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HLA-DPA1 Gene

protein-coding   GIFtS: 61
GCID: GC06M033032

Major Histocompatibility Complex, Class II, DP Alpha 1


(Previous symbol: HLA-DP1A)
  See HLA-DPA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Major Histocompatibility Complex, Class II, DP Alpha 11 2     HLADP2 5
HLA-DP1A1 2 3     PLT12
DP(W3)2 3     HLA Class II Histocompatibility Antigen, DP Alpha 1 Chain2
DP(W4)2 3     MHC Class II Antigen2
HLASB2 3     MHC Class II HLA-DPA1 Antigen2
HLA-SB Alpha Chain2 3     Primed Lymphocyte Test-12
MHC Class II DP3-Alpha2 3     MHC Class II DPA13

External Ids:    HGNC: 49381   Entrez Gene: 31132   Ensembl: ENSG000002313897   OMIM: 1428805   UniProtKB: P200363   

Export aliases for HLA-DPA1 gene to outside databases

Previous GC identifers: GC06U990043 GC06M033029 GC06M033079 GC06M033140 GC06M032775


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HLA-DPA1 Gene:
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of
an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune
system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen
presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa
and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular
domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha
chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up
to 4 different molecules. (provided by RefSeq, Jul 2008)

GeneCards Summary for HLA-DPA1 Gene:
HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) is a protein-coding gene. Diseases associated with HLA-DPA1 include berylliosis, and acute disseminated encephalomyelitis. GO annotations related to this gene include MHC class II receptor activity. An important paralog of this gene is HLA-DRB5.

UniProtKB/Swiss-Prot: DPA1_HUMAN, P20036
Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
(class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the
regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
efficient peptide loading




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167244.2  NT_167245.2  NT_167246.2  NT_167247.2  
NT_167248.2  NT_167249.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HLA-DPA1 gene promoter:
         GR   NRSF form 1   p300   CUTL1   MIF-1   NRSF form 2   PPAR-alpha   STAT3   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLA-DPA1 promoter sequence
   Search Chromatin IP Primers for HLA-DPA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-DPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

HLA-DPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-DPA1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M033032:  view genomic region     (about GC identifiers)

Start:
33,032,346 bp from pter      End:
33,048,555 bp from pter
Size:
16,210 bases      Orientation:
minus strand

Selected alternative locations (see all 7):
Chr6-,NT_113891.2 4,476,526-4,492,734      Chr6-,NT_167245 4,313,685-4,329,894      Chr6-,NT_167247 4,369,219-4,385,416     
Chr6-,NT_167246 4,489,886-4,506,101      Chr6-,NT_167249 4,512,850-4,529,059      Chr6-,NT_167248 4,264,797-4,281,012     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DPA1_HUMAN, P20036 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen, DP alpha 1 chain precursor  
Size: 260 amino acids; 29381 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Sequence caution: Sequence=AAC64233.1; Type=Erroneous gene model prediction; Sequence=AAD42927.1; Type=Erroneous
gene model prediction;
1 PDB 3D structure from and Proteopedia for HLA-DPA1:
3LQZ (3D)    
Secondary accessions: A9YWH7 B9UKH4 O19722 O46883 P01905 P79554 Q2Q060 Q2Q061 Q5EY03 Q5STP1
Q6DQK4 Q9BCQ1 Q9TPX3 Q9XS10

Explore the universe of human proteins at neXtProt for HLA-DPA1: NX_P20036

Explore proteomics data for HLA-DPA1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn109, Asn149
  • Modification sites at PhosphoSitePlus

  • See HLA-DPA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001229453.1  NP_001229454.1  NP_291032.2  

    ENSEMBL proteins: 
     ENSP00000393566   ENSP00000405500   ENSP00000390929   ENSP00000398134   ENSP00000402872  
    Reactome Protein details: P20036

    HLA-DPA1 Human Recombinant Protein Products:

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    Novus Biologicals HLA-DPA1 Protein
    Novus Biologicals HLA-DPA1 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HLA-DPA1 

     
    antibodies-online proteins for HLA-DPA1 (2 products) 

     
    antibodies-online peptides for HLA-DPA1

    HLA-DPA1 Antibody Products:

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    Search eBioscience for ELISAs for HLA-DPA1 
    antibodies-online kits for HLA-DPA1 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HLA: Histocompatibility complex
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    Selected InterPro protein domains (see all 7):
     IPR001003 MHC_II_a_N
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR014745 MHC_II_a/b_N
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry P20036

