Aliases for HLA-DPA1 Gene
Aliases for HLA-DPA1 Gene
External Ids for HLA-DPA1 Gene
- HGNC: 4938
- Entrez Gene: 3113
- Ensembl: ENSG00000231389
- OMIM: 142880
- UniProtKB: P20036
Previous HGNC Symbols for HLA-DPA1 Gene
- HLA-DP1A
Previous GeneCards Identifiers for HLA-DPA1 Gene
- GC06U990043
- GC06M033029
- GC06M033079
- GC06M033140
- GC06M032775
Summaries for HLA-DPA1 Gene
-
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]
GeneCards Summary for HLA-DPA1 Gene
HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1) is a Protein Coding gene. Diseases associated with HLA-DPA1 include Posner-Schlossman Syndrome and Inflammatory Bowel Disease 3. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include peptide antigen binding and MHC class II receptor activity. An important paralog of this gene is HLA-DRA.
UniProtKB/Swiss-Prot for HLA-DPA1 Gene
-
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-DPA1 Gene
Genomics for HLA-DPA1 Gene
Regulatory Elements for HLA-DPA1 Gene
Enhancers for HLA-DPA1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HLA-DPA1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HLA-DPA1 gene promoter:
Regulatory Element Products
Genomic Location for HLA-DPA1 Gene
- Chromosome:
- 6
- Start:
- 33,064,569 bp from pter
- End:
- 33,080,778 bp from pter
- Size:
- 16,210 bases
- Orientation:
- Minus strand
Genomic View for HLA-DPA1 Gene
Genes around HLA-DPA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.32 by Ensembl
- 6p21.32 by Entrez Gene
- 6p21.32 by HGNC
HLA-DPA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HLA-DPA1 Gene
Proteins for HLA-DPA1 Gene
-
Protein details for HLA-DPA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P20036-DPA1_HUMAN
- Recommended name:
- HLA class II histocompatibility antigen, DP alpha 1 chain
- Protein Accession:
- P20036
- A9YWH7
- B9UKH4
- O19722
- O46883
- P01905
- P79554
- Q2Q060
- Q2Q061
- Q5EY03
- Q5STP1
- Q6DQK4
- Q9BCQ1
- Q9TPX3
- Q9XS10
Protein attributes for HLA-DPA1 Gene
- Size:
- 260 amino acids
- Molecular mass:
- 29381 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.
- SequenceCaution:
-
- Sequence=AAC64233.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAD42927.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for HLA-DPA1 Gene
Post-translational modifications for HLA-DPA1 Gene
Other Protein References for HLA-DPA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HLA-DPA1
-
Abcam antibodies for HLA-DPA1
- Invitrogen Antibodies for HLA-DPA1
- antibodies-online Antibodies for HLA-DPA1: See all 50
- GeneTex HLA-DPA1 antibody for HLA-DPA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HLA-DPA1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HLA-DPA1
- Origene Custom Protein Services for HLA-DPA1
- antibodies-online Proteins for HLA-DPA1: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HLA-DPA1
-
Abcam proteins for HLA-DPA1
Assay Products
- antibodies-online Kits for HLA-DPA1: See all 1
No data available for DME Specific Peptides for HLA-DPA1 Gene
Domains & Families for HLA-DPA1 Gene
Gene Families for HLA-DPA1 Gene
Protein Domains for HLA-DPA1 Gene
Suggested Antigen Peptide Sequences for HLA-DPA1 Gene
- GenScript: Design optimal peptide antigens:
-
- Major histocompatibility complex, class II, DP alpha 1 (A2ABA4_HUMAN)
- Major histocompatibility complex, class II, DP alpha 1 (A2ABA5_HUMAN)
- Major histocompatibility complex, class II, DP alpha 1 (A2ABA6_HUMAN)
- Major histocompatibility complex, class II, DP alpha 1 (A2ALJ1_HUMAN)
- Major histocompatibility complex, class II, DP alpha 1 (A2ALJ2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P20036- Family:
-
- Belongs to the MHC class II family.
