Aliases for HLA-DOB Gene
Aliases for HLA-DOB Gene
External Ids for HLA-DOB Gene
- HGNC: 4937
- Entrez Gene: 3112
- Ensembl: ENSG00000241106
- OMIM: 600629
- UniProtKB: P13765
Previous GeneCards Identifiers for HLA-DOB Gene
- GC06M032777
- GC06M032551
- GC06M032827
- GC06M032888
- GC06M032523
Summaries for HLA-DOB Gene
-
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
GeneCards Summary for HLA-DOB Gene
HLA-DOB (Major Histocompatibility Complex, Class II, DO Beta) is a Protein Coding gene. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding and MHC class II receptor activity. An important paralog of this gene is HLA-DRB1.
UniProtKB/Swiss-Prot for HLA-DOB Gene
-
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-DOB Gene
Genomics for HLA-DOB Gene
Regulatory Elements for HLA-DOB Gene
Enhancers for HLA-DOB Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HLA-DOB on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HLA-DOB gene promoter:
Regulatory Element Products
Genomic Location for HLA-DOB Gene
- Chromosome:
- 6
- Start:
- 32,812,763 bp from pter
- End:
- 32,817,048 bp from pter
- Size:
- 4,286 bases
- Orientation:
- Minus strand
Genomic View for HLA-DOB Gene
Genes around HLA-DOB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.32 by Ensembl
- 6p21.32 by Entrez Gene
- 6p21.32 by HGNC
HLA-DOB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HLA-DOB Gene
Proteins for HLA-DOB Gene
-
Protein details for HLA-DOB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P13765-DOB_HUMAN
- Recommended name:
- HLA class II histocompatibility antigen, DO beta chain
- Protein Accession:
- P13765
- B0V0Y0
- Q29746
- Q29825
- Q6FHC2
Protein attributes for HLA-DOB Gene
- Size:
- 273 amino acids
- Molecular mass:
- 30822 Da
- Quaternary structure:
-
- Heterodimer of an alpha chain (DOA) and a beta chain (DOB). Forms a heterotetrameric complex with an HLA-DM molecule during intracellular transport in endosomal/lysosomal compartments in B-cells.
Protein Expression for HLA-DOB Gene
Post-translational modifications for HLA-DOB Gene
Other Protein References for HLA-DOB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HLA-DOB
-
Abcam antibodies for HLA-DOB
- Invitrogen Antibodies for HLA-DOB
- antibodies-online Antibodies for HLA-DOB: See all 34
- Search GeneTex for Antibodies for HLA-DOB
-
Santa Cruz Biotechnology (SCBT) Antibodies for HLA-DOB
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HLA-DOB
- Origene Custom Protein Services for HLA-DOB
- ProSpec Recombinant Proteins for HLA-DOB
- antibodies-online Proteins for HLA-DOB: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HLA-DOB
-
Abcam proteins for HLA-DOB
No data available for DME Specific Peptides for HLA-DOB Gene
Domains & Families for HLA-DOB Gene
Gene Families for HLA-DOB Gene
Protein Domains for HLA-DOB Gene
Suggested Antigen Peptide Sequences for HLA-DOB Gene
- GenScript: Design optimal peptide antigens:
-
- Major histocompatibility complex, class II, DO beta (A2ACQ8_HUMAN)
- Major histocompatibility complex, class II, DO beta (A2ADX4_HUMAN)
- Major histocompatibility complex, class II, DO beta (B0V0S3_HUMAN)
- Major histocompatibility complex, class II, DO beta (B0V0Y1_HUMAN)
- Major histocompatibility complex, class II, DO beta (B0V2J6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P13765- Family:
-
- Belongs to the MHC class II family.