    ProtoNet protein and cluster: P20036

    2 Blocks protein domains:
    IPB001003 MHC Class II alpha chain
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: DPA1_HUMAN, P20036
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Find genes that share domains with HLA-DPA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPA1_HUMAN, P20036
    Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
    and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
    peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
    of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
    hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
    via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
    As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
    contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
    endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
    MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
    epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
    tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
    an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
    of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
    degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
    (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
    the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
    affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
    membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
    Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the
    regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
    efficient peptide loading

         Genatlas biochemistry entry for HLA-DPA1:
    HLA-DP,alpha chain

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0032395MHC class II receptor activity NAS2461352
         
    Find genes that share ontologies with HLA-DPA1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HLA-DPA1

    miRNA
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    Block miRNA regulation of human, mouse, rat HLA-DPA1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate HLA-DPA1:
    hsa-miR-877* hsa-miR-631 hsa-miR-3661
    SwitchGear 3'UTR luciferase reporter plasmidHLA-DPA1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat HLA-DPA1

    Gene Editing
    Products:
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    Clone
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    Sino Biological Human cDNA Clone for HLA-DPA1
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DPA1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DPA1_HUMAN, P20036: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
    Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
    protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
    protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic
    pathway until it reaches the cell membrane for antigen presentation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome5
    lysosome5
    plasma membrane5
    vacuole5
    golgi apparatus4
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005765lysosomal membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS2461352
    GO:0010008endosome membrane IEA--

    Find genes that share ontologies with HLA-DPA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HLA-DPA1 About   (see all 25)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Allograft rejection
    Allograft rejection0.86
    Intestinal immune network for IgA production0.41
    Allograft Rejection0.86
    Viral myocarditis0.40
    Type I diabetes mellitus0.69
    CTL Mediated Apoptosis0.38
    Graft-versus-host disease0.65
    THC Differentiation Pathway0.38
    2CD28 co-stimulation
    Costimulation by the CD28 family0.44
    CTLA4 Signaling0.30
    3Translocation of ZAP-70 to Immunological synapse
    Translocation of ZAP-70 to Immunological synapse0.83
    PD-1 signaling0.72
    Phosphorylation of CD3 and TCR zeta chains0.83
    Generation of second messenger molecules0.62
    4Immune response Antigen presentation by MHC class II
    Immune response Antigen presentation by MHC class II0.46
    Immune response IL 22 signaling pathway0.31
    G protein signaling N RAS regulation pathway0.46
    5ICos-ICosL Pathway in T-Helper Cell
    ICos-ICosL Pathway in T-Helper Cell0.66
    Calcium Mediated T-Cell Apoptosis0.31
    CD28 Signaling in T-Helper Cell0.66


    Find genes that share SuperPaths with HLA-DPA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HLA-DPA1 (see all 12)
        THC Differentiation Pathway
    Calcium Mediated T-Cell Apoptosis
    IL-4 Pathway
    ICos-ICosL Pathway in T-Helper Cell
    CDC42 Pathway

    Selected GeneGo (Thomson Reuters) Pathways for HLA-DPA1 (see all 6)
        Immune response Antigen presentation by MHC class II
    Immune response ICOS pathway in T-helper cell
    Immune response T cell receptor signaling pathway
    Immune response IL-22 signaling pathway
    G-protein signaling N-RAS regulation pathway

    1 BioSystems Pathway for HLA-DPA1
        Allograft Rejection

    1 Sino Biological Pathway for HLA-DPA1
        NF-kB (NFkB) Pathway

    Selected Reactome Pathways for HLA-DPA1 (see all 7)
        Translocation of ZAP-70 to Immunological synapse
    Interferon gamma signaling
    Downstream TCR signaling
    PD-1 signaling
    MHC class II antigen presentation


    Selected Kegg Pathways  (Kegg details for HLA-DPA1) (see all 21):
        Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Intestinal immune network for IgA production
    Type I diabetes mellitus

        Pathway & Disease-focused RT2 Profiler PCR Array including HLA-DPA1: 
              Antigen Presenting Cells in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HLA-DPA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for HLA-DPA1 (P200362, 3 ENSP000003935664) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD74P042332, 3, ENSP000000095304MINT-72790 I2D: score=2 STRING: ENSP00000009530
    HLA-DPB1P044403, ENSP000004081464I2D: score=1 STRING: ENSP00000408146
    ENSG00000215048P044403I2D: score=1 
    ENSG00000226826P044403I2D: score=1 
    ENSG00000230763P044403I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002504antigen processing and presentation of peptide or polysaccharide antigen via MHC class II ----
    GO:0006955immune response NAS2461352
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0019882antigen processing and presentation ----
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    Find genes that share ontologies with HLA-DPA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HLA-DPA1 (DPA1)

