Aliases for HLA-DOA Gene
External Ids for HLA-DOA Gene
Previous HGNC Symbols for HLA-DOA Gene
Previous GeneCards Identifiers for HLA-DOA Gene
HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]
GeneCards Summary for HLA-DOA Gene
HLA-DOA (Major Histocompatibility Complex, Class II, DO Alpha) is a Protein Coding gene. Diseases associated with HLA-DOA include Keshan Disease. Among its related pathways are HTLV-I infection and G-protein signaling N-RAS regulation pathway. GO annotations related to this gene include MHC class II protein complex binding and MHC class II receptor activity. An important paralog of this gene is HLA-DQA1.
UniProtKB/Swiss-Prot for HLA-DOA Gene
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.