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Aliases for HLA-DOB Gene

Aliases for HLA-DOB Gene

  • Major Histocompatibility Complex, Class II, DO Beta 2 3
  • MHC Class II Antigen DOB 3 4
  • DOB 3

External Ids for HLA-DOB Gene

Previous GeneCards Identifiers for HLA-DOB Gene

  • GC06M032777
  • GC06M032551
  • GC06M032827
  • GC06M032888
  • GC06M032523

Summaries for HLA-DOB Gene

Entrez Gene Summary for HLA-DOB Gene

  • HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-DOB Gene

HLA-DOB (Major Histocompatibility Complex, Class II, DO Beta) is a Protein Coding gene. Among its related pathways are Immune System and GPCR Pathway. GO annotations related to this gene include MHC class II protein complex binding and MHC class II receptor activity. An important paralog of this gene is HLA-DMA.

UniProtKB/Swiss-Prot for HLA-DOB Gene

  • Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM

Gene Wiki entry for HLA-DOB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-DOB Gene

Genomics for HLA-DOB Gene

Regulatory Elements for HLA-DOB Gene

Genomic Location for HLA-DOB Gene

Chromosome:
6
Start:
32,812,763 bp from pter
End:
32,817,048 bp from pter
Size:
4,286 bases
Orientation:
Minus strand

Genomic View for HLA-DOB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HLA-DOB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-DOB Gene

  • Protein details for HLA-DOB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13765-DOB_HUMAN
    Recommended name:
    HLA class II histocompatibility antigen, DO beta chain
    Protein Accession:
    P13765
    Secondary Accessions:
    • B0V0Y0
    • Q29746
    • Q29825
    • Q6FHC2

    Protein attributes for HLA-DOB Gene

    Size:
    273 amino acids
    Molecular mass:
    30822 Da
    Quaternary structure:
    • Heterodimer of an alpha chain (DOA) and a beta chain (DOB). Forms a heterotetrameric complex with an HLA-DM molecule during intracellular transport in endosomal/lysosomal compartments in B-cells

    Three dimensional structures from OCA and Proteopedia for HLA-DOB Gene

neXtProt entry for HLA-DOB Gene

Proteomics data for HLA-DOB Gene at MOPED

Post-translational modifications for HLA-DOB Gene

  • Glycosylation at Asn 45
  • Modification sites at PhosphoSitePlus

Other Protein References for HLA-DOB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HLA-DOB Gene

Domains & Families for HLA-DOB Gene

Gene Families for HLA-DOB Gene

Graphical View of Domain Structure for InterPro Entry

P13765

UniProtKB/Swiss-Prot:

DOB_HUMAN :
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Belongs to the MHC class II family.
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Family:
  • Belongs to the MHC class II family.
genes like me logo Genes that share domains with HLA-DOB: view

Function for HLA-DOB Gene

Molecular function for HLA-DOB Gene

GENATLAS Biochemistry:
HLA-DO,alpha chain,expressed in B cell lysosomes,heterodimerizing with HLA-DNA to form HLA-DO,acting as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules
UniProtKB/Swiss-Prot Function:
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM

Gene Ontology (GO) - Molecular Function for HLA-DOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0023026 MHC class II protein complex binding IDA 22733780
GO:0032395 MHC class II receptor activity TAS 2998758
genes like me logo Genes that share ontologies with HLA-DOB: view
genes like me logo Genes that share phenotypes with HLA-DOB: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-DOB Gene

Localization for HLA-DOB Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-DOB Gene

Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.

Gene Ontology (GO) - Cellular Components for HLA-DOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005764 lysosome IDA 8890155
GO:0005765 lysosomal membrane TAS --
GO:0010008 endosome membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with HLA-DOB: view

No data available for Subcellular locations from COMPARTMENTS for HLA-DOB Gene

Pathways & Interactions for HLA-DOB Gene

genes like me logo Genes that share pathways with HLA-DOB: view

Interacting Proteins for HLA-DOB Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000390020%0d%0a9606.ENSP00000229829%0d%0a9606.ENSP00000339398%0d%0a9606.ENSP00000364076%0d%0a9606.ENSP00000378786%0d%0a9606.ENSP00000393566%0d%0a
Selected Interacting proteins: P13765-DOB_HUMAN ENSP00000390020 for HLA-DOB Gene via I2D STRING

Gene Ontology (GO) - Biological Process for HLA-DOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II --
GO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II IDA 22733780
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 2998758
GO:0019882 antigen processing and presentation --
genes like me logo Genes that share ontologies with HLA-DOB: view

