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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLA-DPA1 Gene

protein-coding   GIFtS: 61
GCID: GC06M033032

Major Histocompatibility Complex, Class II, DP Alpha 1


(Previous symbol: HLA-DP1A)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Major Histocompatibility Complex, Class II, DP Alpha 11 2     HLADP2 5
HLA-DP1A1 2 3     PLT12
DP(W3)2 3     HLA Class II Histocompatibility Antigen, DP Alpha 1 Chain2
DP(W4)2 3     MHC Class II Antigen2
HLASB2 3     MHC Class II HLA-DPA1 Antigen2
HLA-SB Alpha Chain2 3     Primed Lymphocyte Test-12
MHC Class II DP3-Alpha2 3     MHC Class II DPA13

External Ids:    HGNC: 49381   Entrez Gene: 31132   Ensembl: ENSG000002313897   OMIM: 1428805   UniProtKB: P200363   

Export aliases for HLA-DPA1 gene to outside databases

Previous GC identifers: GC06U990043 GC06M033029 GC06M033079 GC06M033140 GC06M032775


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HLA-DPA1 Gene:
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of
an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune
system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen
presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa
and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular
domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha
chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up
to 4 different molecules. (provided by RefSeq, Jul 2008)

GeneCards Summary for HLA-DPA1 Gene: 
HLA-DPA1 (major histocompatibility complex, class II, DP alpha 1) is a protein-coding gene. Diseases associated with HLA-DPA1 include berylliosis, and herpetic keratitis, and among its related super-pathways are Allograft rejection and Costimulation by the CD28 family. GO annotations related to this gene include MHC class II receptor activity. An important paralog of this gene is HLA-DRB5.

UniProtKB/Swiss-Prot: DPA1_HUMAN, P20036
Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
(class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the
regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
efficient peptide loading




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLA-DPA1 gene promoter:
         GR   NRSF form 1   p300   CUTL1   MIF-1   NRSF form 2   PPAR-alpha   STAT3   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHLA-DPA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HLA-DPA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

HLA-DPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-DPA1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M033032:  view genomic region     (about GC identifiers)

Start:
33,032,346 bp from pter      End:
33,048,555 bp from pter
Size:
16,210 bases      Orientation:
minus strand

6/7 alternative locations (see all 7):
Chr6-,NT_167247 4,369,219-4,385,416      Chr6-,NT_167244 4,319,165-4,335,362      Chr6-,NT_167248 4,264,797-4,281,012     
Chr6-,NT_167245 4,313,685-4,329,894      Chr6-,NT_167249 4,512,850-4,529,059      Chr6-,NT_167246 4,489,886-4,506,101     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DPA1_HUMAN, P20036 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen, DP alpha 1 chain precursor  
Size: 260 amino acids; 29381 Da
Subunit: Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic
reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as
invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74
undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II
molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and
facilitate the binding of antigenic peptides
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane;
Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane
protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic
pathway until it reaches the cell membrane for antigen presentation
Sequence caution: Sequence=AAC64233.1; Type=Erroneous gene model prediction; Sequence=AAD42927.1; Type=Erroneous
gene model prediction;
1 PDB 3D structure from and Proteopedia for HLA-DPA1:
3LQZ (3D)    
Secondary accessions: A9YWH7 B9UKH4 O19722 O46883 P01905 P79554 Q2Q060 Q2Q061 Q5EY03 Q5STP1
Q6DQK4 Q9BCQ1 Q9TPX3 Q9XS10

Explore the universe of human proteins at neXtProt for HLA-DPA1: NX_P20036

Explore proteomics data for HLA-DPA1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P20036

  • HLA-DPA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HLA-DPA1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001229453.1  NP_001229454.1  NP_291032.2  

