 9 Zhang S....Jiang Z. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2001)
    7. Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controls. (PubMed id 18486765)1, 4, 9 Noble J.A....Erlich H.A. (Hum. Immunol. 2008)
    8. Association of HLA class II DRB1, DPA1 and DPB1 polymorphism with genetic susceptibility to idiopathic dilated cardiomyopathy in Chinese Han nationality. (PubMed id 17060025)1, 4, 9 Liu W....Gan R.T. (Autoimmunity 2006)
    9. Analysis of the role of DPB1-encoded amino acids in the genetic predisposition to type I diabetes mellitus. (PubMed id 11975985)1, 4, 9 Rayner M.L....Barnett A.H. (Hum. Immunol. 2002)
    10. Two new HLA DPB1 alleles identified by sequence-based typing: DPB1*8201 and DPB1*8301. (PubMed id 11169249)1, 2, 9 Voorter C.... van den Berg-Loonen E. (Tissue Antigens 2000)

    External Searches for HLA-DPB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HLA-DPB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3115 HGNC: 4940 AceView: HLA-DPB1 Ensembl:ENSG00000223865 euGenes: HUgn3115
    ECgene: HLA-DPB1 Kegg: 3115 H-InvDB: HLA-DPB1

    Other Databases showing HLA-DPB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HLA-DPB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HLA-DPB1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HLA-DPB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HLA-DPB1 gene:
    Search GeneIP for patents involving HLA-DPB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section


     
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     Browse ESI BIO Cell Lines and PureStem Progenitors for HLA-DPB1
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     Search Addgene for plasmids for HLA-DPB1
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     antibodies-online antibodies for HLA-DPB1 (45 products)
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      Search GeneTex for proteins for HLA-DPB1
           
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