No data available for SIGNOR curated interactions for HLA-DOB Gene

Drugs & Compounds for HLA-DOB Gene

No Compound Related Data Available

Transcripts for HLA-DOB Gene

mRNA/cDNA for HLA-DOB Gene

Unigene Clusters for HLA-DOB Gene

Major histocompatibility complex, class II, DO beta:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HLA-DOB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-DOB Gene

No ASD Table

Relevant External Links for HLA-DOB Gene

GeneLoc Exon Structure for
HLA-DOB
ECgene alternative splicing isoforms for
HLA-DOB

Expression for HLA-DOB Gene

mRNA expression in normal human tissues for HLA-DOB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-DOB Gene

This gene is overexpressed in Spleen (x11.7), Whole Blood (x5.5), and Small Intestine - Terminal Ileum (x4.7).

Protein differential expression in normal tissues from HIPED for HLA-DOB Gene

This gene is overexpressed in Blymphocyte (37.3), Lymph node (14.4), and Peripheral blood mononuclear cells (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HLA-DOB Gene



SOURCE GeneReport for Unigene cluster for HLA-DOB Gene Hs.1802

genes like me logo Genes that share expression patterns with HLA-DOB: view

Protein tissue co-expression partners for HLA-DOB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HLA-DOB Gene

Orthologs for HLA-DOB Gene

This gene was present in the common ancestor of mammals.

Orthologs for HLA-DOB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BOLA-DOB 35
  • 80.99 (n)
  • 75.19 (a)
BOLA-DOB 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLA-DOB 35
  • 86.67 (n)
  • 84.81 (a)
DLA-DOB 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia H2-Ob 35
  • 81.11 (n)
  • 75.56 (a)
H2-Ob 16
H2-Ob 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PATR-DOB 35
  • 99.51 (n)
  • 98.9 (a)
PATR-DOB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RT1-DOb 35
  • 79.75 (n)
  • 74.81 (a)
oppossum
(Monodelphis domestica)
Mammalia HLA-DOB 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
ManyToMany
Species with no ortholog for HLA-DOB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HLA-DOB Gene

ENSEMBL:
Gene Tree for HLA-DOB (if available)
TreeFam:
Gene Tree for HLA-DOB (if available)

Paralogs for HLA-DOB Gene

genes like me logo Genes that share paralogs with HLA-DOB: view

Variants for HLA-DOB Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DOB Gene

P13765-DOB_HUMAN
The following alleles of DOB are known: DOB*01:01, DOB*01:02, DOB*01:03 and DOB*01:04. The sequence shown is that of DOB*01:01

Sequence variations from dbSNP and Humsavar for HLA-DOB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs141132227 untested, untested 32,814,359(+) GTGAT(C/T)GACAA missense, reference
rs267600978 untested, untested 32,814,511(+) TATCC(C/T)CTGGA missense, reference
VAR_016743 -
VAR_016744 -
VAR_016745 -

Structural Variations from Database of Genomic Variants (DGV) for HLA-DOB Gene

Variant ID Type Subtype PubMed ID
nsv511120 CNV Complex 20534489
nsv510024 CNV Loss 20534489

Variation tolerance for HLA-DOB Gene

Residual Variation Intolerance Score: 62.03% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.50; 77.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HLA-DOB Gene

HapMap Linkage Disequilibrium report
HLA-DOB

Disorders for HLA-DOB Gene

Relevant External Links for HLA-DOB

Genetic Association Database (GAD)
HLA-DOB
Human Genome Epidemiology (HuGE) Navigator
HLA-DOB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HLA-DOB
genes like me logo Genes that share disorders with HLA-DOB: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HLA-DOB Gene

Publications for HLA-DOB Gene

  1. Detection of aberrant transcription of major histocompatibility complex class II antigen presentation genes in chronic lymphocytic leukaemia identifies HLA-DOA mRNA as a prognostic factor for survival. (PMID: 19245431) Souwer Y. … Marieke van Ham S. (Br. J. Haematol. 2009) 23 67
  2. A DOB allele encoding an amino acid substitution (Phe62Ser) resulting in a Dombrock null phenotype. (PMID: 17655578) Westhoff C. … Reid M.E. (Transfusion 2007) 23 67
  3. Dombrock gene analysis in Brazilian people reveals novel alleles. (PMID: 16756606) Baleotti W. … Castilho L. (Vox Sang. 2006) 23 67
  4. Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation. (PMID: 15265882) Fallas J.L. … Denzin L.K. (J. Immunol. 2004) 23 67
  5. Class II transactivator is required for maximal expression of HLA-DOB in B cells. (PMID: 11823510) Nagarajan U.M. … Boss J.M. (J. Immunol. 2002) 23 67

Products for HLA-DOB Gene

Sources for HLA-DOB Gene

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