HLA-DPB1 Gene(Protein Coding)

• HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]

HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1) is a Protein Coding gene. Diseases associated with HLA-DPB1 include Chronic Beryllium Disease and Wegener Granulomatosis. Among its related pathways are HTLV-I infection and TNF Signaling (sino). GO annotations related to this gene include peptide antigen binding. An important paralog of this gene is HLA-DMA.

• Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-DPB1 Gene

Regulatory Elements for HLA-DPB1 Gene

Genomic Location for HLA-DPB1 Gene

Genomic View for HLA-DPB1 Gene

Genes around HLA-DPB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

• 6p21.32 by Ensembl
• 6p21.3 by Entrez Gene
• 6p21.3 by HGNC

HLA-DPB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

RefSeq DNA sequence for HLA-DPB1 Gene

Protein Expression for HLA-DPB1 Gene

Post-translational modifications for HLA-DPB1 Gene

Other Protein References for HLA-DPB1 Gene

No data available for DME Specific Peptides for HLA-DPB1 Gene

Gene Families for HLA-DPB1 Gene

Protein Domains for HLA-DPB1 Gene

Molecular function for HLA-DPB1 Gene

Phenotypes for HLA-DPB1 Gene

Human Phenotype Ontology for HLA-DPB1 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HLA-DPB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-DPB1 Gene

Pathways by source for HLA-DPB1 Gene

Interacting Proteins for HLA-DPB1 Gene

Selected Interacting proteins: P04440-DPB1_HUMAN ENSP00000408146 for HLA-DPB1 Gene via MINT STRING I2D

Symbol	External ID(s)	Details
ROBO2	Q9HCK4 19 21 ENSP00000417335 20	MINT-8258142 STRING: ENSP00000417335 I2D: score=2
RTN4	Q9NQC3 19 21 ENSP00000337838 20	MINT-8258153 STRING: ENSP00000337838 I2D: score=2
CD74	ENSP00000009530 20 P04233 21	STRING: ENSP00000009530 I2D: score=1
HLA-DPA1	ENSP00000393566 20 P20036 21	STRING: ENSP00000393566 I2D: score=1
COPB1	ENSP00000249923 20	STRING: ENSP00000249923

No data available for SIGNOR curated interactions for HLA-DPB1 Gene

mRNA/cDNA for HLA-DPB1 Gene

Unigene Clusters for HLA-DPB1 Gene

Relevant External Links for HLA-DPB1 Gene

SOURCE GeneReport for Unigene cluster for HLA-DPB1 Gene Hs.485130

No data available for mRNA Expression by UniProt/SwissProt for HLA-DPB1 Gene

This gene was present in the common ancestor of chordates.

Evolution for HLA-DPB1 Gene

Paralogs for HLA-DPB1 Gene

Pseudogenes.org Pseudogenes for HLA-DPB1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DPB1 Gene

Relevant External Links for HLA-DPB1 Gene

Relevant External Links for HLA-DPB1

No data available for UniProtKB/Swiss-Prot and Genatlas for HLA-DPB1 Gene