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Aliases for HLA-DOA Gene

Aliases for HLA-DOA Gene

  • Major Histocompatibility Complex, Class II, DO Alpha 2 3
  • HLA-DNA 3 4 6
  • MHC Class II Antigen DOA 3 4
  • MHC DN-Alpha 3 4
  • MHC DZ Alpha 3 4
  • HLA-DZA 3 4
  • HLA Class II Histocompatibility Antigen, DO Alpha Chain 3
  • Major Histocompatibility Complex, Class II, DN Alpha 3
  • Lymphocyte Antigen 3
  • HLA-D0-Alpha 3
  • HLADZ 3

External Ids for HLA-DOA Gene

Previous Symbols for HLA-DOA Gene

  • HLA-DZA
  • HLA-DNA

Summaries for HLA-DOA Gene

Entrez Gene Summary for HLA-DOA Gene

  • HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-DOA Gene

HLA-DOA (Major Histocompatibility Complex, Class II, DO Alpha) is a Protein Coding gene. Diseases associated with HLA-DOA include hiv-1. Among its related pathways are Class I MHC mediated antigen processing and presentation and GPCR Pathway. GO annotations related to this gene include MHC class II receptor activity. An important paralog of this gene is HLA-DMA.

UniProtKB/Swiss-Prot for HLA-DOA Gene

  • Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM

Gene Wiki entry for HLA-DOA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-DOA Gene

Genomics for HLA-DOA Gene

Genomic Location for HLA-DOA Gene

Start:
33,004,178 bp from pter
End:
33,009,612 bp from pter
Size:
5,435 bases
Orientation:
Minus strand

Genomic View for HLA-DOA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HLA-DOA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for HLA-DOA Gene

Proteins for HLA-DOA Gene

  • Protein details for HLA-DOA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06340-DOA_HUMAN
    Recommended name:
    HLA class II histocompatibility antigen, DO alpha chain
    Protein Accession:
    P06340
    Secondary Accessions:
    • Q58HU0
    • Q58HU1
    • Q5STC7
    • Q9TQC6
    • Q9TQC7
    • Q9TQC8
    • Q9TQC9
    • Q9TQD0
    • Q9TQD1
    • Q9TQD2
    • Q9TQD3

    Protein attributes for HLA-DOA Gene

    Size:
    250 amino acids
    Molecular mass:
    27599 Da
    Quaternary structure:
    • Heterodimer of an alpha chain (DOA) and a beta chain (DOB). Forms a heterotetrameric complex with an HLA-DM molecule during intracellular transport in endosomal/lysosomal compartments in B-cells

    Three dimensional structures from OCA and Proteopedia for HLA-DOA Gene

neXtProt entry for HLA-DOA Gene

Proteomics data for HLA-DOA Gene at MOPED

Post-translational modifications for HLA-DOA Gene

  • Glycosylation at Asn104 and Asn144

Other Protein References for HLA-DOA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HLA-DOA Gene

Domains for HLA-DOA Gene

Gene Families for HLA-DOA Gene

HGNC:
  • C1SET :Immunoglobulin superfamily / C1-set domain containing
  • HLA :Histocompatibility complex

UniProtKB/Swiss-Prot:

DOA_HUMAN
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.:
    • P06340
Family:
  • Belongs to the MHC class II family.:
    • P06340
genes like me logo Genes that share domains with HLA-DOA: view

Function for HLA-DOA Gene

Molecular function for HLA-DOA Gene

UniProtKB/Swiss-Prot Function: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM

Gene Ontology (GO) - Molecular Function for HLA-DOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0023026 MHC class II protein complex binding IDA 22733780
GO:0032395 MHC class II receptor activity TAS 3000765
genes like me logo Genes that share ontologies with HLA-DOA: view

Phenotypes for HLA-DOA Gene

genes like me logo Genes that share phenotypes with HLA-DOA: view

Animal Models for HLA-DOA Gene

MGI Knock Outs for HLA-DOA:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for HLA-DOA Gene

Localization for HLA-DOA Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLA-DOA Gene

Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HLA-DOA Gene COMPARTMENTS Subcellular localization image for HLA-DOA gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
plasma membrane 4
extracellular 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HLA-DOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane TAS --
GO:0005768 endosome --
GO:0005886 plasma membrane TAS 3000765
GO:0010008 endosome membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with HLA-DOA: view

Pathways for HLA-DOA Gene

genes like me logo Genes that share pathways with HLA-DOA: view

Interacting Proteins for HLA-DOA Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000229829%0d%0a9606.ENSP00000390020%0d%0a9606.ENSP00000363976%0d%0a
Selected Interacting proteins: ENSP00000229829 P06340-DOA_HUMAN for HLA-DOA Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for HLA-DOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002587 negative regulation of antigen processing and presentation of peptide antigen via MHC class II IDA 22733780
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 3000765
GO:0019882 antigen processing and presentation --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with HLA-DOA: view

