HLA-DOB Gene

Aliases
for HLA-DOB gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC06M032777 GC06M032551 GC06M032827 GC06M032888 GC06M032523

Summaries
for HLA-DOB gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for HLA-DOB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000006.11  NC_018917.2  NT_007592.16  NT_113891.3  NT_167244.2  NT_167245.2  NT_167247.2  NT_167249.2  

SwitchGear Promoter luciferase reporter plasmid: HLA-DOB promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HLA-DOB

HLA-DOB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032780:  view genomic region     (about GC identifiers)

Proteins
for HLA-DOB gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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1 PDB 3D structure from and Proteopedia for HLA-DOB:

4I0P (3D)    

Explore the universe of human proteins at neXtProt for HLA-DOB: NX_P13765

Explore proteomics data for HLA-DOB at MOPED

Post-translational modifications: 

HLA-DOB Human Recombinant Protein Products:

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	OriGene Purified Protein for HLA-DOB OriGene Protein Over-expression Lysate for HLA-DOB OriGene MassSpec for HLA-DOB OriGene Custom Protein Services for HLA-DOB
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	Novus Biologicals HLA-DOB Protein Novus Biologicals HLA-DOB Lysates
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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for HLA-DOB
	Search GeneTex for Proteins for HLA-DOB
	antibodies-online proteins for HLA-DOB (3 products)
	Search antibodies-online for peptides for HLA-DOB

HLA-DOB Antibody Products:

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	Abcam antibodies for HLA-DOB
	Browse Antibodies at Cloud-Clone Corp.
	Search ThermoFisher Antibodies for HLA-DOB
	antibodies-online antibodies for HLA-DOB (22 products)

HLA-DOB Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for HLA-DOB
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HLA-DOB
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for HLA-DOB
	antibodies-online kits for HLA-DOB

Domains /
Families
for HLA-DOB gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P13765

Find genes that share domains with HLA-DOB           About GenesLikeMe

Function
for HLA-DOB gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for HLA-DOB

miRNA Products:		Block miRNA regulation of human, mouse, rat HLA-DOB using miScript Target Protectors
		5 qRT-PCR Assays for microRNAs that regulate HLA-DOB:
		hsa-miR-3154 hsa-miR-589* hsa-miR-3155 hsa-miR-3155b hsa-miR-484
		SwitchGear 3'UTR luciferase reporter plasmid: HLA-DOB 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for HLA-DOB
		Predesigned siRNA for gene silencing in human, mouse, rat HLA-DOB

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for HLA-DOB

Clone Products:		OriGene clones in human, mouse for HLA-DOB (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HLA-DOB (NM_002120)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HLA-DOB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DOB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HLA-DOB
		Browse ESI BIO Cell Lines and PureStem Progenitors for HLA-DOB

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DOB

Localization
for HLA-DOB gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
endosome	5
lysosome	5
vacuole	5
plasma membrane	3
extracellular	2
cytosol	1
mitochondrion	1
peroxisome	1

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Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

Pathways & Interactions
for HLA-DOB gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for HLA-DOB About   (see all 20)   See pathways by source

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	SuperPath	Selected contained pathways About (see all per SuperPath)
1	Allograft rejection	Allograft rejection 0.86 Intestinal immune network for IgA production 0.41 Allograft Rejection 0.86 Viral myocarditis 0.40 Type I diabetes mellitus 0.69 CTL Mediated Apoptosis 0.38 Graft-versus-host disease 0.65 THC Differentiation Pathway 0.38
2	ICos-ICosL Pathway in T-Helper Cell	ICos-ICosL Pathway in T-Helper Cell 0.66 Calcium Mediated T-Cell Apoptosis 0.31 CD28 Signaling in T-Helper Cell 0.66
3	Immune response NFAT in immune response	Immune response NFAT in immune response 0.56 Immune response T cell receptor signaling pathway 0.52 Immune response ICOS pathway in T-helper cell 0.56
4	TCR Signaling (Qiagen)	PKC-Theta Pathway 0.68 ITK and TCR Signaling 0.54 TCR Signaling 0.68
5	Immune response Antigen presentation by MHC class II	Immune response Antigen presentation by MHC class II 0.52 Immune response IL-22 signaling pathway 0.36 G-protein signaling N-RAS regulation pathway 0.52

Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HLA-DOB

	THC Differentiation Pathway
	Calcium Mediated T-Cell Apoptosis
	IL-4 Pathway
	ICos-ICosL Pathway in T-Helper Cell
	CDC42 Pathway

Selected GeneGo (Thomson Reuters) Pathways for HLA-DOB

	Immune response Antigen presentation by MHC class II
	Immune response ICOS pathway in T-helper cell
	Immune response T cell receptor signaling pathway
	Immune response IL-22 signaling pathway
	G-protein signaling N-RAS regulation pathway

1 BioSystems Pathway for HLA-DOB

Allograft Rejection

1 Reactome Pathway for HLA-DOB

MHC class II antigen presentation

Selected Kegg Pathways  (Kegg details for HLA-DOB)

	Phagosome
	Cell adhesion molecules (CAMs)
	Antigen processing and presentation
	Intestinal immune network for IgA production
	Type I diabetes mellitus

Gene Ontology (GO): 4 biological process terms:    About this table

Drugs & Compounds
for HLA-DOB gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for HLA-DOB gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for HLA-DOB gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HLA-DOB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AGGTCAATGT