    1 Novoseek inferred chemical compound relationship for HLA-DPA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpa 1 95 5 9154456 (3), 8225437 (1)



    Find genes that share compounds with HLA-DPA1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HLA-DPA1 gene (3 alternative transcripts): 
    NM_001242524.1  NM_001242525.1  NM_033554.3  

    Unigene Cluster for HLA-DPA1:

    Major histocompatibility complex, class II, DP alpha 1
    Hs.347270  [show with all ESTs]
    Unigene Representative Sequence: NM_001242524
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419277(uc003ocs.2 uc021ywg.1 uc021ywh.1) ENST00000479107(uc010juk.3)
    ENST00000437811 ENST00000453337 ENST00000476642 ENST00000463066 ENST00000417724
    ENST00000428995
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    SwitchGear 3'UTR luciferase reporter plasmidHLA-DPA1 3' UTR sequence
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    OriGene qSTAR qPCR primer pairs in human, mouse for HLA-DPA1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HLA-DPA1
      QuantiTect SYBR Green Assays in human, mouse, rat HLA-DPA1
      QuantiFast Probe-based Assays in human, mouse, rat HLA-DPA1

    Additional mRNA sequence: 

    AK292709.1 BC009956.2 M27487.1 X00457.1 

    Selected DOTS entries (see all 36):

    DT.121402866  DT.95202456  DT.449635  DT.100838953  DT.95163813  DT.100830372  DT.95163821  DT.100838951 
    DT.95163812  DT.100838955  DT.100045889  DT.95163819  DT.121402704  DT.91970147  DT.95106210  DT.100855331 
    DT.121402761  DT.95163816  DT.121402712  DT.121402724  DT.121402790  DT.121402837  DT.121402842  DT.121402868 

    Selected AceView cDNA sequences (see all 699):

    BQ061344 AA512953 AA908815 NM_033554 BQ057757 CD365987 BM767502 BE765202 
    BQ642196 H66976 BU616433 AU139061 AW072359 BM996250 AW629653 BI767351 
    AI554919 BE765261 AL048563 BU616745 AA337387 AI474920 BU617866 BU616611 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    HLA-DPA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAAACTAC
    HLA-DPA1 Expression
    About this image


    HLA-DPA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Plasmacytoid Dendritic cells Peripheral Blood
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical Veins
             Umbilical tissue-derived cells (CNTO2476)
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    HLA-DPA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HLA-DPA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.347270
        Pathway & Disease-focused RT2 Profiler PCR Array including HLA-DPA1: 
              Antigen Presenting Cells in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for HLA-DPA1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DPA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-DPA1 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia H2-Pa5 histocompatibility 2, P region alpha locus   --   17 (17.98 cM) 34084672 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    58(a)
    54(a)
    many ↔ many
    many ↔ many
    GL343775.1(20845-38928)
    GL343809.1(2435-3996)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003322041 h-2 class II histocompatibility antigen, A-K alpha more 47.43(n)
    39.02(a)
      100332204  XM_002660388.3  XP_002660434.3 


    ENSEMBL Gene Tree for HLA-DPA1 (if available)
    TreeFam Gene Tree for HLA-DPA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HLA-DPA1 gene
    HLA-DRB52  HLA-DQA12  HLA-DQB12  HLA-DRA2  HLA-DRB12  HLA-DOB2  HLA-DMA2  HLA-DQB22  
    HLA-DOA2  ENSG000002489932  HLA-DMB2  HLA-DQA22  HLA-DPB12  
    Selected SIMAP similar genes for HLA-DPA1 using alignment to 79 protein entries:     DPA1_HUMAN (see all proteins) (see all similar genes):
    HLA-DRA1    HLA-DQA2    HLA-DQA1/DRA    HLA-DQA1    DQ-A1    HLA-DOA
    HLA-DRA    DQA1-0103    HLA-DPB1    HLA-DPB    HLA-DQ3    HLA-DQB2
    HLA-DQB    HLA-DQB1    HLA-D    HLQ-DQB1    HLA-DRB1    HLA-DMA

    Find genes that share paralogs with HLA-DPA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    DPA1_HUMAN, P20036: The following alleles of DPA1 are known: DPA1*01:03, DPA1*01:04, DPA1*01:05, DPA1*01:06, DPA1*01:07,
    DPA1*01:08, DPA1*01:09, DPA1*01:10, DPA1*02:01, DPA1*02:02, DPA1*02:03, DPA1*02:04, DPA1*03:01, DPA1*03:02,
    DPA1*03:03, DPA1*04:01 The sequence shown is that of DPA1*01:03