Function for HLA-DPA1 Gene
Molecular function for HLA-DPA1 Gene
- GENATLAS Biochemistry:
- HLA-DP,alpha chain
- UniProtKB/Swiss-Prot Function:
- Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0032395 | MHC class II receptor activity | NAS | 2461352 |
| GO:0042605 | peptide antigen binding | IDA | 20356827 |
Phenotypes for HLA-DPA1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences ready-to-package AAV shRNAs for HLA-DPA1 gene
- Search ViGene Biosciences for HLA-DPA1
CRISPR Products
- Browse CRISPR knockouts for HLA-DPA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HLA-DPA1
- GenScript: Design CRISPR guide RNA sequences for HLA-DPA1
miRNA for HLA-DPA1 Gene
- miRTarBase miRNAs that target HLA-DPA1
miRNA Products
- Search ViGene Biosciences for HLA-DPA1
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for HLA-DPA1 gene
Clone Products
- Sino Biological Human cDNA Clone for HLA-DPA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HLA-DPA1
-
ViGene Biosciences adenoviral particle packaged cDNA for HLA-DPA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HLA-DPA1 gene
- Search ViGene Biosciences for HLA-DPA1
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-DPA1 Gene
Localization for HLA-DPA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HLA-DPA1 Gene
- Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 5 |
| lysosome | 5 |
| golgi apparatus | 5 |
| endosome | 5 |
| extracellular | 1 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005764 | lysosome | IEA | -- |
| GO:0005765 | lysosomal membrane | TAS | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
Pathways & Interactions for HLA-DPA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Allograft rejection |
.44
|
|
| 2 | Th17 cell differentiation | ||
| 3 | Translocation of ZAP-70 to Immunological synapse |
.71
|
|
| 4 | ICos-ICosL Pathway in T-Helper Cell | ||
| 5 | TCR Signaling (Qiagen) |
.68
|
|
Pathways by source for HLA-DPA1 Gene
1 BioSystems pathway for HLA-DPA1 Gene
13 Reactome pathways for HLA-DPA1 Gene
24 KEGG pathways for HLA-DPA1 Gene
6 GeneGo (Thomson Reuters) pathways for HLA-DPA1 Gene
12 Qiagen pathways for HLA-DPA1 Gene
Interacting Proteins for HLA-DPA1 Gene
Selected Interacting proteins:
P20036-DPA1_HUMAN
ENSP00000393566
for HLA-DPA1 Gene via
MINT
STRING
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002376 | immune system process | IEA | -- |
| GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | IEA | -- |
| GO:0006955 | immune response | IEA,NAS | 2461352 |
| GO:0019882 | antigen processing and presentation | IEA | -- |
| GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | -- |
No data available for SIGNOR curated interactions for HLA-DPA1 Gene
Drugs & Compounds for HLA-DPA1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Peginterferon alfa-2b | Approved | Pharma | 307 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for HLA-DPA1 Gene
mRNA/cDNA for HLA-DPA1 Gene
- (3) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (699) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HLA-DPA1 Gene
- Major histocompatibility complex, class II, DP alpha 1:
- Representative Sequences:
CRISPR Products
- Browse CRISPR knockouts for HLA-DPA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HLA-DPA1
- GenScript: Design CRISPR guide RNA sequences for HLA-DPA1
miRNA Products
- Search ViGene Biosciences for HLA-DPA1
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for HLA-DPA1 gene
Clone Products
- Sino Biological Human cDNA Clone for HLA-DPA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HLA-DPA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Plasmacytoid Dendritic cells Peripheral Blood
- T Helper Cells Thymus
-
Eye (Sensory Organs)
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Conjunctival Epithelium
- Inner Cell Mass (Early Embryonic Tissues)
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Epithelial Cells
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Umbilical Cord (Extraembryonic Tissues)
-
Tonsil (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for HLA-DPA1 Gene
This gene is overexpressed in Whole Blood (x4.2) and Spleen (x4.0).
