Aliases for HLA-DPB1 Gene
Aliases for HLA-DPB1 Gene
External Ids for HLA-DPB1 Gene
- HGNC: 4940
- Entrez Gene: 3115
- Ensembl: ENSG00000223865
- OMIM: 142858
- UniProtKB: P04440
Previous HGNC Symbols for HLA-DPB1 Gene
- HLA-DP1B
Previous GeneCards Identifiers for HLA-DPB1 Gene
- GC06P033046
- GC06P033090
- GC06P033151
- GC06P032786
Summaries for HLA-DPB1 Gene
-
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
GeneCards Summary for HLA-DPB1 Gene
HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1) is a Protein Coding gene. Diseases associated with HLA-DPB1 include Chronic Beryllium Disease and Wegener Granulomatosis. Among its related pathways are Allograft rejection and Toxoplasmosis. GO annotations related to this gene include peptide antigen binding. An important paralog of this gene is HLA-DRB1.
UniProtKB/Swiss-Prot for HLA-DPB1 Gene
-
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-DPB1 Gene
Genomics for HLA-DPB1 Gene
Regulatory Elements for HLA-DPB1 Gene
Enhancers for HLA-DPB1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HLA-DPB1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HLA-DPB1 Gene
- Chromosome:
- 6
- Start:
- 33,075,926 bp from pter
- End:
- 33,089,696 bp from pter
- Size:
- 13,771 bases
- Orientation:
- Plus strand
Genomic View for HLA-DPB1 Gene
Genes around HLA-DPB1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.32 by Ensembl
- 6p21.32 by Entrez Gene
- 6p21.32 by HGNC
HLA-DPB1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HLA-DPB1 Gene
Proteins for HLA-DPB1 Gene
-
Protein details for HLA-DPB1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P04440-DPB1_HUMAN
- Recommended name:
- HLA class II histocompatibility antigen, DP beta 1 chain
- Protein Accession:
- P04440
- A0PFJ7
- A5I886
- A8YPB3
- B5U8B4
- B7VF80
- B7VF87
- B8ZX68
- B8ZYT0
- B9W5S8
- B9W6F7
- B9W6F9
- C0MPP5
- C0MPQ2
- C0MPQ3
- C0MPQ5
- C0MPQ6
- C0MPQ7
- C4R9J5
- C5IZL1
- O00259
- O19698
- O19700
- O19702
- O19749
- O46884
- O77952
- O98215
- O98216
- O98217
- O98218
- O98219
- O98222
- O98223
- P01916
- P04232
- P13763
- P79493
- P79608
- Q0P0L4
- Q0ZFN3
- Q14279
- Q27S71
- Q29682
- Q29684
- Q29698
- Q29714
- Q29775
- Q29776
- Q29778
- Q29779
- Q29781
- Q29827
- Q29828
- Q29879
- Q29880
- Q29898
- Q29977
- Q2MGW3
- Q30015
- Q30031
- Q30032
- Q30033
- Q30034
- Q30050
- Q30051
- Q30052
- Q30053
- Q30054
- Q30055
- Q30174
- Q4GY31
- Q4JHD8
- Q5ENE0
- Q5ENE1
- Q5ENW3
- Q5EP46
- Q5EP47
- Q5EP49
- Q5EP51
- Q5EP52
- Q5EP53
- Q5EP56
- Q5I4H8
- Q5I4H9
- Q5ISH4
- Q5ISH5
- Q5SQ73
- Q5STP2
- Q5YLA6
- Q6IVX1
- Q6LBX2
- Q6LBX3
- Q6LBX4
- Q6LBX5
- Q6LBX6
- Q6LBX7
- Q6PWX6
- Q6TAS4
- Q714U1
- Q714U2
- Q7YQ10
- Q860Z7
- Q8HWL7
- Q8HWT5
- Q8SNC4
- Q95HC1
- Q95IT7
- Q95IT8
- Q9BD13
- Q9GIM2
- Q9GIM4
- Q9GIX6
- Q9GJ41
- Q9MY67
- Q9TNT7
- Q9TQE2
- Q9XS11
- Q9XS12
Protein attributes for HLA-DPB1 Gene
- Size:
- 258 amino acids
- Molecular mass:
- 29159 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.