About this image

Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
Muscle Progenitor Cells Mandibular Arch Muscles
Adipose (Muscoskeletal System)
Body Subcutaneous White Adipose
Blood (Hematopoietic System)
Mature B-Cells Peripheral Blood

Primer Products:		OriGene qPCR primer pairs and template standards for HLA-DOB OriGene qSTAR qPCR primer pairs in human, mouse for HLA-DOB
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HLA-DOB
		QuantiTect SYBR Green Assays in human, mouse, rat HLA-DOB
		QuantiFast Probe-based Assays in human, mouse, rat HLA-DOB

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DOB

Orthologs
for HLA-DOB gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for HLA-DOB gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for HLA-DOB gene

HLA-DRB5²  HLA-DQA1²  HLA-DPA1²  HLA-DQB1²  HLA-DRA²  HLA-DRB1²  HLA-DMA²  HLA-DQB2²  

HLA-DOA²  ENSG00000248993²  HLA-DMB²  HLA-DQA2²  HLA-DPB1²  

Selected SIMAP similar genes for HLA-DOB using alignment to 6 protein entries:     DOB_HUMAN (see all proteins) (see all similar genes):

HLA DRB4    HLA-DQB1I    HLA-DRB4*0102    HLA-DQB1*06new1    MHC class II HLA-DRB1 Exon-2    HLA-DQB1*03

HLA-DQB1/DRB1    HLA-DR4/Dw13    HLA-DRB13    HLA-DRB4    DQB1.SLE    DQB1

HLQ-DQB1    HLA-DQB1*06x    HLA-DR-beta 1    DQB1-02    DRB1*0405V3    HLA-DR beta

Find genes that share paralogs with HLA-DOB           About GenesLikeMe

Genomic Variants
for HLA-DOB gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HLA-DOB (see all 203)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1864944031,2		--	32780085(+)	CACCAC/TGTATA	1	--	ds5001		0	--	--	--	--
rs1917982521,2		--	32780089(+)	ACGTAC/TAGATT	1	--	ds5001		0	--	--	--	--
rs587205411,2	C	--	32780117(+)	ACCAG-/AGTCTGA	1	--	ds5001		0	--	--	--	--
rs92768071,2	C,F	--	32780156(+)	TTTGCG/AGGAGG	1	--	ds5001		7		WA NA CSA EA	366
rs28571131,2	C,F,A,H	--	32780201(-)	gctgcA/Gtacac	1	--	ds5001		9		WA NA CSA EA	372
rs1404270831,2		--	32780223(+)	AGAGTA/GTGGGA	1	--	ds5001		0	--	--	--	--
rs340227941,2	C	--	32780281(+)	GGGGG-/AAAAAA	1	--	ds5001		0	--	--	--	--
rs28571121,2	C,H	--	32780294(-)	CCCCCA/TTCAGC	1	--	ds5001		3		NA WA	240
rs26213321,2	C,F,A,H	--	32780317(-)	TCTCTT/CATACT	1	--	ds5001		23		NS EA WA NA CSA	2782
rs1496652591,2	C	--	32780346(+)	TGTGGA/CGTCCA	1	--	ds5001		0	--	--	--	--

HapMap Linkage Disequilibrium report for HLA-DOB (32780540 - 32784825 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for HLA-DOB:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv510024	CNV	Loss	20534489
nsv511120	CNV	Complex	20534489

Locus Specific Mutation Databases (LSDB): HLA-DOB

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing HLA-DOB

DNA2.0 Custom Variant and Variant Library Synthesis for HLA-DOB

Disorders / Diseases
for HLA-DOB gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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1 disease for HLA-DOB

1 Novoseek inferred disease relationship for HLA-DOB gene    About this table

Publications
for HLA-DOB gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. The HLA-DOB gene displays limited polymorphism with only one amino acid substitution. (PubMed id 12445321)^{1, 2, 9} Naruse T.K....Tatsumi N. (Tissue Antigens 2002)
2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)^{1, 4} Barcellos L.F....Criswell L.A. (PLoS Genet. 2009)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
5. Evolutionary dynamics of non-coding sequences within the class II region of the human MHC. (PubMed id 8568858)^{1, 2} Beck S.... Trowsdale J. (J. Mol. Biol. 1996)
6. DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing. (PubMed id 1453454)^{1, 2} Beck S....Trowsdale J. (J. Mol. Biol. 1992)
7. Human class II DNA and DOB genes display low sequence variability. (PubMed id 2499532)^{1, 2} Jonsson A.-K. and Rask L. (Immunogenetics 1989)
8. Class II genes of the human major histocompatibility complex. The DO beta gene is a divergent member of the class II beta gene family. (PubMed id 3036827)^{1, 2} Servenius B.... Peterson P.A. (J. Biol. Chem. 1987)
9. DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression. (PubMed id 2998758)^{1, 2} Tonnelle C.... Long E.O. (EMBO J. 1985)
10. Class II transactivator is required for maximal expression of HLA-DOB in B cells. (PubMed id 11823510)^{1, 9} Nagarajan U.M....Boss J.M. (J. Immunol. 2002)

External Searches for HLA-DOB gene

Genome Databases showing HLA-DOB gene

Other Databases showing HLA-DOB gene

Specialized Databases showing HLA-DOB gene

Products
for HLA-DOB gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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