    ENSEMBL proteins: 
     ENSP00000393566   ENSP00000405500   ENSP00000390929   ENSP00000398134   ENSP00000402872  
    Reactome Protein details: P20036
    Human Recombinant Protein Products for HLA-DPA1: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for HLA-DPA1
    OriGene Custom MassSpec 
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    GenScript Custom Purified and Recombinant Proteins Services for HLA-DPA1
    Novus Biologicals HLA-DPA1 Protein
    Novus Biologicals HLA-DPA1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005765lysosomal membrane TAS--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane NAS2461352
    GO:0010008endosome membrane IEA--

    HLA-DPA1 for ontologies           About GeneDecksing



    HLA-DPA1 Antibody Products: 
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    Abcam antibodies for HLA-DPA1
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    LSBio Antibodies in human, mouse, rat for HLA-DPA1 

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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HLA: Histocompatibility complex
    C1SET: Immunoglobulin superfamily / C1-set domain containing

    5/7 InterPro protein domains (see all 7):
     IPR001003 MHC_II_a_N
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR014745 MHC_II_a/b_N
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry P20036

    ProtoNet protein and cluster: P20036

    2 Blocks protein domains:
    IPB001003 MHC Class II alpha chain
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: DPA1_HUMAN, P20036
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    HLA-DPA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DPA1_HUMAN, P20036
    Function: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC)
    and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates
    peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation
    of proteins that access the endocytic route, where they are processed by lysosomal proteases and other
    hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation
    via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous.
    As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also
    contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from
    endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with
    MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as
    epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI
    tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of
    an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry
    of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential
    degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP
    (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to
    the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high
    affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell
    membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
    Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the
    regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and
    efficient peptide loading

         Genatlas biochemistry entry for HLA-DPA1:
    HLA-DP,alpha chain

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0032395MHC class II receptor activity NAS2461352
         
    HLA-DPA1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HLA-DPA1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HLA-DPA1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HLA-DPA1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HLA-DPA1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-DPA1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate HLA-DPA1:
    hsa-miR-877* hsa-miR-631 hsa-miR-3661
    SwitchGear 3'UTR luciferase reporter plasmidHLA-DPA1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HLA-DPA1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-DPA1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HLA-DPA1
    Sirion Biotech Customized adenovirus for overexpression of HLA-DPA1

    Clone
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    GenScript: all cDNA clones in your preferred vector: HLA-DPA1 (NM_033554)
    Sino Biological Human cDNA Clone for HLA-DPA1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-DPA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DPA1
    Sirion Biotech Customized lentivirus for stable overexpression of HLA-DPA1 
                         Customized lentivirus expression plasmids for stable overexpression of HLA-DPA1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HLA-DPA1
    Search LifeMap BioReagents cell lines for HLA-DPA1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DPA1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HLA-DPA1 About   (see all 29)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Allograft rejection
    Allograft rejection0.69
    Intestinal immune network for IgA production0.42
    Type I diabetes mellitus0.69
    THC Differentiation Pathway0.37
    Graft-versus-host disease0.65
    Antigen processing and presentation0.37
    Autoimmune thyroid disease0.62
    CTL Mediated Apoptosis0.36
    2CD28 co-stimulation
    Costimulation by the CD28 family0.41
    CTLA4 Signaling0.31
    3Translocation of ZAP-70 to Immunological synapse
    Translocation of ZAP-70 to Immunological synapse0.85
    PD-1 signaling0.77
    Phosphorylation of CD3 and TCR zeta chains0.85
    Generation of second messenger molecules0.64
    4ICos-ICosL Pathway in T-Helper Cell
    ICos-ICosL Pathway in T-Helper Cell0.66
    Calcium Mediated T-Cell Apoptosis0.31
    CD28 Signaling in T-Helper Cell0.66
    5Interferon Signaling
    Interferon Signaling0.61
    Interferon gamma signaling0.41
    Cytokine Signaling in Immune system0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 EMD Millipore Pathways for HLA-DPA1 (see all 6)
        Immune response Antigen presentation by MHC class II
    G-protein signaling N-RAS regulation pathway
    Immune response IL-22 signaling pathway
    Immune response NFAT in immune response
    Immune response ICOS pathway in T-helper cell