- SequenceCaution:
-
- Sequence=AAQ12564.1; Type=Frameshift; Positions=39; Evidence={ECO:0000305};
Protein Expression for HLA-DPB1 Gene
Post-translational modifications for HLA-DPB1 Gene
Other Protein References for HLA-DPB1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HLA-DPB1
-
Abcam antibodies for HLA-DPB1
- Invitrogen Antibodies for HLA-DPB1
- antibodies-online Antibodies for HLA-DPB1: See all 64
- GeneTex HLA-DPB1 antibody for HLA-DPB1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HLA-DPB1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HLA-DPB1
- Origene Custom Protein Services for HLA-DPB1
- antibodies-online Proteins for HLA-DPB1: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HLA-DPB1
-
Abcam proteins for HLA-DPB1
No data available for DME Specific Peptides for HLA-DPB1 Gene
Domains & Families for HLA-DPB1 Gene
Gene Families for HLA-DPB1 Gene
Protein Domains for HLA-DPB1 Gene
Suggested Antigen Peptide Sequences for HLA-DPB1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P04440- Family:
-
- Belongs to the MHC class II family.
Function for HLA-DPB1 Gene
Molecular function for HLA-DPB1 Gene
- GENATLAS Biochemistry:
- HLA-DP,beta chain
- UniProtKB/Swiss-Prot Function:
- Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0042605 | peptide antigen binding | IDA | 20356827 |
Phenotypes for HLA-DPB1 Gene
- GenomeRNAi human phenotypes for HLA-DPB1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HLA-DPB1
-
-
ViGene Biosciences ready-to-package AAV shRNAs for HLA-DPB1 gene
- Search ViGene Biosciences for HLA-DPB1
CRISPR Products
- Browse CRISPR knockouts for HLA-DPB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HLA-DPB1
- GenScript: Design CRISPR guide RNA sequences for HLA-DPB1
miRNA Products
- Search ViGene Biosciences for HLA-DPB1
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for HLA-DPB1 gene
Clone Products
- Sino Biological Human cDNA Clone for HLA-DPB1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HLA-DPB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HLA-DPB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for HLA-DPB1
-
ViGene Biosciences adenoviral particle packaged cDNA for HLA-DPB1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HLA-DPB1 gene
- Search ViGene Biosciences for HLA-DPB1
No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HLA-DPB1 Gene
Localization for HLA-DPB1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HLA-DPB1 Gene
- Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 5 |
| lysosome | 5 |
| golgi apparatus | 5 |
| endosome | 5 |
| extracellular | 2 |
| mitochondrion | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | TAS | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
Pathways & Interactions for HLA-DPB1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Allograft rejection |
.44
|
|
| 2 | Th17 cell differentiation | ||
| 3 | Translocation of ZAP-70 to Immunological synapse |
.71
|
|
| 4 | Immune response NFAT in immune response | ||
| 5 | Influenza A |
.34
|
|
Pathways by source for HLA-DPB1 Gene
1 BioSystems pathway for HLA-DPB1 Gene
13 Reactome pathways for HLA-DPB1 Gene
24 KEGG pathways for HLA-DPB1 Gene
6 GeneGo (Thomson Reuters) pathways for HLA-DPB1 Gene
Interacting Proteins for HLA-DPB1 Gene
Selected Interacting proteins:
P04440-DPB1_HUMAN
ENSP00000408146
for HLA-DPB1 Gene via
MINT
STRING
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | IEA | -- |
| GO:0006955 | immune response | IEA | -- |
| GO:0019882 | antigen processing and presentation | IEA | -- |
| GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | -- |
No data available for SIGNOR curated interactions for HLA-DPB1 Gene
Drugs & Compounds for HLA-DPB1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Aspirin | Approved, Vet_approved | Pharma | Channel blocker | 1152 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for HLA-DPB1 Gene
mRNA/cDNA for HLA-DPB1 Gene
- (1) REFSEQ mRNAs :
- (57) Additional mRNA sequences :
- (599) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HLA-DPB1 Gene
CRISPR Products
- Browse CRISPR knockouts for HLA-DPB1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HLA-DPB1
- GenScript: Design CRISPR guide RNA sequences for HLA-DPB1
miRNA Products
- Search ViGene Biosciences for HLA-DPB1
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for HLA-DPB1 gene
Clone Products
- Sino Biological Human cDNA Clone for HLA-DPB1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HLA-DPB1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HLA-DPB1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for HLA-DPB1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Blood (Cardiovascular System)
- T Helper Cells Thymus
- Eye (Sensory Organs)
-
Spleen (Hematopoietic System)
-
Tonsil (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for HLA-DPB1 Gene
This gene is overexpressed in Spleen (x5.0) and Whole Blood (x4.5).
