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Aliases for HLA-DOB Gene

Aliases for HLA-DOB Gene

  • Major Histocompatibility Complex, Class II, DO Beta 2 3 5
  • MHC Class II Antigen DOB 3 4
  • DOB 3

External Ids for HLA-DOB Gene

Previous GeneCards Identifiers for HLA-DOB Gene

  • GC06M032777
  • GC06M032551
  • GC06M032827
  • GC06M032888
  • GC06M032523

Summaries for HLA-DOB Gene

Entrez Gene Summary for HLA-DOB Gene

  • HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-DOB Gene

HLA-DOB (Major Histocompatibility Complex, Class II, DO Beta) is a Protein Coding gene. Among its related pathways are CTLA4 Signaling and HTLV-I infection. GO annotations related to this gene include MHC class II protein complex binding and MHC class II receptor activity. An important paralog of this gene is HLA-DMA.

UniProtKB/Swiss-Prot for HLA-DOB Gene

  • Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

Gene Wiki entry for HLA-DOB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-DOB Gene

Genomics for HLA-DOB Gene

Regulatory Elements for HLA-DOB Gene

Enhancers for HLA-DOB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HLA-DOB on UCSC Golden Path with GeneCards custom track

Promoters for HLA-DOB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HLA-DOB on UCSC Golden Path with GeneCards custom track

Genomic Location for HLA-DOB Gene

Chromosome:
6
Start:
32,812,763 bp from pter
End:
32,817,048 bp from pter
Size:
4,286 bases
Orientation:
Minus strand

Genomic View for HLA-DOB Gene

Genes around HLA-DOB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-DOB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-DOB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-DOB Gene

  • Protein details for HLA-DOB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13765-DOB_HUMAN
    Recommended name:
    HLA class II histocompatibility antigen, DO beta chain
    Protein Accession:
    P13765
    Secondary Accessions:
    • B0V0Y0
    • Q29746
    • Q29825
    • Q6FHC2

    Protein attributes for HLA-DOB Gene

    Size:
    273 amino acids
    Molecular mass:
    30822 Da
    Quaternary structure:
    • Heterodimer of an alpha chain (DOA) and a beta chain (DOB). Forms a heterotetrameric complex with an HLA-DM molecule during intracellular transport in endosomal/lysosomal compartments in B-cells.

    Three dimensional structures from OCA and Proteopedia for HLA-DOB Gene

neXtProt entry for HLA-DOB Gene

Proteomics data for HLA-DOB Gene at MOPED

Post-translational modifications for HLA-DOB Gene

  • Glycosylation at Asn 45
  • Modification sites at PhosphoSitePlus

Other Protein References for HLA-DOB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HLA-DOB Gene

Domains & Families for HLA-DOB Gene

Graphical View of Domain Structure for InterPro Entry

P13765

UniProtKB/Swiss-Prot:

DOB_HUMAN :
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Belongs to the MHC class II family.
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Family:
  • Belongs to the MHC class II family.
genes like me logo Genes that share domains with HLA-DOB: view

Function for HLA-DOB Gene

Molecular function for HLA-DOB Gene

GENATLAS Biochemistry:
HLA-DO,alpha chain,expressed in B cell lysosomes,heterodimerizing with HLA-DNA to form HLA-DO,acting as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules
UniProtKB/Swiss-Prot Function:
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

Gene Ontology (GO) - Molecular Function for HLA-DOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with HLA-DOB: view
genes like me logo Genes that share phenotypes with HLA-DOB: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-DOB Gene

Localization for HLA-DOB Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-DOB Gene

Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HLA-DOB Gene COMPARTMENTS Subcellular localization image for HLA-DOB gene
Compartment Confidence
plasma membrane 3
extracellular 2
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HLA-DOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005765 lysosomal membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with HLA-DOB: view

Pathways & Interactions for HLA-DOB Gene

genes like me logo Genes that share pathways with HLA-DOB: view

Interacting Proteins for HLA-DOB Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000390020%0d%0a9606.ENSP00000229829%0d%0a9606.ENSP00000378786%0d%0a9606.ENSP00000339398%0d%0a9606.ENSP00000393566%0d%0a9606.ENSP00000364076%0d%0a
Selected Interacting proteins: ENSP00000390020 P13765-DOB_HUMAN for HLA-DOB Gene via STRING I2D

Gene Ontology (GO) - Biological Process for HLA-DOB Gene

None

No data available for SIGNOR curated interactions for HLA-DOB Gene

Drugs & Compounds for HLA-DOB Gene

No Compound Related Data Available

Transcripts for HLA-DOB Gene

Unigene Clusters for HLA-DOB Gene

Major histocompatibility complex, class II, DO beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-DOB Gene

No ASD Table

Relevant External Links for HLA-DOB Gene

GeneLoc Exon Structure for
HLA-DOB
ECgene alternative splicing isoforms for
HLA-DOB

Expression for HLA-DOB Gene

mRNA expression in normal human tissues for HLA-DOB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-DOB Gene

This gene is overexpressed in Spleen (x11.7), Whole Blood (x5.5), and Small Intestine - Terminal Ileum (x4.7).