Transcripts for HLA-DOA Gene

Unigene Clusters for HLA-DOA Gene

Major histocompatibility complex, class II, DO alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-DOA Gene

No ASD Table

Relevant External Links for HLA-DOA Gene

GeneLoc Exon Structure for
HLA-DOA
ECgene alternative splicing isoforms for
HLA-DOA

Expression for HLA-DOA Gene

mRNA expression in normal human tissues for HLA-DOA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HLA-DOA Gene

This gene is overexpressed in Spleen (5.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HLA-DOA Gene

SOURCE GeneReport for Unigene cluster for HLA-DOA Gene Hs.631991

genes like me logo Genes that share expressions with HLA-DOA: view

Orthologs for HLA-DOA Gene

This gene was present in the common ancestor of chordates.

Orthologs for HLA-DOA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HLA-DOA 37
  • 99 (a)
OneToOne
LOC471979 36
  • 98.8 (n)
  • 98.8 (a)
cow
(Bos Taurus)
Mammalia BOLA-DNA 37
  • 72 (a)
OneToOne
BOLA-DOA 36
  • 80.93 (n)
  • 74 (a)
dog
(Canis familiaris)
Mammalia DLA-DOA 36
  • 84.53 (n)
  • 80.4 (a)
DLA-DOA 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia H2-Oa 36
  • 80.13 (n)
  • 73.2 (a)
H2-Oa 16
H2-Oa 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 59 (a)
OneToMany
-- 37
  • 59 (a)
OneToMany
-- 37
  • 56 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RT1-DOa 36
  • 80.27 (n)
  • 71.2 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 48 (a)
ManyToMany
-- 37
  • 46 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:busm1-48c11.3 37
  • 28 (a)
ManyToMany
Species with no ortholog for HLA-DOA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HLA-DOA Gene

ENSEMBL:
Gene Tree for HLA-DOA (if available)
TreeFam:
Gene Tree for HLA-DOA (if available)

Paralogs for HLA-DOA Gene

genes like me logo Genes that share paralogs with HLA-DOA: view

Variants for HLA-DOA Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for HLA-DOA Gene

P06340-DOA_HUMAN
The following alleles of DOA are known: DOA*01:01, DOA*01:02 and DOA*01:03. The sequence shown is that of DOA*01:01

Sequence variations from dbSNP and Humsavar for HLA-DOA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2581 -- 33,006,624(-) ACACA(A/C)ACACA utr-variant-3-prime, downstream-variant-500B
rs2582 -- 33,006,774(-) GACAG(A/C)CCCTG utr-variant-3-prime, missense, reference
rs86567 -- 33,008,982(-) GGCCC(A/C)CCATT intron-variant
rs364950 -- 33,008,119(+) AAGTC(A/G)CCAAA synonymous-codon, reference
rs365066 -- 33,007,480(+) TTGCG(C/T)AGCCA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for HLA-DOA Gene

Variant ID Type Subtype PubMed ID
nsv483081 CNV Loss 15286789

Relevant External Links for HLA-DOA Gene

HapMap Linkage Disequilibrium report
HLA-DOA
Human Gene Mutation Database (HGMD)
HLA-DOA
Locus Specific Mutation Databases (LSDB)
HLA-DOA

Disorders for HLA-DOA Gene

(1) MalaCards Diseases for HLA-DOA Gene

Search for HLA-DOA Gene in MalaCards »

(1) Novoseek inferred disease relationships for HLA-DOA Gene

Disease -log(P) Hits PubMed IDs
hla-do 97.7 1

Relevant External Links for HLA-DOA

Genetic Association Database (GAD)
HLA-DOA
Human Genome Epidemiology (HuGE) Navigator
HLA-DOA
genes like me logo Genes that share disorders with HLA-DOA: view

No data available for UniProtKB/Swiss-Prot for HLA-DOA Gene

Publications for HLA-DOA Gene

  1. The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript. (PMID: 2370084) Young J.A. … Trowsdale J. (Immunogenetics 1990) 2 3 4
  2. Limited polymorphism in the HLA-DOA gene. (PMID: 10323340) Naruse T.K. … Inoko H. (Tissue Antigens 1999) 3 4 23
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Human class II DNA and DOB genes display low sequence variability. (PMID: 2499532) Jonsson A.-K. … Rask L. (Immunogenetics 1989) 3 4

Products for HLA-DOA Gene

  • antibodies-online proteins for HLA-DOA
  • antibodies-online antibodies for HLA-DOA
  • antibodies-online kits for HLA-DOA

Sources for HLA-DOA Gene

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