This gene is overexpressed in Skin (24.3), Breast (8.0), and Lymph node (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HLA-DPB1 Gene
SOURCE GeneReport for Unigene cluster for HLA-DPB1 Gene:
Hs.485130Evidence on tissue expression from TISSUES for HLA-DPB1 Gene
- Blood(4.7)
- Spleen(4.5)
- Lung(4)
- Bone marrow(2.7)
- Nervous system(2.5)
- Intestine(2.2)
- Kidney(2.2)
- Pancreas(2.2)
- Lymph node(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-DPB1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- nervous
- respiratory
- skeleton
- urinary
Organs:
Head and neck:
- brain
- ear
- eye
- face
- head
- larynx
- mouth
- neck
- nose
- pituitary gland
- sinus
- skull
Thorax:
- bronchus
- esophagus
- heart
- lung
- trachea
Abdomen:
- kidney
- stomach
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- blood vessel
- coagulation system
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- white blood cell
Primer Products
No data available for mRNA Expression by UniProt/SwissProt for HLA-DPB1 Gene
Orthologs for HLA-DPB1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PATR-DPB1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | BOLA-DRB3 35 |
|
ManyToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| dog (Canis familiaris) |
Mammalia | HLA-DPB1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | BLB3 34 |
|
- Species where no ortholog for HLA-DPB1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HLA-DPB1 Gene
Paralogs for HLA-DPB1 Gene
(114) SIMAP similar genes for HLA-DPB1 Gene using alignment to 265 proteins:
- DPB1_HUMAN
- A0RZF7_HUMAN
- A0RZF8_HUMAN
- A0RZF9_HUMAN
- A0RZG0_HUMAN
- A1YAC1_HUMAN
- A8I207_HUMAN
- B5U899_HUMAN
- B5U8B5_HUMAN
- B9W6F8_HUMAN
- C0MPQ4_HUMAN
- C8ZLH7_HUMAN
- D0AB31_HUMAN
- D0AB33_HUMAN
- D1H103_HUMAN
- D1H104_HUMAN
- D2ECD5_HUMAN
- D2ECG1_HUMAN
- D2EDB6_HUMAN
- D2U7E3_HUMAN
- D4IIJ3_HUMAN
- D5GXL3_HUMAN
- D6CIB0_HUMAN
- D6CIB1_HUMAN
- E1XU79_HUMAN
- E1Y7U4_HUMAN
- E5AXX6_HUMAN
- E9NVG1_HUMAN
- F2QL91_HUMAN
- F2QL92_HUMAN
- F5ATB2_HUMAN
- F5H135_HUMAN
- G3CCE6_HUMAN
- H0Y5P2_HUMAN
- H0Y7G7_HUMAN
- H2A3H7_HUMAN
- H2A9R0_HUMAN
- H6V6L0_HUMAN
- I2E6J3_HUMAN
- I2FL84_HUMAN
- I3RVA4_HUMAN
- I4EC15_HUMAN
- I4EC16_HUMAN
- I4EC17_HUMAN
- I4EC18_HUMAN
- I4EC19_HUMAN
- I4EC21_HUMAN
- I4EC22_HUMAN
- J9U8C4_HUMAN
- K0JBZ5_HUMAN
- K0JCD0_HUMAN
- K0P2W9_HUMAN
- K0PBH6_HUMAN
- K4NS58_HUMAN
- K7WPG8_HUMAN
- K7X4E9_HUMAN
- L0BXH6_HUMAN
- L0BXX2_HUMAN
- L8B8W7_HUMAN
- L8BT22_HUMAN
- M4MD27_HUMAN
- M4MD46_HUMAN
- M4QBZ6_HUMAN
- M4QCA7_HUMAN
- N0A0S2_HUMAN
- N0A2U5_HUMAN
- N0A4F7_HUMAN
- N0A934_HUMAN
- N0AA99_HUMAN
- O19699_HUMAN
- O19701_HUMAN
- Q05853_HUMAN
- Q29683_HUMAN
- Q29774_HUMAN
- Q29860_HUMAN
- Q29881_HUMAN
- Q29956_HUMAN
- Q2PZR0_HUMAN
- Q2UVJ2_HUMAN
- Q30012_HUMAN
- Q30013_HUMAN
- Q30014_HUMAN
- Q30016_HUMAN
- Q30017_HUMAN
- Q30018_HUMAN
- Q30019_HUMAN
- Q30020_HUMAN
- Q30021_HUMAN
- Q30022_HUMAN
- Q30023_HUMAN
- Q30024_HUMAN
- Q30025_HUMAN
- Q30026_HUMAN
- Q30027_HUMAN
- Q30028_HUMAN
- Q30029_HUMAN
- Q30030_HUMAN
- Q30037_HUMAN
- Q30038_HUMAN
- Q30039_HUMAN
- Q30040_HUMAN
- Q30041_HUMAN
- Q30042_HUMAN
- Q30043_HUMAN
- Q30044_HUMAN
- Q30045_HUMAN
- Q30046_HUMAN
- Q30049_HUMAN
- Q30059_HUMAN
- Q30060_HUMAN
- Q30214_HUMAN
- Q31619_HUMAN
- Q49U28_HUMAN
- Q49U30_HUMAN
- Q49U32_HUMAN
- Q49U34_HUMAN
- Q49U36_HUMAN
- Q49U38_HUMAN
- Q49U40_HUMAN