Function for HLA-DOB Gene
Molecular function for HLA-DOB Gene
- GENATLAS Biochemistry:
- HLA-DO,alpha chain,expressed in B cell lysosomes,heterodimerizing with HLA-DNA to form HLA-DO,acting as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules
- UniProtKB/Swiss-Prot Function:
- Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0023026 | MHC class II protein complex binding | IDA | 22733780 |
| GO:0032395 | MHC class II receptor activity | TAS | 2998758 |
Phenotypes for HLA-DOB Gene
- GenomeRNAi human phenotypes for HLA-DOB:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HLA-DOB
-
-
ViGene Biosciences ready-to-package AAV shRNAs for HLA-DOB gene
- Search ViGene Biosciences for HLA-DOB
CRISPR Products
- Browse CRISPR knockouts for HLA-DOB
-
Santa Cruz Biotechnology (SCBT) CRISPR for HLA-DOB
- GenScript: Design CRISPR guide RNA sequences for HLA-DOB
miRNA for HLA-DOB Gene
- miRTarBase miRNAs that target HLA-DOB
miRNA Products
- Search ViGene Biosciences for HLA-DOB
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for HLA-DOB gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HLA-DOB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HLA-DOB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for HLA-DOB
-
ViGene Biosciences adenoviral particle packaged cDNA for HLA-DOB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HLA-DOB gene
- Search ViGene Biosciences for HLA-DOB
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-DOB Gene
Localization for HLA-DOB Gene
Subcellular locations from UniProtKB/Swiss-Prot for HLA-DOB Gene
- Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| lysosome | 5 |
| endosome | 5 |
| extracellular | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005764 | lysosome | IDA | 8890155 |
| GO:0005765 | lysosomal membrane | TAS | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0010008 | endosome membrane | IEA | -- |
Pathways & Interactions for HLA-DOB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Allograft rejection |
.44
|
|
| 2 | Th17 cell differentiation | ||
| 3 | ICos-ICosL Pathway in T-Helper Cell | ||
| 4 | TCR Signaling (Qiagen) |
.68
|
|
| 5 | Immune response NFAT in immune response | ||
Pathways by source for HLA-DOB Gene
1 BioSystems pathway for HLA-DOB Gene
3 Reactome pathways for HLA-DOB Gene
23 KEGG pathways for HLA-DOB Gene
6 GeneGo (Thomson Reuters) pathways for HLA-DOB Gene
12 Qiagen pathways for HLA-DOB Gene
Interacting Proteins for HLA-DOB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | IEA | -- |
| GO:0002587 | negative regulation of antigen processing and presentation of peptide antigen via MHC class II | IDA | 22733780 |
| GO:0006955 | immune response | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0019882 | antigen processing and presentation | IEA | -- |
No data available for SIGNOR curated interactions for HLA-DOB Gene
Transcripts for HLA-DOB Gene
mRNA/cDNA for HLA-DOB Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (65) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HLA-DOB Gene
CRISPR Products
- Browse CRISPR knockouts for HLA-DOB
-
Santa Cruz Biotechnology (SCBT) CRISPR for HLA-DOB
- GenScript: Design CRISPR guide RNA sequences for HLA-DOB
miRNA Products
- Search ViGene Biosciences for HLA-DOB
Inhibitory RNA Products
-
ViGene Biosciences ready-to-package AAV shRNAs for HLA-DOB gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HLA-DOB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HLA-DOB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for HLA-DOB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Muscle Progenitor Cells Mandibular Arch Muscles
- Muscle Progenitor Cells Hyoid Arch Muscles
-
Blood (Hematopoietic System)
- Mature B-Cells Peripheral Blood
- Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for HLA-DOB Gene
This gene is overexpressed in Spleen (x11.7), Whole Blood (x5.5), and Small Intestine - Terminal Ileum (x4.7).
This gene is overexpressed in Blymphocyte (37.3), Lymph node (14.4), and Peripheral blood mononuclear cells (11.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HLA-DOB Gene
- Elite partner
SOURCE GeneReport for Unigene cluster for HLA-DOB Gene:
Hs.1802Evidence on tissue expression from TISSUES for HLA-DOB Gene
- Blood(2.3)
- Heart(2.1)
Primer Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HLA-DOB Gene
Orthologs for HLA-DOB Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PATR-DOB 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | DLA-DOB 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | H2-Ob 34 16 35 |
|
||
| cow (Bos Taurus) |
Mammalia | BOLA-DOB 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | RT1-DOb 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HLA-DOB 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany |
- Species where no ortholog for HLA-DOB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HLA-DOB Gene
Paralogs for HLA-DOB Gene
(106) SIMAP similar genes for HLA-DOB Gene using alignment to 6 proteins:
- HLA DRB4
- HLA-DQB1I
- HLA-DRB4*0102
- HLA-DQB1*06new1
- MHC class II HLA-DRB1 Exon-2