Protein differential expression in normal tissues from HIPED for HLA-DOB Gene

This gene is overexpressed in Blymphocyte (37.3), Lymph node (14.4), and Peripheral blood mononuclear cells (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HLA-DOB Gene



SOURCE GeneReport for Unigene cluster for HLA-DOB Gene Hs.1802

genes like me logo Genes that share expression patterns with HLA-DOB: view

Protein tissue co-expression partners for HLA-DOB Gene

- Elite partner

No data available for mRNA Expression by UniProt/SwissProt for HLA-DOB Gene

Orthologs for HLA-DOB Gene

This gene was present in the common ancestor of mammals.

Orthologs for HLA-DOB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BOLA-DOB 35
  • 80.99 (n)
  • 75.19 (a)
BOLA-DOB 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DLA-DOB 35
  • 86.67 (n)
  • 84.81 (a)
DLA-DOB 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia H2-Ob 35
  • 81.11 (n)
  • 75.56 (a)
H2-Ob 16
H2-Ob 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PATR-DOB 35
  • 99.51 (n)
  • 98.9 (a)
PATR-DOB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RT1-DOb 35
  • 79.75 (n)
  • 74.81 (a)
oppossum
(Monodelphis domestica)
Mammalia HLA-DOB 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
ManyToMany
Species with no ortholog for HLA-DOB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HLA-DOB Gene

ENSEMBL:
Gene Tree for HLA-DOB (if available)
TreeFam:
Gene Tree for HLA-DOB (if available)

Paralogs for HLA-DOB Gene

genes like me logo Genes that share paralogs with HLA-DOB: view

Variants for HLA-DOB Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DOB Gene

DOB_HUMAN-P13765
The following alleles of DOB are known: DOB*01:01, DOB*01:02, DOB*01:03 and DOB*01:04. The sequence shown is that of DOB*01:01.

Sequence variations from dbSNP and Humsavar for HLA-DOB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2071554 - 32,816,899(-) GACCC(A/G)ACTGG reference, missense
rs2621330 - 32,813,747(-) GAATC(A/G)TCATC reference, missense
rs2070121 - 32,813,777(-) TCCTA(A/C/T)TTGGG reference, missense
rs11575907 - 32,814,335(-) GCCCT(A/G)TTTCT reference, missense
rs5024480 -- 32,814,251(+) AAGTG(A/C)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HLA-DOB Gene

Variant ID Type Subtype PubMed ID
nsv511120 CNV Complex 20534489
nsv510024 CNV Loss 20534489

Variation tolerance for HLA-DOB Gene

Residual Variation Intolerance Score: 62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.50; 77.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Relevant External Links for HLA-DOB Gene

Disorders for HLA-DOB Gene

Relevant External Links for HLA-DOB

Genetic Association Database (GAD)
HLA-DOB
Human Genome Epidemiology (HuGE) Navigator
HLA-DOB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HLA-DOB

No disorders were found for HLA-DOB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HLA-DOB Gene

Publications for HLA-DOB Gene

  1. The HLA-DOB gene displays limited polymorphism with only one amino acid substitution. (PMID: 12445321) Naruse T.K. … Tatsumi N. (Tissue Antigens 2002) 3 4 23 67
  2. Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation. (PMID: 15265882) Fallas J.L. … Denzin L.K. (J. Immunol. 2004) 3 23
  3. Class II transactivator is required for maximal expression of HLA-DOB in B cells. (PMID: 11823510) Nagarajan U.M. … Boss J.M. (J. Immunol. 2002) 3 23
  4. Association of polymorphisms in HLA antigen presentation-related genes with the outcomes of HCV infection. (PMID: 25874709) Huang P. … Su J. (PLoS ONE 2015) 3
  5. The activity of Nef on HIV-1 infectivity. (PMID: 24904546) Basmaciogullari S. … Pizzato M. (Front Microbiol 2014) 3

Products for HLA-DOB Gene

Sources for HLA-DOB Gene

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