Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HLA-DPA1 Gene

Aliases for HLA-DPA1 Gene

  • Major Histocompatibility Complex, Class II, DP Alpha 1 2 3 5
  • MHC Class II DP3-Alpha 3 4
  • HLA-SB Alpha Chain 3 4
  • HLA-DP1A 3 4
  • DP(W3) 3 4
  • DP(W4) 3 4
  • HLASB 3 4
  • MHC Class II HLA-DPA1 Antigen 3
  • Primed Lymphocyte Test-1 3
  • MHC Class II Antigen 3
  • MHC Class II DPA1 4
  • HLADP 3
  • PLT1 3

External Ids for HLA-DPA1 Gene

Previous HGNC Symbols for HLA-DPA1 Gene

  • HLA-DP1A

Previous GeneCards Identifiers for HLA-DPA1 Gene

  • GC06U990043
  • GC06M033029
  • GC06M033079
  • GC06M033140
  • GC06M032775

Summaries for HLA-DPA1 Gene

Entrez Gene Summary for HLA-DPA1 Gene

  • HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-DPA1 Gene

HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1) is a Protein Coding gene. Diseases associated with HLA-DPA1 include posner-schlossman syndrome and leishmaniasis. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include peptide antigen binding and MHC class II receptor activity. An important paralog of this gene is HLA-DMA.

UniProtKB/Swiss-Prot for HLA-DPA1 Gene

  • Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-DPA1 Gene

Genomics for HLA-DPA1 Gene

Regulatory Elements for HLA-DPA1 Gene

Promoters for HLA-DPA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HLA-DPA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HLA-DPA1 Gene

Chromosome:
6
Start:
33,064,569 bp from pter
End:
33,080,778 bp from pter
Size:
16,210 bases
Orientation:
Minus strand

Genomic View for HLA-DPA1 Gene

Genes around HLA-DPA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-DPA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-DPA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-DPA1 Gene

  • Protein details for HLA-DPA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20036-DPA1_HUMAN
    Recommended name:
    HLA class II histocompatibility antigen, DP alpha 1 chain
    Protein Accession:
    P20036
    Secondary Accessions:
    • A9YWH7
    • B9UKH4
    • O19722
    • O46883
    • P01905
    • P79554
    • Q2Q060
    • Q2Q061
    • Q5EY03
    • Q5STP1
    • Q6DQK4
    • Q9BCQ1
    • Q9TPX3
    • Q9XS10

    Protein attributes for HLA-DPA1 Gene

    Size:
    260 amino acids
    Molecular mass:
    29381 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.
    SequenceCaution:
    • Sequence=AAC64233.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAD42927.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HLA-DPA1 Gene

neXtProt entry for HLA-DPA1 Gene

Proteomics data for HLA-DPA1 Gene at MOPED

Post-translational modifications for HLA-DPA1 Gene

  • Glycosylation at Asn 109 and Asn 149
  • Modification sites at PhosphoSitePlus

Other Protein References for HLA-DPA1 Gene

Antibody Products

No data available for DME Specific Peptides for HLA-DPA1 Gene

Domains & Families for HLA-DPA1 Gene

Graphical View of Domain Structure for InterPro Entry

P20036

UniProtKB/Swiss-Prot:

DPA1_HUMAN :
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Belongs to the MHC class II family.
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Family:
  • Belongs to the MHC class II family.
genes like me logo Genes that share domains with HLA-DPA1: view

Function for HLA-DPA1 Gene

Molecular function for HLA-DPA1 Gene

GENATLAS Biochemistry:
HLA-DP,alpha chain
UniProtKB/Swiss-Prot Function:
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
genes like me logo Genes that share phenotypes with HLA-DPA1: view

Animal Model Products

CRISPR Products

miRNA for HLA-DPA1 Gene

miRTarBase miRNAs that target HLA-DPA1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-DPA1 Gene

Localization for HLA-DPA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-DPA1 Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HLA-DPA1 Gene COMPARTMENTS Subcellular localization image for HLA-DPA1 gene
Compartment Confidence
plasma membrane 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HLA-DPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010008 endosome membrane IEA --
GO:0012507 ER to Golgi transport vesicle membrane TAS --
GO:0032588 trans-Golgi network membrane TAS --
GO:0042613 MHC class II protein complex IEA,IDA 20356827
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with HLA-DPA1: view

Pathways & Interactions for HLA-DPA1 Gene

genes like me logo Genes that share pathways with HLA-DPA1: view

Interacting Proteins for HLA-DPA1 Gene

Gene Ontology (GO) - Biological Process for HLA-DPA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0019882 antigen processing and presentation IEA --
GO:0050870 positive regulation of T cell activation IMP 20356827
genes like me logo Genes that share ontologies with HLA-DPA1: view

No data available for SIGNOR curated interactions for HLA-DPA1 Gene

Drugs & Compounds for HLA-DPA1 Gene

(1) Drugs for HLA-DPA1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Peginterferon alfa-2b Approved Pharma 299

(1) Additional Compounds for HLA-DPA1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HLA-DPA1: view

Transcripts for HLA-DPA1 Gene

Unigene Clusters for HLA-DPA1 Gene

Major histocompatibility complex, class II, DP alpha 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-DPA1 Gene

No ASD Table

Relevant External Links for HLA-DPA1 Gene

GeneLoc Exon Structure for
HLA-DPA1
ECgene alternative splicing isoforms for
HLA-DPA1

Expression for HLA-DPA1 Gene

mRNA expression in normal human tissues for HLA-DPA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-DPA1 Gene

This gene is overexpressed in Whole Blood (x4.2) and Spleen (x4.0).