    Selected SNPs for HLA-DPA1 (see all 725)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500377971,2
    C--33031917(+) TTTTT-/CCAATA 3 -- ds50010--------
    rs2009711461,2
    C--33031918(+) TTTTC-/CAATAG 3 -- ds50010--------
    rs1131455171,2
    C--33031920(+) TTTCAG/ATAGTT 3 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs2000914121,2
    C--33031920(+) TTCAA-/GTAGTT 3 -- ds50010--------
    rs728739461,2
    C--33031934(+) AGGAGC/TTTAAA 3 -- ds50015Minor allele frequency- T:0.49WA CSA NA EA 361
    rs668822831,2
    C--33031986(+) CACTTA/CACATG 3 -- ds50016Minor allele frequency- C:0.49WA CSA NA EA 363
    rs675146921,2
    C--33031994(+) ATGTAT/CAAGAA 3 -- ds50017Minor allele frequency- C:0.49WA NA CSA EA 365
    rs733979161,2
    C--33032013(+) CATTAT/CACTTC 3 -- ds50015Minor allele frequency- C:0.24WA CSA NA EA 361
    rs1819004191,2
    --33032074(+) GTATGC/TTATAA 3 -- ds50010--------
    rs172208991,2
    C,F--33032096(+) ATTTTT/CACTTT 3 -- ds50017Minor allele frequency- C:0.46MN WA CSA NA EA 415

    HapMap Linkage Disequilibrium report for HLA-DPA1 (33032346 - 33048555 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HLA-DPA1 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731879CNV Deletion23290073
    nsv885764CNV Loss21882294
    dgv1039n67CNV Loss20364138
    nsv823649CNV Loss20364138
    nsv823645CNV Loss20364138
    dgv6827n71CNV Loss21882294
    dgv1040n67CNV Loss20364138
    nsv823646CNV Loss20364138
    esv22467CNV Loss19812545
    nsv885760CNV Loss21882294

    Locus Specific Mutation Databases (LSDB): HLA-DPA1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HLA-DPA1
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-DPA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142880    OMIM disorders: --

    3 diseases for HLA-DPA1:    
    About MalaCards
    berylliosis    acute disseminated encephalomyelitis    pre-eclampsia


    Find genes that share disorders with HLA-DPA1           About GenesLikeMe

    2 Novoseek inferred disease relationships for HLA-DPA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    celiac disease 39.7 2 7576003 (1), 1676703 (1)
    lupus erythematosus systemic 17.7 4 8154937 (2), 2323107 (1)

    Genetic Association Database (GAD): HLA-DPA1
    Human Genome Epidemiology (HuGE) Navigator: HLA-DPA1 (45 documents)

    Export disorders for HLA-DPA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HLA-DPA1 gene, integrated from 10 sources (see all 167):
    (articles sorted by number of sources associating them with HLA-DPA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes. (PubMed id 6584734)1, 2, 3 Auffray C....Strominger J.L. (Nature 1984)
    2. Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers in the Han Chinese population. (PubMed id 21274863)1, 4 Guo X....O'Brien S.J. (Hepatology 2011)
    3. Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. (PubMed id 21779181)1, 4 Gorlova O....Martin J. (PLoS Genet. 2011)
    4. Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. (PubMed id 21814517)1, 4 Noguchi E....Matsumoto K. (PLoS Genet. 2011)
    5. A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. (PubMed id 21750111)1, 4 Mbarek H....Matsuda K. (Hum. Mol. Genet. 2011)
    6. HLA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: analysis of the type 1 diabetes genetics consortium families. (PubMed id 20424227)1, 4 Varney M.D....Erlich H. (Diabetes 2010)
    7. HLA genotyping in the international Type 1 Diabetes Genetics Consortium. (PubMed id 20595243)1, 4 Mychaleckyj J.C....Erlich H.A. (Clin Trials 2010)
    8. Effect of human leukocyte antigen homozygosity on rubella vaccine-induced humoral and cell-mediated immune responses. (PubMed id 19896518)1, 4 Kennedy R.B....Poland G.A. (Hum. Immunol. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Acute disseminated encephalomyelitis: clinical features, HLA DRB1*1501, HLA DRB1*1503, HLA DQA1*0102, HLA DQB1*0602, and HLA DPA1*0301 allelic association study. (PubMed id 19722042)1, 4 Alves-Leon S.V....Quirico-Santos T. (Arq Neuropsiquiatr 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3113 HGNC: 4938 AceView: HLA-DPA1 Ensembl:ENSG00000231389 euGenes: HUgn3113
    ECgene: HLA-DPA1 Kegg: 3113 H-InvDB: HLA-DPA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HLA-DPA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HLA-DPA1 gene:
    Search GeneIP for patents involving HLA-DPA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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