This gene is overexpressed in Blymphocyte (12.0), Lymph node (10.2), and Lung (8.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HLA-DPA1 Gene
- Elite partner
SOURCE GeneReport for Unigene cluster for HLA-DPA1 Gene:
Hs.347270Evidence on tissue expression from TISSUES for HLA-DPA1 Gene
- Liver(4.3)
- Lung(4.1)
- Nervous system(3.8)
- Pancreas(3.1)
- Spleen(2.6)
- Kidney(2.3)
- Intestine(2.2)
- Blood(2.1)
Primer Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-DPA1 Gene
Orthologs for HLA-DPA1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PATR-DPA1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | BOLA-DYA 35 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100332204 34 |
|
||
| si:busm1-160c18.1 35 |
|
ManyToMany |
- Species where no ortholog for HLA-DPA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HLA-DPA1 Gene
Paralogs for HLA-DPA1 Gene
(31) SIMAP similar genes for HLA-DPA1 Gene using alignment to 79 proteins:
- DPA1_HUMAN
- D9YLZ6_HUMAN
- F6V115_HUMAN
- G3GJV6_HUMAN
- H0Y6F8_HUMAN
- H9BIJ2_HUMAN
- I2G9G1_HUMAN
- J3KQ99_HUMAN
- J9UEA6_HUMAN
- K4PDP4_HUMAN
- N0A0E5_HUMAN
- O78000_HUMAN
- O98050_HUMAN
- Q29ZM9_HUMAN
- Q29ZN0_HUMAN
- Q29ZN1_HUMAN
- Q29ZN2_HUMAN
- Q29ZN3_HUMAN
- Q29ZN4_HUMAN
- Q49U27_HUMAN
- Q49U29_HUMAN
- Q49U31_HUMAN
- Q49U33_HUMAN
- Q49U35_HUMAN
- Q49U37_HUMAN
- Q49U39_HUMAN
- Q49U41_HUMAN
- Q49U43_HUMAN
- Q49U45_HUMAN
- Q49U47_HUMAN
- Q49U49_HUMAN
- Q49U51_HUMAN
- Q49U53_HUMAN
- Q49U55_HUMAN
- Q49U57_HUMAN
- Q49U59_HUMAN
- Q49U61_HUMAN
- Q49U63_HUMAN
- Q49U65_HUMAN
- Q49U67_HUMAN
- Q49U69_HUMAN
- Q49U71_HUMAN
- Q5EY04_HUMAN
- Q67AL9_HUMAN
- Q67AM0_HUMAN
- Q67AM1_HUMAN
- Q67AM2_HUMAN
- Q67AM3_HUMAN
- Q67AM4_HUMAN
- Q67AM5_HUMAN
- Q67AM6_HUMAN
- Q67AM7_HUMAN
- Q67AM8_HUMAN
- Q67AM9_HUMAN
- Q67AN0_HUMAN
- Q67AN1_HUMAN
- Q67AN2_HUMAN
- Q67AR8_HUMAN
- Q67AS2_HUMAN
- Q67AS8_HUMAN
- Q67AS9_HUMAN
- Q67AT4_HUMAN
- Q67AT8_HUMAN
- Q67AT9_HUMAN
- Q67AU0_HUMAN
- Q67AU1_HUMAN
- Q67AU2_HUMAN
- Q67AU3_HUMAN
- Q67AU4_HUMAN
- Q67AU5_HUMAN
- Q67AU6_HUMAN
- Q67AU7_HUMAN
- Q67AU8_HUMAN
- Q67AU9_HUMAN
- Q9TPP2_HUMAN
- Q9TQA9_HUMAN
- Q9TQB0_HUMAN
- Q9XS09_HUMAN
- V5N4B3_HUMAN
Variants for HLA-DPA1 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DPA1 Gene
- DPA1_HUMAN-P20036
- The following alleles of DPA1 are known: DPA1*01:03, DPA1*01:04, DPA1*01:05, DPA1*01:06, DPA1*01:07, DPA1*01:08, DPA1*01:09, DPA1*01:10, DPA1*02:01, DPA1*02:02, DPA1*02:03, DPA1*02:04, DPA1*03:01, DPA1*03:02, DPA1*03:03, DPA1*04:01 The sequence shown is that of DPA1*01:03.