    5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HLA-DPA1 (see all 12)
        THC Differentiation Pathway
    Calcium Mediated T-Cell Apoptosis
    IL-4 Pathway
    ICos-ICosL Pathway in T-Helper Cell
    CDC42 Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for HLA-DPA1 (see all 6)
        Immune response Antigen presentation by MHC class II
    Immune response ICOS pathway in T-helper cell
    Immune response T cell receptor signaling pathway
    Immune response IL-22 signaling pathway
    G-protein signaling N-RAS regulation pathway

    1 Sino Biological Pathway for HLA-DPA1 
        NF-kB (NFkB) Pathway

    5/13        Reactome Pathways for HLA-DPA1 (see all 13)
        Interferon gamma signaling
    Costimulation by the CD28 family
    Cytokine Signaling in Immune system
    Adaptive Immune System
    Translocation of ZAP-70 to Immunological synapse


    5/21         Kegg Pathways  (Kegg details for HLA-DPA1) (see all 21):
        Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Intestinal immune network for IgA production
    Type I diabetes mellitus


    HLA-DPA1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HLA-DPA1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/8 Interacting proteins for HLA-DPA1 (P200362, 3 ENSP000003935664) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD74P042332, 3, ENSP000000095304MINT-72790 I2D: score=2 STRING: ENSP00000009530
    HLA-DPB1P044403, ENSP000004081464I2D: score=1 STRING: ENSP00000408146
    ENSG00000215048P044403I2D: score=1 
    ENSG00000226826P044403I2D: score=1 
    ENSG00000230763P044403I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002504antigen processing and presentation of peptide or polysaccharide antigen via MHC class II ----
    GO:0006955immune response NAS2461352
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0019882antigen processing and presentation ----
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--

    HLA-DPA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HLA-DPA1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HLA-DPA1 (DPA1)

    1 Novoseek inferred chemical compound relationship for HLA-DPA1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dpa 1 95 5 9154456 (3), 8225437 (1)

    Search CenterWatch for drugs/clinical trials and news about HLA-DPA1 / DPA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HLA-DPA1 gene (3 alternative transcripts): 
    NM_001242524.1  NM_001242525.1  NM_033554.3  

    Unigene Cluster for HLA-DPA1:

    Major histocompatibility complex, class II, DP alpha 1
    Hs.347270  [show with all ESTs]
    Unigene Representative Sequence: NM_001242524
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419277(uc003ocs.2 uc021ywg.1 uc021ywh.1) ENST00000479107(uc010juk.3)
    ENST00000437811 ENST00000453337 ENST00000476642 ENST00000463066 ENST00000417724
    ENST00000428995
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    SwitchGear 3'UTR luciferase reporter plasmidHLA-DPA1 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-DPA1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DPA1
    Sirion Biotech Customized lentivirus for stable overexpression of HLA-DPA1 
                         Customized lentivirus expression plasmids for stable overexpression of HLA-DPA1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DPA1
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    Additional mRNA sequence: 

    AK292709.1 BC009956.2 M27487.1 X00457.1 

    24/36 DOTS entries (see all 36):

    DT.121402866  DT.95202456  DT.449635  DT.100838953  DT.95163813  DT.100830372  DT.95163821  DT.100838951 
    DT.95163812  DT.100838955  DT.100045889  DT.95163819  DT.121402704  DT.91970147  DT.95106210  DT.100855331 
    DT.121402761  DT.95163816  DT.121402712  DT.121402724  DT.121402790  DT.121402837  DT.121402842  DT.121402868 

    24/699 AceView cDNA sequences (see all 699):

    AA662151 AA701526 BI766898 AW339073 CA425549 BU782589 BQ270512 CD367037 
    BQ446041 CA426210 BU617249 AA337387 BU616611 BF725429 BQ062257 BM996250 
    CA308455 BQ056978 BI769913 AU139061 BX363746 BQ890384 H66976 BG152603 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HLA-DPA1 expression in normal human tissues (normalized intensities)      HLA-DPA1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAAACTAC
    HLA-DPA1 Expression
    About this image


