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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HLA-DOA Gene

protein-coding   GIFtS: 57
GCID: GC06M032971

major histocompatibility complex, class II, DO alpha


(Previous symbols: HLA-DZA, HLA-DNA)
 Explore 19 diseases affiliated with
HLA-DOA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HLA-DOA    

Aliases
for HLA-DOA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Major Histocompatibility Complex, Class II, DO Alpha1 2     MHC DZ Alpha2 3
HLA-DNA1 2 3 5     HLADZ2
HLA-DZA1 2 3     HLA Class II Histocompatibility Antigen, DO Alpha Chain2
HLA-D0-Alpha1     Lymphocyte Antigen2
MHC Class II Antigen DOA2 3     Major Histocompatibility Complex, Class II, DN Alpha2
MHC DN-Alpha2 3     

External Ids:    HGNC: 49361   Entrez Gene: 31112   Ensembl: ENSG000002042527   OMIM: 1429305   UniProtKB: P063403   

Export aliases for HLA-DOA gene to outside databases

Previous GC identifers: GC06M032976 GC06M033020 GC06M033081 GC06M032714


Summaries
for HLA-DOA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HLA-DOA:
HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer,
HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In
comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the
protein level. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DOA_HUMAN, P06340
Function: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the
HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM

Gene Wiki entry for HLA-DOA


Genomic Views
for HLA-DOA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HLA-DOA gene promoter:
         USF1   AML1a   SREBP-1c   HNF-4alpha1   Roaz   SREBP-1b   PPAR-gamma1   SREBP-1a   USF-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HLA-DOA promoter sequence
   Search SABiosciences Chromatin IP Primers for HLA-DOA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HLA-DOA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

HLA-DOA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HLA-DOA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032971:  view genomic region     (about GC identifiers)

Start:
 32,971,955 bp from pter      End:
 32,977,389 bp from pter
Size:
 5,435 bases      Orientation:
 minus strand

6 alternative locations:
Chr6-,ALT_REF_LOCI_3 32,949,907-32,966,378      Chr6-,ALT_REF_LOCI_6 32,900,651-32,941,666      Chr6-,ALT_REF_LOCI_2 32,894,248-32,938,870     
Chr6-,ALT_REF_LOCI_4 33,048,810-33,054,239      Chr6-,ALT_REF_LOCI_5 32,920,245-32,925,675      Chr6-,ALT_REF_LOCI_7 33,042,140-33,047,569     

Proteins
for HLA-DOA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DOA_HUMAN, P06340 (See protein sequence)
Recommended Name: HLA class II histocompatibility antigen, DO alpha chain precursor  
Size: 250 amino acids; 27599 Da
Subunit: Heterodimer of an alpha chain (DOA) and a beta chain (DOB). Forms a heterotetrameric complex with an HLA-DM
molecule during intracellular transport in endosomal/lysosomal compartments in B-cells
Subcellular location: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I
membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal
compartments. Heterotetramerization is necessary to exit the ER
1 PDB 3D structure from and Proteopedia for HLA-DOA:
4I0P (3D)    
Secondary accessions: Q58HU0 Q58HU1 Q5STC7 Q9TQC6 Q9TQC7 Q9TQC8 Q9TQC9 Q9TQD0 Q9TQD1 Q9TQD2 Q9TQD3

Explore the universe of human proteins at neXtProt for HLA-DOA: NX_P06340

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P06340

    • HLA-DOA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002110.1  
    ENSEMBL proteins: 
     ENSP00000229829   ENSP00000363946   ENSP00000403896  
    Reactome Protein details: P06340
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HLA-DOA
    OriGene Custom Protein Services for HLA-DOA 
    GenScript Custom Purified and Recombinant Proteins Services for HLA-DOA
    Novus Biologicals HLA-DOA Protein
    Novus Biologicals HLA-DOA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane TAS--
    GO:0005886plasma membrane TAS3000765
    GO:0010008endosome membrane IEA--
    GO:0016021integral to membrane IEA--
    GO:0042613MHC class II protein complex IEA--


    HLA-DOA for ontologies           About GeneDecksing



    HLA-DOA Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals HLA-DOA Antibodies
    Search for Antibodies for HLA-DOA at Abcam  
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for HLA-DOA

    Assay Products for HLA-DOA: 
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for HLA-DOA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HLA-DOA for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR001003 MHC_II_a_N
     IPR011162 MHC_I/II-like_Ag-recog
     IPR013783 Ig-like_fold
     IPR014745 MHC_II_a/b_N
     IPR003597 Ig_C1-set