- Q49U42_HUMAN
- Q49U44_HUMAN
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- HLA-SB beta
- HLA-DPB
- HLA-DP
- DPB1
- MHC DPB1
- HLA-DB1
- MHC-DPB1*6001
- HLA-D8.2V
- HLA-DRB13
- HLA-DRB1*1327
- HLA-DRB4*0102
- HLA-DRB14
- HLA-DRB1*0801
- HLQ-DQB1
- HLA-DRB1*11
- HLA-DRB1*1125
- HLA-DRBI*1303
- HLA-DRB1*1605
- DRB1*08
- DRB52
- HLA-DBR1
- HLA DRB4
- MHC class II HLA-DRB1 Exon-2
- HLA-DR4
- MHC Class II HLA DRB1
- DRB1*0405V3
- HLA-DRB1*04
- HLA DRB1 gene
- HLA-DR4/Dw13
- HLA-DRB1*1324
- HLA DRB1
- HLA-DR-beta 1
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- HLA-DRBI
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- DRB1 HAG
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- HLA DRB1*1202
- HLA-DRB
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- HLA-DRB1*
- MHC class II HLA DRB1
- HLADRB1
- DRB1
- HLA-DR
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- HLA-DRB1*1302Var
- HLA-DRB1-0811
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- HLA-DR beta
- DRB1*1116
- HLA-DRB1*0818
- HLA-DRB3*01
- HLA-DRB52
- HLA-DRB1-1113
- HLA-DRB1*08
- HLA-D
- HLA-DRB3
- HLA-DR15
- DRB1*LY10
- MHC class II HLA DRB1-0305
- HLA-DR3
- HLA-DRB4
- HLA-DR-beta
- HLA-DRB5
- HLA
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- HLA-DQB1I
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- HLA-C
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- HLA-DQB1*05
- HLA-A
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- HLA-DPA1
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- HFE
- IGLC6
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- IGLC1
- C1 segment
- IGLC7
- IGLC3
- IGLC2
- DKFZp667J0810
- HLA-A*0201V3
- HLA-B
- HLA-G
Pseudogenes.org Pseudogenes for HLA-DPB1 Gene
Variants for HLA-DPB1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DPB1 Gene
- DPB1_HUMAN-P04440
- The following alleles of HLA-DPB1 are known: DPB1*01:01, DPB1*01:02, DPB1*02:01, DPB1*02:02, DPB1*02:03, DPB1*03:01, DPB1*03:02, DPB1*04:01, DPB1*04:02, DPB1*04:03, DPB1*05:01, DPB1*05:02, DPB1*06:01, DPB1*06:02, DPB1*08:01, DPB1*08:02, DPB1*09:01, DPB1*09:02, DPB1*10:01, DPB1*10:02, DPB1*11:01, DPB1*11:02, DPB1*13:01, DPB1*13:02, DPB1*14:01, DPB1*14:02, DPB1*15:01, DPB1*15:02, DPB1*16:01, DPB1*16:02, DPB1*17:01, DPB1*17:02, DPB1*18:01, DPB1*18:02, DPB1*19:01, DPB1*19:02, DPB1*20:01, DPB1*20:02, DPB1*21:01, DPB1*21:02, DPB1*22:01, DPB1*22:02, DPB1*23:01, DPB1*24:01, DPB1*24:02, DPB1*25:01, DPB1*25:02, DPB1*26:01, DPB1*26:02, DPB1*27:01, DPB1*28:01, DPB1*29:01, DPB1*30:01, DPB1*31:01, DPB1*32:01, DPB1*33:01, DPB1*34:01, DPB1*35:01, DPB1*36:01, DPB1*37:01, DPB1*38:01, DPB1*39:01, DPB1*40:01, DPB1*41:01, DPB1*44:01, DPB1*45:01, DPB1*46:01, DPB1*47:01, DPB1*48:01, DPB1*49:01, DPB1*50:01, DPB1*51:01, DPB1*52:01, DPB1*53:01, DPB1*54:01, DPB1*55:01, DPB1*56:01, DPB1*57:01, DPB1*58:01, DPB1*59:01, DPB1*60:01, DPB1*62:01, DPB1*63:01, DPB1*65:01, DPB1*66:01, DPB1*67:01, DPB1*68:01, DPB1*69:01, DPB1*70:01, DPB1*71:01, DPB1*72:01, DPB1*73:01, DPB1*74:01, DPB1*75:01, DPB1*76:01, DPB1*77:01, DPB1*78:01, DPB1*79:01, DPB1*80:01, DPB1*81:01, DPB1*82:01, DPB1*83:01, DPB1*84:01, DPB1*85:01, DPB1*86:01, DPB1*87:01, DPB1*88:01, DPB1*89:01, DPB1*90:01, DPB1*91:01, DPB1*92:01, DPB1*93:01, DPB1*94:01, DPB1*95:01, DPB1*96:01, DPB1*97:01, DPB1*98:01 and DPB1*99:01. The sequence shown is that of DPB1*04:01.