    HLA-DPA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 14 entries
             Plasmacytoid Dendritic cells Peripheral Blood
             Fetal Liver CD36+ Cells   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 4 entries
             Umbilical tissue-derived cells (CNTO2476)
             Cord Blood Natural Killer Cells (CD56+)   
     
     Mesenchymal Stem Cells (Muscoskeletal System)    fully expand to see all 3 entries
             Human Mesenchymal Stem Cells (hMSC)-1   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Fetal Liver CD36+ Cells   
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus

    See HLA-DPA1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HLA-DPA1

    SOURCE GeneReport for Unigene cluster: Hs.347270
        SABiosciences Expression via Pathway-Focused PCR Array including HLA-DPA1: 
              Antigen Presenting Cells in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DPA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-DPA1 gene from 3/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia H2-Pa5 histocompatibility 2, P region alpha locus   --   17 (17.98 cM) 34084672 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    25(a)
    possible ortholog
    GL344367.1(8520-11306)
    zebrafish
    (Danio rerio)
    Actinopterygii si:busm1-266f07.26
    si:busm1-48c11.36
    (see all 10)
    si:busm1-48c11.3
    (see all 10)
    31(a)
    30(a)
    (see all 10)
    many ↔ many
    many ↔ many
    (see all 10)
    8(37539907-37543263)
    8(36283500-36286998)


    ENSEMBL Gene Tree for HLA-DPA1 (if available)
    TreeFam Gene Tree for HLA-DPA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HLA-DPA1 gene
    HLA-DRB52  HLA-DQA12  HLA-DQB12  HLA-DRA2  HLA-DRB12  HLA-DOB2  HLA-DMA2  HLA-DQB22  
    HLA-DOA2  ENSG000002489932  HLA-DMB2  HLA-DQA22  HLA-DPB12  
    18/30 SIMAP similar genes for HLA-DPA1 using alignment to 78 protein entries:     DPA1_HUMAN (see all proteins) (see all similar genes):
    HLA-DRA1    HLA-DQA2    HLA-DQA1/DRA    HLA-DQA1    DQ-A1    HLA-DOA
    HLA-DRA    DQA1-0103    HLA-DPB1    HLA-DPB    HLA-DQ3    HLA-DQB2
    HLA-DQB1    HLA-DQB    HLA-D    HLQ-DQB1    HLA-DRB1    HLA-DR

    HLA-DPA1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: DPA1_HUMAN, P20036
    Polymorphism: The following alleles of DPA1 are known: DPA1*01:03, DPA1*01:04, DPA1*01:05, DPA1*01:06, DPA1*01:07,
    DPA1*01:08, DPA1*01:09, DPA1*01:10, DPA1*02:01, DPA1*02:02, DPA1*02:03, DPA1*02:04, DPA1*03:01, DPA1*03:02,
    DPA1*03:03, DPA1*04:01 The sequence shown is that of DPA1*01:03


    10/725 SNPs in HLA-DPA1 are shown (see all 725)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0588504
    ----see VAR_0588502 M Q mis40--------
    VAR_0588414
    ----see VAR_0588412 L A mis40--------
    VAR_0588444
    ----see VAR_0588442 T A mis40--------
    VAR_0588324
    ----see VAR_0588322 A M mis40--------
    rs1500377971,2
    C--33031917(+) TTTTT-/CCAATA 3 -- ds50010--------
    rs2009711461,2
    C--33031918(+) TTTTC-/CAATAG 3 -- ds50010--------
    rs1131455171,2
    C--33031920(+) TTTCAG/ATAGTT 3 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs2000914121,2
    C--33031920(+) TTCAA-/GTAGTT 3 -- ds50010--------
    rs728739461,2
    C--33031934(+) AGGAGC/TTTAAA 3 -- ds50015Minor allele frequency- T:0.49WA CSA NA EA 361
    rs668822831,2
    C--33031986(+) CACTTA/CACATG 3 -- ds50016Minor allele frequency- C:0.49WA CSA NA EA 363