    Graphical View of Domain Structure for InterPro Entry P06340

    ProtoNet protein and cluster: P06340

    2 Blocks protein families:
    IPB001003 MHC Class II alpha chain
    IPB003597 Immunoglobulin C-type


    UniProtKB/Swiss-Prot: DOA_HUMAN, P06340
    Similarity: Belongs to the MHC class II family
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain


    Function
    for HLA-DOA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DOA_HUMAN, P06340
    Function: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the
    HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM

    miRNA
    Products:            		 OriGene 3'-UTR Clone: HLA-DOA
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-DOA
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate HLA-DOA:
    hsa-miR-203 hsa-miR-3132 hsa-miR-922 hsa-miR-4251 hsa-miR-532-3p hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmid: HLA-DOA 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLA-DOA
    OriGene shRNA RFP: HLA-DOA
    OriGene siRNA: HLA-DOA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-DOA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HLA-DOA

    Clone
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    GenScript: all cDNA clones in your preferred vector: HLA-DOA (NM_002119)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HLA-DOA 

    Cell Line
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    Search LifeMap BioReagents cell lines for HLA-DOA

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DOA

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032395MHC class II receptor activity TAS3000765


    HLA-DOA for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out H2-OaH2-tm1Lkar for HLA-DOA
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for H2-Oa):
     hematopoietic system  immune system 

    HLA-DOA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HLA-DOA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Allograft rejection
    8/10 pathways (see all 10)
    		Allograft rejection1.00
    		THC Differentiation Pathway0.39
    		Type I diabetes mellitus0.67
    		CTL Mediated Apoptosis0.38
    		Graft-versus-host disease0.63
    		Intestinal immune network for IgA production0.38
    		Autoimmune thyroid disease0.60
    		Viral myocarditis0.33
    2ICos-ICosL Pathway in T-Helper Cell
    		ICos-ICosL Pathway in T-Helper Cell1.00
    		Calcium Mediated T-Cell Apoptosis0.31
    		CD28 Signaling in T-Helper Cell0.66
    3PKC-Theta Pathway
    		PKC-Theta Pathway1.00
    		ITK and TCR Signaling0.54
    		TCR Signaling0.68
    4Immune response_NFAT in immune response
    		Immune response_NFAT in immune response1.00
    		Immune response NFAT in immune response0.91
    5Immune response_ICOS pathway in T-helper cell
    		Immune response_ICOS pathway in T-helper cell1.00
    		Immune response ICOS pathway in T-helper cell0.91

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/6 EMD Millipore Pathways for HLA-DOA (see all 6)
        Immune response Antigen presentation by MHC class II
    G-protein signaling N-RAS regulation pathway
    Immune response IL-22 signaling pathway
    Immune response NFAT in immune response
    Immune response ICOS pathway in T-helper cell

    5/12 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HLA-DOA (see all 12)
        THC Differentiation Pathway
    Calcium Mediated T-Cell Apoptosis
    IL-4 Pathway
    ICos-ICosL Pathway in T-Helper Cell
    CDC42 Pathway

    5/6 GeneGo (Thomson Reuters) Pathways for HLA-DOA (see all 6)
        Immune response Antigen presentation by MHC class II
    Immune response ICOS pathway in T-helper cell
    Immune response T cell receptor signaling pathway
    Immune response IL-22 signaling pathway
    G-protein signaling N-RAS regulation pathway

    3        Reactome Pathways for HLA-DOA
        Adaptive Immune System
    Immune System
    MHC class II antigen presentation


    5/17         Kegg Pathways  (Kegg details for HLA-DOA) (see all 17):
        Phagosome
    Cell adhesion molecules (CAMs)
    Antigen processing and presentation
    Intestinal immune network for IgA production
    Type I diabetes mellitus


    HLA-DOA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HLA-DOA

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for HLA-DOA (P063403 ENSP000002298294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-DMAENSP000003639764STRING: ENSP00000363976
    --Q6ICR93I2D: score=2 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002504antigen processing and presentation of peptide or polysaccharide antigen via MHC class II ----
    GO:0006955immune response IEA--
    GO:0019221cytokine-mediated signaling pathway ----
    GO:0019882antigen processing and presentation ----
    GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II TAS--


    HLA-DOA for ontologies           About GeneDecksing



    Drugs & Compounds
    for HLA-DOA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HLA-DOA
    Search CenterWatch for drugs/clinical trials and news about HLA-DOA / DOA 