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1042140 | other | 33,080,863(+) | AGGAG(A/C/G/T)AGCGG | upstream-variant-2KB, reference, missense | |
| rs1000127410 | -- | 33,078,551(+) | TTCAG(A/C)TCAGT | intron-variant | |
| rs1000254634 | -- | 33,087,415(+) | TTTTT(G/T)TTTTC | utr-variant-3-prime | |
| rs1000357828 | -- | 33,076,538(+) | CCAGG(C/T)TCTGA | intron-variant | |
| rs1000705128 | -- | 33,087,974(+) | AACTA(C/T)AAAGG | utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1000e201 | CNV | deletion | 23290073 |
| dgv1040n67 | CNV | loss | 20364138 |
| dgv1041n67 | CNV | loss | 20364138 |
| dgv1042n67 | CNV | loss | 20364138 |
| esv1006913 | CNV | gain | 20482838 |
| esv22467 | CNV | loss | 19812545 |
| esv2731879 | CNV | deletion | 23290073 |
| esv3570995 | CNV | loss | 25503493 |
| nsv1024429 | CNV | loss | 25217958 |
| nsv1073969 | CNV | deletion | 25765185 |
| nsv1112900 | CNV | deletion | 24896259 |
| nsv1119076 | CNV | deletion | 24896259 |
| nsv462892 | CNV | loss | 19166990 |
| nsv516221 | CNV | loss | 19592680 |
| nsv602818 | CNV | loss | 21841781 |
| nsv602823 | CNV | loss | 21841781 |
| nsv602824 | CNV | loss | 21841781 |
| nsv819171 | CNV | loss | 19587683 |
| nsv823645 | CNV | loss | 20364138 |
| nsv823656 | CNV | loss | 20364138 |
| nsv970108 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
28.14;
99.85% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HLA-DPB1 Gene
Disorders for HLA-DPB1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chronic beryllium disease |
|
|
| wegener granulomatosis |
|
|
| posner-schlossman syndrome |
|
|
| beryllium disease |
|
|
| neonatal lupus erythematosus |
|
|
Search HLA-DPB1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HLA-DPB1
No data available for UniProtKB/Swiss-Prot and Genatlas for HLA-DPB1 Gene
Publications for HLA-DPB1 Gene
- Effect of human leukocyte antigen homozygosity on rubella vaccine-induced humoral and cell-mediated immune responses. (PMID: 19896518) Kennedy R.B. … Poland G.A. (Hum. Immunol. 2010) 3 22 46 64
- Association of the HLA-DPB1*0501 allele with anti-aquaporin-4 antibody positivity in Japanese patients with idiopathic central nervous system demyelinating disorders. (PMID: 19140826) Matsushita T. … Kira J. (Tissue Antigens 2009) 3 22 46 64
- Analysis of maternal-offspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes. (PMID: 19143818) Bronson P.G. … Barcellos L.F. (Diabetes Obes Metab 2009) 3 22 46 64
- HLA-DPB1 and NFKBIL1 may confer the susceptibility to chronic thromboembolic pulmonary hypertension in the absence of deep vein thrombosis. (PMID: 19165231) Kominami S. … Kimura A. (J. Hum. Genet. 2009) 3 22 46 64
- Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controls. (PMID: 18486765) Noble J.A. … Erlich H.A. (Hum. Immunol. 2008) 3 22 46 64
Products for HLA-DPB1 Gene
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