    HapMap Linkage Disequilibrium report for HLA-DPA1 (33032346 - 33048555 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for HLA-DPA1 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2731879CNV Deletion23290073
    nsv885764CNV Loss21882294
    dgv1039n67CNV Loss20364138
    nsv823649CNV Loss20364138
    nsv823645CNV Loss20364138
    dgv6827n71CNV Loss21882294
    dgv1040n67CNV Loss20364138
    nsv823646CNV Loss20364138
    esv22467CNV Loss19812545
    nsv885760CNV Loss21882294


    Locus Specific Mutation Databases (LSDB): HLA-DPA1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HLA-DPA1
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-DPA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142880    OMIM disorders: --

    20/52 diseases for HLA-DPA1 (see all 52):    About MalaCards
    berylliosis    herpetic keratitis    acute disseminated encephalomyelitis    intrahepatic cholestasis of pregnancy
    keratitis    severe pre-eclampsia    intrahepatic cholestasis    cutaneous leishmaniasis
    pre-eclampsia    thrombasthenia    eclampsia    glanzmann's thrombasthenia
    rubella    cholestasis    celiac disease    t cell deficiency
    leishmaniasis    schistosomiasis    toxoplasmosis    encephalomyelitis


    HLA-DPA1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for HLA-DPA1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    celiac disease 39.7 2 7576003 (1), 1676703 (1)
    lupus erythematosus systemic 17.7 4 8154937 (2), 2323107 (1)

    Genetic Association Database (GAD): HLA-DPA1
    Human Genome Epidemiology (HuGE) Navigator: HLA-DPA1 (45 documents)

    Export disorders for HLA-DPA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HLA-DPA1 gene, integrated from 9 sources (see all 162):
    (articles sorted by number of sources associating them with HLA-DPA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes. (PubMed id 6584734)1, 2, 3 Auffray C....Strominger J.L. (1984)
    2. Strong influence of human leukocyte antigen (HLA)-DP gene variants on development of persistent chronic hepatitis B virus carriers i n the Han Chinese population. (PubMed id 21274863)1, 4 Guo X....O'Brien S.J. (2011)
    3. Identification of novel genetic markers associated wit h clinical phenotypes of systemic sclerosis through a genome-wide association st rategy. (PubMed id 21779181)1, 4 Gorlova O....Martin J. (2011)
    4. Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. (PubMed id 21814517)1, 4 Noguchi E....Matsumoto K. (2011)
    5. A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. (PubMed id 21750111)1, 4 Mbarek H....Matsuda K. (2011)
    6. HLA DPA1, DPB1 alleles and haplotypes contribute to t he risk associated with type 1 diabetes: analysis of the type 1 diabetes geneti cs consortium families. (PubMed id 20424227)1, 4 Varney M.D....Erlich H. (2010)
    7. HLA genotyping in the international Type 1 Diabetes G enetics Consortium. (PubMed id 20595243)1, 4 Mychaleckyj J.C....Erlich H.A. (2010)
    8. Effect of human leukocyte antigen homozygosity on rub ella vaccine-induced humoral and cell-mediated immune responses. (PubMed id 19896518)1, 4 Kennedy R.B....Poland G.A. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    10. Acute disseminated encephalomyelitis: clinical featur es, HLA DRB1*1501, HLA DRB1*1503, HLA DQA1*0102, HLA DQB1*0602, and HLA DPA1*03 01 allelic association study. (PubMed id 19722042)1, 4 Alves-Leon S.V....Quirico-Santos T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3113 HGNC: 4938 AceView: HLA-DPA1 Ensembl:ENSG00000231389 euGenes: HUgn3113
    ECgene: HLA-DPA1 Kegg: 3113 H-InvDB: HLA-DPA1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HLA-DPA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HLA-DPA1 gene:
    Search GeneIP for patents involving HLA-DPA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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