    Transcripts
    for HLA-DOA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HLA-DOA gene: 
    NM_002119.3  

    Unigene Cluster for HLA-DOA:

    Major histocompatibility complex, class II, DO alpha
    Hs.631991  [show with all ESTs]
    Unigene Representative Sequence: NM_002119
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000229829(uc003ocr.3 uc010juj.3 uc010jui.3) ENST00000490305
    ENST00000485901 ENST00000495532 ENST00000374813 ENST00000467465 ENST00000450833


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HLA-DOA
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate HLA-DOA:
    hsa-miR-203 hsa-miR-3132 hsa-miR-922 hsa-miR-4251 hsa-miR-532-3p hsa-miR-3921
    SwitchGear 3'UTR luciferase reporter plasmid: HLA-DOA 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HLA-DOA
    OriGene shRNA RFP: HLA-DOA
    OriGene siRNA: HLA-DOA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HLA-DOA
    Clone
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    GenScript: all cDNA clones in your preferred vector: HLA-DOA (NM_002119)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DOA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DOA

    Additional cDNA sequence: 

    AJ420585.1 AK290714.1 AK301404.1 AK310153.1 AK313551.1 BC013183.1 M26039.1 M29335.1 
    M31525.1 M38054.1 M38056.1 

    6 DOTS entries:

    DT.409221  DT.40115327  DT.86847068  DT.92422220  DT.86847067  DT.95201674 

    24/121 AceView cDNA sequences (see all 121):

    BX108461 AI866383 BG758063 AA935283 AI357064 BQ182553 AI627561 AI372080 
    BQ016622 AA721167 M31525 AI701344 AI287916 AI435220 M38056 AA663927 
    AI886812 AA827172 AI474796 AI719842 AA485172 M38054 CA437002 AI096854 

    GeneLoc Exon Structure


    Expression
    for HLA-DOA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HLA-DOA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGGCTCGCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HLA-DOA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Umbilical CordUmbilical VeinsUmbilical Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See HLA-DOA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HLA-DOA

    SOURCE GeneReport for Unigene cluster: Hs.631991
        SABiosciences Custom PCR Arrays for HLA-DOA
    Primer
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    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HLA-DOA
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HLA-DOA
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HLA-DOA

    Orthologs
    for HLA-DOA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HLA-DOA gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 47(a)
    45(a)
    		 many ↔ many
    many ↔ many
    		 GL343775.1(36865-38243)
    GL343809.1(2435-3996)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:ch73-211l2.36
    si:busm1-160c18.16
    (see all 10)    		 si:busm1-160c18.1
    (see all 10)    		 28(a)
    27(a)
    (see all 10)    		 many ↔ many
    many ↔ many
    (see all 10)    		 8(47078720-47080882)
    8(36131728-36140054)


    ENSEMBL Gene Tree for HLA-DOA (if available)
    TreeFam Gene Tree for HLA-DOA (if available) 

    Paralogs
    for HLA-DOA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HLA-DOA gene
    HLA-DRB52  HLA-DQA12  HLA-DPA12  HLA-DQB12  HLA-DRA2  HLA-DOB2  HLA-DRB12  HLA-DMA2  
    HLA-DQB22  ENSG000002489932  HLA-DMB2  HLA-DQA22  HLA-DPB12  
    18/27 SIMAP similar genes for HLA-DOA using alignment to 10 protein entries:     DOA_HUMAN (see all proteins) (see all similar genes):
    DQ-A1    HLA-DQA1/DRA    HLA-DQA2    HLA-DQA1    HLA-DRA1    HLA-DPA1
    DQA1-0103    HLA    HLA-DRA    HLA DRB4    HLA-DRB4*0102    HLA-DRB4
    HLA-DRB5    HLA-DRB1    HLA-DQB1    IGLC6    HLA-DMA    DMA

    HLA-DOA for paralogs           About GeneDecksing



    Genomic Variants
    for HLA-DOA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: DOA_HUMAN, P06340
    Polymorphism: The following alleles of DOA are known: DOA*01:01, DOA*01:02 and DOA*01:03. The sequence shown is that of
    DOA*01:01