- HLA-DQB1*03
- HLA-DQB1/DRB1
- HLA-DRB13
- HLA-DR4/Dw13
- HLA-DQB1*05
- HLA-DRB4
- DQB1.SLE
- HLQ-DQB1
- DQB1
- HLA-DR-beta 1
- HLA-DQB1*06x
- MHC-DPB1*6001
- HLADRB1
- HLA-DRBI*1303
- HLA-DRB3*01
- HLA-DRB14
- HLA-DR beta
- DRB1*0405V3
- DQB1-02
- HLA-DQ
- HLA-DR4
- HLA DQB1
- HLA-DRB1*1605
- HLA-DRB3
- HLA-DQB3
- HLA-DB1
- HLA-DQB
- HLA-DQB1
- HLA-DRB2
- HLA-DR4I
- MHC Class II HLA DRB1
- HLA-DRB1*1327
- HLA DRB1 gene
- DRB1 HAG
- HLA-Dw12
- HLA-DQ-beta
- HLA-DQ3
- HLA-DQB2
- HLA-DRB1*
- HLA-DBR1
- MHC class II HLA DRB1
- HLA-DRB1*0801
- HLA-DRB1*04
- HLA-DR3
- DRB52
- HLA-DQB1*05
- HLA-DRB
- HLA-DRB5
- HLA-DRB1*11
- HLA-D8.2V
- DRB1*08
- DQB1*0603
- DPB1
- HLA-DPB1
- HLA-DR
- DRB1*1303
- DRB1*11
- HLA DRB1
- DRB1
- HLA-DR15
- HLA-DRB1
- HLA-D
- MHC class II HLA DRB1-0305
- HLA-DRBI
- DRB1*13PL
- HLA-DR-beta1
- HLA-DRB1*1324
- HLA-DRw12
- HLA-DPB
- HLA-DRB7
- HLA-DRB4* variant allele
- HLA-DRB11
- HLA-DRB1*1125
- HLA-DRB1*0818
- DRB4
- HLA-DP
- HLA DRB1*1202
- HLA-DR08
- HLA-DRB1-0811
- HLA-DRB1*1302Var
- HLA
- DRB1*LY10
- MHC class II HLA-DRB1*1315
- MHC DPB1
- HLA-DRB1-11
- HLA-DRB1*08
- HLA-DR-beta
- HLA-DRB52
- DRB1*1116
- HLA-DRB1-1113
- HLA-C
- HLA-A
- IGLC1
- HLA-DRB9
- C1 segment
- HLA-DMB
- HLA-A*0201V3
- B2M
- IGLC7
- IGLC6
- DKFZp667J0810
Variants for HLA-DOB Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DOB Gene
- DOB_HUMAN-P13765
- The following alleles of DOB are known: DOB*01:01, DOB*01:02, DOB*01:03 and DOB*01:04. The sequence shown is that of DOB*01:01.
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000128687 | -- | 32,813,181(+) | ACTAC(A/T)TCAGG | utr-variant-3-prime | |
| rs1000928748 | -- | 32,817,209(+) | TTTAG(A/G)TATAC | upstream-variant-2KB | |
| rs1001263464 | -- | 32,813,110(+) | GAAGA(A/G)AGTTA | utr-variant-3-prime | |
| rs1001337250 | -- | 32,813,385(+) | TCTGG(C/T)CAAAG | intron-variant | |
| rs1001411351 | -- | 32,812,377(+) | AATTT(A/G)CGGGA | downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1759e212 | CNV | loss | 25503493 |
| nsv1073969 | CNV | deletion | 25765185 |
| nsv1112900 | CNV | deletion | 24896259 |
| nsv1119076 | CNV | deletion | 24896259 |
| nsv510024 | OTHER | sequence alteration | 20534489 |
| nsv511120 | OTHER | complex | 20534489 |
Residual Variation Intolerance Score:
62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.50;
77.59% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HLA-DOB Gene
Disorders for HLA-DOB Gene
Relevant External Links for HLA-DOB
No disorders were found for HLA-DOB Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HLA-DOB Gene
Publications for HLA-DOB Gene
- The HLA-DOB gene displays limited polymorphism with only one amino acid substitution. (PMID: 12445321) Naruse T.K. … Tatsumi N. (Tissue Antigens 2002) 3 4 22 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
- Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation. (PMID: 15265882) Fallas J.L. … Denzin L.K. (J. Immunol. 2004) 3 22 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for HLA-DOB Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Custom Antibody Services
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- Origene Custom Protein Services for HLA-DOB
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- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for HLA-DOB
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HLA-DOB
- GenScript: Next-day shipping cDNA ORF clone for HLA-DOB in any vector
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- GenScript Custom Assay Services for HLA-DOB
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- GenScript: Design CRISPR guide RNA sequences for HLA-DOB
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
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- Novus Biologicals Antibodies for HLA-DOB
- Novus Biologicals proteins and lysates for HLA-DOB
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for HLA-DOB
- Abcam proteins for HLA-DOB
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- ProSpec Recombinant Proteins for HLA-DOB
- Invitrogen Antibodies for HLA-DOB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for HLA-DOB: See all 34
- Search antibodies-online for kits
- antibodies-online Proteins for HLA-DOB: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for HLA-DOB
- Search GeneTex for Proteins for HLA-DOB
- ViGene Biosciences adenoviral particle packaged cDNA for HLA-DOB gene
- ViGene Biosciences ready-to-package AAV shRNAs for HLA-DOB gene
- Search ViGene Biosciences for HLA-DOB
- Santa Cruz Biotechnology (SCBT) Antibodies for HLA-DOB
- Search Santa Cruz Biotechnology (SCBT) for HLA-DOB siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HLA-DOB
- Horizon Cell Lines for HLA-DOB
- Cyagen custom Knockout/knockin (KOKI) mouse models for HLA-DOB
- VectorBuilder custom plasmid, inducible vectors for HLA-DOB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HLA-DOB
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HLA-DOB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
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