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1042140 | other | 33,080,863(+) | AGGAG(A/C/G/T)AGCGG | upstream-variant-2KB, reference, missense | |
| rs1000127410 | -- | 33,078,551(+) | TTCAG(A/C)TCAGT | intron-variant | |
| rs1000357828 | -- | 33,076,538(+) | CCAGG(C/T)TCTGA | intron-variant | |
| rs1000615064 | -- | 33,065,006(+) | AGAGT(C/T)TCCCC | utr-variant-3-prime | |
| rs1000958471 | -- | 33,075,239(+) | TTGAT(C/T)TTAAG | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1039n67 | CNV | loss | 20364138 |
| dgv1040n67 | CNV | loss | 20364138 |
| esv1006913 | CNV | gain | 20482838 |
| esv22467 | CNV | loss | 19812545 |
| esv2545651 | CNV | loss | 19546169 |
| esv2731879 | CNV | deletion | 23290073 |
| nsv1024429 | CNV | loss | 25217958 |
| nsv1073969 | CNV | deletion | 25765185 |
| nsv1112900 | CNV | deletion | 24896259 |
| nsv1119076 | CNV | deletion | 24896259 |
| nsv602818 | CNV | loss | 21841781 |
| nsv602819 | CNV | loss | 21841781 |
| nsv602822 | CNV | loss | 21841781 |
| nsv819387 | CNV | loss | 19587683 |
| nsv823641 | CNV | loss | 20364138 |
| nsv823645 | CNV | loss | 20364138 |
| nsv823646 | CNV | loss | 20364138 |
| nsv823647 | CNV | loss | 20364138 |
| nsv823648 | CNV | loss | 20364138 |
| nsv823649 | CNV | loss | 20364138 |
| nsv823650 | CNV | loss | 20364138 |
| nsv970108 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
96.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
18.70;
98.65% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HLA-DPA1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HLA-DPA1
Disorders for HLA-DPA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| posner-schlossman syndrome |
|
|
| inflammatory bowel disease 3 |
|
|
Search HLA-DPA1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HLA-DPA1
No data available for UniProtKB/Swiss-Prot and Genatlas for HLA-DPA1 Gene
Publications for HLA-DPA1 Gene
- Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes. (PMID: 6584734) Auffray C. … Strominger J.L. (Nature 1984) 2 3 4 64
- Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population. (PMID: 21274863) Guo X. … O'Brien S.J. (Hepatology 2011) 3 46 64
- A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. (PMID: 21750111) Mbarek H. … Matsuda K. (Hum. Mol. Genet. 2011) 3 46 64
- Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. (PMID: 21814517) Noguchi E. … Matsumoto K. (PLoS Genet. 2011) 3 46 64
- Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. (PMID: 21779181) Gorlova O. … Martin J. (PLoS Genet. 2011) 3 46 64
Products for HLA-DPA1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
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- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HLA-DPA1
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- GenScript: Next-day shipping cDNA ORF clone for HLA-DPA1 in any vector
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- Novus Biologicals Antibodies for HLA-DPA1
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- antibodies-online Antibodies for HLA-DPA1: See all 50
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- GeneTex HLA-DPA1 antibody for HLA-DPA1
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- ViGene Biosciences adenoviral particle packaged cDNA for HLA-DPA1 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for HLA-DPA1
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- Horizon Cell Lines for HLA-DPA1
- Cyagen custom Knockout/knockin (KOKI) mouse models for HLA-DPA1
- VectorBuilder custom plasmid, inducible vectors for HLA-DPA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HLA-DPA1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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