    10/236 NCBI SNPs in HLA-DOA are shown (see all 236)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs172205351,2
    		F--32714116(+) AGAGCG/ATGACC 1 -- ds50011Minor allele frequency- A:0.04MN 56
    rs172141341,2
    		C,F,H,--32714190(+) TAGGAG/AAGATG 1 -- ds50014Minor allele frequency- A:0.02MN NS NA 460
    rs69225121,2
    		C,F,A,H,--32714263(+) GACTAC/TTGGAT 1 -- ds50018Minor allele frequency- T:0.01NS EA NA WA 996
    rs172141481,2
    		C,F,--32714670(+) CGCCCC/TGGGGC 1 -- ut31 ese32Minor allele frequency- T:0.05MN WA 174
    rs31289331,2
    		C,F,A,H,--32714671(+) GCCCCG/AGGGCT 1 -- ut31 ese314Minor allele frequency- A:0.05NS EA MN WA NA 2082
    rs31306021,2
    		C,F,O,H,--32714715(+) TGATTC/TCTGCT 1 -- ut3123Minor allele frequency- T:0.04NS EA NA MN WA 2762
    rs1116647811,2
    		C,--32714923(+) GCAGGC/GGGGTC 1 -- ut310--------
    rs30976471,2
    		C,--32715768(+) gagacC/Tccatc 1 -- ut310--------
    rs715653601,2
    		C,--32715811(+) TGCACT/CCCCGA 1 -- ut313Minor allele frequency- C:0.11NA WA 240
    rs665914261,2
    		C,F--32715982(+) AGCCTC/-CCCCC 1 -- ut312Minor allele frequency- -:0.50NA 4

    HapMap Linkage Disequilibrium report for HLA-DOA (32971955 - 32977389 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HLA-DOA
         1 CNV: 0076
    Human Gene Mutation Database (HGMD): HLA-DOA

    Locus Specific Mutation Databases (LSDB): HLA-DOA

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HLA-DOA
    DNA2.0 Custom Variant and Variant Library Synthesis for HLA-DOA

    Disorders / Diseases
    for HLA-DOA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HLA-DOA for disorders           About GeneDecksing

    OMIM gene information: 142930    OMIM disorders: --

    19 diseases for HLA-DOA:    About MalaCards
    vogt-koyanagi-harada disease    graft versus host disease    alopecia universalis    systemic lupus erythematosus
    lupus erythematosus    alopecia    autoimmune thyroiditis    diabetes mellitus
    rheumatoid arthritis    toxoplasmosis    leishmaniasis    hepatitis b
    arthritis    influenza    thyroiditis    asthma
    hepatitis    tuberculosis    immunodeficiency

    1 Novoseek disease relationship for HLA-DOA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hla-do 97.7 1 11823510 (1)

    Human Genome Epidemiology (HuGE) Navigator: HLA-DOA (12 documents)

    Export disorders for HLA-DOA gene to outside databases

    Publications
    for HLA-DOA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HLA-DOA gene, integrated from 9 sources (see all 76):
    (articles sorted by number of sources associating them with HLA-DOA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript. (PubMed id 2370084)1, 2, 3 Young J.A. and Trowsdale J. (1990)
    2. Limited polymorphism in the HLA-DOA gene. (PubMed id 10323340)1, 2, 9 Naruse T.K.... Inoko H. (1999)
    3. Identification of four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, by sequence-based typing*. (PubMed id 16101837)1, 2 Moon S.M.... Oh B. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. Human class II DNA and DOB genes display low sequence variability. (PubMed id 2499532)1, 2 Jonsson A.-K. and Rask L. (1989)
    7. The human HLA class II alpha chain gene DZ alpha is distinct from genes in the DP, DQ and DR subregions. (PubMed id 3000765)1, 2 Trowsdale J. and Kelly A. (1985)
    8. Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation. (PubMed id 15265882)1, 9 Fallas J.L....Denzin L.K. (2004)
    9. HIV-1 Gag-virus-like particles induce natural killer c ell immune responses via activation and maturation of dendritic cells. (PubMed id 21778700)1 Chang M.O....Takaku H. (2012)
    10. Mapping the HLA-DO/HLA-DM complex by FRET and mutagene sis. (PubMed id 22733780)1 Yoon T....Mellins E.D. (2012)

    External Searches for HLA-DOA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HLA-DOA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3111 HGNC: 4936 AceView: HLA-DOA Ensembl:ENSG00000204252 euGenes: HUgn3111
    ECgene: HLA-DOA Kegg: 3111 H-InvDB: HLA-DOA

    Other Databases showing HLA-DOA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HLA-DOA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HLA-DOA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HLA-DOA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HLA-DOA gene:
    Search GeneIP for patents involving HLA-DOA

    GeneCards and IP:
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