Protein differential expression in normal tissues from HIPED for HLA-DPA1 Gene

This gene is overexpressed in Blymphocyte (12.0), Lymph node (10.2), and Lung (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HLA-DPA1 Gene



SOURCE GeneReport for Unigene cluster for HLA-DPA1 Gene Hs.347270

genes like me logo Genes that share expression patterns with HLA-DPA1: view

Protein tissue co-expression partners for HLA-DPA1 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HLA-DPA1 Gene

Orthologs for HLA-DPA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HLA-DPA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PATR-DPA1 35
  • 97.95 (n)
  • 95.77 (a)
PATR-DPA1 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BOLA-DYA 36
  • 56 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii LOC100332204 35
  • 47.43 (n)
  • 39.02 (a)
si:busm1-160c18.1 36
  • 30 (a)
ManyToMany
Species with no ortholog for HLA-DPA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HLA-DPA1 Gene

ENSEMBL:
Gene Tree for HLA-DPA1 (if available)
TreeFam:
Gene Tree for HLA-DPA1 (if available)

Paralogs for HLA-DPA1 Gene

genes like me logo Genes that share paralogs with HLA-DPA1: view

Variants for HLA-DPA1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DPA1 Gene

P20036-DPA1_HUMAN
The following alleles of DPA1 are known: DPA1*01:03, DPA1*01:04, DPA1*01:05, DPA1*01:06, DPA1*01:07, DPA1*01:08, DPA1*01:09, DPA1*01:10, DPA1*02:01, DPA1*02:02, DPA1*02:03, DPA1*02:04, DPA1*03:01, DPA1*03:02, DPA1*03:03, DPA1*04:01 The sequence shown is that of DPA1*01:03.

Sequence variations from dbSNP and Humsavar for HLA-DPA1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1126533 - 33,069,863(-) ATGCC(A/C/G/T)CGTTT reference, missense
rs1126534 - 33,069,862(-) TGCCG(C/T)GTTTG reference, missense
rs2308911 - 33,069,803(-) ATGAG(A/C)TGTTC reference, missense
rs1042178 - 33,069,745(-) TGGCC(A/G)AGCCT reference, missense
rs2308917 - 33,069,697(-) TATAT(C/T)GAACA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HLA-DPA1 Gene

Variant ID Type Subtype PubMed ID
nsv819387 CNV Loss 19587683
nsv885754 CNV Gain 21882294
esv22467 CNV Loss 19812545
dgv1039n67 CNV Loss 20364138
esv2545651 CNV Loss 19546169
nsv823641 CNV Loss 20364138
dgv6826n71 CNV Loss 21882294
dgv6827n71 CNV Loss 21882294
nsv885759 CNV Loss 21882294
nsv885760 CNV Loss 21882294
nsv823645 CNV Loss 20364138
nsv885763 CNV Loss 21882294
nsv823646 CNV Loss 20364138
esv1006913 CNV Gain 20482838
nsv823647 CNV Loss 20364138
esv2731879 CNV Deletion 23290073
nsv823648 CNV Loss 20364138
nsv823649 CNV Loss 20364138
nsv885764 CNV Loss 21882294
nsv823650 CNV Loss 20364138
dgv1040n67 CNV Loss 20364138

Variation tolerance for HLA-DPA1 Gene

Residual Variation Intolerance Score: 96.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.70; 98.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HLA-DPA1 Gene

HapMap Linkage Disequilibrium report
HLA-DPA1

Disorders for HLA-DPA1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for HLA-DPA1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
posner-schlossman syndrome
  • glaucomatocyclitic crisis
leishmaniasis
  • cutaneous leishmaniasis
berylliosis
  • beryllium poisoning
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HLA-DPA1

Genetic Association Database (GAD)
HLA-DPA1
Human Genome Epidemiology (HuGE) Navigator
HLA-DPA1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HLA-DPA1
genes like me logo Genes that share disorders with HLA-DPA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HLA-DPA1 Gene

Publications for HLA-DPA1 Gene

  1. Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes. (PMID: 6584734) Auffray C. … Strominger J.L. (Nature 1984) 2 3 4 67
  2. An ancient balanced polymorphism in a regulatory region of human major histocompatibility complex is retained in Chinese minorities but lost worldwide. (PMID: 16465617) Liu X. … Xu A. (Am. J. Hum. Genet. 2006) 3 23
  3. The nucleotide sequence of two new DP alleles, DPA1*02015 and DPB1*8401, identified in a Chinese subject. (PMID: 10958363) McTernan C.L. … Barnett A.H. (Tissue Antigens 2000) 3 23
  4. [Association of HLA-DPA1 and -DPB1 polymorphisms with Posner-Schlossman syndrome among southern Chinese Han population]. (PMID: 25863099) Zhao J. … Deng Z. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for HLA-DPA1 Gene

Sources for HLA-DPA1 Gene

Back to Top

Content